Molecular mechanisms of insulin resistance in type 2 diabetes mellitus

doi:10.4239/wjd.v1.i3.68

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Jul 15, 2010 (publication date) through Oct 25, 2025

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. Jul 15, 2010; 1(3): 68-75
Published online Jul 15, 2010. doi: 10.4239/wjd.v1.i3.68

Table 1 Causes of insulin receptor substrate-1 serine phosphorylation

mTOR

p70S6 kinase

Amino acids

Hyperinsulinemia

JNK

Stress

Hyperlipidemia

Inflammation

IKK

Inflammation

TNF-α

Obesity

Inflammation

Mitochondrial dysfunction

PKCθ

Hyperglycemia

Diacylglycerol

Inflammation

mTOR: molecular target of rapamycin; JNK: c-Jun N-terminal kinase; IKK: IκB kinase; TNF: tumour necrosis factor; PKC: protein kinase C.

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Citation: Saini V. Molecular mechanisms of insulin resistance in type 2 diabetes mellitus. World J Diabetes 2010; 1(3): 68-75
URL: https://www.wjgnet.com/1948-9358/full/v1/i3/68.htm
DOI: https://dx.doi.org/10.4239/wjd.v1.i3.68