Copyright
©The Author(s) 2018.
World J Diabetes. Sep 15, 2018; 9(9): 157-164
Published online Sep 15, 2018. doi: 10.4239/wjd.v9.i9.157
Published online Sep 15, 2018. doi: 10.4239/wjd.v9.i9.157
Table 1 Anthropometric characteristics of the study population
Healthy controls | Type 2 diabetes cases | |
n | 133 | 177 |
Male/Female | 76/57 | 87/90 |
Age (yr) | 37.49 ± 13.04 | 63.05 ± 11.66 |
BMI (kg/m2) | 25.17 ± 5.35 | 31.73 ± 5.65 |
Table 2 Clinical characteristics of the atypical and classical diabetes cases
Atypical diabetes, n = 92 | Classical diabetes, n = 85 | P | |
Age (yr) | 61.29 ± 13.08 | 65.74 ± 9.93 | 0.011b |
Age ( yr) | 43.36 ± 12.62 | 45.93 ± 14.67 | 0.304 |
BMI (kg/m2) | 32.22 ± 5.48 | 31.32 ± 5.96 | 0.288 |
HbA1c, % | 8.27 ± 1.80 | 8.27 ± 1.77 | 0.993 |
Total cholesterol (mmol/L) | 5.18 ± 1.14 | 5.53 ± 1.16 | 0.044a |
HDL (mmol/L) | 1.24 ± 0.29 | 1.32 ± 0.33 | 0.080 |
LDL (mmol/L) | 2.84 ± 1.02 | 3.26 ± 1.11 | 0.010b |
Triglycerides (mmol/L) | 2.24 ± 1.40 | 2.24 ± 1.4 | 0.991 |
TG/HDL | 4.47 ± 3.41 | 4.43 ± 4.73 | 0.941 |
Table 3 Genotype frequencies of rs12255372 and rs7903146 in controls and cases
SNPs | Healthy controls, % | Type 2 diabetes cases, % | OR (95%CI) | P |
rs12255372 G > T | ||||
G/T + T/T | 48.9 | 60.5 | 1.6 (1.02-2.51) | 0.04 |
G/G | 51.1 | 39.5 | ||
T allele | 30 | 37 | 1.37 (0.97-1.92) | NS |
G allele | 70 | 63 | ||
rs7903146 C > T | ||||
C/T + T/T | 46.6 | 52.5 | 1.27 (0.81-1.99) | NS |
C/C | 53.4 | 47.5 | ||
T allele | 29 | 34 | 1.22 (0.87-1.72) | NS |
C allele | 71 | 66 |
Table 4 Genotype frequencies of rs12255372 and rs7903146 in controls, atypical diabetes and classical diabetes patients
SNPs | Controls, % | Atypical diabetes, % | Classical diabetes, % | OR (95%CI) | P |
rs12255372 G > T | |||||
G/T+T/T | 65 | - | 57 | 2.1 (1.21-3.75) | 0.008 |
G/G | 68 | - | 28 | ||
G/T+T/T | 65 | 50 | - | 1.2 (0.73-2.12) | NS |
G/G | 68 | 42 | - | ||
rs7903146 C > T | |||||
C/T + T/T | 62 | - | 47 | 1.4 (0.82-2.45) | NS |
C/C | 71 | - | 38 | ||
C/T+T/T | 62 | 46 | - | 1.2 (0.67-1.95) | NS |
C/C | 71 | 46 | - |
- Citation: Beloso C, Souto J, Fabregat M, Romanelli G, Javiel G, Mimbacas A. Association of TCF7L2 mutation and atypical diabetes in a Uruguayan population. World J Diabetes 2018; 9(9): 157-164
- URL: https://www.wjgnet.com/1948-9358/full/v9/i9/157.htm
- DOI: https://dx.doi.org/10.4239/wjd.v9.i9.157