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©2013 Baishideng Publishing Group Co.
World J Diabetes. Oct 15, 2013; 4(5): 219-225
Published online Oct 15, 2013. doi: 10.4239/wjd.v4.i5.219
Published online Oct 15, 2013. doi: 10.4239/wjd.v4.i5.219
n | Men (n = 561) | Women (n = 663) | |||||||||||||
1 4.941 | 2 8.50 | 3 15.36 | AnovaP-trend | 1 6.121 | 2 10.87 | 3 19.67 | AnovaP-trend | ||||||||
Mean | SD | Mean | SD | Mean | SD | Mean | SD | Mean | SD | Mean | SD | ||||
Age (yr) | 1224 | 52.2 | 10.1 | 53.8 | 11 | 58.14 | 11.9 | < 0.001 | 52.8 | 10.3 | 53.5 | 11.9 | 57.14 | 12 | < 0.001 |
BMI (kg/m2) | 1213 | 28.2 | 4 | 29.3 | 4.3 | 27.3 | 4.5 | 0.23 | 31.84 | 6 | 30.3 | 4.8 | 30.1 | 5.7 | 0.003 |
Waist circumfer. (cm) | 1217 | 97.3 | 11.1 | 96.8 | 10.6 | 95 | 11.9 | 0.11 | 94.3 | 12.7 | 92.1 | 11.4 | 91.2 | 12.7 | 0.024 |
Systolic BP (mmHg) | 1217 | 120.6 | 18.8 | 121.3 | 19.6 | 121.8 | 20.3 | 0.83 | 130.5 | 23.9 | 126.4 | 21.7 | 127.3 | 23.7 | 0.15 |
Diastolic BP (mmHg) | 1217 | 77.8 | 10.8 | 77.7 | 10.3 | 77.6 | 10.6 | 0.98 | 80.8 | 11.5 | 79.7 | 10.4 | 80 | 11.8 | 0.54 |
Complement C3 (g/L) | 610 | 1.36 | 0.27 | 1.29 | 0.27 | 1.23 | 0.27 | 0.007 | 1.44 | 0.29 | 1.37 | 0.33 | 1.24 | 0.24 | < 0.001 |
CRP3 (mg/L) | 1143 | 2.26 | 1.25-5.06 | 2.11 | 1.02-3.9 | 1.424 | 0.76-3.2 | < 0.001 | 2.72 | 1.15-6.33 | 2.61 | 1.21-6.18 | 2.29 | 1.08-4.0 | 0.025 |
Total cholest. (mg/dL) | 1213 | 191.3 | 40 | 194.8 | 38 | 190 | 40.3 | 0.46 | 201 | 41.7 | 205.4 | 53 | 204.9 | 44.3 | 0.54 |
Fast. glucose, (mg/dL) | 1124 | 99 | 39 | 99.6 | 37.8 | 94 | 25.8 | 0.27 | 101.9 | 43.9 | 99 | 38.2 | 93.7 | 32 | 0.093 |
ApoB (mg/dL) | 1116 | 107.6 | 26.7 | 105.3 | 28.9 | 100.4 | 46.9 | 0.15 | 106 | 26.3 | 104.3 | 32.5 | 106.9 | 37.5 | 0.72 |
Creatinine (mg/dL) | 1144 | 1.02 | 0.19 | 1.02 | 0.22 | 0.99 | 0.22 | 0.24 | 0.78 | 0.21 | 0.79 | 0.18 | 0.84 | 0.42 | 0.066 |
Fast. triglycer.3 (mg/dL) | 1123 | 160.84 | 108-227 | 138.1 | 100-187 | 126.2 | 89-174 | < 0.001 | 146.2 | 108-206 | 133.5 | 99.9-182 | 1174 | 83.5-164 | < 0.001 |
HDL-cholest. (mg/dL) | 1207 | 35.6 | 8.3 | 39.5 | 9.8 | 434 | 11.3 | < 0.001 | 43.9 | 11.5 | 45.6 | 10.6 | 49.44 | 11.7 | < 0.001 |
Apo A-I (mg/dL) | 1103 | 129.7 | 25 | 134.7 | 25.1 | 138.9 | 25.8 | 0.004 | 144.3 | 26.4 | 145.7 | 29.9 | 152.6 | 28.1 | 0.008 |
Lp (a)3 (mg/dL) | 764 | 8.16 | 3.8-18.2 | 7.93 | 3.2-19.4 | 9.36 | 3.4-20.6 | 0.52 | 12.1 | 5.3-24.5 | 13.3 | 5.7-23.6 | 12.4 | 4-29.4 | 0.85 |
Thyroid SH3 (mIU/L) | 532 | 1.06 | 0.7-1.6 | 1.05 | 0.6-1.7 | 1.01 | 0.67-1.5 | 0.89 | 1.53 | 0.97-2.45 | 1.47 | 0.84-2.3 | 1.37 | 1.0-2.46 | 0.70 |
Current/former smok (%) | 1218 | 58.4 | 20 | 47.9 | 21.1 | 45.9 | 29 | 0.035 | 16 | 3.7 | 18.6 | 3.6 | 14.7 | 3.7 | 0.87 |
Prevalent diabetes2 (%) | 1219 | 11.8 | 12.6 | 13.1 | 0.93 | 17.7 | 12.1 | 12.9 | 0.18 | ||||||
Incident CHD, n (%) | 1061 | 13 (8.2) | 11 (6.7) | 4 (2.5) | 0.086 | 21 (11.1) | 8; 4 | 16 (8.4) | 0.029 |
Total | Men | Women | Total | Men | Women | ||||||||
βcoeff. | P value | βcoeff | P value | βcoeff | P value | βcoeff | P value | βcoeff | P value | βcoeff | P value | ||
Model 1 | n = 513 | n = 252 | n = 261 | Model 2 | n = 454 | n = 223 | n = 231 | ||||||
Sex (female) | 1.20 | < 0.001 | Sex (female) | 1.285 | < 0.001 | ||||||||
Age (11 yr) | 1.05 | 0.055 | 1.10 | 0.005 | 0.997 | 0.93 | Age (11 yr) | 1.04 | 0.13 | 1.067 | 0.079 | 1.007 | 0.88 |
Fasting insulin1 | 0.79 | 0.009 | 0.80 | 0.016 | 0.79 | 0.033 | C-reactive protein1 | 0.90 | 0.057 | 0.83 | 0.011 | 0.98 | 0.80 |
SHBG1 (nmol/L) | 2.14 | < 0.001 | 1.76 | 0.001 | 2.02 | < 0.001 | SHBG1 | 1.97 | < 0.001 | 1.77 | 0.002 | 2.08 | < 0.001 |
Creatinine (0.25 mg/dL) | 1.04 | 0.67 | 0.992 | 0.82 | 1.085 | 0.052 | Fasting insulin1 | 0.84 | 0.026 | 0.83 | 0.06 | 0.86 | 0.20 |
Creatinine (0.25 mg/dL) | 1.04 | 0.14 | 1.01 | 0.78 | 1.081 | 0.086 | |||||||
Waist circumference (12 cm) | 1.023 | 0.41 | 1.021 | 0.57 | 1.025 | 0.52 | |||||||
Lipoprotein(a)1 | 1.003 | 0.94 | 1.07 | 0.38 | 0.96 | 0.60 |
Total HR | 95%CI | Men HR | 95%CI | Women HR | 95%CI | |
Diabetes | 40/7612 | 21/3332 | 19/4282 | |||
Adiponectin mid-tertile | 0.64 | 0.32-1.31 | 0.83 | 0.30-2.28 | 0.35 | 0.11-1.09 |
Adiponectin top-tertile | 0.26 | 0.10-0.69 | 0.28 | 0.07-1.17 | 0.23 | 0.06-0.88 |
Fasting glucose (25 mg/dL) | 1.60 | 1.22-2.04 | 1.49 | 1.08-2.09 | 2.25 | 1.35-3.72 |
Waist circumference (12 cm) | 1.88 | 1.43-2.46 | 2.04 | 1.44-2.88 | 1.78 | 1.13-2.78 |
Creatinine (0.25 mg/dL) | 1.08 | 0.74-1.58 | 0.77 | 0.37-1.60 | 1.18 | 0.87-1.60 |
C-reactive protein1, 3-fold | 1.21 | 0.97-1.52 | 1.10 | 0.80-1.51 | 1.36 | 0.96-1.73 |
Coronary disease | 66/8052 | 25/3582 | 41/4472 | |||
Adiponectin mid-tertile | 0.54 | 0.30-0.97 | 0.8 | 0.34-1.92 | 0.39 | 0.17-0.90 |
Adiponectin top-tertile | 0.49 | 0.26-0.91 | 0.31 | 0.09-1.05 | 0.66 | 0.32-1.38 |
Non-HDL cholester. (35 mg/dL) | 1.07 | 0.87-1.28 | 1.37 | 0.97-1.93 | 0.93 | 0.70-1.19 |
Waist circumference (12 cm) | 1.46 | 1.18-1.82 | 1.28 | 0.89-1.84 | 1.60 | 1.22-2.08 |
Creatinine (0.25 mg/dL) | 1.20 | 0.91-1.58 | 1.36 | 0.85-2.17 | 1.05 | 0.69-1.60 |
C-reactive protein1, (3-fold) | 1.12 | 0.95-1.32 | 1.06 | 0.81-1.39 | 1.18 | 0.95-1.47 |
Hypertension | 120/5412 | 53/2742 | 67/2672 | |||
Adiponectin mid-tertile | 1.08 | 0.71-1.91 | 1.23 | 0.62-2.43 | 1.03 | 0.56-1.89 |
Adiponectin top-tertile | 0.77 | 0.55-1.59 | 1.08 | 0.51-2.30 | 0.64 | 0.33-1.24 |
Waist circumference (12 cm) | 1.41 | 1.14-1.74 | 1.28 | 0.93-1.76 | 1.53 | 1.14-2.06 |
Creatinine (0.25 mg/dL) | 1.06 | 0.82-1.37 | 1.15 | 0.80-1.66 | 1.08 | 0.74-1.59 |
C-reactive. protein1, 3-fold | 0.96 | 0.85-1.09 | 1.08 | 0.90-1.30 | 0.90 | 0.76-1.06 |
- Citation: Onat A, Aydın M, Can G, Köroğlu B, Karagöz A, Altay S. High adiponectin levels fail to protect against the risk of hypertension and, in women, against coronary disease: involvement in autoimmunity? World J Diabetes 2013; 4(5): 219-225
- URL: https://www.wjgnet.com/1948-9358/full/v4/i5/219.htm
- DOI: https://dx.doi.org/10.4239/wjd.v4.i5.219