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958 items Read more >>
1
"Comment We would like to express our sincere appreciation to the Editorial Office and the entire team of the World Journal of ..."
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"Comment We would like to express our sincere appreciation to the Editorial Office and the entire team of the World Journal of Gastrointestinal Surgery for their professionalism, efficiency, and clear communication throughout the submission, peer-review, and publication process of our manuscript. We are grateful for the constructive feedback provided by the reviewers and for the timely and transparent editorial guidance, which significantly contributed to improving the quality and clarity of our work. It has been a pleasure to collaborate with a journal that maintains high scientific and editorial standards. We truly appreciate the opportunity to publish our research and look forward to future collaborations. "
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Bautista-Mondragón CA, Mijangos-Trejo AM, González-Chon O, Mondragón-Ratkovich P, Chávez-Tapia NC. Predictors of mortality and liver transplant requirement in patients with hepatitis A virus: A case series from Mexico. World J Gastrointest Surg 2026; 18(1): 112767
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"The experience with the publishing process was positive. The editorial team was professional, efficient, and responsive, providing ..."
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"The experience with the publishing process was positive. The editorial team was professional, efficient, and responsive, providing clear guidance at each stage of submission and revision. The peer-review process was rigorous yet fair, with the reviewer offering constructive comments that improved the quality, clarity, and scientific value of the manuscript. Overall, the process was well organized and supportive, making the collaboration with the journal both productive and rewarding. "
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Roganovic J, Vidovic A, Dordevic A. Late hepatotoxicity after treatment for childhood cancer. World J Hepatol 2026; 18(1): 113465
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"I am very satisfied with the entire publication process in the World Journal of Hepatology. The peer review was rigorous and ..."
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"I am very satisfied with the entire publication process in the World Journal of Hepatology. The peer review was rigorous and constructive, which significantly helped to improve the quality of our manuscript. The editorial team was efficient, professional, and responsive throughout. I appreciate the opportunity to publish our work in this high-quality open-access journal. "
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Yodoshi T. Whole-exome sequencing illuminates unexplained pediatric cholestatic liver disease. World J Hepatol 2026; 18(1): 115037
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"I would like to sincerely thank the assistant editor, editor, editorial director, editor-in-chief, peer reviewers, language editor, ..."
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"I would like to sincerely thank the assistant editor, editor, editorial director, editor-in-chief, peer reviewers, language editor, and production editor for their professionalism, efficiency, and constructive support throughout the entire publication process. The communication was clear and timely, the review process was thorough and fair, and the editorial guidance significantly contributed to improving the quality and clarity of the manuscript. The overall experience was smooth and well-organized, reflecting a high standard of editorial management. I truly appreciate the efforts of the whole editorial team and am very satisfied with the publication process. I would be happy to consider submitting future work to the journal. "
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Boutos P, Karakasi KE, Katsanos G, Antoniadis N, Kofinas A, Tsoulfas G. Harnessing artificial intelligence in gastroenterology and hepatology: Current applications and future perspectives. World J Hepatol 2026; 18(1): 111902
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"We would like to express our sincere gratitude to the BPG Group for granting us the opportunity to participate in this project. ..."
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"We would like to express our sincere gratitude to the BPG Group for granting us the opportunity to participate in this project. Throughout the process of paper publication, we have gained access to the most up-to-date information in this field, which has also provided valuable insights for our own research. We would like to extend our thanks once again. "
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Cui X, Yin BQ, Chen L. Remote telerehabilitation for frailty management in liver transplant candidates: A feasible yet underutilized strategy. World J Hepatol 2026; 18(1): 114880
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"The publication process with F6 Publishing was exceptionally smooth and efficient from start to finish. Communication was clear and ..."
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"The publication process with F6 Publishing was exceptionally smooth and efficient from start to finish. Communication was clear and timely, and every step of the workflow was handled in a professional and well-organized manner. The editorial and production teams were highly supportive, making the overall experience both pleasant and stress-free. Overall, it was a very positive, reliable, and truly wonderful publishing experience. "
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Mukundan A, Gupta D, Karmakar R, Wang HC. Endoscopic resection: A novel approach for treating oesophageal gastrointestinal stromal tumours. World J Gastrointest Endosc 2025; 17(6): 107088
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"The publication process with F6 Publishing was exceptionally smooth and efficient from start to finish. Communication was clear and ..."
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"The publication process with F6 Publishing was exceptionally smooth and efficient from start to finish. Communication was clear and timely, and every step of the workflow was handled in a professional and well-organized manner. The editorial and production teams were highly supportive, making the overall experience both pleasant and stress-free. Overall, it was a very positive, reliable, and truly wonderful publishing experience. "
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Mukundan A, Gupta D, Karmakar R, Wang HC. Transforming pediatric imaging: The role of four-dimensional flow magnetic resonance imaging in quantifying mesenteric blood flow. World J Radiol 2025; 17(6): 106582
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"The publication process with F6 Publishing was exceptionally smooth and efficient from start to finish. Communication was clear and ..."
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"The publication process with F6 Publishing was exceptionally smooth and efficient from start to finish. Communication was clear and timely, and every step of the workflow was handled in a professional and well-organized manner. The editorial and production teams were highly supportive, making the overall experience both pleasant and stress-free. Overall, it was a very positive, reliable, and truly wonderful publishing experience. "
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Mukundan A, Gupta D, Karmakar R, Wang HC. Novel approach to risk stratification: Integrating waist-hip ratio for predicting advanced colorectal neoplasia. World J Clin Oncol 2025; 16(10): 109843
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"The publication process with F6 Publishing was exceptionally smooth and efficient from start to finish. Communication was clear and ..."
[Read more]
"The publication process with F6 Publishing was exceptionally smooth and efficient from start to finish. Communication was clear and timely, and every step of the workflow was handled in a professional and well-organized manner. The editorial and production teams were highly supportive, making the overall experience both pleasant and stress-free. Overall, it was a very positive, reliable, and truly wonderful publishing experience. "
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Karmakar R, Gade P, Wang HC, Mukundan A. Very early recurrence in pancreatic cancer: Redefining prognostic markers and surveillance strategies. World J Gastrointest Surg 2026; 18(1): 114574
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"The Journal gives the best publishing experience with absolute transparency in the porcesses and timelines. The design of the ..."
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"The Journal gives the best publishing experience with absolute transparency in the porcesses and timelines. The design of the manuscript and the pdf has come out very well. We would again like to thank all editors in the group for the fabulous efforts. I would like to keep comming back to WJCC for publication. "
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Mahanty PR, Sen B, Anand R, Nag DS, Pahadi N, Lodh D, Upadhyaya T. Sphenopalatine ganglion block for postdural puncture headache: A review of current evidence. World J Clin Cases 2026; 14(3): 114521
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"This is a valuiable journal . The response time from reviewers was fantastic and the whole submission process was very clear and ..."
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"This is a valuiable journal . The response time from reviewers was fantastic and the whole submission process was very clear and intuitive.The editing was very thorough, and the article was published very quickly. The journal has a significant impact on international scientific society, and I would be happy to publish another article as soon as possible "
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Tringali A, Caiazzo A. Role of endoscopic ultrasound in the treatment of pancreatic neuroendocrine tumors: Lights and shadows of endoscopic ultrasound-guided radiofrequency ablation. World J Gastrointest Endosc 2026; 18(1): 113617
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"All the process for manuscript submission and publication are quite smooth, standard and prompt, by these factors ensuring the high ..."
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"All the process for manuscript submission and publication are quite smooth, standard and prompt, by these factors ensuring the high qulaity and speed for knowledge transmitting. For this editorial article, we enjoyed the expert service both by editors and reviewers, hence the hotspot in this work can effecively be presented to all of the journal's readers and the specific scientists. "
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He ZX, Wang J, Yang JS. Expanding the applications of artificial intelligence in emergency radiology: Advancing precision medicine and resource efficiency. World J Radiol 2026; 18(1): 117814
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"The journal’s reputation for excellence is clearly reflected in your team’s dedication, and I truly appreciate the effort put into ..."
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"The journal’s reputation for excellence is clearly reflected in your team’s dedication, and I truly appreciate the effort put into ensuring a smooth and successful publication. Thank you for your hard work and support—it has been a pleasure working with you. I look forward to future opportunities to contribute to your esteemed journal "
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Wu CM, Zhu WJ, Chen X, Liu M, Feng Y, Wang M. Risk factors for enteral nutrition intolerance and its impact on prognosis in patients with severe acute pancreatitis. World J Gastrointest Surg 2026; 18(1): 112334
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"Overall, we are pleased that our manuscript has been published in this respected journal. The peer-review process was rapid, although ..."
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"Overall, we are pleased that our manuscript has been published in this respected journal. The peer-review process was rapid, although somewhat unusual compared with our previous experiences. After acceptance, the manuscript proofs moved to in press status; however, more than three months passed without any information regarding the final publication date. Overall, our experience with the editorial team was positive, but we found the journal’s online platform somewhat confusing. In particular, during the revision period, a countdown timer was displayed that did not correspond to the official deadline that had been assigned. "
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Quiroz-Reyes AG, Delgado-Gonzalez P, Islas JF, Loaiza-Gutierrez VL, Santoyo-Suarez MG, Garcia-Loredo JA, Gonzalez-Villarreal CA, Ramirez-Fernandez F, Garza-Treviño EN. Tumor microenvironment-driven microRNA dysregulation: Key interactions in colorectal cancer progression. World J Gastrointest Oncol 2026; 18(1): 113553
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"Overall, we are pleased that our manuscript has been published in this respected journal. However, the peer-review process was unusual ..."
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"Overall, we are pleased that our manuscript has been published in this respected journal. However, the peer-review process was unusual compared to our previous experiences. Following the acceptance of our manuscript, we were expecting to receive the proofs; instead, we were asked to respond to a second round of reviewer comments. Although we found it unexpected to address additional reviewer queries after receiving the acceptance letter, we nevertheless provided detailed responses, as we believed these revisions would further strengthen the manuscript. This situation may have arisen due to a miscommunication between the editor and the reviewers. Additionally, the online submission system could benefit from improvements to enhance its user-friendliness. "
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Taskiran I, Orenay-Boyacioglu S, Boyacioglu O, Erdogdu IH, Culhaci N, Meteoglu I. DNA polymerase epsilon-mutant colorectal cancers: Insights into non-exonuclease domain mutation variants, microsatellite instability status, and co-mutation profiles. World J Gastroenterol 2025; 31(44): 112524
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"The reviewers provided much more valuable comments to our manuscript, and the review time was short. The Editor reviewing manuscript ..."
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"The reviewers provided much more valuable comments to our manuscript, and the review time was short. The Editor reviewing manuscript was very carefully, and gave our more opportunity to revise the manuscript. But the publication processes was too long。 The submission was complex, especially in uploading attachment materials, it is complex and tedious. "
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Tang Q, Wu Y, Chen L, Jia QY, Tang FQ. Ferritin as a novel predictive index for nasopharyngeal carcinoma survival and therapeutic efficacy of different chemotherapy regimens. World J Clin Oncol 2026; 17(1): 114012
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"We are highly satisfied with the overall submission process, reviewers’ comments, manuscript editing, submission system, and the speed ..."
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"We are highly satisfied with the overall submission process, reviewers’ comments, manuscript editing, submission system, and the speed of review. We look forward to the growing influence of your journal. We also hope to continue submitting higher quality research to your publication in the future. Thank you for your hard work and the dedicated efforts of the entire editorial team. "
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Jia ZD, Zhang CY, Liang SZ, Li HL. Primary splenic histiocytic sarcoma: A case report and review of literature. World J Clin Cases 2026; 14(3): 116125
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"The editorial and peer-review process was professional, transparent, and well-structured. The journal maintained a fair and balanced ..."
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"The editorial and peer-review process was professional, transparent, and well-structured. The journal maintained a fair and balanced approach, thoughtfully weighing both the authors’ contributions and the reviewers’ evaluations throughout the decision-making process. Reviewers provided constructive feedback that significantly improved the clarity and scientific rigor of the manuscript. Additionally, the editorial team’s practice of making decisions based on thorough and in-depth evaluations is highly commendable. Overall, the submission and publication workflow was efficient, rigorous, and highly satisfactory. "
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Tomsuk Ö. Harnessing CD146-positive mesenchymal stromal cells for precision therapy in acute respiratory distress syndrome. World J Stem Cells 2026; 18(1): 114825
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"We appreciate the efforts of the editorial office, reviewers, and production team for their professionalism and efficiency throughout ..."
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"We appreciate the efforts of the editorial office, reviewers, and production team for their professionalism and efficiency throughout the submission, revision, and publication process. The communication was timely, and the language editing and production workflow were well organized. Thank you for the opportunity to publish our work in the World Journal of Gastroenterology. "
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Chiu YC, Chang WC, Chiu YC. Early catheter-directed portal vein thrombolysis in myeloproliferative disorder-related diffuse mesenteric venous ischemia: A case report. World J Gastroenterol 2026; 32(4): 114906
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"Excellent journal and managing team. Very efficient handling and processing. All in all a very smooth and effortlessly process. ..."
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"Excellent journal and managing team. Very efficient handling and processing. All in all a very smooth and effortlessly process. Hopefully will have many more publications in this very reputable journal. I hope the journal continues to achieve more success and the same be reflected in the ever improving journal metrics. Hope to contribute in all ways possible. "
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Brar AS, Khanna T, Sohal A, Hatwal J, Sharma V, Singh C, Batta A, Chandra P, Mohan B. Metabolic dysfunction-associated steatotic liver disease and heart failure with preserved ejection fraction: A state-of-the-art review. World J Cardiol 2026; 18(1): 111954
20586 items Read more >>
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"Please explain in more detail the mechanism of carcinogenesis caused by bile reflux into the esophagus. Author write Bile acids can ..."
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"Please explain in more detail the mechanism of carcinogenesis caused by bile reflux into the esophagus. Author write Bile acids can act through specific signalling pathways, activating nuclear farnesoid X receptor and plasma-membrane-bound G protein-coupled bile acid receptors, and also likely through the interaction between these receptors. The coupling of G protein-coupled bile acid receptor to the stimulatory protein Gs leads to activation of adenylate cyclase, intracellular cAMP accumulation and protein kinase A activation, directly impacting on smooth muscle contractile activity.
Also, the author's theory of how bile reflux reduces esophageal motility is a new and interesting one. I would like to see more detailed research into esophageal motility beyond the 24-hour pH meter.
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Gadelha KKL, Santos AA, Correia-de-Sá P, Magalhães PJC, da Silva MTB. Can bile salts affect the contractile oesophageal activity associated with gastroesophageal reflux disease? World J Gastroenterol 2026; 32(4): 114560
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"The article presents a coherent and well‑structured argument by explaining why indocyanine green (ICG) fluorescence has become an ..."
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"The article presents a coherent and well‑structured argument by explaining why indocyanine green (ICG) fluorescence has become an essential tool in hepatocellular carcinoma surgery and supporting this with evidence from systematic reviews and clinical studies. It logically organizes the diverse applications of ICG—segmental mapping, detection of superficial lesions, thermal ablation guidance, and tumor‑biology assessment—showing how each technique addresses specific surgical limitations. The discussion consistently links fluorescence patterns to pathological features and clinical decision‑making, reinforcing the article’s central claim that ICG enhances precision, safety, and oncologic outcomes in minimally invasive liver surgery."
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Piccolo G, Barabino M, Benuzzi L, Formisano G, Bianchi PP. Clinical applications of indocyanine green fluorescence for the treatment of hepatocellular carcinoma. World J Gastrointest Oncol 2026; 18(1): 114339
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"The article maintains clear logical flow by presenting a rare SMARCB1‑deficient pancreatic rhabdoid carcinoma case and linking the ..."
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"The article maintains clear logical flow by presenting a rare SMARCB1‑deficient pancreatic rhabdoid carcinoma case and linking the unusual initial presentation—spontaneous splenic rupture—to the tumor’s aggressive biology. Its diagnostic reasoning is coherent, moving from clinical findings to imaging, pathology, and molecular profiling that distinctly separate the ductal adenocarcinoma and rhabdoid components. The discussion logically integrates existing literature to highlight the rarity, poor prognosis, and potential benefit of aggressive multimodal therapy, underscoring the need for targeted approaches in this molecular subtype."
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Yao WQ, Ma XY, Wang GH. Clinicopathologic features of SMARCB1/INI1-deficient pancreatic undifferentiated rhabdoid carcinoma: A case report and review of literature. World J Gastrointest Oncol 2026; 18(1): 114021
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"The article demonstrates strong logical coherence by clearly establishing the clinical gap in evidence for treating esophageal cancer ..."
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"The article demonstrates strong logical coherence by clearly establishing the clinical gap in evidence for treating esophageal cancer patients with liver metastases and justifying the need to compare chemotherapy alone with chemoimmunotherapy. Its methodology is rigorous and transparent, using well‑defined inclusion criteria, detailed baseline characteristics, and standardized outcome measures such as RECIST, overall survival, and progression‑free survival. The conclusions logically follow from the data, showing that adding immune checkpoint inhibitors significantly improves survival and response rates without increasing severe toxicity, and the study further strengthens its argument by identifying independent prognostic factors through multivariate Cox regression analysis."
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Dai EH, Que SH, Xu H, Zhong GQ, Zhang Z, Liang X, Zhai SW, Li YT, Wang JJ, Feng W. Efficacy and safety of immune checkpoint inhibitors plus chemotherapy in esophageal cancer patients with liver metastases. World J Gastrointest Oncol 2026; 18(1): 113440
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"The study presents a logically coherent argument by clearly identifying the clinical gap in evidence for nivolumab‑based chemotherapy ..."
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"The study presents a logically coherent argument by clearly identifying the clinical gap in evidence for nivolumab‑based chemotherapy in advanced gastric cancer with massive ascites and justifying the need for retrospective evaluation. Its methodology is well‑structured, using clearly defined ascites‑burden groups and standardized clinical criteria to ensure meaningful comparisons of outcomes and safety profiles. The conclusions follow naturally from the data, showing that although prognosis remains poor in the high‑ascites group, nivolumab plus chemotherapy provides measurable ascites improvement and acceptable toxicity, supporting its potential therapeutic value in this challenging population."
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Matsumoto T, Sugimoto S, Omori R, Makiyama C, Nakasya A, Nagai H, Yasui H, Higashi R, Sasamoto A, Satake H. Efficacy and safety of nivolumab plus chemotherapy in patients with advanced gastric cancer with massive ascites. World J Gastrointest Oncol 2026; 18(1): 112944
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"The document presents a clear, logical structure with well‑labeled sections and concise summaries that guide the reader through the ..."
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"The document presents a clear, logical structure with well‑labeled sections and concise summaries that guide the reader through the study’s objectives and findings. The methods and results are supported by detailed experimental design and high‑quality figures and tables, which enhance reproducibility and data transparency. The discussion highlights clinical relevance and practical implications, effectively linking mechanistic insights to potential therapeutic strategies."
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Vescio F, Curcio S, Aquila I, Ammendola M, Tarallo AP. Right patient approach to experimental stromal cell therapies for gastrointestinal tumors. World J Gastrointest Oncol 2026; 18(1): 112630
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"Intraductal papillary mucinous neoplasms (IPMN) are clinically important precancerous conditions of the pancreas. Their accurate ..."
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"Intraductal papillary mucinous neoplasms (IPMN) are clinically important precancerous conditions of the pancreas. Their accurate diagnosis requires a combination of imaging and endoscopic techniques. Pancreatoscopy enables direct visualization of the pancreatic duct, targeted biopsies, and the definition of disease boundaries. Existing data support the view that pancreatoscopy is a satisfactory and promising method for determining which patients with IPMN should undergo surgery, as well as the extent of resection for each patient. However, excessive enthusiasm should not prevail. The method is not widely applied; learning requires a dedicated endoscope and a sufficient number of patients per year to maintain and further increase experience, which is a very important factor. For the widespread acceptance and adoption of the method, it is necessary to conduct prospective, very well-designed multicenter studies aiming to precisely determine many parameters e.g. its diagnostic contribution and accuracy, which patients should undergo the examination, what is the impact on therapeutic decisions, what is the cost-benefit ratio and finally to determine whether it improves the survival and/or quality of life of patients. Based on the above observations, pancreatoscopy should be decided on a case-by-case basis and performed in specialized centers."
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Abusharar M, Barritt C, Mavroeidis VK, Aroori S. Role of pancreatoscopy in the management of suspected and confirmed intraductal papillary mucinous neoplasm of the pancreas. World J Gastroenterol 2026; 32(4): 112635
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"The paper is highly informative and comprehensive. The authors have gathered and synthesized the most significant and relevant data ..."
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"The paper is highly informative and comprehensive. The authors have gathered and synthesized the most significant and relevant data from the literature, presenting it in a clear and well-structured manner. The review provides valuable insights into the topic, highlights key mechanisms and clinical implications, and offers a solid foundation for future research and practical applications."
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Singh B, Singh H, Kaur S, Singh B. Preclinical pharmacology studies of zingerone with special reference to potential therapeutic applications. World J Immunol 2026; 16(1): 111511
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"The editorial appropriately highlights that the target article opens a new avenue for potential therapeutic strategies in Parkinson’s ..."
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"The editorial appropriately highlights that the target article opens a new avenue for potential therapeutic strategies in Parkinson’s disease and points out the lack of comprehensive studies to fully elucidate the underlying mechanisms. It also outlines future research directions. Overall, the editorial adds value to the target manuscript by providing complementary discussion and contextualization."
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Chen YX, Sun NQ, Mo SJ. Rhapontin activating nuclear factor erythroid 2-related factor 2 to ameliorate Parkinson’s disease-associated gastrointestinal dysfunction. World J Gastroenterol 2026; 32(4): 114468
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"The work is a readable, visually clear review that reframes fatty liver through choline metabolism and mitochondrial stress, with ..."
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"The work is a readable, visually clear review that reframes fatty liver through choline metabolism and mitochondrial stress, with solid editorial transparency. Concise upgrades—documented search/selection methods, figure/table evidence anchoring, explicit evidence‑tier labeling with effect sizes, and a short limitations/certainty note—would materially improve objectivity, credibility, and practical value for hepatology and metabolism audiences. The article is transparent on provenance, timelines, and authorship; it also includes a conflict‑of‑interest declaration. These are positives for editorial/ethical standards. For maximal clarity to non‑specialists, consider adding a one‑line ethics note that no new human/animal data were generated and that the work synthesizes published evidence only.
Methodologically, the piece reads as a narrative review. To support quality tracking and reproducibility, please add a concise 'search strategy and selection' box containing the following information: databases used, the exact date of the last search, key terms, language limits, inclusion/exclusion criteria and dual-reviewer screening/extraction. This would substantiate the statement of a comprehensive survey and help readers to assess selection bias.
The figures and tables are clear and helpful. Legends could be strengthened by stating whether panels are conceptual or data-derived, defining all abbreviations at first use, citing the primary sources that support each panel and adding n/assay details when values are quoted. Providing a single, consolidated evidence table per claim (model, dose/exposure, effect size/direction, study type and citation) would further aid readers.
The interpretation is generally cautious, but the evidence tier should be labelled consistently (in vitro vs. animal vs. human) and comparative claims (citicoline vs. α-GPC; LA/ethanol as 'mitochondrial toxins') should be anchored to primary studies with effect directions and context. It is important to explicitly note when human data are pilot/underpowered. A brief paragraph explaining why quantitative synthesis was not feasible (due to heterogeneity of models/endpoints) and a graded certainty statement for each major conclusion would prevent 'vote-counting'.
The biostatistics and data availability could be improved. Where numerical differences are cited in tables or text (e.g. '2.6-fold increase in plasma choline' or 'up to 30% reduction in triglycerides in preclinical models'), include the study design, sample size, comparator and 95% confidence intervals (CIs) where available. Consider including a small supplementary file with raw or minimally processed values from the cited studies."
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Mercola J. Fatty liver reexamined choline and mitochondrial toxin amelioration. World J Biol Chem 2025; 16(4): 111831
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"The work is transparent about its provenance, timelines and author contributions. It also discloses a conflict of interest relating ..."
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"The work is transparent about its provenance, timelines and author contributions. It also discloses a conflict of interest relating to the author's role as company founder and their involvement in product development related to C15:0.
This review is a readable and visually clear synthesis of C15:0 mechanisms with good editorial transparency and a useful mechanistic overview. A few concise upgrades, such as search/methods transparency, evidence-tier labelling, quantitative anchors for key effects and explicit limitations, would materially improve objectivity, credibility and practical value for translational audiences.
As a narrative review, the article summarises the proposed mechanistic actions of pentadecanoic acid (C15:0), including partial PPAR-α/δ agonism, AMPK activation, mTOR suppression, HDAC6 inhibition and modulation of the anti-inflammatory pathway, and provides helpful pathway schematics and a BioMAP® heatmap.
Regarding theinterpretation, the figures are legible and informative, but several mechanistic statements are presented as causal when much of the evidence is preclinical or platform-based (e.g. BioMAP® panels and cell assays). Please anchor each mechanism to specific primary studies and consistently label the evidence tier (in vitro, in vivo or human observational). Where the review draws parallels between the effects of C15:0 and metformin/rapamycin, cite comparative, peer-reviewed experiments and quantify the direction of the effects to avoid 'phenotypic mirroring' based on analogy alone. If you are relying on cell-system phenotyping reports, you should specify the doses, reference compounds and cytotoxicity thresholds, and discuss the limits of generalisability.
Figures/tables: Expand figure legends to state whether values are empirical (with n, assay and statistics) or conceptual and include scale and statistical annotations where applicable.
Biostatistics and certainty: Although a formal meta-analysis is not expected, readers would benefit from the reporting of representative effect sizes (e.g. EC₅₀ ranges or fold changes with 95% confidence intervals) for key targets, alongside a short paragraph explaining why quantitative synthesis across studies is not feasible (e.g. heterogeneity of models and endpoints). Providing a graded certainty statement (e.g. 'moderate' for PPAR-α/δ binding; 'low'/'very low' for clinical efficacy) would prevent over-extrapolation.
Providing a neutral summary that acknowledges the limited number of human prospective trials of C15:0 for metabolic or longevity endpoints would align enthusiasm with the current evidence base."
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Mercola J. Molecular and cellular mechanisms of pentadecanoic acid. World J Biol Chem 2025; 16(4): 111258
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"The manuscript is fully transparent in terms of its editorial process and declares any conflicts of interest and compliance with the ..."
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"The manuscript is fully transparent in terms of its editorial process and declares any conflicts of interest and compliance with the PRISMA 2009 guidelines. This is a timely and relevant systematic review of the gut microbiome and chemotherapy-induced cardiotoxicity, with good editorial transparency and a useful PRISMA framework. The reference list is current and thematically appropriate. These factors positively contribute to ethical and reporting standards, making provenance clear to readers. Consider adding a brief statement confirming that no new human or animal data were collected, and that only published or registry data were used, to close the ethics loop for non-specialists.
As a systematic review, the methods section would benefit from providing compact yet reproducible details. While you do include a PRISMA flow diagram, the main text should also specify the databases searched (with the exact date of the last search), the full search strings, any language restrictions, the inclusion/exclusion criteria, and the tool used for the risk-of-bias assessment (e.g. ROBINS-I, RoB2 or SYRCLE). A short table summarising study designs, sample sizes, chemotherapy classes, cardiotoxicity definitions and microbiome endpoints would help readers to understand the heterogeneity.
Regarding the results and interpretation, the narrative rightly identifies microbial metabolites and gut–heart crosstalk as candidate pathways. Anchoring these mechanisms to recent overviews of microbiome–chemotherapy interactions and core mechanistic reviews would improve the balance and timeliness of the review.
The figures and tables are adequate (PRISMA and one data table are included in the journal assets). The legends could be strengthened by declaring whether each figure is conceptual or data-derived, defining all abbreviations at first use and adding a per-study evidence table (study; cancer/chemo; cardiotoxicity endpoint; microbiome assay; key finding; risk of bias).
Readers will expect some appraisal of effect direction/size where feasible (e.g., HRs/ORs for cardiotoxicity associations or standardised mean differences for metabolite levels), even if a meta-analysis is not possible. Including a concise 'why no pooling' paragraph (explaining heterogeneity in definitions, assays and timepoints) and a GRADE-style certainty statement for each major conclusion (very low, low or moderate) would prevent 'vote-counting' impressions and increase the utility of the review's conclusions."
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Abdulaal R, Afara I, Harajli A, Al Mashtoub E, Tarchichi A, Hassan K, Afara A, Abou Fakher J, Salhab S, Fassih I, Tlais M. Gut microbiome and chemotherapy-induced cardiotoxicity: A systematic review of evidence and emerging therapies. World J Biol Chem 2025; 16(4): 112221
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"This study is clearly presented, transparent and visually clear that would be notably strengthened by fuller methodological rigor ..."
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"This study is clearly presented, transparent and visually clear that would be notably strengthened by fuller methodological rigor (randomization/blinding/power, assay standards), richer statistics and data sharing, and a more circumspect translational framing. These concise additions would enhance objectivity, credibility, and scientific utility for the community. The references are appropriate and full editorial metadata are provided. Funding and conflict-of-interest statements are also included, along with details of compliance with the ARRIVE guidelines, animal ethics approval, and CC BY-NC 4.0 licensing. This transparency aligns with the journal’s quality policy and is a strength of the article. It would be beneficial to add a brief ethics note to clarify humane endpoints and analgesia during tail transection for readers who are not specialists.
The methods section would benefit from a more concise description to support reproducibility. Report the sex and exact age range/ageing criterion of the mice, their housing conditions, and the full rationale for the therapeutic BoNT formulation (serotype, units/kg, injection site/volume, and timeline to assay). Given the focus on coagulation, full protocols for platelet aggregation should be added (e.g. agonist, concentration, light transmission vs microscopy) and standard plasma assays (PT/INR, aPTT, fibrinogen) should be included to triangulate the tail bleeding endpoint. These additions would make the work easier to replicate and compare with prior haemostasis literature.
The results are clear and the figures are legible, but several quality improvements would be helpful. For Figures 1–3, it would include n per group on the plots and show all data points with mean ± SD/SEM. State the exact statistical tests used (normality testing, two-sidedness and corrections for multiplicity) and report effect sizes with 95% CIs. In the legends, indicate how many independent experiments/animals the images are representative of, and add scale bars and magnifications. Where possible, provide raw or minimally processed data (e.g. bleeding times, body weights, aggregation percentages) in a supplementary file to meet current data availability expectations.
Interpretation should be cautious to avoid overreach. While a single dose in ageing mice suggests a pro-coagulant/anti-haemorrhagic effect, the systemic or off-target neuromuscular actions of BoNT could confound behaviour during the assay. Please discuss the potential mechanisms (e.g. platelet number/function, coagulation cascade, or local vasomotor effects) and outline experiments that would clarify them (e.g. complete blood count/platelet counts, thromboelastography, ROTEM, or endothelial markers). Translational claims (e.g. use in trauma/surgery) should be limited until dose–response, time-course, safety (toxicity, motor impairment) and reversibility are established, and the findings should be considered in the context of contemporary BoNT pharmacology/safety reviews."
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Ravichandran S, Joseph JHM, Sellathamby S, Kandasamy M. Intramuscular injection of therapeutic botulinum toxin facilitates blood coagulation in experimental aging mice. World J Biol Chem 2025; 16(4): 112376
14
"This minireview is a useful and well-illustrated synthesis of the IFN-γ–ISG axis in glioblastoma, with good editorial transparency, ..."
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"This minireview is a useful and well-illustrated synthesis of the IFN-γ–ISG axis in glioblastoma, with good editorial transparency, alongside transparent metadata on provenance.
The piece could be elevated to a best-practice minireview while preserving its brevity and readability by adding a concise methods note for literature selection, tightening causal language, enriching legends/references to anchor mechanisms, and stating limitations explicitly.
Regarding the results and their interpretation, the mechanistic thread is accurate and accessible.
The figures are clear and didactic. However, a compact summary table cross-linking each ISG to its function, model/evidence, clinical signal (if applicable) and approximate level of evidence would help translational readers further.
The language quality is high, and minor spacing artefacts appear to be HTML rendering issues that will not affect the PDF. A short, explicit 'Limitations and outlook' paragraph acknowledging the non-systematic approach, potential selection bias and the need for stratified clinical validation of IFN-γ/ISG signatures in standard-of-care and immunotherapy contexts would round off the manuscript's critical appraisal. "
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Oropeza-Martínez E, Palacios Serrato EG, Zamora-Salas SX, Lira-Rodríguez NA, López-Mignon SH, Martinez-Benitez MB, Tecalco-Cruz AC. Interferon-gamma signaling pathway: Modulation of key genes in the progression of glioblastoma. World J Biol Chem 2025; 16(4): 112768
15
"This is a well-constructed and transparent preclinical systematic review that adheres to the PRISMA reporting guidelines. It clearly ..."
[Read more]
"This is a well-constructed and transparent preclinical systematic review that adheres to the PRISMA reporting guidelines. It clearly states its murine-only scope and documents multi-database searching and the SYRCLE risk-of-bias assessment. These elements support the objectivity and credibility of the review for readers appraising the animal evidence. The ethics and availability are handled appropriately, matching the journal's standards for this type of article.
The synthesis is organised in a reader-friendly way and remains faithful to the preclinical findings without making claims that extend beyond the scope of the human literature. This approach strengthens the balance and credibility of the manuscript. Visual reporting is a strong point: the PRISMA flow and SYRCLE bias graphics meaningfully enhance transparency.
A practical note on presentation quality: in the HTML view, some figure panels appear slightly compressed, low-resolution or distorted, whereas the 'Full size/download' versions are clear and legible. Readers will benefit from accessing the high-resolution links.
Statistically, the manuscript does not overstate certainty, and the narrative is consistent and cautious in relation to the evidence base. References are recent and field-relevant, and the prose is clear and concise. As caveats intrinsic to the scope of the review, the preclinical-only inclusion is appropriate, but it necessarily limits direct clinical inference. As the review itself documents, some domains in the included studies show 'unclear' risk due to reporting (e.g. allocation concealment/blinding), which is a common feature of animal research and is displayed properly in the SYRCLE plots."
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Ochoa KL, Heredia AG, Piedra CC, Arias RJ, Ortiz BJ, Dominguez-Gortaire JA. Association between Alzheimer's disease and Porphyromonas gingivalis products in murine models: A systematic review. World J Biol Chem 2025; 16(4): 111156
16
"This study uses the C. elegans model to examine how the endoplasmic reticulum (ER) stress inducer dithiothreitol (DTT) affects neuronal ..."
[Read more]
"This study uses the C. elegans model to examine how the endoplasmic reticulum (ER) stress inducer dithiothreitol (DTT) affects neuronal function and behaviour, with a particular focus on the activation of the unfolded protein response and readouts relevant to neurodegeneration. From an ethics and transparency perspective, the article adheres to publishing standards and provides readers with adequate procedural clarity.
Methodologically, the experimental framework relies on familiar and reproducible tools in the field of C. elegans research: graded DTT exposure, molecular markers of ER stress and locomotor/behavioural assays. The figures and captions document the key elements of the approach, providing fellow researchers with sufficient operational detail to comprehend the setup and replicate the primary measurements. Overall, the methods are effective for the stated aims and fall squarely within established practice for probing ER-stress-linked phenotypes in C. elegans.
In terms of results and credibility, the study's findings are directionally consistent and biologically plausible. The work is therefore coherent mechanistically in relation to the broader field, where both canonical ER effects (misfolded protein load, UPR engagement) and additional cellular pathways influenced by DTT have been described.
The figures and tables are informative and useful, but the resolution quality is poor and some of them are distorted. The set of figures covers the core narrative, and the layout facilitates quick appraisal of both effect direction and relative magnitude.
From a biostatistics perspective, the article provides transparent summary statistics and specifies the inferential test in the legend. This is an appropriate approach for these endpoints and sample sizes in a discovery-oriented worm study. While the work is not a quantitative synthesis, the statistical approach is appropriate for the scope of the study and does not overstate certainty.
In terms of references and positioning, the rationale of the manuscript is consistent with the existing literature on redox-mediated folding stress and UPR-linked neurobiology in experimental systems. The conceptual placement is therefore sound and timely, given recent mechanistic reports on how DTT influences cellular metabolism and stress pathways in C. elegans and mammalian cells [wjgnet.com; elifesciences.org; link.springer.com].
The language and presentation in the main text are generally clear and concise; the rationale, design and readouts are communicated effectively to an audience of molecular neurobiologists and stress biologists. Ancillary materials hosted on the publisher’s platform (e.g. process pages) contain minor typographical errors in the summaries, but the scientific narrative in the article itself is easy to read.
As for caveats intrinsic to the scope of the study, it reflects the strengths and boundaries of the chosen model and perturbagen. The C. elegans system provides accessible neurobehavioural phenotyping and stress signalling, and DTT is a recognised ER stress proxy. Readers will naturally contextualise the findings, knowing that some DTT effects can extend beyond the ER and that invertebrate observations are a first step in the process of translation. Within this context, the article successfully links DTT-evoked ER stress to functional outcomes in vivo in a concise and accessible manner."
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Raj G, Kumar M, Shreya S, Bhardwaj S, Priya R, Mangalhara KC, Jain BP. Dithiothreitol induced endoplasmic reticulum stress and its role in neurodegeneration in Caenorhabditis elegans. World J Biol Chem 2025; 16(4): 111110
17
"This minireview provides a clear, well-structured and up-to-date overview of pancreatic macrophages in obesity and their role in ..."
[Read more]
"This minireview provides a clear, well-structured and up-to-date overview of pancreatic macrophages in obesity and their role in metabolic dysregulation. From an ethics and transparency standpoint, the article meets the publishing standards expected of this type of article.
Methodologically, the inclusion of a 'Methodology of data collection' section is uncommon but welcome for a narrative review, as it specifies the databases and key terms used, as well as the time period considered.
With respect to the results and their interpretation, the synthesis is both internally consistent and biologically coherent. The manuscript effectively links macrophage recruitment and polarisation, immunometabolic signalling nodes, and inter-organ communication to demonstrate how shifts in the innate immune system can influence β-cell stress, fibrosis, and endocrine dysfunction. The translational thread, which highlights potential checkpoints and cellular programmes of interest, is presented in a manner that remains faithful to the underlying evidence base while maintaining a clear focus on clinical relevance. Where statements draw predominantly on experimental models, this reliance is generally evident from the context and figure captions.
The figures and tables are a particular strength: they are legible and logically staged, helping readers to connect upstream triggers with downstream consequences. The therapeutic summary table facilitates the rapid understanding of mechanisms and biological implications. These visual elements are well aligned with the narrative and add real pedagogical value for both basic and translational audiences.
The references are recent and relevant to the field, supporting the article’s objective of providing a contemporary snapshot; the selection naturally reflects the chosen time window. The language and presentation are clear and concise throughout, with only minor stylistic repetitions that do not affect readability.
In terms of caveats intrinsic to the scope, the translational sections largely build on preclinical evidence, and readers should bear this in mind when interpreting the clinical implications. These features are consistent with the declared intent and format, and do not detract from the synthesis's clarity or credibility."
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Chen KR, Chen ZY, Liu FY, Xie CY, Hu J, Wang SY, Xu B, Xu TC. Macrophage-mediated metabolic dysregulation in the pancreas: Insights from obesity. World J Biol Chem 2025; 16(4): 109509
18
"Dear authors,
Your study addresses an important and biologically plausible link between CD36, lipid handling, insulin resistance ..."
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"Dear authors,
Your study addresses an important and biologically plausible link between CD36, lipid handling, insulin resistance and gestational diabetes. The laboratory methods are clearly described and can be replicated, and the sample size is respectable for a candidate gene study. The ethical oversight, informed consent and transparency regarding conflicts of interest are all appropriately stated, and the inclusion of STROBE is also appreciated. These provide solid foundations for credibility and reproducibility.
That said, several analytical and design refinements would substantially strengthen the weight of evidence for your conclusions. Due to the baseline imbalances between cases and controls with regard to age, BMI, blood pressure, lipid profile and family history, we recommend re-estimating the effects of genotypes using multivariable logistic regression and reporting the adjusted odds ratios (with 95% confidence intervals) under explicit genetic models (additive, dominant and recessive). This step is critical to disentangling the genotype signal from clinical confounding factors and quantifying the independent contribution of rs1761667 and rs75326924 to GDM risk. You should also report Hardy–Weinberg equilibrium in controls, call rates and any blinded re-genotyping or Sanger validation of samples that you have performed. These quality checks are standard in genetic association studies and will alleviate concerns about genotyping error or differential misclassification.
Moreover, while the transcriptional results are interesting, they would benefit from further characterisation. As CD36 mRNA was measured in peripheral blood leukocytes, please discuss the biological validity of using this tissue as a proxy for those directly implicated in GDM, such as the placenta, adipose tissue and skeletal muscle. If available, orthogonal validation in an independent subset or correlation with insulin resistance indices (e.g. HOMA-IR) would strengthen the argument for functional relevance beyond statistical association.
These additions would increase the reproducibility and translational resonance of your work."
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Shamsad A, Gautam T, Singh R, Banerjee M. CD36 fatty-acid-transporter gene variants-CD36 G/A (rs1761667) and CD36 C/T (rs75326924) as biomarkers for risk-prediction in gestational diabetes mellitus. World J Biol Chem 2025; 16(4): 111104
19
" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..."
[Read more]
" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Jia ZD, Zhang CY, Liang SZ, Li HL. Primary splenic histiocytic sarcoma: A case report and review of literature. World J Clin Cases 2026; 14(3): 116125
20
"Authors overviewed the urinary biomarkers in diabetic kidney disease in present review article. They appropriately acknowledged ..."
[Read more]
"Authors overviewed the urinary biomarkers in diabetic kidney disease in present review article. They appropriately acknowledged diabetic kidney disease as a major global health burden with significant cardiovascular and mortality implications. Unmet clinical need was reflected by emphasis of early detection and intervention. The review covered a range of urinary biomarkers, including traditional markers (albuminuria), tubular injury markers (KIM-1, NGAL), metabolomic signatures, genetic and epigenetic contributors. Hence, authors captured the complexity of DKD pathophysiology with present multidimensional approach.
However, the review could benefit from clearer comparisons between biomarkers in terms of sensitivity, specificity, and predictive value for DKD progression."
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Gembillo G, Soraci L, Messina R, Lo Cicero L, Spadaro G, Cuzzola F, Calderone M, Ricca MF, Di Piazza S, Sudano F, Peritore L, Santoro D. Urinary biomarkers of diabetic kidney disease. World J Diabetes 2026; 17(1): 110502
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Peer-Reviewers and Manuscript Statistics
- Editorial board members
- 2264
- Peer-reviewers
- 35847
- Manuscripts received today
- 0
- Manuscript reviews today
- 0
- Unhandled manuscripts today
- 169
- Active peer-reviewers today
- 288
- Reviewer acceptance today
- 2
- Reviewer refusals today
- 1
- Total accepted manuscripts
- 39827
- Total rejected manuscripts
- 44475
- Total peer-reviewers
- 4660343
- Total submissions
- 37750
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1
"In this paper, the tumor indicators of patients with gastric cancer after operation were detected and analyzed. It was found that ..."
[Read more]
"In this paper, the tumor indicators of patients with gastric cancer after operation were detected and analyzed. It was found that CEA and AFP were closely related to the recurrence of gastric cancer, which provided a good basis for judging the health level of patients with gastric cancer after operation. But it also needs the support of large-scale clinical data. At the same time, patients with gastric cancer need more tumor indicators to explore a better combination for judging the prognosis of patients with gastric cancer. "
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Duan XX, Yu X, Zhou L. Timeliness of postoperative serum carcinoembryonic antigen monitoring for predicting recurrence after gastric cancer surgery. World J Gastrointest Surg 2026; 18(1): 114309
2
"Dear Editor, I am writing in response to your invitation to comment on the prospective study by Güneş et al., entitled “Diagnostic ..."
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"Dear Editor, I am writing in response to your invitation to comment on the prospective study by Güneş et al., entitled “Diagnostic value of interleukin-8 in colon cancer,” published in your esteemed journal. The authors provide valuable data reinforcing the role of interleukin-8 (IL-8) as an independent diagnostic biomarker in colon adenocarcinoma. Their work rightly concludes that IL-8 holds promise, particularly as part of a multi-marker panel. I would like to extend this discussion by contextualizing IL-8 within the current, rapidly evolving biomarker landscape of colorectal cancer (CRC), as recently elaborated in an editorial on this topic. The future of CRC management lies in a dynamic, multi-layered biomarker strategy that integrates three key pillars: 1) Mismatch repair (MMR) status to dictate therapeutic class (chemotherapy vs. immunotherapy); 2) Perioperative carcinoembryonic antigen (CEA) for immediate risk stratification, especially within microsatellite stable (MSS) disease; and 3) Postoperative circulating tumor DNA (ctDNA) as a dynamic tool to guide treatment intensity and de-escalation, as definitively demonstrated by the recent AGITG DYNAMIC-III trial. In this framework, the findings on IL-8 by Güneş et al. present a compelling opportunity. While its standalone diagnostic accuracy (AUC=0.68) is moderate, its independent predictive value suggests a distinct biological role, likely rooted in its pro-inflammatory and angiogenic functions. This positions IL-8 not as a replacement for the aforementioned pillars, but as a potential complementary element, particularly within the MSS cohort. Specifically, IL-8 could enhance the second pillar (risk stratification) by providing additional biological granularity. For instance, in MSS patients with normal or borderline CEA levels, an elevated IL-8 might signal a more aggressive tumor biology driven by inflammation, potentially identifying a subset that would benefit from closer surveillance or adjuvant therapy. Furthermore, given its link to angiogenesis and immune modulation, IL-8 merits investigation as a predictive biomarker for responses to anti-angiogenic therapies (e.g., bevacizumab) and possibly immunotherapy, even in MSS/pMMR tumors. Therefore, I propose that the next logical step for research, as inspired by both this study and the broader editorial perspective, is to evaluate IL-8 within integrated multi-marker panels. Combining IL-8 with CEA, ctDNA, and potentially other inflammatory markers (e.g., CRP) in algorithm-driven models could significantly improve diagnostic sensitivity, prognostic stratification, and predictive accuracy. This approach aligns perfectly with the paradigm of dynamic precision oncology, where multiple data streams are synthesized to guide personalized therapeutic navigation. I congratulate the authors on their contribution and thank you for the opportunity to share these perspectives, hoping they may stimulate further research into the integrative potential of IL-8 within the modern CRC biomarker ecosystem. Sincerely, Pr Nabil Ismaili Mohammed VI University of Sciences and Health (UM6SS), Mohammed VI Foundation of Sciences and Hrealth (FM6SS), Casablanca, Morocco, nismaili@um6ss.ma, 0000-0001-5786-5134 "
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Güneş G, Fırat Oğuz E, Kayılıoğlu I, Dinç T. Diagnostic value of interleukin-8 in colon cancer: Prospective, case-control study. World J Gastrointest Surg 2026; 18(1): 115444
3
"Systemic antifungal therapy is the backbone of treatment for invasive fungal infections, but it carries an under-recognized burden ..."
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"Systemic antifungal therapy is the backbone of treatment for invasive fungal infections, but it carries an under-recognized burden of endocrine and physiological toxicity. The review by Thakkar et al. (2026) provides an important framework for understanding how these agents affect human cytochrome P450 enzymes and renal function, leading to adrenal insufficiency, mineralocorticoid excess, and electrolyte abnormalities. This review deserves recognition, and adding a global perspective to it could provide new recommendations. If possible, I would like to submit a letter addressing this perspective. "
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Thakkar S, Kantroo V, Nagendra L, Dutta D, Kamrul-Hasan ABM, Kalra S, Bhattacharya S. Endocrine consequences of antifungal therapy: A missed entity. World J Clin Cases 2026; 14(2): 117140
4
"I read with interest the study comparing the ASGE lexicon and the AGREE classification for adverse events in gastrointestinal ..."
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"I read with interest the study comparing the ASGE lexicon and the AGREE classification for adverse events in gastrointestinal endoscopy. The authors are to be commended for their rigorous analysis of a large institutional registry and for highlighting the conceptual differences between two widely used adverse event frameworks. The high concordance observed between ASGE and AGREE confirms that both systems are robust for capturing clinically significant complications. However, the discordance noted for transient cardiorespiratory and sedation-related events raises an important interpretive issue. The ASGE lexicon intentionally captures such occurrences as “incidents,” supporting quality improvement and preventive strategies, whereas AGREE excludes many of these events by design, prioritising clinical consequence and post-procedural intervention. While this approach improves specificity, it may inadvertently narrow the safety signal. From a patient-centred perspective, events such as inadequate sedation, procedural discomfort, or transient hypoxia—although self-limiting—can significantly influence patient-reported experience, satisfaction, and trust in endoscopic services. These experiential harms may not require escalation of care yet remain meaningful to patients and may affect willingness for repeat procedures. Their exclusion from adverse event datasets risks underestimating quality concerns that are increasingly relevant in value-based care. The study also underscores that adverse event classification represents only one dimension of endoscopy quality. Domains such as procedural appropriateness, missed or delayed diagnoses, bowel preparation adequacy, photodocumentation quality, scheduling delays, and patient-initiated procedure termination are not captured by adverse event frameworks but are integral to comprehensive quality assessment. In summary, while standardised adverse event classification remains essential for benchmarking and safety governance, it should be complemented by patient-reported experience measures and broader quality indicators. A multidimensional framework integrating safety, experience, and appropriateness may better align endoscopy quality metrics with contemporary patient-centred practice. "
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Corsi O, Martinez R, Aguirre J, Friedrich I, Galeno V, Jimenez V, Briones P, Díaz LA, Espino A, Vargas JI. Application of a novel adverse event classification scale in a Latin American gastrointestinal endoscopy unit. World J Gastrointest Endosc 2026; 18(1): 111384
5
"This minireview provides a timely and balanced synthesis of the evolving role of endoscopic ultrasound-guided radiofrequency ablation ..."
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"This minireview provides a timely and balanced synthesis of the evolving role of endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) in the management of pancreatic neuroendocrine tumors (pNETs). The authors appropriately frame EUS-RFA as a promising yet still selective therapeutic option, and the “lights and shadows” construct is effective in highlighting both its clinical potential and its current limitations A major strength of the article lies in its comprehensive collation of published clinical experience across functioning and non-functioning pNETs. The tabulated summaries are particularly valuable for readers seeking an overview of technical success, clinical response, and adverse event profiles. Importantly, the authors avoid overstating efficacy and consistently acknowledge the predominance of retrospective series, limited follow-up durations, and heterogeneity in response definitions—an intellectua rigour that strengthens the manuscript. From a conceptual standpoint, the review highlights a key paradigm shift: EUS-RFA is no longer merely a salvage or palliative modality, but a potential intermediate option within the “grey zone” of small, low-grade pNETs, especially in patients unfit for surgery or those prioritizing minimally invasive approaches. This raises an important clinical question not fully resolved in current guidelines—whether EUS-RFA should eventually be positioned as a disease-modifying therapy rather than an alternative to surveillance. The discussion on radiological response assessment underscores a critical unmet need in the field. The lack of standardized imaging endpoints, timing of follow-up, and correlation with long-term oncologic outcomes limits meaningful comparison across studies. Future consensus on response metrics—possibly integrating contrast-enhanced harmonic EUS, cross-sectional imaging, and biochemical markers—would significantly enhance interpretability and clinical adoption. Finally, the article appropriately calls attention to procedural standardization and risk mitigation, particularly regarding pancreatitis prevention and proximity to the main pancreatic duct. These considerations will be central if EUS-RFA is to move beyond expert centers into broader clinical practice. Overall, this review serves as a valuable reference for gastroenterologists, endosonographers, and multidisciplinary teams managing pNETs. It also clearly delineates the research priorities required before EUS-RFA can be fully integrated into evidence-based treatment algorithms. "
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Tringali A, Caiazzo A. Role of endoscopic ultrasound in the treatment of pancreatic neuroendocrine tumors: Lights and shadows of endoscopic ultrasound-guided radiofrequency ablation. World J Gastrointest Endosc 2026; 18(1): 113617
6
"Commentary: Clinical Considerations in Immunocompromised Patients With Edwardsiella tarda–Associated Spontaneous Bacterial Peritonitis ..."
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"Commentary: Clinical Considerations in Immunocompromised Patients With Edwardsiella tarda–Associated Spontaneous Bacterial Peritonitis The case report by Usuda et al., recently published in the World Journal of Clinical Cases, represents a notable contribution to clinical microbiology by documenting, to the best of current knowledge, the first reported case of spontaneous bacterial peritonitis (SBP) caused by Edwardsiella tarda in an immunocompromised patient undergoing dialysis [1].This report substantially expands the recognized infectious spectrum in patients with end-stage renal disease (ESRD) and underscores the need for heightened clinical awareness of atypical and opportunistic pathogens in this vulnerable population. One particularly commendable aspect of this report is the authors’ detailed discussion of the virulence mechanisms of E. tarda. The organism’s capacity to survive and replicate within macrophages plays a pivotal role in its pathogenicity, especially in hosts with compromised cellular immunity [2,3]. In the present case, the coexistence of diabetic nephropathy and long-term dialysis likely created a permissive immunological milieu that facilitated this opportunistic infection. Such intracellular persistence provides a plausible explanation for the severe and insidious clinical course observed, even in the absence of classical epidemiological exposures such as raw seafood consumption or contact with freshwater environments. Equally noteworthy is the authors’ adherence to principles of antimicrobial stewardship. The stepwise transition from empirical broad-spectrum therapy with cefmetazole to targeted, de-escalated treatment using cefalexin—guided by comprehensive antimicrobial susceptibility testing (Table 3)—offers a valuable therapeutic reference for clinicians managing similarly rare infections. Nevertheless, building on the authors’ insightful acknowledgment of the limitations surrounding “ascites culture conversion,” I would like to propose a more structured and rigorous framework for defining treatment endpoints in such high-risk cases. While clinical and symptomatic improvement remains an essential marker of response, it may be insufficient when dealing with pathogens such as E. tarda, which possess the ability to persist intracellularly [4,5]. Accordingly, I suggest an integrated “imaging-to-microbiology” strategy prior to antibiotic discontinuation. First, advanced imaging modalities—such as abdominal computed tomography or high-resolution ultrasonography—should be systematically incorporated to objectively assess the resolution of ascites. Complete radiological absorption of ascitic fluid would substantially strengthen the clinical justification for treatment cessation. Conversely, if residual ascites is detected, even in minimal or loculated forms, reliance on systemic inflammatory markers such as C-reactive protein or leukocyte counts alone may be misleading. Given the organism’s persistence potential [3], repeat diagnostic paracentesis should be strongly considered to confirm microbiological eradication. This dual confirmation—radiological and microbiological—would provide a more robust and evidence-based rationale for terminating antimicrobial therapy [6], thereby reducing the risk of relapse in immunocompromised patients. In conclusion, while this case report fills an important gap in the current literature, it also highlights the need to refine discharge and treatment-completion criteria for rare causes of SBP. Adoption of an imaging-guided microbiological confirmation strategy may enhance the precision of clinical decision-making and ultimately improve long-term outcomes in patients with complex comorbidities. 参考文献 [1]Usuda D , Furukawa D, Imaizumi R et al. Spontaneous bacterial peritonitis due to Edwardsiella tarda in an immuno-compromised dialysis patient: A case report and review of literature. World J Clin Cases 2026,6; 14(1): 115102. [2][2]Qin L, Li F, Wang X, Sun Y, Bi K, Gao Y. Proteomic analysis of macrophage in response to Edwardsiella tarda-infection. Microb Pathog, 2017; 111: 86-93 [RCA] [PMID: 28826764 DOI: 10.1016/j.micpath.2017.08.028] [3]Zhang L, Ni C, Xu W, Dai T, Yang D, Wang Q, Zhang Y, Liu Q. Intramacrophage Infection Reinforces the Virulence of Edwardsiella tarda. J Bacteriol 2016; 198: 1534-1542 [RCA] [PMID: 26953340 DOI: 10.1128/JB.00978-15] [4]An L, Chan JL, Nguyen M, Yang S, Deville JG. Case Report: Disseminated Edwardsiella tarda infection in an immunocompromised patient. Front Cell Infect Microbiol 2023; 13: 1292768 [RCA] [PMID: 38053529 DOI: 10.3389/fcimb.2023.1292768] [5]Matsukawa H, Usuda D, Takami H, Nomura T, Sugita M. A Case of Edwardsiella tarda Infection With Iliopsoas Abscess Following Acute Pyelonephritis. Cureus 2024; 16: e58868 [RCA] [PMID: 38800258 DOI: 10.7759/cureus.58868] [6]A Rimola , G García-Tsao, M Navasa, L J Piddock, R Planas, B Bernard, J M Inadomi. Diagnosis, treatment and prophylaxis of spontaneous bacterial peritonitis: a consensus document. International Ascites Club. J Hepatol, 2000; 32(1):142-53[RCA][PMID: 10673079 DOI: 10.1016/s0168-8278(00)80201-9] "
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Usuda D, Furukawa D, Imaizumi R, Ono R, Kaneoka Y, Nakajima E, Kato M, Sugawara Y, Shimizu R, Inami T, Kawai K, Matsubara S, Tanaka R, Suzuki M, Shimozawa S, Hotchi Y, Osugi I, Katou R, Ito S, Mishima K, Kondo A, Mizuno K, Takami H, Komatsu T, Nomura T, Sugita M. Spontaneous bacterial peritonitis due to Edwardsiella tarda in an immuno-compromised dialysis patient: A case report and review of literature. World J Clin Cases 2026; 14(1): 115102
7
"This paper presents a systematic retrospective analysis of the incidence and clinical significance of gallstones and gallbladder wall ..."
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"This paper presents a systematic retrospective analysis of the incidence and clinical significance of gallstones and gallbladder wall thickening in patients with liver cirrhosis, offering valuable clinical observations for practitioners. The study clearly indicates that the prevalence of gallbladder abnormalities—including gallstones and asymptomatic wall thickening—is significantly higher in patients with cirrhosis, especially in the decompensated stage, compared to the general population. This finding aligns with previous research and further supports the pivotal role of portal hypertension and hepatic dysfunction in the development of gallbladder pathology. Notably, the authors emphasize that these imaging findings are often related to cirrhosis itself rather than being indicators of acute cholecystitis. This distinction is clinically important, as it can help prevent unnecessary interventions—such as misdiagnosis and surgery for presumed acute cholecystitis—particularly in asymptomatic individuals. Moreover, the study suggests that gallbladder abnormalities correlate more strongly with the decompensated state of cirrhosis than with its etiology, providing a fresh perspective on the mechanisms underlying gallbladder changes in these patients. However, several limitations should be acknowledged. First, the retrospective design and single-center sample may limit the generalizability of the results. Second, the study lacks in-depth analysis of subgroups based on the etiology of cirrhosis, leaving it unclear whether findings differ notably in non-alcoholic liver disease patients. Finally, potential influencing factors such as gallbladder motility and medication use were not systematically evaluated, even though they may contribute to wall thickening and stone formation. Overall, this paper offers practical clinical insights into the imaging assessment of the gallbladder in cirrhotic patients. Future prospective, multicenter studies incorporating more pathophysiological parameters—such as gallbladder motility and bile composition—could help further elucidate the complex relationship between cirrhosis and gallbladder disorders and contribute to optimized clinical decision-making. "
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Tsankof A, Protopapas AA, Kyritsi V, Gogou C, Kyziroglou M, Papathanasiou E, Chatzikosma C, Michalopoulos A, Savopoulos C, Protopapas AN. Gallstones and gallbladder wall thickening in patients with cirrhosis: Prevalence and clinical impact. World J Clin Cases 2026; 14(1): 114043
8
"This meta-analysis systematically retrieved and synthesized evidence from 30 randomized controlled trials (RCTs) involving nearly ..."
[Read more]
"This meta-analysis systematically retrieved and synthesized evidence from 30 randomized controlled trials (RCTs) involving nearly 17,000 patients, providing the most comprehensive assessment to date on the efficacy of indomethacin for preventing post-ERCP pancreatitis (PEP). It offers valuable, up-to-date evidence-based references for clinical practice, and the authors' efforts are highly commendable. Nevertheless, while acknowledging its contributions, two critical methodological limitations must be highlighted, which may compromise the interpretation and generalizability of its findings. The present commentary aims to identify two key methodological flaws in this meta-analysis that seriously undermine the statistical validity and clinical interpretability of its results. First, the authors inappropriately disaggregated seven multi-arm randomized controlled trials into multiple independent pairwise comparisons for inclusion in the analysis. This practice directly violates the core assumption of data independence in meta-analyses: different comparison groups derived from the same trial are correlated due to the shared control arm. Treating these as independent samples artificially inflates the total sample size, misestimates the weight of each study, and leads to an inappropriate narrowing of confidence intervals, thereby increasing the risk of Type I or Type II errors. Second, the definition of the "control group" in the study encompasses interventions with extremely high clinical heterogeneity, including placebo, normal saline, other active medications (e.g., diclofenac, somatostatin), and invasive procedures (e.g., pancreatic duct stenting). Pooling these controls with vastly different mechanisms of action and therapeutic efficacies renders the reported pooled relative risk (RR = 0.85) clinically meaningless. Furthermore, the high heterogeneity observed (I² = 79%) is most likely attributable to this flawed methodological design. In summary, the aforementioned issues cast doubt on the statistical credibility of the primary conclusion—that "indomethacin does not significantly reduce the incidence of PEP"—and also make it difficult to provide a reasonable clinical interpretation for practice. Given that this review incorporates multiple interrelated interventions for comparison, network meta-analysis would represent a more appropriate methodological framework. It can rigorously integrate data from multi-arm trials and simultaneously evaluate the relative efficacy of all relevant preventive strategies. "
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Tian F, Huang ZC, Khizar H, Qiu K. Efficacy of indomethacin for the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis: A comprehensive meta-analysis of randomized controlled trials. World J Gastroenterol 2026; 32(1): 113232
9
"This meta-analysis systematically retrieved and synthesized evidence from 30 randomized controlled trials (RCTs) involving nearly ..."
[Read more]
"This meta-analysis systematically retrieved and synthesized evidence from 30 randomized controlled trials (RCTs) involving nearly 17,000 patients, providing the most comprehensive assessment to date on the efficacy of indomethacin for preventing post-ERCP pancreatitis (PEP). It offers valuable, up-to-date evidence-based references for clinical practice, and the authors' efforts are highly commendable. Nevertheless, while acknowledging its contributions, two critical methodological limitations must be highlighted, which may compromise the interpretation and generalizability of its findings. The present commentary aims to identify two key methodological flaws in this meta-analysis that seriously undermine the statistical validity and clinical interpretability of its results. First, the authors inappropriately disaggregated seven multi-arm randomized controlled trials into multiple independent pairwise comparisons for inclusion in the analysis. This practice directly violates the core assumption of data independence in meta-analyses: different comparison groups derived from the same trial are correlated due to the shared control arm. Treating these as independent samples artificially inflates the total sample size, misestimates the weight of each study, and leads to an inappropriate narrowing of confidence intervals, thereby increasing the risk of Type I or Type II errors. Second, the definition of the "control group" in the study encompasses interventions with extremely high clinical heterogeneity, including placebo, normal saline, other active medications (e.g., diclofenac, somatostatin), and invasive procedures (e.g., pancreatic duct stenting). Pooling these controls with vastly different mechanisms of action and therapeutic efficacies renders the reported pooled relative risk (RR = 0.85) clinically meaningless. Furthermore, the high heterogeneity observed (I² = 79%) is most likely attributable to this flawed methodological design. In summary, the aforementioned issues cast doubt on the statistical credibility of the primary conclusion—that "indomethacin does not significantly reduce the incidence of PEP"—and also make it difficult to provide a reasonable clinical interpretation for practice. Given that this review incorporates multiple interrelated interventions for comparison, network meta-analysis would represent a more appropriate methodological framework. It can rigorously integrate data from multi-arm trials and simultaneously evaluate the relative efficacy of all relevant preventive strategies. "
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Ding Y, Wang CY, Pan YT, Wang YJ, Zhao AG, Wen HZ. Scutellaria baicalensis Georgi as a potential therapeutic drug intervention in ulcerative colitis: Mechanisms of action and clinical trials. World J Gastroenterol 2026; 32(1): 114558
10
"I read the excellent paper by Rajak et al. The review is organized and precisely addresses the role of microplastics in inducing ..."
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"I read the excellent paper by Rajak et al. The review is organized and precisely addresses the role of microplastics in inducing metabolic-associated steatotic liver disease and its progression. The review raises a growing emergency: the relationship between air pollution and human health. This can be a stimulus for policymakers and international organizations to take concrete action. However, it should be remembered that a proper lifestyle can mitigate the negative impact of microplastics on the liver and human health in general. While waiting for long-term measures, this is information that can yield short-term results. On this issue, it will be my concern to send a letter to the editor. Sincerely, Gianni Testino "
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Rajak S, Shahi A, Yadav A, Medhe P, Sinha RA. Microplastics in metabolic dysfunction-associated steatotic liver disease: An emerging threat to liver health. World J Hepatol 2025; 17(12): 111198
11
"1.The article does not cover the temporal and spatial dynamic changes of inflammatory cytokines during the development of NSCLC, as ..."
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"1.The article does not cover the temporal and spatial dynamic changes of inflammatory cytokines during the development of NSCLC, as well as how these changes affect the occurrence and development of drug resistance. For instance, are there any differences in the expression levels of inflammatory cytokines in the early stage, progression stage, and resistance stage of the tumor? Are their distributions different in various parts of the tumor (such as the primary lesion and metastatic lesion)? It is suggested to utilize techniques such as in situ hybridization and immunohistochemistry, combined with single-cell sequencing and spatial transcriptomics, to study the temporal and spatial dynamic changes of inflammatory cytokines in different development stages and different locations of NSCLC. By analyzing longitudinal samples of patients (such as before treatment, during treatment, and after resistance), the dynamic change patterns of inflammatory cytokines during the process of drug resistance can be revealed. 2. Although IL-6R blockade shows the effect of reversing drug resistance, single-target therapy may have limitations in efficacy or the risk of drug resistance escape. It is suggested to explore IL-6/IL-8 dual-target inhibition in preclinical models, or to combine it with downstream pathway inhibitors (such as JAK/STAT, PI3K/AKT, NF-κB inhibitors) or immune checkpoint inhibitors to evaluate its synergistic anti-tumor effect and its remodeling effect on the tumor microenvironment, in order to provide theoretical basis for future clinical trials of combination therapy. "
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Calibasi-Kocal G. Inflammatory cytokine-associated cisplatin resistance in non-small cell lung cancer and re-sensitization through interleukin-6 receptor blockade. World J Clin Oncol 2025; 16(12): 114275
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"Author: Priya Hazrah Professor, Department of Surgery, Lady Hardinge Medical College, New Delhi. Email: priyahazrah@gmail.com, ORCID ..."
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"Author: Priya Hazrah Professor, Department of Surgery, Lady Hardinge Medical College, New Delhi. Email: priyahazrah@gmail.com, ORCID ID 0009-0008-1915-3978 Deborshi Sharma Director Professor Department of Surgey ABVIMS, New Delhi. Email: drdeborshi@gmail.com, ORCID ID 0000-0001-8251-8484 Sonali Mittal Assistant professor, Lady Hardinge Medical College, New Delhi Email: sonali.prachi@gmail.com, ORCID 0000-0002-6289-7656 Corresponding Author: Priya Hazrah Professor Department of Surgery, Lady Hardinge Medical College, New Delhi. Email: priyahazrah@gmail.com We read with tremendous interest your article entitled “Mastering the third space: Innovations in intramural endoscopic surgery for gastrointestinal disorders.” It was a very apt and concise review of commonly performed third space endoscopy (TSE) procedures, namely the C, Z, E, and G POEM (per oral endoscopic myotomy). Here, we would like to highlight other evolving procedures related to third space endoscopy and also the emerging concept of “fourth space endoscopy.” POETRE, peroral esophageal tunnelling for restoration of the esophagus, based on the principle of TSE, is an innovative technique of submucosal tunnelling proposed to be a useful therapeutic option in long-segment complete esophageal luminal obstruction in a few case series [1, 2]. PREM/PAEM (per rectal/per anal myotomy) is another novel use of TSE with limited exploration in patients with Hirschsprung’s disease [3]. STER (submucosal tunnelling endoscopic resection) and POET (peroral endoscopic excision of tumor) have been reported to be safe procedures for resection of extramucosal tumors in the upper gastrointestinal tract with acceptable complication rates vouched for in recent meta-analyses [4-7]. Further, TSE can be used to gain peritoneal access, as seen in POEM+F (POEM with fundoplication). Building upon the model of third space endoscopy is a forthcoming concept of fourth space endoscopy based on the technique of sub-serosal dissection for excision of extramucosal tumors in the upper gastrointestinal tract, like gastrointestinal stromal tumors, leiomyoma, hamartoma, etc., published in a limited case series [8]. The feasibility of using the principle of the fourth-space endoscopy procedure for vagotomy is investigational and has been reported currently in an anecdotal non-human study [9]. The fourth space is also utilized at times in POEM to enable a full-thickness myotomy [10]. References 1. Wagh MS, Draganov PV. Per-oral endoscopic tunneling for restoration of the esophagus: a novel endoscopic submucosal dissection technique for therapy of complete esophageal obstruction. Gastrointest Endosc. 2017 Apr;85(4):722-727. doi: 10.1016/j.gie.2016.08.035. Epub 2016 Sep 7. PMID: 27612924. 2. Félix C, Barreiro P, Rodrigues Azevedo J, Maia L, Küttner-Magalhães R, Pedroto I, Chagas C. Per-oral endoscopic tunneling for restoration of the esophagus (POETRE) in the management of a complete esophageal obstruction. Endosc Int Open. 2021 Jul;9(7):E1084-E1085. doi: 10.1055/a-1463-3059. Epub 2021 Jun 17. PMID: 34222634; PMCID: PMC8211479. 3. Bapaye A, Dashatwar P, Biradar V, Biradar S, Pujari R. Initial experience with per-rectal endoscopic myotomy for Hirschsprung's disease: medium and long term outcomes of the first case series of a novel third-space endoscopy procedure. Endoscopy. 2021 Dec;53(12):1256-1260. doi: 10.1055/a-1332-6902. Epub 2021 Mar 2. PMID: 33291158. 4. Onimaru M, Inoue H, Bechara R, Tanabe M, Abad MRA, Ueno A, Shimamura Y, Sumi K, Ikeda H, Ito H. Clinical outcomes of per-oral endoscopic tumor resection for submucosal tumors in the esophagus and gastric cardia. Dig Endosc. 2020 Mar;32(3):328-336. doi: 10.1111/den.13471. Epub 2019 Jul 22. PMID: 31234231. 5. Peng W, Tan S, Huang S, Ren Y, Li H, Peng Y, Fu X, Tang X. Efficacy and safety of submucosal tunneling endoscopic resection for upper gastrointestinal submucosal tumors with more than 1-year' follow-up: a systematic review and meta-analysis. Scand J Gastroenterol. 2019 Apr;54(4):397-406. doi: 10.1080/00365521.2019.1591500. Epub 2019 Mar 29. PMID: 30925071. 6. Song S, Wang X, Zhang S, Li Y, Zhang X, Chu X. Efficacy and complications of submucosal tunneling endoscopic resection for upper gastrointestinal submucosal tumors and exploration for influencing factors. Z Gastroenterol. 2018 Apr;56(4):365-373. English. doi: 10.1055/s-0043-123765. Epub 2018 Jan 18. PMID: 29346827. 7. Cao B, Lu J, Tan Y, Liu D. Efficacy and safety of submucosal tunneling endoscopic resection for gastric submucosal tumors: a systematic review and meta-analysis. Rev Esp Enferm Dig. 2021 Jan;113(1):52-59. doi: 10.17235/reed.2020.6989/2020. PMID: 33222480. 8. Liu F, Zhang S, Ren W, Yang T, Lv Y, Ling T, Zou X, Wang L. The fourth space surgery: endoscopic subserosal dissection for upper gastrointestinal subepithelial tumors originating from the muscularis propria layer. Surg Endosc. 2018 May;32(5):2575-2582. doi: 10.1007/s00464-017-5985-z. Epub 2017 Dec 20. PMID: 29264757. 9. Kadkhodayan K, Irani S. Endoscopic truncal vagotomy. Exploring the fourth space. A technical feasibility study in a porcine model. VideoGIE. 2025 Mar 4;10(7):340-344. doi: 10.1016/j.vgie.2025.02.012. PMID: 40642399; PMCID: PMC12237756. 10. Jiang T, Yang Y, Luo W. Application of the fourth space in peroral endoscopic myotomy (POEM) surgery for achalasia. Rev Esp Enferm Dig. 2025 Jun 27. doi: 10.17235/reed.2025.11331/2025. Epub ahead of print. PMID: 40575899. "
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Restrepo-Rodas G, Rodriguez J. Mastering the third space: Innovations in intramural endoscopic surgery for gastrointestinal disorders. World J Gastrointest Endosc 2025; 17(12): 111206
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"This article addresses an important and timely topic: differentiation-based strategies for colorectal cancer (CRC) therapy using ..."
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"This article addresses an important and timely topic: differentiation-based strategies for colorectal cancer (CRC) therapy using natural products. The authors present a comprehensive in vitro study suggesting that Ferula assafoetida (FA) induces differentiation and apoptosis in Caco-2 colon cancer cells, potentially via activation of the JNK/MAPK pathway. As a reader, the work is interesting, methodologically broad, and conceptually aligned with current interests in natural compound–based cancer therapeutics, although certain conceptual and interpretative gaps limit its translational impact. As a reader, I would regard this article as a useful exploratory study that justifies further mechanistic, protein-level, and in vivo investigations, rather than a conclusive demonstration of FA as a differentiation therapy for CRC. "
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Abdelsalam HM, Abdelghany AM, Ahmed WA, Diab AA, Abdellateif MS. Ferula assafoetida induced colon cancer cells differentiation through JNK/MAPK signalling pathway activation. World J Exp Med 2025; 15(4): 110757
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"his retrospective study by Cooper et al. provides a valuable comparison of endoscopic band ligation (EBL) and endoscopic thermal ..."
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"his retrospective study by Cooper et al. provides a valuable comparison of endoscopic band ligation (EBL) and endoscopic thermal therapy (ETT) as initial treatments for nodular gastric antral vascular ectasia (GAVE), a rare and challenging subtype. The analysis of 37 patients demonstrates that EBL outperforms ETT, with significantly higher clinical remission rates (90% vs. 69%, P=0.041), shorter treatment intervals (172 vs. 928 days, P=0.013), and fewer required endoscopic sessions (1.95 vs. 5.56, P=0.009), supported by improved hemoglobin levels and reduced transfusions. The findings robustly advocate for EBL as a first-line approach due to its efficiency and lower treatment burden. However, limitations include the small sample size, single-center design, and retrospective nature, which may affect generalizability. Despite this, the study fills a critical gap in nodular GAVE management and underscores the need for prospective multicenter trials to validate EBL's superiority and optimize clinical protocols. "
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Cooper JA, Statham E, Holyfield A, Shoreibah MG, Peter S. Initial treatment approaches for nodular gastric antral vascular ectasia: A comparison of endoscopic band ligation and thermal therapies. World J Gastrointest Endosc 2025; 17(12): 111872
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"The minireview by El Dada et al. offers a timely synthesis of endoscopic ultrasound (EUS)-guided coil embolization for gastric varices ..."
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"The minireview by El Dada et al. offers a timely synthesis of endoscopic ultrasound (EUS)-guided coil embolization for gastric varices (GVs), highlighting its potential as a safer, precise alternative to traditional therapies like cyanoacrylate injection. Strengths include systematic comparisons with meta-analytic data (e.g., 96.7% obliteration rate for EUS-coil/cyanoacrylate vs. 70.6% for cyanoacrylate alone), practical technical details (coil selection, Doppler confirmation), real-world case illustrations, and cost-effectiveness analysis (1,831vs.11,000 hospitalization). However, limitations persist: reliance on retrospective/single-center data, absence of randomized controlled trials (RCTs) against TIPS/BRTO, and lack of long-term (>5 years) rebleeding/complication data (e.g., coil migration). The authors appropriately call for multicenter RCTs to standardize protocols, explore material combinations, and integrate predictive biomarkers. Despite gaps, the review compellingly argues for EUS-coil’s inclusion in GV guidelines, serving as a valuable reference for advancing therapeutic endoscopy with balanced analysis of efficacy, safety, and accessibility. "
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El Dada A, El Khoury M, Stephan P, Nehme F. Endoscopic ultrasound-guided coil embolization for gastric varices: A promising alternative to traditional therapies. World J Gastrointest Endosc 2025; 17(12): 110168
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"Name of Journal: World Journal of Gastroenterology Manuscript Type: LETTER TO THE EDITOR Dialister-Associated Succinate Dysregulation ..."
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"Name of Journal: World Journal of Gastroenterology Manuscript Type: LETTER TO THE EDITOR Dialister-Associated Succinate Dysregulation in Crohn’s Disease: Clinical and Therapeutic Implications 1Fotios S. Fousekis, 1Konstantinos H. Katsanos, 2Konstantinos Vlachos, 2Georgios D. Lianos 1Department of Gastroenterology, University Hospital of Ioannina, University of Ioannina Ioannina, Greece 2Department of Surgery, University Hospital of Ioannina, University of Ioannina, Greece Corresponding author: Fotios S. Fousekis, MD, PhD, Department of Gastroenterology, University Hospital of Ioannina, University of Ioannina Ioannina, Greece, email: fotisfous@gmail.com Abstract Growing evidence suggests that altered gut microbiota–derived succinate metabolism plays an important role in Crohn’s disease activity and postoperative recurrence. Particular emphasis is placed on Dialister, a gut bacterial genus that consumes succinate inefficiently, potentially leading to its accumulation and increased intestinal inflammation. Elevated succinate may impair immune regulation and enhance inflammatory signaling through SUCNR1 activation and hypoxia-inducible factor-1α stabilization. Recent findings identifying specific Dialister strains associated with postoperative recurrence provide new insight into disease monitoring and risk stratification. Although the study offers an integrative view linking microbial composition, metabolism, and inflammation, further validation using direct metabolomic and shotgun metagenomic approaches is needed. Overall, succinate appears to be a promising biomarker and therapeutic target, supporting future microbiota- and metabolism-based strategies for the management of inflammatory bowel disease. Key words: Crohn’s disease; Inflammatory bowel disease; Gut microbiota; Succinate; Dialister; Postoperative recurrence Core tip Accumulation of the microbial metabolite succinate is increasingly recognized as a key driver of inflammation in Crohn’s disease. Recent evidence links Dialister enrichment to impaired succinate clearance, disease activity, and postoperative recurrence, highlighting succinate as a promising biomarker and therapeutic target in inflammatory bowel disease. To the editor Dialister, an anaerobic Gram-negative genus of the human gut microbiome, has gained clinical interest due to its role in succinate metabolism. While capable of utilizing succinate as a substrate for propionate production, Dialister exhibits relatively slow consumption rates compared with efficient succinate consumers such as Phascolarctobacterium. This inefficiency may result in elevated luminal succinate levels, particularly in the context of inflammatory bowel disease (IBD) (1). Succinate accumulation may disrupt regulatory T cell (Treg) function by promoting FOXP3 degradation, thereby reducing immune tolerance and further amplifying inflammation (2). Furthermore, elevated succinate stabilizes hypoxia-inducible factor-1α (HIF-1α) by inhibiting prolyl hydroxylase activity, which prevents HIF-1α degradation and leads to enhanced inflammatory gene expression and perpetuation of tissue injury, particularly in IBD (3). We read with great interest the recently published article by Boronat-Toscano and colleagues on Dialister-driven succinate accumulation and its association with disease activity and postoperative recurrence in Crohn’s disease (4). This study offers valuable insights into a rapidly growing field of research that links gut microbiota, host metabolism, and inflammation. It positions succinate not just as a metabolic by-product but also as a functional biomarker and potential therapeutic target. One of the major strengths of this work is its integrative, multi-level approach, which combines clinical and biochemical measures of disease activity, such as the Harvey–Bradshaw Index, C-reactive protein, and fecal calprotectin, with gut microbiome profiling using 16S rRNA sequencing and host molecular markers related to succinate signaling, specifically the expression of the succinate receptor SUCNR1 (4). Notably, this study highlights specific Dialister operational taxonomic units (OTUs) in the intestinal mucosa that correlate with the risk and severity of postoperative recurrence. This goes beyond existing knowledge by identifying strain-level microbial signatures with potential predictive value, suggesting that variability within Dialister is vital for patient stratification and disease progression after surgery. The authors also propose a mechanism for succinate accumulation in Crohn's disease, involving the downregulation of NADH dehydrogenase and the upregulation of fumarate reductase and succinate transporters. This metabolic shift enhances succinate production and export by the gut microbiota (4). Despite these strengths, we would like to highlight several issues that merit further discussion. The functional analysis of the gut microbiome is based on predictive approaches (PICRUSt2) rather than on direct measurements of metabolic fluxes or shotgun metagenomic sequencing. Validation of these predictions is essential for robust conclusions. Targeted metabolomic analyses, using mass spectrometry or nuclear magnetic resonance, allow for direct quantification of metabolites as succinate and can confirm the functional activity of predicted pathways (5). In addition shotgun metagenomic sequencing may provide a more comprehensive and direct assessment of the genetic potential for metabolic pathways, including those involved in succinate production and consumption, by sequencing all microbial DNA present in a sample (6). These findings also open important avenues for future research and therapeutic development in inflammatory bowel disease. Given the central role of succinate in promoting intestinal inflammation through SUCNR1 activation and HIF-1α stabilization, strategies aimed at reducing succinate accumulation or blocking its downstream signaling pathways warrant further investigation. Microbiota-targeted interventions, including dietary fiber enrichment, prebiotics, and probiotics designed to enhance the abundance of efficient succinate-consuming bacteria such as Phascolarctobacterium, represent a particularly promising approach, as preclinical studies have demonstrated their ability to lower succinate levels, attenuate inflammatory signaling, and restore epithelial barrier integrity (7). Avoiding supplementation of the diet with refined inulin may be considered, as evidence from mouse models suggests that it can induce abnormal succinate accumulation in the intestinal lumen, thereby contributing to colonic inflammation (8). In parallel, pharmacological inhibition of SUCNR1 using small-molecule antagonists, as well as interventions targeting HIF-1α stabilization, may offer complementary strategies to suppress succinate-driven inflammation (9, 10). Huo et al. demonstrated that the SUCNR1 inhibitor NF-56-EJ40 may suppress glycolysis in intestinal epithelial cells and attenuates Th17-mediated inflammation in a dextran sodium sulfate–induced mouse model of ulcerative colitis. Treatment reduced pro-inflammatory cytokine production, improved epithelial barrier integrity, and alleviated colonic injury, supporting SUCNR1 antagonism as a therapeutic strategy targeting both metabolic and immune pathways (7). Consistently, genetic deletion of SUCNR1 in mice protected against both acute colitis and intestinal fibrosis, while in human fibroblasts derived from Crohn’s disease patients, succinate increased SUCNR1 expression and promoted inflammatory and fibrotic markers that were effectively reversed by SUCNR1 blockade (11). While these approaches are supported by growing mechanistic and translational evidence, well-designed clinical trials will be essential to determine their efficacy and safety in patients with IBD. Conclusion The study conducted by Boronat-Toscano et al. enhances the understanding of how microbiota-driven metabolic dysregulation relates to Crohn’s disease by identifing succinate and Dialister-associated microbial signatures associated as important factors that influence disease activity and the likelihood of postoperative recurrence. These findings support the use of succinate-related biomarkers in future risk assessment and postoperative monitoring strategies. Additionally, they provide a strong biological basis for therapeutic interventions that target succinate metabolism or SUCNR1-mediated signaling. Overall, this study marks a crucial step towards developing metabolically informed, microbiome-based precision medicine for IBD. Author contributions: Fousekis FS wrote the original draft; Lianos GD contributed to conceptualization, writing, reviewing and editing; Katsanos KH and Vlachos K participated in drafting the manuscript; and all authors have read and approved the final version of the manuscript. References 1. Anthamatten L, von Bieberstein PR, Menzi C, Zund JN, Lacroix C, de Wouters T, Leventhal GE. Stratification of human gut microbiomes by succinotype is associated with inflammatory bowel disease status. Microbiome. 2024;12(1):186. PMID: 39350289 PMCID: PMC11441152 DOI: 10.1186/s40168-024-01897-8 2. Wang H, Hu D, Cheng Y, Gao Q, Liu K, Mani NL, Tang AY, Iyer R, Gao B, Zhou Q, Yu Q, Weinberg SE, Zhang X, Cong Y, Dulai PS, Zhang Y, Liu Z, Fang D. Succinate drives gut inflammation by promoting FOXP3 degradation through a molecular switch. Nat Immunol. 2025;26(6):866-80. PMID: 40457062 PMCID: PMC12399925 DOI: 10.1038/s41590-025-02166-y 3. Tannahill GM, Curtis AM, Adamik J, Palsson-McDermott EM, McGettrick AF, Goel G, Frezza C, Bernard NJ, Kelly B, Foley NH, Zheng L, Gardet A, Tong Z, Jany SS, Corr SC, Haneklaus M, Caffrey BE, Pierce K, Walmsley S, Beasley FC, Cummins E, Nizet V, Whyte M, Taylor CT, Lin H, Masters SL, Gottlieb E, Kelly VP, Clish C, Auron PE, Xavier RJ, O'Neill LAJ. Succinate is an inflammatory signal that induces IL-1beta through HIF-1alpha. Nature. 2013;496(7444):238-42. PMID: 23535595 PMCID: PMC4031686 DOI: 10.1038/nature11986 4. Boronat-Toscano A, Queipo-Ortuño MI, Monfort-Ferré D, Suau R, Vañó-Segarra I, Valldosera G, Cepero C, Astiarraga B, Clua-Ferré L, Plaza-Andrade I, Aranega-Martín L, Cabrinety L, Abadia de Barbarà C, Castellano-Castillo D, Moliné A, Caro A, Domènech E, Sánchez-Herrero JF, Benaiges-Fernandez R, Fernández-Veledo S, Vendrell J, Ginés I, Sumoy L, Manyé J, Menacho M, Serena C. Dialister-driven succinate accumulation is associated with disease activity and postoperative recurrence in Crohn's disease. World J Gastroenterol. 2025;31(45):112618. PMID: 41378335 PMCID: PMC12687013 DOI: 10.3748/wjg.v31.i45.112618 5. Han S, Van Treuren W, Fischer CR, Merrill BD, DeFelice BC, Sanchez JM, Higginbottom SK, Guthrie L, Fall LA, Dodd D, Fischbach MA, Sonnenburg JL. A metabolomics pipeline for the mechanistic interrogation of the gut microbiome. Nature. 2021;595(7867):415-20. PMID: 34262212 PMCID: PMC8939302 DOI: 10.1038/s41586-021-03707-9 6. Mitra S, Forster-Fromme K, Damms-Machado A, Scheurenbrand T, Biskup S, Huson DH, Bischoff SC. Analysis of the intestinal microbiota using SOLiD 16S rRNA gene sequencing and SOLiD shotgun sequencing. BMC Genomics. 2013;14 Suppl 5(Suppl 5):S16. PMID: 24564472 PMCID: PMC3852202 DOI: 10.1186/1471-2164-14-S5-S16 7. Huo L, Chen Q, Jia S, Zhang Y, Wang L, Li X, Li Z, Sun B, Shan J, Lin J, Yang L, Sui H. Gut microbiome promotes succinate-induced ulcerative colitis by enhancing glycolysis through SUCNR1/NF-kappaB signaling pathway. Am J Physiol Cell Physiol. 2025;329(2):C440-C54. PMID: 40549551 DOI: 10.1152/ajpcell.00411.2025 8. Tian S, Paudel D, Hao F, Neupane R, Castro R, Patterson AD, Tiwari AK, Prabhu KS, Singh V. Refined fiber inulin promotes inflammation-associated colon tumorigenesis by modulating microbial succinate production. Cancer Rep (Hoboken). 2023;6(11):e1863. PMID: 37489647 PMCID: PMC10644334 DOI: 10.1002/cnr2.1863 9. Haffke M, Fehlmann D, Rummel G, Boivineau J, Duckely M, Gommermann N, Cotesta S, Sirockin F, Freuler F, Littlewood-Evans A, Kaupmann K, Jaakola VP. Structural basis of species-selective antagonist binding to the succinate receptor. Nature. 2019;574(7779):581-5. PMID: 31645725 DOI: 10.1038/s41586-019-1663-8 10. Kim YI, Yi EJ, Kim YD, Lee AR, Chung J, Ha HC, Cho JM, Kim SR, Ko HJ, Cheon JH, Hong YR, Chang SY. Local Stabilization of Hypoxia-Inducible Factor-1alpha Controls Intestinal Inflammation via Enhanced Gut Barrier Function and Immune Regulation. Front Immunol. 2020;11:609689. PMID: 33519819 PMCID: PMC7840603 DOI: 10.3389/fimmu.2020.609689 11. Macias-Ceja DC, Ortiz-Masia D, Salvador P, Gisbert-Ferrandiz L, Hernandez C, Hausmann M, Rogler G, Esplugues JV, Hinojosa J, Alós R; Navarro F, Cosin-Roger J, Calatayud S, Barrachina MD. Succinate receptor mediates intestinal inflammation and fibrosis. Mucosal Immunol. 2019;12(1):178-87. PMID: 30279517 DOI: 10.1038/s41385-018-0087-3 "
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Boronat-Toscano A, Queipo-Ortuño MI, Monfort-Ferré D, Suau R, Vañó-Segarra I, Valldosera G, Cepero C, Astiarraga B, Clua-Ferré L, Plaza-Andrade I, Aranega-Martín L, Cabrinety L, Abadia de Barbarà C, Castellano-Castillo D, Moliné A, Caro A, Domènech E, Sánchez-Herrero JF, Benaiges-Fernandez R, Fernández-Veledo S, Vendrell J, Ginés I, Sumoy L, Manyé J, Menacho M, Serena C. Dialister-driven succinate accumulation is associated with disease activity and postoperative recurrence in Crohn’s disease. World J Gastroenterol 2025; 31(45): 112618
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"This minireview systematically synthesizes the intricate interplay between depression and gastric cancer (GC), incorporating ..."
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"This minireview systematically synthesizes the intricate interplay between depression and gastric cancer (GC), incorporating neuroendocrine, immunological, and psychosocial mechanisms. The authors effectively underscore the bidirectional causality supported by 52 referenced studies, in alignment with the biopsychosocial model. Nonetheless, there are opportunities to enhance methodological rigor and visual communication. Although Figure 1 delineates key components of the bidirectional relationship, its informational density is suboptimal. The figure lacks a hierarchical structuring of pathways (e.g., neuroendocrine versus immune mechanisms) and does not quantify effect sizes (e.g., hazard ratios from cited meta-analyses). It is recommended to incorporate a summary table for comparison. "
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Chen Z, Gong TJ, Zhao L. Bidirectional relationship between depression and the risk and prognosis of gastric cancer. World J Gastrointest Oncol 2025; 17(12): 113272
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"I want to congratulate the authors, Zhang et al, for conducting a study and identifying the predictors of refractory GERD. They have ..."
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"I want to congratulate the authors, Zhang et al, for conducting a study and identifying the predictors of refractory GERD. They have identified the disease duration and anxiety as significant risk factors and at least 90 minutes of moderate-intensity physical activity per week as a protective factor for refractory GERD. One of the important findings in this study is the association of significant Overlap DGBI symptoms (such as dyspepsia, constipation, and diarrhoea) in at least 50% of GERD patients. Since most patients had a duration of illness of more than 4 years, complications of GERD and their comparison between the groups were not noted in this study (a limitation). Although hydrogen impedance is used for diagnosis, the comparison of impedance parameters is not provided. H pylori infection is a protective factor for GERD/Barrett's, which is also a limitation. This study has provided a meaningful conclusion regarding the association between long-term symptoms and refractoriness. "
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Zhang N, Wang Y, Fang SS, Han M, Zheng QW, Zhu YY, Zhang MY, Li JJ, Cui LX, Tian JL, Deng YH, Zhu SL, Ni HM, Zhou L, Zuo GL, Huang TS, Liao Q, Li XQ, Shang YY, Wang YJ, Tian Y, Ge LY, Han HQ, Hu WM, Jiang Y, Li YJ, Mao X, Yang LH, Yao JM, Zheng X, Wang HW, Fang SQ. Clinical characteristics and risk factors of refractory gastroesophageal reflux disease: A multicenter cross-sectional study. World J Gastroenterol 2025; 31(45): 113060
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"The present Letter provides a concise academic response to the article identified by Reader’s code 05354032. The comments focus on ..."
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"The present Letter provides a concise academic response to the article identified by Reader’s code 05354032. The comments focus on several important aspects of the study, including its methodological design, data interpretation, and clinical applicability. The aim is to offer constructive perspectives that may help clarify key issues and support future improvements in related research. "
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Ardila CM, Ángel-Estrada S, González-Arroyave D. Robot-assisted vs conventional lumbar interbody fusion: A systematic review and meta-analysis of perioperative, radiographic, and clinical outcomes. World J Orthop 2025; 16(11): 110276
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"The study title "Comparison of the efficacy of laparoscopic hepatectomy and radiofrequency ablation for small hepatocellular ..."
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"The study title "Comparison of the efficacy of laparoscopic hepatectomy and radiofrequency ablation for small hepatocellular carcinoma: A retrospective study" by Lei et al. aims to compare the long-term survival and perioperative outcomes of Laparoscopic hepatectomy (LH) and radiofrequency ablation (RFA) for small hepatocellular carcinoma (HCC). This retrospective study included 254 patients with small HCC who were collected from Hospital of Chongqing Medical University between December 2022 and March 2025. The results showed that LH was associated with longer operative time, greater blood loss, prolonged recovery, higher costs, and increased complication rates. Consequently, LH, though associated with increased perioperative morbidity, provides superior long-term survival outcomes compared with RFA in patients with small HCC. This study had many limitations such as potential for selection bias and confounding factors that were not controlled for is inherent. The decision to undergo either LH or RFA was made based on clinical judgment and patient-specific factors, which could introduce bias. The sample size was still be insufficient to detect subtle differences in outcomes between the two modalities, especially for subgroups with specific tumor characteristics or comorbidities. Moreover, LH and RFA techniques have evolved over time, and variations in operator experience and institutional protocols could influence outcomes. "
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Lei ZL, Tan ZL, Luo YH, Yang M, Wang JL, Qin Z, Liu YY. Comparison of the efficacy of laparoscopic hepatectomy and radiofrequency ablation for small hepatocellular carcinoma: A retrospective study. World J Gastroenterol 2025; 31(45): 111540
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