Basic Study
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. May 26, 2015; 7(4): 776-788
Published online May 26, 2015. doi: 10.4252/wjsc.v7.i4.776
Fetal kidney stem cells ameliorate cisplatin induced acute renal failure and promote renal angiogenesis
Ashwani Kumar Gupta, Sachin H Jadhav, Naresh Kumar Tripathy, Soniya Nityanand
Ashwani Kumar Gupta, Sachin H Jadhav, Naresh Kumar Tripathy, Soniya Nityanand, Stem Cell Research Facility, Department of Hematology, Sanjay Gandhi Post-Graduate Institute of Medical Sciences, Lucknow 226014, India
Author contributions: Gupta AK designed and performed the experiments and analyzed the data; Jadhav SH, Tripathy NK and Nityanand S designed the study and analyzed the data; Nityanand S provided the reagents and analytical tools; Gupta AK, Jadhav SH, Tripathy NK and Nityanand S wrote the manuscript.
Correspondence to: Dr. Soniya Nityanand, MD, PhD, FNASc, FASc, Professor and Head, Department of Hematology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Rae Bareli Road, Lucknow 226014, India. soniya_nityanand@yahoo.co.in
Telephone: +91-522-2494291 Fax: +91-522-2668017
Received: November 13, 2014
Revised: February 5, 2015
Accepted: March 5, 2015
Published online: May 26, 2015
Processing time: 199 Days and 16.6 Hours
Core Tip

Core tip: This study provides novel data on the therapeutic effect of culture expanded fetal kidney stem cells (fKSC) in acute renal failure (ARF). The fKSC represent primitive renal stem cells that express mesenchymal and renal progenitor markers. They exhibit in vitro angiogenesis and potential to differentiate into renal epithelial cells. On administration in ARF rats, they rapidly improve renal function and histology. The therapeutic effects of fKSC are accompanied with increased capillary density in kidney tissues suggesting that induction of renal angiogenesis may be an important therapeutic mechanism of these stem cells.