Krishnan A. Leucine-rich alpha-2 glycoprotein for detecting small bowel lesions in Crohn’s disease: A critical review and the path forward. World J Gastrointest Endosc 2025; 17(4): 106671 [PMID: 40291129 DOI: 10.4253/wjge.v17.i4.106671]
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05755618
Submitted on:
April 17, 2025, 05:18
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Reader Comments:
Leucine-rich α2 glycoprotein (LRG) is a biomarker easily and conveniently evaluated through blood sampling. Because LRG reflects cytokines other than IL-6, it is expected to be useful for assessing the activity of small intestinal lesions in Crohn’s disease, which are often difficult to detect with CRP. Although there is still room for discussion regarding the cutoff value of LRG, it is considered more important to monitor the trend of LRG values over time in each patient rather than focusing solely on the absolute value itself.
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