袁余懿, 刘与进, 范恒. Th17细胞及其相关细胞因子在IBD中研究新进展. 世界华人消化杂志 2021; 29(24): 1402-1409 [DOI: 10.11569/wcjd.v29.i24.1402]
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03740490
Submitted on:
January 19, 2022, 02:22
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在炎症性肠病(inflammatory bowel disease, IBD)的发生发展过程中, TH17细胞及其相关细胞因子发挥着促炎和抗炎的双重作用, TH17细胞本身及IL-17、IL-23发挥着促炎的作用, 而TH17细胞分泌的IL-22、IL-10发挥着保护作用, TH17细胞在炎症因子环境中, 具有很大的可塑性, IL-6、TGF-β、IL-12、IL-23、IL-21、IL-22等会参与的不同的调控机制, 进而影响TH17细胞相关的多种平衡, 为IBD中TH17细胞建立框架提供新思路
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03736031
Submitted on:
January 18, 2022, 01:30
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Scientific Quality:
The overall quality of the manuscript, based on the above-listed criteria, should be evaluated and classified according to the following five categories
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本文系统综述了Th17细胞及其相关细胞因子在IBD中研究新进展，结合目前的研究以IL-17、IL-23在IBD的致病因素以及IL-10和IL-22的保护因素具体展开，可见Th17细胞在调节IBD的炎症过程中起着关键作用，有大为广阔的研究前景，值得关注。