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2025-11-06 | Browse: 10 | Download: 0
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800 items Read more >>
1
"I am highly satisfied with the editorial team for the smooth and successful publishing of this article. I am also highly thankful ..."
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"I am highly satisfied with the editorial team for the smooth and successful publishing of this article. I am also highly thankful to the Editor in chief for the initial evaluation of this manuscript and the peer reviewers for their critical evaluation of this article. Lastly, my sincere thanks are also to the Dr. Ma and publishing director for inviting me to submit this article. "
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Khan MM. Erythrocyte membrane nervonic acid in drug-naive first-episode psychosis and chronic medicated schizophrenia: Implication for impaired myelination and prognosis. World J Psychiatry 2025; 15(11): 109162
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"My publishing experience with the journal was highly satisfying. The editorial team maintained excellent communication, providing ..."
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"My publishing experience with the journal was highly satisfying. The editorial team maintained excellent communication, providing prompt responses and clear guidance throughout the process. The peer review was constructive and professional, ensuring quality improvement. Overall, the journal demonstrated efficiency, transparency, and exceptional support, making the entire experience smooth and rewarding. "
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Muniandy S, Yahya HM, Shahar S, Kamisan Atan I, Mahdy ZA, Rajab NF, Mohd Rasdi HF, George A, Chinnappan SM. Effect of Eurycoma longifolia water extract (Physta®) on menopausal quality of life and mood states. World J Clin Cases 2025; 13(31): 109113
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"I am highly satisfied with my experience publishing in the World Journal of Gastroenterology. This journal provided me with substantial ..."
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"I am highly satisfied with my experience publishing in the World Journal of Gastroenterology. This journal provided me with substantial assistance and support throughout the publication process.The editorial team was professional and efficient,and their constructive feedback helped me further refine my article.Communication was timely and clear,allowing me to navigate each step smoothly.Additionally,the journal offered a wealth of resources and guidance that greatly benefited me during the writing and revision process.I am truly grateful for the professional service and careful guidance provided by the journal during the publication process,which was a valuable and enjoyable experience for me. "
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Han JF, Jia ZY, Fan X, Zhao XY, Cheng LY, Xia YX, Ji XR, Zang WQ. Mechanisms of ferroptosis in primary hepatocellular carcinoma and progress of artificial intelligence-based predictive modeling in hepatocellular carcinoma. World J Gastroenterol 2025; 31(41): 111174
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"It has been a great pleasure collaborating with the World Journal of Psychiatry. The editorial process was highly transparent, ..."
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"It has been a great pleasure collaborating with the World Journal of Psychiatry. The editorial process was highly transparent, efficient, and well organized. The reviewers’ comments were constructive and greatly improved the quality of our work. Our team had an excellent experience publishing with WJP and is sincerely grateful for the professionalism and dedication of the editorial office and reviewers. "
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Huang RC, Wareesawetsuwan N, Lin N, Li XD. Computerized cognitive behavioral therapy with sertraline in schizophrenia with depressive episodes: A 12-week randomized controlled trial. World J Psychiatry 2025; 15(11): 112431
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"I am writing to express my sincere appreciation for the excellent submission experience we had with your journal. The entire process, ..."
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"I am writing to express my sincere appreciation for the excellent submission experience we had with your journal. The entire process, from initial submission to final decision, was managed with outstanding professionalism. We found the handling editor to be exceptionally fair and communicative, ensuring transparency at every stage. The peer review feedback we received was rigorous, insightful, and truly constructive. The reviewers' suggestions were instrumental in helping us strengthen our analysis and improve the overall quality of the manuscript. We were particularly impressed by the efficiency and speed of the entire timeline. Such a rapid turnaround is rare, especially when combined with such a high-quality, thorough review. We are deeply satisfied with this fair and value-adding process and look forward to submitting future work to this journal. "
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Byeon H. Effectiveness of non-invasive interventions for internet gaming disorder: A meta-analysis of randomized controlled trials. World J Psychiatry 2025; 15(11): 110759
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"I am writing to express my sincere appreciation for the excellent submission experience we had with your journal. The entire process, ..."
[Read more]
"I am writing to express my sincere appreciation for the excellent submission experience we had with your journal. The entire process, from initial submission to final decision, was managed with outstanding professionalism. We found the handling editor to be exceptionally fair and communicative, ensuring transparency at every stage. The peer review feedback we received was rigorous, insightful, and truly constructive. The reviewers' suggestions were instrumental in helping us strengthen our analysis and improve the overall quality of the manuscript. We were particularly impressed by the efficiency and speed of the entire timeline. Such a rapid turnaround is rare, especially when combined with such a high-quality, thorough review. We are deeply satisfied with this fair and value-adding process and look forward to submitting future work to this journal. "
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Byeon H. Synthesizing the risk of postoperative delirium in organ transplantation. World J Psychiatry 2025; 15(11): 113121
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"Dear editor, I am satisfied with your submission system. I am very satisfied with this submission. The review cycle was short and ..."
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"Dear editor, I am satisfied with your submission system. I am very satisfied with this submission. The review cycle was short and the reviewers' comments were very professional.Here is one small suggestion: Please attach the templates for some of the submitted manuscripts at the upload location for easy download.Thank you. "
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Yu WH, Zong Y, Zhou JW, Xu GQ. Uncommon causes of acute small intestinal bleeding-invasive mole: A case report and review of literature. World J Gastroenterol 2025; 31(41): 112794
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"The submission system is not a smooth as in other journals. Also, the way each author has to input their affiliation is awkward ..."
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"The submission system is not a smooth as in other journals. Also, the way each author has to input their affiliation is awkward compared to other journals. But overall, it was a nice experience publishing in WJG. The peer-review process was fair and rigorous, in line with the high-impact of the journal. "
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Ruiz-Malagón AJ, Herraiz-Vilela M, Serrano-Pino R, García-Ávila P, Díaz- Suárez L, Carmona-Segovia AD, Becerra-Munoz VM, Jiménez-Navarro M, Arranz-Salas I, López-Villodres JA, Fernández-Castañer A, Gutiérrez-Martínez F, Rodríguez-González FJ, Camargo-Camero R, Alcaín-Martínez G, Rodríguez-Díaz C, García-Fuentes E, Sánchez-Quintero MJ, López-Gómez C. Growth differentiation factor 15 alters intestinal barrier and increases permeability: A new molecular target in inflammatory bowel disease. World J Gastroenterol 2025; 31(41): 110955
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"The submission process was well-organized and efficient. The author guidelines were clear and easy to follow, and the online platform ..."
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"The submission process was well-organized and efficient. The author guidelines were clear and easy to follow, and the online platform was intuitive to navigate. Communication from the editorial team was timely and supportive, which helped ensure a smooth workflow. Overall, I found the experience positive and professional, and I appreciate the system’s clarity and responsiveness throughout the submission process overall. "
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Barros AR, Monteiro S, Silva J. Ménétrier disease: A clinical review. World J Gastroenterol 2025; 31(32): 108401
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"We sincerely acknowledge the editors and reviewers of this journal for their recognition of our research work, as well as for providing ..."
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"We sincerely acknowledge the editors and reviewers of this journal for their recognition of our research work, as well as for providing numerous valuable revision comments. This study is expected to assist clinicians in enhancing their awareness of performing transient elastography in patients with Primary Biliary Cholangitis (PBC) and in improving the interpretation of liver stiffness measurements. "
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Chen JL, Hou YX, Liu Y, Jiang YY, Wang XB. Real-world performance of transient elastography in assessing advanced fibrosis in Chinese patients with primary biliary cholangitis. World J Gastroenterol 2025; 31(41): 111256
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"The submission system is extremely user-friendly, offering an intuitive and seamless experience throughout the entire process. Both ..."
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"The submission system is extremely user-friendly, offering an intuitive and seamless experience throughout the entire process. Both the editors and reviewers provided constructive and insightful feedback that significantly enhanced the scientific rigor and overall quality of my manuscript, helping me refine the study design, analysis, and presentation to a much higher academic standard. "
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Xiang Y, Yang N, Zheng TL, Huang YF, Liu TY, Ma DQ, Hu SJ, Zhang WH, Xiang HL, Zhang LY, Yuan LL, Wang X, Dang T, Zhang G, Wu B, Peng LJ, Gao M, Xia DL, Liu ZB, Li J, Song Y, Zhou XQ, Qi XS, Zeng J, Tan XY, Deng MM, Fang HM, Qi SL, He S, He YF, Ye B, Wu W, Shao JB, Wei W, Hu JP, Yong X, He CH, Bao JL, Zhang YN, Ji R, Bo Y, Yan W, Li HJ, Li SL, Geng S, Zhao L, Liu B, Qi XL. Development of a deep learning model for guiding treatment decisions of acute variceal bleeding in patients with cirrhosis. World J Gastroenterol 2025; 31(41): 111361
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"I am fully satisfied with the entire review and publication experience. The journal maintains a well-structured and efficient ..."
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"I am fully satisfied with the entire review and publication experience. The journal maintains a well-structured and efficient peer-review system that delivers professional and constructive feedback — the reviewers’ comments were particularly valuable.This journal also pays close attention to details and conducts a thorough review process. It is a fair and objective publication. Moreover, it offers open access without article processing charges, and the whole process is fast. "
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Weng MT, Yao CY, Lin WC, Lai SK, Tung CC, Wang CY, Wong JM, Chen PL, Wei SC. HLA-C*03:04:01 and HLA-B*15:18:01 but not HLA-DQA1*05 associated with anti- tumor necrosis factor antibody formation in Taiwanese inflammatory bowel disease patients. World J Gastroenterol 2025; 31(41): 111745
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"I am deeply honored to have the opportunity to publish in the World Journal of Gastroenterology. The editorial process was ..."
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"I am deeply honored to have the opportunity to publish in the World Journal of Gastroenterology. The editorial process was well-organized, and the peer review comments were helpful in refining our manuscript. The editorial team showed good knowledge of the field and offered useful suggestions. The journal maintains solid academic standards and clear communication throughout the review process. I would strongly recommend WJG to colleagues seeking a reputable platform for publishing high-quality gastroenterology research. "
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Yu J, Yu B, Ge FL, Ren ZG. Pescadillo ribosomal biogenesis factor 1 as a therapeutic target in tumor immunotherapy. World J Gastroenterol 2025; 31(41): 110367
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"One aspect of the submission process at the World Journal of Gastroenterology that I found inconvenient was the way reviewer comments ..."
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"One aspect of the submission process at the World Journal of Gastroenterology that I found inconvenient was the way reviewer comments were handled. Instead of consolidating all reviewers’ comments and requesting a single, comprehensive response, the process involved receiving comments from one reviewer, responding to them, and then receiving additional comments from another reviewer afterward. This step-by-step approach created unnecessary confusion and inefficiency. "
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Han SY, Yang MJ, Lee KJ, Lee J, Park SW. Comparison of clinical outcomes for single- and double-balloon enteroscope-assisted endoscopic retrograde cholangiopancreatography in patients with surgically altered anatomy. World J Gastroenterol 2025; 31(41): 111022
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"I am thoroughly pleased with all key aspects of your journal’s services, including the well-structured forms for the online full-text ..."
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"I am thoroughly pleased with all key aspects of your journal’s services, including the well-structured forms for the online full-text article, the seamless article publication process, the clear provision of academic rules and standards, and the reliable academic misconduct detection report. The reasonable publication period, detailed editing and publishing norms, appropriate duration allocated to peer review, and rigorous anonymous peer review process also meet my full expectations. In particular, the peer review report has been extremely helpful in refining my manuscript, and I am convinced that its feedback is fair and objective, grounded purely in academic merit. "
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Wu JW, Li LP, Chen YS. Effects of bottle gourd moxibustion combined with umbilical therapy for cancer-related incomplete bowel obstruction on inflammatory cytokine levels. World J Gastroenterol 2025; 31(41): 110753
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"This journal has a standardized and fast peer-review process, with professional feedback; it does not charge article processing fees ..."
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"This journal has a standardized and fast peer-review process, with professional feedback; it does not charge article processing fees and is open access; the online publication is fast. Additionally, the journal is highly relevant to our research, has a good reputation in the field, has a standardized and efficient publication process, and aligns with our personal institutional publication strategies. "
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Lv XF, Li RH. Alcohol use-related problems in general hospitals and primary care settings: Screening, intervention, and referral to treatment. World J Psychiatry 2025; 15(11): 108165
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"I am extremely satisfied with my experience publishing in the World Journal of Gastroenterology. The journal demonstrates a high level ..."
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"I am extremely satisfied with my experience publishing in the World Journal of Gastroenterology. The journal demonstrates a high level of credibility and professionalism, with a strong reputation for publishing quality, peer-reviewed research. The peer review process was rigorous, timely, and constructive, and the reviewers’ comments were insightful and helped improve the manuscript substantially. The editorial communication was clear and efficient throughout the process. However, I would like to note that the journal’s request for the finding document posed some challenges, as it contained confidential information that could not be shared. I hope the journal will consider more flexible approaches regarding such materials in future submissions. "
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Alruhaimi RS, Hassanein EHM, Alnasser SM, Ahmeda AF, Althagafy HS, Abd El-Ghafar OAM, Mahmoud AM. Ambroxol mitigates cyclophosphamide-induced liver injury by suppressing TLR-4/NF-κB signaling and oxidative stress and upregulating cytoglobin, TXNRD1 and HMGB1. World J Gastroenterol 2025; 31(35): 108139
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"I am satisfied with the entire review & publication process of the manuscript. The auto-editing of revisions has improved, but ..."
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"I am satisfied with the entire review & publication process of the manuscript. The auto-editing of revisions has improved, but uploading references remains a challenge. The final manuscript is satisfactory. The open access format increases the manuscript’s visibility. I have been contributing articles to the World Journal of Psychiatry for some time, and I look forward to continuing to do so in the future. "
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Bansal H, Chakrabarti S, Grover S. Psychoeducational treatments for obsessive-compulsive disorder: A narrative review emphasizing family-based approaches. World J Psychiatry 2025; 15(11): 110239
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"To the Editorial Team of World Journal of Psychiatry, We are pleased to express our sincere appreciation for the professional and ..."
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"To the Editorial Team of World Journal of Psychiatry, We are pleased to express our sincere appreciation for the professional and efficient handling of our manuscript (Manuscript NO: 110699). The entire editorial process, from submission to revision, was conducted in a timely and well-organized manner. The peer review comments were constructive and insightful, which significantly helped us improve the quality of our work. We are confident that the journal’s commitment to excellence and author support will continue to benefit the scientific community. Thank you for the opportunity to publish in your esteemed journal. Best regards, Jiang-Bo Li On behalf of all co-authors "
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Li JB, Ye XB, Tu XJ. Interaction between anxiety, depression, and low resilience predicts poor prognosis in patients with chronic kidney disease. World J Psychiatry 2025; 15(11): 110699
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"We would like to express our sincere appreciation to the editorial team of the World Journal of Psychiatry for their professional ..."
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"We would like to express our sincere appreciation to the editorial team of the World Journal of Psychiatry for their professional handling of our manuscript. The entire publication process—from initial submission to final publication—was efficient, transparent, and highly supportive. The reviewers’ comments were constructive and insightful, greatly improving the quality of our work. We are also grateful to the editors for their careful coordination and timely communication. It has been a pleasant and rewarding experience to publish with the World Journal of Psychiatry, and we look forward to future collaboration. "
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Huang XL, Chen DF, Wang Y, Zhang YN, Michael N, Ge YS, Wang B. DNA methylation as a new frontier in treating fear-related disorders: A need for careful evaluation. World J Psychiatry 2025; 15(11): 110581
19853 items Read more >>
1
"a fine-needle aspiration (FNA) biopsy, especially one guided by endoscopic ultrasound (EUS-FNA), is a valuable diagnostic tool for ..."
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"a fine-needle aspiration (FNA) biopsy, especially one guided by endoscopic ultrasound (EUS-FNA), is a valuable diagnostic tool for pancreatic tuberculosis. This procedure allows doctors to collect tissue samples to confirm the diagnosis by checking for characteristic signs like granulomas, caseous necrosis, and acid-fast bacilli (AFB) or by using polymerase chain reaction (PCR) to detect the DNA of Mycobacterium tuberculosis. EUS-FNA is especially useful because it can help differentiate pancreatic TB from pancreatic cancer, preventing unnecessary surgery. "
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Nima CL, Wang HG, Zhou Q. Pancreatic tuberculosis: A case report and review of literature. World J Gastroenterol 2025; 31(41): 110398
2
"In this mini-review, the authors described the current understanding of the pathogenesis, diagnosis, and management of hepatic ..."
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"In this mini-review, the authors described the current understanding of the pathogenesis, diagnosis, and management of hepatic hydrothorax. Despite the successes of modern hepatology, the presence of hepatic hydrothorax is associated with poor prognosis and high mortality. Most patients with hepatic hydrothorax are candidates for liver transplantation. In usual clinical practice, the key to the success of their management may be the stratification of the risk of an adverse outcome and the definition of individual therapeutic tactics. A pathogenetically based approach to the choice of pharmacotherapy, as well as optimization of minimally invasive treatment methods, will improve the quality of life and increase the survival rate of this category of patients. In general, the authors provided well-known information."
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Cilia BJ, Haridy J, Raj A, Hannah N. Hepatic hydrothorax as a manifestation of decompensated cirrhosis: An update on current management and future directions. World J Hepatol 2025; 17(10): 110412
3
"Dear Author
There are parameters like MELD score that show the severity of the disease. This important score was not addressed ..."
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"Dear Author
There are parameters like MELD score that show the severity of the disease. This important score was not addressed in the trial. Were the adherent and non-adherent groups had similar MELD scores? Sarcopenia as another important factor that influence cirrhosis out comes. This risk factor was not addressed in this trial. The nutritional status regarding the vitamins and protein intake are among the most important factors that influence cirrhosis out comes. In the future trials considering the variables that influence the patient outcomes should be considered. "
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Loschi TM, Baccan MDTA, Pereira EC, Dellabarba TDLC, Boteon APCS, Boteon YL. Telerehabilitation for frail cirrhotic patients awaiting liver transplant: A safe, effective strategy to improve outcomes. World J Hepatol 2025; 17(10): 110856
4
"Dear Author,
The patient had a history of cirrhosis of the liver based on abdominal CT scan. The data regarding the other causes ..."
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"Dear Author,
The patient had a history of cirrhosis of the liver based on abdominal CT scan. The data regarding the other causes of chronic hepatitis were not included in the draft. Although using herbal medicine could cause the fulminant hepatitis, yet it is a diagnosis of exclusion. In my opinion, the possibility of coexistence of auto immune hepatitis in this case needs more evaluation."
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Zhu XY, Zhao YT, Su CS, Yuan XD, Zhang SG, Nashan B. Acute liver failure caused by alkaloids from traditional Chinese medicine: A case report. World J Hepatol 2025; 17(10): 109575
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"In recent years, artificial intelligence (AI) has brought about a real revolution in various fields of human activity, establishing ..."
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"In recent years, artificial intelligence (AI) has brought about a real revolution in various fields of human activity, establishing itself as a pioneering innovation in modern medical science. In the field of gastroenterology, and in particular colonoscopy, it has contributed significantly by promoting key quality indicators, reducing the rate of human error, and improving the consistency of endoscopist decision-making with high reliability. Reduce human error and improve endoscopists' decision-making consistency in real time, ensuring higher reliability and standardization during the procedure. By optimizing the characterization of endoscopically detected lesions, supporting visual diagnosis, and predicting the depth of infiltration, AI can enable early diagnosis and prevention of colon cancer. The combination of AI with advanced imaging techniques improves the quality of gastroenterologists' training.
However, much remains to be clarified regarding the role of AI in upper and lower gastrointestinal endoscopy. I believe that the official gastroenterological societies of Europe, the USA, and Asia should immediately delve into studying and defining the possibilities, potential risks of the widespread application of the method, and define policies regarding quality assurance, clinician education, data protection, and liability, so that AI successfully complements human intelligence and experience. The innate tendency of people (in this case, endoscopists) to resist adopting these new technologies should not prevail. They can also help validate AI systems in real-world conditions by assessing their performance across a wide range of quality indicators.
I want to congratulate the authors for their excellent work in a promising field."
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Dimopoulou K, Spinou M, Ioannou A, Nakou E, Zormpas P, Tribonias G. Artificial intelligence in colonoscopy: Enhancing quality indicators for optimal patient outcomes. World J Gastroenterol 2025; 31(40): 111499
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"This is very interesting paper.Higher serum gamma-glutamyl transpeptidase (γ-GTP) levels are associated with an increased risk of ..."
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"This is very interesting paper.Higher serum gamma-glutamyl transpeptidase (γ-GTP) levels are associated with an increased risk of pancreatic cystic neoplasms (PCNs) and their malignant progression. However, γ-GTP is not a specific diagnostic marker for these conditions. Its elevation is more indicative of general liver or biliary dysfunction and oxidative stress. Recent large-scale studies have found that people with higher baseline serum γ-GTP levels have a significantly increased risk of being diagnosed with PCNs later on. This suggests γ-GTP could potentially serve as a biomarker for identifying high-risk individuals for surveillance."
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Lee MW, Park JM, Cho IR, Chung KH, Kim BS, Choi JH, Paik WH, Ryu JK, Han K, Lee SH. Serum gamma-glutamyl transferase level is associated with the risk of pancreatic cystic neoplasms: A nationwide retrospective cohort study. World J Gastroenterol 2025; 31(40): 110932
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"Artificial intelligence has brought about a real revolution in various areas of human activities, including medical science. In recent ..."
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"Artificial intelligence has brought about a real revolution in various areas of human activities, including medical science. In recent years, AI has also emerged as a method to support the correct diagnosis and treatment of acute pancreatitis. Some elements of AI, such as machine learning, deep learning, natural language processing, and network pharmacology, seem to significantly facilitate diagnostic and therapeutic decisions in the treatment of patients with acute pancreatitis, through the analysis of clinical records, medical images, laboratory values, genomic data, and physiological signals in real time. AI functions as advanced decision support, enhancing clinical judgment with intelligence derived from diagnostic data, assessing risks to the patient from potential complications, and helping safely predict the disease. The authors also discuss future directions for AI development in the treatment of acute pancreatitis. As emphasized by the authors of this review, today's practical medicine often requires an interdisciplinary approach that integrates clinical experience, computational modeling, and ethical design. These largely theoretical data currently have limited application, especially in developing countries worldwide. For all health systems and in any country where AI is applied, its assistance should consist of improving decision-making through hybrid human-artificial intelligence models. The future looks excellent, although it causes concern and fear to the undersigned."
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Zhang XY, Hu MD, Maimaitijiang D, Wang T, Wang L. Artificial intelligence in pancreatitis: A narrative review on advancing precision diagnosis, prognosis, and therapeutic strategies. World J Gastroenterol 2025; 31(39): 110971
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"This review explores the bidirectional regulation between the gut microbiome and the immune system within the colorectal cancer (CRC) ..."
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"This review explores the bidirectional regulation between the gut microbiome and the immune system within the colorectal cancer (CRC) microenvironment. It highlights how microbial metabolites and immune signaling pathways influence tumor progression, immune evasion, and therapeutic response. Key mechanisms include TLR4 and NLRP3 activation, SCFA modulation, and PD-1 pathway interactions. The authors discuss emerging interventions such as engineered probiotics, FMT, and metabolic vaccines targeting the microbiota-immune axis. Overall, the study provides a comprehensive framework for developing personalized CRC therapies through microbiome modulation."
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Liu XX, Yang B, Tang DX. Bidirectional regulation of the gut microbiome-immune axis in the immune microenvironment of colorectal cancer and targeted interventions. World J Gastrointest Oncol 2025; 17(10): 109503
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"This retrospective two-center study investigates ultrasound features of primary intestinal lymphoma in children and their correlation ..."
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"This retrospective two-center study investigates ultrasound features of primary intestinal lymphoma in children and their correlation with prognosis. Twenty-eight pediatric cases were classified into focal segmental and extensive types based on sonographic findings. Extensive-type lymphoma was associated with significantly elevated LDH levels and poorer outcomes compared to the segmental type. Ultrasound classification and LDH levels showed strong prognostic relevance, while pathological type, age, and treatment modality did not. The study concludes that ultrasound is a valuable tool for diagnosis, classification, and prognosis prediction in pediatric intestinal lymphoma."
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Huang SF, Yang F, Chen WJ, Zhang XH. Ultrasound features of primary intestinal lymphoma in children and their correlation with prognosis: A two-center experiment. World J Gastrointest Oncol 2025; 17(10): 109450
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"This review highlights how lipid metabolic reprogramming drives colorectal cancer (CRC) progression, immune evasion, and therapy ..."
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"This review highlights how lipid metabolic reprogramming drives colorectal cancer (CRC) progression, immune evasion, and therapy resistance. It discusses key alterations in fatty acid synthesis, oxidation, and cholesterol metabolism, as well as the impact of high-fat diets and gut microbiota on the tumor microenvironment. The authors emphasize the role of lipid metabolism in shaping immunosuppressive dynamics and promoting cancer stemness and metastasis. By identifying actionable lipid-related pathways and enzymes, the review proposes novel therapeutic strategies, including combinations with immunotherapy. Overall, it offers a comprehensive and timely framework for advancing precision oncology in CRC."
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Wang CD, Zhang BX, Song J. Lipid metabolic reprogramming in colorectal cancer: Insights to mechanisms and therapeutics. World J Gastrointest Oncol 2025; 17(10): 109398
11
"This multicenter retrospective study analyzed 189 colorectal cancer (CRC) patients admitted to intensive care units (ICUs) across ..."
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"This multicenter retrospective study analyzed 189 colorectal cancer (CRC) patients admitted to intensive care units (ICUs) across 37 cancer-specialized hospitals in China. The 90-day mortality rate was relatively low at 12.2%, with elective surgery and conventional oxygen therapy associated with better outcomes. Chemotherapy history and unplanned ICU transfers were linked to higher mortality, while severity scores like SOFA and APACHE II showed only moderate predictive value. This study is commendable for its large-scale, multicenter design and its focus on a clinically important yet underexplored patient population. By identifying key prognostic factors and highlighting the limitations of current scoring systems, the authors provide valuable insights that can inform ICU admission decisions and personalized care strategies for CRC patients."
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Dong Q, Xia R, Xing XZ, Wang CS, Ma G, Wang HZ, Zhu B, Zhao JH, Zhou DM, Zhang L, Huang MG, Quan RX, Ye Y, Zhang GX, Jiang ZY, Huang B, Xu SL, Xiao Y, Zhang LL, Lin RY, Ma SL, Qiu YA, Zheng Z, Sun N, Xian LW, Li J, Zhang M, Guo ZJ, Tao Y, Zhou XZ, Chen W, Wang DX, Chi JY, Wang DH, Liu KZ. Intensive care unit outcomes and prognostic factors of colorectal cancer. World J Gastrointest Oncol 2025; 17(10): 108539
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"This review highlights the link between ulcerative colitis (UC) and colitis-associated colorectal cancer (caCRC), emphasizing how ..."
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"This review highlights the link between ulcerative colitis (UC) and colitis-associated colorectal cancer (caCRC), emphasizing how chronic inflammation drives cancer development. It outlines key molecular pathways, immune responses, and microbiota changes involved in this process, and discusses current strategies for surveillance, chemoprevention, and surgical management. The authors advocate for precision medicine approaches to improve early detection and personalized care. The manuscript is commendable for its comprehensive integration of molecular and clinical insights. By combining updated surveillance guidelines with emerging biomarker research, it offers a forward-thinking framework that can guide more effective prevention and treatment strategies for caCRC in UC patients."
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Catalano M, Mini E, Nobili S, Vascotto IA, Ravizza D, Amorosi A, Tonelli F, Roviello F, Roviello G, Nesi G. Ulcerative colitis and colorectal cancer: Pathogenic insights and precision strategies for prevention and treatment. World J Gastrointest Oncol 2025; 17(10): 108514
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"1 Ethics: Not applicable
2 Methods: Case report that the manuscript was prepared and revised according to the CARE Checklist ..."
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"1 Ethics: Not applicable
2 Methods: Case report that the manuscript was prepared and revised according to the CARE Checklist (2016).
3 Results: case sharing of case presentation, findings and images.
4 Figures and tables: The author provides perfect images which is good quality and easily understandable plus interesting findings.
5 Biostatistics: Not applicable
6 References: Record the latest references which are important in this field and related to the scientific problems and case addressed in the study.
7 Language: The language in article correctly, clearly and concisely express the information. No grammatical and language mistakes.
8 Caveats or drawbacks: Not detected"
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Wang WQ, Yang JP, Dong JW, Chen YB. Misdiagnosis of Crohn’s disease as appendicitis: A case report. World J Gastrointest Surg 2025; 17(9): 108348
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"1 Ethics: Not applicable
2 Methods: Case report that the manuscript was prepared and revised according to the CARE Checklist ..."
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"1 Ethics: Not applicable
2 Methods: Case report that the manuscript was prepared and revised according to the CARE Checklist (2016).
3 Results: case sharing of case presentation, findings and images.
4 Figures and tables: The author provides good images which is good quality and easily understandable. Can be better figures intra-operative
5 Biostatistics: Not applicable
6 References: Record the latest references which are important in this field and related to the scientific problems and case addressed in the study.
7 Language: The language in article correctly, clearly and concisely express the information. No grammatical and language mistakes.
8 Caveats or drawbacks: Not detected"
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Zhang J, Sun S, Zheng S, Ma YY, Chen G. Gastric adenomyoma in children: A case report. World J Gastrointest Surg 2025; 17(9): 107297
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"1 Ethics: Not applicable
2 Methods: Case report that the manuscript was prepared and revised according to the CARE Checklist ..."
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"1 Ethics: Not applicable
2 Methods: Case report that the manuscript was prepared and revised according to the CARE Checklist (2016).
3 Results: case sharing of case presentation, findings and images.
4 Figures and tables: The author provides perfect images which is good quality and easily understandable.
5 Biostatistics: Not applicable
6 References: Record the latest references which are important in this field and related to the scientific problems and case addressed in the study.
7 Language: The language in article correctly, clearly and concisely express the information. No grammatical and language mistakes.
8 Caveats or drawbacks: Not detected"
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Moon YJ, Lee SH. Inferior mesenteric arteriovenous fistula: Two case reports. World J Gastrointest Surg 2025; 17(9): 107139
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"1 Ethics: Not applicable
2 Methods: Case report that the manuscript was prepared and revised according to the CARE Checklist ..."
[Read more]
"1 Ethics: Not applicable
2 Methods: Case report that the manuscript was prepared and revised according to the CARE Checklist (2016).
3 Results: case sharing of case presentation, findings and images.
4 Figures and tables: The author provides good images which is good quality and easily understandable. need arrow in intra-operative image
5 Biostatistics: Not applicable
6 References: Record the latest references which are important in this field and related to the scientific problems and case addressed in the study.
7 Language: The language in article correctly, clearly and concisely express the information. No grammatical and language mistakes.
8 Caveats or drawbacks: Not detected"
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Ahunayizhi A, Zhang XL, Chen Q, Wang H, Ding G, Akumuo S, Wang XX, Ruan XJ. Laparoscopic management of gallstones in a duplicate gallbladder with double cystic ducts: A case report. World J Gastrointest Surg 2025; 17(9): 110796
17
"1 Ethics: Not applicable
2 Methods: Case report that the manuscript was prepared and revised according to the CARE Checklist ..."
[Read more]
"1 Ethics: Not applicable
2 Methods: Case report that the manuscript was prepared and revised according to the CARE Checklist (2016).
3 Results: case sharing of case presentation, findings and images.
4 Figures and tables: The author provides not medical photograph especially resected specimens photo.
5 Biostatistics: Not applicable
6 References: Record the latest references which are important in this field and related to the scientific problems and case addressed in the study.
7 Language: The language in article correctly, clearly and concisely express the information. No grammatical and language mistakes.
8 Caveats or drawbacks: Not detected"
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Guo Q, Lu HY, Lyu H, Tian H, Zhao Q, Zheng YC. Complete appendiceal intussusception and appendiceal mucinous tumor: A case report and review of literature. World J Gastrointest Surg 2025; 17(9): 109320
18
"This is a very interesting analysis and "observational" association between BMI and ALF. This work supports the knowledge about obesity ..."
[Read more]
"This is a very interesting analysis and "observational" association between BMI and ALF. This work supports the knowledge about obesity and the worldwide problem it represents as a health problem. With all due respect, this work lacks further analysis (hypothesis) on how this increased BMI contributes to organ failure. Further analysis should focus not only on organ (liver in this case) failure but on gastrointestinal symptomatology (effects) in general."
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Krishnan A, Khan S, Gips J, Alqahtani SA, Vaidya D, Liu YS, Kim A, Su A, Gurakar A, Hamilton JP, Woreta TA. Body mass index and its association with clinical outcomes in acute liver failure. World J Clin Cases 2025; 13(30): 109212
19
"1 Ethics: Ethical approval is stated as obtained from a relevant committee, meeting requirements.
2 Methods: Experimental methods ..."
[Read more]
"1 Ethics: Ethical approval is stated as obtained from a relevant committee, meeting requirements.
2 Methods: Experimental methods (cell culture, molecular/functional assays, microscopy) are standard, well-described, and repeatable via established protocols/citations.
3 Results: Results are authentic (consistent dose-effects, clear molecular data). The hypothesis that Prdx1 inhibits CRC via pyroptosis is partially validated (robust in vitro support, but lacks in vivo/clinical evidence for universal significance). Notably, the loading control (β-actin) appears uneven between N17 and T17 samples, which may raise minor concerns about sample loading consistency. While the study uses three cell lines to validate findings—enhancing data volume and credibility—it would further strengthen translational relevance if the authors validated Prdx1’s effects using patient-derived organoids (PDOs), which better recapitulate in vivo tumor biology.
4 Figures and tables: Figures are well-constructed with clear annotations, and tables present data effectively. However, most images rely heavily on black-and-white visuals, which could be aesthetically enhanced (e.g., using color coding for different groups or molecular targets) to improve readability and visual communication of key results.
5 Biostatistics: Statistical analyses are appropriately applied, with accurate p-values and data visualization (error bars, sample sizes).
6 References: Citations include key recent works on pyroptosis, inflammasomes, and CRC; citations are scientific, relevant, and not overly self-referential.
7 Language: Language is clear, concise, and grammatically correct.
8 Caveats or drawbacks: Animal-level experimental validation is insufficient; currently, only tumor size is assessed. Supplementing with detection of relevant proteins (e.g., NLRP3, GSDMD, caspase-1) or gene expression in tumor tissues from animal models would more be much better.
In summary, this study is well-conducted, utilizing paired tumor and adjacent non-tumor tissues from 20 patients, which enhances its clinical relevance. To further extend the current findings, it would be valuable for the authors to employ clinical specimens for establishing patient-derived organoids (PDOs) or patient-derived xenograft (PDX) models in future work, thereby validating the results in an in vivo context. Additionally, given the involvement of immunogenic cell death (ICD) discussed in the study, subsequent research could also explore the efficacy and underlying mechanisms related to tumor immunity.
"
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He Y, Liu J, Zhou N, Xie LX, Jiang YF, Chen CL. Peroxiredoxin 1 inhibits tumorigenesis by activating the NLRP3/GSDMD pathway to induce pyroptosis of colorectal cancer cells. World J Gastroenterol 2025; 31(36): 111557
20
"This large-scale, 20-year retrospective study by Huang et al. is a significant achievement, successfully establishing the first ..."
[Read more]
"This large-scale, 20-year retrospective study by Huang et al. is a significant achievement, successfully establishing the first genome-wide polygenic risk score (PRS) for diabetic retinopathy (DR) in a Taiwanese Han population. The study's key contribution is demonstrating that a high PRS is strongly associated not just with DR incidence, but more critically, with disease severity requiring interventions like laser treatment or surgery. This suggests the PRS could be a valuable tool for identifying patients needing more intensive monitoring.
Despite these strengths, the study highlights a crucial unresolved issue: the clinical utility of the PRS beyond existing risk factors. The central question remaining is whether this genetic information provides actionable predictive power over and above standard clinical data such as HbA1c and diabetes duration. Furthermore, the findings' generalizability to other ethnicities is yet to be determined, as the study was confined to a specific Asian population.
Therefore, the essential next step is to conduct prospective validation studies aimed at creating an integrated risk model. Such a model would combine the PRS with established clinical variables to definitively quantify its added value in personalizing DR screening strategies and improving patient outcomes."
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Huang YC, Liao WL, Lin HJ, Huang YT, Chang YW, Yang JS, Weng AL, Tsai FJ. Polygenic risk score for predicting diabetic retinopathy in patients with type 2 diabetes: A twenty-year follow-up study. World J Diabetes 2025; 16(10): 110138
15830 items Read more >>
Peer-Reviewers and Manuscript Statistics
- Editorial board members
- 2264
- Peer-reviewers
- 34491
- Manuscripts received today
- 8
- Manuscript reviews today
- 16
- Unhandled manuscripts today
- 154
- Active peer-reviewers today
- 2431
- Reviewer acceptance today
- 44
- Reviewer refusals today
- 54
- Total accepted manuscripts
- 38434
- Total rejected manuscripts
- 43576
- Total peer-reviewers
- 4473322
- Total submissions
- 36493
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10047 items Read more >>
72985 items Read more >>
1
"The authors presented a case of pancreatic tuberculosis and provided a detailed analysis of the diagnostic process, which holds ..."
[Read more]
"The authors presented a case of pancreatic tuberculosis and provided a detailed analysis of the diagnostic process, which holds significant reference value for the diagnosis of similar cases. However, the report lacks an in-depth discussion and evaluation of the treatment approach and therapeutic strategy employed in this case, thereby limiting its applicability in guiding clinical management of analogous conditions. Consequently, the inclusion of a comprehensive treatment plan would substantially enhance the clinical utility and overall contribution of this case report. "
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Nima CL, Wang HG, Zhou Q. Pancreatic tuberculosis: A case report and review of literature. World J Gastroenterol 2025; 31(41): 110398
2
"This study has compared several computational methods to be used in the predication of prognosis for acute variceal bleeding in ..."
[Read more]
"This study has compared several computational methods to be used in the predication of prognosis for acute variceal bleeding in cirrhosis patients. Author claimed that the convolution network by their efforts displayed the best effect in the outcomes analysis rather than another methods. However, the specific features in different subgroups with data presentations using AI or other computational methods lacked in the full analysis to be performed in the compared computation process. This means that this study only provides the end result for supporting their analysis as they wanted. In addition, the standard between high and low risk group presented to differ significantly without clinical parameters in this study. "
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Xiang Y, Yang N, Zheng TL, Huang YF, Liu TY, Ma DQ, Hu SJ, Zhang WH, Xiang HL, Zhang LY, Yuan LL, Wang X, Dang T, Zhang G, Wu B, Peng LJ, Gao M, Xia DL, Liu ZB, Li J, Song Y, Zhou XQ, Qi XS, Zeng J, Tan XY, Deng MM, Fang HM, Qi SL, He S, He YF, Ye B, Wu W, Shao JB, Wei W, Hu JP, Yong X, He CH, Bao JL, Zhang YN, Ji R, Bo Y, Yan W, Li HJ, Li SL, Geng S, Zhao L, Liu B, Qi XL. Development of a deep learning model for guiding treatment decisions of acute variceal bleeding in patients with cirrhosis. World J Gastroenterol 2025; 31(41): 111361
3
"This article is a well-conducted clinical study that elucidates the psychological profiles of patients undergoing esophagectomy for ..."
[Read more]
"This article is a well-conducted clinical study that elucidates the psychological profiles of patients undergoing esophagectomy for esophageal cancer. Its core contributions lie in: 1. Demonstrating a significant negative correlation among anxiety, depression, and mindfulness, advancing understanding of the mind–body interaction in surgical oncology; 2. Identifying key demographic and clinical risk factors that shape postoperative emotional outcomes, thereby guiding individualized psychological assessment and intervention. By linking psychometric evaluation with perioperative management, this study offers a valuable reference for integrating mindfulness-based strategies into holistic recovery pathways. "
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Deng X, Hu YH, Xiong YJ, Mao N, Hong B, He G. Correlation of anxiety and depression with mindfulness in esophageal cancer patients undergoing esophagectomy and analysis of risk factors. World J Psychiatry 2025; 15(9): 104813
4
"The article is well-written and demonstrates a clear and logical flow from the introduction to the conclusion. The research objectives ..."
[Read more]
"The article is well-written and demonstrates a clear and logical flow from the introduction to the conclusion. The research objectives are clearly stated, and the study design appropriately addresses the research questions. The literature review is comprehensive and up to date, providing a strong theoretical foundation for the study. The methodology is well-described, enabling replication, and the data analysis is appropriate and rigorous. The discussion effectively interprets the findings in relation to existing studies, and the conclusions are supported by the results. Overall, this is a good-quality manuscript that makes a valuable contribution to the field. "
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Yanti L, Surtiningsih, Ardiyani FHN, Sekarini NNAD, Susanti D, Mustaan, Murniati, Supriyadi, Santosa A. Long-term consequences of unintended pregnancy: Impacts on early childhood growth and development in a multicenter study. World J Clin Pediatr 2025; 14(4): 107346
5
"The retrospective study by Huang and colleagues provides valuable insights into the prevalence and clinicopathological significance ..."
[Read more]
"The retrospective study by Huang and colleagues provides valuable insights into the prevalence and clinicopathological significance of HER2 expression in upper tract urothelial carcinoma. Their finding that HER2 overexpression is strongly associated with high tumor grade but not with conventional markers of disease progression underscores the distinct biological behavior of UTUC compared to bladder cancer. This work is particularly relevant as it highlights a potential therapeutic target in a disease with limited treatment options. However, the clinical implications of HER2 expression in UTUC must now be reinterpreted in light of the practice changing results presented at the ESMO Congress 2025. The phase 3 RC48 C016 trial demonstrated for the first time that a combination of the anti HER2 antibody drug conjugate disitamab vedotin and the anti PD1 immunotherapy toripalimab significantly outperforms standard platinum based chemotherapy in the first line treatment of HER2 expressing locally advanced or metastatic urothelial carcinoma. The results are striking: Progression free survival was nearly doubled (13.1 months versus 6.5 months; HR = 0.36); Overall survival showed a remarkable improvement (31.5 months versus 16.9 months; HR = 0.54); Benefits were consistent across all HER2 expression levels (IHC 1+, 2+, and 3+); and The combination also exhibited a more favorable safety profile. These findings represent a paradigm shift. For the first time, a biomarker directed strategy has proven superior to chemotherapy in the first line setting for advanced UC. Given that HER2 expression is found in up to 70% of urothelial carcinomas, this new regimen could benefit a majority of patients. In this context, the work by Huang et al gains even greater importance. Their observation that nearly half of UTUC tumors (46.2%) show HER2 positivity especially in high grade disease suggests that a substantial proportion of UTUC patients may be candidates for this novel, highly effective combination therapy. The authors call for clinical trials evaluating HER2 targeted therapies in high grade, HER2 positive UTUC is now more urgent than ever. Future studies should urgently validate the efficacy of disitamab vedotin plus toripalimab in UTUC specific cohorts and explore its potential in earlier disease stages. The era of biomarker driven therapy for urothelial carcinoma has arrived, and HER2 is firmly at its center. Reference: Sheng X, He Z, Zhang G, et al. Primary results from the phase 3 RC48 C016 trial: Disitamab vedotin plus toripalimab versus chemotherapy as first line treatment for HER2 expressing locally advanced or metastatic urothelial carcinoma. Annals of Oncology 2025;36(Supplement 3):S1573 S1574. "
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Huang L, He J. Human epidermal growth factor receptor 2 overexpression is associated with high-grade tumors in upper tract urothelial carcinoma. World J Clin Oncol 2025; 16(10): 110047
6
"This review on the gut-liver axis provides a highly insightful and comprehensive exploration of the evolving role of the microbiome ..."
[Read more]
"This review on the gut-liver axis provides a highly insightful and comprehensive exploration of the evolving role of the microbiome in liver diseases. It successfully ties together mechanisms of microbiome dysbiosis with the pathogenesis of various hepatic conditions, including metabolic dysfunction-associated liver disease, cirrhosis, and cholangiopathies. The authors delve into how imbalances in gut microbiota disrupt bile acid metabolism, increase intestinal permeability, and promote inflammation, which in turn drives liver injury. The article's coverage of emerging treatment options, including bacteriophage therapy and genetic engineering of gut microbes, is particularly noteworthy, reflecting a growing understanding of the microbiome's potential as a therapeutic target. This forward-thinking approach adds substantial clinical relevance, making the article valuable for researchers and clinicians looking to integrate microbiome-based therapies into practice. "
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Anis MA, Shahid Y, Majeed AA, Abid S. Microbiome and gut-liver interactions: From mechanisms to therapies. World J Gastroenterol 2025; 31(40): 111409
7
"This study offers a compelling and innovative exploration of colonoscopy quality, addressing the critical interplay between insertion ..."
[Read more]
"This study offers a compelling and innovative exploration of colonoscopy quality, addressing the critical interplay between insertion time and withdrawal duration to optimize adenoma detection rate (ADR). The proposed "insertion-to-withdrawal" paradigm marks a significant departure from fixed withdrawal time standards, advocating for a personalized approach—a novel and practical advancement. The development of a Shiny app to deliver real-time, individualized guidance further enhances its clinical relevance, providing endoscopists with a valuable tool to improve outcomes. Several aspects warrant deeper consideration. First, the hybrid SVM-XGBoost model's modest discriminative performance (AUC ≈ 0.64) suggests limitations in its current predictive power, likely due to unaddressed variables such as bowel preparation nuances, insertion difficulty, or segment-specific inspection times. Expanding the dataset with multicenter inputs and incorporating these factors could refine its accuracy. Second, while insertion time serves as a proxy for procedural complexity, its validation against objective difficulty scales or video analysis would bolster the mechanistic basis of the findings. Third, the personalized strategy’s generalizability remains untested; prospective multicenter validation across diverse demographics, endoscopist expertise, and regions is essential. Finally, evaluating real-world app adoption and its impact on ADR adherence would provide critical evidence of its efficacy. Overall, this study lays a robust foundation for data-driven personalization in endoscopy, moving beyond uniform metrics. With further refinement and validation, it has the potential to transform clinical practice significantly. "
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Xu BX, Xu CZ, Zhang HY, Chen XJ, Wei BN, Yang C. Personalizing withdrawal time by insertion time to achieve target adenoma detection rate in colonoscopy. World J Gastroenterol 2025; 31(38): 111364
8
"I want to congratulate Yang-Yang Xiong for publishing an excellent study comparing Endoscopic Clip or EUS Coil-assisted glue for ..."
[Read more]
"I want to congratulate Yang-Yang Xiong for publishing an excellent study comparing Endoscopic Clip or EUS Coil-assisted glue for gastric varices. The authors have shown that EUS-guided therapy is more costly and involves high operating time; however, it has similar technical eradication of gastric varices and re-bleeding rates even in larger varices > 4 cm. The size comparison may not be uniform, as the Endoscopic group measured by endoscopic appearance, which may be as accurate as EUS measurement. The Authors have shown only a 5-day rebleeding rate; adding delayed rates could have been more impactful. There is a discrepancy in the table and image regarding post-injection ulcer; the Image shows a post-glue ulcer in both groups, whereas in the table, it was zero; these typographical errors could have been avoided. The eradication time frame is not mentioned; whether it is immediately or 5 days, as the rebleeding rate or any other time frame is not clear. The Follow up endoscopy data is not given; if done even after CT showing eradication of varices or for other GI Bleeding, the time at which it was done was not mentioned, and the procedure done when eradication is not established is also not given. Despite these limitations the study has provided a meaning ful comparison and can change my practice "
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Xiong YY, Li DW, Zhou TY, Ma H, Gao JG, Shen Z, Xu CF, Yu CH. Clip-assisted endoscopic cyanoacrylate injection vs endoscopic ultrasound-guided coil and cyanoacrylate injection for gastric varices: A propensity score-matched study. World J Gastroenterol 2025; 31(38): 111363
9
"This article provides a timely and valuable overview of emerging therapeutic strategies for managing IBD. The integration of physical ..."
[Read more]
"This article provides a timely and valuable overview of emerging therapeutic strategies for managing IBD. The integration of physical exercise and VNS as adjuncts to traditional pharmacological treatments is particularly relevant, as clinicians are increasingly seeking non-invasive and complementary approaches to help manage chronic inflammatory diseases. The article does an excellent job of explaining how these interventions may improve autonomic regulation, reduce inflammation, and promote gut health, which are all essential factors in managing the symptoms and progression of IBD. The focus on the vagus nerve’s role in regulating the immune system through the cholinergic anti-inflammatory pathway presents an interesting potential for VNS as a therapeutic tool. The idea that VNS could restore normal immune function, protect the intestinal barrier, and improve the composition of the gut microbiota is compelling, especially for patients who do not respond adequately to conventional treatments. This could open new avenues for clinical practice, offering patients a holistic approach to managing IBD. However, one of the challenges noted in the article is the variability in response to these non-pharmacological interventions. The review highlights how factors such as exercise intensity, duration, and individual patient factors can influence outcomes. This reflects a common issue in clinical practice, where personalized approaches are often required to determine the best intervention for a given patient. While the evidence for the benefits of physical exercise and VNS in IBD is promising, further studies are needed to establish standardized protocols and validate these therapies in diverse patient populations. The inclusion of vagotomy as a counterpoint to VNS and exercise also brings an important clinical consideration into focus. The article explains how vagotomy, by disrupting the vagal pathway, may exacerbate intestinal inflammation and worsen IBD symptoms. This serves as a reminder of the delicate balance between parasympathetic and sympathetic nervous system function and the potential risks of interfering with this balance in patients with chronic inflammatory conditions. "
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da Silva ACA, Severo JS, dos Santos BLB, Soares HS, Martins JA, Lima RSP, Gadelha KKL, Torres-Leal FL, Correia-de-Sá P, Magalhães PJC, Santos AA, da Silva MTB. Role of physical exercise, vagal nerve stimulation, and vagotomy in inflammatory bowel disease. World J Gastroenterol 2025; 31(38): 111252
10
"This article offers a thorough and insightful overview of the transformative potential of multimodal AI in gastroenterology and ..."
[Read more]
"This article offers a thorough and insightful overview of the transformative potential of multimodal AI in gastroenterology and hepatology. The application of AI across various clinical areas—from early diagnosis to precision treatment—holds great promise. However, the limitations in current AI models—such as lack of data standardization, poor model interpretability, and the need for large-scale, multi-center trials to validate findings—are all issues that would resonate with healthcare professionals. It is crucial for the clinical community to address these issues to ensure that AI technologies can be seamlessly integrated into practice without compromising patient safety or clinical outcomes. "
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Wu YM, Tang FY, Qi ZX. Multimodal artificial intelligence technology in the precision diagnosis and treatment of gastroenterology and hepatology: Innovative applications and challenges. World J Gastroenterol 2025; 31(38): 109802
11
"Gestational diabetes (GD) is a complex disorder with metabolic, inflammatory, genetic, and fetoplacental unit display. The screening ..."
[Read more]
"Gestational diabetes (GD) is a complex disorder with metabolic, inflammatory, genetic, and fetoplacental unit display. The screening is based on oral glucose tolerance tests (OGTT) (one-step and two-step), OGTT is limited by low sensetivity. I addition, it is combersome test and the recommendations and cut-off varied significantly between International Organization. GD is common and is associated with poor maternal and fetal outcomes and the development of type 2 diabetes. The intergration of metabolic, inflammatory, genetic, urinary, and placental biomarkers is highly relevant for the personalized approach among various women. The article is of great interset worldwide, I am very thrilled to write and editorial on this interesting manuscript. Hyder Mirghani, Professor of Internal Medicine and Endocrine, University of Tabuk, Saudi Arabia "
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Kaymak D, Ozgu-Erdinc AS. Advances in gestational diabetes mellitus screening: Emerging trends and future directions. World J Diabetes 2025; 16(10): 111309
12
"Hu et al. (World J Gastroenterol. 2025;31:109528) presented a multicenter study evaluating image-guided thermal ablation (IGTA) for ..."
[Read more]
"Hu et al. (World J Gastroenterol. 2025;31:109528) presented a multicenter study evaluating image-guided thermal ablation (IGTA) for oligometastatic colorectal cancer (CRC) with lung involvement. Among 336 patients treated between 2014 and 2022, the 3- and 5-year overall survival rates were 59.5% and 41.0%, respectively, demonstrating meaningful long-term benefit. Extrapulmonary metastases, particularly in the bone and abdominal cavity, significantly worsened outcomes, whereas patients with liver-only metastases had comparatively favorable survival. Elevated tumor markers (CEA, CA19-9), greater tumor burden, and absence of systemic therapy were adverse prognostic factors. Notably, combining IGTA with systemic therapy improved overall survival. This study underscores IGTA as a viable, minimally invasive treatment for patients with oligometastatic CRC and highlights the prognostic relevance of metastatic distribution in guiding personalized therapy. "
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Hu XF, Dong XJ, Gu XY, Hu JH, Li XH, Zhao FH, Xia XW, Fan HJ, Xu SF. Extrapulmonary metastases impact survival outcomes of thermal ablation for colorectal lung oligometastases: A multicenter study. World J Gastroenterol 2025; 31(38): 109528
13
"Hyperuricemia and high density lipoproteins are imprortant metabolic and inflammatory biomarkers, they are easy to obtain. In ..."
[Read more]
"Hyperuricemia and high density lipoproteins are imprortant metabolic and inflammatory biomarkers, they are easy to obtain. In addition, they are among the cardiovascular risk factors (among other ) and are component of the metabolic syndrome. Depression and tpe 2 diabetes are common health disorders with significant burden on the patients, healthcare system, and the community. When the above diseases present together they exacerbate each other serious consequences. Assessing the uric acid-to-high-density lipoprotein cholesterol ratio in diabetes and psychological disease is highly relevant because they are attainable and the literature on these important parameters is scarce. Thank you very much for the invitation and I would like to publish a letter to the Editor on this interesting topic. "
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Xu H, He DJ, Luo C, Yu XM, Duan CZ, Sun D, Wu DJ, Mao XQ, Jiang WF. Association between uric acid to high-density lipoprotein ratio and mental health symptoms in people with type 2 diabetes. World J Diabetes 2025; 16(10): 110211
14
"Cong et al. deliver a thorough and insightful overview of stem cell–driven cartilage regeneration, addressing the interdisciplinary ..."
[Read more]
"Cong et al. deliver a thorough and insightful overview of stem cell–driven cartilage regeneration, addressing the interdisciplinary progress achieved across biomaterials, cellular therapies, and translational research. Their review integrates recent developments in scaffold engineering, stem cell selection, and in vivo regeneration strategies, making it a valuable guide for researchers in this developing field. However, a few key aspects require more in-depth discussion to fully analyse the field’s complexity and clinical translation. For instance, extracellular vesicles—emerging as central mediators of regenerative signaling—warrant more detailed explanation regarding their standardization and underlying mechanisms. Expanding coverage of these areas would improve the depth of the review and strengthen its guidance toward improving reproducibility, safety, and durability in hyaline cartilage repair strategies based on stem cells. Overall, this comprehensive review by Cong et al. highlights that stem cell-based cartilage regeneration is a rapidly advancing and highly promising field, successfully bridging biological strategies and innovative engineering to offer definitive clinical solutions for challenging joint and cartilage defects. "
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Cong B, Zhang FH, Zhang HG. Stem cell-based cartilage regeneration: Biological strategies, engineering innovations, and clinical translation. World J Stem Cells 2025; 17(9): 108523
15
"This manuscript is well-written and well-prepared. The previous history of adjuvant chemotherapy might have an impact on the ..."
[Read more]
"This manuscript is well-written and well-prepared. The previous history of adjuvant chemotherapy might have an impact on the oligometastatic disease, particularly in colorectal cancer patients.For the long-term follow-up, this current modality of treatment should be considered as one of the options in giving the multimodality treatment in this case. The methods is already clear. "
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Hu XF, Dong XJ, Gu XY, Hu JH, Li XH, Zhao FH, Xia XW, Fan HJ, Xu SF. Extrapulmonary metastases impact survival outcomes of thermal ablation for colorectal lung oligometastases: A multicenter study. World J Gastroenterol 2025; 31(38): 109528
16
"This study explored that the method of thermal therapy displayed a beneficial role in the prognosis of oligometastatic colorectal ..."
[Read more]
"This study explored that the method of thermal therapy displayed a beneficial role in the prognosis of oligometastatic colorectal lung metastases in patients. It should present the histology features including clinical tumor formation and CT images especially in the determination of different tumor size and outcomes under patients after treatment as author mentioned in this study. In addition, the numbers of distinct groups used for comparison performed a large difference in the statistical analysis. "
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Hu XF, Dong XJ, Gu XY, Hu JH, Li XH, Zhao FH, Xia XW, Fan HJ, Xu SF. Extrapulmonary metastases impact survival outcomes of thermal ablation for colorectal lung oligometastases: A multicenter study. World J Gastroenterol 2025; 31(38): 109528
17
"Recent research has uncovered fascinating insights into how a protein called FLOT1 drives liver cancer growth. Scientists found that ..."
[Read more]
"Recent research has uncovered fascinating insights into how a protein called FLOT1 drives liver cancer growth. Scientists found that FLOT1 disrupts normal cellular processes by triggering stress in the Golgi apparatus, essentially giving cancer cells the green light to grow and spread more aggressively. While these findings are exciting and point to FLOT1 as a promising target for new cancer treatments, we still need clinical trials to validate them in patients. Despite this limitation, the study represents a meaningful step forward in our understanding of liver cancer and how we might fight it more effectively in the future. "
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Mazziotta C, Rotondo JC. Unraveling the role of flotillin-1 in driving hepatocellular carcinoma progression through transcription factor E3-mediated Golgi stress response. World J Gastroenterol 2025; 31(38): 112489
18
"Machine Learning in Surgical Decision-Making and Non-Surgical Treatment of Alveolar Echinococcosis Fengying liu,Yongfang Xie Introduce ..."
[Read more]
"Machine Learning in Surgical Decision-Making and Non-Surgical Treatment of Alveolar Echinococcosis Fengying liu,Yongfang Xie Introduce Alveolar Echinococcosis (AE) is a chronic, progressive liver disease caused by the ingestion of Echinococcus multilocularis larvae, with foxes and wild dogs as definitive hosts and rodents as intermediate hosts1. It typically centers in the liver, slowly spreading and metastasizing, with an incubation period lasting 5 to 15 years. Due to early non-specific symptoms such as fever and weight loss, patients are often difficult to diagnose in the early stages. In the later stages, continuous asexual reproduction of Echinococcus multilocularis and severe inflammatory granulomatous infiltration around the parasite lead to widespread fibrosis and necrosis. Without timely treatment, the mortality rate of patients can reach 90% within 10 years1. Currently, radical surgery combined with adjuvant chemotherapy is the only curative treatment method2. However, most patients are diagnosed at advanced stages, missing the optimal timing for liver resection. Ex vivo liver resection and liver autotransplantation (ELRA)3 offer hope for these patients, but traditional surgical decision-making often relies on the clinical experience of surgeons, which can be subjective and prone to bias. In recent years, machine learning has made significant progress in the medical field, especially in disease prediction, treatment selection, and clinical diagnosis, showing tremendous potential for development. By processing large amounts of clinical data, machine learning uncovers complex underlying relationships and assists doctors in making more accurate and objective decisions. Against this backdrop, I carefully reviewed the study published by Da-Long Zhu et al., and found that in the treatment of Alveolar Echinococcosis (HAE), machine learning not only aids in surgical decision-making but also provides valuable support for patients undergoing non-surgical treatments, driving the development of precision medicine4. 1.The Advantages and Challenges of Machine Learning in the Explainability of Surgical Decision-Making for HAE 1.1 Innovative Analysis of Machine Learning Da-Long Zhu et al. conducted a retrospective cohort study based on data from the First Affiliated Hospital of Xinjiang Medical University, including 710 patients, of whom 545 underwent liver resection and 165 underwent ex vivo liver resection and ELRA. The authors innovatively applied three feature selection techniques—recursive feature elimination, minimum redundancy maximum relevance, and LASSO regression—with cross-validation to enhance the model. Ultimately, they identified 10 key features from the extensive clinical data, including lesion size, vascular invasion type, bile duct invasion degree, white blood cell count, platelet count, hemoglobin, indirect bilirubin, serum creatinine, γ-glutamyl transferase, and prothrombin time. These features are closely related to the prognosis of HAE and provide important data support for surgical decision-making. Da-Long Zhu et al. systematically compared the performance and explainability of 11 machine learning models, ultimately selecting the XGBoost model and using Bayesian optimization for hyperparameter tuning.XGBoost5,as an efficient ensemble learning algorithm, demonstrates strong predictive ability in various classification and regression tasks. Model evaluation showed an AUC of 0.935 for the training set and 0.734 for the validation set, with a sensitivity of 93.6% and a specificity of 90.9%. Both the calibration curve and decision curve displayed good clinical utility, effectively predicting whether a patient is suitable for liver resection or ELRA. Furthermore, XGBoost, with its ensemble learning characteristics, reduces the risk of overfitting, providing a stable decision-making tool. To improve the interpretability of the model, Da-Long Zhu et al. employed the SHAP analysis method5 to explain the contribution of each feature to the prediction. Further analysis of the results revealed that vascular invasion type is a key factor in choosing ELRA, while indicators such as platelet count, prothrombin time, and hemoglobin reflect the patient's coagulation function, liver reserve, and inflammatory status. For instance, when significant invasion of the hepatic vein and inferior vena cava is present, the choice of ELRA is more likely, whereas for patients with no vascular invasion or only portal vein involvement, liver resection is preferred. Through SHAP analysis, the model's prediction process became more transparent, enhancing clinicians' trust in the model. 1.2 Limitations and Challenges of the Model It is commendable that Da-Long Zhu et al. accurately identified the clinical decision-making challenges in the surgical treatment of AE and achieved satisfactory results. However, the model still has some limitations. First, the sample size is relatively small, and the data comes from a single source, which may not fully represent patients from different regions or healthcare settings. Secondly, imaging examinations, such as CT scans, are an important tool for diagnosing HAE. However, the study did not conduct a deeper analysis and evaluation of the quantitative features extracted from imaging omics data, such as tumor morphology, texture, and other imaging features6. According to the research by Yener Aydin et al7, HAE often presents with characteristics such as pulmonary nodules, lesions, cavities, and metastatic tumors in imaging. In clinical practice, small solid nodules are easily confused with malignant tumors. Machine learning can help identify the differences and make accurate judgments. In addition to the XGBoost model used by Da-Long Zhu et al., other machine learning models also have their advantages in clinical prediction tasks. To facilitate the rational selection and comparison of models in this field, the following summary is provided (Table 1). Table 1 Model Advantages Limitations XGBoost8 Robust performance, accurate predictions, and comprehensive functionality, suitable for medium-sized data Slower training speed; risk of overfitting, requires regularization control LightGBM9 Extremely fast training speed, high memory efficiency, suitable for large-scale data Higher risk of overfitting on small datasets CatBoost10 Excellent handling of categorical features, high prediction accuracy, fast training speed, strong anti-overfitting ability Lower model flexibility TabNet11 Attention-based deep learning framework, high performance potential, built-in interpretability Requires large datasets and computational power Therefore, future research should focus on multi-center, large-sample validation to improve the external validity and generalizability of the model. Additionally, extracting quantitative features from imaging omics should be prioritized to enhance the clinical relevance and application value of the model. 2. The Prospects of Machine Learning in Non-Surgical Treatment of HAE 2.1 Current Non-Surgical Treatment Methods for HAE The non-surgical treatment of HAE relies on albendazole-based medications12, which interfere with microtubule formation by binding to β-tubulin, thereby impairing nutrient absorption and parasite growth. However, albendazole does not kill the parasite and has significant hepatotoxicity. Therefore, although the medication can improve patient survival rates, its effectiveness remains limited, especially for patients who cannot undergo surgery. In such cases, prevention and continuous monitoring become crucial treatment strategies. In addition to conventional drug therapy, the development of new drugs is also an important direction for non-surgical treatment. Mefloquine12 has shown certain advantages in terms of its anti-parasitic effect and lower hepatotoxicity.Furthermore, progress has been made in vaccine development, such as the recombinant Tetraspanin 3 vaccine13 , which induces strong local and systemic immune responses, effectively protecting humans from infections of Echinococcus multilocularis in the intestine, bloodstream, and liver. However, these studies have not yet undergone large-scale clinical trials and face challenges regarding individual variations in efficacy. 2.2 The Prospects of Machine Learning in HAE Non-Surgical Treatment Through Imaging and Multi-Omics Data Machine learning also shows great potential in the non-surgical treatment of HAE. By deeply analyzing patients' imaging features and multi-omics data, machine learning can provide precise analysis in early disease diagnosis, treatment processes, and prognosis assessment. Since early symptoms of HAE are often atypical, making early detection difficult, machine learning can significantly enhance the accuracy of early intervention, treatment effectiveness, and prognosis prediction through the deep analysis of imaging features and multi-omics data. CT scans and MRI images, as the most commonly used imaging tools, help doctors make judgments by analyzing features such as lesion size and shape. Machine learning can extract characteristics such as tumor morphology, size, density, and texture, allowing it to identify potential lesions even before clear clinical symptoms appear. By analyzing features like irregular tumor borders and vascular invasion, machine learning can alert clinicians to high-risk patients without obvious symptoms, assisting in decisions about whether to proceed with surgery or opt for non-surgical treatment. Additionally, features such as cavitation and cystic changes in imaging can reflect the prognosis of the disease. In conjunction with imaging data, integrated multi-omics analysis (Table 2) can also help identify early biomarkers for HAE. Machine learning can extract features from miRNA1,lncRNAs14, transcriptomics15 and metabolomics , revealing molecular-level changes in the liver of HAE patients. The significant expression of certain miRNAs in HAE, as well as changes in the expression of liver fibrosis-related genes and immune factors, not only aid in early diagnosis but also allow for the detection of treatment responses, helping clinicians assess treatment efficacy and adjust treatment plans (Table 3). Table 2 Application Methods/Techniques Imaging Features U-Net16,SVM Surgical Decision XGBoost,LightGBM,CatBoost Multi-Omics Data SNF17,DeepProg17,FM Table 3 Application Area Traditional Methods Machine Learning Diagnosis Relies on imaging examinations and subjective judgment Automatically extracts imaging features, improving diagnostic accuracy and reducing subjective bias Surgical Decision Relies on the experience and clinical judgment of surgeons Provides objective, data-driven decision support based on extensive clinical data Personalization Lacks personalization Analyzes multi-omics and imaging data to revise treatment plans Early Diagnosis Relies on clinical symptoms Combines imaging and omics data to identify potential lesions early Summary The study by Da-Long Zhu et al. applies machine learning to surgical decision-making in HAE, providing a more objective and accurate approach to disease treatment. By using various feature selection methods and the XGBoost model, the study successfully identified key features from a large amount of clinical data. The use of SHAP analysis enhanced the model's interpretability, increasing clinicians' trust in the machine learning model. These findings play a crucial role in surgical decision-making and provide strong data support for HAE treatment decisions. By combining imaging and multi-omics analysis, machine learning can play a significant role in both surgical and non-surgical treatment of HAE. However, current research still faces challenges, such as small sample sizes and single-source data, which affect the external validity and generalizability of the model. Additionally, there is still a lack of feature extraction and in-depth analysis of imaging omics and multi-omics data. Future research should focus on multi-center, large-sample validation to further improve the model's interpretability and clinical relevance. In conclusion, machine learning demonstrates enormous potential in the surgical and non-surgical treatment of HAE. In the future, it will provide data support and objective analysis for early diagnosis, treatment effectiveness evaluation, and long-term prognosis of HAE patients. Citation 1. Boubaker, G. et al. Regulation of hepatic microRNAs in response to early stage Echinococcus multilocularis egg infection in C57BL/6 mice. PLoS Negl Trop Dis 14, e0007640 (2020). 2. Liu, H. et al. Induced hepatocyte-like cells derived from adipose-derived stem cells alleviates liver injury in mice infected with Echinococcus Multilocularis. Sci Rep 14, 26296 (2024). 3. McManus, D. P., Gray, D. J., Zhang, W. & Yang, Y. Diagnosis, treatment, and management of echinococcosis. BMJ 344, (2012). 4. Tang, T. et al. Interpretable machine learning model for predicting post-hepatectomy liver failure in hepatocellular carcinoma. Sci Rep 15, 15469 (2025). 5. Liang, D. et al. Perspective: Global Burden of Iodine Deficiency: Insights and Projections to 2050 Using XGBoost and SHAP. Adv Nutr 16, 100384 (2025). 6. Wang, Z. et al. Multiclassification of Hepatic Cystic Echinococcosis by Using Multiple Kernel Learning Framework and Ultrasound Images. Ultrasound Med Biol 50, 1034–1044 (2024). 7. Aydin, Y. et al. Relevance of Pulmonary Alveolar Echinococcosis. Arch Bronconeumol (Engl Ed) 56, 779–783 (2020). 8. Ellmann, S. et al. Tumor grade-titude: XGBoost radiomics paves the way for RCC classification. Eur J Radiol 188, 112146 (2025). 9. Yanagawa, R. et al. LightGBM outperforms other machine learning techniques in predicting graft failure after liver transplantation: Creation of a predictive model through large-scale analysis. Clin Transplant 38, e15316 (2024). 10. Han, Y. et al. Early prediction of sepsis associated encephalopathy in elderly ICU patients using machine learning models: a retrospective study based on the MIMIC-IV database. Front Cell Infect Microbiol 15, 1545979 (2025). 11. Jin, Y. et al. Classification of Alzheimer’s disease using robust TabNet neural networks on genetic data. Math Biosci Eng 20, 8358–8374 (2023). 12. Rufener, R. et al. Activity of mefloquine and mefloquine derivatives against Echinococcus multilocularis. Int J Parasitol Drugs Drug Resist 8, 331–340 (2018). 13. Dang, Z. et al. A Pilot Study on Developing Mucosal Vaccine against Alveolar Echinococcosis (AE) Using Recombinant Tetraspanin 3: Vaccine Efficacy and Immunology. PLoS Negl Trop Dis 6, e1570 (2012). 14. Nian, X. et al. Understanding pathogen–host interplay by expression profiles of lncRNA and mRNA in the liver of Echinococcus multilocularis-infected mice. PLoS Negl Trop Dis 16, e0010435 (2022). 15. Zhang, X. et al. Transcriptomic Profiling Reveals Gene Expression Changes in Mouse Liver Tissue During Alveolar Echinococcosis. Genes (Basel) 16, 839 (2025). 16. Yousef, R. et al. U-Net-Based Models towards Optimal MR Brain Image Segmentation. Diagnostics (Basel) 13, 1624 (2023). 17. Poirion, O. B., Jing, Z., Chaudhary, K., Huang, S. & Garmire, L. X. DeepProg: an ensemble of deep-learning and machine-learning models for prognosis prediction using multi-omics data. Genome Med 13, 112 (2021). "
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Zhu DL, Tulahong A, Liu C, Aierken A, Tan W, Ruze R, Yuan ZD, Yin L, Jiang TM, Lin RY, Shao YM, Aji T. Identification of key factors and explainability analysis for surgical decision-making in hepatic alveolar echinococcosis assisted by machine learning. World J Gastroenterol 2025; 31(37): 111038
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"The quality of evidence is really poor in this article. Besides, there is a real conflict of interest: the author works as a speaker ..."
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"The quality of evidence is really poor in this article. Besides, there is a real conflict of interest: the author works as a speaker for the laboratory in Mexico, and this is an ethical issue. The conclusion is not valid without the statistical analysis. The sample size is very small, and readers should not believe that sylimarine is useful in MASLD "
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Martínez-Sánchez FD, Martínez-Vázquez SE, Gutiérrez-Monterrubio R, Muñoz-Martínez S, Garcia-Juarez I. Silymarin-alpha lipoic acid and metabolic dysfunction-associated steatotic liver disease: Insights and methodological considerations. World J Hepatol 2025; 17(9): 110162
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"Great subject, it is very difficult to define when autoimmune hepatitis is refractory and when we should change therapy to a second ..."
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"Great subject, it is very difficult to define when autoimmune hepatitis is refractory and when we should change therapy to a second line. Most of the time, patients receive steroids for long periods, and that is unnecessary. It is very important to switch patients as soon as possible, instead of repeating steroid treatments for long periods, and second- and third-line options are safe and effective treatments, and hepatologists should not be afraid to use them "
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Malakar S, Shamsul Hoda U, Giri S, Samanta A, Roy A, Gupta R, Kumar SR, Agarwal M, Pawar A, Rungta S, Ghoshal UC. Difficult to treat and refractory autoimmune hepatitis: Recent advances in pharmacological management. World J Hepatol 2025; 17(9): 110264
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