Intercellular adhesion molecule-1 rs5498 in North India: Genetic spark for diabetic retinopathy inflammasome, not yet a clinical beacon

Figure 1 Schematic summary of the editorial scope and key findings. The graphic outlines the research background (intercellular adhesion molecule-1 gene polymorphism and type 2 diabetic retinopathy), the methods employed (North-Indian case-control cohort plus meta-analysis), and the principal results: A population-specific 1.6-fold increase in diabetic retinopathy risk associated with the rs5498 GG genotype in northern Indians, contrasted with the absence of a consistent signal in broader Asian or Caucasian populations. The figure underscores the need for population-tailored genetic risk assessment before clinical translation. ICAM-1: Intercellular adhesion molecule-1.