Association of hypoglycaemia in screening oral glucose tolerance test in pregnancy with low birth weight fetus

Table 1 Demographics and glycaemic parameters for the cohort categorised by birth weight

	Birth Weight
	< 2500 g (LBW) (n = 96)	2500-4500 g (normal BW) (n = 3346)	> 4500 g (macrosomia) (n = 95)
Maternal age (yr)	28.6 ± 5.6	28.7 ± 5.6	29.0 ± 5.4	P = 0.85
Proportion Asians	29%	15%	1%	P = 0.001
FPG (mmol/L)	4.3 ± 0.6	4.5 ± 0.6	4.7 ± 0.5	P = 0.001
2-h PG (mmol/L)	5.5 ± 1.9	5.8 ± 1.6	5.8 ± 1.3	P = 0.26
Proportion with 2-h PG ≤ 3.5 mmol/L	8.3%	2.8%	4.2%	P = 0.007
HbA1c IFCC (mmol/mol)	34.5 ± 3.4	34.3 ± 4.3	34.3 ± 0.4	P = 0.92

LBW: Low birth weight; FPG: Fasting plasma glucose; 2-h PG: 2 h plasma glucose on the oral glucose tolerance test.

Table 2 Demographics and clinical parameters for the cohorts categorised by 2-h plasma glucose

	2-h PG category (mmol/L)
	Low ( ≤ 3.5) n = 107	Normal (3.6-7.7) n = 3066	High ( ≥ 7.8) n = 364
Maternal age (yr)	27.2 ± 5.8	28.4 ± 5.7	30.6 ± 5.5	P < 0.001
Proportion caucasians (%)	86	82	73	P < 0.001
Birth weight in grams	3357 ± 591	3480 ± 515	3349 ± 459	1P < 0.001
Proportion with LBW (%)	7.5%	2.6%	2.5%	P = 0.008

¹Overall P < 0.001; on post hoc tests there was a significant difference only between the ”low” 2-h PG cohort compared to ”normal” 2-h PG (mean ± SE = 122.9 ± 50.3 g, P = 0.015). There was no difference in the birth weight between ”low” 2-h PG and ”high” 2-h PG cohorts. LBW: Low birth weight; 2-h PG: 2 h plasma glucose on the oral glucose tolerance test.