谷优优, 王珏磊, 陈宗南, 王肃, 刘晓智. 奥美拉唑及其S异构体诱发痛风急性发作的病例分析. 世界华人消化杂志 2022; 30(19): 845-849 [DOI: 10.11569/wcjd.v30.i19.845]
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质子泵是一类膜整合糖蛋白, 它可以逆浓度梯度转运氢离子跨膜, 胃型H+-K+-ATP酶负责是细胞腔的酸化, 主要位于胃黏膜的壁细胞内, 还存在于肾髓质和皮质集合管细胞.奥美拉唑及其S异构体诱发痛风性关节炎急性发作,其机制可能与其抑制肾脏H+-K+-ATP酶, 使尿酸排泄减少有关. 我们在临床上亦多次发现类似病例，进一步深入探讨其机理有临床指导价值