Effect of anti-tuberculosis therapy on liver function of pulmonary tuberculosis patients infected with hepatitis B virus

doi:10.3748/wjg.v11.i16.2518

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Apr 28, 2005 (publication date) through Nov 27, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Apr 28, 2005; 11(16): 2518-2521
Published online Apr 28, 2005. doi: 10.3748/wjg.v11.i16.2518

Effect of anti-tuberculosis therapy on liver function of pulmonary tuberculosis patients infected with hepatitis B virus

Lei Pan, Zhan-Sheng Jia, Lin Chen, En-Qing Fu, Guang-Yu Li

Lei Pan, Zhan-Sheng Jia, Guang-Yu Li, Center of Infectious Diseases, Tangdu Hospital, Fourth Military Medical University, Xi’an 710038, Shaanxi Province, China

Lin Chen, En-Qing Fu, Respiratory Department, Tangdu Hospital, Fourth Military Medical University, Xi’an 710038, Shaanxi Province, China

Author contributions: All authors contributed equally to the work.

Correspondence to: Lei Pan, PhD, Center of Infectious Diseases, Tangdu Hospital, Fourth Military Medical University, Xi’an 710038, Shaanxi Province, China. panlei0225@sina.com

Telephone: +86-29-83528137 Fax: +86-29-83537377

Received: February 11, 2004
Revised: February 12, 2004
Accepted: February 21, 2004
Published online: April 28, 2005

Abstract

AIM: To observe the effect of anti-tuberculosis therapy on liver function of pulmonary tuberculosis patients with hepatitis B virus (HBV) infection, and to compare the differences of liver function by two treatments of anti-tuberculosis.

METHODS: Forty-seven TB patients with HBV infection and 170 TB patients without HBV infection were divided into HPBE(S) and HLAMKO treatment groups. Liver function tests before and after the treatments were performed once in 2 wk or monthly, and their clinical manifestations were recorded.

RESULTS: The rate of hepatotoxicity occurred in 26 (59%) TB patients with HBV during anti-TB treatment, higher than that in 40 (24%) TB patients without HBV. Hepatotoxicity occurred in 66 out of 217 patients, and the incidence of liver dysfunction was 46.1% in HPBE(S) group, significantly higher than that in HLAMKO group (12.7%) (P<0.01).

CONCLUSION: TB patients with HBV should choose HLAMKO treatment because of fewer hepatotoxicity.

Keywords: Anti-tuberculosis; HBV