Insulin therapy in type 2 diabetes: Insights into clinical efficacy, patient-reported outcomes, and adherence challenges

Figure 1 Dissociation of the insulin hexamers in long-acting (degludec) and rapid-acting (aspart). Slow dissociation of insulin degludec multi hexamers results in prolongation of onset and duration while rapid dissociation of insulin aspart hexamer results in fast onset and short duration of action. Created with BioRender.com (Supplementary material).

Figure 2 Basal and bolus insulin analogs with their structural modifications. Created with BioRender.com (Supplementary material).