Use of volumetric laser endomicroscopy for dysplasia detection at the gastroesophageal junction and gastric cardia

Figure 1 Inclusion and exclusion criteria flowchart. VLE: Volumetric laser endomicroscopy; GEJ: Gastroesophageal junction.

Figure 2 Correlating histology. A: Normal gastric cardia with regular gastric pit architecture; B: Inflamed gastric cardia with chronic inflammatory infiltrate and loss of structured gastric pits; C: Low grade dysplasia in Barrett’s mucosa with a prominent atypical septated gland; D: High grade dysplasia with cytologic and architectural atypia extending to the surface.

Figure 3 Volumetric laser endomicroscopy imaging snapshots. A: Normal gastric cardia with gastric rugae and gastric pit architecture; B: Inflamed gastric cardia with loss of gastric pit architecture and anomalous glands; C: Low grade dysplasia with loss of gastric pit architecture, heterogeneous scattering, anomalous septated gland; D: High grade dysplasia with irregular surface and anomalous glands.