04046740

October 28, 2023, 14:52

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We read with great interest a review on “Gut microbiome supplementation as therapy for metabolic syndrome” by Antony MA et al[1]. A conclusion that microbiome supplementation can increase the number of beneficial microbes and reduce harmful microbes in the gut of patients with diabetes and metabolic syndrome . Data from the past decade suggest that with the rise of the microbiome field, it is possible that mechanisms contributing to risk factors for metabolic syndrome are coming from the gut [2]. Disruption of the gut barrier may lead to systemic chronic inflammation, which in turn leads to organ dysfunction and ultimately host metabolic disease [3].Interactions between the gut microbiota and host metabolism have been shown to be mediated by a variety of factors including gut barrier defects, bile acid metabolism, antibiotic use, and the pleiotropic effects of metabolites produced by microbes[2]. The gut microbiome can influence host metabolism through its metabolites: 1. SCFA are microbially derived biologically active by-products that interact with host metabolism in a complex manner[2].2. Tetrahydroxanthohumol (TXN) attenuates diet-induced obesity and adverse phenotypic outcomes of metabolic syndrome primarily by reducing the number of pro-inflammatory gut microbes[4].3.Polyphenols (PPs) are naturally occurring bioactive compounds with antioxidant capacity and ROS reduction, which play an important role in human nutrition.PPs are metabolised in the gut; therefore, prolonged retention of PPs in the gut can have beneficial effects on the gut microbiota, which also enhances the bioactivity of PPs by biotransforming them into active metabolites, thus contributing to the improvement of overall gut microbial activity, thus contributing to the improvement of overall gut health[5].4. polymethoxyflavone-rich extracts (PMFE) from citrus may modulate amino acid metabolism by regulating the gut microbiota to make it healthier, thereby reducing the incidence of metabolic syndrome[6]. The ability of fecal microbiota transplantation to transfer a metabolically healthy microbiome into recipients with MetS to achieve a healthy phenotype has been demonstrated in many rodent studies[2].A double-blind, randomised, placebo-controlled trial has shown that gut phages from healthy donors can temporarily alter the gut microbiota in patients with metabolic syndrome [7]. In summary, the gut microbiota influences host metabolism through multiple mechanisms of action, and thus the gut microbiota may be a potential target for the treatment of metabolic syndrome. However, further studies are needed to deepen our understanding of the role of the gut microbiota in the prevention and treatment of metabolic syndrome.

First, thank you very much for your professional comments on the article published in World Journal of Diabetes. Second, we read your comments with great interest. You are welcome to format your valuable comments into a Letter to the Editor and submit it online to World Journal of Diabetes at https://www.f6publishing.com. There are no restrictions on the number of words, figures (color, B/W) or authors for a Letter to the Editor. In addition, the article processing charge will be exempted for this Letter to the Editor. As with all articles published by the Baishideng Publishing Group, the Letter to the Editor will be published online after completing peer review. The guidelines for a Letter to the Editor can be found at: https://www.wjgnet.com/bpg/GerInfo/219. Finally, we look forward to receiving your high-quality Letter to the Editor, which will promote academic communication and lead the development of this discipline.

04621382

October 18, 2023, 05:38

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Dear Editor Greetings The manuscript touched on an important topic, in Medicine, the gut microbiota has been linked to various diseases including cardio-metabolic, gastrointestinal, and cancer. Studies of prebiotics, probiotics, synbiotics, and postbiotics showed conflicting results regarding the metabolic syndrome. Biotics source, the mode of administration (the oral route), and their interaction with the gut environment might explain the contradicting data. An important further step is fecal microbiota transplantation which showed great promise when given by colonoscopy in contrast to the upper route. Gastric enzymes, gut hormones, and environment might play an important role regarding the efficacy of biotics. The evidence of the efficacy of gut microbiota transplantation on diabetes, obesity, and dyslipidemia (when administered through the lower gastrointestinal tract) p[pointed to the role of upper GIT. In addition, barbaric surgery was found to be effective in diabetes remission, weight reduction, and hypertension remission might be explained in part by gut microbiota dysbiosis and gut hormones. Therefore, shining the light on gut microbiota transplantation and comparing its effects with biotics is of great importance. Hyder Mirghani, Professor of Internal Medicine and Endocrine, University of Tabuk, Saudi Arabia I would like to submit an editorial on this important topic.

First, thank you very much for your professional comments on the article published in World Journal of Diabetes. Second, we read your comments with great interest. You are welcome to format your valuable comments into a Letter to the Editor and submit it online to World Journal of Diabetes at https://www.f6publishing.com. There are no restrictions on the number of words, figures (color, B/W) or authors for a Letter to the Editor. In addition, the article processing charge will be exempted for this Letter to the Editor. As with all articles published by the Baishideng Publishing Group, the Letter to the Editor will be published online after completing peer review. The guidelines for a Letter to the Editor can be found at: https://www.wjgnet.com/bpg/GerInfo/219. Finally, we look forward to receiving your high-quality Letter to the Editor, which will promote academic communication and lead the development of this discipline.