Colon capsule endoscopy: Advantages, limitations and expectations. Which novelties?

Table 1 Results of PillCam colon trials

	n	S (%)	E (%)	PPV (%)	NPV (%)
Results for polyps (any size)
Eliakim et al[8] 2006	91	69	81	74	78
Schoofs et al[9] 2006	41	76	64	83	54
Van Gossum et al[21] 2009	320	72	78	-	-
Eliakim et al[10] 20091	98	88	-	-	-
Results for significant polyps (≥ 6 mm or > 3 polyps > 3 mm)
Eliakim et al[8] 2006	91	63	94	67	91
Schoofs et al[9] 2006	41	60	73	46	83
Van Gossum et al[21] 2009	320	64	84	-	-
Eliakim et al[10] 20091	98	89	76	-	-
Spada et al[24] 20111	109	84	64	-	-
Results for polyps ≥ 10 mm
Eliakim et al[10] 20091	98	88	89	-	-
Spada et al[24] 20111	109	88	95	-	-
Results for other lesions	-	-	-	-	-
Schoofs et al[9] 2006	41	76	63	82	52
Eliakim et al[8] 2006	91	78	76	47	93
Van Gossum et al[21] 2009	320	76	-	-	-

¹The second generation of PillCam colon capsule endoscopy. S: Sensitivity; E: Specificity; PPV: Positive predictive value; NPV: Negative predictive value.

Table 2 Usual regimen of preparation for PillCam colon capsule endoscopy: Colon preparation regimen described by Schoofs et al[9]

Day	Time	Action
−1	All day	Liquid diet only
	6:00 pm–9:00 pm	3 L PEG
Exam day	6:00 am–7:00 am	1 L PEG
	7.45 am	Domperidone (20 mg)
	8:00 am	PillCam ingestion
	10:00 am	45 mL NaP + 1 L water1
	02:00 pm	30 mL NaP + 1 L water
	03:00 pm	Snack (optional)
	4.30 pm	10 mg Bisacodyl (suppository)

¹After verifying capsule exit from the stomach. PEG: Polyethylene glycol; NaP: Sodiumphosphate.

Table 3 Colon preparation regimen described by Eliakim et al[8]

Day	Time	Action
−1	All day	Liquid diet only
	7:00 pm–9:00 pm	2 L PEG
Exam day	8:00 am–9:00 am	2 L PEG
	10:00 am	PillCam ingestion1
	1st booster (at small bowel detection)	30 mL NaP + 1 L water
	2nd booster (3 h after 1st booster)	15 mL NaP + 0.5 L water
	Suppository (2 h after 2nd booster)	10 mg Bisacodyl (suppository)

¹10 mg metoclopramide administered if capsule delayed in stomach 1 h. PEG: Polyethylene glycol; NaP: Sodium phosphate.

Table 4 Novel regimen of colon preparation proposed from Spada et al[24]

Day	Time	Action
−5 to −2	All day	Low fibre diet
−2	08:00 pm	4 senna tablets (48mg)
−1	All day	Liquid diet only
	7:00 pm–9:00 pm	2 L PEG
Exam day	6:00 am–8:00 am	2 L PEG
	8:45 am	Domperidone (20 mg)
	9:00 am	PillCam ingestion
	11:00 am	30 mL NaP + 1 L water1
	02:00 pm	15 mL NaP + ½ L water
	04:00 pm	10 mg Bisacodyl (suppository)
	07:00 pm	Colonoscopy

¹After verifying capsule exit from the stomach; PEG: Polyethylene glycol; NaP: Sodium phosphate.