Utility of different glycemic control metrics for optimizing management of diabetes

Table 1 Traditional and alternative markers of glycemic control

Marker	Time span ofglycemic control	Ref.
Hemoglobin A1c	1-3 mo	Cohen[15], 2007
Glycated serum proteins	2-3 wk	Takahashi et al[33], 2007
1,5-Anhydroglucitol	1-2 wk	Dungan et al[43], 2008
Glycemic variability indices	24-72 h	Rodbard[54], 2009
Mean plasma glucose	24-72 h	Bergenstal et al[30], 2013
Fasting plasma glucose	8-10 h	Monami et al[22], 2013
Postprandial plasma glucose	2-4 h	Standl et al[23], 2011

Table 2 Linear regression relating hypoglycemia as dependent variable with measures of glycemic control as independent variables in type 2 diabetes

Asymptomatic hypoglycemia	Measure	R²	P value
Time (h/d) spent	GRADEHYPO	0.734	< 0.001
< 3.9 mmol/L	LBGI	0.471	< 0.001
	% CV	0.293	< 0.001
	HbA1c	0.048	0.02

Data analyzed from 114 patients treated with diet and oral antidiabetic drugs. GRADE_HYPO: Glycemic risk assessment diabetes equation hypoglycemia; LBGI: Low blood glucose index; %CV: Percent coefficient of variation (Kohnert et al, Unpublished data).