Chen J, Zhang WC, Tang XQ, Yin RH, Wang T, Wei XY, Pan CJ. Predictive value of bilirubin and serum γ-glutamyltranspeptidase levels in type-2 diabetes mellitus patients with acute coronary syndrome. World J Diabetes 2024; 15(1): 34-42 [PMID: 38313856 DOI: 10.4239/wjd.v15.i1.34]
Reader's ID:
06368927
Submitted on:
January 31, 2024, 12:47
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Reader Comments:
I read with great interest the manuscript by Chen J et al. analysing the prognostic value of simple biomarkers bilirubin and serum γ-glutamyltranspeptidase levels in type-2 diabetes mellitus patients with acute coronary syndrome. The paper discusses a rather unexplored topic and the authors have provided their suggestions subsequent to their findings.
However there are major concerns which could help improve the quality of research in this field in future by the authors or other researchers worldwide.
1) The overall quality of englight language is suboptimal with inappropriate choice of words at many places.
2) The study design is inherently prone to unaccounted biases and the hence the study has to be validated in larger prospective and randomised studies
3) There is confusion regarding the study population selection. Were they consecutive patients or randomly chosen. This may have significantly altered the results.
4) The description of sample size should have been mentioned considering this was a retrospective study.
5) The authors could have followed all participants for 3 months and then compared the outcomes. Why did they only choose DM + ACS and not ACS alone per say. Does bilirubin and serum γ-glutamyltranspeptidase metabolism differ in DM?
6) The rationale of choosing these should have been further explained in greater detail. Giving 1-2 prior studies and their results is not sufficient.
7) overall I do not see how this study can be applicable in clinical practice. Small numbers, retrospective data with likely confounders unaccounted for limit is value in its current form. Perhaps the authors can take these suggestions and further explore the value of these biomarkers in real world setting.
Reply from the Editorial Office:
First, thank you very much for your professional comments on the article published in World Journal of Diabetes.
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Finally, we look forward to receiving your high-quality Letter to the Editor, which will promote academic communication and lead the development of this discipline.