Inhibition of glutathione metabolism can limit the development of pancreatic cancer

doi:10.4252/wjsc.v14.i5.362

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May 26, 2022 (publication date) through Mar 11, 2026

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World Journal of Stem Cells

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World J Stem Cells. May 26, 2022; 14(5): 362-364
Published online May 26, 2022. doi: 10.4252/wjsc.v14.i5.362

Inhibition of glutathione metabolism can limit the development of pancreatic cancer

Pei-Yuan Cai, Mei-Lin Ma, Yang-Fen Zhang, Zi-Xuan Zhou, Yan Wang, Lian-Ping He, Wei Wang

Pei-Yuan Cai, Wei Wang, Department of Interventional Oncology, Municipal Hospital Affiliated to Taizhou University, Taizhou 318000, Zhejiang Province, China

Mei-Lin Ma, Yang-Fen Zhang, Zi-Xuan Zhou, Yan Wang, Lian-Ping He, School of Medicine, Taizhou University, Taizhou 318000, Zhejiang Province, China

Author contributions: Wang W and He LP contributed to conceptualization and formal analysis; Cai PY, Ma ML, Zhang YF, Wang Y, and Zhou ZX contributed to writing of the original draft, writing, reviewing, and editing; All authors participated in drafting the manuscript and have read, contributed to, and approved the final version of the manuscript.

Conflict-of-interest statement: The authors declare that they have no conflict of interest.

Corresponding author: Wei Wang, MD, Attending Doctor, Department of Interventional Oncology, Municipal Hospital Affiliated to Taizhou University, No. 381-1 Zhongshan East Road, Jiaojiang District, Taizhou 318000, Zhejiang Province, China. westernfox000@163.com

Received: December 13, 2021
Peer-review started: December 13, 2021
First decision: March 13, 2022
Revised: March 15, 2022
Accepted: April 27, 2022
Article in press: April 27, 2022
Published online: May 26, 2022
Processing time: 163 Days and 22.7 Hours

Abstract

Pharmacological inhibitors of glutathione synthesis and circulation, such as buthionine-sulfoximine, inhibit glutathione metabolism. These drugs decrease the aggressiveness of pancreatic cancer, inhibit tumor stem cell survival, and reduce chemotherapy resistance. Nevertheless, buthionine-sulfoximine also decreases the content of glutathione in normal cells, disrupts the balance between reactive oxygen species and glutathione, and eventually induces cell apoptosis. Pancreatic cancer is usually diagnosed at an advanced stage and has a poor prognosis. Consequently, the use of biomarkers to screen high-risk patients can be an effective method.

Keywords: Cancer stem cells; Chemoresistance; Pancreatic cancer; Pancreatic ductal adenocarcinoma; Redox

Core Tip: To reduce side effects, pharmacological inhibitors of glutathione synthesis and circulation, such as buthionine-sulfoximine and 6-aminonicotinamide, can be assessed by in vivo models of pancreatic cancer. Evaluating the impact of different organs on metabolic processes and the invasiveness of cancer stem cells may provide new avenues for therapeutics targeting tumor metabolism.