Li YY, Tong LP, Wu XD, Lin D, Lin Y, Lin XY. Analysis of influencing factors and interaction of body weight and disease outcome in patients with prediabetes. World J Diabetes 2023; 14(10): 1551-1561 [PMID: 37970128 DOI: 10.4239/wjd.v14.i10.1551]
Reader's ID:
06546141
Submitted on:
October 18, 2023, 16:21
Reader Expertise:
Reader’s expertise on the topic of the manuscript
Conflicts-of-Interest Statement:
Does the reader have a conflict of interest?
Reader Comment Standards for Published Articles:
1 Title
Does the title reflect the main subject/hypothesis of the manuscript?
2 Abstract
Does the abstract summarize and reflect the work described in the manuscript?
3 Key Words
Do the key words reflect the focus of the manuscript?
4 Background
Does the manuscript adequately describe the background, present status and significance of the study?
5 Methods
Does the manuscript describe methods (e.g., experiments, data analysis, surveys, and clinical trials, etc.) in adequate detail?
6 Results
Are the research objectives achieved by the experiments used in this study?
Has the study made meaningful contributions towards research progress in this field?
7 Discussion
Does the manuscript interpret the findings adequately and appropriately, highlighting the key points concisely, clearly and logically?
Are the findings and their applicability/relevance to the literature stated in a clear and definite manner?
Is the Discussion accurate and does it discuss the paper’s scientific significance and/or relevance to clinical practice sufficiently?
8 Illustrations and Tables
Are the figures, diagrams and tables sufficient, good quality and appropriately illustrative of the paper contents?
Do figures require labeling with arrows, asterisks, etc., or better legends?
9 Biostatistics
Does the manuscript meet the requirements of biostatistics?
10 Units
Does the manuscript meet the requirements of use of SI units?
11 References
Does the manuscript appropriately cite the latest, important and authoritative references in the Introduction and Discussion sections?
Does the author self-cite, omit, incorrectly cite and/or over-cite references?
12 Quality of manuscript organization and presentation
Is the manuscript concisely and coherently organized and presented?
Are the style, language and grammar accurate and appropriate?
13 Ethics statements
For all manuscripts involving human studies and/or animal experiments, author(s) must submit the related formal ethics documents that were reviewed and approved by their local ethical review committee. Did the manuscript meet the requirements of ethics?
Scientific Quality:
The overall quality of the manuscript, based on the above-listed criteria, should be evaluated and classified according to the following five categories
Language Quality:
Language quality (style, grammar, and spelling) should be evaluated and classified according to the following five categories.
Reader Comments:
In this manuscript, the authors have conducted a significant study on prediabetes and its progression to Type 2 diabetes mellitus (T2DM), with a particular focus on the impact of body weight. The study's findings are relevant in the context of the growing global prevalence of T2DM and its associated complications.
The study has several strengths, including a well-defined selection of patients with prediabetes based on Chinese diagnostic criteria. The research demonstrates the importance of early intervention in preventing the progression of prediabetes to T2DM. Furthermore, the study identifies specific factors, such as body weight, glycosylated hemoglobin, uric acid, fasting insulin (FINS), and homeostatic model assessment for insulin resistance (HOMA-IR), as independent factors influencing this progression. The discovery of a multiplicative interaction between body weight and uric acid adds a valuable dimension to the understanding of this process.
However, it's essential to consider and address the differences in diagnostic criteria between the Chinese guidelines used in this study and the American Diabetes Association (ADA) guidelines. The ADA guidelines emphasize the A1C test, fasting plasma glucose (FPG) test, and oral glucose tolerance test (OGTT) to diagnose prediabetes and diabetes. This variation in criteria should be acknowledged to provide context for interpreting the study's findings in an international context.
The study's conclusion underscores the importance of weight management and the potential risks associated with high body weight and elevated uric acid levels in prediabetic patients. The recommendation for clinical vigilance and timely intervention for patients with these risk factors is valuable.
Reply from the Editorial Office:
First, thank you very much for your professional comments on the article published in World Journal of Diabetes.
Second, we read your comments with great interest. You are welcome to format your valuable comments into a Letter to the Editor and submit it online to World Journal of Diabetes at https://www.f6publishing.com. There are no restrictions on the number of words, figures (color, B/W) or authors for a Letter to the Editor. In addition, the article processing charge will be exempted for this Letter to the Editor. As with all articles published by the Baishideng Publishing Group, the Letter to the Editor will be published online after completing peer review. The guidelines for a Letter to the Editor can be found at: https://www.wjgnet.com/bpg/GerInfo/219.
Finally, we look forward to receiving your high-quality Letter to the Editor, which will promote academic communication and lead the development of this discipline.