Moderate sedation with midazolam and propofol is as safe as propofol monotherapy for colonoscopy, but more cost-effective

Table 1 Patient characteristics, mean ± SD/median (interquartile range)

	Propofol combination therapy	Propofol monotherapy	P value
Intervention	2.5 mg midazolame + propofol	Propofol monotherapy
Number of patients	60 (female 30, male 30)	60 (female 29, male 31)
Age (years)	55.5 (50-69)	57 (50-69)	0.96
BMI (kg/m2)	25.4 ± 3.37	26 ± 3.03	0.33

BMI: Body mass index.

Table 2 Relevant results, mean ± SD

	Propofol combination therapy	Propofol monotherapy	P value
Dose of propofol (mg)	65 ± 21	217 ± 61	< 0.01
Duration of examination (minute)	21.4 ± 6	18.6 ± 6	0.02
Duration until discharge (minute)	49.4 ± 17	57.7 ± 26	0.04

Table 3 Costs per patient (Euro)

	Propofol combination therapy	Propofol monotherapy	P value
Mean cost per mililiter	2.87	8.01	< 0.01
Mean costs per 5 mL syringe propofol	3.69	8.55	< 0.01
Mean costs per 10 mL syringe propofol	4.31	9.20	< 0.01