Endoscopic ultrasound-through-the-needle biopsy in pancreatic cystic lesions: A large single center experience

Table 1 Patient characteristics

Patient characteristics
Age, mean ± SD, yr	66.9 ± 11.7
Sex, male/female	26/30
Cyst size, mm	28.8 (12-85)
Location
Uncinate	4
Head	13
Neck	16
Body	7
Tail	16
Biopsy times	3.14 (1-6)
Pre-biopsy clinical diagnosis
Intraductal papillary mucinous neoplasm	31
Unknown	18
Pseudocyst	5
Mucinous cystadenoma	1
Neuroendocrine tumor	1

Table 2 Results of endoscopic guided through the needle biopsy

Technical success	100% (56/56)
Clinical success	80.4% (45/56)
Adverse events	3.6% (2/56)
Histopathological diagnosis by EUS-TTNB
IPMN	32
Pseudocyst	4
Serous cyst neoplasm	4
Neuroendocrine tumor	2
Adenocarcinoma	2
Paraganglioma	1
Inconclusive	11
Subtyping of IPMN (n = 32)
Gastric type	19
Pancreatobiliary type	4
Inconclusive	9

IPMN: Intraductal papillary mucinous neoplasm; EUS-TTNB: Endoscopic ultrasound-through-the-needle biopsy.

Table 3 Comparison between endoscopic ultrasound-fine-needle aspiration and endoscopic ultrasound-through-the-needle biopsy

	EUS-FNA	EUS-TTNB	P value
Clinical success	25% (14/56)	80.4% (45/56)	< 0.001
Mucinous cyst diagnosis in cysts > CEA 192 ng/mL	12% (3/25)	52% (13/25)	0.005
Mucinous cyst diagnosis in cysts < CEA 192 ng/mL	15.4% (2/13)	76.9% (10/13)	0.005

EUS-FNA: Endoscopic ultrasound-fine-needle aspiration; EUS-TTNB: Endoscopic ultrasound-through-the-needle biopsy; CEA: Carcinoembryonic antigen.