Predictor of respiratory disturbances during gastric endoscopic submucosal dissection under deep sedation

Table 1 Patient characteristics and details of endoscopic submucosal dissection

	n	%
Gender
Male	24	68.6
Female	11	31.4
Age in yr	73.2 ± 10.2
BMI in kg/m2	23.0 ± 3.7
Score of STOP questionnaire
0	6	19.4
1	11	35.5
2	9	29
3	4	12.9
4	1	3.2
Total dose of propofol in mg/h	9.8 ± 3.8
Sedation period in min	107.6 ± 44.0

Data are presented as mean ± standard deviation unless otherwise indicated. BMI: Body mass index.

Table 2 Relationship between preoperative apnea-hypopnea index and intraoperative apnea-hypopnea index

	n (%)	Preoperative AHI	Intraoperative AHI	P value
All patients	35	9.25 ± 11.03	12.76 ± 7.59	0.049
SAS
Negative	18 (51.4)	2.55 ± 1.40	9.29 ± 5.37b	< 0.001
Positive	17 (48.6)	16.34 ± 12.35	16.44 ± 7.99	NS
Mild	9 (52.9)	8.41 ± 2.37	15.21 ± 8.08	0.042
Moderate	6 (35.3)	18.55 ± 3.35	15.58 ± 7.60	NS
Severe	2 (11.8)	45.40 ± 7.35	24.57 ± 7.67	NS

Data are presented as mean ± standard deviation unless otherwise indicated.

^bP = 0.017, SAS negative vs positive. AHI: Apnea-hypopnea index; SAS: Sleep apnea syndrome; NS: Not significant.

Table 3 Intraoperative apnea-hypopnea index and single regression analysis of each item

	P value	R2
Preoperative AHI	0.0068	0.2016
Age	0.0272	0.1393
BMI	0.0299	0.1350
STOP questionnaire	0.0375	0.1408
Dose of propofol	0.0783	0.0910
Gender	0.2048	0.0483

AHI: Apnea-hypopnea index; BMI: Body mass index.

Table 4 Multiple regression analysis comparing intraoperative apnea-hypopnea index and each item (excluding STOP questionnaire score)

	Partial regression coefficient			Standardized regression coefficient
	B	Standard error		β	t	P value
Intercept	24.273	9.215		0	2.63	0.0129
Preoperative AHI	0.252	0.111		0.366	2.28	0.0296
Age	-0.189	0.120		-0.254	-1.58	0.1240

AHI: Apnea-hypopnea index.

Table 5 Multiple regression analysis comparing intraoperative apnea-hypopnea index and each item (excluding preoperative apnea-hypopnea index)

	Partial regression coefficient			Standardized regression coefficient
	B	Standard error		β	t	P value
Intercept	34.319	8.401		0	4.09	0.0003
STOP questionnaire	3.306	1.134		0.444	2.92	0.0069
Age	-0.364	0.116		-0.477	-3.13	0.0040