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Jul 15, 2021 (publication date) through Oct 26, 2025
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World Journal of Diabetes
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1948-9358
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright ©The Author(s) 2021.
World J Diabetes. Jul 15, 2021; 12(7): 1081-1092
Published online Jul 15, 2021. doi: 10.4239/wjd.v12.i7.1081
Table 1 Names, loci, and molecular masses of granin proteins[1,2]
Name
Synonym
Locus
Number of amino acids and calculated molecular mass (kDa)
Chromogranin AParathyroid secretory protein 114q32.12439 (49 kDa)
Chromogranin BSecretogranin I20pter-p12657 (77 kDa)
Secretogranin IIChromogranin C2q35-q36587 (68 kDa)
Secretogranin III–15q21449 (51 kDa)
HISL-191Secretogranin IV––
7B2Secretogranin V15q13-q14186 (21 kDa)
NESP55Secretogranin VI20q13.2201 (23 kDa)
VGFSecretogranin VII7q22.1593 (65 kDa)
proSAASSecretogranin VIIIXp11.23227 (24 kDa)
1HISL-19 has only been confirmed with monoclonal antibodies; in vivo isolation has not been successful to date[2,87]. NESP55: Neuroendocrine secretory protein with an apparent molecular weight of 55,000 Daltons.
Full Size Table
Table 2 Cleavage products of granin proteins[1,3,88-90]
Granin protein
Cleavage product
CgA1Vasostatin-I (CgA1-76) and -II (CgA1-115)
Betagranin (CgA1-128)
CgA10-19 and CgA43-521
Chromofungin (CgA47-66)
Vasoconstriction-inhibiting factor (CgA79-113)
Chromostatin (CgA124-143)
Chromacin (CgA173-194)
Pancreastatin (CgA250-301)1
WE-14 (CgA324-337)1
Cateslitin (CgA344-358)
Catestatin (CgA352-372)1
Parastatin (CgA357-428)
GE-25 (CgA367-391)
Serpinin (CgA417-442)
CgB1CgB1-41
GAWK (CgB420-493)
BAM-1745 (CgB579-593)
PE-11 (CgB555-565)
Secretolytin (CgB647-657)
43kDa large CgB fragment
SgII1Secretoneurin (conjugate of SgII133-151 and SgII154-186)
EM66 (66 amino acid long)
Manserin (SgII497-536)
SgIII1–2
HISL-19–2
7B2–2
NESP55LSAL (NESP55159-162)
GAIPIRRH (NESP55234-241)
VGFNeuroendocrine regulatory peptide-1 (VGF281-306)
Neuroendocrine regulatory peptide-2 (VGF310-347)
NAPP129 or VGF20 (VGF417-617)
TPGH (VGF422-430)
TLQP-21 (VGF556-576)
TLQP-62 or VGF10 (VGF556-617)
HHPD-41 (VGF576-617)
AQEE-11 (VGF588-599)
AQEE-30 (VGF588-617)
LQEQ-19 (VGF599-617)
proSAASKEP (proSAAS1-7)
Big SAAS (proSAAS1-26)
Little SAAS (proSAAS9-26)
GAV
PEN (proSAAS188-209)
PEN-LEN (proSAAS188-227)
Little LEN (proSAAS212-221)
Big LEN (proSAAS212-227)
1Granins and their cleavage products involved in carbohydrate metabolism.
2No cleavage product described to date. CgA: Chromogranin A; CgB: Chromogranin B; NESP55: Neuroendocrine secretory protein with an apparent molecular weight of 55000 Daltons; SgII: Secretogranin II.
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