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2025-11-26 | Browse: 4 | Download: 0
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801 items Read more >>
1
"First and foremost, I would like to express my sincere gratitude to you and the entire team for your efforts in handling and publishing ..."
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"First and foremost, I would like to express my sincere gratitude to you and the entire team for your efforts in handling and publishing our team's recent article. We appreciate the work involved. However, I would like to take this opportunity to share some feedback regarding our experience with the publication process, which I believe could be improved for future authors. Payment Timeline: We found the requirement to pay the full Article Processing Charge (APC) before the manuscript proceeded to the second round of review to be quite unconventional and rather concerning. Typically, such payments are requested after the final acceptance of a manuscript. This payment-before-final-approval process seems unusual and could understandably cause apprehension among authors. Language Editing Certificate: While we understand the importance of high-quality language standards, we were surprised to be required to obtain a certificate from a professional editing service. Our manuscript had already received an "A-level" readability assessment, indicating it was of good linguistic quality. Requesting a paid certificate under these circumstances felt unnecessary and added an unexpected cost and step to the process. Communication Timeliness: We also experienced some delays in email communication from the handling editor. More prompt responses would have been greatly appreciated, as it would have helped us manage our timelines more effectively. We share this feedback in a constructive spirit, hoping it might be useful for streamlining your processes. Thank you for considering these points. We wish you all the best in your future work. "
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Wang J, Yu XQ, Zhang XG, Song L, Lee J. Short-term spinal cord stimulation for refractory Elsberg syndrome in diabetic neuropathy: A case report. World J Clin Cases 2025; 13(33): 112607
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"We sincerely appreciate the reviewers for their constructive and insightful comments on our manuscript. The feedback has been highly ..."
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"We sincerely appreciate the reviewers for their constructive and insightful comments on our manuscript. The feedback has been highly valuable in improving the scientific clarity, structure, and overall presentation of the work. We carefully revised the manuscript according to all suggestions and provided detailed responses to each point. We believe that the revisions have significantly strengthened the quality and impact of the paper, and we thank the editor and reviewers for their time and professional evaluation. "
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Phadikar SD, Rajendran RL, Muthu S, Gangadaran P, Ahn BC. Exosomal delivery of GrpE-like 1 from synovial mesenchymal stem cells activates PINK1-mediated mitophagy for cartilage repair in osteoarthritis. World J Stem Cells 2025; 17(11): 114306
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"We are extremely satisfied with the entire publishing process. The submission system is notably user-friendly and intuitive. The ..."
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"We are extremely satisfied with the entire publishing process. The submission system is notably user-friendly and intuitive. The comprehensive and constructive nature of the review process was highly beneficial. Specifically, the reviewers' insightful comments enabled us to significantly improve the manuscript. We certainly look forward to submitting and publishing future articles in this journal. "
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Islam MA, Mawya J, Salma U, Abu Kasim NH, Haque N. Unravelling the reversion mechanisms of activated hepatic stellate cell properties by extracellular vesicles from mesenchymal stem cells. World J Stem Cells 2025; 17(11): 111090
4
"The journal’s reputation for excellence is clearly reflected in your team’s dedication, and I truly appreciate the effort put into ..."
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"The journal’s reputation for excellence is clearly reflected in your team’s dedication, and I truly appreciate the effort put into ensuring a smooth and successful publication. Thank you for your hard work and support—it has been a pleasure working with you. I look forward to future opportunities to contribute to your esteemed journal. "
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Miao Y, Zhang R. Effects of Chinese acupuncture on nausea and vomiting after cholecystectomy: A retrospective study. World J Gastrointest Surg 2025; 17(11): 110262
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"The journal’s reputation for excellence is clearly reflected in your team’s dedication, and I truly appreciate the effort put into ..."
[Read more]
"The journal’s reputation for excellence is clearly reflected in your team’s dedication, and I truly appreciate the effort put into ensuring a smooth and successful publication. Thank you for your hard work and support—it has been a pleasure working with you. I look forward to future opportunities to contribute to your esteemed journal. "
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Chen SY, Hu M, Feng ZB, Xu Q, Wang Y. Application of ultrasound-guided localization technology in early gastric cancer surgery and prognostic analysis. World J Gastrointest Surg 2025; 17(11): 109002
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"I am pleased to share my positive experience with your journal, as I greatly value the quality of services across all key areas: the ..."
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"I am pleased to share my positive experience with your journal, as I greatly value the quality of services across all key areas: the intuitive and well-organized forms for online full-text submission, the smooth and efficient article publication workflow, the clear and thorough academic rules and standards made available, and the credible academic misconduct detection report. The sensible publication timeline, stringent editing and publishing protocols, adequate time dedicated to peer review, and well-implemented anonymous peer review system all meet the high standards expected in scholarly publishing. What stands out most is that the peer review feedback has been remarkably useful in enhancing my manuscript, and I firmly believe its comments are fair and objective, rooted entirely in academic rigor and impartial evaluation. "
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Zhao XY, Lu YY, Hong X, Wu XY, Ruan MF. Preventive of deep vein thrombosis in cancer patients after peripherally inserted central catheter catheterization using a diversified comprehensive teaching model. World J Gastrointest Surg 2025; 17(11): 110884
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"It is a great honor to have my work featured in such a highly respected publication, and I am especially thankful for the rigor and ..."
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"It is a great honor to have my work featured in such a highly respected publication, and I am especially thankful for the rigor and professionalism displayed throughout the peer-review and editing process. The valuable feedback received was instrumental in refining the final manuscript. I look forward to continuing to follow the excellent work published and hope to collaborate with your team again in the future. Thank you once more for providing a platform to share this research with the academic community "
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Alvarez M, Rincon J, Ulloa MM, Rincon O, Mejia L, Alvarado A, Pereira A, Bernal M. Osteoporosis and fragility fractures in patients with acromegaly: A two-center cross-sectional study. World J Orthop 2025; 16(11): 110420
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"I would like to convey my genuine appreciation for your journal’s exceptional services across all critical aspects: the well-structured ..."
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"I would like to convey my genuine appreciation for your journal’s exceptional services across all critical aspects: the well-structured forms for the online full-text submission, the seamless article publication process, the clear and comprehensive academic rules and standards provided, and the reliable academic misconduct detection report. The reasonable publication timeframe, rigorous editing and publishing guidelines, appropriate duration allocated to peer review, and robust anonymous peer review mechanism all align with high scholarly expectations. Most notably, the peer review feedback has proven invaluable in refining my manuscript, and I stand by the fairness and objectivity of its comments—grounded purely in academic merit and rigorous evaluation. "
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Zhang Y, Wu J, Yuan Y, Huang YS, Han H. Factors influencing analysis of the efficacy of probiotics combined with enteral nutrition in postoperative patients with colorectal cancer. World J Gastrointest Surg 2025; 17(11): 111973
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"It is a great honor to have my work featured in such a highly respected publication, and I am especially thankful for the rigor and ..."
[Read more]
"It is a great honor to have my work featured in such a highly respected publication, and I am especially thankful for the rigor and professionalism displayed throughout the peer-review and editing process. The valuable feedback received was instrumental in refining the final manuscript. I look forward to continuing to follow the excellent work published and hope to collaborate with your team again in the future. Thank you once more for providing a platform to share this research with the academic community "
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Alvarez M, Quintero E, Rincon O, Llanos C, Reales R, Guzman I. Novel Kruppel-like factor 11 variant of maturity-onset diabetes of the young type 7: A case report. World J Diabetes 2025; 16(11): 111106
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"The review and publication process at the World Journal of Gastrointestinal Surgery was highly professional and efficient. The ..."
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"The review and publication process at the World Journal of Gastrointestinal Surgery was highly professional and efficient. The editorial team provided clear guidance at each stage, and the reviewers’ comments were insightful and constructive, significantly improving the quality of our manuscript. Communication through the F6Publishing system was smooth and transparent, and the timeline from initial review to final acceptance was prompt. We greatly appreciate the dedicated efforts of the editors, reviewers, and production team, and we look forward to continuing to contribute to the journal. "
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Shinji S, Yamada T, Matsuda A, Uehara K, Yokoyama Y, Takahashi G, Iwai T, Miyasaka T, Kanaka S, Hayashi K, Yoshida H. Clinical utility of a novel concentrated enteral formula in patients undergoing colorectal cancer surgery: A randomized controlled trial. World J Gastrointest Surg 2025; 17(11): 112557
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"The pathway to the final publication of the report has been longer than expected, but the process has been handled with great ..."
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"The pathway to the final publication of the report has been longer than expected, but the process has been handled with great professionalism. The reviewers did an excellent job and contributed significantly to improving our work. We are grateful to the editorial team for their efforts, and we have learned a great deal through our interaction with them. "
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Mejuto L, Delgado M, Rabago LR. Magnetic resonance cholangiopancreatography and laparoscopic bile duct exploration should be standard procedures for patients with the ice-breaking sign? World J Gastrointest Surg 2025; 17(11): 111649
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"Overall,.I am satisfied with all.the processes concerning my manuscript. In particular I want to thanks to the reviewers who helped ..."
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"Overall,.I am satisfied with all.the processes concerning my manuscript. In particular I want to thanks to the reviewers who helped in improving the manuscript Also the processes who concerned the editing of the manuscript have.been fine and similarly the figures and tables management. The time needed to publishing on line has been rather long, but this may be ascribed to the large quantity of paper that.have been published this year in Worfd Journal of Transplantation. As editor in chief I am really satisfied of this. "
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Salvadori M, Rosso G. Utility and limitations of the use of donor-derived cell-free DNA in kidney transplantation. World J Transplant 2025; 15(4): 104349
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"We sincerely appreciate the opportunity to publish our work in World Journal of Gastrointestinal Surgery. The entire process, from ..."
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"We sincerely appreciate the opportunity to publish our work in World Journal of Gastrointestinal Surgery. The entire process, from submission to acceptance, was marked by the highly efficient and professional work of your editorial team. We are particularly indebted to the anonymous reviewers for their rigorous scrutiny and constructive feedback, which were instrumental in refining our manuscript and greatly enhanced the final paper. This successful publication is a significant encouragement to our research. We commend your journal for providing an excellent platform for scholarly exchange and look forward to the possibility of future contributions. "
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Sun YW, Liang MJ, Wang XZ, Dong WT, Sun F, Lu XF, Wang F, Liu S, Wang M, Shen XF, Ai SC, Guan WX. Indocyanine green fluorescence imaging in gastric cancer: Clinical efficacy, technical innovations, and future perspectives. World J Gastrointest Surg 2025; 17(11): 109964
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"It was a very positive experience to undergo the peer-review process for our paper in the World Journal of Gastrointestinal Surgery. ..."
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"It was a very positive experience to undergo the peer-review process for our paper in the World Journal of Gastrointestinal Surgery. We consider the reviewers’ contributions to have been timely, enriching, and appropriate. Their input enabled us to achieve a more organized manuscript with enhanced scientific quality. Additionally, the editorial office coordinated the entire process efficiently, ensuring a well-structured workflow. In summary, the review process was constructive and highly professional, resulting in a high-quality final version of the manuscript "
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González Alvarez GE, Ramírez Sánchez C, Martínez Nieto M, Alarcón-Sánchez MA, Varela-Hernández JJ, Lomelí Martínez SM. Glasses-free three-dimensional laparoscopic systems in oncologic surgery: Innovation or equivalence? World J Gastrointest Surg 2025; 17(11): 110718
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"The review process was timely and well-organized, communication with the editorial office was smooth at every stage, and the editors ..."
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"The review process was timely and well-organized, communication with the editorial office was smooth at every stage, and the editors demonstrated a high level of professionalism and responsibility. The entire submission and publication experience was efficient and transparent, and I am very satisfied with the overall process provided by the journal.” "
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Xu PW, Xiao ZH, Yu M, Zhang XY. Advancements in injection materials for submucosal lifting in endoscopic interventions. World J Gastrointest Surg 2025; 17(11): 110323
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"ear Editorial Team, Thank you very much for your message and for the successful publication of our manuscript in the World Journal ..."
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"ear Editorial Team, Thank you very much for your message and for the successful publication of our manuscript in the World Journal of Gastrointestinal Surgery. I sincerely appreciate the efforts of the assistant editor, academic editor, peer reviewers, editorial director, editor-in-chief, language editor, and the production team. Your coordinated work and guidance were essential throughout the entire publication process. I would also like to mention one aspect of the experience that may help improve future workflows. We noticed a significant discrepancy in the language-editing evaluations from the reviewers—one reviewer assigned grade A, while another assigned grade C. To address this concern, we provided an official language-editing certificate confirming the linguistic quality of the manuscript. This inconsistency made the editorial process somewhat challenging. In addition, the overall review timeline was relatively long, and streamlining this step might contribute to an even more efficient publication process in the future. Despite these points, we are grateful for the professionalism and dedication shown by all members of the editorial team. Thank you once again for your support and for the opportunity to publish our work in your journal. "
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Costea NC, Vesa S, Toma M, Pojoga C, Seicean A. Fluid therapy strategies in acute pancreatitis: Randomized controlled trial comparing dextran and Ringer’s lactate. World J Gastrointest Surg 2025; 17(11): 109869
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"Overall, this has been a very pleasant experience of submitting our manuscript. The editors and reviewers conducted a thorough ..."
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"Overall, this has been a very pleasant experience of submitting our manuscript. The editors and reviewers conducted a thorough evaluation of our paper and provided constructive feedback for revision. Their efforts have significantly improved the content and quality of our article. For this, we would like to express our sincere gratitude. "
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Li HL, Zhang HR, Wu Y, He KQ, Chen TJ, Wang J. Anal sphincter reconstruction for fecal incontinence: Techniques, outcomes, and future directions. World J Gastrointest Surg 2025; 17(11): 112868
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"I would like to express my sincere gratitude to the editorial board for offering me the opportunity to evaluate high-quality papers ..."
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"I would like to express my sincere gratitude to the editorial board for offering me the opportunity to evaluate high-quality papers in the metabolism-related field. The entire process was smooth and satisfying: the comments from the reviewers were highly professional, and the editors were extremely diligent and responsible, demonstrating a rigorous scientific attitude. It was an excellent submission experience. "
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Cui X, Liang Z. Concerns regarding lipid metabolism, immune regulation, and methodology in a study on esophageal cancer lymph node metastasis. World J Gastrointest Surg 2025; 17(11): 112124
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"Everything was excellent. The editorial office services and prompt response to requests were enthusiastic. Also, the peer review ..."
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"Everything was excellent. The editorial office services and prompt response to requests were enthusiastic. Also, the peer review process could be characterized by great satisfaction. Thank you very much for your cooperation. I am looking forward to continuing this scientific activity. I hope to continue with the best impressions. Best regards from Thessaloniki, Greece. "
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Mouratidou C, Pavlidis ET, Katsanos G, Kotoulas SC, Papaioannou M, Tsoulfas G, Apostolopoulou E, Brellou GD, Galanis IN, Pavlidis TE. Protective effects of treprostinil and ischemic preconditioning on hepatic ischemia-reperfusion injury and biomarkers in experimental studies in rats. World J Gastrointest Surg 2025; 17(11): 110864
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"Manuscript review process was smooth. Proof editing process was also smooth. Only comment that I have is that there is a slightly ..."
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"Manuscript review process was smooth. Proof editing process was also smooth. Only comment that I have is that there is a slightly long time between the time of manuscript acceptance and final publishing of the manuscript. Otherwise, I feel that the editors have been helpful throughout the manuscript publication process. "
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Chan KS, Ng P, Tan L, Soh REJ, Tan BT, Ong YJ, Chong JL, Mantoo SK, Lee YZ, Tan KY, Lee DJK. Postoperative outcomes following prehabilitation vs no prehabilitation in elective colorectal surgery: A 2:1 propensity score-matched analysis. World J Gastrointest Surg 2025; 17(11): 108345
20029 items Read more >>
1
"This study proposes that the tumor-suppressive functions of these proteases are contingent upon the stage of cancer progression or ..."
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"This study proposes that the tumor-suppressive functions of these proteases are contingent upon the stage of cancer progression or metastatic conditions, and may be activated or suppressed in response to cues from the tumor microenvironment. The proposition that the functional role of tumors—either promoting or inhibiting cancer—can be dynamically regulated by the tumor microenvironment is a noteworthy conceptual advancement. Indeed, cancer is increasingly recognized as a complex pathological ecosystem. Within this framework, genes and mutations are not primary causal drivers of carcinogenesis—as posited by the prevailing somatic mutation theory—but rather represent one of many events occurring throughout tumor evolution. A more comprehensive understanding therefore requires the integration of genetic and mutational dynamics within broader ecological and evolutionary contexts (https://pubmed.ncbi.nlm.nih.gov/40443342/)."
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Palacios Serrato EG, Medina-Abreu KH, Oropeza-Martínez E, Jacinto-Alemán LF, Macías-Silva M, Tecalco-Cruz AC. ADAMTS-8 and kallikrein-related peptidases 10 and 5 proteases also have a tumor suppression role. World J Clin Oncol 2025; 16(11): 110202
2
"• This is very interesting paper about pancreatic cyst. Pancreatic cysts are diagnosed through imaging tests like CT, MRI, and ..."
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"• This is very interesting paper about pancreatic cyst. Pancreatic cysts are diagnosed through imaging tests like CT, MRI, and endoscopic ultrasound (EUS). These tests help characterize the cyst's size, structure, and relationship to the pancreas. An EUS can also be used to collect fluid or tissue samples for lab analysis to check for cancer cells, while other factors like symptoms, patient history, and risk factors are also considered to make a final diagnosis. Fluid and tissue analysis: If a sample is collected through EUS-FNA, the fluid is analyzed for specific markers like carcinoembryonic antigen (CEA), which can help identify cancer. The diagnostic process involves a combination of medical history review, various imaging tests, and sometimes fluid analysis/biopsy to determine the cyst's type and its potential for malignancy.
"
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Shumka N, Karagyozov PI. Cystic tumors of the pancreas: Current perspectives on diagnosis and management. World J Gastroenterol 2025; 31(43): 111393
3
"The article is well written and well conducted.
I particularly appreciated the discussion, which is rich and full of interesting ..."
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"The article is well written and well conducted.
I particularly appreciated the discussion, which is rich and full of interesting comments.
Unfortunately, the study is retrospective. The addition of other parameters, such as the precence of left ventricular noncompaction and serum electrolyte values, would likely have further differentiated the two populations studied."
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Kaddoura R, Al-Tamimi H, Pieles GE. Racial disparities in electrical and structural cardiac adaptation among adolescent athletes: A systematic review and meta-analysis. World J Cardiol 2025; 17(11): 107835
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" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..."
[Read more]
" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Park YE. Gastric Crohn’s disease presenting as a subepithelial tumor: A case report. World J Clin Cases 2025; 13(33): 113312
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" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..."
[Read more]
" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Bergeron E, Gologan A. Abdominal compartment syndrome with colonic hypoganglionosis and massive colonic distension in a young adult: A case report. World J Clin Cases 2025; 13(33): 112684
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"1. Ethics
It is a review article thus ethics approval form is not required
2. Methods
As a narrative/invited review, the “methods” ..."
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"1. Ethics
It is a review article thus ethics approval form is not required
2. Methods
As a narrative/invited review, the “methods” section is not a detailed primary experimental protocol. The paper describes construction methods of gastric organoids, modeling steps, mechanisms, limitations and future directions.
The methods are adequate in describing the topic and background rather than reporting new experimental workflows.
3. Results
The results are summary of published work rather than original data. The authors summaries how gastric organoids can model atrophic gastritis → intestinal metaplasia → dysplasia → gastric cancer, and discuss mechanisms and propose that gastric organoids are a “promising model” for the inflammation-cancer transition.
4. Figures and Tables
Figures shows the multiple schematic figures. Annotation/Quality of the figures is good and are schematic exhibiting the appropriateness for this study. The legends appear clear; axes/labels in the schematics are present. The paper has well-constructed and expressive figures and tables.
5. Biostatistics
This is a review paper, there is no new statistical analyses/biostatistical tables of primary data are needed.
6. References
Lis of references is current, appropriate and is reasonable in number (> 100)
7. Language
The language is clear, rationally concise, and generally well-written.
"
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Liu C, Wu CH, Jia YB, Qiu JX, Li XY, Ling JH. Gastric organoids: A promising model for studying “inflammation-cancer” transition in atrophic gastritis. World J Clin Oncol 2025; 16(11): 110453
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"It was with pleasure that I tracked the article quality of the following manuscript. Please see my comments below:
1 Ethics: Not ..."
[Read more]
"It was with pleasure that I tracked the article quality of the following manuscript. Please see my comments below:
1 Ethics: Not applicable given manuscript type
2 Methods: Not applicable given manuscript type
3 Results: Not applicable given manuscript type
4 Figures and tables: The figures add to the readability of the manuscript
5 Biostatistics: Not applicable given manuscript type
6 References: The references are appropriate/up-to-date
7 Language: This is a concise/well written editorial
8 Caveats or drawbacks: N/A "
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Zerem E, Zerem D, Vila Š, Bajgorić S. Ascites in acute pancreatitis: A window into disease severity. World J Gastroenterol 2025; 31(43): 112797
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"“Pyroptosis” is a term composed of the union of two separate ancient Greek words, namely “Πυρ” (Fire) and “Πτώσις” (fall), which ..."
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"“Pyroptosis” is a term composed of the union of two separate ancient Greek words, namely “Πυρ” (Fire) and “Πτώσις” (fall), which together mean “fall of the fire” (reduction of inflammation). It is a lytic mechanism of programmed cell death that involves cleavage of proteins in the gasdermin D family. Its effects are mediated through nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3)/caspase-1 classical and caspase-4/5/11. The inflammatory process mediated by this mechanism appears to play a central role in the development and pathogenesis of IBD by destroying the intestinal epithelial barrier, leading to excessive inflammation and worsening the disease progression.
Targeting pyroptosis is a promising therapeutic approach for IBD. Recent data support the notion that inhibitors of inflammasomes, such as small-molecule biological agents, other biological agents, and drugs that specifically target NLRP3, caspases, or GSDMD, suppress inflammasome activation and inhibit membrane pore formation. However, the precise regulatory mechanisms and therapeutic effect of pharmacological targeting of inflammasomes in IBD are not fully understood.
Research on the specificity of pharmaceutical agents that may prove effective in treating the disease, the extent of drug side effects, and the potential for combination with other active pharmaceutical agents is a key goal for the near future.
"
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Dong WW, Liu T, He LX, He WT. Targeting pyroptosis in inflammatory bowel disease: A potentially effective therapeutic approach. World J Gastroenterol 2025; 31(43): 111358
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"This letter to the Editor just agrees with the authors of the original paper that BMI is associated with worse outcome in patients ..."
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"This letter to the Editor just agrees with the authors of the original paper that BMI is associated with worse outcome in patients with acute liver injury. In this regard, all "scientific" information descries only "associations" with BMI and organ failure. However no studies indicate possible causes so science can advance towards possible treatments beyond weight loss."
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Kanda T, Sasaki-Tanaka R, Kamimura H, Terai S. Is higher body mass index correlated with worse clinical outcomes in acute liver failure? World J Clin Cases 2025; 13(32): 113514
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"A concise, comprehensive, complex and well-structured manuscript. There are no grammatical/spelling errors throughout the manuscript ..."
[Read more]
"A concise, comprehensive, complex and well-structured manuscript. There are no grammatical/spelling errors throughout the manuscript and the topic debated is of a great interest due to the fact that AI technologies have a real potential to revolutionize liver lesion assessment in association with CEUS. Indeed, in order to obtain a valid implementation in clinical practice of AI technologies combined with CEUS, we need more large-scale prospective studies in the near future.
"
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Ciocalteu A, Urhut CM, Streba CT, Kamal A, Mamuleanu M, Sandulescu LD. Artificial intelligence in contrast enhanced ultrasound: A new era for liver lesion assessment. World J Gastroenterol 2025; 31(42): 112196
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"1 Ethics: Not provided
2 Methods: The experimental method is effective and can be repeated by fellow researchers
3 Results ..."
[Read more]
"1 Ethics: Not provided
2 Methods: The experimental method is effective and can be repeated by fellow researchers
3 Results The theory is validated
4 No figures or tables provided
5 Biostatistics: Not needed
6 References: The author scientifically and reasonably cite the latest references
7 Language: The language in article correctly, clearly and concisely expresses the information
"
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Sameer M, Muthu S, Vadranapu S. Prophylactic fixation in elderly fractures: Preventive breakthrough or unnecessary intervention? World J Orthop 2025; 16(11): 109855
12
"In the recent years,the relationship between intestinal flora disorders and various diseasess,especially IBD,has become clear, and ..."
[Read more]
"In the recent years,the relationship between intestinal flora disorders and various diseasess,especially IBD,has become clear, and fecal transplantation , which aims to improve dysbiosis, has attracted attention.This study also reports on fecal transplantation for the purpose of correcting intestinal flora disorders in IBD,and further research and clinical application are expected in the furture."
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Zheng L, Duan SL, Wang K. Research progress concerning the involvement of the intestinal microbiota in the occurrence and development of inflammatory bowel disease. World J Gastroenterol 2025; 31(42): 113170
13
"It was with pleasure that I reviewed the article quality of the following manuscript. Please see my comments below:
1 Ethics: ..."
[Read more]
"It was with pleasure that I reviewed the article quality of the following manuscript. Please see my comments below:
1 Ethics: Not applicable given manuscript type
2 Methods: Not applicable given manuscript type
3 Results: Not applicable given manuscript type
4 Figures and tables: The tables add to the readability of the manuscript
5 Biostatistics: Not applicable given manuscript type
6 References: References are appropriate/up to date
7 Language: This is a concise/well written manuscript
8 Caveats or drawbacks: None "
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Wang XY, An F, Wang BJ, Han WW. Hydrogen peroxide pathway in ulcerative colitis: Promises and challenges in translating novel pathogenesis to clinical practice. World J Gastroenterol 2025; 31(42): 112566
14
"Overall Assessment
1. The letter clearly addresses the association between BMI and clinical outcomes in ALF, which is clinically ..."
[Read more]
"Overall Assessment
1. The letter clearly addresses the association between BMI and clinical outcomes in ALF, which is clinically relevant.
2. The format follows standard Letter to the Editor conventions, making it easy to read.
3. The discussion is well-supported by Krishnan et al.’s recent study and previous reports (Kanda et al., Rutherford et al.), with accurate citations.
Strengths
1. Highlights a growing concern—obesity and its impact on ALF outcomes.
2. Includes Japanese and U.S. data, showing differences in etiology (acetaminophen vs. non-acetaminophen causes).
3. Emphasizes vigilance for renal failure and hepatic encephalopathy in obese ALF patients.
"
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Kanda T, Sasaki-Tanaka R, Kamimura H, Terai S. Is higher body mass index correlated with worse clinical outcomes in acute liver failure? World J Clin Cases 2025; 13(32): 113514
15
"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..."
[Read more]
"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Kim N, Lee H, Park D. Challenging diagnosis of groove pancreatitis with severe gastric outlet obstruction: A case report. World J Clin Cases 2025; 13(32): 111796
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"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..."
[Read more]
"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Aisikaer A, Sun MM, Shen J. Positron emission tomography/computed tomography in risk-factor-negative young female with malignant pleural mesothelioma: A case report and review of literature. World J Clin Cases 2025; 13(32): 110897
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"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..."
[Read more]
"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Liu KT, Lee MH, Lin CH, Tsou YK, Sung KF, Wang SF, Wu CH, Liu NJ. Acute cholangitis due to common bile duct stones: Clinical outcomes in patients with and without concurrent acute pancreatitis. World J Clin Cases 2025; 13(32): 110553
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"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..."
[Read more]
"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Noh BG, Seo HI, Park YM, Oh MH, Song SB. Clinicopathologic differences before and after elective laparoscopic cholecystectomy according to obesity. World J Clin Cases 2025; 13(32): 110391
19
"Has authors used low threshold for BMI in this study.This needs attention and could be bias.To apply this , international definition ..."
[Read more]
"Has authors used low threshold for BMI in this study.This needs attention and could be bias.To apply this , international definition for obesity needs to be included.The study is read by clinicians all over world ans using nonstandardised definition needs to reconsider.
sing a standardized 3-port LC technique.
Using 3 port instead of 4 port in obesity raises alarm over safety keepi in view ergonomics
Intraoperative bile leak in your series seems to be heroic by using 3 port lap chole
"
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Noh BG, Seo HI, Park YM, Oh MH, Song SB. Clinicopathologic differences before and after elective laparoscopic cholecystectomy according to obesity. World J Clin Cases 2025; 13(32): 110391
20
"This case report is highlighting low threshold of Malignancy in groove pancreatitis.A meticolous clinical approach is refeclting in ..."
[Read more]
"This case report is highlighting low threshold of Malignancy in groove pancreatitis.A meticolous clinical approach is refeclting in this case.Imaging is well giving learning .
Introduction is well evidence based.Case presentation is excellent.Discussion is robust with well coverage of latest updates in literaure.References are latest one
Overall, a case report giving good "Message to take home "
"
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Kim N, Lee H, Park D. Challenging diagnosis of groove pancreatitis with severe gastric outlet obstruction: A case report. World J Clin Cases 2025; 13(32): 111796
15852 items Read more >>
Peer-Reviewers and Manuscript Statistics
- Editorial board members
- 2264
- Peer-reviewers
- 34831
- Manuscripts received today
- 11
- Manuscript reviews today
- 27
- Unhandled manuscripts today
- 150
- Active peer-reviewers today
- 3063
- Reviewer acceptance today
- 42
- Reviewer refusals today
- 59
- Total accepted manuscripts
- 38765
- Total rejected manuscripts
- 43802
- Total peer-reviewers
- 4522985
- Total submissions
- 36804
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1
"The authors present a clinically important case highlighting the coexistence of mixed connective tissue disease (MCTD) and ..."
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"The authors present a clinically important case highlighting the coexistence of mixed connective tissue disease (MCTD) and tuberculosis (TB), a scenario that poses substantial diagnostic challenges in TB-endemic regions. The manuscript is well structured and clearly describes the sequence of clinical events, laboratory workup, and therapeutic decisions. The discussion appropriately emphasizes the overlap between autoimmune manifestations and infectious etiologies, particularly when both present with pulmonary involvement. From an academic standpoint, the case is relevant and contributes meaningfully to the limited global literature examining MCTD–TB coexistence. The authors successfully integrate immunological findings with epidemiological considerations, underscoring the need for high clinical suspicion and comprehensive autoimmune evaluation in complex presentations. The reference list is current and well selected, drawing from both rheumatology and infectious disease literature. The language is generally clear and understandable, although a few sections may benefit from stylistic tightening to improve flow, particularly in the discussion where multiple concepts are presented in close succession. Minor grammatical refinements could enhance readability. The inclusion of comprehensive tables and immunological profiles strengthens the diagnostic clarity of the case. For future research and case documentation, the authors may consider: 1. Providing a more detailed longitudinal follow-up, especially regarding TB status, autoimmune markers, and treatment tapering, as long-term outcomes for MCTD-TB coexistence are not well described in the literature. 2. Elaborating on radiologic findings, given the central role of imaging in differentiating pulmonary TB from autoimmune lung involvement. 3. Discussing possible immunopathological links between chronic infections and autoimmune flare, which could enrich the mechanistic understanding of such overlap syndromes. 4. Addressing medication safety monitoring, particularly concerning hepatotoxicity in the context of ATT combined with corticosteroids and hydroxychloroquine. Overall, this is a valuable clinical contribution that highlights key diagnostic considerations in resource-limited, TB-endemic settings. The manuscript is academically sound, clinically relevant, and will be informative for physicians managing complex autoimmune presentations. "
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Sial F, Basit A, Ghafoor N, Sial W, Basil AM. Mixed connective tissue disease and tuberculosis coexistence as a diagnostic dilemma: A case report. World J Clin Cases 2025; 13(33): 109866
2
"The review by Nian et al. offers a thorough and thoughtfully articulated overview of current insights into Osteopontin (OPN)–mediated ..."
[Read more]
"The review by Nian et al. offers a thorough and thoughtfully articulated overview of current insights into Osteopontin (OPN)–mediated PI3K/AKT signaling and its pivotal influence on gastrointestinal cancer progression, metastatic behavior, and therapeutic resistance. The authors skillfully synthesize mechanistic and translational findings, underscoring how OPN-driven activation of the PI3K/AKT pathway promotes epithelial–mesenchymal transition, metabolic adaptation, immune escape, and chemoresistance. Their discussion of OPN splice variants, tumor microenvironment interactions, and biomarker-informed therapeutic strategies provides meaningful guidance for advancing precision oncology. A major strength of the review is its emphasis on the inherent complexity and compensatory nature of OPN–PI3K/AKT signaling, which helps explain the challenges associated with single-agent therapeutic approaches. The recommendation to pursue combination strategies—such as pairing PI3K/AKT inhibitors with immune checkpoint blockade or OPN-targeted antibodies—is timely and supported by accumulating preclinical data. Furthermore, the manuscript’s focus on PIK3CA mutation subsets and OPN expression as potential predictive biomarkers may enable more refined patient stratification in future clinical trials. Despite these promising avenues, clinical translation remains constrained. Current trials evaluating PI3K/AKT inhibitors in gastrointestinal malignancies have yielded limited efficacy and notable toxicity, highlighting the need for more rigorous biomarker-driven study designs. Although the review acknowledges these issues, a deeper appraisal of the reasons underlying clinical shortcomings—and the specific contribution of OPN signaling to these obstacles—would further strengthen its clinical impact. In sum, this review provides a valuable contribution by elucidating the diverse oncogenic roles of OPN and outlining strategic paths toward overcoming therapeutic resistance. Continued research into isoform-specific activity, tumor microenvironmental dynamics, and rational combinatorial regimens will be crucial for realizing the therapeutic potential of targeting the OPN–PI3K/AKT axis in gastrointestinal cancers. "
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Nian H, Bai Y, Wang HY, Yu H, Zhang ZL, Shi RH, Zhang S, Wu YB, Zhou DH, Du QC. Targeting the Osteopontin-regulated PI3K/AKT signaling pathway: A molecular approach to overcome drug resistance and metastasis in gastrointestinal tumors. World J Gastrointest Oncol 2025; 17(11): 109923
3
"This article presents an interesting retrospective study involving a substantial cohort of patients, highlighting the role of total ..."
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"This article presents an interesting retrospective study involving a substantial cohort of patients, highlighting the role of total neoadjuvant therapy (TNT), specifically the RAPIDO protocol, compared to conventional long-course chemoradiotherapy (LCCRT) in the management of locally advanced rectal cancer (LARC). The study focuses on early surgical outcomes, a topic of significant clinical relevance. The cornerstone of LARC treatment remains optimal surgical resection via total mesorectal excision (TME). To reduce locoregional failure, preoperative concurrent chemoradiotherapy has long been the standard of care. However, as noted in the article and supported by prior evidence (e.g., Fokas et al.), the efficacy of this approach is primarily confined to local control, while distant metastases continue to be a major cause of treatment failure and compromised survival. The intensification of neoadjuvant therapy through TNT addresses this limitation by achieving early systemic control, significant tumor downstaging, and higher rates of pathological complete response, all without compromising early surgical outcomes compared to LCCRT, as demonstrated in this study. Moreover, the authors report that TNT is associated with a shorter total stoma duration and a lower permanent stoma rate, which are meaningful benefits for patients' quality of life. Recent landmark trials, such as RAPIDO and PRODIGE 23, have provided robust evidence supporting the use of TNT, showing improved pathological complete response, better treatment compliance, and reduced distant metastases compared to LCCRT. This study adds valuable real-world data to the growing body of literature affirming the safety and feasibility of TNT from a surgical perspective. We commend the authors for their contribution and agree that further prospective studies with longer follow-up are warranted to evaluate long-term oncological outcomes. (By Prof Sanaa El Majjaoui and Pr Nabil Ismaili) "
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Jabbar SAA, Choo ALE, Wong NW, Ngu JCY, Teo NZ. Comparing early surgical outcomes between total neoadjuvant therapy and standard long course chemoradiotherapy for rectal cancer. World J Gastrointest Oncol 2025; 17(11): 111250
4
"This minireview describes the important role of 0steopontin (OPN)-regulated the phosphatidylinositol 3-kinase (PI3K)/protein kinase ..."
[Read more]
"This minireview describes the important role of 0steopontin (OPN)-regulated the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) signaling pathway in gastrointestinal tumor proliferation, metastasis, chemoresistance, and immune evasion. Targeting osteopontin-regulated PI3K/AKT signaling pathway with PI3K/AKT inhibitors or OPN neutralizing antibodies may reverse drug resistance and suppress metastasis. Further research should be needed to find combination therapies which have the potential to provide more effective anti-tumor activity towards refractory cancers. "
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Nian H, Bai Y, Wang HY, Yu H, Zhang ZL, Shi RH, Zhang S, Wu YB, Zhou DH, Du QC. Targeting the Osteopontin-regulated PI3K/AKT signaling pathway: A molecular approach to overcome drug resistance and metastasis in gastrointestinal tumors. World J Gastrointest Oncol 2025; 17(11): 109923
5
"I want to congratulate the authors for conducting this excellent study on the impact of PAD in PEP. This study has demonstrated that ..."
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"I want to congratulate the authors for conducting this excellent study on the impact of PAD in PEP. This study has demonstrated that PAD, particularly Type B, has a Significant risk of PEP. This subgroup analysis of PAD is important for advancing efforts to prevent PEP. This study included predominantly older patients, where the prevalence of PAD is higher. Whether the presence of only PAD increases the risk of pancreatitis is still difficult to interpret. As PAD increases the difficulty of CBD cannulation, requiring advanced cannulation techniques which itself may increase the risk of PEP, furthermore indication of ERCP is also analysed in both groups "
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Shu J, Liao YS, Zhang YJ, Zhou WL, Zhang H. Impact of periampullary diverticulum on the incidence of post-endoscopic retrograde cholangiography pancreatitis. World J Gastrointest Endosc 2025; 17(11): 111243
6
"The study by Li Lin et al., “Early vs conventional initiation of adjuvant chemotherapy in advanced gastric cancer: A ..."
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"The study by Li Lin et al., “Early vs conventional initiation of adjuvant chemotherapy in advanced gastric cancer: A propensity-matched outcomes study,” addresses a clinically relevant question; however, several issues limit the strength and applicability of its conclusions. First, the analysis does not demonstrate any clear advantage of early versus conventional initiation of adjuvant chemotherapy in terms of either overall survival or disease-free survival. A possible benefit is suggested with respect to the rate of peritoneal recurrence, but this signal is difficult to interpret in the absence of any comparison with currently available intraperitoneal treatment strategies. Moreover, the study does not provide robust selection criteria to clearly identify which patients might be optimal candidates for an earlier initiation of adjuvant therapy. Given the well-known short-term physiological impact of gastrectomy, there is a concrete risk that patients starting chemotherapy very early after surgery may actually receive a suboptimal treatment—most notably through dose reductions—precisely in the first cycles, when dose intensity may be most critical. Finally, the heterogeneity of the adjuvant chemotherapy regimens, which persists even after propensity score matching, further complicates interpretation of the results and limits the ability to draw firm conclusions regarding the true effect of treatment timing per se. "
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Lin L, Zhang P, Wang YY, Cai YF, Wen LB, Chen WP, Xiao YF, Li ZK, Liu GY. Early vs conventional initiation of adjuvant chemotherapy in advanced gastric cancer: A propensity-matched outcomes study. World J Gastroenterol 2025; 31(42): 110069
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"Long-term prognosis of HBV-cirrhosis hepatocellular carcinoma recurrence and mortality rates post-treatment with antivirals TDF, TAF, ..."
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"Long-term prognosis of HBV-cirrhosis hepatocellular carcinoma recurrence and mortality rates post-treatment with antivirals TDF, TAF, ETV and curative radiofrequency ablation is still controversial Dina Johar* Department of Biochemistry and Nutrition, Faculty of Women for Arts, Sciences and Education, Ain Shams University, Heliopolis, Cairo, Egypt *Dina Johar, PhD Department of Biochemistry and Nutrition Faculty of Women for Arts, Sciences, and Education Ain Shams University, Cairo, Egypt Phone:+2 01060782045 Email: dinajohar@gu.edu.eg • To whom correspondence should be addressed Abstract The efficiency of antiviral agents for hepatitis B cirrhosis-related hepatocellular carcinoma (HCC) is still an important clinical challenge with high recurrence rates. In this commentary, we focus on recent findings from Xu et al. We highlight the potential benefit of studying HBV genotypes and subgenotypes as possible mechanisms behind different responses to antivirals. Mechanisms of viral reactivation that parallel HCC recurrence remain uncovered. The commentary is a significant step forward in understanding the nuanced approach to managing HCC recurrence and mortality rate in HBV-cirrhosis patients, offering valuable insights for clinical decision-making. Keywords HBV-related HCC, TDF, TAF, ETV, recurrence, mortality Core Tip A similar virological response to TDF, TAF, and ETV treatment in the first 6-12 months may require further investigation to understand early treatment dynamics. Understanding how HBV genotypes and subgenotypes influence chronic active HBV infection is crucial. Investigating potential molecular mechanisms that explain recurrence rate differences helps develop predictive models for individualized treatment selection. Background The paper entitled “Effect of antiviral therapy on 3-year recurrence and prognosis of hepatocellular carcinoma after curative radiofrequency ablation” by Xu et al. (1) is a robust retrospective cohort study that comprehensively evaluates long-term prognostic effects of advanced nucleos(t)ide analogs (NAs): ETV, TDF, and TAF on HBV-cirrhosis HCC patients post-RFA outcomes. The study identified four independent predictors of post-RFA HCC recurrence. The study findings recommend TDF or TAF as preferred antiviral agents for the long-term management of such patients. The three antiviral agents had a similar impact on the three-year mortality rate. The study used a substantial sample size (n=319) with a follow-up period of 144 weeks, across multiple time points (6, 12, 24, 36 months), although the sample sizes in the TDF (n=76) and TAF (n=52) groups are relatively small. Two of the major determinants of the outcome of chronic HBV infection are the HBV genotypes and subgenotypes. While Xu et al. adhered to established diagnostic guidelines, there are at least ten different confirmed HBV genotypes (A-J). There is limited knowledge about how different genotypes and subgenotypes of HBV affect the risk of HCC recurrence in patients with HBV-cirrhosis related HCC. The best way to find out is through long-term, population-based studies. These studies should compare people with different genotypes and follow them over time. For example, there is a substantial homogeneity of HBV subtypes found in Egypt, a country with a comparably high HBV-cirrhosis-related HCC, mostly genotype D, subgenotype D3, hepatitis B surface antigen (HBsAg) subtype ayw2, with a prevalence of the Major Hydrophilic Region (MHR) mutations (2). Genotype D is related to more advanced liver disease, i.e., HCC, than other genotypes (3) and is an independent risk for Fulminant Hepatitis (FH) (4). Whether new classes of drugs are needed to manage chronic HBV, whether a cure is possible, or even necessary, has not been addressed. The goal of new therapies for chronic hepatitis B should be to achieve a virological cure. Current NAs can slow down HBV replication and help improve liver damage. However, they rarely fully clear chronic HBV infections. There is an urgent need for new drugs and more effective strategies to combat the virus, which eventually will help get rid of the cancer. Still, more research is needed to find clear links between specific genotypes and risks like cirrhosis or HCC. Some research has been carried out in areas such as Asia and Alaska, but many genotypes, including A1 and D, have not been studied in long-term, prospective research. Data is missing for some genotypes and subgenotypes, such as A3, E, F4, and H, regarding their impact on health. Collaboration between multiple institutions from different countries enhances the strength of these studies. Retrospective and prospective studies examined serum HBV DNA levels, liver function, complication rates, and hospital stay duration (5, 6). A study looked at whether high-dose TDF therapy can stop HBV-related HCC recurrence. They designed a study where everyone received the same treatment, with no comparison group. The goal was to determine if using high-dose TDF is practical in real-world settings. They enrolled 10 patients in September 2015 and monitored their progress for three months or until they had to discontinue treatment early. They found that high doses of TDF, up to five times the recommended amount, are poorly tolerated by many patients. These doses also do not effectively stop HBV from replicating as HCC progresses (7). In 2018, a study looked at 607 patients with HBV-related HCC who had surgery or RFA. They divided them into three groups based on their antiviral drugs. The first group, with 261 patients, did not get antiviral treatment. The second group, with 90 patients, received low-strength NAs. The last group, with 256 patients, was treated with high-strength NAs. The main goal was to see how long patients stayed free of cancer recurrence. Patients on ETV and TDF had fewer recurrences than those on other antivirals (8). Another study followed 1,695 patients who had surgery for HBV-related HCC at Korea’s Barcelona Clinic Liver Cancer stage 0 or A between 2010 and 2018. Of these, 813 patients received ETV while 882 took TDF. The study compared cancer recurrence and overall survival between the two groups, using statistical methods to match patients’ backgrounds and adjust for other confounding factors. The analysis started from the day of their liver surgery. Results showed that patients on TDF had a notably lower chance of their HCC recurrence and survived longer overall than those on ETV (9). Between 2013 and 2017, three hospitals enrolled patients with HBV-related HCC who had surgery or ablation as their first treatment. A 421 patients had part of their liver removed, and 305 received RFA. All of these patients started antiviral medication using either ETV or TDF. The study examined HCC recurrence and mortality rates. Researchers adjusted for factors such as HBV DNA levels, tumour characteristics, and patient demographics. The results showed no significant difference in cancer recurrence or death rates between patients treated with ETV and TDF (10). Patients with HCC who go beyond the Milan criteria tend to have a high chance of HCC recurrence post-surgery. When comparing treatments, TDF significantly reduces the risk of HCC recurrence more than ETV therapy (11). Using propensity score matching from the date of liver resection for HCC, TDF showed better overall survival. It also offered stronger protection of liver function. However, in another study, there was no difference in the rate of HCC recurrence between TDF and ETV treatments (12). Other research shows that TDF works better than ETV for eliminating hepatitis B symptoms after RFA treatment. It helps reduce serum HBV DNA levels and improves the albumin-bilirubin (ALBI) grade more effectively (13) (14). A study in 2024 looked at how TDF and ETV affect long-term health in patients with HCC, fatty liver disease, and HBV. The researchers analyzed patient data using a multivariate Cox proportional hazards model and applied a propensity score matching method. They then compared survival outcomes with Kaplan-Meier survival curves. The results showed that TDF helped improve long-term prognosis for patients (15). The latter discovery was confirmed in 2025 in patients with high HBsAg levels after they had their liver removed (16). A study looked back over ten years, finishing in 2025. It included 1,396 patients with HBV-related cirrhotic HCC who had surgery. The patients were divided into two groups: those who took antiviral medicine and those who did not. The research focused on HCC recurrence, taking into account when the antiviral treatment was started, how well the virus was kept under control, and the levels of HBV DNA. Recurrences were labelled as early if they occurred within two years and late if they occurred after that. The study found that long-term antiviral therapy helped prevent late recurrence after surgery, regardless of whether it was started pre- or post-operation. Patients who responded well to the virus treatment saw the biggest benefit (17). Given such controversial results, in Xu et al. study, being a single-center study, there is potential for selection bias inherent in the retrospective study design. The uneven baseline characteristics across treatment groups, potential need for larger sample size to validate findings, and limited exploration of potential mechanisms are behind the differential recurrence rates achieved with TDF, TAF versus ETV, or even behind the similar impact that the three NAs had on the three-year mortality rate. The study will benefit from extending the follow-up period to provide more comprehensive long-term insights. Considering propensity score matching to reduce potential selection bias. Expanding the research scope through multi-center collaborative study enhances external validity and generalizability. Exploring potential interaction effects between NAs and the molecular mechanisms underlying the differential efficacy of TDF and TAF is insightful. Including more diverse patient populations enhances analytical approach, provides a nuanced understanding of anti-HBV agent effectiveness and contributes to a personalized medicine approach in hepatology. Including sensitivity analyses helps validate findings. Declarations Funding This commentary did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. The author declare that no honorarium, grant, or other form of payment was given to anyone to produce the manuscript. Conflict of interest The author declares no conflict of interest exists. Consent to publish Not applicable. Availability of data and materials All data generated or analyzed during this study are included in this published article. Acknowledgment N/A References 1. Xu B, Zhang X, Liu F, Li F, Zhang X, Xiang H, et al. Effect of antiviral therapy on 3-year recurrence and prognosis of hepatocellular carcinoma after curative radiofrequency ablation. World J Gastrointest Oncol 2025;17: 112689. 2. Abu Zeid WA RD, Shemis MA,. Prevalence of mutations within major hydrophilic region of hepatitis B virus and their correlation with genotypes among chronically infected patients in Egypt. Arab Journal of Gastroenterology 2016 17 (2016) 34–40. 3. Thakur V, Guptan RC, Kazim SN, Malhotra V, SK. S. Profile, spectrum and significance of HBV genotypes in chronic liver disease patients in the Indian subcontinent. . J Gastroenterol Hepatol. 2002;17:165-70. 4. Wai CT, Fontana RJ, Polson J, Hussain M, Shakil AO, Han SH, et al. US Acute Liver Failure Study Group. Clinical outcome and virological characteristics of hepatitis B-related acute liver failure in the United States. J Viral Hepat. 2005 12:192-8. 5. Yuan B, Li R, Yuan W, Xiang B, Zheng M, Yang T, et al. Perioperative entecavir for patients with HBV-related hepatocellular carcinoma and low levels of viral DNA: analysis using propensity score matching. Oncotarget. 2017 16(31):51810-6. 6. Yoo S, Jang J, Kwon J, Jung S, Jang B, Choi J. Preemptive antiviral therapy with entecavir can reduce acute deterioration of hepatic function following transarterial chemoembolization. . Clin Mol Hepatol. 2016 22:458-65. 7. Hwang S, Song G, Jung D, Yoon Y, Yoo H, Tak E. High-dose tenofovir is not effective in suppressing hepatitis B virus replication in patients with hepatocellular carcinoma progression: a preliminary result. Korean J Hepatobiliary Pancreat Surg.2016(1). 8. Cho H, Ahn H, Lee DH, Lee JH, Jung YJ, Chang Y, et al. Entecavir and tenofovir reduce hepatitis B virus-related hepatocellular carcinoma recurrence more effectively than other antivirals. . Journal of viral hepatitis. 2018;25:707–17. 9. Choi J, Jo C, Lim YS. Tenofovir Versus Entecavir on Recurrence of Hepatitis B Virus-Related Hepatocellular Carcinoma After Surgical Resection. Hepatology (Baltimore, Md). 2021 73(661–673). 10. Lee JH, Kim BK, Park SY, Tak WY, Park JY, Kim DY, et al. The efficacies of entecavir and tenofovir in terms of enhancing prognosis after curative treatment of hepatitis B virus-related hepatocellular carcinoma. . Eur J Intern Med.2021:48-55. 11. Shen J, Qi W, Dai J, Leng S, Jiang K, Zhang Y, et al. Tenofovir vs. entecavir on recurrence of hepatitis B virus-related hepatocellular carcinoma beyond Milan criteria after hepatectomy. . Chinese medical journal. 2021;135:301–8. 12. Wang XH, Hu ZL, Fu YZ, Hou JY, Li WX, Zhang YJ, et al. Tenofovir vs. entecavir on prognosis of hepatitis B virus-related hepatocellular carcinoma after curative resection. . Journal of gastroenterology. 2022;57:185–98. 13. Hu Z, Zeng H, Hou J, Wang J, Xu L, Zhang Y, et al. Tenofovir vs. Entecavir on Outcomes of Hepatitis B Virus-Related Hepatocellular Carcinoma after Radiofrequency Ablation. Viruses. 2022;14(656). 14. Giri S, Agrawal D, Afzalpurkar S, Gopan A, Angadi S, Sundaram S. Tenofovir versus entecavir for tertiary prevention of hepatocellular carcinoma in chronic hepatitis B infection after curative therapy: A systematic review and meta-analysis. . Journal of viral hepatitis. 2023;30:108–15. 15. Kong Q GQ, Li W, Chen Z. Effect of tenofovir versus entecavir on the long-term prognosis in hepatocellular carcinoma patients with concurrent metabolic dysfunction-associated steatotic liver disease and hepatitis B. Asian J Surg. 2024 Nov;47(11):4725-4734. doi: 10.1016/j.asjsur.2024.03.147. Epub 2024 Sep 16. PMID: 39289060. 16. Qiu Z XY, Qi W, Shen J, Wen T, Li C. Tenofovir vs Entecavir on the Prognosis of Patients With Hepatitis B Virus-Related Hepatocellular Carcinoma After Liver Resection: The Role of HBsAg Levels. Clin Transl Gastroenterol. 2025 Mar 1;16(3):e00814. doi: 10.14309/ctg.0000000000000814. PMID: 39791573; PMCID: PMC11932590. 17. Liu J BS, Shi X, Yuan T, Yu Y, Lin J, Dai C, Wu Y, Cui L, Zhu B, Fu X, Wang K, Yu W, Li J. Benefits of entecavir therapy in HBV-related hepatocellular carcinoma patients with compensated cirrhosis after hepatectomy: A ten-year retrospective cohort study. Eur J Surg Oncol. 2025 May;51(5):109621. doi: 10.1016/j.ejso.2025.109621. Epub 2025 Jan 23. PMID: 39919509. "
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Xu BG, Zhang X, Liu F, Li FH, Zhang X, Xiang HL, Liang J. Effect of antiviral therapy on 3-year recurrence and prognosis of hepatocellular carcinoma after curative radiofrequency ablation. World J Gastrointest Oncol 2025; 17(11): 112689
8
"This study has provided a combined method including ultrasound and endoscopic examination to present the clinical features of ..."
[Read more]
"This study has provided a combined method including ultrasound and endoscopic examination to present the clinical features of pancreatic cancer in patients with old age. The lifestyles of these patients can be analyzed to perform the potential relationship in the prognosis of pancreatic cancer. In addition, the important features in malignant level as this study displayed may be summarized by author's efforts to indicate significantly and meaningfully in the prognosis of pancreatic cancer in patients. "
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Zignani N, Balzarini M, Dabizzi E, Fracas E, Millefanti L, Segato S, Vecchi M, Cengia G, Missale G, Tontini GE, Moneghini D, Cavallaro F. Endoscopic ultrasound features of pancreatic solid lesions: Descriptive and predictive analysis on a multicenter sample. World J Gastrointest Endosc 2025; 17(11): 112487
9
"The comprehensive review by Professor Elsayed offers a timely and insightful overview of a critical clinical challenge: the management ..."
[Read more]
"The comprehensive review by Professor Elsayed offers a timely and insightful overview of a critical clinical challenge: the management of recurrent hepatocellular carcinoma (RHCC). As a clinician actively managing HCC patients, I find this synthesis of evidence exceptionally valuable. RHCC indeed lacks standardized guidance, and this review effectively consolidates fragmented data across surgical, locoregional, and systemic modalities, offering pragmatic approaches tailored to recurrence patterns (intrahepatic vs. extrahepatic), liver functional reserve, and prior interventions. RHCC complexity demands collaboration between hepatologists, surgeons, interventional radiologists, and oncologists—highlighted here as essential for optimizing outcomes. The candid discussion on limitations—such as the reduced functional liver remnant post-resection/transplant, donor shortages for salvage LT (SLT), and the aggressive biology of RHCC—grounds the review in clinical reality. Coverage of emerging strategies—like combination therapies (TACE + sorafenib), novel ICIs (e.g., atezolizumab/bevacizumab), and AI-driven recurrence prediction—provides hope and direction for ongoing research. While ther are some points for further discussion. In practice, SLT candidates often face adverse factors (e.g., time to recurrence "
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Elsayed MOK. Treatment of recurrent hepatocellular carcinoma: The current standards and future perspectives. World J Gastrointest Oncol 2025; 17(11): 110735
10
"The study provides strong evidence that circulating GDF15 levels are elevated in IBD patients, with a clear correlation to markers ..."
[Read more]
"The study provides strong evidence that circulating GDF15 levels are elevated in IBD patients, with a clear correlation to markers of inflammation and intestinal permeability. This relationship could offer a new avenue for monitoring disease progression and assessing the severity of IBD. The results showing that GDF15 impacts the intestinal barrier function by modulating tight junctions such as ZO-1 and claudin 1 are especially intriguing. From a clinical standpoint, understanding how GDF15 contributes to barrier dysfunction could lead to new therapeutic targets aimed at preventing the "leaky gut" phenomenon, which is a key feature in IBD. One of the most interesting aspects is the suggestion that GDF15 could be a potential biomarker for intestinal permeability, which could be valuable in both clinical diagnosis and disease monitoring. However, as a clinician, I’d like to see more clarity on how these findings might translate into practical treatment strategies. For instance, how could we use this information to develop therapies targeting GDF15 or its signaling pathways in patients with IBD? Additionally, while the in vitro findings are compelling, clinical trials will be essential to confirm whether modulating GDF15 can indeed improve clinical outcomes for IBD patients. "
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Ruiz-Malagón AJ, Herraiz-Vilela M, Serrano-Pino R, García-Ávila P, Díaz- Suárez L, Carmona-Segovia AD, Becerra-Munoz VM, Jiménez-Navarro M, Arranz-Salas I, López-Villodres JA, Fernández-Castañer A, Gutiérrez-Martínez F, Rodríguez-González FJ, Camargo-Camero R, Alcaín-Martínez G, Rodríguez-Díaz C, García-Fuentes E, Sánchez-Quintero MJ, López-Gómez C. Growth differentiation factor 15 alters intestinal barrier and increases permeability: A new molecular target in inflammatory bowel disease. World J Gastroenterol 2025; 31(41): 110955
11
"As a clinician, I found this study highly relevant and practical. The use of VCTE to assess liver fibrosis in PBC patients offers ..."
[Read more]
"As a clinician, I found this study highly relevant and practical. The use of VCTE to assess liver fibrosis in PBC patients offers a non-invasive, reliable alternative to liver biopsies, which is a huge advantage in daily practice. The dual cut-off approach for diagnosing advanced fibrosis seems useful, providing clear thresholds that can guide treatment decisions without the need for invasive procedures. However, the grey area (10-14.5 kPa) remains a challenge, and it would be helpful to have additional tools or markers for better decision-making in these cases. Overall, this study offers a valuable, non-invasive method for fibrosis assessment, but more research on managing patients in the grey zone would be beneficial. "
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Chen JL, Hou YX, Liu Y, Jiang YY, Wang XB. Real-world performance of transient elastography in assessing advanced fibrosis in Chinese patients with primary biliary cholangitis. World J Gastroenterol 2025; 31(41): 111256
12
"Transient Elastography is an easy, bedside, non-invasive test for assessing liver fibrosis. PBC is a condition for which earlier ..."
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"Transient Elastography is an easy, bedside, non-invasive test for assessing liver fibrosis. PBC is a condition for which earlier diagnosis and treatment are associated with a better prognosis. So, evaluating Fibrosis has important diagnostic and therapeutic implications in PBC. However, studies on TE in PBC are limited to Asian settings, and the study by Jia-Liang Chen provides important data in this subset. In this retrospective study, they compared TE with the gold-standard findings of liver biopsy. They showed that TE is highly accurate for diagnosing Advanced fibrosis, and LSM has outperformed other fibrotic markers in ROC curves. Furthermore, they have classified patients with LSM into early, indeterminate, and late stages based on the LSM cut-off; these stages may have future prognostic significance. Future Prospective observational studies can be conducted to assess changes in LSM with treatment, disease progression, or complications. "
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Chen JL, Hou YX, Liu Y, Jiang YY, Wang XB. Real-world performance of transient elastography in assessing advanced fibrosis in Chinese patients with primary biliary cholangitis. World J Gastroenterol 2025; 31(41): 111256
13
"The authors presented a case of pancreatic tuberculosis and provided a detailed analysis of the diagnostic process, which holds ..."
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"The authors presented a case of pancreatic tuberculosis and provided a detailed analysis of the diagnostic process, which holds significant reference value for the diagnosis of similar cases. However, the report lacks an in-depth discussion and evaluation of the treatment approach and therapeutic strategy employed in this case, thereby limiting its applicability in guiding clinical management of analogous conditions. Consequently, the inclusion of a comprehensive treatment plan would substantially enhance the clinical utility and overall contribution of this case report. "
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Nima CL, Wang HG, Zhou Q. Pancreatic tuberculosis: A case report and review of literature. World J Gastroenterol 2025; 31(41): 110398
14
"This study has compared several computational methods to be used in the predication of prognosis for acute variceal bleeding in ..."
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"This study has compared several computational methods to be used in the predication of prognosis for acute variceal bleeding in cirrhosis patients. Author claimed that the convolution network by their efforts displayed the best effect in the outcomes analysis rather than another methods. However, the specific features in different subgroups with data presentations using AI or other computational methods lacked in the full analysis to be performed in the compared computation process. This means that this study only provides the end result for supporting their analysis as they wanted. In addition, the standard between high and low risk group presented to differ significantly without clinical parameters in this study. "
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Xiang Y, Yang N, Zheng TL, Huang YF, Liu TY, Ma DQ, Hu SJ, Zhang WH, Xiang HL, Zhang LY, Yuan LL, Wang X, Dang T, Zhang G, Wu B, Peng LJ, Gao M, Xia DL, Liu ZB, Li J, Song Y, Zhou XQ, Qi XS, Zeng J, Tan XY, Deng MM, Fang HM, Qi SL, He S, He YF, Ye B, Wu W, Shao JB, Wei W, Hu JP, Yong X, He CH, Bao JL, Zhang YN, Ji R, Bo Y, Yan W, Li HJ, Li SL, Geng S, Zhao L, Liu B, Qi XL. Development of a deep learning model for guiding treatment decisions of acute variceal bleeding in patients with cirrhosis. World J Gastroenterol 2025; 31(41): 111361
15
"This article is a well-conducted clinical study that elucidates the psychological profiles of patients undergoing esophagectomy for ..."
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"This article is a well-conducted clinical study that elucidates the psychological profiles of patients undergoing esophagectomy for esophageal cancer. Its core contributions lie in: 1. Demonstrating a significant negative correlation among anxiety, depression, and mindfulness, advancing understanding of the mind–body interaction in surgical oncology; 2. Identifying key demographic and clinical risk factors that shape postoperative emotional outcomes, thereby guiding individualized psychological assessment and intervention. By linking psychometric evaluation with perioperative management, this study offers a valuable reference for integrating mindfulness-based strategies into holistic recovery pathways. "
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Deng X, Hu YH, Xiong YJ, Mao N, Hong B, He G. Correlation of anxiety and depression with mindfulness in esophageal cancer patients undergoing esophagectomy and analysis of risk factors. World J Psychiatry 2025; 15(9): 104813
16
"The article is well-written and demonstrates a clear and logical flow from the introduction to the conclusion. The research objectives ..."
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"The article is well-written and demonstrates a clear and logical flow from the introduction to the conclusion. The research objectives are clearly stated, and the study design appropriately addresses the research questions. The literature review is comprehensive and up to date, providing a strong theoretical foundation for the study. The methodology is well-described, enabling replication, and the data analysis is appropriate and rigorous. The discussion effectively interprets the findings in relation to existing studies, and the conclusions are supported by the results. Overall, this is a good-quality manuscript that makes a valuable contribution to the field. "
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Yanti L, Surtiningsih, Ardiyani FHN, Sekarini NNAD, Susanti D, Mustaan, Murniati, Supriyadi, Santosa A. Long-term consequences of unintended pregnancy: Impacts on early childhood growth and development in a multicenter study. World J Clin Pediatr 2025; 14(4): 107346
17
"The retrospective study by Huang and colleagues provides valuable insights into the prevalence and clinicopathological significance ..."
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"The retrospective study by Huang and colleagues provides valuable insights into the prevalence and clinicopathological significance of HER2 expression in upper tract urothelial carcinoma. Their finding that HER2 overexpression is strongly associated with high tumor grade but not with conventional markers of disease progression underscores the distinct biological behavior of UTUC compared to bladder cancer. This work is particularly relevant as it highlights a potential therapeutic target in a disease with limited treatment options. However, the clinical implications of HER2 expression in UTUC must now be reinterpreted in light of the practice changing results presented at the ESMO Congress 2025. The phase 3 RC48 C016 trial demonstrated for the first time that a combination of the anti HER2 antibody drug conjugate disitamab vedotin and the anti PD1 immunotherapy toripalimab significantly outperforms standard platinum based chemotherapy in the first line treatment of HER2 expressing locally advanced or metastatic urothelial carcinoma. The results are striking: Progression free survival was nearly doubled (13.1 months versus 6.5 months; HR = 0.36); Overall survival showed a remarkable improvement (31.5 months versus 16.9 months; HR = 0.54); Benefits were consistent across all HER2 expression levels (IHC 1+, 2+, and 3+); and The combination also exhibited a more favorable safety profile. These findings represent a paradigm shift. For the first time, a biomarker directed strategy has proven superior to chemotherapy in the first line setting for advanced UC. Given that HER2 expression is found in up to 70% of urothelial carcinomas, this new regimen could benefit a majority of patients. In this context, the work by Huang et al gains even greater importance. Their observation that nearly half of UTUC tumors (46.2%) show HER2 positivity especially in high grade disease suggests that a substantial proportion of UTUC patients may be candidates for this novel, highly effective combination therapy. The authors call for clinical trials evaluating HER2 targeted therapies in high grade, HER2 positive UTUC is now more urgent than ever. Future studies should urgently validate the efficacy of disitamab vedotin plus toripalimab in UTUC specific cohorts and explore its potential in earlier disease stages. The era of biomarker driven therapy for urothelial carcinoma has arrived, and HER2 is firmly at its center. Reference: Sheng X, He Z, Zhang G, et al. Primary results from the phase 3 RC48 C016 trial: Disitamab vedotin plus toripalimab versus chemotherapy as first line treatment for HER2 expressing locally advanced or metastatic urothelial carcinoma. Annals of Oncology 2025;36(Supplement 3):S1573 S1574. "
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Huang L, He J. Human epidermal growth factor receptor 2 overexpression is associated with high-grade tumors in upper tract urothelial carcinoma. World J Clin Oncol 2025; 16(10): 110047
18
"This review on the gut-liver axis provides a highly insightful and comprehensive exploration of the evolving role of the microbiome ..."
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"This review on the gut-liver axis provides a highly insightful and comprehensive exploration of the evolving role of the microbiome in liver diseases. It successfully ties together mechanisms of microbiome dysbiosis with the pathogenesis of various hepatic conditions, including metabolic dysfunction-associated liver disease, cirrhosis, and cholangiopathies. The authors delve into how imbalances in gut microbiota disrupt bile acid metabolism, increase intestinal permeability, and promote inflammation, which in turn drives liver injury. The article's coverage of emerging treatment options, including bacteriophage therapy and genetic engineering of gut microbes, is particularly noteworthy, reflecting a growing understanding of the microbiome's potential as a therapeutic target. This forward-thinking approach adds substantial clinical relevance, making the article valuable for researchers and clinicians looking to integrate microbiome-based therapies into practice. "
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Anis MA, Shahid Y, Majeed AA, Abid S. Microbiome and gut-liver interactions: From mechanisms to therapies. World J Gastroenterol 2025; 31(40): 111409
19
"This study offers a compelling and innovative exploration of colonoscopy quality, addressing the critical interplay between insertion ..."
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"This study offers a compelling and innovative exploration of colonoscopy quality, addressing the critical interplay between insertion time and withdrawal duration to optimize adenoma detection rate (ADR). The proposed "insertion-to-withdrawal" paradigm marks a significant departure from fixed withdrawal time standards, advocating for a personalized approach—a novel and practical advancement. The development of a Shiny app to deliver real-time, individualized guidance further enhances its clinical relevance, providing endoscopists with a valuable tool to improve outcomes. Several aspects warrant deeper consideration. First, the hybrid SVM-XGBoost model's modest discriminative performance (AUC ≈ 0.64) suggests limitations in its current predictive power, likely due to unaddressed variables such as bowel preparation nuances, insertion difficulty, or segment-specific inspection times. Expanding the dataset with multicenter inputs and incorporating these factors could refine its accuracy. Second, while insertion time serves as a proxy for procedural complexity, its validation against objective difficulty scales or video analysis would bolster the mechanistic basis of the findings. Third, the personalized strategy’s generalizability remains untested; prospective multicenter validation across diverse demographics, endoscopist expertise, and regions is essential. Finally, evaluating real-world app adoption and its impact on ADR adherence would provide critical evidence of its efficacy. Overall, this study lays a robust foundation for data-driven personalization in endoscopy, moving beyond uniform metrics. With further refinement and validation, it has the potential to transform clinical practice significantly. "
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Xu BX, Xu CZ, Zhang HY, Chen XJ, Wei BN, Yang C. Personalizing withdrawal time by insertion time to achieve target adenoma detection rate in colonoscopy. World J Gastroenterol 2025; 31(38): 111364
20
"I want to congratulate Yang-Yang Xiong for publishing an excellent study comparing Endoscopic Clip or EUS Coil-assisted glue for ..."
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"I want to congratulate Yang-Yang Xiong for publishing an excellent study comparing Endoscopic Clip or EUS Coil-assisted glue for gastric varices. The authors have shown that EUS-guided therapy is more costly and involves high operating time; however, it has similar technical eradication of gastric varices and re-bleeding rates even in larger varices > 4 cm. The size comparison may not be uniform, as the Endoscopic group measured by endoscopic appearance, which may be as accurate as EUS measurement. The Authors have shown only a 5-day rebleeding rate; adding delayed rates could have been more impactful. There is a discrepancy in the table and image regarding post-injection ulcer; the Image shows a post-glue ulcer in both groups, whereas in the table, it was zero; these typographical errors could have been avoided. The eradication time frame is not mentioned; whether it is immediately or 5 days, as the rebleeding rate or any other time frame is not clear. The Follow up endoscopy data is not given; if done even after CT showing eradication of varices or for other GI Bleeding, the time at which it was done was not mentioned, and the procedure done when eradication is not established is also not given. Despite these limitations the study has provided a meaning ful comparison and can change my practice "
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Xiong YY, Li DW, Zhou TY, Ma H, Gao JG, Shen Z, Xu CF, Yu CH. Clip-assisted endoscopic cyanoacrylate injection vs endoscopic ultrasound-guided coil and cyanoacrylate injection for gastric varices: A propensity score-matched study. World J Gastroenterol 2025; 31(38): 111363
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