Diabetic osteoporosis: Focus on ferroptosis as a key player and future prospect in traditional Chinese medicine

doi:10.4239/wjd.119692

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World Journal of Diabetes

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1948-9358

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Diabetes. Jul 15, 2026; 17(7): 119692
Published online Jul 15, 2026. doi: 10.4239/wjd.119692

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Figure 1 Ferroptosis-related signaling pathways regulate bone cell fate and bone metabolism imbalance. BMSC: Bone marrow mesenchymal stem cell; ROS: Reactive oxygen species; OBs: Osteoblasts; OCs: Osteoclasts; FtMt: Ferritin mitochondrial; HG: High glucose; Trf1: Transferrin receptor 1; RANKL: Receptor activator of nuclear factor κB ligand; RUNX2: Runt-related transcription factor 2; Nrf2: Nuclear factor erythroid 2-related factor 2; Keap1: Kelch-like ECH-associated protein 1; TFR: Transferrin receptor; FPN: Ferroportin; GPX4: Glutathione peroxidase 4; SLC7A11: Solute carrier family 7 member 11; PUFA: Polyunsaturated fatty acids; ACSL4: Acyl-CoA synthetase long-chain family member 4; LPCAT3: Lysophosphatidylcholine acyltransferase 3; PUFA-PL: Polyunsaturated fatty acid-containing phospholipids; LOXs: Lipoxygenases; LIP: Labile iron pool; DMT1: Divalent metal transporter 1; ZIP8/14: Zrt/Irt-like protein 8/14.

Citation: Geng XR, Liu Y. Diabetic osteoporosis: Focus on ferroptosis as a key player and future prospect in traditional Chinese medicine. World J Diabetes 2026; 17(7): 119692
URL: https://www.wjgnet.com/1948-9358/full/v17/i7/119692.htm
DOI: https://dx.doi.org/10.4239/wjd.119692

Geng XR, Liu Y. Diabetic osteoporosis: Focus on ferroptosis as a key player and future prospect in traditional Chinese medicine. World J Diabetes 2026; 17(7): 119692 [DOI: 10.4239/wjd.119692]

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