Comparison of clinical features and outcomes in peritoneal dialysis-associated peritonitis patients with and without diabetes: A multicenter retrospective cohort study

Table 1 Clinical manifestations and laboratory parameters of 1065 peritoneal dialysis-associated peritonitis events

Index	DM (n = 373)	Non-DM (n = 692)	P
Clinical manifestation
Fever	115 (30.8)	253 (36.6)	0.061
Abdominal pain	300 (80.4)	552 (79.8)	0.797
PD cell count on admission(/μL)	1920 (620, 5350)	1847 (613, 4974)	0.791
Laboratory test
WBC (1012/L)	8.27 (6.57, 10.98)	8.29 (6.09, 11.43)	0.903
Hb (g/L)	97 (84, 109)	99 (85, 113)	0.128
Alb (g/dL)	28.24 ± 6.24	29.42 ± 6.29	0.003
BUN (mmol/L)	14.85 (10.79, 20.16)	15.68 (12.01, 19.92)	0.090
Scr (μmol/L)	672.66 (511.00, 854.50)	735.60 (511.00, 954.35)	0
eGFR	6.29 (4.68, 8.38)	5.70 (4.35, 7.28)	0

DM: Diabetes mellitus; PD: Peritoneal dialysis; WBC: White cell count; Hb: Hemoglobin; Alb: Albumin; BUN: Blood urea nitrogen; Scr: Serum creatinine; eGFR: Estimated glomerular filtration rate.

Table 2 Causative organisms of 1065 peritoneal dialysis-associated peritonitis

Organism (n, %)	DM (n = 373)	Non-DM (n = 692)	P
Gram-positive	172 (46.1)	259 (37.4)	0.006
Coagulase-negative staphylococcus	103 (27.6)	130 (18.8)	0.001
Staphylococcus aureus	22 (5.9)	26 (3.8)	0.108
Streptococcus species	30 (8.0)	59 (8.5)	0.786
Enterococcus species	8 (2.1)	11 (1.6)	0.514
Other gram-positive	9 (2.4)	33 (4.8)	0.060
Gram-negative	74 (19.8)	170 (24.6)	0.080
Escherichia coli	26 (6.7)	73 (10.5)	0.038
Klebsiella species	6 (1.6)	20 (2.9)	0.196
Acinetobacter baumannii	7 (1.9)	17 (2.5)	0.543
Pseudomonas aeruginosa	5 (1.3)	27 (3.9)	0.020
Other gram-negative	31 (8.3)	32 (4.6)	0.015
Fungi	13 (3.5)	30 (4.3)	0.501
Mycobacterium tuberculosis	2 (0.5)	8 (1.2)	0.508
Polymicrobial	24 (6.4)	55 (7.9)	0.369
Culture-negative	84 (22.5)	163 (23.6)	0.703
No culture	4 (1.1)	7 (1.0)	1.000

DM: Diabetes mellitus.

Table 3 Demographic characteristics and clinical data of 609 peritoneal dialysis-associated peritonitis patients

Variable	DM (n = 214)	Non-DM (n = 395)	P
Demographic characteristics
Age (yr)	61 (54, 68)	55 (42, 68)	0
Gender (male, n, %)	117 (54.7)	185 (48.6)	0.065
No. of PDAP episodes, n (%)			0.596
1	127 (59.3)	230 (58.2)
2	51 (23.8)	86 (21.8)
≥ 3	36 (16.8)	79 (20.0)
CVD	77 (36.0)	104 (26.3)	0.013
Laboratory test
WBC (1012/L)	8.41 (6.90,10.62)	8.26 (5.99,11.29)	0.411
Hb (g/L)	96 (80, 108)	98 (83, 111)	0.089
Alb (g/dL)	28.34 ± 6.74	29.60 ± 5.88	0.017
BUN (mmol/L)	14.9 (10.2, 20.5)	16.0 (12.5, 20.2)	0.062
Scr (μmol/L)	654.7 (480.0, 858.0)	745.3 (575.2, 972.2)	0.001
eGFR	6.46 (4.61, 8.55)	5.51 (4.23, 7.17)	0
PD cell count on admission(/μL)	1799.5 (571.0, 5040.0)	2040 (739.0, 5219.5)	0.330

DM: Diabetes mellitus; PDAP: Peritoneal dialysis-associated peritonitis; CVD: Cardiovascular disease; WBC: White cell count; Hb: Hemoglobin; Alb: Albumin; BUN: Blood urea nitrogen; Scr: Serum creatinine; eGFR: Estimated glomerular filtration rate; PD: Peritoneal dialysis.