宋鑫, 王添贤, 朱小年, 谭盛葵. 肝细胞癌中CBX2的免疫和预后意义的综合分析. 世界华人消化杂志 2021; 29(19): 1118-1129 [DOI: 10.11569/wcjd.v29.i19.1118]
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October 20, 2021, 09:15
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CBX2的高表达与HCC患者的TNM分期和AFP具有相关性并且与HCC患者的预后不良相关. CBX2高表达与中性粒细胞、巨噬细胞和CD8+T细胞的浸润水平呈正相关; 我们确定了CBX2与10个免疫抑制因子和23个免疫刺激因子之间的关系. 基于这33个免疫调节剂, 我们建立了多基因风险预测模型, 得到的风险评分是一个独立的预后预测因子, 本文还构建了一个带有校准曲线的预测诺模图来预测个体的3年和5年生存概率. CBX2阳性表达是HCC患者的预后危险因素并且可能是HCC的潜在免疫治疗靶点，有一定临床指导意义.