Meng M, Shi LL. Serum tumor markers expression (CA199, CA242, and CEA) and its clinical implications in type 2 diabetes mellitus. World J Diabetes 2024; 15(2): 232-239 [PMID: 38464372 DOI: 10.4239/wjd.v15.i2.232]
Corresponding Author of This Article
Li-Li Shi, MD, PhD, Chief Doctor, Department of Cadre Ward, The First Affiliated Hospital of Harbin Medical University, No. 23 Postal Street, Nangang District, Harbin 150001, Heilongjiang Province, China. shi_lili1983@163.com
Research Domain of This Article
Research & Experimental Medicine
Article-Type of This Article
Observational Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Diabetes. Feb 15, 2024; 15(2): 232-239 Published online Feb 15, 2024. doi: 10.4239/wjd.v15.i2.232
Table 1 General characteristics was compared between two groups
Variables
Control group (n = 51)
T2DM group (n = 82)
χ2/Z/t value
P value
Gender (male/female)
27/24
47/35
0.244
0.621
Age (yr)
57.98 ± 11.72
59.02 ± 11.58
0.503
0.616
ALT (U/L)
18.40 (13.20, 28.30)
18.75 (13.48, 30.93)
0.558
0.577
AST (U/L)
18.80 (11.80, 30.10)
16.25 (12.48, 24.80)
0.694
0.488
SUA (mmol/L)
312.51 ± 119.36
306.20 ± 102.97
0.323
0.747
Cre (mmol/L)
68.36 ± 27.54
70.16 ± 28.67
0.357
0.721
HbA1c (%)
5.30 (4.30, 6.60)
9.30 (8.18, 11.13)
9.013
0
FBG (mmol/L)
4.46 ± 0.89
10.08 ± 4.30
9.199
0
BMI (kg/m2)
25.15 ± 4.28BMI
25.55 ± 3.40
0.602
0.548
LDL-C (mmol/L)
2.30 (1.90, 3.30)
2.34 (1.94, 3.23)
0.201
0.84
TG (mmol/L)
1.40 (1.10, 2.30)
1.81 (1.09, 2.68)
1.581
0.144
TC (mmol/L)
4.45 ± 1.39
4.46 ± 1.29
0.049
0.961
Table 2 Comparison of carcinoembryonic antigen, cancer antigen 199, cancer antigen 242 between two groups
Variables
Control group (n = 51)
T2DM group (n = 82)
Z value
P value
CEA
2.10 (1.40, 2.70)
2.70 (1.90, 3.65)
3.279
0.000
CA199
7.60 (4.40, 10.10)
11.30 (5.57, 22.13)
3.976
0.000
CA242
6.10 (3.10, 6.90)
6.25 (4.13, 9.20)
0.891
0.373
Table 3 Multivariate logistic regression analysis of factors associated with the onset of type 2 diabetes mellitus
Factors
β value
SE
Wald
P value
OR
95%CI
FBG
1.155
0.378
9.330
0.002
3.173
1.513-6.658
HBA1C
1.517
0.443
11.739
0.001
4.560
1.914-10.863
CEA
0.312
0.147
4.505
0.034
1.366
1.024-1.822
CA199
0.034
0.011
9.554
0.002
1.035
1.013-1.057
CA242
0.145
0.115
1.585
0.208
1.156
0.923-1.448
Table 4 Comparison of general clinical characteristics and tumor marks of different glycosylated hemoglobin % diabetes patients
Variables
Group A (HbA1c ≤ 9%) (n = 37)
Group B (HbA1c > 9%) (n = 45)
t/Z value
P value
Age (yr)
60.08 ± 9.58
58.16 ± 13.05
0.747
0.457
Gender (male/female)
21/16
26/19
0.009
0.926
Course of disease (yr)
6 (3.00, 10.50)
9 (4, 15.00)
1.627
0.104
BMI (kg/m2)
26.09 ± 2.66
25.11 ± 3.88
1.349
0.181
FBG (mmol/L)
8.41 ± 2.79
11.46 ± 4.84
3.386
0.001
LDL-C (mmol/L)
2.33 (1.93, 3.02)
2.38 (1.94, 3.32)
0.680
0.496
TG (mmol/L)
2.00 (1.23, 3.01)
1.57 (0.96, 2.61)
1.142
0.254
TC (mmol/L)
4.54 ± 1.02
4.40 ± 1.48
0.494
0.623
Cre (umol/L)
71.07 ± 19.33
69.40 ± 34.72
0.261
0.795
SUA (umol/L)
333.64 ± 99.56
283.64 ± 101.27
2.242
0.028
ALT (U/L)
17.30 (12.65, 28.75)
19.90 (14.05, 31.45)
0.778
0.437
CEA (ng/mL)
1.90 (1.20, 2.60)
3.40 (2.60, 5.25)
5.488
0.000
CA199 (U/mL)
7.60 (4.15, 10.60)
21.00 (11.85, 26.85)
4.795
0.000
CA242 (U/mL)
5.90 (3.85, 7.15)
6.50 (4.80, 9.30)
1.622
0.105
Table 5 Correlation analysis of carcinoembryonic antigen, cancer antigen 199, cancer antigen 242 levels with glycosylated hemoglobin, fasting blood sugar and lipid metabolism in diabetes patients
Variables
CEA
CA199
CA242
r value
P value
r value
P value
r value
P value
HbA1c
0.308
0.000
0.426
0.000
0.551
0.000
FBG
0.236
0.033
0.231
0.037
0.298
0.006
LDL-C
0.138
0.216
0.238
0.032
0.240
0.030
TG
0.136
0. 222
0.105
0.346
0.051
0.649
TC
0.077
0.494
0.171
0.125
0.149
0.183
Citation: Meng M, Shi LL. Serum tumor markers expression (CA199, CA242, and CEA) and its clinical implications in type 2 diabetes mellitus. World J Diabetes 2024; 15(2): 232-239