Expression of adipokine ghrelin and ghrelin receptor in human colorectal adenoma and correlation with the grade of dysplasia

doi:10.4240/wjgs.v13.i12.1708

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Surg. Dec 27, 2021; 13(12): 1708-1720
Published online Dec 27, 2021. doi: 10.4240/wjgs.v13.i12.1708

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Figure 1 Immunohistochemical expression of ghrelin in adenoma and adjacent tissue. A: Representative image of strong immunohistochemical expression of ghrelin in adenoma with low grade dysplasia (200 × magnification); B: Representative image of strong immunohistochemical expression of ghrelin in adenoma with high grade dysplasia (200 × magnification); C: Representative image of moderate immunohistochemical expression of ghrelin in adjacent tissue (200 × magnification).

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Figure 2 Immunohistochemical expression of ghrelin receptor in adenoma and adjacent tissue. A: Representative image of strong immunohistochemical expression of ghrelin receptor in adenoma with low grade dysplasia (200 × magnification); B: Representative image of strong immunohistochemical expression of ghrelin receptor in adenoma with high grade dysplasia (200 × magnification); C: Representative image of moderate immunohistochemical expression of ghrelin receptor in adjacent tissue (200 × magnification).

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Figure 3 Immunohistochemical expression of ghrelin and ghrelin receptor in adenoma depending on the grade of adenoma dysplasia. A: Immunohistochemical staining index (ISI) of ghrelin in adenoma depending on grade of dysplasia in adenoma; B: ISI of ghrelin receptor in adenoma depending on grade of dysplasia in adenoma. ISI: Immunohistochemical staining index.

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Figure 4 Immunohistochemical expression of ghrelin and ghrelin receptor in adjacent tissue depending on the grade of dysplasia in the corresponding adenoma. A: Immunohistochemical staining index (ISI) of ghrelin in adjacent tissue depending on grade of dysplasia in corresponding adenoma; B: ISI of ghrelin receptor in adjacent tissue depending on grade of dysplasia in corresponding adenoma. ISI: Immunohistochemical staining index.

Citation: Stojsavljevic-Shapeski S, Virovic-Jukic L, Tomas D, Duvnjak M, Tomasic V, Hrabar D, Kralj D, Budimir I, Barsic N, Ljubicic N. Expression of adipokine ghrelin and ghrelin receptor in human colorectal adenoma and correlation with the grade of dysplasia. World J Gastrointest Surg 2021; 13(12): 1708-1720
URL: https://www.wjgnet.com/1948-9366/full/v13/i12/1708.htm
DOI: https://dx.doi.org/10.4240/wjgs.v13.i12.1708