Adult patients with allied disorders of Hirschsprung’s disease in emergency department: An 11-year retrospective study

Figure 1 Flowchart of selection of allied disorders of Hirschsprung’s disease patients. ADHD: Allied disorders of Hirschsprung’s disease.

Figure 2 Clinical information of adult patients with allied disorders of Hirschsprung’s disease. A: Symptoms duration; B: Treatment received before admission; C: Intestinal dilation parts; D: Clinical manifestations; E: Surgery procedures; F: Postoperative complications.

Figure 3 Classic imaging findings of three patients with allied disorders of Hirschsprung’s disease. A: Computed tomography (CT) revealed significant dilatation of gas in the colon in a 70-year-old man; B: CT dilated colon with a large amount of fecal content in a 51-year-old man; C: CT obvious dilation in the total colon in a 22-year-old girl; D: Enteroscopy revealed dilated sigmoid colon and barium retention in the sigmoid colon and rectum in the 70-year-old man; E: Enteroscopy dilated middle and upper rectum and narrow lower rectum in the 51-year-old man; F: Enteroscopy significant narrowing of the intestine 40 cm from the anus in the 22-year-old girl.

Figure 4 Typical pathological sections of normal intestinal ganglion and resection bowel of allied disorders of patients with Hirschsprung’s disease (hematoxylin-eosin staining). A: Black arrows indicate normal ganglion cells; B: The black arrow indicates the degenerated ganglion cell. The proliferation of nerve fibers and reduction of ganglion cells were also observed. Magnification, × 200.

Figure 5 Receiver operating characteristic curve. Receiver operating characteristic curve analysis showed that body mass index, cholinesterase, and blood chlorine had good discriminative abilities between allied disorders of Hirschsprung’s disease and irritable bowel syndrome. ROC: Receiver operating characteristics; AUROC: Area under the receiver operating characteristics curve; CI: Confidence interval.