Brief Reports
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World J Gastroenterol. May 21, 2005; 11(19): 3002-3004
Published online May 21, 2005. doi: 10.3748/wjg.v11.i19.3002
Recurrent acute pancreatitis and its relative factors
Wei Zhang, Hong-Chao Shan, Yan Gu
Wei Zhang, Hong-Chao Shan, Yan Gu, Department of Surgery, Ninth Affiliated People’s Hospital, Shanghai Second Medical University, Shanghai 200011, China
Author contributions: All authors contributed equally to the work.
Correspondence to: Wei Zhang, Department of Surgery, Ninth Affiliated People’s Hospital, Shanghai Second Medical University, Shanghai 200011, China. weizh1518@ hotmail.com
Telephone: +86-21-53591134
Received: June 29, 2004
Revised: June 30, 2004
Accepted: August 5, 2004
Published online: May 21, 2005
Abstract

AIM: To evaluate the causes and the relative factors of recurrent acute pancreatitis.

METHODS: From 1997 to 2000, acute pancreatitis relapsed in 77 of 245 acute pancreatitis patients. By reviewing the clinical treatment results and the follow-up data, we analyzed the recurrent factors of acute pancreatitis using univariate analysis and multivariate analysis.

RESULTS: Of the 245 acute pancreatitis patients, 77 were patients with recurrent acute pancreatitis. Of them, 56 patients relapsed two times, 19 relapsed three times, each patient relapsed three and four times. Forty-seven patients relapsed in hospital and the other 30 patients relapsed after discharge. Eighteen patients relapsed in 1 year, eight relapsed in 1-3 years, and four relapsed after 3 years. There were 48 cases of biliary pancreatitis, 3 of alcohol pancreatitis, 5 of hyperlipidemia pancreatitis, 21 of idiopathic pancreatitis. Univariate analysis showed that the patients with local complications of pancreas, obstructive jaundice and hepatic function injury were easy to recur during the treatment period of acute pancreatitis (P = 0.022<0.05, P = 0.012<0.05 and P = 0.002<0.05, respectively). Multivariate analysis showed that there was no single factor related to recurrence. Of the 47 patients who had recurrence in hospital, 16 had recurrence in a fast period, 31 after refeeding.

CONCLUSION: Acute pancreatitis is easy to recur even during treatment. The factors such as changes of pancreas structure and uncontrolled systemic inflammatory reaction are responsible for the recurrence of acute pancreatitis. Early refeeding increases the recurrence of acute pancreatitis. Defining the etiology is essential for reducing the recurrence of acute pancreatitis.

Keywords: Acute pancreatitis; Relative factors