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841 items Read more >>
1
"As both an author and a reviewer for World Journal of Diabetes, I am very grateful for the efficient editorial process and professional ..."
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"As both an author and a reviewer for World Journal of Diabetes, I am very grateful for the efficient editorial process and professional communication. I have two very small, personal suggestions that you may consider for future development of the journal: 1. Website internationalization: To further enhance the journal’s international visibility and accessibility for non-Chinese readers, you might consider moving towards a fully English user interface (or an easily switchable full-English version) for the journal website. I believe this would make it even more convenient for international authors, reviewers, and readers to navigate and submit manuscripts. 2. Print layout and visual style (purely aesthetic): From a purely personal and aesthetic point of view, the printed layout could perhaps be made a bit more “minimalist” and academic in style. For example, slightly reducing the use of large areas of bright orange-red tones and making the “WJD” journal label a little smaller might give the printed pages a more understated and refined appearance, while still preserving the journal’s visual identity. These are only minor, personal suggestions. Overall, I am very satisfied with my publishing experience with WJD and sincerely appreciate the efforts of the editorial and production team. "
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Guo YL, Niu WJ, Jiao HR, Li YP, Xu C, Zhou X, Wang J. Crosstalk between oxidative stress and inflammatory pathways: Natural therapeutic approaches for diabetic wound healing. World J Diabetes 2025; 16(11): 111400
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"I am extremely satisfied with the entire submission process of my recent manuscript to World Journal of Gastrointestinal Endoscopy. ..."
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"I am extremely satisfied with the entire submission process of my recent manuscript to World Journal of Gastrointestinal Endoscopy. From the initial online submission to the prompt peer review feedback, and from the careful editorial revisions to the smooth final publication, every step was handled professionally, efficiently, and transparently. The editors and reviewers provided valuable, constructive comments that not only improved the quality of my paper but also deepened my understanding of the research field. I sincerely wish your journal continued success and further development, with its SCI impact factor rising steadily to attract more high-quality research from global scholars. I have already recommended your journal to several of my colleagues due to my positive experience, and I eagerly look forward to submitting my future research findings to your journal, hoping they will be favorably received and published. Thank you again for the excellent service and support throughout the process! "
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Li F, Xie YL, Xu D, Lu CH, Wu JW, Ma JX, Guan GX, Wang HX. Comparison of different anastomosis methods in laparoscopically assisted left hemicolectomy for colon cancer. World J Gastrointest Endosc 2025; 17(11): 111117
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"We would like to express our sincere gratitude to the editor and reviewers for their valuable comments and constructive feedback ..."
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"We would like to express our sincere gratitude to the editor and reviewers for their valuable comments and constructive feedback throughout the review process. We appreciate the editor’s professional handling and guidance throughout the review process. We truly appreciate the opportunity to publish our work in your esteemed journal. We hope that our findings will contribute to further discussions and future developments in this research area. Sincerely, Shoko Sagawa "
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Sagawa S, Ito F, Nakatani M, Kurose S, Niiro E, Taniguchi M, Toyoda S, Sado T, Morita K. Mesonephric-like adenocarcinoma presenting with malignant peritonitis and suspected to originate from the fallopian tube: A case report. World J Clin Cases 2025; 13(32): 110813
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"My experience publishing in the World Journal of Psychiatry has been exceptionally positive, and I highly recommend it to clinical ..."
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"My experience publishing in the World Journal of Psychiatry has been exceptionally positive, and I highly recommend it to clinical psychiatric researchers! The entire process from submission to online publication was efficient and smooth, perfectly aligning with the timelines required for promotion evaluations or project closures. The editorial team was highly responsive, addressing all inquiries promptly. Their thorough understanding of global psychiatric research trends ensured seamless communication, even for non-native English speakers. Reviewers’ comments were constructive and clinically relevant, emphasizing practical value rather than overly demanding groundbreaking findings. Minor revision suggestions were specific and actionable, with the acceptance notice received shortly after resubmission. Boasting a transparent peer-review process and a strong focus on real-world clinical significance, this journal strikes an excellent balance between academic rigor and accessibility. I have already recommended it to many colleagues in my department! "
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Guo L, He LX, Wan PQ, Zhen XM, Xiao F, Wu WB, Su MH, Gao BH, Liu ZH. Meta-analysis of factors associated with the incidence of comorbid depression and anxiety in patients with chronic hepatitis B. World J Psychiatry 2025; 15(11): 106164
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"Resp sir/madam, World J Gastrointest Oncol Peer review is vitally important to uphold the high standards of scholarly communications, ..."
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"Resp sir/madam, World J Gastrointest Oncol Peer review is vitally important to uphold the high standards of scholarly communications, and maintain the quality of individual article. It is also an important support for the researchers/ authors the articles.The feedback from reviewers and editors are used to improve our paper before it is published. These have clarity, constructiveness, and helpfulness.Quality is for the result of high intention, sincere effort, intelligent direction and skillful execution to improve the research.Thank you, for our article to publishied in WJGO. "
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Jagtap SV, Jagtap SS. Evaluation of pancreatic adenocarcinoma with tumor budding and lymphocytic infiltration as prognostic marker. World J Gastrointest Oncol 2025; 17(11): 110798
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"The submission process was exceptionally smooth and yielded results that exceeded our expectations. We were profoundly impressed by ..."
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"The submission process was exceptionally smooth and yielded results that exceeded our expectations. We were profoundly impressed by the publisher's outstanding editorial team and their panel of highly experienced review experts, whose professionalism and meticulous approach are truly commendable. Furthermore, it is particularly noteworthy that the entire process, from manuscript acceptance to final publication, strictly adhered to the established timeline. The remarkable execution efficiency fully demonstrated their superior project management capabilities. "
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Liu XR, Chen XZ, Fan MW, Zhang SH, Shi N, Liu CX, Chen Y, Wang XM. Endoscopic treatment for dysphagia caused by mid-esophageal diverticulum and diffuse esophageal spasm: A case report. World J Gastrointest Endosc 2025; 17(11): 111770
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"We are really happy to publish our work in the World Journal of Orthopedics. The review process was efficient and fast. The suggestions ..."
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"We are really happy to publish our work in the World Journal of Orthopedics. The review process was efficient and fast. The suggestions of external reviewer greatly improved the quality of our manuscript. The editing team was also efficient and great. We appreciate the timely reminder emails that were sent to us at various points. If there is any new manuscript, we will also submit it to this journal. "
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He WP, Ren CM, Luo F, Chen L, Wang WT, Qiu BT, Zhang XC, Chen HT. Bilateral sleeve fracture of the superior pole of the patella in a healthy adult: A case report. World J Orthop 2025; 16(11): 110173
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"The review process was efficient, and peer review experts provided professional and constructive revisions. In order to ensure the ..."
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"The review process was efficient, and peer review experts provided professional and constructive revisions. In order to ensure the high quality of the final published results, the author team revised the manuscript carefully and carefully for several rounds. The submission system is easy to operate, the charts after publication are high definition, and the reference format is concise and clear, which significantly improves the reading experience of readers. I would like to express my sincere thanks to the editorial department and the reviewers. "
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Zheng SW, Lin XY, Xie NS, Zhang XY, Deng F, Zou HQ, Zhan XL, Tang GY. Breastfeeding was associated with lower risks of maternal postpartum hypertension and diabetes mellitus: A systematic review and meta-analysis. World J Diabetes 2025; 16(11): 111578
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"Our experience publishing with the World Journal of Orthopedics was highly positive. The journal's dedicated language service greatly ..."
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"Our experience publishing with the World Journal of Orthopedics was highly positive. The journal's dedicated language service greatly improved our manuscript's clarity and compliance. We are particularly grateful to the reviewers for their expert and insightful comments, which were pivotal in strengthening the academic rigor and depth of our work. We are delighted with the final outcome and confident in the contribution this makes to our field. "
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Huang HC, Che YF, Sun H, Xu YS, Gao HY, Tang XS. Traditional Chinese bone-setting combined with percutaneous screw fixation for comminuted calcaneal fractures: A case report and review of literature. World J Orthop 2025; 16(11): 111052
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"The peer-review process was rigorous yet constructive. Both reviewers read our methodology in detail, pointed out the problem of our ..."
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"The peer-review process was rigorous yet constructive. Both reviewers read our methodology in detail, pointed out the problem of our statistical methods and suggested a larger-scale study. The editorial team required two rounds of revision within a specific time, giving clear check-lists. Such in-depth, prompt feedback significantly improved the efficiency. "
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Jin T, Zhou YW, Sun PS, Huang Y, Gao JG, Jin X. Unraveling the characteristics of early esophageal neuroendocrine carcinoma using multi-model endoscopy: A retrospective study of serial cases. World J Gastrointest Oncol 2025; 17(11): 110715
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"The publication process for the Letter to the Editor in the World Journal of Diabetes was a relatively quick and streamlined process, ..."
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"The publication process for the Letter to the Editor in the World Journal of Diabetes was a relatively quick and streamlined process, from the time of submission to the publication date. We are very satisfied with the quality of peer review as well as the quality of editing undertaken for this Letter to the Editor by the World Journal of Diabetes. There were no issues encountered throughout the publication process. "
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Jiang H, Henley D, Jiang FX. Potentially novel surrogate biomarker for diagnosing insulin resistance in type 2 diabetes. World J Diabetes 2025; 16(11): 113457
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"Re: Kanda T, Sasaki-Tanaka R, Kamimura H, Terai S. Is higher body mass index correlated with worse clinical outcomes in acute liver ..."
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"Re: Kanda T, Sasaki-Tanaka R, Kamimura H, Terai S. Is higher body mass index correlated with worse clinical outcomes in acute liver failure? World J Clin Cases 2025; 13(32): 113514 [DOI: 10.12998/wjcc.v13.i32.113514] It is my great pleasure to publish our article in World Journal of Clinical Cases as a Letter to the Editor of an invited article. Our article entitled "Is higher body mass index correlated with worse clinical outcomes in acute liver failure?" is comments on the article "Krishnan A, Khan S, Gips J, Alqahtani SA, Vaidya D, Liu YS, Kim A, Su A, Gurakar A, Hamilton JP, Woreta TA. Body mass index and its association with clinical outcomes in acute liver failure. World J Clin Cases. 2025;13:109212." We also published "Kanda T, Yokosuka O, Hiraide A, Kojima H, Honda A, Fukai K, Imazeki F, Nagao K, Saisho H. Prevalence of obesity in patients with acute hepatitis; is severe obesity a risk factor for fulminant hepatitis in Japan? Hepatogastroenterology. 2005;52:180-182. " before. Thank you. Best, Tatsuo Kanda, M.D. "
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Kanda T, Sasaki-Tanaka R, Kamimura H, Terai S. Is higher body mass index correlated with worse clinical outcomes in acute liver failure? World J Clin Cases 2025; 13(32): 113514
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"I am thoroughly impressed with the efficiency and fairness of the publication process. The peer review process was not only helpful ..."
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"I am thoroughly impressed with the efficiency and fairness of the publication process. The peer review process was not only helpful but also insightful, providing constructive feedback that significantly enhanced the quality of my work. The support from the editorial team was exceptional. They maintained clear and timely communication, keeping me informed of each stage in the publication process, which I greatly appreciated. This level of professionalism and dedication made the entire experience smooth and rewarding. Thank you for the substantial support and guidance throughout "
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Kassem S, Khalaila B, Stein N, Zaina A. Glucagon-like peptide 1 receptor agonists switching patterns in type two diabetes: A retrospective real-world study. World J Diabetes 2025; 16(11): 112999
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"I think the process was smooth and efficient. I am happy to be a reviewer with your journal in the future. The time spent from ..."
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"I think the process was smooth and efficient. I am happy to be a reviewer with your journal in the future. The time spent from acceptance to publishing was acceptable. I was able to communicate with journal and get a response within reasonable time but sometimes take longer. Otherwise, no issues! "
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Anam E. Shoulder complications in sickle cell disease: Challenges, management strategies, and future directions. World J Orthop 2025; 16(11): 112198
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"I am satisfied with the process of publishing manuscript. It is my honor to submit my manuscript to your journal， and I am grateful ..."
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"I am satisfied with the process of publishing manuscript. It is my honor to submit my manuscript to your journal， and I am grateful for editors and peer review professors giving me the revising suggestions. Then， if there is any new manuscript，I will also submit it to your journal. I am satisfied with the process of publishing manuscript. It is my honor to submit my manuscript to your journal， and I am grateful for editors and peer review professors giving me the revising suggestions. Then， if there is any new manuscript，I will also submit it to your journal. "
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Yu JH, Yu J, Yu JX, Yang LF, Yan D, Liu Y, Xian JR, Yi PS. Personalized prognosis in unresectable hepatocellular carcinoma: Development and validation of a model for transcatheter arterial chemoembolization plus lenvatinib. World J Gastrointest Oncol 2025; 17(11): 111814
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"Some of the article’s reviewers are particularly clear, offering targeted comments and providing solutions, while others are vague, ..."
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"Some of the article’s reviewers are particularly clear, offering targeted comments and providing solutions, while others are vague, writing comments merely to fill sentences. They also mention certain issues in the manuscript which the authors have already pointed out cannot be addressed, yet they still record them. However, there are reviewers who both make pertinent observations and propose solutions to help the authors get their article accepted. I believe it would be advisable to recommend that reviewers provide to-the-point comments and suggest practical solutions for the authors. Furthermore, while your journal invites certain authors whose work it considers noteworthy to submit a manuscript for review—explicitly assuring them that no fees will be charged—you ultimately impose conditions at the end of the process, even after the article has been accepted, that require authors to pay money. One such example is the requirement for “necessary language improvements,” even when this is objectively unnecessary, especially in cases where the author group includes physicians who are native English citizens and the have CV with 100-400 papers in the PubMed. This should not happen, as it discourages authors from submitting their work to your journal. It makes us feel misled as an author group and suggests that our integrity is being questioned. When your journal states that no publication fee will be required, this should apply to all aspects of the process. If the journal truly wishes to support selected submissions, it should also assume any associated costs rather than indirectly obliging the authors to pay for services that are ultimately unnecessary. We kindly ask you to compare the final version of our manuscript—the one we originally submitted—with the version produced after the $850 payment, and examine the level of English language quality, grammar, and syntax, which was already of the highest standard. Thank you for your understanding. "
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Tzouvala M, Zacharopoulou E, Kalafateli M, Viazis N, Psistakis A, Theodoropoulou A, Drygiannakis I, Karmiris K, Koutroubakis IE, Kevrekidou P, Soufleris K, Katsaros M, Giouleme O, Fousekis F, Katsanos K, Christodoulou D, Gaki A, Papathanasiou E, Bamias G, Zampeli E, Michopoulos S, Kyriakos N, Veretanos C, Argyriou K, Kapsoritakis A, Tribonias G, Mantzaris GJ, Liatsos C. Value of tofacitinib extended induction therapy in patients with moderate-to-severe ulcerative colitis: A real-world 52-week follow-up study. World J Gastroenterol 2025; 31(42): 111282
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"Most aspects of the publication process is generally satisfactory. However, I was disappointed with the online submission system, ..."
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"Most aspects of the publication process is generally satisfactory. However, I was disappointed with the online submission system, finding it overly complex and instruction-heavy, which made the process more difficult than necessary. Additionally, the article editorial process seems unnecessarily cumbersome and lengthy, which can be discouraging for authors. I hope these concerns can be addressed to improve the overall experience and make it more user-friendly for authors submitting their work. Also worthy of note is the unnecessary word limit given to this particular comment column. "
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Sanusi KO, Asiwe JN, Sulaimon FA, Bashar F, Yusuf SK, Abdulkadir HO. Diabetic neuropathy and wound healing: An update on epigenetic crosstalk. World J Diabetes 2025; 16(11): 110428
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"The whole process of submitting the article was seamless, and the reviewers provided highly professional feedback. These constructive ..."
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"The whole process of submitting the article was seamless, and the reviewers provided highly professional feedback. These constructive comments not only helped me refine the current manuscript but also clarified key standards for academic writing rigor. I gained considerable insights throughout this submission, which will equip me with more practical experience for future manuscript submissions. It would be ideal if the publication cycle could be further shortened. "
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Wu YX, Tian R, Li XW, Guo JY, Tang JF, Zhou CF. Emerging non-invasive imaging biomarkers of Ki-67 in pancreatic cancer: Toward predictive precision oncology. World J Gastrointest Oncol 2025; 17(11): 110468
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"Thank you for the opportunity to submit our manuscript, We believe our work aligns well with the scope of your journal and will be ..."
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"Thank you for the opportunity to submit our manuscript, We believe our work aligns well with the scope of your journal and will be of interest to its readership. We have ensured that the manuscript presents a clear, concise, and reproducible account of our research. We have also thoroughly reviewed the journal's formatting guidelines and believe our submission is fully compliant. We look forward to your valuable feedback and are available to make any revisions you may recommend. "
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Yao ZY, Bao G, Li GC, Hao QL, Ma LJ, Rao YX, Xu K, Ma X, Han ZX. Survival prognosis in advanced HER-2 negative gastric cancer treated with immunochemotherapy: A novel model. World J Gastrointest Oncol 2025; 17(11): 112981
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"I really appreciate the journal for publishing my article. From submission through peer review to publication, the process was ..."
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"I really appreciate the journal for publishing my article. From submission through peer review to publication, the process was efficient and transparent. The reviewers offered professional and constructive feedback, while the editorial team provided prompt and attentive support. I expect that this journal will continue to grow in influence, and I look forward to collaborating in the future. "
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Xiao FG, Yang Z, Yu SY, Li Q, Huang PC, Huang GB, Li XG, Ran JL, Rui SL, Deng WQ. N7-methylguanosine-related gene decapping scavenger enzymes as a novel biomarker regulating epithelial cell function in diabetic foot ulcers. World J Diabetes 2025; 16(11): 109455
19933 items Read more >>
1
"1 Ethics: Not provided
2 Methods: The experimental method is effective and can be repeated by fellow researchers
3 Results ..."
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"1 Ethics: Not provided
2 Methods: The experimental method is effective and can be repeated by fellow researchers
3 Results The theory is validated
4 No figures or tables provided
5 Biostatistics: Not needed
6 References: The author scientifically and reasonably cite the latest references
7 Language: The language in article correctly, clearly and concisely expresses the information
"
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Sameer M, Muthu S, Vadranapu S. Prophylactic fixation in elderly fractures: Preventive breakthrough or unnecessary intervention? World J Orthop 2025; 16(11): 109855
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"In the recent years,the relationship between intestinal flora disorders and various diseasess,especially IBD,has become clear, and ..."
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"In the recent years,the relationship between intestinal flora disorders and various diseasess,especially IBD,has become clear, and fecal transplantation , which aims to improve dysbiosis, has attracted attention.This study also reports on fecal transplantation for the purpose of correcting intestinal flora disorders in IBD,and further research and clinical application are expected in the furture."
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Zheng L, Duan SL, Wang K. Research progress concerning the involvement of the intestinal microbiota in the occurrence and development of inflammatory bowel disease. World J Gastroenterol 2025; 31(42): 113170
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"It was with pleasure that I reviewed the article quality of the following manuscript. Please see my comments below:
1 Ethics: ..."
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"It was with pleasure that I reviewed the article quality of the following manuscript. Please see my comments below:
1 Ethics: Not applicable given manuscript type
2 Methods: Not applicable given manuscript type
3 Results: Not applicable given manuscript type
4 Figures and tables: The tables add to the readability of the manuscript
5 Biostatistics: Not applicable given manuscript type
6 References: References are appropriate/up to date
7 Language: This is a concise/well written manuscript
8 Caveats or drawbacks: None "
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Wang XY, An F, Wang BJ, Han WW. Hydrogen peroxide pathway in ulcerative colitis: Promises and challenges in translating novel pathogenesis to clinical practice. World J Gastroenterol 2025; 31(42): 112566
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"Overall Assessment
1. The letter clearly addresses the association between BMI and clinical outcomes in ALF, which is clinically ..."
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"Overall Assessment
1. The letter clearly addresses the association between BMI and clinical outcomes in ALF, which is clinically relevant.
2. The format follows standard Letter to the Editor conventions, making it easy to read.
3. The discussion is well-supported by Krishnan et al.’s recent study and previous reports (Kanda et al., Rutherford et al.), with accurate citations.
Strengths
1. Highlights a growing concern—obesity and its impact on ALF outcomes.
2. Includes Japanese and U.S. data, showing differences in etiology (acetaminophen vs. non-acetaminophen causes).
3. Emphasizes vigilance for renal failure and hepatic encephalopathy in obese ALF patients.
"
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Kanda T, Sasaki-Tanaka R, Kamimura H, Terai S. Is higher body mass index correlated with worse clinical outcomes in acute liver failure? World J Clin Cases 2025; 13(32): 113514
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"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..."
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"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Kim N, Lee H, Park D. Challenging diagnosis of groove pancreatitis with severe gastric outlet obstruction: A case report. World J Clin Cases 2025; 13(32): 111796
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"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..."
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"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Aisikaer A, Sun MM, Shen J. Positron emission tomography/computed tomography in risk-factor-negative young female with malignant pleural mesothelioma: A case report and review of literature. World J Clin Cases 2025; 13(32): 110897
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"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..."
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"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Liu KT, Lee MH, Lin CH, Tsou YK, Sung KF, Wang SF, Wu CH, Liu NJ. Acute cholangitis due to common bile duct stones: Clinical outcomes in patients with and without concurrent acute pancreatitis. World J Clin Cases 2025; 13(32): 110553
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"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..."
[Read more]
"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Noh BG, Seo HI, Park YM, Oh MH, Song SB. Clinicopathologic differences before and after elective laparoscopic cholecystectomy according to obesity. World J Clin Cases 2025; 13(32): 110391
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"Has authors used low threshold for BMI in this study.This needs attention and could be bias.To apply this , international definition ..."
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"Has authors used low threshold for BMI in this study.This needs attention and could be bias.To apply this , international definition for obesity needs to be included.The study is read by clinicians all over world ans using nonstandardised definition needs to reconsider.
sing a standardized 3-port LC technique.
Using 3 port instead of 4 port in obesity raises alarm over safety keepi in view ergonomics
Intraoperative bile leak in your series seems to be heroic by using 3 port lap chole
"
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Noh BG, Seo HI, Park YM, Oh MH, Song SB. Clinicopathologic differences before and after elective laparoscopic cholecystectomy according to obesity. World J Clin Cases 2025; 13(32): 110391
10
"This case report is highlighting low threshold of Malignancy in groove pancreatitis.A meticolous clinical approach is refeclting in ..."
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"This case report is highlighting low threshold of Malignancy in groove pancreatitis.A meticolous clinical approach is refeclting in this case.Imaging is well giving learning .
Introduction is well evidence based.Case presentation is excellent.Discussion is robust with well coverage of latest updates in literaure.References are latest one
Overall, a case report giving good "Message to take home "
"
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Kim N, Lee H, Park D. Challenging diagnosis of groove pancreatitis with severe gastric outlet obstruction: A case report. World J Clin Cases 2025; 13(32): 111796
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"1. The review provides a thorough and well-organized synthesis of the complex interplay between MASLD and IBD, with a strong emphasis ..."
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"1. The review provides a thorough and well-organized synthesis of the complex interplay between MASLD and IBD, with a strong emphasis on the gut microbiota and the gut-liver axis. The topic is highly relevant, given the rising global prevalence of both MASLD and IBD, and the growing recognition of their co-occurrence. The review successfully highlights the shift from a purely metabolic understanding of MASLD to one that incorporates gut-derived inflammation and dysbiosis, which is a crucial contemporary concept.
2. References：The authors have done an excellent job integrating a vast body of literature, making the manuscript a valuable and up-to-date resource for researchers and clinicians.
3. Language：The manuscript is generally well-written in clear and accessible English, which facilitates the comprehension of complex pathophysiological concepts.
4. Figures and tables：A significant shortcoming is the lack of detailed, mechanistic figures. The existing two figures are overly simplistic and do not adequately illustrate the complex molecular and cellular pathways discussed in the text (e.g., the roles of TLRs, bile acid receptors FXR/TGR5, Th17/Treg imbalance, cytokine networks, and the impact of specific microbial metabolites). I strongly recommend the inclusion of at least one high-quality, multi-panel schematic diagram that visually integrates the key proposed mechanisms linking gut dysbiosis, intestinal barrier dysfunction, immune activation, and hepatic inflammation/fibrosis in the context of IBD-associated MASLD.
5. Caveats or drawbacks：
The manuscript contains several typographical and terminological errors that detract from its professionalism. For instance: On Page 4, the text reads "T17 cells play a key role..." This should be corrected to "Th17 cells..." as this is the standard nomenclature for T-helper 17 cells.
While the content is comprehensive, there is some repetition between sections, particularly regarding the description of gut dysbiosis and its consequences in both IBD and MASLD. The flow could be improved by more sharply differentiating the disease-specific mechanisms before synthesizing them into a unified model. The sections on "Eating Behaviour Patterns" and "Nutrition-Microbiota Axis," while interesting, feel somewhat distinct from the core mechanistic focus and could be more seamlessly integrated.
The treatment section briefly mentions probiotics, synbiotics, and cytokine inhibitors (IL-17/IL-23) but lacks depth in discussing the current evidence base, challenges, and future directions for these interventions.
The review excellently describes associations but could more explicitly acknowledge the challenges in establishing causality within the gut-liver axis in human studies.
In summary, this is a timely, informative, and largely well-executed review that makes a valuable contribution to the literature. Its primary strengths lie in its scholarly comprehensiveness and relevance.
"
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Sokal-Dembowska A, Ergan K, Jarmakiewicz-Czaja S. Role of gut microbiota in the development of metabolic dysfunction-associated steatotic liver disease in inflammatory bowel disease. World J Gastroenterol 2025; 31(40): 111375
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"It is generally accepted that IBD results from the interaction of multiple environmental factors in genetically predisposed ..."
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"It is generally accepted that IBD results from the interaction of multiple environmental factors in genetically predisposed individuals, and that altered intestinal permeability is a key mechanism in the pathogenesis of the disease, as in many other digestive tract pathologies. Mitochondrial dysfunction in the intestinal mucosa is another mechanism involved in the pathogenesis of IBD.
In the reviewed study, the authors examined the factor GDF15, a member of the TGF-β superfamily, as a biomarker of mitochondrial dysfunction and a mediator of UPRmt. The researchers confirmed elevated circulating GDF15 levels in IBD patients compared with healthy controls and identified a novel molecular mechanism by which this cytokine disrupts the intestinal barrier. Therefore, successfully reducing GDF15 may constitute a therapeutic strategy to prevent intestinal barrier breakdown by reducing immune hyperactivation in the future.
All these basic research studies contribute decisively not only to elucidating the pathogenetic mechanisms of IBD but also to developing new therapeutic strategies that bring us closer to the day when we can achieve complete and sustained inhibition of IBD activity."
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Ruiz-Malagón AJ, Herraiz-Vilela M, Serrano-Pino R, García-Ávila P, Díaz- Suárez L, Carmona-Segovia AD, Becerra-Munoz VM, Jiménez-Navarro M, Arranz-Salas I, López-Villodres JA, Fernández-Castañer A, Gutiérrez-Martínez F, Rodríguez-González FJ, Camargo-Camero R, Alcaín-Martínez G, Rodríguez-Díaz C, García-Fuentes E, Sánchez-Quintero MJ, López-Gómez C. Growth differentiation factor 15 alters intestinal barrier and increases permeability: A new molecular target in inflammatory bowel disease. World J Gastroenterol 2025; 31(41): 110955
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"a fine-needle aspiration (FNA) biopsy, especially one guided by endoscopic ultrasound (EUS-FNA), is a valuable diagnostic tool for ..."
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"a fine-needle aspiration (FNA) biopsy, especially one guided by endoscopic ultrasound (EUS-FNA), is a valuable diagnostic tool for pancreatic tuberculosis. This procedure allows doctors to collect tissue samples to confirm the diagnosis by checking for characteristic signs like granulomas, caseous necrosis, and acid-fast bacilli (AFB) or by using polymerase chain reaction (PCR) to detect the DNA of Mycobacterium tuberculosis. EUS-FNA is especially useful because it can help differentiate pancreatic TB from pancreatic cancer, preventing unnecessary surgery. "
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Nima CL, Wang HG, Zhou Q. Pancreatic tuberculosis: A case report and review of literature. World J Gastroenterol 2025; 31(41): 110398
14
"In this mini-review, the authors described the current understanding of the pathogenesis, diagnosis, and management of hepatic ..."
[Read more]
"In this mini-review, the authors described the current understanding of the pathogenesis, diagnosis, and management of hepatic hydrothorax. Despite the successes of modern hepatology, the presence of hepatic hydrothorax is associated with poor prognosis and high mortality. Most patients with hepatic hydrothorax are candidates for liver transplantation. In usual clinical practice, the key to the success of their management may be the stratification of the risk of an adverse outcome and the definition of individual therapeutic tactics. A pathogenetically based approach to the choice of pharmacotherapy, as well as optimization of minimally invasive treatment methods, will improve the quality of life and increase the survival rate of this category of patients. In general, the authors provided well-known information."
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Cilia BJ, Haridy J, Raj A, Hannah N. Hepatic hydrothorax as a manifestation of decompensated cirrhosis: An update on current management and future directions. World J Hepatol 2025; 17(10): 110412
15
"Dear Author
There are parameters like MELD score that show the severity of the disease. This important score was not addressed ..."
[Read more]
"Dear Author
There are parameters like MELD score that show the severity of the disease. This important score was not addressed in the trial. Were the adherent and non-adherent groups had similar MELD scores? Sarcopenia as another important factor that influence cirrhosis out comes. This risk factor was not addressed in this trial. The nutritional status regarding the vitamins and protein intake are among the most important factors that influence cirrhosis out comes. In the future trials considering the variables that influence the patient outcomes should be considered. "
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Loschi TM, Baccan MDTA, Pereira EC, Dellabarba TDLC, Boteon APCS, Boteon YL. Telerehabilitation for frail cirrhotic patients awaiting liver transplant: A safe, effective strategy to improve outcomes. World J Hepatol 2025; 17(10): 110856
16
"Dear Author,
The patient had a history of cirrhosis of the liver based on abdominal CT scan. The data regarding the other causes ..."
[Read more]
"Dear Author,
The patient had a history of cirrhosis of the liver based on abdominal CT scan. The data regarding the other causes of chronic hepatitis were not included in the draft. Although using herbal medicine could cause the fulminant hepatitis, yet it is a diagnosis of exclusion. In my opinion, the possibility of coexistence of auto immune hepatitis in this case needs more evaluation."
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Zhu XY, Zhao YT, Su CS, Yuan XD, Zhang SG, Nashan B. Acute liver failure caused by alkaloids from traditional Chinese medicine: A case report. World J Hepatol 2025; 17(10): 109575
17
"In recent years, artificial intelligence (AI) has brought about a real revolution in various fields of human activity, establishing ..."
[Read more]
"In recent years, artificial intelligence (AI) has brought about a real revolution in various fields of human activity, establishing itself as a pioneering innovation in modern medical science. In the field of gastroenterology, and in particular colonoscopy, it has contributed significantly by promoting key quality indicators, reducing the rate of human error, and improving the consistency of endoscopist decision-making with high reliability. Reduce human error and improve endoscopists' decision-making consistency in real time, ensuring higher reliability and standardization during the procedure. By optimizing the characterization of endoscopically detected lesions, supporting visual diagnosis, and predicting the depth of infiltration, AI can enable early diagnosis and prevention of colon cancer. The combination of AI with advanced imaging techniques improves the quality of gastroenterologists' training.
However, much remains to be clarified regarding the role of AI in upper and lower gastrointestinal endoscopy. I believe that the official gastroenterological societies of Europe, the USA, and Asia should immediately delve into studying and defining the possibilities, potential risks of the widespread application of the method, and define policies regarding quality assurance, clinician education, data protection, and liability, so that AI successfully complements human intelligence and experience. The innate tendency of people (in this case, endoscopists) to resist adopting these new technologies should not prevail. They can also help validate AI systems in real-world conditions by assessing their performance across a wide range of quality indicators.
I want to congratulate the authors for their excellent work in a promising field."
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Dimopoulou K, Spinou M, Ioannou A, Nakou E, Zormpas P, Tribonias G. Artificial intelligence in colonoscopy: Enhancing quality indicators for optimal patient outcomes. World J Gastroenterol 2025; 31(40): 111499
18
"This is very interesting paper.Higher serum gamma-glutamyl transpeptidase (γ-GTP) levels are associated with an increased risk of ..."
[Read more]
"This is very interesting paper.Higher serum gamma-glutamyl transpeptidase (γ-GTP) levels are associated with an increased risk of pancreatic cystic neoplasms (PCNs) and their malignant progression. However, γ-GTP is not a specific diagnostic marker for these conditions. Its elevation is more indicative of general liver or biliary dysfunction and oxidative stress. Recent large-scale studies have found that people with higher baseline serum γ-GTP levels have a significantly increased risk of being diagnosed with PCNs later on. This suggests γ-GTP could potentially serve as a biomarker for identifying high-risk individuals for surveillance."
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Lee MW, Park JM, Cho IR, Chung KH, Kim BS, Choi JH, Paik WH, Ryu JK, Han K, Lee SH. Serum gamma-glutamyl transferase level is associated with the risk of pancreatic cystic neoplasms: A nationwide retrospective cohort study. World J Gastroenterol 2025; 31(40): 110932
19
"Artificial intelligence has brought about a real revolution in various areas of human activities, including medical science. In recent ..."
[Read more]
"Artificial intelligence has brought about a real revolution in various areas of human activities, including medical science. In recent years, AI has also emerged as a method to support the correct diagnosis and treatment of acute pancreatitis. Some elements of AI, such as machine learning, deep learning, natural language processing, and network pharmacology, seem to significantly facilitate diagnostic and therapeutic decisions in the treatment of patients with acute pancreatitis, through the analysis of clinical records, medical images, laboratory values, genomic data, and physiological signals in real time. AI functions as advanced decision support, enhancing clinical judgment with intelligence derived from diagnostic data, assessing risks to the patient from potential complications, and helping safely predict the disease. The authors also discuss future directions for AI development in the treatment of acute pancreatitis. As emphasized by the authors of this review, today's practical medicine often requires an interdisciplinary approach that integrates clinical experience, computational modeling, and ethical design. These largely theoretical data currently have limited application, especially in developing countries worldwide. For all health systems and in any country where AI is applied, its assistance should consist of improving decision-making through hybrid human-artificial intelligence models. The future looks excellent, although it causes concern and fear to the undersigned."
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Zhang XY, Hu MD, Maimaitijiang D, Wang T, Wang L. Artificial intelligence in pancreatitis: A narrative review on advancing precision diagnosis, prognosis, and therapeutic strategies. World J Gastroenterol 2025; 31(39): 110971
20
"This review explores the bidirectional regulation between the gut microbiome and the immune system within the colorectal cancer (CRC) ..."
[Read more]
"This review explores the bidirectional regulation between the gut microbiome and the immune system within the colorectal cancer (CRC) microenvironment. It highlights how microbial metabolites and immune signaling pathways influence tumor progression, immune evasion, and therapeutic response. Key mechanisms include TLR4 and NLRP3 activation, SCFA modulation, and PD-1 pathway interactions. The authors discuss emerging interventions such as engineered probiotics, FMT, and metabolic vaccines targeting the microbiota-immune axis. Overall, the study provides a comprehensive framework for developing personalized CRC therapies through microbiome modulation."
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Liu XX, Yang B, Tang DX. Bidirectional regulation of the gut microbiome-immune axis in the immune microenvironment of colorectal cancer and targeted interventions. World J Gastrointest Oncol 2025; 17(10): 109503
15842 items Read more >>
Peer-Reviewers and Manuscript Statistics
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- Manuscripts received today
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- Reviewer refusals today
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- Total accepted manuscripts
- 38610
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- Total peer-reviewers
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- Total submissions
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1
"The study by Li Lin et al., “Early vs conventional initiation of adjuvant chemotherapy in advanced gastric cancer: A ..."
[Read more]
"The study by Li Lin et al., “Early vs conventional initiation of adjuvant chemotherapy in advanced gastric cancer: A propensity-matched outcomes study,” addresses a clinically relevant question; however, several issues limit the strength and applicability of its conclusions. First, the analysis does not demonstrate any clear advantage of early versus conventional initiation of adjuvant chemotherapy in terms of either overall survival or disease-free survival. A possible benefit is suggested with respect to the rate of peritoneal recurrence, but this signal is difficult to interpret in the absence of any comparison with currently available intraperitoneal treatment strategies. Moreover, the study does not provide robust selection criteria to clearly identify which patients might be optimal candidates for an earlier initiation of adjuvant therapy. Given the well-known short-term physiological impact of gastrectomy, there is a concrete risk that patients starting chemotherapy very early after surgery may actually receive a suboptimal treatment—most notably through dose reductions—precisely in the first cycles, when dose intensity may be most critical. Finally, the heterogeneity of the adjuvant chemotherapy regimens, which persists even after propensity score matching, further complicates interpretation of the results and limits the ability to draw firm conclusions regarding the true effect of treatment timing per se. "
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Lin L, Zhang P, Wang YY, Cai YF, Wen LB, Chen WP, Xiao YF, Li ZK, Liu GY. Early vs conventional initiation of adjuvant chemotherapy in advanced gastric cancer: A propensity-matched outcomes study. World J Gastroenterol 2025; 31(42): 110069
2
"Long-term prognosis of HBV-cirrhosis hepatocellular carcinoma recurrence and mortality rates post-treatment with antivirals TDF, TAF, ..."
[Read more]
"Long-term prognosis of HBV-cirrhosis hepatocellular carcinoma recurrence and mortality rates post-treatment with antivirals TDF, TAF, ETV and curative radiofrequency ablation is still controversial Dina Johar* Department of Biochemistry and Nutrition, Faculty of Women for Arts, Sciences and Education, Ain Shams University, Heliopolis, Cairo, Egypt *Dina Johar, PhD Department of Biochemistry and Nutrition Faculty of Women for Arts, Sciences, and Education Ain Shams University, Cairo, Egypt Phone:+2 01060782045 Email: dinajohar@gu.edu.eg • To whom correspondence should be addressed Abstract The efficiency of antiviral agents for hepatitis B cirrhosis-related hepatocellular carcinoma (HCC) is still an important clinical challenge with high recurrence rates. In this commentary, we focus on recent findings from Xu et al. We highlight the potential benefit of studying HBV genotypes and subgenotypes as possible mechanisms behind different responses to antivirals. Mechanisms of viral reactivation that parallel HCC recurrence remain uncovered. The commentary is a significant step forward in understanding the nuanced approach to managing HCC recurrence and mortality rate in HBV-cirrhosis patients, offering valuable insights for clinical decision-making. Keywords HBV-related HCC, TDF, TAF, ETV, recurrence, mortality Core Tip A similar virological response to TDF, TAF, and ETV treatment in the first 6-12 months may require further investigation to understand early treatment dynamics. Understanding how HBV genotypes and subgenotypes influence chronic active HBV infection is crucial. Investigating potential molecular mechanisms that explain recurrence rate differences helps develop predictive models for individualized treatment selection. Background The paper entitled “Effect of antiviral therapy on 3-year recurrence and prognosis of hepatocellular carcinoma after curative radiofrequency ablation” by Xu et al. (1) is a robust retrospective cohort study that comprehensively evaluates long-term prognostic effects of advanced nucleos(t)ide analogs (NAs): ETV, TDF, and TAF on HBV-cirrhosis HCC patients post-RFA outcomes. The study identified four independent predictors of post-RFA HCC recurrence. The study findings recommend TDF or TAF as preferred antiviral agents for the long-term management of such patients. The three antiviral agents had a similar impact on the three-year mortality rate. The study used a substantial sample size (n=319) with a follow-up period of 144 weeks, across multiple time points (6, 12, 24, 36 months), although the sample sizes in the TDF (n=76) and TAF (n=52) groups are relatively small. Two of the major determinants of the outcome of chronic HBV infection are the HBV genotypes and subgenotypes. While Xu et al. adhered to established diagnostic guidelines, there are at least ten different confirmed HBV genotypes (A-J). There is limited knowledge about how different genotypes and subgenotypes of HBV affect the risk of HCC recurrence in patients with HBV-cirrhosis related HCC. The best way to find out is through long-term, population-based studies. These studies should compare people with different genotypes and follow them over time. For example, there is a substantial homogeneity of HBV subtypes found in Egypt, a country with a comparably high HBV-cirrhosis-related HCC, mostly genotype D, subgenotype D3, hepatitis B surface antigen (HBsAg) subtype ayw2, with a prevalence of the Major Hydrophilic Region (MHR) mutations (2). Genotype D is related to more advanced liver disease, i.e., HCC, than other genotypes (3) and is an independent risk for Fulminant Hepatitis (FH) (4). Whether new classes of drugs are needed to manage chronic HBV, whether a cure is possible, or even necessary, has not been addressed. The goal of new therapies for chronic hepatitis B should be to achieve a virological cure. Current NAs can slow down HBV replication and help improve liver damage. However, they rarely fully clear chronic HBV infections. There is an urgent need for new drugs and more effective strategies to combat the virus, which eventually will help get rid of the cancer. Still, more research is needed to find clear links between specific genotypes and risks like cirrhosis or HCC. Some research has been carried out in areas such as Asia and Alaska, but many genotypes, including A1 and D, have not been studied in long-term, prospective research. Data is missing for some genotypes and subgenotypes, such as A3, E, F4, and H, regarding their impact on health. Collaboration between multiple institutions from different countries enhances the strength of these studies. Retrospective and prospective studies examined serum HBV DNA levels, liver function, complication rates, and hospital stay duration (5, 6). A study looked at whether high-dose TDF therapy can stop HBV-related HCC recurrence. They designed a study where everyone received the same treatment, with no comparison group. The goal was to determine if using high-dose TDF is practical in real-world settings. They enrolled 10 patients in September 2015 and monitored their progress for three months or until they had to discontinue treatment early. They found that high doses of TDF, up to five times the recommended amount, are poorly tolerated by many patients. These doses also do not effectively stop HBV from replicating as HCC progresses (7). In 2018, a study looked at 607 patients with HBV-related HCC who had surgery or RFA. They divided them into three groups based on their antiviral drugs. The first group, with 261 patients, did not get antiviral treatment. The second group, with 90 patients, received low-strength NAs. The last group, with 256 patients, was treated with high-strength NAs. The main goal was to see how long patients stayed free of cancer recurrence. Patients on ETV and TDF had fewer recurrences than those on other antivirals (8). Another study followed 1,695 patients who had surgery for HBV-related HCC at Korea’s Barcelona Clinic Liver Cancer stage 0 or A between 2010 and 2018. Of these, 813 patients received ETV while 882 took TDF. The study compared cancer recurrence and overall survival between the two groups, using statistical methods to match patients’ backgrounds and adjust for other confounding factors. The analysis started from the day of their liver surgery. Results showed that patients on TDF had a notably lower chance of their HCC recurrence and survived longer overall than those on ETV (9). Between 2013 and 2017, three hospitals enrolled patients with HBV-related HCC who had surgery or ablation as their first treatment. A 421 patients had part of their liver removed, and 305 received RFA. All of these patients started antiviral medication using either ETV or TDF. The study examined HCC recurrence and mortality rates. Researchers adjusted for factors such as HBV DNA levels, tumour characteristics, and patient demographics. The results showed no significant difference in cancer recurrence or death rates between patients treated with ETV and TDF (10). Patients with HCC who go beyond the Milan criteria tend to have a high chance of HCC recurrence post-surgery. When comparing treatments, TDF significantly reduces the risk of HCC recurrence more than ETV therapy (11). Using propensity score matching from the date of liver resection for HCC, TDF showed better overall survival. It also offered stronger protection of liver function. However, in another study, there was no difference in the rate of HCC recurrence between TDF and ETV treatments (12). Other research shows that TDF works better than ETV for eliminating hepatitis B symptoms after RFA treatment. It helps reduce serum HBV DNA levels and improves the albumin-bilirubin (ALBI) grade more effectively (13) (14). A study in 2024 looked at how TDF and ETV affect long-term health in patients with HCC, fatty liver disease, and HBV. The researchers analyzed patient data using a multivariate Cox proportional hazards model and applied a propensity score matching method. They then compared survival outcomes with Kaplan-Meier survival curves. The results showed that TDF helped improve long-term prognosis for patients (15). The latter discovery was confirmed in 2025 in patients with high HBsAg levels after they had their liver removed (16). A study looked back over ten years, finishing in 2025. It included 1,396 patients with HBV-related cirrhotic HCC who had surgery. The patients were divided into two groups: those who took antiviral medicine and those who did not. The research focused on HCC recurrence, taking into account when the antiviral treatment was started, how well the virus was kept under control, and the levels of HBV DNA. Recurrences were labelled as early if they occurred within two years and late if they occurred after that. The study found that long-term antiviral therapy helped prevent late recurrence after surgery, regardless of whether it was started pre- or post-operation. Patients who responded well to the virus treatment saw the biggest benefit (17). Given such controversial results, in Xu et al. study, being a single-center study, there is potential for selection bias inherent in the retrospective study design. The uneven baseline characteristics across treatment groups, potential need for larger sample size to validate findings, and limited exploration of potential mechanisms are behind the differential recurrence rates achieved with TDF, TAF versus ETV, or even behind the similar impact that the three NAs had on the three-year mortality rate. The study will benefit from extending the follow-up period to provide more comprehensive long-term insights. Considering propensity score matching to reduce potential selection bias. Expanding the research scope through multi-center collaborative study enhances external validity and generalizability. Exploring potential interaction effects between NAs and the molecular mechanisms underlying the differential efficacy of TDF and TAF is insightful. Including more diverse patient populations enhances analytical approach, provides a nuanced understanding of anti-HBV agent effectiveness and contributes to a personalized medicine approach in hepatology. Including sensitivity analyses helps validate findings. Declarations Funding This commentary did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. The author declare that no honorarium, grant, or other form of payment was given to anyone to produce the manuscript. Conflict of interest The author declares no conflict of interest exists. Consent to publish Not applicable. Availability of data and materials All data generated or analyzed during this study are included in this published article. Acknowledgment N/A References 1. Xu B, Zhang X, Liu F, Li F, Zhang X, Xiang H, et al. Effect of antiviral therapy on 3-year recurrence and prognosis of hepatocellular carcinoma after curative radiofrequency ablation. World J Gastrointest Oncol 2025;17: 112689. 2. Abu Zeid WA RD, Shemis MA,. Prevalence of mutations within major hydrophilic region of hepatitis B virus and their correlation with genotypes among chronically infected patients in Egypt. Arab Journal of Gastroenterology 2016 17 (2016) 34–40. 3. Thakur V, Guptan RC, Kazim SN, Malhotra V, SK. S. Profile, spectrum and significance of HBV genotypes in chronic liver disease patients in the Indian subcontinent. . J Gastroenterol Hepatol. 2002;17:165-70. 4. Wai CT, Fontana RJ, Polson J, Hussain M, Shakil AO, Han SH, et al. US Acute Liver Failure Study Group. Clinical outcome and virological characteristics of hepatitis B-related acute liver failure in the United States. J Viral Hepat. 2005 12:192-8. 5. Yuan B, Li R, Yuan W, Xiang B, Zheng M, Yang T, et al. Perioperative entecavir for patients with HBV-related hepatocellular carcinoma and low levels of viral DNA: analysis using propensity score matching. Oncotarget. 2017 16(31):51810-6. 6. Yoo S, Jang J, Kwon J, Jung S, Jang B, Choi J. Preemptive antiviral therapy with entecavir can reduce acute deterioration of hepatic function following transarterial chemoembolization. . Clin Mol Hepatol. 2016 22:458-65. 7. Hwang S, Song G, Jung D, Yoon Y, Yoo H, Tak E. High-dose tenofovir is not effective in suppressing hepatitis B virus replication in patients with hepatocellular carcinoma progression: a preliminary result. Korean J Hepatobiliary Pancreat Surg.2016(1). 8. Cho H, Ahn H, Lee DH, Lee JH, Jung YJ, Chang Y, et al. Entecavir and tenofovir reduce hepatitis B virus-related hepatocellular carcinoma recurrence more effectively than other antivirals. . Journal of viral hepatitis. 2018;25:707–17. 9. Choi J, Jo C, Lim YS. Tenofovir Versus Entecavir on Recurrence of Hepatitis B Virus-Related Hepatocellular Carcinoma After Surgical Resection. Hepatology (Baltimore, Md). 2021 73(661–673). 10. Lee JH, Kim BK, Park SY, Tak WY, Park JY, Kim DY, et al. The efficacies of entecavir and tenofovir in terms of enhancing prognosis after curative treatment of hepatitis B virus-related hepatocellular carcinoma. . Eur J Intern Med.2021:48-55. 11. Shen J, Qi W, Dai J, Leng S, Jiang K, Zhang Y, et al. Tenofovir vs. entecavir on recurrence of hepatitis B virus-related hepatocellular carcinoma beyond Milan criteria after hepatectomy. . Chinese medical journal. 2021;135:301–8. 12. Wang XH, Hu ZL, Fu YZ, Hou JY, Li WX, Zhang YJ, et al. Tenofovir vs. entecavir on prognosis of hepatitis B virus-related hepatocellular carcinoma after curative resection. . Journal of gastroenterology. 2022;57:185–98. 13. Hu Z, Zeng H, Hou J, Wang J, Xu L, Zhang Y, et al. Tenofovir vs. Entecavir on Outcomes of Hepatitis B Virus-Related Hepatocellular Carcinoma after Radiofrequency Ablation. Viruses. 2022;14(656). 14. Giri S, Agrawal D, Afzalpurkar S, Gopan A, Angadi S, Sundaram S. Tenofovir versus entecavir for tertiary prevention of hepatocellular carcinoma in chronic hepatitis B infection after curative therapy: A systematic review and meta-analysis. . Journal of viral hepatitis. 2023;30:108–15. 15. Kong Q GQ, Li W, Chen Z. Effect of tenofovir versus entecavir on the long-term prognosis in hepatocellular carcinoma patients with concurrent metabolic dysfunction-associated steatotic liver disease and hepatitis B. Asian J Surg. 2024 Nov;47(11):4725-4734. doi: 10.1016/j.asjsur.2024.03.147. Epub 2024 Sep 16. PMID: 39289060. 16. Qiu Z XY, Qi W, Shen J, Wen T, Li C. Tenofovir vs Entecavir on the Prognosis of Patients With Hepatitis B Virus-Related Hepatocellular Carcinoma After Liver Resection: The Role of HBsAg Levels. Clin Transl Gastroenterol. 2025 Mar 1;16(3):e00814. doi: 10.14309/ctg.0000000000000814. PMID: 39791573; PMCID: PMC11932590. 17. Liu J BS, Shi X, Yuan T, Yu Y, Lin J, Dai C, Wu Y, Cui L, Zhu B, Fu X, Wang K, Yu W, Li J. Benefits of entecavir therapy in HBV-related hepatocellular carcinoma patients with compensated cirrhosis after hepatectomy: A ten-year retrospective cohort study. Eur J Surg Oncol. 2025 May;51(5):109621. doi: 10.1016/j.ejso.2025.109621. Epub 2025 Jan 23. PMID: 39919509. "
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Xu BG, Zhang X, Liu F, Li FH, Zhang X, Xiang HL, Liang J. Effect of antiviral therapy on 3-year recurrence and prognosis of hepatocellular carcinoma after curative radiofrequency ablation. World J Gastrointest Oncol 2025; 17(11): 112689
3
"This study has provided a combined method including ultrasound and endoscopic examination to present the clinical features of ..."
[Read more]
"This study has provided a combined method including ultrasound and endoscopic examination to present the clinical features of pancreatic cancer in patients with old age. The lifestyles of these patients can be analyzed to perform the potential relationship in the prognosis of pancreatic cancer. In addition, the important features in malignant level as this study displayed may be summarized by author's efforts to indicate significantly and meaningfully in the prognosis of pancreatic cancer in patients. "
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Zignani N, Balzarini M, Dabizzi E, Fracas E, Millefanti L, Segato S, Vecchi M, Cengia G, Missale G, Tontini GE, Moneghini D, Cavallaro F. Endoscopic ultrasound features of pancreatic solid lesions: Descriptive and predictive analysis on a multicenter sample. World J Gastrointest Endosc 2025; 17(11): 112487
4
"The comprehensive review by Professor Elsayed offers a timely and insightful overview of a critical clinical challenge: the management ..."
[Read more]
"The comprehensive review by Professor Elsayed offers a timely and insightful overview of a critical clinical challenge: the management of recurrent hepatocellular carcinoma (RHCC). As a clinician actively managing HCC patients, I find this synthesis of evidence exceptionally valuable. RHCC indeed lacks standardized guidance, and this review effectively consolidates fragmented data across surgical, locoregional, and systemic modalities, offering pragmatic approaches tailored to recurrence patterns (intrahepatic vs. extrahepatic), liver functional reserve, and prior interventions. RHCC complexity demands collaboration between hepatologists, surgeons, interventional radiologists, and oncologists—highlighted here as essential for optimizing outcomes. The candid discussion on limitations—such as the reduced functional liver remnant post-resection/transplant, donor shortages for salvage LT (SLT), and the aggressive biology of RHCC—grounds the review in clinical reality. Coverage of emerging strategies—like combination therapies (TACE + sorafenib), novel ICIs (e.g., atezolizumab/bevacizumab), and AI-driven recurrence prediction—provides hope and direction for ongoing research. While ther are some points for further discussion. In practice, SLT candidates often face adverse factors (e.g., time to recurrence "
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Elsayed MOK. Treatment of recurrent hepatocellular carcinoma: The current standards and future perspectives. World J Gastrointest Oncol 2025; 17(11): 110735
5
"The study provides strong evidence that circulating GDF15 levels are elevated in IBD patients, with a clear correlation to markers ..."
[Read more]
"The study provides strong evidence that circulating GDF15 levels are elevated in IBD patients, with a clear correlation to markers of inflammation and intestinal permeability. This relationship could offer a new avenue for monitoring disease progression and assessing the severity of IBD. The results showing that GDF15 impacts the intestinal barrier function by modulating tight junctions such as ZO-1 and claudin 1 are especially intriguing. From a clinical standpoint, understanding how GDF15 contributes to barrier dysfunction could lead to new therapeutic targets aimed at preventing the "leaky gut" phenomenon, which is a key feature in IBD. One of the most interesting aspects is the suggestion that GDF15 could be a potential biomarker for intestinal permeability, which could be valuable in both clinical diagnosis and disease monitoring. However, as a clinician, I’d like to see more clarity on how these findings might translate into practical treatment strategies. For instance, how could we use this information to develop therapies targeting GDF15 or its signaling pathways in patients with IBD? Additionally, while the in vitro findings are compelling, clinical trials will be essential to confirm whether modulating GDF15 can indeed improve clinical outcomes for IBD patients. "
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Ruiz-Malagón AJ, Herraiz-Vilela M, Serrano-Pino R, García-Ávila P, Díaz- Suárez L, Carmona-Segovia AD, Becerra-Munoz VM, Jiménez-Navarro M, Arranz-Salas I, López-Villodres JA, Fernández-Castañer A, Gutiérrez-Martínez F, Rodríguez-González FJ, Camargo-Camero R, Alcaín-Martínez G, Rodríguez-Díaz C, García-Fuentes E, Sánchez-Quintero MJ, López-Gómez C. Growth differentiation factor 15 alters intestinal barrier and increases permeability: A new molecular target in inflammatory bowel disease. World J Gastroenterol 2025; 31(41): 110955
6
"As a clinician, I found this study highly relevant and practical. The use of VCTE to assess liver fibrosis in PBC patients offers ..."
[Read more]
"As a clinician, I found this study highly relevant and practical. The use of VCTE to assess liver fibrosis in PBC patients offers a non-invasive, reliable alternative to liver biopsies, which is a huge advantage in daily practice. The dual cut-off approach for diagnosing advanced fibrosis seems useful, providing clear thresholds that can guide treatment decisions without the need for invasive procedures. However, the grey area (10-14.5 kPa) remains a challenge, and it would be helpful to have additional tools or markers for better decision-making in these cases. Overall, this study offers a valuable, non-invasive method for fibrosis assessment, but more research on managing patients in the grey zone would be beneficial. "
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Chen JL, Hou YX, Liu Y, Jiang YY, Wang XB. Real-world performance of transient elastography in assessing advanced fibrosis in Chinese patients with primary biliary cholangitis. World J Gastroenterol 2025; 31(41): 111256
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"Transient Elastography is an easy, bedside, non-invasive test for assessing liver fibrosis. PBC is a condition for which earlier ..."
[Read more]
"Transient Elastography is an easy, bedside, non-invasive test for assessing liver fibrosis. PBC is a condition for which earlier diagnosis and treatment are associated with a better prognosis. So, evaluating Fibrosis has important diagnostic and therapeutic implications in PBC. However, studies on TE in PBC are limited to Asian settings, and the study by Jia-Liang Chen provides important data in this subset. In this retrospective study, they compared TE with the gold-standard findings of liver biopsy. They showed that TE is highly accurate for diagnosing Advanced fibrosis, and LSM has outperformed other fibrotic markers in ROC curves. Furthermore, they have classified patients with LSM into early, indeterminate, and late stages based on the LSM cut-off; these stages may have future prognostic significance. Future Prospective observational studies can be conducted to assess changes in LSM with treatment, disease progression, or complications. "
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Chen JL, Hou YX, Liu Y, Jiang YY, Wang XB. Real-world performance of transient elastography in assessing advanced fibrosis in Chinese patients with primary biliary cholangitis. World J Gastroenterol 2025; 31(41): 111256
8
"The authors presented a case of pancreatic tuberculosis and provided a detailed analysis of the diagnostic process, which holds ..."
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"The authors presented a case of pancreatic tuberculosis and provided a detailed analysis of the diagnostic process, which holds significant reference value for the diagnosis of similar cases. However, the report lacks an in-depth discussion and evaluation of the treatment approach and therapeutic strategy employed in this case, thereby limiting its applicability in guiding clinical management of analogous conditions. Consequently, the inclusion of a comprehensive treatment plan would substantially enhance the clinical utility and overall contribution of this case report. "
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Nima CL, Wang HG, Zhou Q. Pancreatic tuberculosis: A case report and review of literature. World J Gastroenterol 2025; 31(41): 110398
9
"This study has compared several computational methods to be used in the predication of prognosis for acute variceal bleeding in ..."
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"This study has compared several computational methods to be used in the predication of prognosis for acute variceal bleeding in cirrhosis patients. Author claimed that the convolution network by their efforts displayed the best effect in the outcomes analysis rather than another methods. However, the specific features in different subgroups with data presentations using AI or other computational methods lacked in the full analysis to be performed in the compared computation process. This means that this study only provides the end result for supporting their analysis as they wanted. In addition, the standard between high and low risk group presented to differ significantly without clinical parameters in this study. "
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Xiang Y, Yang N, Zheng TL, Huang YF, Liu TY, Ma DQ, Hu SJ, Zhang WH, Xiang HL, Zhang LY, Yuan LL, Wang X, Dang T, Zhang G, Wu B, Peng LJ, Gao M, Xia DL, Liu ZB, Li J, Song Y, Zhou XQ, Qi XS, Zeng J, Tan XY, Deng MM, Fang HM, Qi SL, He S, He YF, Ye B, Wu W, Shao JB, Wei W, Hu JP, Yong X, He CH, Bao JL, Zhang YN, Ji R, Bo Y, Yan W, Li HJ, Li SL, Geng S, Zhao L, Liu B, Qi XL. Development of a deep learning model for guiding treatment decisions of acute variceal bleeding in patients with cirrhosis. World J Gastroenterol 2025; 31(41): 111361
10
"This article is a well-conducted clinical study that elucidates the psychological profiles of patients undergoing esophagectomy for ..."
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"This article is a well-conducted clinical study that elucidates the psychological profiles of patients undergoing esophagectomy for esophageal cancer. Its core contributions lie in: 1. Demonstrating a significant negative correlation among anxiety, depression, and mindfulness, advancing understanding of the mind–body interaction in surgical oncology; 2. Identifying key demographic and clinical risk factors that shape postoperative emotional outcomes, thereby guiding individualized psychological assessment and intervention. By linking psychometric evaluation with perioperative management, this study offers a valuable reference for integrating mindfulness-based strategies into holistic recovery pathways. "
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Deng X, Hu YH, Xiong YJ, Mao N, Hong B, He G. Correlation of anxiety and depression with mindfulness in esophageal cancer patients undergoing esophagectomy and analysis of risk factors. World J Psychiatry 2025; 15(9): 104813
11
"The article is well-written and demonstrates a clear and logical flow from the introduction to the conclusion. The research objectives ..."
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"The article is well-written and demonstrates a clear and logical flow from the introduction to the conclusion. The research objectives are clearly stated, and the study design appropriately addresses the research questions. The literature review is comprehensive and up to date, providing a strong theoretical foundation for the study. The methodology is well-described, enabling replication, and the data analysis is appropriate and rigorous. The discussion effectively interprets the findings in relation to existing studies, and the conclusions are supported by the results. Overall, this is a good-quality manuscript that makes a valuable contribution to the field. "
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Yanti L, Surtiningsih, Ardiyani FHN, Sekarini NNAD, Susanti D, Mustaan, Murniati, Supriyadi, Santosa A. Long-term consequences of unintended pregnancy: Impacts on early childhood growth and development in a multicenter study. World J Clin Pediatr 2025; 14(4): 107346
12
"The retrospective study by Huang and colleagues provides valuable insights into the prevalence and clinicopathological significance ..."
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"The retrospective study by Huang and colleagues provides valuable insights into the prevalence and clinicopathological significance of HER2 expression in upper tract urothelial carcinoma. Their finding that HER2 overexpression is strongly associated with high tumor grade but not with conventional markers of disease progression underscores the distinct biological behavior of UTUC compared to bladder cancer. This work is particularly relevant as it highlights a potential therapeutic target in a disease with limited treatment options. However, the clinical implications of HER2 expression in UTUC must now be reinterpreted in light of the practice changing results presented at the ESMO Congress 2025. The phase 3 RC48 C016 trial demonstrated for the first time that a combination of the anti HER2 antibody drug conjugate disitamab vedotin and the anti PD1 immunotherapy toripalimab significantly outperforms standard platinum based chemotherapy in the first line treatment of HER2 expressing locally advanced or metastatic urothelial carcinoma. The results are striking: Progression free survival was nearly doubled (13.1 months versus 6.5 months; HR = 0.36); Overall survival showed a remarkable improvement (31.5 months versus 16.9 months; HR = 0.54); Benefits were consistent across all HER2 expression levels (IHC 1+, 2+, and 3+); and The combination also exhibited a more favorable safety profile. These findings represent a paradigm shift. For the first time, a biomarker directed strategy has proven superior to chemotherapy in the first line setting for advanced UC. Given that HER2 expression is found in up to 70% of urothelial carcinomas, this new regimen could benefit a majority of patients. In this context, the work by Huang et al gains even greater importance. Their observation that nearly half of UTUC tumors (46.2%) show HER2 positivity especially in high grade disease suggests that a substantial proportion of UTUC patients may be candidates for this novel, highly effective combination therapy. The authors call for clinical trials evaluating HER2 targeted therapies in high grade, HER2 positive UTUC is now more urgent than ever. Future studies should urgently validate the efficacy of disitamab vedotin plus toripalimab in UTUC specific cohorts and explore its potential in earlier disease stages. The era of biomarker driven therapy for urothelial carcinoma has arrived, and HER2 is firmly at its center. Reference: Sheng X, He Z, Zhang G, et al. Primary results from the phase 3 RC48 C016 trial: Disitamab vedotin plus toripalimab versus chemotherapy as first line treatment for HER2 expressing locally advanced or metastatic urothelial carcinoma. Annals of Oncology 2025;36(Supplement 3):S1573 S1574. "
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Huang L, He J. Human epidermal growth factor receptor 2 overexpression is associated with high-grade tumors in upper tract urothelial carcinoma. World J Clin Oncol 2025; 16(10): 110047
13
"This review on the gut-liver axis provides a highly insightful and comprehensive exploration of the evolving role of the microbiome ..."
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"This review on the gut-liver axis provides a highly insightful and comprehensive exploration of the evolving role of the microbiome in liver diseases. It successfully ties together mechanisms of microbiome dysbiosis with the pathogenesis of various hepatic conditions, including metabolic dysfunction-associated liver disease, cirrhosis, and cholangiopathies. The authors delve into how imbalances in gut microbiota disrupt bile acid metabolism, increase intestinal permeability, and promote inflammation, which in turn drives liver injury. The article's coverage of emerging treatment options, including bacteriophage therapy and genetic engineering of gut microbes, is particularly noteworthy, reflecting a growing understanding of the microbiome's potential as a therapeutic target. This forward-thinking approach adds substantial clinical relevance, making the article valuable for researchers and clinicians looking to integrate microbiome-based therapies into practice. "
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Anis MA, Shahid Y, Majeed AA, Abid S. Microbiome and gut-liver interactions: From mechanisms to therapies. World J Gastroenterol 2025; 31(40): 111409
14
"This study offers a compelling and innovative exploration of colonoscopy quality, addressing the critical interplay between insertion ..."
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"This study offers a compelling and innovative exploration of colonoscopy quality, addressing the critical interplay between insertion time and withdrawal duration to optimize adenoma detection rate (ADR). The proposed "insertion-to-withdrawal" paradigm marks a significant departure from fixed withdrawal time standards, advocating for a personalized approach—a novel and practical advancement. The development of a Shiny app to deliver real-time, individualized guidance further enhances its clinical relevance, providing endoscopists with a valuable tool to improve outcomes. Several aspects warrant deeper consideration. First, the hybrid SVM-XGBoost model's modest discriminative performance (AUC ≈ 0.64) suggests limitations in its current predictive power, likely due to unaddressed variables such as bowel preparation nuances, insertion difficulty, or segment-specific inspection times. Expanding the dataset with multicenter inputs and incorporating these factors could refine its accuracy. Second, while insertion time serves as a proxy for procedural complexity, its validation against objective difficulty scales or video analysis would bolster the mechanistic basis of the findings. Third, the personalized strategy’s generalizability remains untested; prospective multicenter validation across diverse demographics, endoscopist expertise, and regions is essential. Finally, evaluating real-world app adoption and its impact on ADR adherence would provide critical evidence of its efficacy. Overall, this study lays a robust foundation for data-driven personalization in endoscopy, moving beyond uniform metrics. With further refinement and validation, it has the potential to transform clinical practice significantly. "
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Xu BX, Xu CZ, Zhang HY, Chen XJ, Wei BN, Yang C. Personalizing withdrawal time by insertion time to achieve target adenoma detection rate in colonoscopy. World J Gastroenterol 2025; 31(38): 111364
15
"I want to congratulate Yang-Yang Xiong for publishing an excellent study comparing Endoscopic Clip or EUS Coil-assisted glue for ..."
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"I want to congratulate Yang-Yang Xiong for publishing an excellent study comparing Endoscopic Clip or EUS Coil-assisted glue for gastric varices. The authors have shown that EUS-guided therapy is more costly and involves high operating time; however, it has similar technical eradication of gastric varices and re-bleeding rates even in larger varices > 4 cm. The size comparison may not be uniform, as the Endoscopic group measured by endoscopic appearance, which may be as accurate as EUS measurement. The Authors have shown only a 5-day rebleeding rate; adding delayed rates could have been more impactful. There is a discrepancy in the table and image regarding post-injection ulcer; the Image shows a post-glue ulcer in both groups, whereas in the table, it was zero; these typographical errors could have been avoided. The eradication time frame is not mentioned; whether it is immediately or 5 days, as the rebleeding rate or any other time frame is not clear. The Follow up endoscopy data is not given; if done even after CT showing eradication of varices or for other GI Bleeding, the time at which it was done was not mentioned, and the procedure done when eradication is not established is also not given. Despite these limitations the study has provided a meaning ful comparison and can change my practice "
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Xiong YY, Li DW, Zhou TY, Ma H, Gao JG, Shen Z, Xu CF, Yu CH. Clip-assisted endoscopic cyanoacrylate injection vs endoscopic ultrasound-guided coil and cyanoacrylate injection for gastric varices: A propensity score-matched study. World J Gastroenterol 2025; 31(38): 111363
16
"This article provides a timely and valuable overview of emerging therapeutic strategies for managing IBD. The integration of physical ..."
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"This article provides a timely and valuable overview of emerging therapeutic strategies for managing IBD. The integration of physical exercise and VNS as adjuncts to traditional pharmacological treatments is particularly relevant, as clinicians are increasingly seeking non-invasive and complementary approaches to help manage chronic inflammatory diseases. The article does an excellent job of explaining how these interventions may improve autonomic regulation, reduce inflammation, and promote gut health, which are all essential factors in managing the symptoms and progression of IBD. The focus on the vagus nerve’s role in regulating the immune system through the cholinergic anti-inflammatory pathway presents an interesting potential for VNS as a therapeutic tool. The idea that VNS could restore normal immune function, protect the intestinal barrier, and improve the composition of the gut microbiota is compelling, especially for patients who do not respond adequately to conventional treatments. This could open new avenues for clinical practice, offering patients a holistic approach to managing IBD. However, one of the challenges noted in the article is the variability in response to these non-pharmacological interventions. The review highlights how factors such as exercise intensity, duration, and individual patient factors can influence outcomes. This reflects a common issue in clinical practice, where personalized approaches are often required to determine the best intervention for a given patient. While the evidence for the benefits of physical exercise and VNS in IBD is promising, further studies are needed to establish standardized protocols and validate these therapies in diverse patient populations. The inclusion of vagotomy as a counterpoint to VNS and exercise also brings an important clinical consideration into focus. The article explains how vagotomy, by disrupting the vagal pathway, may exacerbate intestinal inflammation and worsen IBD symptoms. This serves as a reminder of the delicate balance between parasympathetic and sympathetic nervous system function and the potential risks of interfering with this balance in patients with chronic inflammatory conditions. "
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da Silva ACA, Severo JS, dos Santos BLB, Soares HS, Martins JA, Lima RSP, Gadelha KKL, Torres-Leal FL, Correia-de-Sá P, Magalhães PJC, Santos AA, da Silva MTB. Role of physical exercise, vagal nerve stimulation, and vagotomy in inflammatory bowel disease. World J Gastroenterol 2025; 31(38): 111252
17
"This article offers a thorough and insightful overview of the transformative potential of multimodal AI in gastroenterology and ..."
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"This article offers a thorough and insightful overview of the transformative potential of multimodal AI in gastroenterology and hepatology. The application of AI across various clinical areas—from early diagnosis to precision treatment—holds great promise. However, the limitations in current AI models—such as lack of data standardization, poor model interpretability, and the need for large-scale, multi-center trials to validate findings—are all issues that would resonate with healthcare professionals. It is crucial for the clinical community to address these issues to ensure that AI technologies can be seamlessly integrated into practice without compromising patient safety or clinical outcomes. "
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Wu YM, Tang FY, Qi ZX. Multimodal artificial intelligence technology in the precision diagnosis and treatment of gastroenterology and hepatology: Innovative applications and challenges. World J Gastroenterol 2025; 31(38): 109802
18
"Gestational diabetes (GD) is a complex disorder with metabolic, inflammatory, genetic, and fetoplacental unit display. The screening ..."
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"Gestational diabetes (GD) is a complex disorder with metabolic, inflammatory, genetic, and fetoplacental unit display. The screening is based on oral glucose tolerance tests (OGTT) (one-step and two-step), OGTT is limited by low sensetivity. I addition, it is combersome test and the recommendations and cut-off varied significantly between International Organization. GD is common and is associated with poor maternal and fetal outcomes and the development of type 2 diabetes. The intergration of metabolic, inflammatory, genetic, urinary, and placental biomarkers is highly relevant for the personalized approach among various women. The article is of great interset worldwide, I am very thrilled to write and editorial on this interesting manuscript. Hyder Mirghani, Professor of Internal Medicine and Endocrine, University of Tabuk, Saudi Arabia "
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Kaymak D, Ozgu-Erdinc AS. Advances in gestational diabetes mellitus screening: Emerging trends and future directions. World J Diabetes 2025; 16(10): 111309
19
"Hu et al. (World J Gastroenterol. 2025;31:109528) presented a multicenter study evaluating image-guided thermal ablation (IGTA) for ..."
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"Hu et al. (World J Gastroenterol. 2025;31:109528) presented a multicenter study evaluating image-guided thermal ablation (IGTA) for oligometastatic colorectal cancer (CRC) with lung involvement. Among 336 patients treated between 2014 and 2022, the 3- and 5-year overall survival rates were 59.5% and 41.0%, respectively, demonstrating meaningful long-term benefit. Extrapulmonary metastases, particularly in the bone and abdominal cavity, significantly worsened outcomes, whereas patients with liver-only metastases had comparatively favorable survival. Elevated tumor markers (CEA, CA19-9), greater tumor burden, and absence of systemic therapy were adverse prognostic factors. Notably, combining IGTA with systemic therapy improved overall survival. This study underscores IGTA as a viable, minimally invasive treatment for patients with oligometastatic CRC and highlights the prognostic relevance of metastatic distribution in guiding personalized therapy. "
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Hu XF, Dong XJ, Gu XY, Hu JH, Li XH, Zhao FH, Xia XW, Fan HJ, Xu SF. Extrapulmonary metastases impact survival outcomes of thermal ablation for colorectal lung oligometastases: A multicenter study. World J Gastroenterol 2025; 31(38): 109528
20
"Hyperuricemia and high density lipoproteins are imprortant metabolic and inflammatory biomarkers, they are easy to obtain. In ..."
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"Hyperuricemia and high density lipoproteins are imprortant metabolic and inflammatory biomarkers, they are easy to obtain. In addition, they are among the cardiovascular risk factors (among other ) and are component of the metabolic syndrome. Depression and tpe 2 diabetes are common health disorders with significant burden on the patients, healthcare system, and the community. When the above diseases present together they exacerbate each other serious consequences. Assessing the uric acid-to-high-density lipoprotein cholesterol ratio in diabetes and psychological disease is highly relevant because they are attainable and the literature on these important parameters is scarce. Thank you very much for the invitation and I would like to publish a letter to the Editor on this interesting topic. "
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Xu H, He DJ, Luo C, Yu XM, Duan CZ, Sun D, Wu DJ, Mao XQ, Jiang WF. Association between uric acid to high-density lipoprotein ratio and mental health symptoms in people with type 2 diabetes. World J Diabetes 2025; 16(10): 110211
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