Myricetin induces M2 macrophage polarization to alleviate renal tubulointerstitial fibrosis in diabetic nephropathy via PI3K/Akt pathway

doi:10.4239/wjd.v15.i1.105

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Jan 15, 2024 (publication date) through Feb 21, 2025

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World Journal of Diabetes

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World J Diabetes. Jan 15, 2024; 15(1): 105-125
Published online Jan 15, 2024. doi: 10.4239/wjd.v15.i1.105

Table 1 Primers used in real-time PCR, 5-3

Gene	Forward primer	Reverse primer
Kim-1	ACATATCGTGGAATCACAACGAC	ACAAGCAGAAGATGGGCATTG
Ngal	TGGCCCTGAGTGTCATGTG	CTCTTGTAGCTCATAGATGGTGC
Col1a1	GCTCCTCTTAGGGGCCACT	CCACGTCTCACCATTGGGG
α-Sma	GTCCCAGACATCAGGGAGTAA	TCGGATACTTCAGCGTCAGGA
iNos	GTTCTCAGCCCAACAATACAAGA	GTGGACGGGTCGATGTCAC
Tnf-a	CCCTCACACTCAGATCATCTTCT	GCTACGACGTGGGCTACAG
Il-6	TAGTCCTTCCTACCCCAATTTCC	TTGGTCCTTAGCCACTCCTTC
Il-1β	GCAACTGTTCCTGAACTCAACT	ATCTTTTGGGGTCCGTCAACT
Il-10	GCTCTTACTGACTGGCATGAG	CGCAGCTCTAGGAGCATGTG
Arg-1	CTCCAAGCCAAAGTCCTTAGAG	AGGAGCTGTCATTAGGGACATC

α-Sma: Alpha-smooth muscle actin; Arg-1: Arginase-1; Col1a1: Collagen-1a1; Il: Interleukin; iNos: Inducible nitric oxide synthase; Kim-1: Kidney injury molecule-1; Ngal: Neutrophil gelatinase associated lipocalin; Tnf-a: Tumor necrosis factor-alpha.

Citation: Xu WL, Zhou PP, Yu X, Tian T, Bao JJ, Ni CR, Zha M, Wu X, Yu JY. Myricetin induces M2 macrophage polarization to alleviate renal tubulointerstitial fibrosis in diabetic nephropathy via PI3K/Akt pathway. World J Diabetes 2024; 15(1): 105-125
URL: https://www.wjgnet.com/1948-9358/full/v15/i1/105.htm
DOI: https://dx.doi.org/10.4239/wjd.v15.i1.105