Genetics of type 2 diabetes

Table 1 Thirty-eight genetic variants associated with type 2 diabetes at genome-wide significance

Locus	Chr	Risk allele frequency	OR (95%CI)
NOTCH2	1	0.11	1.13 (1.08-1.17)
PROX1	1	0.5	1.07 (1.05-1.09)
IRS1	2	0.61	1.19 (1.13-1.25)
THADA	2	0.92	1.15 (1.10-1.20)
RBMS1/ITGB6	2	0.57	1.11 (1.08-1.16)
BCL11A	2	0.46	1.08 (1.06-1.10)
GCKR	2	0.62	1.06 (1.04-1.08)
IGF2BP2	3	0.29	1.17 (1.10-1.25)
PPARG	3	0.92	1.14 (1.08-1.20)
ADCY5	3	0.78	1.12 (1.09-1.15)
ADAMTS9	3	0.81	1.09 (1.06-1.12)
WFS1	4	0.27	1.13 (1.07-1.18)
ZBED3	5	0.26	1.08 (1.06-1.11)
CDKAL1	6	0.31	1.12 (1.08-1.16)
JAZF1	7	0.52	1.10 (1.07-1.13)
GCK	7	0.2	1.07 (1.05-1.10)
KLF14	7	0.55	1.07 (1.05-1.10)
DGKB/TMEM195	7	0.47	1.06 (1.04-1.08)
SLC30A8	8	0.75	1.12 (1.07-1.16)
TP53INP1	8	0.48	1.06 (1.04-1.09)
CDKN2A/B	9	0.79	1.20 (1.14-1.25)
TLE4	9	0.93	1.11 (1.07-1.15)
TCF7L2	10	0.25	1.37 (1.28-1.47)
HHEX	10	0.56	1.13 (1.08-1.17)
CDC123/CAMK1D	10	0.23	1.11 (1.07-1.14)
KCNQ1	11	0.61	1.40 (1.34-1.47)
KCNJ11/ABCC8	11	0.5	1.15 (1.09-1.21)
CENTD2	11	0.88	1.14 (1.11-1.17)
MTNR1B	11	0.3	1.09 (1.06-1.12)
KCNQ1	11	0.52	1.08 (1.06-1.10)
HMGA2	12	0.1	1.10 (1.07-1.14)
TSPAN8/LGR5	12	0.23	1.09 (1.06-1.12)
OASL/HNF1A	12	0.85	1.07 (1.05-1.10)
PRC1	15	0.22	1.07 (1.05-1.09)
ZFAND6	15	0.56	1.06 (1.04-1.08)
FTO	16	0.45	1.15 (1.09-1.22)
HNF1B	17	0.43	1.12 (1.07-1.18)
DUSP9	X	0.12	1.27 (1.18-1.37)

Modified from Florez et al[71].