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431 items Read more >>
1
"it was a good experience, however the speed of review could be hastened. The changes that reviewer asked were well justified. I would ..."
[Read more]
"it was a good experience, however the speed of review could be hastened. The changes that reviewer asked were well justified. I would be willing to submit another manuscript in BPG journals again. The best part is the quick availability of the manuscript online. This is very encouraging to the authors. "
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Semwal P, Saini MK, Sarma MS. Understanding antituberculosis drug-induced hepatotoxicity: Risk factors and effective management strategies in the pediatric population. World J Clin Pediatr 2025; 14(2): 101875
2
"Initial peer review process [from submission to 1st review report ] , if little bit quicker then it will be more helpful for authors. ..."
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"Initial peer review process [from submission to 1st review report ] , if little bit quicker then it will be more helpful for authors. It will be easier if all the reviews come together and in one mail and in one mail review-submission deadline is mentioned . Otherwise sometimes there is a chance of missing the last date. Otherwise the whole service is satisfactory "
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Acharyya BC, Mukhopadhyay M. Escalation of soya cross-allergy in infants with cow's milk allergy. World J Clin Pediatr 2025; 14(2): 101663
3
"The manuscript editing and publishing process is perfect. The peer review report for my manuscript is fair and objective. I am ..."
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"The manuscript editing and publishing process is perfect. The peer review report for my manuscript is fair and objective. I am satisfied with the editing quality of the article. The period of publication is fine. We greatly appreciate the efficient, professional and rapid processing of our paper by the editors. Thank you and best regards. "
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Wu YL, Jing YL, Liu WH, Gong XY, Che L, Xue JY, Li TY, Jiang L, Huang XY, Yu WL, Weng YQ. Nomogram for predicting myocardial injury in pediatric patients undergoing living donor liver transplantation for biliary atresia. World J Gastrointest Surg 2025; 17(4): 103263
4
"The process of our manuscript's publication was subject to a rigorous and meticulous peer review procedure. The reviewers carried ..."
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"The process of our manuscript's publication was subject to a rigorous and meticulous peer review procedure. The reviewers carried out an all-encompassing assessment of our article, meticulously examining every aspect from its theoretical framework to the accuracy of the data presented. They provided us with in-depth and detailed comments and suggestions for revision, which were of great significance in enhancing the overall quality, academic rigor, and logical coherence of our manuscript. Moreover, the editorial team of the journal demonstrated exceptional efficiency in handling our submission. Their prompt responses, clear communication, and professional guidance throughout the process ensured that the entire submission workflow was highly streamlined and free from unnecessary delays or complications. Finally, we would like to extend our most sincere and profound appreciation to both the editors and reviewers for their invaluable contributions and dedicated efforts in reviewing and processing our manuscript. Their expertise and attention to detail have been instrumental in bringing our work to a publishable standard, and we are truly grateful for their support and guidance. "
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Zhang H, Zhou Y, Jiang YH, Hu WP, Huang LL, Lin HX, Zuo ZG, Du JM, Lou YL. Altered microbiota of rectal mucosa in rectal cancer patients. World J Gastroenterol 2025; 31(13): 105248
5
"Many thanks to the journal editors and reviewers. I have no further comments. The process is a bit lengthy, and many documents must ..."
[Read more]
"Many thanks to the journal editors and reviewers. I have no further comments. The process is a bit lengthy, and many documents must be submitted. I hope to make it easier by eliminating unnecessary documents. Thanks again for the usual support, and looking forward to submitting more articles Best regards Abdulqadir "
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Ali S, Anjum A, Khalid AR, Sultan MA, Noor S, Nashwan AJ. Unexpected finding of cholecystogastric fistula in a patient undergoing laparoscopic cholecystectomy: A case report. World J Clin Cases 2025; 13(19): 104148
6
"I think there are too many documents to submit for revision, and we spent a long time preparing for it, especially since the language ..."
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"I think there are too many documents to submit for revision, and we spent a long time preparing for it, especially since the language certificate is mandatory. It would be great if this part of the process could be simplified. The peer review was professional and fast. Everything was great, and I appreciate the professionalism, hard work, and effort of the editor. "
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Peng H, Yao N, Song YP, Huang L, Chen HB, Jiang Y, Chen QG. Motoric cognitive risk syndrome: A review of fall risk assessment and management strategies. World J Psychiatry 2025; 15(4): 101800
7
"Overall, I am highly satisfied with the journal’s online submission platform, which offers an efficient and user-friendly ..."
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"Overall, I am highly satisfied with the journal’s online submission platform, which offers an efficient and user-friendly experience.The peer review system struck a balance between thoroughness and timeliness. Reviewers provided detailed, constructive feedback, demonstrating expertise in the subject matter. While the process was rigorous, the editorial team facilitated smooth communication, promptly addressing queries and ensuring revisions were handled efficiently. The platform’s integration of anonymized reviews and real-time tracking streamlined collaboration. "
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Xiong SY, Liu CJ, Li YF, Zhang HL, Chen XW, Wang HM, Chen JC. Multimodal diagnostic and surgical approach to spontaneous esophageal rupture induced by severe coughing: A case report. World J Gastrointest Surg 2025; 17(4): 101578
8
"First of all, I would like to thank the magazine for accepting my manuscript. Especially in the process of revising the manuscript, ..."
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"First of all, I would like to thank the magazine for accepting my manuscript. Especially in the process of revising the manuscript, the editor's careful guidance and rigorous attitude deeply impressed us. Of course, we also try our best to revise, according to the requirements of the magazine, the editor's opinion to revise the article. Secondly, in the process of publishing the manuscript, I need to provide a lot of things, and I can't reply in time, or I have to wait for the reply from the work unit (hospital), but the chief editor can understand and understand. Finally, in terms of the process, we also try to cooperate with the requirements of the magazine. We are very grateful for the publication process of this article, and we have made our article better through continuous learning. "
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Lu YT, Zhang X, Cheng J. Meta-analysis of the effect of cognitive stimulation therapy on cognitive function in patients with Alzheimer's disease. World J Psychiatry 2025; 15(4): 102542
9
"Dear colleagues in the peer review process, One of the most important parameters in the article process is evaluation. In this process, ..."
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"Dear colleagues in the peer review process, One of the most important parameters in the article process is evaluation. In this process, the authors have made great contributions to the article by looking at it from a different perspective and making it more valuable. Therefore, I thank you very much. You spent your valuable time in this evaluation process. Again, the publisher's meticulous follow-up and control of this process was very good. Thank you for everything. "
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Yakut A. Gut microbiota in the development and progression of chronic liver diseases: Gut microbiota-liver axis. World J Hepatol 2025; 17(3): 104167
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"The findings presented here are a result of rigorous analysis and collaboration, and I hope they contribute to the ongoing discourse ..."
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"The findings presented here are a result of rigorous analysis and collaboration, and I hope they contribute to the ongoing discourse in this area. I would like to express my sincere gratitude to all those who supported this research, and I look forward to further discussions and developments in this field. "
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Zhang ZY, Li KJ, Zeng XY, Wang K, Sulayman S, Chen Y, Zhao ZL. Early prediction of anastomotic leakage after rectal cancer surgery: Onodera prognostic nutritional index combined with inflammation-related biomarkers. World J Gastrointest Surg 2025; 17(4): 102862
11
"Enjoyed the peer review process, which was efficient and effective. I think the submission system is user friendly, allow for rapid ..."
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"Enjoyed the peer review process, which was efficient and effective. I think the submission system is user friendly, allow for rapid communication between the journal and authors. Additionally enjoyed the clear and concise peer review report. Would do this all over again, if given another chance. Congratulations to the F6 publishing systems. Keep up the good work. Kevan English, MD Internal Medicine University of Nebraska Medical Center "
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English K. Brief insight regarding the use of transanal, laparoscopic, and robotic total mesorectal excision for rectal cancer. World J Gastrointest Surg 2025; 17(4): 102487
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"I am extremely satisfied with the entire submission process. From the initial guidelines to the final confirmation, everything was ..."
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"I am extremely satisfied with the entire submission process. From the initial guidelines to the final confirmation, everything was clear, efficient, and user-friendly. The platform was intuitive to navigate, and the instructions were comprehensive, leaving no room for confusion. The turnaround time for each step was also impressive. Overall, it was a seamless and positive experience, and I would highly recommend this submission process to other researchers and authors. It significantly reduced the stress typically associated with submitting work. "
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Feng SY, Ding ZR, Cheng J, Tu HB. Noninvasive prediction of esophagogastric varices in hepatitis B: An extreme gradient boosting model based on ultrasound and serology. World J Gastroenterol 2025; 31(13): 104697
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"We extend our deepest gratitude to the editorial team for your unwavering commitment, exceptional attention to detail, and invaluable ..."
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"We extend our deepest gratitude to the editorial team for your unwavering commitment, exceptional attention to detail, and invaluable contributions at every stage. Your professionalism and passion have not only enhanced the quality of our work but also made the entire creative process more rewarding. It’s an honor to collaborate with such a talented and dedicated team—your expertise inspires excellence, and we truly cherish this partnership. Thank you for everything! "
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Wei M, Jiang HB, Wang YY, Shi YH, Han Z, Gao YC. Control observation of different digestive tract reconstruction methods in total gastrectomy for gastric cancer. World J Gastrointest Surg 2025; 17(4): 101599
14
"Baishideng Publishing Group's publishing process was nice. The submission system and editors' approach left a positive impression. ..."
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"Baishideng Publishing Group's publishing process was nice. The submission system and editors' approach left a positive impression. The journal communication process was easy and convenient from submission to publishing. We thank the editors and peer reviewers for their important comments and editing. In addition, we would like to thank the editorial office for the technical assistance and wish Baishideng Publishing Group continued success in maintaining its high standards. "
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Potievskiy MB, Petrov LO, Ivanov SA, Sokolov PV, Trifanov VS, Grishin NA, Moshurov RI, Shegai PV, Kaprin AD. Machine learning for modeling and identifying risk factors of pancreatic fistula. World J Gastrointest Oncol 2025; 17(4): 100089
15
"Thank you very much to the editors and reviewers for their careful review and valuable suggestions on this manuscript. Their ..."
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"Thank you very much to the editors and reviewers for their careful review and valuable suggestions on this manuscript. Their constructive feedback has significantly improved the readability, clarity, and logical coherence of our work. We sincerely appreciate their time and effort, which have contributed to enhancing the overall quality of the manuscript. "
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Zhang YL, Song HB, Xue YW. Machine learning-based reconstruction of prognostic staging for gastric cancer patients with different differentiation grades: A multicenter retrospective study. World J Gastroenterol 2025; 31(13): 104466
16
"Thank you very much for your time, attention, and continued support throughout the entire editorial process. I am truly grateful for ..."
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"Thank you very much for your time, attention, and continued support throughout the entire editorial process. I am truly grateful for the insightful comments and constructive feedback you have provided, all of which have been invaluable in shaping and improving the quality of our manuscript. Your detailed and thoughtful review not only helped us refine our work but also guided us to think more critically and thoroughly about our research. The time and effort you devoted to reviewing and guiding our submission are deeply appreciated, and it has been a privilege to benefit from your expertise. We hope that the revised version now meets the expectations of the journal. Once again, thank you for your professional dedication and valuable contributions Best regards "
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Dolu S, Cengiz MB, Döngelli H, Gürbüz M, Arayici ME. Importance of hematological and inflammatory markers in the localization of gastric cancer. World J Gastrointest Oncol 2025; 17(4): 104455
17
"Thank you for your kind help. I would also like to thank the editors who handled this manuscript. The reviewers' comments were fair ..."
[Read more]
"Thank you for your kind help. I would also like to thank the editors who handled this manuscript. The reviewers' comments were fair and helped to improve the quality of this manuscript. The editors were quick to help me process the manuscript and responded promptly. I plan to continue to submit manuscripts to this journal. Once again, I appreciate your help. best regard "
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Byeon H. Innovative approaches to managing chronic multimorbidity: A multidisciplinary perspective. World J Clin Cases 2025; 13(19): 102484
18
"Thank you for your kind help. I would also like to thank the editors who handled this manuscript. The reviewers' comments were fair ..."
[Read more]
"Thank you for your kind help. I would also like to thank the editors who handled this manuscript. The reviewers' comments were fair and helped to improve the quality of this manuscript. The editors were quick to help me process the manuscript and responded promptly. I plan to continue to submit manuscripts to this journal. Once again, I appreciate your help. best regard "
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Byeon H. Enhancing autism care: The role of remote support in parental well-being and child development. World J Psychiatry 2025; 15(4): 102267
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"The publication process of the World Journal of Gastroenterology is truly commendable. From the initial submission to peer review, ..."
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"The publication process of the World Journal of Gastroenterology is truly commendable. From the initial submission to peer review, the editorial team ensures a seamless and efficient workflow. The peer review process is rigorous yet constructive, providing authors with valuable feedback to enhance their manuscripts. Once accepted, the editing and formatting stages are handled with professionalism and attention to detail. The final publication is timely, well-presented, and easily accessible, reflecting the journal’s commitment to high standards in scientific communication. Overall, the process is smooth, transparent, and highly supportive of authors, making it a pleasure to publish with this journal. "
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Hussain MS, Bisht AS, Gupta G. Reduced interleukin-2 receptor subunit γ expression in Crohn's disease: A potential mechanism for γδ T cell deficiency. World J Gastroenterol 2025; 31(13): 103180
20
"I sincerely appreciate the hard work and dedication of the editors, whose professional efforts have refined the article and enhanced ..."
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"I sincerely appreciate the hard work and dedication of the editors, whose professional efforts have refined the article and enhanced its academic quality. I am truly impressed and grateful for the journal's rigorous approach and outstanding editorial standards. I sincerely wish the journal continued success and growing academic influence, contributing even more high-quality research to the field! "
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Zheng T, Huang KY, Tang XD, Wang FY, Lv L. Endoplasmic reticulum stress in gut inflammation: Implications for ulcerative colitis and Crohn’s disease. World J Gastroenterol 2025; 31(13): 104671
18446 items Read more >>
1
"1 Ethics: Not applicable
2 Methods: Case report that the manuscript was prepared and revised according to the CARE Checklist ..."
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"1 Ethics: Not applicable
2 Methods: Case report that the manuscript was prepared and revised according to the CARE Checklist (2016).
3 Results: case sharing of case presentation, findings and images.
4 Figures and tables: The author provides perfect images which is good quality and easily understandable.
5 Biostatistics: Yes, the author provide perfect biostatistics data that complied with standard quality.
6 References: Record the latest references which are important in this field and related to the scientific problems and case addressed in the study.
7 Language: The language in article correctly, clearly and concisely express the information. No grammatical and language mistakes.
8 Caveats or drawbacks: Not detected"
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Lee J, Suh JW. Adenocarcinoma originating from a colonic duplication cyst: A case report. World J Gastrointest Surg 2025; 17(4): 103136
2
"1 Ethics: Not applicable
2 Methods: Case report that the manuscript was prepared and revised according to the CARE Checklist ..."
[Read more]
"1 Ethics: Not applicable
2 Methods: Case report that the manuscript was prepared and revised according to the CARE Checklist (2016).
3 Results: case sharing of case presentation, findings and images.
4 Figures and tables: The author provides perfect images which is good quality and easily understandable.
5 Biostatistics: Yes, the author provide perfect biostatistics data that complied with standard quality.
6 References: Record the latest references which are important in this field and related to the scientific problems and case addressed in the study.
7 Language: The language in article correctly, clearly and concisely express the information. No grammatical and language mistakes.
8 Caveats or drawbacks: Not detected"
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Wang ZM, Su S, Ling-Hu EQ, Chai NL. Type III choledochal cyst confirmed by aspiration and treated with endoscopic fenestration plus internal drainage: A case report. World J Gastrointest Surg 2025; 17(4): 104102
3
"1 Ethics: This retrospective study was approved by The Ethics Committee of the SBU Bursa Yuksek Ihtisas Research and Training Hospital ..."
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"1 Ethics: This retrospective study was approved by The Ethics Committee of the SBU Bursa Yuksek Ihtisas Research and Training Hospital provided its approval for our clinical research on 10.08.2022 with the decision number is 2011-KAEK–25 2022/08–02. This study adhered to the principles of the Declaration of Helsinki.
2 Methods: This retrospective method effective and proper method following guidelines and methods.
3 Results: The results true and authentic and significance validated that followed the objectives.
4 Figures and tables: The author provides perfect tables, images and graphic which is good quality and easily understandable.
5 Biostatistics: Yes, the author provide perfect biostatistics data that complied with standard quality.
6 References: Record the latest references which are important in this field and related to the scientific problems and research hypotheses addressed in the study.
7 Language: The language in article correctly, clearly and concisely express the information. No grammatical and language mistakes.
8 Caveats or drawbacks: Not detected"
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Ay OF, Firat D, Özçetin B, Ocakoglu G, Ozcan SGG, Bakır Ş, Ocak B, Taşkin AK. Role of pelvimetry in predicting surgical outcomes and morbidity in rectal cancer surgery: A retrospective analysis. World J Gastrointest Surg 2025; 17(4): 104726
4
"1 Ethics: This retropsective data is approved by Ethic Committee of Yulin First Hospital. The ethical approval form provided by the ..."
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"1 Ethics: This retropsective data is approved by Ethic Committee of Yulin First Hospital. The ethical approval form provided by the author meet the requirements.
2 Methods: This retrospective method effective and proper method following guidelines and methods.
3 Results: The results true and authentic and significance validated that followed the objectives.
4 Figures and tables: The author provide perfect tables and graphic which is good quality and easily understandable.
5 Biostatistics: Yes, the author provide perfect biostatistics data that complied with standard quality.
6 References: Record the latest references which are important in this field and related to the scientific problems and research hypotheses addressed in the study.
7 Language: The language in article correctly, clearly and concisely express the information. No grammatical and language mistakes.
8 Caveats or drawbacks: Not detected"
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Li WB, Li J, Yu W, Gao JH. Short-term efficacy of laparoscopic radical resection for colorectal cancer and risk of unplanned reoperation after surgery. World J Gastrointest Surg 2025; 17(4): 102442
5
"1 Ethics: This retrospective study was approved by the Liaocheng People’s Hospital Ethics Committee (approval No. 2022173). The ethical ..."
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"1 Ethics: This retrospective study was approved by the Liaocheng People’s Hospital Ethics Committee (approval No. 2022173). The ethical approval form provided by the author meet the requirements.
2 Methods: This retrospective method effective and proper method following guidelines and methods.
3 Results: The results true and authentic and significance validated that followed the objectives.
4 Figures and tables: The author provide perfect tables and graphic which is good quality and easily understandable.
5 Biostatistics: Yes, the author provide perfect biostatistics data that complied with standard quality.
6 References: Record the latest references which are important in this field and related to the scientific problems and research hypotheses addressed in the study.
7 Language: The language in article correctly, clearly and concisely express the information. No grammatical and language mistakes.
8 Caveats or drawbacks: Not detected"
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Du WF, Liang TS, Guo ZF, Li JJ, Yang CG. Comparison of outcomes of laparoscopic-assisted and total laparoscopic right hemicolectomy for right-sided colon cancer. World J Gastrointest Surg 2025; 17(4): 100476
6
"Fecal transplantation (FMT), which transplants gut bacteria from a healthy individual, is effective for IBD and Crohn's disease, and ..."
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"Fecal transplantation (FMT), which transplants gut bacteria from a healthy individual, is effective for IBD and Crohn's disease, and an increasing number of hospitals are promoting it. In the United States, fecal transplantation has proven highly effective in treating pseudomembranous colitis, and it is becoming clear that controlling the microbiota can be useful in treating intractable diseases. However, there have been reports of severe infections and deaths with FMT. Please comment on these as well."
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Liu HJ, Wu MC, Gau SY. Role of gut microbiota and mesenteric adipose tissue in the pathology of Crohn’s disease: Potential therapeutic targets. World J Gastroenterol 2025; 31(13): 102291
7
"Colonic duplication cysts are rare congenital cysts and commonly presenting before two years of age and rarely reported in adults. ..."
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"Colonic duplication cysts are rare congenital cysts and commonly presenting before two years of age and rarely reported in adults. Malignant change in a duplication is very rare, and adenocarcinoma is the most common histologic type of malignancy found in these unusual cases.
This is a well-written and presented rare case report and including recent papers. This manuscript gives additional new knowledge to the existing literatüre. I think that this manuscript is worth to publication.
"
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Lee J, Suh JW. Adenocarcinoma originating from a colonic duplication cyst: A case report. World J Gastrointest Surg 2025; 17(4): 103136
8
"Lan X, Zhang H, Chen ZY, Wang J, Zhang SC, Li Q, Ke JY, Wei W, Huang R, Tang X, Chen SP, Huang TT, Zhou YW. Suppressor of cytokine ..."
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"Lan X, Zhang H, Chen ZY, Wang J, Zhang SC, Li Q, Ke JY, Wei W, Huang R, Tang X, Chen SP, Huang TT, Zhou YW. Suppressor of cytokine signaling 2 modulates regulatory T cell activity to suppress liver hepatocellular carcinoma growth and metastasis. World J Gastroenterol 2025; 31(13): 100566 [DOI: 10.3748/wjg.v31.i13.100566]
SOCS2 modulates CD4+ T function in the TME, contributing to LIHC progression. Targeting SOCS2 presents a potential therapeutic strategy for treating LIHC.
1) In the title, "liver" may be deleted. This is only recommendation."
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Lan X, Zhang H, Chen ZY, Wang J, Zhang SC, Li Q, Ke JY, Wei W, Huang R, Tang X, Chen SP, Huang TT, Zhou YW. Suppressor of cytokine signaling 2 modulates regulatory T cell activity to suppress liver hepatocellular carcinoma growth and metastasis. World J Gastroenterol 2025; 31(13): 100566
9
"Sample Size: Details regarding the sample size and selection criteria are not provided, which are essential for assessing the study's ..."
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"Sample Size: Details regarding the sample size and selection criteria are not provided, which are essential for assessing the study's statistical power and generalizability.
Control Comparisons: Information on the inclusion of appropriate control groups is lacking, making it difficult to determine whether observed microbial alterations are specific to rectal cancer or part of broader gastrointestinal changes."
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Zhang H, Zhou Y, Jiang YH, Hu WP, Huang LL, Lin HX, Zuo ZG, Du JM, Lou YL. Altered microbiota of rectal mucosa in rectal cancer patients. World J Gastroenterol 2025; 31(13): 105248
10
"Weaknesses:
Retrospective Design: As a retrospective study, there may be inherent biases due to the use of existing data, which ..."
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"Weaknesses:
Retrospective Design: As a retrospective study, there may be inherent biases due to the use of existing data, which can affect the robustness of the findings.
Model Generalizability: The performance of the XGBoost model in diverse populations or external datasets is not discussed, which raises questions about its generalizability.
Lack of External Validation: Without validation in independent cohorts, the model's predictive power and clinical utility remain uncertain."
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Feng SY, Ding ZR, Cheng J, Tu HB. Noninvasive prediction of esophagogastric varices in hepatitis B: An extreme gradient boosting model based on ultrasound and serology. World J Gastroenterol 2025; 31(13): 104697
11
"Weaknesses:
Lack of Original Research: The review relies solely on existing studies without presenting new experimental data, ..."
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"Weaknesses:
Lack of Original Research: The review relies solely on existing studies without presenting new experimental data, limiting the ability to draw novel conclusions.
Insufficient Mechanistic Insights: While discussing ER stress's role, the review could benefit from more detailed exploration of underlying mechanisms and signaling pathways involved.
Zheng et al.'s review underscores the significance of ER stress in the inflammation of UC and CD, suggesting it as a promising target for therapeutic intervention. Addressing the identified weaknesses through focused research will enhance our understanding and treatment of these chronic inflammatory conditions."
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Zheng T, Huang KY, Tang XD, Wang FY, Lv L. Endoplasmic reticulum stress in gut inflammation: Implications for ulcerative colitis and Crohn’s disease. World J Gastroenterol 2025; 31(13): 104671
12
"Weaknesses:
Lack of Original Data: The letter presents a hypothesis without supporting original experimental data, relying ..."
[Read more]
"Weaknesses:
Lack of Original Data: The letter presents a hypothesis without supporting original experimental data, relying on existing literature, which limits the assessment of feasibility and potential impact.
Mechanistic Details: Insufficient information on the proposed mechanisms by which MLKL modulation could alleviate ALD symptoms hinders understanding of the underlying biology."
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Xi Y, Guo D, Li S, Guo JY, Chen XZ, Tang JF, Zhou CF. Targeting mixed lineage kinase domain-like protein's non-necroptosis role: A new horizon in anti-inflammatory therapy for alcoholic liver disease. World J Gastroenterol 2025; 31(13): 104546
13
"Weaknesses:
Data Quality and Consistency: Variations in data collection methods across multiple centers may introduce ..."
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"Weaknesses:
Data Quality and Consistency: Variations in data collection methods across multiple centers may introduce inconsistencies, potentially affecting the reliability of the ML model.
Model Interpretability: While ML models can offer predictive power, their complexity may hinder clinical interpretation. Ensuring that the model's decision-making process is transparent is crucial for clinical acceptance."
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Zhang YL, Song HB, Xue YW. Machine learning-based reconstruction of prognostic staging for gastric cancer patients with different differentiation grades: A multicenter retrospective study. World J Gastroenterol 2025; 31(13): 104466
14
"Weaknesses:
Study Design: The study's design details, such as sample size, inclusion criteria, and control measures, are not ..."
[Read more]
"Weaknesses:
Study Design: The study's design details, such as sample size, inclusion criteria, and control measures, are not provided in the available information. A comprehensive understanding of these aspects is essential to assess the study's robustness and generalizability.
Validation: Information regarding the validation process of the AI model, including training and testing datasets, cross-validation techniques, and performance metrics, is lacking. Transparency in validation is crucial to establish the model's reliability and clinical applicability."
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Ma T, Liu GQ, Guo J, Ji R, Shao XJ, Li YQ, Li Z, Zuo XL. Artificial intelligence-aided optical biopsy improves the diagnosis of esophageal squamous neoplasm. World J Gastroenterol 2025; 31(13): 104370
15
"Weaknesses:
Lack of Empirical Data: The letter does not provide original data or detailed methodology regarding the predictive ..."
[Read more]
"Weaknesses:
Lack of Empirical Data: The letter does not provide original data or detailed methodology regarding the predictive model, limiting the ability to assess its validity and applicability.
Model Validation: There is no mention of external validation or performance metrics (e.g., sensitivity, specificity) for the proposed model, which are crucial for determining its reliability.
Karniadakis et al. highlight the importance of predictive modeling in minimizing adverse events during minimally invasive esophageal surgery. To enhance the impact of this work, future studies should provide empirical data, validate the model externally, and detail its clinical application. Such efforts will contribute to the advancement of personalized surgical care and improved patient safety."
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Karniadakis I, Argyrou A, Vogli S, Papadakos SP. Towards personalized care in minimally invasive esophageal surgery: An adverse events prediction model. World J Gastroenterol 2025; 31(13): 104205
16
"The study titled "Nonalcoholic fatty liver disease following laparoscopic duodenum-preserving pancreatic total head resection vs ..."
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"The study titled "Nonalcoholic fatty liver disease following laparoscopic duodenum-preserving pancreatic total head resection vs laparoscopic pancreaticoduodenectomy: A retrospective cohort study" by Zhen et al. compares the incidence of nonalcoholic fatty liver disease (NAFLD) in patients undergoing two surgical procedures: laparoscopic duodenum-preserving pancreatic total head resection (LDPPHR) and laparoscopic pancreaticoduodenectomy (LPD). The findings suggest that patients who underwent LDPPHR had a lower incidence of postoperative NAFLD compared to those who underwent LPD. This difference may be attributed to the preservation of the duodenum and its associated hormonal functions in LDPPHR, which could play a role in maintaining liver metabolism and reducing the risk of NAFLD development. These results highlight the potential metabolic benefits of duodenum-preserving surgical techniques in pancreatic surgery."
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Zhen TT, Li SZ, Pan ST, Yin TY, Wang M, Guo XJ, Zhang H, Qin RY. Nonalcoholic fatty liver disease following laparoscopic duodenum-preserving pancreatic total head resection vs laparoscopic pancreaticoduodenectomy: A retrospective cohort study. World J Gastroenterol 2025; 31(13): 104046
17
"Weaknesses:
Lack of Empirical Data: The letter does not present original experimental data to substantiate the proposed ..."
[Read more]
"Weaknesses:
Lack of Empirical Data: The letter does not present original experimental data to substantiate the proposed hypothesis, relying instead on existing literature.
Limited Scope: As a letter to the editor, the discussion is concise, limiting the depth of analysis and exploration of alternative explanations
Hussain et al. provide an intriguing hypothesis regarding the role of IL-2Rγ in γδ T cell deficiency in Crohn's disease. Empirical studies are needed to validate this hypothesis, which could contribute to a deeper understanding of CD pathogenesis and inform the development of novel therapeutic approaches."
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Hussain MS, Bisht AS, Gupta G. Reduced interleukin-2 receptor subunit γ expression in Crohn's disease: A potential mechanism for γδ T cell deficiency. World J Gastroenterol 2025; 31(13): 103180
18
"Ye et al. provide valuable insights into the potential link between H. pylori infection and MASLD. Addressing the identified weaknesses ..."
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"Ye et al. provide valuable insights into the potential link between H. pylori infection and MASLD. Addressing the identified weaknesses through prospective studies and mechanistic investigations will enhance the impact of the research, fostering greater interest among readers and contributing to advancements in hepatology. Weaknesses:
Cross-Sectional Design: The observational nature limits the ability to infer causality between H. pylori infection and MASLD.
Confounding Variables: While adjustments were made, residual confounding factors may still influence the results."
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Ye L, Yan K, Tian Z, Xiao ZH, Xie RY, Xie ZY, Tao L. Helicobacter pylori infection is linked to metabolic dysfunction and associated steatotic liver disease: A large cross-sectional study. World J Gastroenterol 2025; 31(13): 102563
19
"Yu et al. provide valuable insights into the role of SEMA6A-AS1 in HCC suppression. Addressing the identified weaknesses through ..."
[Read more]
"Yu et al. provide valuable insights into the role of SEMA6A-AS1 in HCC suppression. Addressing the identified weaknesses through clinical correlation studies and in vivo validations will enhance the impact of the research, fostering greater interest among readers and contributing to advancements in HCC therapeutics. The precise mechanisms by which SEMA6A-AS1 promotes SEMA6A mRNA degradation remain to be fully elucidated. Future research should focus on identifying the molecular pathways involved and assessing the therapeutic potential of SEMA6A-AS1 modulation in HCC treatment."
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Yu SM, Zhang M, Li SL, Pei SY, Wu L, Hu XW, Duan YK. Long noncoding RNA semaphorin 6A-antisense RNA 1 reduces hepatocellular carcinoma by promoting semaphorin 6A mRNA degradation. World J Gastroenterol 2025; 31(13): 102527
20
"Liu et al. provide a valuable perspective on the potential therapeutic targets involving gut microbiota and MAT in Crohn's disease. ..."
[Read more]
"Liu et al. provide a valuable perspective on the potential therapeutic targets involving gut microbiota and MAT in Crohn's disease. Addressing the identified weaknesses by delving deeper into specific mechanisms and incorporating recent research will enhance the editorial's impact, fostering greater interest among readers and contributing to advancements in the field."
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Liu HJ, Wu MC, Gau SY. Role of gut microbiota and mesenteric adipose tissue in the pathology of Crohn’s disease: Potential therapeutic targets. World J Gastroenterol 2025; 31(13): 102291
15170 items Read more >>
Peer-Reviewers and Manuscript Statistics
- Editorial board members
- 2266
- Peer-reviewers
- 29964
- Manuscripts received today
- 21
- Manuscript reviews today
- 53
- Unhandled manuscripts today
- 207
- Active peer-reviewers today
- 2284
- Reviewer acceptance today
- 70
- Reviewer refusals today
- 68
- Total accepted manuscripts
- 35482
- Total rejected manuscripts
- 41148
- Total peer-reviewers
- 4153523
- Total submissions
- 33848
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1
"The study’s prospective design and the use of validated instruments, including a simplified Profile of Mood States and the Pittsburgh ..."
[Read more]
"The study’s prospective design and the use of validated instruments, including a simplified Profile of Mood States and the Pittsburgh Sleep Quality Index, are notable strengths. The findings demonstrate that the observation group, which received both CBT and MBSR, achieved significantly better outcomes in terms of reduced negative mood dimensions and improved sleep quality compared to the control group (CBT only). These results suggest that the dual intervention not only alleviates depressive symptoms but also enhances sleep quality, thereby addressing two interrelated facets of patient well-being. Zhang et al.’s study makes a valuable contribution by demonstrating that an integrated CBT and MBSR intervention can significantly improve both mood state and sleep quality in patients with diabetes and endometrial cancer. We encourage the authors to address the aforementioned aspects in future research to further refine and validate this promising therapeutic approach. Integrating detailed intervention protocols and extending follow-up durations will enhance the generalizability and clinical utility of their findings. "
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Zhang QS, Zhang W, Mao Y, Wang XS, Zhang JW, Cao YJ. Effects of cognitive combined with mindfulness-based stress reduction and sleep in patients with diabetes and endometrial cancer. World J Psychiatry 2025; 15(4): 100849
2
"This article is a high-quality academic editorial that systematically explores the potential value of PLD2 in acute pancreatitis (AP) ..."
[Read more]
"This article is a high-quality academic editorial that systematically explores the potential value of PLD2 in acute pancreatitis (AP) and proposes actionable future research directions. Its core contributions lie in: 1. Integrating molecular mechanisms with clinical applications, shifting AP biomarker research from "phenomenological association" to "mechanism-driven" investigation; 2. Emphasizing multi-omics integration and precision medicine, offering a novel paradigm for AP management. "
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Wang ZH, Lv JH, Teng Y, Michael N, Zhao YF, Xia M, Wang B. Phospholipase D2: A biomarker for stratifying disease severity in acute pancreatitis? World J Gastroenterol 2025; 31(11): 104033
3
"This study provides novel insights into the risk factors for metachronous gastric cancer (MGC) in elderly patients, particularly ..."
[Read more]
"This study provides novel insights into the risk factors for metachronous gastric cancer (MGC) in elderly patients, particularly highlighting the clinical significance of the association with metabolic dysfunction-associated steatotic liver disease (MASLD) and the proposed risk stratification system. However, the retrospective design and small sample size limit the robustness of the evidence, necessitating further validation through multicenter prospective studies. The paper is well-structured but requires refinement in statistical details. "
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Xiang Y, Yuan Y, Wang ZY, Zhu YM, Li WY, Ye QG, Wang YN, Sun Q, Ding XW, Longi F, Tang DH, Xu GF. Comorbidities related to metachronous recurrence for early gastric cancer in elderly patients. World J Gastrointest Endosc 2025; 17(3): 99540
4
"The author has constructed a predictive model with strong forecasting capabilities, designed to estimate the probability of a textbook ..."
[Read more]
"The author has constructed a predictive model with strong forecasting capabilities, designed to estimate the probability of a textbook outcome following surgery. Additionally, the study elucidates the machine learning computational process using the SHAP algorithm. This research is highly innovative, as it visualizes the otherwise opaque computational processes of machine learning, thereby enhancing its credibility. Clinicians can easily input specific clinical parameters of patients to obtain immediate, personalized risk assessments, enabling timely preventive measures and ensuring the best possible medical care for patients.This study substantiates the feasibility of explainable machine learning in future applications, marking a new direction in the research of predictive models and supervised learning. "
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Huang TF, Luo C, Guo LB, Liu HZ, Li JT, Lin QZ, Fan RL, Zhou WP, Li JD, Lin KC, Tang SC, Zeng YY. Preoperative prediction of textbook outcome in intrahepatic cholangiocarcinoma by interpretable machine learning: A multicenter cohort study. World J Gastroenterol 2025; 31(11): 100911
5
"This study provides valuable insights into the effectiveness of combining three-dimensional computed tomography (3D CT) reconstruction ..."
[Read more]
"This study provides valuable insights into the effectiveness of combining three-dimensional computed tomography (3D CT) reconstruction and laparoscopic techniques for accurately measuring the myopectineal orifice (MPO) in inguinal hernia repair. The research clearly demonstrates that preoperative 3D CT measurements closely match intraoperative laparoscopic findings, suggesting that CT could reliably guide surgical planning. The authors effectively highlight the clinical implications, emphasizing how precise measurement and patch placement can minimize complications such as nerve injury, recurrence, and chronic postoperative pain. Additionally, they provide a thoughtful analysis regarding demographic factors, noting significant differences in MPO measurements between sexes, while age and body mass index showed less impact. One of the strengths of this article is its detailed methodological description, which facilitates replication and further research. However, future studies might benefit from larger sample sizes and expanded demographic variability to enhance generalizability. Overall, the paper makes a significant contribution to personalized surgical approaches for inguinal hernia treatment. "
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Zhang L, Chen J, Zhang YY, Liu L, Wang HD, Zhang YF, Sheng J, Hu QS, Liu ML, Yuan YL. Three-dimensional reconstruction under computed tomography and myopectineal orifice measurement under laparoscopy for quality control of inguinal hernia treatment. World J Gastrointest Endosc 2025; 17(3): 104966
6
"As this is a editorial article, it has got no sections of methods, results, tables, biostatistics, units and ethical statement to ..."
[Read more]
"As this is a editorial article, it has got no sections of methods, results, tables, biostatistics, units and ethical statement to provide commentary on these sections. The editorial by Behrens and Elgafy provides an insightful analysis of factors influencing outcomes in indirect decompression through oblique and lateral lumbar interbody fusions (OLIF and LLIF). The discussion on patient selection criteria, particularly regarding preoperative spinal canal dimensions and lateral recess depth, is a valuable contribution to clinical decision-making. The emphasis on the unpredictability of outcomes in patients with severe lateral recess stenosis and the potential need for staged procedures highlights a crucial consideration for spine surgeons. However, one area that could benefit from further exploration is the long-term stability of indirect decompression compared to direct decompression, especially concerning adjacent segment disease and fusion longevity. Additionally, a deeper comparison of OLIF and LLIF in terms of specific complications and recovery trajectories would provide even greater clinical relevance. Overall, this editorial offers a comprehensive and well-referenced synthesis of the current literature on indirect decompression. It serves as a useful guide for surgeons considering minimally invasive approaches while remaining cautious about their limitations. "
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M Behrens KM, Elgafy H. Factors affecting outcomes of indirect decompression after oblique and lateral lumbar interbody fusions. World J Orthop 2025; 16(3): 100772
7
"The clinical significance of this study lies in its innovative approach to predicting colorectal polyp recurrence using machine ..."
[Read more]
"The clinical significance of this study lies in its innovative approach to predicting colorectal polyp recurrence using machine learning (ML), specifically the eXtreme Gradient Boosting (XGBoost) model. Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, largely preventable through early detection and effective management of precancerous polyps. Endoscopic mucosal resection (EMR) is widely utilized for the removal of colorectal polyps, yet it carries a considerable risk of recurrence, highlighting the need for accurate predictive tools to guide postoperative surveillance. This study identifies critical independent risk factors for polyp recurrence one year post-EMR, such as age, family history, smoking habits, diarrhea, Helicobacter pylori infection, polyp size, number of polyps, and hazard classification. By leveraging ML algorithms, particularly XGBoost, the researchers have developed a model with superior predictive performance, evidenced by high Area Under the Curve (AUC) values exceeding 0.90 across multiple validation cohorts, including a prospective validation set, indicating robust predictive accuracy and clinical utility. Clinically, the XGBoost model offers substantial advantages. Its high sensitivity, specificity, accuracy, precision, and F1 scores suggest that it effectively stratifies patients based on recurrence risk. Such a model significantly enhances personalized patient management by informing more accurate follow-up intervals, potentially improving patient outcomes through timely interventions and reducing unnecessary colonoscopies in low-risk individuals. Additionally, the authors' development of an accessible online web calculator based on this predictive model further underscores its practical utility in routine clinical practice. Clinicians can conveniently input patient-specific clinical parameters to obtain immediate, individualized risk predictions, facilitating shared decision-making between physicians and patients. Decision Curve Analysis further underscores the practical value of this tool, demonstrating that using the XGBoost model provides superior clinical net benefit compared to standard follow-up strategies. This methodical approach not only advances clinical decision-making but also optimizes healthcare resources by prioritizing surveillance for those most at risk. Finally, the interpretability of the model via SHapley Additive exPlanations (SHAP) analysis significantly mitigates concerns about the "black box" nature commonly associated with ML models, thus increasing clinician trust and acceptability. In conclusion, this ML-based predictive model represents a critical advancement in clinical gastroenterology, providing robust, data-driven support for clinicians in making individualized recommendations for colorectal polyp surveillance and potentially reducing colorectal cancer incidence through targeted early intervention. "
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Huang TF, Luo C, Guo LB, Liu HZ, Li JT, Lin QZ, Fan RL, Zhou WP, Li JD, Lin KC, Tang SC, Zeng YY. Preoperative prediction of textbook outcome in intrahepatic cholangiocarcinoma by interpretable machine learning: A multicenter cohort study. World J Gastroenterol 2025; 31(11): 100911
8
"The author has shown that knocking out SERPINB5 not only inhibits the proliferation and metastasis of cancer cells but also suppresses ..."
[Read more]
"The author has shown that knocking out SERPINB5 not only inhibits the proliferation and metastasis of cancer cells but also suppresses tumor growth in xenograft mice, effectively reducing tumor progression. This suggests that SERPINB5 could potentially serve as an important target for tumor treatment. We sincerely appreciate the author's dedication and hard work. The quality of this article is truly outstanding, and we eagerly look forward to your next research contribution. "
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Meng ZS, Hu JT, Wu H, Li BK. Inhibition of the SERPINB5/HSP90AA1 axis restrains the proliferation and invasion of rectal cancer. World J Gastroenterol 2025; 31(11): 103412
9
"This study provides valuable data specifically focused on endoscopic resection (ER) of esophageal GISTs. Thorough evaluation of the ..."
[Read more]
"This study provides valuable data specifically focused on endoscopic resection (ER) of esophageal GISTs. Thorough evaluation of the ER technique, complications, and resection margin status enhances our understanding of ER safety and effectiveness. Furthermore, the study presented a relatively large case series of 32 patients, which increases the statistical reliability of the findings for esophageal GIST research. By presenting long-term follow-up results, it assessed the long-term prognosis after ER and suggested potential benefits for future treatment strategy development. "
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Xu EP, Qi ZP, Zhang JW, Li B, Ren Z, Cai MY, Cai SL, Lv ZT, Chen ZH, Liu JY, Zhong YS, Zhou PH, Shi Q. Endoscopic treatment outcome of oesophageal gastrointestinal stromal tumours. World J Gastroenterol 2025; 31(10): 102393
10
"We greatly appreciate the authors and their team for their in-depth study on treatment strategies for rectal neuroendocrine neoplasms ..."
[Read more]
"We greatly appreciate the authors and their team for their in-depth study on treatment strategies for rectal neuroendocrine neoplasms (R-NENs). This retrospective analysis compares the efficacy of endoscopic full-thickness resection (EFTR) and endoscopic submucosal dissection (ESD) in the treatment of R-NENs, demonstrating the superior R0 resection rate of EFTR while maintaining comparable short-term safety with ESD. This study provides critical clinical evidence supporting the use of EFTR in R-NENs and contributes to the refinement of function-preserving surgical approaches. However, we would like to offer some constructive suggestions to enhance the clinical applicability and long-term evaluation of this study. First, some terminology and definitions in the study are somewhat ambiguous, which may affect the interpretability of the results. For instance, the study mentions that some patients had "severe comorbidities" but does not specify the types of comorbidities or the inclusion/exclusion criteria applied. Certain comorbidities, such as diabetes or chronic kidney disease, may impact postoperative healing, and failing to differentiate them could introduce confounding among patients with varying risk profiles. Additionally, the description of lesion morphology is inherently subjective, and the study does not clarify whether standardized imaging assessments, such as endoscopic ultrasound (EUS), were used to measure lesion size and invasion depth. Inconsistencies in preoperative evaluation criteria could lead to bias in treatment selection. For example, was EFTR preferentially chosen for lesions with specific morphological characteristics? Future studies should adopt more detailed imaging assessment criteria and pathological grading methods to improve reproducibility and the interpretability of results. Second, the study does not assess the impact of the learning curve for EFTR and ESD on surgical outcomes. As a relatively novel technique, EFTR may require a longer period of experience accumulation to achieve stable performance. The study does not clarify whether operator experience was comparable between the EFTR and ESD groups or whether surgical success rates varied with increasing experience. If EFTR procedures were performed by highly experienced endoscopists while ESD procedures involved a broader range of operators, the results could be biased in favor of EFTR. Additionally, since EFTR has a steeper learning curve, factors such as procedure time and complication rates may decrease with increased experience, but the study does not conduct a dynamic analysis of these trends. Future studies should incorporate learning curve analyses to evaluate the influence of experience on surgical outcomes, ensuring a fair comparison between the two techniques. Furthermore, EFTR may cause greater bowel wall injury than ESD, potentially affecting postoperative bowel function, yet this study focuses primarily on R0 resection rates and short-term complications without assessing long-term functional outcomes. As a full-thickness resection technique, EFTR may alter rectal compliance, bowel movement frequency, and gut motility. However, the study does not provide data on postoperative bowel function changes, alterations in defecation patterns, bloating, or incontinence. If EFTR improves R0 resection rates but increases the risk of postoperative functional impairment, its clinical utility must be considered more cautiously. Future research should incorporate patient-reported outcomes (PROs) and quality of life (QoL) assessments and include long-term functional evaluations such as anorectal manometry and bowel dysfunction scoring to comprehensively assess the impact of EFTR on patient prognosis. "
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Zhang XL, Jiang YY, Chang YY, Sun YL, Zhou Y, Wang YH, Dou XT, Guo HM, Ling TS. Endoscopic full-thickness resection: A definitive solution for local complete resection of small rectal neuroendocrine neoplasms. World J Gastroenterol 2025; 31(10): 100444
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"This is a well-constructed and well-written review, which gives readers with a general bioscience background updated information about ..."
[Read more]
"This is a well-constructed and well-written review, which gives readers with a general bioscience background updated information about the stem cell application in liver diseases (fatty liver diseases and steatohepatitis). The language is fluent, and the references are up to date. It will be easier for readers to understand the concepts if the authors provide a table to compare the 2D model with the 3D model. It will be helpful to include the abbreviation for each key word. "
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Silva B, Bragança J. Induced pluripotent stem cell-derived mesenchymal stem cells for modeling and treating metabolic associated fatty liver disease and metabolic associated steatohepatitis: Challenges and opportunities. World J Stem Cells 2025; 17(2): 99331
12
"The authors should provide adequate legends for each figure. Some parts of the paper are just a listing of facts and are poorly ..."
[Read more]
"The authors should provide adequate legends for each figure. Some parts of the paper are just a listing of facts and are poorly organized or discussed. The table in the paper is well organized and suited. A table to compare the pros and cons of different kinds of stem cells for muscle atrophy therapy will be helpful. "
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Wang YJ, Chen ZH, Shen YT, Wang KX, Han YM, Zhang C, Yang XM, Chen BQ. Stem cell therapy: A promising therapeutic approach for skeletal muscle atrophy. World J Stem Cells 2025; 17(2): 98693
13
"Stem Cell Therapy: A New Hope for Patients with Skeletal Muscle Atrophy? Skeletal muscle atrophy refers to the reduction or loss of ..."
[Read more]
"Stem Cell Therapy: A New Hope for Patients with Skeletal Muscle Atrophy? Skeletal muscle atrophy refers to the reduction or loss of muscle fibers due to nutritional deficiencies or diseases, leading to a decline in muscle mass. Current studies indicate that skeletal muscle atrophy is closely associated with an imbalance between protein synthesis and degradation, driven by multiple factors such as inflammation, oxidative stress, autophagy, and apoptosis [1-3]. Due to the complexity of its molecular mechanisms, effective therapeutic strategies are lacking, and traditional approaches like rehabilitation training and pharmacological interventions show limited efficacy. Therefore, exploring more effective treatments is imperative. Stem cell therapy, with its unique regenerative potential and immunomodulatory properties, offers a promising avenue for treating this condition. In the current issue of the World Journal of Stem Cells, Ying-Jie Wang and colleagues published a review titled "Stem Cell Therapy: A Promising Therapeutic Approach for Skeletal Muscle Atrophy." The article summarizes the molecular mechanisms of muscle atrophy and highlights the applications of mesenchymal stem cells (MSCs), induced pluripotent stem cells (iPSCs), and their derivatives (e.g., exosomes) in treating skeletal muscle atrophy. These stem cells exert therapeutic effects by modulating inflammation, promoting angiogenesis, suppressing oxidative stress, and facilitating muscle regeneration. The authors also address challenges in clinical translation, including immune rejection, tumorigenic risks, inefficient stem cell homing, and the absence of standardized protocols. Despite these hurdles, the review expresses optimism about the future of stem cell therapy, particularly emphasizing the superior potential of stem cell-derived acellular therapies (e.g., exosomes) over traditional cell transplantation. We maintain a cautiously optimistic view regarding the prospects of stem cell therapy for skeletal muscle atrophy. While stem cell-based approaches, especially MSC- and exosome-based strategies, demonstrate promising safety and efficacy [4, 5], several issues must be resolved. These include addressing heterogeneity in stem cell sources, ensuring long-term safety, and establishing standardized protocols for clinical translation. Although iPSCs circumvent ethical concerns, their differentiation and purification techniques require optimization, and potential genetic mutations remain a concern. Exosomes, as acellular therapeutics, may reduce immune reactions; however, challenges in large-scale production and quality control persist. Therapeutic Potential of Stem Cells Stem cell therapy exhibits multidimensional potential in treating muscle atrophy. First, its mechanisms are highly synergistic: MSCs and iPSCs improve the muscle microenvironment by regulating inflammatory cytokines (e.g., suppressing IL-6 and TNF-α), promoting angiogenesis, inhibiting oxidative stress, and enhancing autophagy. Exosomes further amplify therapeutic effects by delivering functional miRNAs (e.g., miR-132-3p/FoxO3 axis) to delay protein degradation and stimulate regeneration [4, 6]. Second, exosomes as acellular carriers broaden clinical applicability: MSC-derived exosomes (e.g., hUC-MSC-Exos, ADSC-Exos) avoid immune rejection and tumorigenic risks associated with live cell transplantation. Their high biocompatibility and cargo of bioactive molecules (e.g., circHIPK3, AMPK/ULK1 regulators) enable targeted intervention in diabetes- or neuropathy-related atrophy, positioning them as pivotal tools for clinical translation [6, 7]. Third, iPSCs hold exceptional promise for personalized medicine. Their ability to differentiate into myogenic progenitor cells (MPCs) or motor neurons facilitates the reconstruction of neuromuscular junctions, offering precise repair for genetic atrophy (e.g., facioscapulohumeral muscular dystrophy, FSHD). While autologous iPSCs mitigate immune rejection, clinical application demands improved differentiation efficiency and safety [8, 9]. Current Challenges and Solutions Clinical translation of stem cell therapy faces multiple challenges requiring innovative solutions. First, heterogeneity and standardization: MSC efficacy varies with donor age, tissue source (e.g., bone marrow, adipose, umbilical cord), and culture conditions [10]. Establishing unified quality control standards—via surface marker screening, secretome profiling, and single-cell sequencing—is critical to identify functional subpopulations and enable precision manufacturing [11]. Second, genetic instability and differentiation inefficiency hinder iPSC applications: reprogramming-induced mutations and inconsistent differentiation protocols (transgene-dependent or -independent) limit reliability [12]. Integrating non-integrative methods (e.g., mRNA reprogramming) and 3D organoid culture systems may optimize differentiation pathways [8]. Third, exosome scalability and targeting: natural exosomes suffer from low bioactive content and short half-lives. Engineering strategies (e.g., ligand modification or drug loading) can enhance tissue-specific delivery [13, 14], while microfluidic-nanocarrier systems may resolve production bottlenecks. Finally, accelerating clinical translation: preclinical studies predominantly rely on animal models; multicenter trials are needed to validate long-term safety (e.g., tumorigenicity, immune tolerance) [15, 16]. Combining stem cell therapy with anti-inflammatory agents (e.g., IL-1β inhibitors), rehabilitation, or gene editing (e.g., CRISPR-Cas9) may synergistically enhance efficacy [17, 18]. Future Directions Future research should prioritize interdisciplinary integration and precision strategies. First, mechanistic insights: single-cell and spatial transcriptomics can unravel dynamic interactions between stem cells and the muscle microenvironment (e.g., satellite cells, macrophages), identifying key regulatory nodes (e.g., Wnt/β-catenin, PI3K/Akt pathways) [3, 19]. Second, biomaterial innovations: smart hydrogels or electroconductive scaffolds combined with localized stem cell/exosome delivery systems could enhance homing efficiency and functional persistence [20, 21]. Third, personalized approaches: tailored therapies based on disease-specific etiologies (e.g., ALS, diabetic atrophy) and molecular subtypes (e.g., inflammatory signatures) are essential. For instance, AMPK-activated umbilical cord MSCs may rectify metabolic dysregulation in diabetic atrophy [22, 23]. Lastly, ethical and regulatory frameworks: international guidelines must standardize stem cell therapies and clarify regulatory classifications (e.g., exosomes as "drugs") to accelerate clinical translation. Stem cell therapy for skeletal muscle atrophy is transitioning from bench to bedside, yet critical hurdles—standardization, safety, and efficacy validation—remain. Integrating multidisciplinary technologies (e.g., synthetic biology, bioinformatics) and advancing translational research will bridge the gap between "laboratory breakthroughs" and "patient benefits." References: 1. Zhang, H., et al., Oxidative stress: Roles in skeletal muscle atrophy. Biochem Pharmacol, 2023. 214: p. 115664. 2. Ji, Y., et al., Inflammation: Roles in Skeletal Muscle Atrophy. Antioxidants (Basel), 2022. 11(9). 3. Liang, W., et al., Epigenetic control of skeletal muscle atrophy. Cell Mol Biol Lett, 2024. 29(1): p. 99. 4. Huang, Z., et al., Skeletal Muscle Atrophy Was Alleviated by Salidroside Through Suppressing Oxidative Stress and Inflammation During Denervation. Front Pharmacol, 2019. 10: p. 997. 5. Song, J., et al., Mesenchymal stromal cells ameliorate diabetes-induced muscle atrophy through exosomes by enhancing AMPK/ULK1-mediated autophagy. J Cachexia Sarcopenia Muscle, 2023. 14(2): p. 915-929. 6. Archacka, K., et al., Hypoxia preconditioned bone marrow-derived mesenchymal stromal/stem cells enhance myoblast fusion and skeletal muscle regeneration. Stem Cell Res Ther, 2021. 12(1): p. 448. 7. Leong, J., et al., Surface Tethering of Inflammation-Modulatory Nanostimulators to Stem Cells for Ischemic Muscle Repair. ACS Nano, 2020. 14(5): p. 5298-5313. 8. Kim, H., et al., Genomic Safe Harbor Expression of PAX7 for the Generation of Engraftable Myogenic Progenitors. Stem Cell Reports, 2021. 16(1): p. 10-19. 9. Azzag, K., et al., Transplantation of PSC-derived myogenic progenitors counteracts disease phenotypes in FSHD mice. NPJ Regen Med, 2022. 7(1): p. 43. 10. Li, J., et al., The heterogeneity of mesenchymal stem cells: an important issue to be addressed in cell therapy. Stem Cell Res Ther, 2023. 14(1): p. 381. 11. Oguma, Y., et al., Single-cell RNA sequencing reveals different signatures of mesenchymal stromal cell pluripotent-like and multipotent populations. iScience, 2022. 25(11): p. 105395. 12. Shamsian, A., et al., Cancer cells as a new source of induced pluripotent stem cells. Stem Cell Res Ther, 2022. 13(1): p. 459. 13. Rezaie, J., et al., Mesenchymal stem cells derived extracellular vesicles: A promising nanomedicine for drug delivery system. Biochem Pharmacol, 2022. 203: p. 115167. 14. Yang, Q., et al., Exosomes-loaded electroconductive nerve dressing for nerve regeneration and pain relief against diabetic peripheral nerve injury. Bioact Mater, 2023. 26: p. 194-215. 15. Drela, K., et al., Experimental Strategies of Mesenchymal Stem Cell Propagation: Adverse Events and Potential Risk of Functional Changes. Stem Cells Int, 2019. 2019: p. 7012692. 16. Deuse, T., et al., Hypoimmunogenic derivatives of induced pluripotent stem cells evade immune rejection in fully immunocompetent allogeneic recipients. Nat Biotechnol, 2019. 37(3): p. 252-258. 17. Iyer, S.R., et al., Exosomes Isolated From Platelet-Rich Plasma and Mesenchymal Stem Cells Promote Recovery of Function After Muscle Injury. Am J Sports Med, 2020. 48(9): p. 2277-2286. 18. Chang, M., et al., Duchenne muscular dystrophy: pathogenesis and promising therapies. J Neurol, 2023. 270(8): p. 3733-3749. 19. Sartori, R., V. Romanello, and M. Sandri, Mechanisms of muscle atrophy and hypertrophy: implications in health and disease. Nat Commun, 2021. 12(1): p. 330. 20. Luo, W., et al., Biomaterials-Based Technologies in Skeletal Muscle Tissue Engineering. Adv Healthc Mater, 2024. 13(18): p. e2304196. 21. Shan, Y., et al., Pharmacokinetic characteristics of mesenchymal stem cells in translational challenges. Signal Transduct Target Ther, 2024. 9(1): p. 242. 22. Shen, Y., et al., Diabetic Muscular Atrophy: Molecular Mechanisms and Promising Therapies. Front Endocrinol (Lausanne), 2022. 13: p. 917113. 23. Yeo, C.J.J., E.F. Tizzano, and B.T. Darras, Challenges and opportunities in spinal muscular atrophy therapeutics. Lancet Neurol, 2024. 23(2): p. 205-218. "
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Wang YJ, Chen ZH, Shen YT, Wang KX, Han YM, Zhang C, Yang XM, Chen BQ. Stem cell therapy: A promising therapeutic approach for skeletal muscle atrophy. World J Stem Cells 2025; 17(2): 98693
14
"Top-down therapy for Crohn's disease (CD) involves starting with the most potent medications, such as biologics and immunomodulators, ..."
[Read more]
"Top-down therapy for Crohn's disease (CD) involves starting with the most potent medications, such as biologics and immunomodulators, immediately after early diagnosis. This strategy may lead to rapid induction of remission, promotion of mucosal healing, prevention of complications, and reduced need for surgery. However, the background factors influencing this top-down therapy have not been sufficiently examined. A recent report on a Japanese cohort found that factors significantly associated with the recent top-down treatment approach were male gender, perianal lesions, no immunomodulators, and anti-tumor necrosis factor therapy. (Miyoshi J, Yoon A, Matsuura M, Hisamatsu T. Real-world use of biologics during the first year of treatment for newly diagnosed Crohn's disease in Japan: a claims analysis from 2010 to 2021. Intest Res. 2025 [PMID: 39848334 DOI: 10.5217/ir.2024.00082]) Top-down therapy for CD should be considered case-by-case, weighing potential benefits against risks and costs. As the authors suggest, identifying patients with a high genetic predisposition for CD may help predict their response to medications, the risk of side effects, and the cost-effectiveness. Further investigation in this area is desirable. "
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Fan YH, Wang MW, Gao YN, Li WM, Jiao Y. Genetic and environmental factors influencing Crohn’s disease. World J Gastrointest Surg 2025; 17(3): 98526
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"Suggested Title:From Weakness to Wellness: The Role of Stem Cells in Muscle Atrophy Recovery A. Clarity and Conciseness • Some ..."
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"Suggested Title:From Weakness to Wellness: The Role of Stem Cells in Muscle Atrophy Recovery A. Clarity and Conciseness • Some sections, particularly those on molecular mechanisms, are dense and could benefit from simplification or restructuring. B. Novelty and Critical Analysis • The review summarizes existing knowledge well but lacks critical analysis of conflicting findings. • Consider discussing limitations of existing studies, such as sample size issues in preclinical models, potential biases, and reproducibility concerns. • More emphasis could be placed on recent breakthroughs or innovative approaches in stem cell therapy, particularly in clinical trials. C. Clinical Relevance and Future Directions • The discussion of clinical applications is somewhat broad. It would be beneficial to include: o Specific ongoing clinical trials (if available). o A comparison of animal models vs. human studies to highlight translational challenges. • The challenges section should offer potential solutions or strategies to overcome issues like immune rejection, tumorigenicity, and ethical concerns. D. Specific Suggestions for Improvement • Introduction: Emphasize the gap in current treatments that stem cell therapy aims to address. • Current Treatment Strategies: Compare rehabilitation and pharmacological treatments with stem cell therapy in terms of: Efficacy, Limitations, Side effects. • Exosome Therapy: This part is well-detailed, but it could benefit from a discussion on manufacturing challenges and standardization issues for clinical application. • Conclusion: Strengthen the future perspectives by suggesting research directions or potential improvements in stem cell delivery methods. "
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Wang YJ, Chen ZH, Shen YT, Wang KX, Han YM, Zhang C, Yang XM, Chen BQ. Stem cell therapy: A promising therapeutic approach for skeletal muscle atrophy. World J Stem Cells 2025; 17(2): 98693
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"This review presents a comprehensive analysis of the role of Traditional Chinese Medicine (TCM) in the treatment of chronic atrophic ..."
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"This review presents a comprehensive analysis of the role of Traditional Chinese Medicine (TCM) in the treatment of chronic atrophic gastritis (CAG), highlighting its multi-targeted therapeutic effects, including gastric mucosal protection, modulation of inflammatory responses, and improvement of microcirculation. The discussion is well-supported by clinical studies and meta-analyses, underscoring the potential benefits of specific herbal compounds such as berberine, morroniside, and notoginsenoside R1. However, the review also acknowledges a key challenge—the lack of standardized research methodologies and evaluation criteria, which limits the broader clinical application of TCM. While the evidence presented suggests promising therapeutic effects, future research should focus on large-scale randomized controlled trials to further validate these findings and establish consistent guidelines for integrating TCM into mainstream gastroenterology practice. Additionally, a more detailed discussion on potential interactions between TCM and conventional Western therapies would strengthen the clinical relevance of this review. Overall, this article makes a valuable contribution to the understanding of CAG management and provides a strong foundation for future research in this field. "
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Wang L, Lian YJ, Dong JS, Liu MK, Liu HL, Cao ZM, Wang QN, Lyu WL, Bai YN. Traditional Chinese medicine for chronic atrophic gastritis: Efficacy, mechanisms and targets. World J Gastroenterol 2025; 31(9): 102053
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"The study by Real Martinez et al. provides valuable insights into the role of circulating myokines such as irisin and FGF21 in MASLD, ..."
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"The study by Real Martinez et al. provides valuable insights into the role of circulating myokines such as irisin and FGF21 in MASLD, particularly their association with severe steatosis and advanced liver fibrosis. However, the absence of a relationship between skeletal muscle alterations (SMAs) and liver fibrosis stages raises intriguing questions. Could the lack of association be attributed to the heterogeneity of the cohort, or might it suggest that SMAs play a more indirect role in MASLD progression? Additionally, how might other metabolic or inflammatory pathways, not directly evaluated in this study, influence the interplay between muscle health and liver disease? Further studies exploring these aspects, especially in longitudinal designs or larger cohorts, would be invaluable in clarifying these relationships and their implications for clinical practice. "
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Real Martinez Y, Fernandez-Garcia CE, Fuertes-Yebra E, Calvo Soto M, Berlana A, Barrios V, Caldas M, Gonzalez Moreno L, Garcia-Buey L, Molina Baena B, Sampedro-Nuñez M, Beceiro MJ, García-Monzón C, González-Rodríguez Á. Assessment of skeletal muscle alterations and circulating myokines in metabolic dysfunction-associated steatotic liver disease: A cross-sectional study. World J Gastroenterol 2025; 31(7): 100039
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"I congratulate the authors for the publication of their write up. It is well written with practical points. The information on greater ..."
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"I congratulate the authors for the publication of their write up. It is well written with practical points. The information on greater likelihood of antibody generation with premixed insulins was new to me, although I believe it would have been partly due to the highly prevalent use of this form of insulin. I would like the authors to understand this point as well while promoting the advantages of the newer insulins. In the international guidelines, at diagnosis of diabetes if the blood glucose levels are above 300 mg/dl and/or glycosylated hemoglobin level is more than 10 %, it is suggested to start the patient on insulin to reduce the glucotoxicity. Once the blood glucose levels reduce, say after 2-3 weeks, the patient may be switched to oral anti-diabetic agents. Such a guideline recommended practice is regularly followed in developing countries such as ours. In such a situation I have observed that the acceptance rate of premixed insulin which involves two pricks, is a lot better than that of multiple short acting insulin doses along with basal insulin. Since the duration of premixed insulin therapy in this context is short, the possible side effects of anti-insulin antibody generation as well as lipodystrophy are less likely. "
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Xia Y, Hu Y, Ma JH. Premixed insulin: Advantages, disadvantages, and future. World J Diabetes 2025; 16(3): 102526
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"This study presents an evaluation of a novel contrast-enhanced catheter with a chamfered tip. Achieving selective biliary cannulation ..."
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"This study presents an evaluation of a novel contrast-enhanced catheter with a chamfered tip. Achieving selective biliary cannulation is one of the most challenging endoscopic maneuver. We congratulate the authors on demonstrating in this paper that a novel device granted higher rates of biliary cannulation when retrospectively compared to a standard sphincterotome. However, a few points warrant further discussion: 1. Generalizability: As a single-center retrospective study, the external validity of these findings could be enhanced with multicenter randomized trials. Variations in patient populations, procedural techniques, and institutional expertise might influence outcomes. 2. Non-expert outcomes: The results indicate a lack of significant improvement in outcomes among non-experts or trainees using the novel catheter. This suggests the device's utility may be contingent on the operator's skill. We also noticed that the expert performed procedure percentage was slightly higher (57% vs 50%) in the novel cathether group, and, although not statistically significant, this could explain the lower use of advanced or rescue cannulation techniques. 3. Adverse Events (AEs): While the overall AE rates were low and comparable between groups, the trend toward fewer cases of PEP with the novel catheter merits closer scrutiny in larger cohorts as this could be an advantage in patients at risk for PEP. On the other hand, the non-statistically significant difference between the two groups in PEP incidence suggests us that the device used to achieve initial selective cannulation maybe isn’t that relevant in increasing PEP risk or incidence, but this should be confirmed in larger studies. 4. Cost-effectiveness: Although not discussed, evaluating the cost implications of adopting this catheter, including potential savings from reduced reliance on rescue techniques and decreased procedural times, would be beneficial for broader clinical adoption. We should also think of the negative aspects: for example, like stone clearance, achieving cannulation with a catheter would require a subsequent switch to a sphincterotome, increasing procedure length and costs, as you would be using two devices instead of one to achieve cannulation. 5. Papilla characteristics: we noticed that in the baseline characteristics intradiverticular papillas and oral oriented papillas were less represented in the catheter group. These types of papilla could benefit of the angling capabilities of a sphincterotome, so this could be a bias that needs to be furthermore cleared. In our experience the angling capabilities of a sphincterotome are crucial in achieving bile duct cannulation in difficult situations. 6. Malignant disease: we do know that malignant diseases (e.g. pancreatic cancer) affecting the ampullar area negatively affect rates of cannulation and increase the need for rescue or advanced techniques of cannulation. This point could have been furthermore discussed by making a distinction between cannulation failures in the setting of benign vs. malignant disease in both groups. In conclusion, this study gives us valuable insights into advancing ERCP outcomes through innovative device design. We must experiment with more designs to compare results and finally choose the best device for cannulation in unexpected and difficult anatomies. "
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Kaneko T, Kida M, Kurosu T, Kitahara G, Koyama S, Nomura N, Tahara K, Kusano C. Outcomes of bile duct cannulation using a novel contrast-enhanced catheter: A single-center, retrospective cohort study. World J Gastrointest Endosc 2025; 17(1): 97840
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"As a colorectal surgeon interested in colorectal cancer and the microbiome, I found this study highly relevant. The authors ..."
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"As a colorectal surgeon interested in colorectal cancer and the microbiome, I found this study highly relevant. The authors effectively highlight differences in mucosa-associated colonic microbiota between colorectal cancer (CRC) and non-CRC patients in Indonesia. A key strength is the focus on mucosal rather than fecal microbiota, providing a clearer picture of the tumor microenvironment. The use of 16S rRNA sequencing with Oxford Nanopore Technologies enables detailed bacterial diversity analysis at the genus and species levels. The study confirms the increased presence of Fusobacterium nucleatum and Bacteroides fragilis in CRC patients, supporting the link between microbial dysbiosis and carcinogenesis. The diagnostic potential of these bacterial markers is particularly noteworthy. Further research with larger sample sizes and functional analyses, such as metagenomics or metabolomics, would enhance understanding of microbiota’s role in CRC. Additionally, while this study offers important insights for Asia, global research is needed to assess regional differences and their impact on CRC diagnostics and treatment. "
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Darnindro N, Abdullah M, Sukartini N, Rumende CM, Pitarini A, Nursyirwan SA, Fauzi A, Makmun D, Nelwan EJ, Shatri H, Rinaldi I, Tanadi C. Differences in diversity and composition of mucosa-associated colonic microbiota in colorectal cancer and non-colorectal cancer in Indonesia. World J Gastroenterol 2025; 31(7): 100051
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