Retrospective Study
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 7, 2015; 21(9): 2711-2718
Published online Mar 7, 2015. doi: 10.3748/wjg.v21.i9.2711
Neoadjuvant chemoradiotherapy followed by D2 gastrectomy in locally advanced gastric cancer
Mi Sun Kim, Joon Seok Lim, Woo Jin Hyung, Yong Chan Lee, Sun Young Rha, Ki Chang Keum, Woong Sub Koom
Mi Sun Kim, Ki Chang Keum, Woong Sub Koom, Department of Radiation Oncology, Yonsei University College of Medicine, Seoul 120-752, South Korea
Joon Seok Lim, Department of Radiology, Yonsei University College of Medicine, Seoul 120-752, South Korea
Woo Jin Hyung, Department of Surgery, Yonsei University College of Medicine, Seoul 120-752, South Korea
Yong Chan Lee, Department of Internal Medicine, Yonsei University College of Medicine, Seoul 120-752, South Korea
Sun Young Rha, Department of Medical Oncology, Yonsei University College of Medicine, Seoul 120-752, South Korea
Author contributions: Koom WS designed the study; Kim MS contributed to the study design, performed the statistical analysis, and wrote the manuscript; Lim JS, Hyung WJ, Lee YC, Rha SY and Keum KC performed the research and assisted in drafting the manuscript; all authors read and approved the final manuscript.
Ethics approval: The study was reviewed and approved by the Yonsei University Health System, Severance Hospital Institutional Review Board.
Informed consent: The study demonstrated minimal risk for included patients and received a waiver of informed consent from the Institutional Review Board.
Conflict-of-interest: All authors certify that no actual or potential conflict-of-interest in relation to this article exists.
Data sharing: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Woong Sub Koom, MD, Department of Radiation Oncology, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752, South Korea. mdgold@yuhs.ac
Telephone: +82-2-22288116 Fax: +82-2-3129033
Received: September 11, 2014
Peer-review started: September 12, 2014
First decision: October 29, 2014
Revised: November 19, 2014
Accepted: December 13, 2014
Article in press: December 16, 2014
Published online: March 7, 2015
Processing time: 178 Days and 19.5 Hours
Core Tip

Core tip: In locally advanced gastric cancer (LAGC), R0 resection is a well-established predictive factor. To achieve R0 resection, neoadjuvant approaches have been attempted. Studies of neoadjuvant chemotherapy followed by radical gastrectomy and D2 dissection have resulted in favorable outcomes and large studies of neoadjuvant chemotherapy are underway. Data on neoadjuvant chemoradiotherapy (NACRT) in LAGC are limited. This retrospective study was performed to investigate the efficacy of NACRT in LAGC. We found that NACRT increased the chance for an R0 resection and potentially enhanced survival in LAGC.