Management of bleeding and artificial gastric ulcers associated with endoscopic submucosal dissection

Table 1 Delayed bleeding rate of endoscopic submucosal dissection for gastric epithelial neoplasia

Author	Year	Total cases	Delayed bleeding (%)	En bloc resection rate (%)
Oda et al[48]	2005	945	6	93
Kakushima et al[49]	2006	383	3.4	91
Imagawa et al[18]	2006	196	0	93
Onozato et al[50]	2006	171	7.6	94
Oka et al[16]	2006	195	6.2	83
Hirasaki et al[51]	2007	112	7.1	96
Ono et al[6]	2008	161	8.7	99
Hoteya et al[52]	2009	572	4.9	95
Isomoto et al[53]	2009	510	1.8	95
Tsuji et al[54]	2010	398	5.8	NA
Akasaka et al[28]	2011	1188	3.1	95

NA: Not analyzed.

Table 2 Healing process of gastric artificial ulcers after endoscopic submucosal dissection

Author	Year	Total cases	Drugs administration	Weeks	Ulcer healing rate (%)		Average ulcer size
					4 wk	8 wk	Maximal diameter (mm)	Resected area (mm2)
Kakushima et al[71]	2004	70	PPI + sucralfate	8	NA	100	34.7	NA
Lee et al[76]	2004	26	OPZ 20 mg	1	12	NA	NA	503
		34	OPZ 20 mg	4	15	NA	NA	575
Yamaguchi et al[78]	2005	29	OPZ 20 mg	8	NA	NA	27.8	NA
		28	Famotidine 40 mg	8	NA	NA	22.4	NA
Uedo et al[79]	2007	73	RPZ 20 mg	8	NA	83	41	NA
		70	Cimetidinde 800 mg	8	NA	89	40.5	NA
Asakuma et al[80]	2009	28	RPZ 20 mg + ES 3.0 g	8	40.7	96.3	NA	1306
		28	RPZ 20 mg	8	11.5	76.9	NA	1274
Kato et al[81]	2010	31	RPZ 10 mg + rebamipide 300 mg	4	68	NA	35	NA
		31	RPZ 10 mg	4	35	NA	31	NA
Fujiwara et al[82]	2011	30	RPZ 20 mg + rebamipide 300 mg	8	NA	86.7	41	1453
		31	RPZ 20 mg	8	NA	54.8	42.8	1521
Niimi et al[77]	2011	55	RPZ 10 mg	2	NA	80.0	32.7	NA

NA: Not analyzed; PPI: Proton pump inhibitor; OPZ: Omeprazole; RPZ: Rabeprazole; ES: Ecabet sodium.