Wei LL, Lai YL, Qiu KH, He X, Yang T. Clinical efficacy of neoadjuvant chemotherapy combined with radical gastrectomy in elderly patients with advanced gastric cancer. World J Gastrointest Surg 2025; 17(9): 106995 [PMID: 41024826 DOI: 10.4240/wjgs.v17.i9.106995]
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03668426
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September 26, 2025, 17:10
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Reader Comments:
Working towards improving transarterial chemoembolization (TACE) outcomes for hepatocellular carcinoma
Eduardo Segovia-Vergara, Arturo Alonso, Rodrigo Mansilla-Vivar
Abstract: Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality worldwide, and transarterial chemoembolization (TACE) is a cornerstone therapy for patients with intermediate or advanced disease. However, TACE outcomes are influenced by multiple clinical, imaging, and psychosocial factors. Recent studies highlight the value of a multidisciplinary approach to optimize post-TACE management. This includes assessing immune, coagulation, and biomarker responses to predict prognosis, applying magnetic resonance imaging bias field correction to improve tumor evaluation, and identifying risk factors for post-procedural complications such as infections. Together, these strategies work towards improving TACE results for HCC, emphasizing the need for integrated care that combines technological, clinical, and supportive interventions.
Dear Editor,
We read with great interest the recent articles addressing transarterial chemoembolization (TACE) for hepatocellular carcinoma (HCC), including the works by Song et al., Liu et al., Fu et al., and Shan et al. These studies provide valuable insights into the clinical, imaging, and systemic aspects of TACE, highlighting its therapeutic potential as well as the challenges in optimizing patient outcomes.
Taken together, these studies emphasize the value of integrating clinical, imaging, and systemic considerations to improve outcome prediction and manage complications in HCC patients undergoing TACE, and they motivate a discussion on strategies aimed at enhancing TACE efficacy through a multidisciplinary approach. Although these studies provide important insights, some are limited by retrospective designs, small sample sizes, among other limitations. Nevertheless, these findings underscore the need for coordinated, multidisciplinary strategies in HCC patients undergoing TACE.
Building on this evidence, this letter aims to discuss potential approaches to enhance TACE outcomes by integrating clinical evaluation, advanced imaging, complication management, and supportive care.