Review
Copyright ©The Author(s) 2022.
World J Diabetes. Dec 15, 2022; 13(12): 1001-1013
Published online Dec 15, 2022. doi: 10.4239/wjd.v13.i12.1001
Table 1 Micro-RNAs in diabetic foot and wound healing
Name
Expression
Animal
Target gene
Pathway
Phase
Ref.
miRNA-217UpMouseHIF-1αVEGFInflammationLin et al[32], 2019
miRNA-23cUp/SDF-1αSDF-1α/CXCL12InflammationAmin et al[33], 2020
miRNA-497DownMouseIL-1β, IL-6, TNF-αNF-κBInflammationBan et al[34], 2020
miRNA-155UpMouseFGF7/Inflammation/regenerationMoura et al[36], 2019; Gondaliya et al[51], 2022
miRNA-18a/19aUp/TSP-1/ProliferationWang et al[40], 2020
miRNA-15a-3pUpMouseNOX5ROSProliferationXiong et al[41], 2020
miRNA-152-3pUpMousePTEN/ProliferationXu et al[45], 2020
miRNA-133bUpMouseEGFR/ProliferationZhong et al[46], 2021
miRNA-195-5pUpRatVEGFA/ProliferationLiu et al[42], 2021
miRNA-205-5pUpRatVEGFA/ProliferationLiu et al[42], 2021
miRNA-199a-5pUpRatVEGFA, ROCK1/ProliferationWang et al[49], 2022
miRNA-203UpRatIL-8AKTRegenerationYuan et al[52], 2019
/p63/RegenerationLiu et al[53], 2022
miR-489-3pUpRatSIRT1PI3K/AKT/eNOSRegenerationHuang et al[47], 2022
miRNA-21-3pDownMouseSPRY1FGFRegenerationWu et al[56], 2020
miRNA-146aDown/AKAP12Wnt/β-cateninRegenerationPeng et al[57], 2022
/TLR4NF-κBInflammationZhang et al[58], 2022
Table 2 Long non-coding RNAs in diabetic foot and wound healing
Name
Expression
Sponge
Animal
Target gene
Pathway
Phase
Ref.
GAS5Up/MouseSTAT1/InflammationHu et al[64], 2020
/MouseTAF15HIF-1α/VEGFProliferationPeng et al[65], 2021
MALAT1Down//HIF-1α/Nrf2ProliferationJayasuriya et al[69], 2020
Lnc01435Up/MouseYY1, HDACsNotchProliferationFu et al[70], 2022
H19UpmiRNA-29bMouseFBN1TGF-β/SmadRegenerationLi et al[72], 2021
Up/RatCTGF, SRFMAPKRegenerationLi et al[74], 2020
URIDSUp/RatPlod1VEGF/TGF-βRegenerationHu et al[27], 2020
CASC2DownmiR-155MouseHIF-1α/RegenerationHe et al[76], 2022
Table 3 Circular RNAs in diabetic foot and wound healing
Name
Expression
Sponge
Animal
Target gene
Phase
Ref.
Circ_PRKDCUp//EGFRProliferationWang et al[84], 2020
UpmiR-31/FBN1ProliferationHan et al[83], 2021
Circ_Klhl8DownmiR-212-3pMouseSIRT5ProliferationShang et al[85], 2021
Table 4 Non-coding RNAs in cell therapy
Name
Origin
Expression
Sponge
Target gene
Phase
Ref.
miRNA-155MSCUp/FGF7ProliferationMoura et al[36], 2019; Gondaliya et al[51], 2022
miR-129MSCDown/TRAF6ProliferationHu et al[92], 2022
miRNA-221-3pEPCDown/HIPK2ProliferationYu et al[94], 2022
LncRNA H19MSCUpmiRNA-152-3PPTENProliferationLi et al[95], 2020
MALAT1MSCDownmiR-205-5pVEGFProliferationZhu et al[97], 2019
Lnc KLF3-AS1BMSCDownmiR-383VEGFAProliferationHan et al[99], 2022
Circ_0000250ADSCDownmiR-128-3pSIRT1ProliferationShi et al[100], 2020
Circ_ARHGAP12MSCDownmiR-301b-3pATG16L1, ULK2ProliferationMeng et al[101], 2022
Circ HIPK3MSCDownmiR-20b-3pNrf2/VEGFAProliferationLiang et al[102], 2022