Relationship between sonographically measured median nerve cross-sectional area and presence of peripheral neuropathy in diabetic subjects

doi:10.4239/wjd.v10.i1.47

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 10, Issue 1

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (10868)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-1) series, Tables (1-6) series.

Item

Count

PDF

388

WORD

3101

HTML

4600

Figures (1-1)

508

Tables (1-6)

272

Sum=8869

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

776

Download

1223

Sum=1999

Jan 15, 2019 (publication date) through Dec 2, 2024

Times Cited of This Article

Times Cited (11)

Journal Information of This Article

Publication Name

World Journal of Diabetes

ISSN

1948-9358

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Case Control Study

World J Diabetes. Jan 15, 2019; 10(1): 47-56
Published online Jan 15, 2019. doi: 10.4239/wjd.v10.i1.47

Table 1 Demographic, anthropometric and clinical characteristics of the study subjects n (%)

Variables	DM, n = 85	HC, n = 85	P-value
Age (yr)
mean ± SD¹	61.7 ± 11.1	60.9 ± 10.3	0.620
< 50 yr	11 (12.9)	11 (12.9)	0.965
50-59 yr	25 (29.4)	27 (31.8)
60-69 yr	22 (25.9)	23 (27.1)
≥ 70 yr	27 (31.8)	24 (28.2)
Gender
Male	44 (51.8)	44 (51.8)	1.000
Female	41 (48.2)	41 (48.2)	1.000
Height (m)¹	1.66 ± 0.08	1.65 ± 0.08	0.473
Weight (Kg)¹	71.3 ± 13.6	65.4 ± 11.5	0.003
BMI (Kg/m²)¹
mean ± SD¹	26.0 ± 5.3	24.1 ± 4.3	0.010
Underweight	3 (3.5)	4 (4.7)	0.072
Normal BMI	35 (41.2)	51 (60.0)
Overweight	31 (36.5)	21 (24.7)
Obese	16 (18.8)	9 (10.6)
Systolic BP (mmHg)¹	129.8 ± 20.7	131.9 ± 24.3	0.557
Diastolic BP (mmHg)¹	84.2 ± 11.5	82.8 ± 13.1	0.404
Total cholesterol (mmHg)¹	4.90	4.78	0.622
FBG (mmol/L)¹	7.00 ± 2.16	5.15 ± 0.06	0.001
HbA1C in % (mean ± SD)	8.69 ± 2.46	-	-
Duration of DM in months median (range)	48.0 (0.3-312)	-	-
Peripheral neuropathy	51 (60)	-	-

¹P values < 0.05 are significant. BMI: Body mass index; SBP: Systolic blood pressure; DBP: Diastolic blood pressure; DM: Diabetes mellitus; FBG: Fasting blood glucose; HbA1c: Glycated haemoglobin.

Table 2 Comparison of median nerve cross-sectional area between diabetics and healthy controls

Median nerve CSA (mm²)		DM, n = 85	HC, n = 85	P-value
Right	Carpal tunnel	12.5 ± 2.5	8.8 ± 1.7	< 0.01
Right	5 cm proximal	8.0 ± 2.0	5.3 ± 1.2	< 0.01
Left	Carpal tunnel	12.3 ± 2.5	8.6 ± 1.7	< 0.01
Left	5 cm proximal	7.9 ± 1.9	5.4 ± 1.4	< 0.001

CSA: Cross sectional area; DM: Diabetic subjects; HC: Healthy control subjects. P values < 0.05 are significant.

Table 3 Comparison of median nerve cross-sectional area between diabetics with and diabetics without diabetic peripheral neuropathy

Median nerve CSA (mm²)	Diabetic peripheral neuropathy		P-value
Median nerve CSA (mm²)	Absent n = 34	Present n = 51	P-value
Carpal tunnel	11.8 ± 2.4	12.9 ± 2.5	0.049
5cm Proximal	8.0 ± 2.2	8.0 ± 2.0	0.856

CSA: Cross sectional area. P values< 0.05 are significant.

Table 4 Comparison of median nerve cross-sectional area between diabetics without diabetic peripheral neuropathy, diabetics with mild diabetic peripheral neuropathy and diabetics with moderate/severe diabetic peripheral neuropathy

Median nerve CSA (mm²)	Peripheral neuropathy			*P-value*
Median nerve CSA (mm²)	Absent (n = 34)	Mild (n = 32)	Moderate/severe (n = 19)	*P-value*
Carpal tunnel	11.8 ± 2.4^a	13.2 ± 2.6^a	12.3 ± 2.1^a	0.062
5 cm Proximal	7.9 ± 2.2^b	8.3 ± 2.2^b	7.6 ± 1.4^b	0.145

CSA: Cross sectional area; DPN: Diabetic peripheral neuropathy; NB: The same alphabets in each row indicate insignificant differences using scheffe post hoc test to evaluate intergroup differences.

Table 5 Comparison of median nerve cross-sectional area between categories of age, gender, duration of diabetes mellitus, and glycemic control at carpal tunnel and 5 cm proximal to the carpal tunnel

		Median nerve CSA (mm²) at CATL
		DM_nonDPN	P-value	DM_DPN	P-value	HC	P-value
Duration of DM	≤ 5 yr	11.4 ± 1.8	0.65	12.9 ± 2.4	0.99	-	-
Duration of DM	> 5 yr	11.8 ± 3.3	0.65	12.9 ± 2.7	0.99	-	-
FBG	≤ 7 mmol/L	11.6 ± 2.3	0.79	13.2 ± 2.9	0.34	-	-
FBG	> 7 mmol/L	11.4 ± 2.0	0.79	12.5 ± 1.8	0.34	-	-
HBA1c	≤ 7%	11.0 ± 1.8	0.45	12.3 ± 2.4	0.20	-	-
HBA1c	> 7%	11.7 ± 2.3	0.45	13.2 ± 2.6	0.20	-	-
Age	≤ 60 yr	11.1 ± 1.9	0.25	12.9 ± 2.3	1.00	8.7 ± 1.5	0.37
Age	> 60 yr	12.0 ± 2.4	0.25	12.9 ± 2.7	1.00	8.4 ± 1.9	0.37
Sex	Female	11.3 ± 1.9	0.62	13.2 ± 2.6	0.42	8.1 ± 1.2	0.02
Sex	Male	11.7 ± 2.4	0.62	12.6 ± 2.4	0.42	9.0 ± 2.0	0.02
		Median nerve CSA (mm²) at 5cmCATL
		DM_nonDPN	P-value	DM_DPN	P-value	HC	P-value
Duration of DM	≤ 5 yr	7.6 ± 1.9	0.87	7.7 ± 1.7	0.13	-	-
Duration of DM	> 5 yr	7.5 ± 1.5	0.87	8.5 ± 2.2	0.13	-	-
FBG	≤ 7 mmol/L	7.5 ± 1.3	0.74	8.2 ± 1.9	0.57	-	-
FBG	> 7 mmol/L	7.7 ± 2.5	0.74	7.9 ± 2.0	0.57	-	-
HBA1c	≤ 7%	7.5 ± 1.4	0.86	7.7 ± 2.2	0.29	-	-
HBA1c	> 7%	7.6 ± 1.9	0.86	8.3 ± 1.8	0.29	-	-
Age	≤ 60 yr	7.3 ± 1.5	0.32	8.4 ± 2.1	0.25	5.5 ± 1.2	0.79
Age	> 60 yr	7.9 ± 2.2	0.32	7.8 ± 1.8	0.25	5.4 ± 1.5	0.79
Sex	Female	7.0 ± 1.4	0.10	7.8 ± 1.7	0.37	4.9 ± 0.7	0.00
Sex	Male	8.0 ± 2.0	0.10	8.3 ± 2.2	0.37	5.9 ± 1.6	0.00

CATL: Carpal tunnel; 5cmCATL: 5 cm proximal to the carpal tunnel; DM_nonDPN: Diabetics without diabetic peripheral neuropathy; DM_DPN: Diabetics without diabetic peripheral neuropathy; HC : Healthy controls. P values < 0.05 are significant.

Table 6 Relationship between median nerve cross-sectional area on ultrasound and clinical/laboratory parameters of the diabetic subjects

Variables	CATL		5cmCATL
Variables	r	P-value	r	P-value
Age	-0.041	0.898	-0.050	0.650
Sex	-0.058¹	0.601	-0.050¹	0.651
Weight	0.094	0.390	-0.041	0.708
Height	0.042	0.703	0.025	0.817
BMI	0.091	0.407	-0.056	0.611
SBP	-0.126	0.251	0.050	0.648
DBP	0.043	0.693	0.050	0.648
TC	0.092	0.402	0.092	0.056
Duration of DM	0.110²	0.318	0.151²	0.167
FBG	-0.059	0.591	0.026	0.811
HbA_1c	-0.012	0.916	0.034	0.758

¹Point-biserial correlation coefficient;

²Spearman correlation coefficient. CATL: Carpal tunnel; 5cmCATL: 5 cm proximal to the carpal tunnel; r: Pearson correlation coefficient;; CSA: Cross sectional area; BMI: Body mass index; SBP: Systolic blood pressure; DBP: Diastolic blood pressure; DM: Diabetes mellitus; FBG: Fasting blood glucose; HbA1c: Glycated haemoglobin P values < 0.05 are significant.

Citation: Attah FA, Asaleye CM, Omisore AD, Kolawole BA, Aderibigbe AS, Alo M. Relationship between sonographically measured median nerve cross-sectional area and presence of peripheral neuropathy in diabetic subjects. World J Diabetes 2019; 10(1): 47-56
URL: https://www.wjgnet.com/1948-9358/full/v10/i1/47.htm
DOI: https://dx.doi.org/10.4239/wjd.v10.i1.47