Lonardo A, Jamalinia M, Weiskirchen R. Type 2 diabetes, sex and metabolic dysfunction-associated steatotic liver disease. World J Diabetes 2026; 17(5): 119756 [DOI: 10.4239/wjd.v17.i5.119756]
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05278719
Submitted on:
May 12, 2026, 06:30
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Reader Comments:
Dearly respected Editor
Greetings
The authors touched an important topic in metabolic disease, metabolic-associated fatty liver disease (MAFLD) is common in particular in patients with type 2 diabetes mellitus which is approaching an epidemic. Nearly two-thirs of patients wirh diabetes are suffering from from MASLD with seroius consequences in terms of liver cirrhosis, hepatocellular carcinoma, and mortality. In addition, patients with MASLD have higher prevalence of type 2 diabetes. The current literatures shows significant geographic, age, and gender variation. Importantly, males had a higher rate of MASLD than women, but the mortality is higher in women. Although, the variation can be explained in part by the differences in hypertension, serum uric acid, and other cardiovascular risk factors. Genetic and sex hormone in particular sex-hormone binding globulins play important roles. Investigating the gender differences could direct personalized management specific for age and gender. This is an important hot topic in Medicine on which Iam very thrilled to write an editorial or an umbrella review.
Best regards
Hyder Mirghani, Peofessor of Internal Medicie, Endocrinology, and Metabolism, University of Tabuk, Saudi Arabia
Author's Reply:
Replied on May 21, 2026, 13:48
Dear Professor Mirghani,
On behalf of my co-authors, I would like to extend our sincere gratitude for your favorable evaluation of our manuscript.
We would also like to draw your kind attention to our series of articles addressing sex differences in this field and related areas, which may be of interest to you.
With my kindest regards,
Amedeo Lonardo, M.D.