Xia F, Wen LP, Ge BC, Li YX, Li FP, Zhou BJ. Gut microbiota as a target for prevention and treatment of type 2 diabetes: Mechanisms and dietary natural products. World J Diabetes 2021; 12(8): 1146-1163 [PMID: 34512884 DOI: 10.4239/wjd.v12.i8.1146]
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04740911
Submitted on:
September 07, 2021, 09:51
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Reader Comments:
The authors report the effects of dietary natural products on gut microbiota and associated mechanisms in diabetes mellitus, however the authors describe the fruits, vegetables, herbs, and other plant foods.
Why the author does not mention animal or fish products. e.g. milk, kefir, products with omega acids or vitamin D,
Reply from the Editorial Office:
Thank you very much for your comments.
Reader's ID:
06134129
Submitted on:
September 02, 2021, 07:37
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Reader Comment Standards for Published Articles:
1 Title
Does the title reflect the main subject/hypothesis of the manuscript?
2 Abstract
Does the abstract summarize and reflect the work described in the manuscript?
3 Key Words
Do the key words reflect the focus of the manuscript?
4 Background
Does the manuscript adequately describe the background, present status and significance of the study?
5 Methods
Does the manuscript describe methods (e.g., experiments, data analysis, surveys, and clinical trials, etc.) in adequate detail?
6 Results
Are the research objectives achieved by the experiments used in this study?
Has the study made meaningful contributions towards research progress in this field?
7 Discussion
Does the manuscript interpret the findings adequately and appropriately, highlighting the key points concisely, clearly and logically?
Are the findings and their applicability/relevance to the literature stated in a clear and definite manner?
Is the Discussion accurate and does it discuss the paper’s scientific significance and/or relevance to clinical practice sufficiently?
8 Illustrations and Tables
Are the figures, diagrams and tables sufficient, good quality and appropriately illustrative of the paper contents?
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9 Biostatistics
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11 References
Does the manuscript appropriately cite the latest, important and authoritative references in the Introduction and Discussion sections?
Does the author self-cite, omit, incorrectly cite and/or over-cite references?
12 Quality of manuscript organization and presentation
Is the manuscript concisely and coherently organized and presented?
Are the style, language and grammar accurate and appropriate?
13 Ethics statements
For all manuscripts involving human studies and/or animal experiments, author(s) must submit the related formal ethics documents that were reviewed and approved by their local ethical review committee. Did the manuscript meet the requirements of ethics?
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Language quality (style, grammar, and spelling) should be evaluated and classified according to the following five categories.
Reader Comments:
1.The first line in Introduction, viz., Diabetes mellitus (DM) is characterized by hyperglycemia and insufficient insulin secretion and/or dysfunction, should be reworded as Diabetes mellitus (DM) is characterized by hyperglycemia and insufficient insulin secretion and/or insulin resistance, and beta-cell dysfunction.
2.The second section title, viz., ALTERNATION OF GUT MICROBIOTA IN T2DM, should read as ALTERATION OF GUT MICROBIOTA IN T2DM.
3.IN FIGURE 1, THERE IS MENTION OF WHITE/BROWN ADIPOSE TISSUE, WHAT ABOUT BEIGE OR BRITE (BROWN AND WHITE) ADIPOSE TISSUE?
4.Rapamycin is so named because it was isolated from an island called Rapa Nui by an Indian (Sehgal).
5.Well written and comprehensive with 136 references.
6.Some questions for the authors:
A. So many articles have been written on gut microbiota and diabetes, yet none of the major diabetes guidelines mention the use of probiotics, prebiotics, or synbiotics to treat diabetes. Is it because we need more human data from RCCTs? How do you propose to get diabetes societies to include this topic in the next version of their guidelines?
B. Just as there is glucotoxicity and lipotoxicity, what about amino acid toxicity? After all, diabetes is a metabolic disorder affecting all 3 macronutrients.
Reply from the Editorial Office:
First, thank you very much for your professional comments on the article published in World Journal of Diabetes.
Second, we read your comments with great interest. You are welcome to format your valuable comments into a Letter to the Editor and submit it online to World Journal of Diabetes at https://www.f6publishing.com. There are no restrictions on the number of words, figures (color, B/W) or authors for a Letter to the Editor. In addition, the article processing charge will be exempted for this Letter to the Editor. As with all articles published by the Baishideng Publishing Group, the Letter to the Editor will be published online after completing peer review. The guidelines for a Letter to the Editor can be found at: https://www.wjgnet.com/bpg/GerInfo/219.
Finally, we look forward to receiving your high-quality Letter to the Editor, which will promote academic communication and lead the development of this discipline.
Author's Reply:
Replied on September 06, 2021, 04:05
Thank you for you comments. Indeed, as of now, none of the major diabetes guidelines have any recommendations or suggestions for the treatment of gut microbiota in diabetes. Personally, I think that the mechanism of action is not very clear, and it involves the influence of intestinal microorganisms in the human metabolic process on the one hand, especially the causal relationship between the two to be elucidated.