Increased tumor necrosis factor-receptor superfamily plasma levels are associated with early renal or retinal involvement in intermediate hyperglycemia

Table 1 Summary of the statistical significance of the variables associated with hyperfiltration, with corresponding P values and false discovery rate-adjusted values

Variables	P value	FDR
IL-6 (pg/mL)	8.81 × 10-18	6.35 × 10-16
TIM-3 (pg/mL)	2.10 × 10-5	0.00066
TNF-R2 (pg/mL)	2.37 × 10-5	0.0006
Gal3 (pg/mL)	0.0001	0.0029
TNF-R1 (pg/mL)	0.0002	0.0035
ALT (UI/L)	0.0130
Disposition index	0.0253
Triglycerides (mmol/L)	0.0484

FDR: False discovery rate; IL-6: Interleukin-6; TIM-3: T-cell immunoglobulin and mucin domain 3; TNF-R2: Tumor necrosis factor receptor 2; Gal3: Galectin-3; TNF-R1: Tumor necrosis factor receptor 1; ALT: Alanine aminotransferase. Bonferroni threshold for our study is P > 0.0007.

Table 2 Summary of the statistical significance of the variables associated with the presence of albuminuria, with the corresponding P values and false discovery rate-adjusted values

Variables	P value	FDR
TIM3 (pg/mL)	4.10 × 10-5	0.0016
TNF-R2 (pg/mL)	7.75 × 10-5	0.0019
IL-6 (pg/mL)	0.0001	0.0019
Gal3 (pg/mL)	0.0006	0.0081
TNF-R1 (pg/mL)	0.0007	0.0081
Disposition index	0.0118
QUICKI	0.0355
Matsuda index	0.0429

FDR: False discovery rate; IL-6: Interleukin-6; TIM-3: T-cell immunoglobulin and mucin domain 3; TNF-R2: Tumor necrosis factor receptor 2; Gal3: Galectin-3; TNF-R1: Tumor necrosis factor receptor 1; QUICKI: Quantitative insulin sensitivity check index. Bonferroni threshold for our study is P > 0.0007.

Table 3 Summary of the statistical significance of the variables associated with hypofiltration, showing the P values and false discovery rate-adjusted values

Variables	P value	FDR
TNF-R1	6.65 × 10-6	0.00044
TNF-R2	0.00015	0.0046
TIM-3	0.0006	0.012
Gal3	0.01
Age	0.02
IL-6	0.04
LDL	0.045

FDR: False discovery rate; IL-6: Interleukin-6; TIM-3: T-cell immunoglobulin and mucin domain 3; TNF-R2: Tumor necrosis factor receptor 2; Gal3: Galectin-3; TNF-R1: Tumor necrosis factor receptor 1; LDL: Low-density lipoprotein. Bonferroni threshold for our study is P > 0.0007.

Table 4 The statistical significance of the variables associated with presence of retinopathy

Variables	P value	FDR adjusted
TIM-3 (pg/mL)	7.10 × 10-6	0.0001023
Gal3 (pg/mL)	1.02 × 10-5	0.0001229
TNF-R1 (pg/mL)	0.00012715	0.0013078
TNF-R2 (pg/mL)	0.00093481	0.0084133
Glucose > 155mg/dL at 1 hour	0.057532
C-reactive protein	0.058425

FDR: False discovery rate; TIM-3: T-cell immunoglobulin and mucin domain 3; TNF-R2: Tumor necrosis factor receptor 2; Gal3: Galectin-3; TNF-R1: Tumor necrosis factor receptor 1.