L-arginine administration exacerbates myocardial injury in diabetics via prooxidant and proinflammatory mechanisms along with myocardial structural disruption

Table 1 The effect of oral administration of L-arginine on rats’ blood glucose concentrations at 0, 30, 60, 90, and 120 minutes, mean ± SD

Experimental groups	0 minutes	30 minutes	60 minutes	90 minutes	120 minutes
Control	80.4 ± 5.4	91.8 ± 3.3	125 ± 5.2	120.2 ± 4.4	88 ± 4.2
L-Arg (0.5 gm/kg)	85.7 ± 6.6	98.8 ± 4.5	133.3 ± 8.2	134 ± 4.5	97.2 ± 5.4
L-Arg (1 gm/kg)	94.2 ± 7	105.6 ± 4.2	148.8 ± 8.7	152.4 ± 6.7	109.8 ± 7.2
L-Arg (1.5 gm/kg)	101.2 ± 7.2	117.3 ± 6.2	160 ± 7.7	162.5 ± 6.4	115.3 ± 6.1
Diabetic	155.2 ± 10.6	215.3 ± 11.3	278.5 ± 10.6	262.8 ± 12.3	198.2 ± 11.3
D + L-Arg (0.5 gm/kg)	168.9 ± 8.4	221.2 ± 10.6	289.3 ± 10.9	272.2 ± 9.8	215.3 ± 10.6
D + L-Arg (1 gm/kg)	174.2 ± 9.5	270.1 ± 9.9	315.4 ± 11.3	330.5 ± 13.3	275.6 ± 12.5
D + L-Arg (1.5 gm/kg)	180.5 ± 9.7	300.1 ± 13.2	366.8 ± 14.1	379.3 ± 14.2	291.1 ± 11.6

L-Arg: L-arginine.