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931 items Read more >>
1
"Dear Editor, We sincerely appreciate your editorial work on this article and are very satisfied with the peer review process. One ..."
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"Dear Editor, We sincerely appreciate your editorial work on this article and are very satisfied with the peer review process. One question we have is that we have not been able to find the published link to this article on PubMed, and we are unsure whether it will be indexed in PubMed. We have no other comments. "
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Chen HJ, Li J, Xu XM, Zhang B, Cheng BC, Shi J. Preterm heart failure and refractory lactic acidosis caused by congenital hypothyroidism: A case report and review of literature. World J Clin Cases 2026; 14(1): 115845
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"The editorial and peer-review process of the World Journal of Orthopedics was professional, transparent, and well structured. The ..."
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"The editorial and peer-review process of the World Journal of Orthopedics was professional, transparent, and well structured. The reviewers' comments were constructive and helped improve the scientific quality, clarity, and organization of the manuscript. Communication from the editorial office was timely and clear throughout the submission and publication process. The Journal maintains good academic standards and provides an efficient platform for disseminating orthopedic research. Overall, my experience with the journal was positive and satisfactory. "
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Rathod AP, Rathod Y, Baitule R, Pundkar G, Saodekar H. Platelet rich plasma applications in orthopedics: A review of recent advances. World J Orthop 2025; 16(12): 110377
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"I appreciate the opportunity to publish our article in this Journal . The editorial and peer-review process was professional, ..."
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"I appreciate the opportunity to publish our article in this Journal . The editorial and peer-review process was professional, constructive, and timely. The reviewers’ comments were insightful and helped improve the scientific clarity and overall quality of the manuscript. Communication from the editorial office was efficient, and the publication process was transparent. I am satisfied with the journal’s standards and would consider submitting future work to this journal. I also recommend the World Journal of Nephrology to colleagues in the field for its commitment to high-quality academic publishing. "
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Khawar MMH, Abid MH, Cheema MBA, Khawar M, Shaukat M, Khan MHA, Saifullah M, Noureen R, Khail HA, Qureshi AA, Khokhar MA. Clinicopathological predictors of right para esophageal lymph node metastasis in papillary thyroid carcinoma: A systematic review and meta-analysis. World J Clin Oncol 2025; 16(11): 110792
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"I appreciate the opportunity to publish our article in the World Journal of Nephrology. The editorial and peer-review process was ..."
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"I appreciate the opportunity to publish our article in the World Journal of Nephrology. The editorial and peer-review process was professional, constructive, and timely. The reviewers’ comments were insightful and helped improve the scientific clarity and overall quality of the manuscript. Communication from the editorial office was efficient, and the publication process was transparent. I am satisfied with the journal’s standards and would consider submitting future work to this journal. I also recommend the World Journal of Nephrology to colleagues in the field for its commitment to high-quality academic publishing. "
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Khawar M, Sehar A, Shahzad M, Farooq H, Rehman OU, Alvi Z, Ali S, Hadeed Khawar MM, Saifullah M, Khail HA, Qadeer A, Villanueva MN, Mour GK. Risk factors for developing acute kidney injury after heart transplant: A systematic review and meta-analysis. World J Nephrol 2025; 14(4): 110791
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"Thank you very much for informing me that our manuscript, has been accepted for publication. We sincerely appreciate the time and ..."
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"Thank you very much for informing me that our manuscript, has been accepted for publication. We sincerely appreciate the time and effort of the editors and reviewers for their valuable feedback and constructive suggestions. We are honored by this opportunity and grateful for your support throughout the review process. Please let us know if any further actions or documents are required from our side at this stage. "
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Li GQ, Zhang J, Huang Y. Factors associated with aseptic loosening after primary total hip arthroplasty: A systematic review and meta-analysis. World J Orthop 2026; 17(1): 114482
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"The review process was excellent and well organized. The reviewers provided clear, detailed, and constructive feedback, which made ..."
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"The review process was excellent and well organized. The reviewers provided clear, detailed, and constructive feedback, which made it easy to understand and implement the required revisions. After resubmission, the re-review was completed promptly without unnecessary delays. Overall, the experience was smooth, efficient, and highly satisfactory, reflecting a professional and author friendly review system. "
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Desouza C, Siddique I, Kushwaha K, Puri A. Outcomes of reverse vs anatomic total shoulder arthroplasty in glenohumeral osteoarthritis without rotator cuff deficiency: A meta-analysis. World J Orthop 2026; 17(1): 110188
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"Dear Editorial Team, World Journal of Orthopaedics(WJO) I am writing to provide my feedback regarding the recent publication of my ..."
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"Dear Editorial Team, World Journal of Orthopaedics(WJO) I am writing to provide my feedback regarding the recent publication of my article title " Comparison of two fixation techniques of olecranon osteotomy after reconstruction of intra-articular distal humerus fractures ". Manuscript NO: 111460 I would like to express my complete satisfaction with the entire process The peer review process of World Journal of Orthopaedics(WJO) was exceptionally efficient and transparent. I particularly appreciated the Relativities-of-References-to-Subject-of-Manuscript and Audio Core Tip. The speed of the review did not compromise the quality of the feedback; the reviewers' insights were constructive and significantly strengthened the final manuscript. The unique assessment criteria used by the journal provided a fresh and comprehensive perspective on my research. The transition from acceptance to online publication was seamless and impressively fast. The editorial team maintained excellent communication throughout the process. I am thoroughly impressed with the journal’s innovative approach to scholarly publishing. I will certainly recommend this journal to my colleagues and look forward to submitting my future work here. The professionalism of the editorial staff and the efficiency of the online publication phase exceeded my expectations. Thank you for a smooth and rewarding experience. I look forward to working with your journal again in the future. Best regards, Dr. Faaiz Ali Shah Associate Professor Orthopaedics Lady Reading Hospital Peshawar Pakistan "
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Shah FA, Sattar A, Iqbal J. Comparison of two fixation techniques of olecranon osteotomy after reconstruction of intra-articular distal humerus fractures. World J Orthop 2025; 16(12): 111460
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"Overall, the process is fair, transparent, and of high quality. However, as previously communicated, requesting a second round of ..."
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"Overall, the process is fair, transparent, and of high quality. However, as previously communicated, requesting a second round of edits is not entirely fair and may place unnecessary burden on the authors. It would be more reasonable to allow a single, final submission of revisions at the end of the process. Aside from this concern, the workflow is well organized, efficient, and easy to navigate, reflecting a generally smooth and professional experience for contributors. "
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Khalil MAM, Sadagah NM, Mahmood HHK, Altom AA, Tan J, Al-Qurashi SH. Donor-derived cell-free DNA and its utility in kidney transplantation: A myth or a reality. World J Nephrol 2025; 14(4): 109099
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"Overall, the process is fair, transparent, and of high quality. However, as previously communicated, requesting a second round of ..."
[Read more]
"Overall, the process is fair, transparent, and of high quality. However, as previously communicated, requesting a second round of edits is not entirely fair and may place unnecessary burden on the authors. It would be more reasonable to allow a single, final submission of revisions at the end of the process. Aside from this concern, the workflow is well organized, efficient, and easy to navigate, reflecting a generally smooth and professional experience for contributors. "
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Al-Qurashi SH, Khalil MAM, Mahmood HHK, A Al-Ghamdi R, Alsharif MM, Said Ahmed MA, Alghamdi RMH, Sadagah NM. Predictors of non-diabetic kidney disease in diabetics: A Saudi Arabian perspective. World J Nephrol 2025; 14(4): 111613
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"The peer-review and publication process for this manuscript was conducted in a timely, transparent, and professional manner. The ..."
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"The peer-review and publication process for this manuscript was conducted in a timely, transparent, and professional manner. The reviewers’ comments were constructive and helped improve the scientific clarity and clinical relevance of the article. Communication from the editorial office was clear and efficient throughout the review and production stages. We appreciate the editorial team’s efforts in facilitating a smooth and rigorous publication process. "
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Pal P, Kata P, Mateen MA, Gupta R, Tandan M, Duvvur NR. Intestinal ultrasound for monitoring postoperative Crohn’s disease: A systematic review and clinical implications. World J Gastrointest Surg 2025; 17(12): 111481
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"The journal was efficient in their peer-review and publication of the article although required many formatting changes to the ..."
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"The journal was efficient in their peer-review and publication of the article although required many formatting changes to the manuscript before publication. They were easy to work with. The peer-reviewer gave quite helpful feedback that strengthened the final publication. Overall, the journal was respectful in their interactions with the authors and their peer-review process was both rapid and thorough. "
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Vlasak A, Orear C, Sakryd G, Metzl J. Achilles, peroneus longus and brevis ruptures with lateral malleolus fracture: A case report and review of literature. World J Orthop 2026; 17(1): 112222
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"Thanks for the effort. I believe that shortening the publication period would be of great help. The process of completing teh online ..."
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"Thanks for the effort. I believe that shortening the publication period would be of great help. The process of completing teh online publishing is a little bit lengthy. However, this was a great opportunity to publish my article in such a prestigious journal. All other aspects of the manuscript handling and peer review were just fine and fair. "
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Khalifa AA, Moustafa M, Lemma S, Fayez M, Abdelaal AM, Fadle AA. Coronal plane alignment of the knee phenotypes and ankle joint coronal plane alignment patterns in Egyptian population. World J Orthop 2026; 17(1): 111824
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"It was a very quick and efficient editorial process. It was sometimes difficult to actually contact the publisher in a timely manner ..."
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"It was a very quick and efficient editorial process. It was sometimes difficult to actually contact the publisher in a timely manner for questions, but in retrospect we were able to figure things out on the online process. One initial problem was that the correspondence kept coming to the junk mail folder of the institution, but we quickly realized that. Overall I was satisfied with the process. "
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Georgiadis GM, Arefi IA, Drees SM, Nair A, Wagner D, Lawrence AC. Cephalomedullary fusion nails for treatment of infected stemmed revision total knee arthroplasty: Four case reports. World J Orthop 2026; 17(1): 114078
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"Dear Editor, Editorial Team and Reviewers of the Journal I would like to express my sincere gratitude for the excellent work of your ..."
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"Dear Editor, Editorial Team and Reviewers of the Journal I would like to express my sincere gratitude for the excellent work of your magazine. I have been your regular contributor for several years now, and it gives me real pleasure to work on each article in the issue. Your team has done an outstanding job of building the database. The review process and post-production are well-developed and balanced. The editorial staff of the journal is very positive towards the authors and helps in solving any issues. The speed of acceptance of articles after passing all the stages of peer review is impressive. The design of the articles is visually appealing, the writing style is professional and very pleasant. Your journal has become an integral part of my daily scientific work, and I hope for further invitations. For our part, my co-authors and I are ready to submit new articles. Thank you for your support of the authors. With best wishes, Mikhail Kostik, MD, Ph.D., Professor "
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Petukhova VV, Mushkin AY, Maletin AS, Dogonadze MZ, Zabolotnykh NV, Dyakova ME, Esmedlyaeva DS, Vinogradova TI, Kostik MM. Novel use of bisphosphonates to improve surgical outcomes in experimental bone tuberculosis. World J Orthop 2026; 17(1): 112262
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"The peer review process was efficient and well structured, allowing for timely and constructive academic exchange. The reviewers ..."
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"The peer review process was efficient and well structured, allowing for timely and constructive academic exchange. The reviewers provided thoughtful, professional, and helpful comments that significantly contributed to improving the scientific quality, clarity, and overall presentation of our manuscript. We sincerely appreciate the reviewers’ and editors’ time, effort, and dedication throughout the evaluation process. "
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Deng DW, Leng AX, He Q, Zhou CG. Nomogram for prediction of six-month mortality following endovascular treatment of delayed post-pancreatectomy hemorrhage. World J Gastrointest Surg 2025; 17(12): 113029
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"A very good and rigorous peer review process. We would be glad to submit more articles to this great journal. I would be glad if this ..."
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"A very good and rigorous peer review process. We would be glad to submit more articles to this great journal. I would be glad if this journal secures a Thomson Reuters impact factor as the journal only have Scimago for now. Please try very hard to secure a JCR impact factor. "
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Chinawa JM, Adiele DK, Chinawa AT, Ossai EN, Onyia JT, Onukwuli VO, Chime PU. Relationships among depression, anxiety and suicidal ideation in parents of children with congenital heart defects: A dynamic triad. World J Psychiatry 2026; 16(1): 114555
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"I am satisfied with all the editorial process. All steps of the editorial process have been done in a very satisfactory way. Perhaps ..."
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"I am satisfied with all the editorial process. All steps of the editorial process have been done in a very satisfactory way. Perhaps the time period between submission of the paper and its publication should be shorter. I think that the Reviewers should be paid in order to encourage them to be faster in their evaluations. It is ridiculuous that the authors must pay for publication of their articles and that the Reviewers have to make their evaluations for free. "
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Rodriguez-Merchan EC. When performing a total hip arthroplasty, it is essential to correct any pre-existing leg-length discrepancy during surgery. World J Orthop 2026; 17(1): 113277
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"I had an outstanding editorial and publishing experience with the World Journal of Gastroenterology. From submission through ..."
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"I had an outstanding editorial and publishing experience with the World Journal of Gastroenterology. From submission through publication, the editorial team demonstrated professionalism and efficiency at every stage. The online submission platform was intuitive and streamlined, allowing seamless manuscript tracking and timely updates. The peer review process was rigorous and constructive, with insightful feedback that significantly strengthened the manuscript. The editorial team meticulously polished the final draft, ensuring it met the journal’s high standards. The published article was well-formatted, visually clear, and reader-friendly—including all figures and tables. I was particularly impressed by the journal’s strong commitment to academic integrity, upheld through proactive measures to detect and prevent misconduct. The publication timeline was reasonable, and the editorial staff remained consistently responsive and supportive throughout. I highly recommend the World Journal of Gastroenterology to fellow researchers for its dedication to academic excellence and its author-centered approach. "
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Zhang JW. Systemic inflammatory markers in gastric ulcer: Leveraging routine blood tests. World J Gastroenterol 2026; 32(1): 114172
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"The submission system is intuitively designed, making the entire upload process smooth and hassle-free without complex operations. ..."
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"The submission system is intuitively designed, making the entire upload process smooth and hassle-free without complex operations. The review workflow is highly transparent and clear, with timely updates on each stage that keep authors well-informed. Notably, the review efficiency is impressive, with the process progressing much faster than many comparable journals. The peer review is objective and impartial, as reviewers provide insightful and constructive comments based on rigorous academic standards. These valuable suggestions have significantly helped refine our manuscripts’ scientific rigor and presentation quality. We highly appreciate the journal’s commitment to maintaining high-quality review standards and would strongly recommend it to fellow researchers. "
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Xu S, Lu GR. Potential of lysine succinylation as a therapeutic target for gallstone formation: An insightful strategy. World J Gastroenterol 2026; 32(1): 114865
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"Once again, I express my sincere gratitude for the efforts of your magazine and its editors 。I sincerely appreciate the exceptionally ..."
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"Once again, I express my sincere gratitude for the efforts of your magazine and its editors 。I sincerely appreciate the exceptionally high professional and technical level as well as the rigorous scientific attitude of your magazine.I am looking forward to the continuation of our cooperation in the future and the publication of more high - quality articles. "
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Chen Z, Shi J, Sun H, Zhang XQ. Clinical evaluation of bare metal stent-assisted endovascular repair in upper extremity arterial trauma. World J Cardiol 2025; 17(12): 107338
20429 items Read more >>
1
"In this manuscript, the authors performed a meta-analysis of 30 randomized controlled trials involving 16,977 patients to assess ..."
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"In this manuscript, the authors performed a meta-analysis of 30 randomized controlled trials involving 16,977 patients to assess whether rectal administration of indomethacin prevents post–endoscopic retrograde cholangiopancreatography pancreatitis (PEP).
The results show no statistically significant difference in the risk of PEP between patients who received indomethacin and those who did not. Nevertheless, in the Discussion and Conclusion, the authors present their findings in a way that implies a beneficial effect of rectal indomethacin for PEP prevention.
This clear discrepancy between the reported results and the authors’ interpretation renders the manuscript confusing and undermines the validity of its conclusions."
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Tian F, Huang ZC, Khizar H, Qiu K. Efficacy of indomethacin for the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis: A comprehensive meta-analysis of randomized controlled trials. World J Gastroenterol 2026; 32(1): 113232
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"The review clearly articulated why smoking cessation is particularly critical in diabetes, linking smoking to increased complications ..."
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"The review clearly articulated why smoking cessation is particularly critical in diabetes, linking smoking to increased complications and mortality. Authors emphasized routine integration into diabetes care is a major practical strength. Physiological (weight gain, insulin sensitivity changes) and psychological barriers were appropriately highlighted, and the need for tailored approaches is reinforced. This framing helps justify why standard cessation models may be insufficient for this population. The identification of varenicline as the agent with the strongest evidence in people with diabetes is appropriate and clinically useful. The cautious tone regarding nicotine replacement therapy and bupropion was justified because of limited diabetes-specific data. Inclusion of harm reduction strategies, GLP-1 receptor agonists, and digital tools reflects contemporary practice and emerging research directions. The call for pragmatic trials and long-term strategies is well aligned with current gaps in evidence.
However, the role of GLP-1 receptor agonists is interesting but somewhat speculative. Explicitly acknowledging that evidence for a direct effect on smoking cessation is indirect or preliminary would improve scientific rigor.
"
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Russo C, Walicka M, Cohen G, Bellanca CM, Geraci G, Caponnetto P, Noviello DE, Chianetta R, George J, Sammut R, Franek E, Polosa R. Addressing the dual challenge: Managing smoking cessation in patients with diabetes. World J Diabetes 2025; 16(12): 105241
3
"Dear colleagues!
I read with interest your manuscript Artificial intelligence in functional gastrointestinal disorders: From precision ..."
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"Dear colleagues!
I read with interest your manuscript Artificial intelligence in functional gastrointestinal disorders: From precision diagnosis to preventive healthcare, published in Artif Intell Gastroenterol 2026; 7(1): 112357. The topic is really actual and in your paper, you addressed important aspects of implementation of artificial intelligence to this specific field.
For sure, FGIDs have common pathogenetic features; however, the overlap in the underling mechanisms between each of the disorders relatively low. This makes development of the integrative algorithms for diagnosis, differentiation and treatment (especially personalized) difficult. And this highlights the complexity of your task - to cover all these aspects in one mini-review. I hope that you will continue your work. Given the complexity of integrative coverage of all aspects of AI application in functional diseases of the gastrointestinal tract, perhaps you can prepare separate, more specific materials for each of the diseases. I believe that such material would also be of interest to the readers."
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Yan YN, Zeng JQ, Ding X. Artificial intelligence in functional gastrointestinal disorders: From precision diagnosis to preventive healthcare. Artif Intell Gastroenterol 2026; 7(1): 112357
4
"• Pringle is an important technique in lap liver surgery, but if a patient has previously undergone gallbladder removal or gastric ..."
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"• Pringle is an important technique in lap liver surgery, but if a patient has previously undergone gallbladder removal or gastric surgery, strong adhesions can make it difficult to reach the hepatoduodenal ligament. However, the authors' method of using the ligamentum teres hepatis seems to be a good technique. It has been mentioned that there have been cases where the IVC or right renal vein has been damaged when the technique was inexperienced. Please explain this. Also, please explain what efforts are being made to prevent intestinal adhesions to the hepatoduodenal ligament in the future.
•
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Kawano Y, Murokawa T, Aoki Y, Hamaguchi A, Ono T, Haruna T, Yoshimori D, Irie T, Ueda J, Shimizu T, Matsushita A, Kawashima M, Ga R, Furuki H, Kanda T, Oshiro Y, Minamimura K, Yoshioka M, Taniai N, Nakamura Y, Yoshida H. Utility of liver surface-guided encirclement of hepatoduodenal ligament for the Pringle maneuver in minimally invasive repeat liver resection. World J Gastroenterol 2026; 32(1): 113470
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"Congratulations on the publication of your paper. I read it promptly and found it extremely interesting. The quality of the manuscript ..."
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"Congratulations on the publication of your paper. I read it promptly and found it extremely interesting. The quality of the manuscript is very high, and it incorporates novel findings, making it a highly valuable contribution. For these reasons, I would like to award it first prize without any reservation. It has been a long time since I last encountered such an outstanding paper. It is truly impressive that you have produced so many publications to date. I sincerely encourage you to continue your efforts in writing papers for the advancement of medicine, and I wish you continued success in your career. Thank you very much."
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Usuda D, Furukawa D, Imaizumi R, Ono R, Kaneoka Y, Nakajima E, Kato M, Sugawara Y, Shimizu R, Inami T, Kawai K, Matsubara S, Tanaka R, Suzuki M, Shimozawa S, Hotchi Y, Osugi I, Katou R, Ito S, Mishima K, Kondo A, Mizuno K, Takami H, Komatsu T, Nomura T, Sugita M. Spontaneous bacterial peritonitis due to Edwardsiella tarda in an immuno-compromised dialysis patient: A case report and review of literature. World J Clin Cases 2026; 14(1): 115102
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"This meta-analysis found that rectal indomethacin did not differ significantly from placebo in PEP incidence. However, the ..."
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"This meta-analysis found that rectal indomethacin did not differ significantly from placebo in PEP incidence. However, the pharmacological safety profile was very satisfactory with no significant increase in adverse events compared with the control group. The evidence was more substantial in high-risk patients. It is known that, given this satisfactory safety profile, many centers administer NSAIDs rectally. The authors conclude with the recommendation that “Rectal indomethacin appears to be safe and may offer benefit in selected high-risk patients, though findings should be interpreted with caution due to high heterogeneity”.
The meta-analysis's obvious conclusion is that the drug is ineffective when administered before ERCP. However, in an attempt to mitigate the effects, the authors agree to “accept the results with caution.”
PEP is known to be the most common serious complication of ERCP, occurring in approximately 3.5% to 15% of cases, and up to 25% in high-risk groups. According to the latest clinical guidelines (including ASGE 2023 and IAP 2025 updates), a multi-modal approach is the standard of care. Prevention strategies are divided into patient selection, pharmacological prophylaxis, and procedural techniques. The Summary Protocol for 2026 recommends the following: For Universal Prophylaxis, Rectal Indomethacin 100 mg for all patients + moderate hydration, and for High-Risk Prophylaxis: Rectal NSAIDs + Aggressive Lactated Ringer's + Prophylactic PD Stent.
I think that such vital clinical issues are best resolved through international consensus, which will provide clear, universally accepted guidelines."
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Tian F, Huang ZC, Khizar H, Qiu K. Efficacy of indomethacin for the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis: A comprehensive meta-analysis of randomized controlled trials. World J Gastroenterol 2026; 32(1): 113232
7
"I would like to commend the authors for an exceptionally comprehensive and timely review on strategies to optimize mesenchymal stem ..."
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"I would like to commend the authors for an exceptionally comprehensive and timely review on strategies to optimize mesenchymal stem cell (MSC) therapy for tendon-bone healing. I found the sections on MSC-derived extracellular vesicles (EVs)/exosomes particularly insightful. The manuscript effectively highlights the advantages of EV-based, cell-free therapies, including lower immunogenicity, reduced tumorigenic risk, and the ability to mediate paracrine effects similar to parent MSCs, positioning them as a promising modality for tendon-bone regeneration.
The discussion of strategies to enhance EV efficacy, such as preconditioning of parent MSCs (hypoxia, LIPUS, magnetic stimulation, and pharmacological agents) and engineering delivery platforms (endogenous/exogenous loading, surface modifications for targeted delivery), is highly relevant for translational applications. I especially appreciated the emphasis on exosome-mediated modulation of macrophage polarization, promotion of angiogenesis, and enhancement of osteogenic and chondrogenic differentiation, which highlights their mechanistic versatility.
While the manuscript provides excellent mechanistic insight and preclinical evidence, a brief discussion on challenges in EV translation—such as scalable production, stability, standardization of dosing, and regulatory considerations—could further strengthen the practical relevance. Nonetheless, this focused review of MSC-derived EVs significantly contributes to the field by showcasing both the potential and current hurdles of cell-free therapies for tendon-bone healing."
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Li H, Li ZP, Zhu MT, Lan CH, Wang YX, Liao P, Chen Z, Wang P, Sun JK, Shi Z, Lu PY, Lou C, Xu GH. Optimizing mesenchymal stem cell therapy for tendon-bone healing: Multifaceted approaches and future directions. World J Stem Cells 2025; 17(12): 114076
8
"The ethical approval provided by the author meet the requirements.
This report provided a rare case report, with educational ..."
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"The ethical approval provided by the author meet the requirements.
This report provided a rare case report, with educational significance.
Of “It is a safe and reliable approach for OT treatment, which
offers the advantages of minimal trauma, mild postoperative pain, and rapid recovery for stylistic precision”. It’s not adequate in this section.
Of “Abdominal contrast-enhanced CT plays a crucial role in diagnosing OT, and laparoscopic surgery is a safe and effective diagnostic and therapeutic approach” in the conclusion. It’s not adequate to address “and laparoscopic surgery is a safe and effective diagnostic and therapeutic approach” in the “Conclusion”.
Structure of relative description was not adequate. Discussion needs not involve much about other aspects of omental torsion other than imaging diagnosis, it should focus on imaging diagnosis and differential diagnosis, especially contrast-enhanced CT and contrast-enhanced ultrasound. Compared to CT, contrast-enhanced CT has higher sensitivity and specificity in the visualization of the omental vascular running and contrast perfusion, and has better ability to determine whether there is ischemia and associate secondary change.
“whirlpool sign” is unique for the diagnosis of omental torsion.
Duplex ultrasound can find “whirlpool sign” and loss of color signal of vascualrity in some cases of omental torsion. It should be addressed that color Doppler flow imaging is usually not able to detect blood vessels in the great omentum. Contrast-enhanced ultrasound can find defect of vascular perfusion in the region of the great omentum with necrosis, while there was discussion on this technique.
It should be addressed that “whirlpool sign” can only be detected in part cases of omental torsion.
Ovary torsion has “whirlpool sign” and abdominal emergency, and differential diagnosis is required.
The report was written in English awkwardly, not meeting native English and standardized professional expression.
Of Figure 1. There were no arrows to indicate “whirlpool sign” of omental torsion.
Of “(hematoxylin and eosin, × 50)” in Figure 4. “× 50” does not follow routine practice, and it may be mistaken.
"
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Li YL, Fan JX, Yang Y, Yao MQ, Jiang YP. Omental torsion diagnosed by abdominal contrast-enhanced computed tomography: A case report. World J Radiol 2025; 17(12): 114398
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"This is very interesting paper about the relationship between IBD and Alzheimer’s. Recent studies suggest that patients with IBD ( ..."
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"This is very interesting paper about the relationship between IBD and Alzheimer’s. Recent studies suggest that patients with IBD ( UC and chronic ) have a significantly higher about 2.5 times risk of developing dementia,including Alzheimer’s disease and are diagnosed at a younger age. This association may be due to the intestinal inflammation caused by IBD, disruption of intestinal flora and dysfunction of the gut-brain axis sharing a common pathway with the underlying mechanisms of Alzheimer’s disease (such as amyloid beta accumulation),and it is possible that improving the intestinal environment may lead to the prevention of dementia."
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Durairajan SSK, Singh AK, Sulaiman SM, Patnaik S, Krishnamoorthi S, Iyaswamy A, Vellingiri B, Yang CB, Williams LL. Molecular links between inflammatory bowel disease and Alzheimer’s disease through immune signaling and inflammatory pathways. World J Gastroenterol 2025; 31(48): 111301
10
"Bouveret syndrome is a rare form of gallstone ileus, presenting as gastric outlet obstruction due to a large gallstone that has ..."
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"Bouveret syndrome is a rare form of gallstone ileus, presenting as gastric outlet obstruction due to a large gallstone that has migrated through a biliogastric or bilioduodenal fistula.This manuscript is a well-written and presented rarely case report.Bouveret Syndrome primarily affects elderly patients. The authors point out that it may also occur in young individuals. I think that this manuscript is worth to publication."
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Hu YC, Chen XY, Cao MK, Fan Z. Bouveret syndrome in a young patient: A case report and review of literature. World J Gastrointest Surg 2025; 17(12): 113532
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"This study clearly highlights the importance and contribution of AI in the diagnosis of rectal neuroendocrine tumors in daily clinical ..."
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"This study clearly highlights the importance and contribution of AI in the diagnosis of rectal neuroendocrine tumors in daily clinical practice. It is known that rectal endocrine tumors present significant diagnostic difficulties because they are often considered as hyperplastic polyps and are either not removed and therefore not subjected to histological evaluation, or are removed as normal polyps. The consequence is that diagnosis is delayed or requires subsequent complementary imaging and/or endoscopic examination.
The authors developed an image analysis and detection model for rectal neuroendocrine tumors using the YOLOv7 algorithm. This algorithm demonstrated significant diagnostic accuracy, exceeding that of most endoscopes with which it was compared.
It has been repeatedly emphasized that AI is expected to revolutionize the diagnosis of many gastrointestinal diseases, including rectal endocrine tumors. We experience this to a large extent in daily clinical practice. However, it should be emphasized that the effectiveness of this system in detecting neuroendocrine rectal tumors should be investigated and evaluated in future large, multicenter studies."
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Liu K, Wang ZY, Yi LZ, Li F, He SH, Zhang XG, Lai CX, Li ZJ, Qiu L, Zhang RY, Wu W, Lin Y, Yang H, Liu GM, Guan QS, Zhao ZF, Cheng LM, Dai J, Bai Y, Xie F, Zhang MN, Chen SZ, Zhong XF. Artificial intelligence-assisted diagnosis of rectal neuroendocrine tumors during white-light endoscopy. World J Gastroenterol 2025; 31(48): 112683
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"1. The authors have projected the cardiotoxicity as a sequel of chemotherapy relevant to LMIC in perspective, documenting the follow ..."
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"1. The authors have projected the cardiotoxicity as a sequel of chemotherapy relevant to LMIC in perspective, documenting the follow up timings
2. The importance of the follow up and its necessity is also well brought out in the light of current literature
3. The relevance of cardiotoxicity lies in the drug / regime and the dosage. Especially if the patient was administered more than the expected maximal dosage. This can be included for better understanding. "
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Ali W, Mehmood A, Surani S. Chemotherapy-related cardiotoxicity: Bridging the gap between evidence and practice. World J Clin Cases 2025; 13(36): 114228
13
"1. The difference of a squamous cell ca in a viscera, in comparison to that in the superficial skin site can be brought out in terms ..."
[Read more]
"1. The difference of a squamous cell ca in a viscera, in comparison to that in the superficial skin site can be brought out in terms of presentation, prognosis / management / tumor behaviour, etc
2. When to suspect a similar lesion can be highlighted for the benefit of readers
3. The conclusion section can avoid summary of the manuscript, rather can include a crisp take home message on the index case."
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Li QQ, Wei J, Fang LY, Zhou JL, Zhao HF. Primary ileal squamous cell carcinoma: A case report and review of literature. World J Clin Cases 2025; 13(36): 111835
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"The article entitled Evolving trends in hepatitis A epidemiology: Shifting patterns, emerging risks, and future strategies is well ..."
[Read more]
"The article entitled Evolving trends in hepatitis A epidemiology: Shifting patterns, emerging risks, and future strategies is well written article but some comments to be considered:
- Most of the studies included in the review article depend on seroprevalence of the disease that is mean it depend on detection of antibodies which of course of low speceficity as diagnosis of HAV infection must depend on isolation of the virus by real time PCR especially in endemic areas to avoid false positive results.
- There is some redunduncy and reptition of the data (e.g Endemicity in the era of vaccination and improving living standards -- Changing epidemiology of hepatitis A
"
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Majeed AA, Sarfraz M, Butt AS. Evolving trends in hepatitis A epidemiology: Shifting patterns, emerging risks, and future strategies. World J Virol 2025; 14(4): 112590
15
" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..."
[Read more]
" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Huang K. Influence of obesity on the patient’s recovery after laparoscopic surgery. World J Clin Cases 2025; 13(36): 115269
16
" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..."
[Read more]
" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Taha R, Elsayed G, Mohamed L, Gadour E. Beyond biliary causes, fish bone perforation as a rare etiology of recurrent fever in a post-Whipple patient: A case report. World J Clin Cases 2025; 13(36): 114956
17
" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..."
[Read more]
" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Li QQ, Wei J, Fang LY, Zhou JL, Zhao HF. Primary ileal squamous cell carcinoma: A case report and review of literature. World J Clin Cases 2025; 13(36): 111835
18
"In this study, the authors describe a patient with severe ulcerative colitis resistant to treatment and comorbid health problems who ..."
[Read more]
"In this study, the authors describe a patient with severe ulcerative colitis resistant to treatment and comorbid health problems who responded favorably and without side effects to the combined treatment of an α4β7 integrin antagonist (vedolizumab) and an interleukin 23p19 inhibitor (mirikizumab).
This case reinforces the view, expressed over the last few years, of the need to combine two biological agents in treatment-resistant inflammatory bowel disease and in treatment-resistant patients with extraintestinal manifestations.
Personally, I believe we will be led to adopt the above recommendation in the near future. What remains is the approval and adoption of this recommendation by the pharmaceutical companies manufacturing biological agents, so they can conduct extensive, multicenter studies and avoid being limited to descriptions of individual cases or series from specialized centers with very small patient numbers."
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Guimarães AC, Ferreiro-Iglesias R, Calviño-Suarez C, Baston-Rey I, Barreiro-de Acosta M. Dual biologic therapy in patient with refractory ulcerative colitis and comorbidities: A case report. World J Gastroenterol 2025; 31(47): 113381
19
"1 Ethics: Does the ethical approval form provided by the author meet the requirements?
Not applicable.
2 Methods: Is the ..."
[Read more]
"1 Ethics: Does the ethical approval form provided by the author meet the requirements?
Not applicable.
2 Methods: Is the experimental method effective? Can it be repeated by fellow researchers (according to adequate textual/citation content presented)?
Not applicable.
3 Results: Are the results true and authentic? Is the theory or hypothesis of universal significance validated or partially validated?
Not applicable.
4 Figures and tables: Does the author provide perfect tables, line charts and/or graphs? Or, does the author provide figures and tables that are confusing, poorly constructed and/or not well-annotated?
Yes.
5 Biostatistics: Does the author provide perfect biostatistics data? Or, does the author provide tables and line charts that have mistakes in the data?
Not applicable.
6 References: Does the author scientifically and reasonably cite the latest references which are important in this field and related to the scientific problems and research hypotheses addressed in the study? Or, does the author self-cite, omit, mis-cite and/or over-cite references?
Yes.
7 Language: Does the language in article correctly, clearly and concisely express the information? Or, does the article have multiple grammatical and spelling mistakes?
Yes.
8 Caveats or drawbacks: What are the caveats or drawbacks for the results?
They didn't provide many new ideas."
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Li H, Li ZP, Zhu MT, Lan CH, Wang YX, Liao P, Chen Z, Wang P, Sun JK, Shi Z, Lu PY, Lou C, Xu GH. Optimizing mesenchymal stem cell therapy for tendon-bone healing: Multifaceted approaches and future directions. World J Stem Cells 2025; 17(12): 114076
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"These findings illuminate the pivotal role of YY1 in driving the progression of Helicobacter pylori-induced gastric carcinogenesis ..."
[Read more]
"These findings illuminate the pivotal role of YY1 in driving the progression of Helicobacter pylori-induced gastric carcinogenesis through the activation of epithelial-mesenchymal transition (EMT). From a molecular vantage point, this study stands as a compelling testament to rigorous scientific inquiry, underpinned by a wealth of robust experimental evidence that substantiates its central claims.
Here I only offer a suggestion and reference. In fact, cancer is a complex pathological ecosystem rather than a simple genetic disease. However, the current mainstream research perspective is greatly influenced by the "somatic mutation" theory, often believing that genes and molecules are the ultimate essence of cancer. However, such a linear reductionist view has not brought about fundamental improvements in prognosis in clinical practice, such as in targeted therapy. I believe that in the post-genomic era, we should think more about the occurrence and development of cancer from the perspectives of ecology and evolution rather than being confined to the molecular level. As I pointed out in the "Rethinking Cancer" column for the 110th anniversary of the Chinese Medical Association (https://pubmed.ncbi.nlm.nih.gov/40443342/), the key to understanding such a complex systemic disease as tumors does not lie in the relentless pursuit of genes and molecules. It can be said that the role and function (promoting or inhibiting cancer, driver, passenger or neutral) of a single gene mutation in cancer cells depend on the environment and ecological niche in which they are located. By the way, I kindly recommend the authors and your team explore the book "Rethinking Cancer" (Strauss B. et al., 2021), which is also available in Chinese version (2024, Tsinghua University Press). This book might offer a refreshing and insightful perspective on human cancers, which could help guide future research and practice and better assist in improving patient prognosis."
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Chen JW, Ouyang JJ, Wang ZH, Ma DM, Zhang Z, Teng Q, Yu G, Li XY. Yin Yang 1 activates JAK-STAT3-mediated epithelial-mesenchymal transition in Helicobacter pylori-induced gastric cancer progression. World J Clin Oncol 2025; 16(12): 112626
15899 items Read more >>
Peer-Reviewers and Manuscript Statistics
- Editorial board members
- 2264
- Peer-reviewers
- 35596
- Manuscripts received today
- 13
- Manuscript reviews today
- 30
- Unhandled manuscripts today
- 150
- Active peer-reviewers today
- 2999
- Reviewer acceptance today
- 75
- Reviewer refusals today
- 74
- Total accepted manuscripts
- 39524
- Total rejected manuscripts
- 44267
- Total peer-reviewers
- 4635953
- Total submissions
- 37446
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1
"This paper presents a systematic retrospective analysis of the incidence and clinical significance of gallstones and gallbladder wall ..."
[Read more]
"This paper presents a systematic retrospective analysis of the incidence and clinical significance of gallstones and gallbladder wall thickening in patients with liver cirrhosis, offering valuable clinical observations for practitioners. The study clearly indicates that the prevalence of gallbladder abnormalities—including gallstones and asymptomatic wall thickening—is significantly higher in patients with cirrhosis, especially in the decompensated stage, compared to the general population. This finding aligns with previous research and further supports the pivotal role of portal hypertension and hepatic dysfunction in the development of gallbladder pathology. Notably, the authors emphasize that these imaging findings are often related to cirrhosis itself rather than being indicators of acute cholecystitis. This distinction is clinically important, as it can help prevent unnecessary interventions—such as misdiagnosis and surgery for presumed acute cholecystitis—particularly in asymptomatic individuals. Moreover, the study suggests that gallbladder abnormalities correlate more strongly with the decompensated state of cirrhosis than with its etiology, providing a fresh perspective on the mechanisms underlying gallbladder changes in these patients. However, several limitations should be acknowledged. First, the retrospective design and single-center sample may limit the generalizability of the results. Second, the study lacks in-depth analysis of subgroups based on the etiology of cirrhosis, leaving it unclear whether findings differ notably in non-alcoholic liver disease patients. Finally, potential influencing factors such as gallbladder motility and medication use were not systematically evaluated, even though they may contribute to wall thickening and stone formation. Overall, this paper offers practical clinical insights into the imaging assessment of the gallbladder in cirrhotic patients. Future prospective, multicenter studies incorporating more pathophysiological parameters—such as gallbladder motility and bile composition—could help further elucidate the complex relationship between cirrhosis and gallbladder disorders and contribute to optimized clinical decision-making. "
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Tsankof A, Protopapas AA, Kyritsi V, Gogou C, Kyziroglou M, Papathanasiou E, Chatzikosma C, Michalopoulos A, Savopoulos C, Protopapas AN. Gallstones and gallbladder wall thickening in patients with cirrhosis: Prevalence and clinical impact. World J Clin Cases 2026; 14(1): 114043
2
"This meta-analysis systematically retrieved and synthesized evidence from 30 randomized controlled trials (RCTs) involving nearly ..."
[Read more]
"This meta-analysis systematically retrieved and synthesized evidence from 30 randomized controlled trials (RCTs) involving nearly 17,000 patients, providing the most comprehensive assessment to date on the efficacy of indomethacin for preventing post-ERCP pancreatitis (PEP). It offers valuable, up-to-date evidence-based references for clinical practice, and the authors' efforts are highly commendable. Nevertheless, while acknowledging its contributions, two critical methodological limitations must be highlighted, which may compromise the interpretation and generalizability of its findings. The present commentary aims to identify two key methodological flaws in this meta-analysis that seriously undermine the statistical validity and clinical interpretability of its results. First, the authors inappropriately disaggregated seven multi-arm randomized controlled trials into multiple independent pairwise comparisons for inclusion in the analysis. This practice directly violates the core assumption of data independence in meta-analyses: different comparison groups derived from the same trial are correlated due to the shared control arm. Treating these as independent samples artificially inflates the total sample size, misestimates the weight of each study, and leads to an inappropriate narrowing of confidence intervals, thereby increasing the risk of Type I or Type II errors. Second, the definition of the "control group" in the study encompasses interventions with extremely high clinical heterogeneity, including placebo, normal saline, other active medications (e.g., diclofenac, somatostatin), and invasive procedures (e.g., pancreatic duct stenting). Pooling these controls with vastly different mechanisms of action and therapeutic efficacies renders the reported pooled relative risk (RR = 0.85) clinically meaningless. Furthermore, the high heterogeneity observed (I² = 79%) is most likely attributable to this flawed methodological design. In summary, the aforementioned issues cast doubt on the statistical credibility of the primary conclusion—that "indomethacin does not significantly reduce the incidence of PEP"—and also make it difficult to provide a reasonable clinical interpretation for practice. Given that this review incorporates multiple interrelated interventions for comparison, network meta-analysis would represent a more appropriate methodological framework. It can rigorously integrate data from multi-arm trials and simultaneously evaluate the relative efficacy of all relevant preventive strategies. "
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Tian F, Huang ZC, Khizar H, Qiu K. Efficacy of indomethacin for the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis: A comprehensive meta-analysis of randomized controlled trials. World J Gastroenterol 2026; 32(1): 113232
3
"This meta-analysis systematically retrieved and synthesized evidence from 30 randomized controlled trials (RCTs) involving nearly ..."
[Read more]
"This meta-analysis systematically retrieved and synthesized evidence from 30 randomized controlled trials (RCTs) involving nearly 17,000 patients, providing the most comprehensive assessment to date on the efficacy of indomethacin for preventing post-ERCP pancreatitis (PEP). It offers valuable, up-to-date evidence-based references for clinical practice, and the authors' efforts are highly commendable. Nevertheless, while acknowledging its contributions, two critical methodological limitations must be highlighted, which may compromise the interpretation and generalizability of its findings. The present commentary aims to identify two key methodological flaws in this meta-analysis that seriously undermine the statistical validity and clinical interpretability of its results. First, the authors inappropriately disaggregated seven multi-arm randomized controlled trials into multiple independent pairwise comparisons for inclusion in the analysis. This practice directly violates the core assumption of data independence in meta-analyses: different comparison groups derived from the same trial are correlated due to the shared control arm. Treating these as independent samples artificially inflates the total sample size, misestimates the weight of each study, and leads to an inappropriate narrowing of confidence intervals, thereby increasing the risk of Type I or Type II errors. Second, the definition of the "control group" in the study encompasses interventions with extremely high clinical heterogeneity, including placebo, normal saline, other active medications (e.g., diclofenac, somatostatin), and invasive procedures (e.g., pancreatic duct stenting). Pooling these controls with vastly different mechanisms of action and therapeutic efficacies renders the reported pooled relative risk (RR = 0.85) clinically meaningless. Furthermore, the high heterogeneity observed (I² = 79%) is most likely attributable to this flawed methodological design. In summary, the aforementioned issues cast doubt on the statistical credibility of the primary conclusion—that "indomethacin does not significantly reduce the incidence of PEP"—and also make it difficult to provide a reasonable clinical interpretation for practice. Given that this review incorporates multiple interrelated interventions for comparison, network meta-analysis would represent a more appropriate methodological framework. It can rigorously integrate data from multi-arm trials and simultaneously evaluate the relative efficacy of all relevant preventive strategies. "
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Ding Y, Wang CY, Pan YT, Wang YJ, Zhao AG, Wen HZ. Scutellaria baicalensis Georgi as a potential therapeutic drug intervention in ulcerative colitis: Mechanisms of action and clinical trials. World J Gastroenterol 2026; 32(1): 114558
4
"I read the excellent paper by Rajak et al. The review is organized and precisely addresses the role of microplastics in inducing ..."
[Read more]
"I read the excellent paper by Rajak et al. The review is organized and precisely addresses the role of microplastics in inducing metabolic-associated steatotic liver disease and its progression. The review raises a growing emergency: the relationship between air pollution and human health. This can be a stimulus for policymakers and international organizations to take concrete action. However, it should be remembered that a proper lifestyle can mitigate the negative impact of microplastics on the liver and human health in general. While waiting for long-term measures, this is information that can yield short-term results. On this issue, it will be my concern to send a letter to the editor. Sincerely, Gianni Testino "
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Rajak S, Shahi A, Yadav A, Medhe P, Sinha RA. Microplastics in metabolic dysfunction-associated steatotic liver disease: An emerging threat to liver health. World J Hepatol 2025; 17(12): 111198
5
"1.The article does not cover the temporal and spatial dynamic changes of inflammatory cytokines during the development of NSCLC, as ..."
[Read more]
"1.The article does not cover the temporal and spatial dynamic changes of inflammatory cytokines during the development of NSCLC, as well as how these changes affect the occurrence and development of drug resistance. For instance, are there any differences in the expression levels of inflammatory cytokines in the early stage, progression stage, and resistance stage of the tumor? Are their distributions different in various parts of the tumor (such as the primary lesion and metastatic lesion)? It is suggested to utilize techniques such as in situ hybridization and immunohistochemistry, combined with single-cell sequencing and spatial transcriptomics, to study the temporal and spatial dynamic changes of inflammatory cytokines in different development stages and different locations of NSCLC. By analyzing longitudinal samples of patients (such as before treatment, during treatment, and after resistance), the dynamic change patterns of inflammatory cytokines during the process of drug resistance can be revealed. 2. Although IL-6R blockade shows the effect of reversing drug resistance, single-target therapy may have limitations in efficacy or the risk of drug resistance escape. It is suggested to explore IL-6/IL-8 dual-target inhibition in preclinical models, or to combine it with downstream pathway inhibitors (such as JAK/STAT, PI3K/AKT, NF-κB inhibitors) or immune checkpoint inhibitors to evaluate its synergistic anti-tumor effect and its remodeling effect on the tumor microenvironment, in order to provide theoretical basis for future clinical trials of combination therapy. "
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Calibasi-Kocal G. Inflammatory cytokine-associated cisplatin resistance in non-small cell lung cancer and re-sensitization through interleukin-6 receptor blockade. World J Clin Oncol 2025; 16(12): 114275
6
"Author: Priya Hazrah Professor, Department of Surgery, Lady Hardinge Medical College, New Delhi. Email: priyahazrah@gmail.com, ORCID ..."
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"Author: Priya Hazrah Professor, Department of Surgery, Lady Hardinge Medical College, New Delhi. Email: priyahazrah@gmail.com, ORCID ID 0009-0008-1915-3978 Deborshi Sharma Director Professor Department of Surgey ABVIMS, New Delhi. Email: drdeborshi@gmail.com, ORCID ID 0000-0001-8251-8484 Sonali Mittal Assistant professor, Lady Hardinge Medical College, New Delhi Email: sonali.prachi@gmail.com, ORCID 0000-0002-6289-7656 Corresponding Author: Priya Hazrah Professor Department of Surgery, Lady Hardinge Medical College, New Delhi. Email: priyahazrah@gmail.com We read with tremendous interest your article entitled “Mastering the third space: Innovations in intramural endoscopic surgery for gastrointestinal disorders.” It was a very apt and concise review of commonly performed third space endoscopy (TSE) procedures, namely the C, Z, E, and G POEM (per oral endoscopic myotomy). Here, we would like to highlight other evolving procedures related to third space endoscopy and also the emerging concept of “fourth space endoscopy.” POETRE, peroral esophageal tunnelling for restoration of the esophagus, based on the principle of TSE, is an innovative technique of submucosal tunnelling proposed to be a useful therapeutic option in long-segment complete esophageal luminal obstruction in a few case series [1, 2]. PREM/PAEM (per rectal/per anal myotomy) is another novel use of TSE with limited exploration in patients with Hirschsprung’s disease [3]. STER (submucosal tunnelling endoscopic resection) and POET (peroral endoscopic excision of tumor) have been reported to be safe procedures for resection of extramucosal tumors in the upper gastrointestinal tract with acceptable complication rates vouched for in recent meta-analyses [4-7]. Further, TSE can be used to gain peritoneal access, as seen in POEM+F (POEM with fundoplication). Building upon the model of third space endoscopy is a forthcoming concept of fourth space endoscopy based on the technique of sub-serosal dissection for excision of extramucosal tumors in the upper gastrointestinal tract, like gastrointestinal stromal tumors, leiomyoma, hamartoma, etc., published in a limited case series [8]. The feasibility of using the principle of the fourth-space endoscopy procedure for vagotomy is investigational and has been reported currently in an anecdotal non-human study [9]. The fourth space is also utilized at times in POEM to enable a full-thickness myotomy [10]. References 1. Wagh MS, Draganov PV. Per-oral endoscopic tunneling for restoration of the esophagus: a novel endoscopic submucosal dissection technique for therapy of complete esophageal obstruction. Gastrointest Endosc. 2017 Apr;85(4):722-727. doi: 10.1016/j.gie.2016.08.035. Epub 2016 Sep 7. PMID: 27612924. 2. Félix C, Barreiro P, Rodrigues Azevedo J, Maia L, Küttner-Magalhães R, Pedroto I, Chagas C. Per-oral endoscopic tunneling for restoration of the esophagus (POETRE) in the management of a complete esophageal obstruction. Endosc Int Open. 2021 Jul;9(7):E1084-E1085. doi: 10.1055/a-1463-3059. Epub 2021 Jun 17. PMID: 34222634; PMCID: PMC8211479. 3. Bapaye A, Dashatwar P, Biradar V, Biradar S, Pujari R. Initial experience with per-rectal endoscopic myotomy for Hirschsprung's disease: medium and long term outcomes of the first case series of a novel third-space endoscopy procedure. Endoscopy. 2021 Dec;53(12):1256-1260. doi: 10.1055/a-1332-6902. Epub 2021 Mar 2. PMID: 33291158. 4. Onimaru M, Inoue H, Bechara R, Tanabe M, Abad MRA, Ueno A, Shimamura Y, Sumi K, Ikeda H, Ito H. Clinical outcomes of per-oral endoscopic tumor resection for submucosal tumors in the esophagus and gastric cardia. Dig Endosc. 2020 Mar;32(3):328-336. doi: 10.1111/den.13471. Epub 2019 Jul 22. PMID: 31234231. 5. Peng W, Tan S, Huang S, Ren Y, Li H, Peng Y, Fu X, Tang X. Efficacy and safety of submucosal tunneling endoscopic resection for upper gastrointestinal submucosal tumors with more than 1-year' follow-up: a systematic review and meta-analysis. Scand J Gastroenterol. 2019 Apr;54(4):397-406. doi: 10.1080/00365521.2019.1591500. Epub 2019 Mar 29. PMID: 30925071. 6. Song S, Wang X, Zhang S, Li Y, Zhang X, Chu X. Efficacy and complications of submucosal tunneling endoscopic resection for upper gastrointestinal submucosal tumors and exploration for influencing factors. Z Gastroenterol. 2018 Apr;56(4):365-373. English. doi: 10.1055/s-0043-123765. Epub 2018 Jan 18. PMID: 29346827. 7. Cao B, Lu J, Tan Y, Liu D. Efficacy and safety of submucosal tunneling endoscopic resection for gastric submucosal tumors: a systematic review and meta-analysis. Rev Esp Enferm Dig. 2021 Jan;113(1):52-59. doi: 10.17235/reed.2020.6989/2020. PMID: 33222480. 8. Liu F, Zhang S, Ren W, Yang T, Lv Y, Ling T, Zou X, Wang L. The fourth space surgery: endoscopic subserosal dissection for upper gastrointestinal subepithelial tumors originating from the muscularis propria layer. Surg Endosc. 2018 May;32(5):2575-2582. doi: 10.1007/s00464-017-5985-z. Epub 2017 Dec 20. PMID: 29264757. 9. Kadkhodayan K, Irani S. Endoscopic truncal vagotomy. Exploring the fourth space. A technical feasibility study in a porcine model. VideoGIE. 2025 Mar 4;10(7):340-344. doi: 10.1016/j.vgie.2025.02.012. PMID: 40642399; PMCID: PMC12237756. 10. Jiang T, Yang Y, Luo W. Application of the fourth space in peroral endoscopic myotomy (POEM) surgery for achalasia. Rev Esp Enferm Dig. 2025 Jun 27. doi: 10.17235/reed.2025.11331/2025. Epub ahead of print. PMID: 40575899. "
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Restrepo-Rodas G, Rodriguez J. Mastering the third space: Innovations in intramural endoscopic surgery for gastrointestinal disorders. World J Gastrointest Endosc 2025; 17(12): 111206
7
"This article addresses an important and timely topic: differentiation-based strategies for colorectal cancer (CRC) therapy using ..."
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"This article addresses an important and timely topic: differentiation-based strategies for colorectal cancer (CRC) therapy using natural products. The authors present a comprehensive in vitro study suggesting that Ferula assafoetida (FA) induces differentiation and apoptosis in Caco-2 colon cancer cells, potentially via activation of the JNK/MAPK pathway. As a reader, the work is interesting, methodologically broad, and conceptually aligned with current interests in natural compound–based cancer therapeutics, although certain conceptual and interpretative gaps limit its translational impact. As a reader, I would regard this article as a useful exploratory study that justifies further mechanistic, protein-level, and in vivo investigations, rather than a conclusive demonstration of FA as a differentiation therapy for CRC. "
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Abdelsalam HM, Abdelghany AM, Ahmed WA, Diab AA, Abdellateif MS. Ferula assafoetida induced colon cancer cells differentiation through JNK/MAPK signalling pathway activation. World J Exp Med 2025; 15(4): 110757
8
"his retrospective study by Cooper et al. provides a valuable comparison of endoscopic band ligation (EBL) and endoscopic thermal ..."
[Read more]
"his retrospective study by Cooper et al. provides a valuable comparison of endoscopic band ligation (EBL) and endoscopic thermal therapy (ETT) as initial treatments for nodular gastric antral vascular ectasia (GAVE), a rare and challenging subtype. The analysis of 37 patients demonstrates that EBL outperforms ETT, with significantly higher clinical remission rates (90% vs. 69%, P=0.041), shorter treatment intervals (172 vs. 928 days, P=0.013), and fewer required endoscopic sessions (1.95 vs. 5.56, P=0.009), supported by improved hemoglobin levels and reduced transfusions. The findings robustly advocate for EBL as a first-line approach due to its efficiency and lower treatment burden. However, limitations include the small sample size, single-center design, and retrospective nature, which may affect generalizability. Despite this, the study fills a critical gap in nodular GAVE management and underscores the need for prospective multicenter trials to validate EBL's superiority and optimize clinical protocols. "
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Cooper JA, Statham E, Holyfield A, Shoreibah MG, Peter S. Initial treatment approaches for nodular gastric antral vascular ectasia: A comparison of endoscopic band ligation and thermal therapies. World J Gastrointest Endosc 2025; 17(12): 111872
9
"The minireview by El Dada et al. offers a timely synthesis of endoscopic ultrasound (EUS)-guided coil embolization for gastric varices ..."
[Read more]
"The minireview by El Dada et al. offers a timely synthesis of endoscopic ultrasound (EUS)-guided coil embolization for gastric varices (GVs), highlighting its potential as a safer, precise alternative to traditional therapies like cyanoacrylate injection. Strengths include systematic comparisons with meta-analytic data (e.g., 96.7% obliteration rate for EUS-coil/cyanoacrylate vs. 70.6% for cyanoacrylate alone), practical technical details (coil selection, Doppler confirmation), real-world case illustrations, and cost-effectiveness analysis (1,831vs.11,000 hospitalization). However, limitations persist: reliance on retrospective/single-center data, absence of randomized controlled trials (RCTs) against TIPS/BRTO, and lack of long-term (>5 years) rebleeding/complication data (e.g., coil migration). The authors appropriately call for multicenter RCTs to standardize protocols, explore material combinations, and integrate predictive biomarkers. Despite gaps, the review compellingly argues for EUS-coil’s inclusion in GV guidelines, serving as a valuable reference for advancing therapeutic endoscopy with balanced analysis of efficacy, safety, and accessibility. "
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El Dada A, El Khoury M, Stephan P, Nehme F. Endoscopic ultrasound-guided coil embolization for gastric varices: A promising alternative to traditional therapies. World J Gastrointest Endosc 2025; 17(12): 110168
10
"Name of Journal: World Journal of Gastroenterology Manuscript Type: LETTER TO THE EDITOR Dialister-Associated Succinate Dysregulation ..."
[Read more]
"Name of Journal: World Journal of Gastroenterology Manuscript Type: LETTER TO THE EDITOR Dialister-Associated Succinate Dysregulation in Crohn’s Disease: Clinical and Therapeutic Implications 1Fotios S. Fousekis, 1Konstantinos H. Katsanos, 2Konstantinos Vlachos, 2Georgios D. Lianos 1Department of Gastroenterology, University Hospital of Ioannina, University of Ioannina Ioannina, Greece 2Department of Surgery, University Hospital of Ioannina, University of Ioannina, Greece Corresponding author: Fotios S. Fousekis, MD, PhD, Department of Gastroenterology, University Hospital of Ioannina, University of Ioannina Ioannina, Greece, email: fotisfous@gmail.com Abstract Growing evidence suggests that altered gut microbiota–derived succinate metabolism plays an important role in Crohn’s disease activity and postoperative recurrence. Particular emphasis is placed on Dialister, a gut bacterial genus that consumes succinate inefficiently, potentially leading to its accumulation and increased intestinal inflammation. Elevated succinate may impair immune regulation and enhance inflammatory signaling through SUCNR1 activation and hypoxia-inducible factor-1α stabilization. Recent findings identifying specific Dialister strains associated with postoperative recurrence provide new insight into disease monitoring and risk stratification. Although the study offers an integrative view linking microbial composition, metabolism, and inflammation, further validation using direct metabolomic and shotgun metagenomic approaches is needed. Overall, succinate appears to be a promising biomarker and therapeutic target, supporting future microbiota- and metabolism-based strategies for the management of inflammatory bowel disease. Key words: Crohn’s disease; Inflammatory bowel disease; Gut microbiota; Succinate; Dialister; Postoperative recurrence Core tip Accumulation of the microbial metabolite succinate is increasingly recognized as a key driver of inflammation in Crohn’s disease. Recent evidence links Dialister enrichment to impaired succinate clearance, disease activity, and postoperative recurrence, highlighting succinate as a promising biomarker and therapeutic target in inflammatory bowel disease. To the editor Dialister, an anaerobic Gram-negative genus of the human gut microbiome, has gained clinical interest due to its role in succinate metabolism. While capable of utilizing succinate as a substrate for propionate production, Dialister exhibits relatively slow consumption rates compared with efficient succinate consumers such as Phascolarctobacterium. This inefficiency may result in elevated luminal succinate levels, particularly in the context of inflammatory bowel disease (IBD) (1). Succinate accumulation may disrupt regulatory T cell (Treg) function by promoting FOXP3 degradation, thereby reducing immune tolerance and further amplifying inflammation (2). Furthermore, elevated succinate stabilizes hypoxia-inducible factor-1α (HIF-1α) by inhibiting prolyl hydroxylase activity, which prevents HIF-1α degradation and leads to enhanced inflammatory gene expression and perpetuation of tissue injury, particularly in IBD (3). We read with great interest the recently published article by Boronat-Toscano and colleagues on Dialister-driven succinate accumulation and its association with disease activity and postoperative recurrence in Crohn’s disease (4). This study offers valuable insights into a rapidly growing field of research that links gut microbiota, host metabolism, and inflammation. It positions succinate not just as a metabolic by-product but also as a functional biomarker and potential therapeutic target. One of the major strengths of this work is its integrative, multi-level approach, which combines clinical and biochemical measures of disease activity, such as the Harvey–Bradshaw Index, C-reactive protein, and fecal calprotectin, with gut microbiome profiling using 16S rRNA sequencing and host molecular markers related to succinate signaling, specifically the expression of the succinate receptor SUCNR1 (4). Notably, this study highlights specific Dialister operational taxonomic units (OTUs) in the intestinal mucosa that correlate with the risk and severity of postoperative recurrence. This goes beyond existing knowledge by identifying strain-level microbial signatures with potential predictive value, suggesting that variability within Dialister is vital for patient stratification and disease progression after surgery. The authors also propose a mechanism for succinate accumulation in Crohn's disease, involving the downregulation of NADH dehydrogenase and the upregulation of fumarate reductase and succinate transporters. This metabolic shift enhances succinate production and export by the gut microbiota (4). Despite these strengths, we would like to highlight several issues that merit further discussion. The functional analysis of the gut microbiome is based on predictive approaches (PICRUSt2) rather than on direct measurements of metabolic fluxes or shotgun metagenomic sequencing. Validation of these predictions is essential for robust conclusions. Targeted metabolomic analyses, using mass spectrometry or nuclear magnetic resonance, allow for direct quantification of metabolites as succinate and can confirm the functional activity of predicted pathways (5). In addition shotgun metagenomic sequencing may provide a more comprehensive and direct assessment of the genetic potential for metabolic pathways, including those involved in succinate production and consumption, by sequencing all microbial DNA present in a sample (6). These findings also open important avenues for future research and therapeutic development in inflammatory bowel disease. Given the central role of succinate in promoting intestinal inflammation through SUCNR1 activation and HIF-1α stabilization, strategies aimed at reducing succinate accumulation or blocking its downstream signaling pathways warrant further investigation. Microbiota-targeted interventions, including dietary fiber enrichment, prebiotics, and probiotics designed to enhance the abundance of efficient succinate-consuming bacteria such as Phascolarctobacterium, represent a particularly promising approach, as preclinical studies have demonstrated their ability to lower succinate levels, attenuate inflammatory signaling, and restore epithelial barrier integrity (7). Avoiding supplementation of the diet with refined inulin may be considered, as evidence from mouse models suggests that it can induce abnormal succinate accumulation in the intestinal lumen, thereby contributing to colonic inflammation (8). In parallel, pharmacological inhibition of SUCNR1 using small-molecule antagonists, as well as interventions targeting HIF-1α stabilization, may offer complementary strategies to suppress succinate-driven inflammation (9, 10). Huo et al. demonstrated that the SUCNR1 inhibitor NF-56-EJ40 may suppress glycolysis in intestinal epithelial cells and attenuates Th17-mediated inflammation in a dextran sodium sulfate–induced mouse model of ulcerative colitis. Treatment reduced pro-inflammatory cytokine production, improved epithelial barrier integrity, and alleviated colonic injury, supporting SUCNR1 antagonism as a therapeutic strategy targeting both metabolic and immune pathways (7). Consistently, genetic deletion of SUCNR1 in mice protected against both acute colitis and intestinal fibrosis, while in human fibroblasts derived from Crohn’s disease patients, succinate increased SUCNR1 expression and promoted inflammatory and fibrotic markers that were effectively reversed by SUCNR1 blockade (11). While these approaches are supported by growing mechanistic and translational evidence, well-designed clinical trials will be essential to determine their efficacy and safety in patients with IBD. Conclusion The study conducted by Boronat-Toscano et al. enhances the understanding of how microbiota-driven metabolic dysregulation relates to Crohn’s disease by identifing succinate and Dialister-associated microbial signatures associated as important factors that influence disease activity and the likelihood of postoperative recurrence. These findings support the use of succinate-related biomarkers in future risk assessment and postoperative monitoring strategies. Additionally, they provide a strong biological basis for therapeutic interventions that target succinate metabolism or SUCNR1-mediated signaling. Overall, this study marks a crucial step towards developing metabolically informed, microbiome-based precision medicine for IBD. Author contributions: Fousekis FS wrote the original draft; Lianos GD contributed to conceptualization, writing, reviewing and editing; Katsanos KH and Vlachos K participated in drafting the manuscript; and all authors have read and approved the final version of the manuscript. References 1. Anthamatten L, von Bieberstein PR, Menzi C, Zund JN, Lacroix C, de Wouters T, Leventhal GE. Stratification of human gut microbiomes by succinotype is associated with inflammatory bowel disease status. Microbiome. 2024;12(1):186. PMID: 39350289 PMCID: PMC11441152 DOI: 10.1186/s40168-024-01897-8 2. Wang H, Hu D, Cheng Y, Gao Q, Liu K, Mani NL, Tang AY, Iyer R, Gao B, Zhou Q, Yu Q, Weinberg SE, Zhang X, Cong Y, Dulai PS, Zhang Y, Liu Z, Fang D. Succinate drives gut inflammation by promoting FOXP3 degradation through a molecular switch. Nat Immunol. 2025;26(6):866-80. PMID: 40457062 PMCID: PMC12399925 DOI: 10.1038/s41590-025-02166-y 3. Tannahill GM, Curtis AM, Adamik J, Palsson-McDermott EM, McGettrick AF, Goel G, Frezza C, Bernard NJ, Kelly B, Foley NH, Zheng L, Gardet A, Tong Z, Jany SS, Corr SC, Haneklaus M, Caffrey BE, Pierce K, Walmsley S, Beasley FC, Cummins E, Nizet V, Whyte M, Taylor CT, Lin H, Masters SL, Gottlieb E, Kelly VP, Clish C, Auron PE, Xavier RJ, O'Neill LAJ. Succinate is an inflammatory signal that induces IL-1beta through HIF-1alpha. Nature. 2013;496(7444):238-42. PMID: 23535595 PMCID: PMC4031686 DOI: 10.1038/nature11986 4. Boronat-Toscano A, Queipo-Ortuño MI, Monfort-Ferré D, Suau R, Vañó-Segarra I, Valldosera G, Cepero C, Astiarraga B, Clua-Ferré L, Plaza-Andrade I, Aranega-Martín L, Cabrinety L, Abadia de Barbarà C, Castellano-Castillo D, Moliné A, Caro A, Domènech E, Sánchez-Herrero JF, Benaiges-Fernandez R, Fernández-Veledo S, Vendrell J, Ginés I, Sumoy L, Manyé J, Menacho M, Serena C. Dialister-driven succinate accumulation is associated with disease activity and postoperative recurrence in Crohn's disease. World J Gastroenterol. 2025;31(45):112618. PMID: 41378335 PMCID: PMC12687013 DOI: 10.3748/wjg.v31.i45.112618 5. Han S, Van Treuren W, Fischer CR, Merrill BD, DeFelice BC, Sanchez JM, Higginbottom SK, Guthrie L, Fall LA, Dodd D, Fischbach MA, Sonnenburg JL. A metabolomics pipeline for the mechanistic interrogation of the gut microbiome. Nature. 2021;595(7867):415-20. PMID: 34262212 PMCID: PMC8939302 DOI: 10.1038/s41586-021-03707-9 6. Mitra S, Forster-Fromme K, Damms-Machado A, Scheurenbrand T, Biskup S, Huson DH, Bischoff SC. Analysis of the intestinal microbiota using SOLiD 16S rRNA gene sequencing and SOLiD shotgun sequencing. BMC Genomics. 2013;14 Suppl 5(Suppl 5):S16. PMID: 24564472 PMCID: PMC3852202 DOI: 10.1186/1471-2164-14-S5-S16 7. Huo L, Chen Q, Jia S, Zhang Y, Wang L, Li X, Li Z, Sun B, Shan J, Lin J, Yang L, Sui H. Gut microbiome promotes succinate-induced ulcerative colitis by enhancing glycolysis through SUCNR1/NF-kappaB signaling pathway. Am J Physiol Cell Physiol. 2025;329(2):C440-C54. PMID: 40549551 DOI: 10.1152/ajpcell.00411.2025 8. Tian S, Paudel D, Hao F, Neupane R, Castro R, Patterson AD, Tiwari AK, Prabhu KS, Singh V. Refined fiber inulin promotes inflammation-associated colon tumorigenesis by modulating microbial succinate production. Cancer Rep (Hoboken). 2023;6(11):e1863. PMID: 37489647 PMCID: PMC10644334 DOI: 10.1002/cnr2.1863 9. Haffke M, Fehlmann D, Rummel G, Boivineau J, Duckely M, Gommermann N, Cotesta S, Sirockin F, Freuler F, Littlewood-Evans A, Kaupmann K, Jaakola VP. Structural basis of species-selective antagonist binding to the succinate receptor. Nature. 2019;574(7779):581-5. PMID: 31645725 DOI: 10.1038/s41586-019-1663-8 10. Kim YI, Yi EJ, Kim YD, Lee AR, Chung J, Ha HC, Cho JM, Kim SR, Ko HJ, Cheon JH, Hong YR, Chang SY. Local Stabilization of Hypoxia-Inducible Factor-1alpha Controls Intestinal Inflammation via Enhanced Gut Barrier Function and Immune Regulation. Front Immunol. 2020;11:609689. PMID: 33519819 PMCID: PMC7840603 DOI: 10.3389/fimmu.2020.609689 11. Macias-Ceja DC, Ortiz-Masia D, Salvador P, Gisbert-Ferrandiz L, Hernandez C, Hausmann M, Rogler G, Esplugues JV, Hinojosa J, Alós R; Navarro F, Cosin-Roger J, Calatayud S, Barrachina MD. Succinate receptor mediates intestinal inflammation and fibrosis. Mucosal Immunol. 2019;12(1):178-87. PMID: 30279517 DOI: 10.1038/s41385-018-0087-3 "
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Boronat-Toscano A, Queipo-Ortuño MI, Monfort-Ferré D, Suau R, Vañó-Segarra I, Valldosera G, Cepero C, Astiarraga B, Clua-Ferré L, Plaza-Andrade I, Aranega-Martín L, Cabrinety L, Abadia de Barbarà C, Castellano-Castillo D, Moliné A, Caro A, Domènech E, Sánchez-Herrero JF, Benaiges-Fernandez R, Fernández-Veledo S, Vendrell J, Ginés I, Sumoy L, Manyé J, Menacho M, Serena C. Dialister-driven succinate accumulation is associated with disease activity and postoperative recurrence in Crohn’s disease. World J Gastroenterol 2025; 31(45): 112618
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"This minireview systematically synthesizes the intricate interplay between depression and gastric cancer (GC), incorporating ..."
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"This minireview systematically synthesizes the intricate interplay between depression and gastric cancer (GC), incorporating neuroendocrine, immunological, and psychosocial mechanisms. The authors effectively underscore the bidirectional causality supported by 52 referenced studies, in alignment with the biopsychosocial model. Nonetheless, there are opportunities to enhance methodological rigor and visual communication. Although Figure 1 delineates key components of the bidirectional relationship, its informational density is suboptimal. The figure lacks a hierarchical structuring of pathways (e.g., neuroendocrine versus immune mechanisms) and does not quantify effect sizes (e.g., hazard ratios from cited meta-analyses). It is recommended to incorporate a summary table for comparison. "
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Chen Z, Gong TJ, Zhao L. Bidirectional relationship between depression and the risk and prognosis of gastric cancer. World J Gastrointest Oncol 2025; 17(12): 113272
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"I want to congratulate the authors, Zhang et al, for conducting a study and identifying the predictors of refractory GERD. They have ..."
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"I want to congratulate the authors, Zhang et al, for conducting a study and identifying the predictors of refractory GERD. They have identified the disease duration and anxiety as significant risk factors and at least 90 minutes of moderate-intensity physical activity per week as a protective factor for refractory GERD. One of the important findings in this study is the association of significant Overlap DGBI symptoms (such as dyspepsia, constipation, and diarrhoea) in at least 50% of GERD patients. Since most patients had a duration of illness of more than 4 years, complications of GERD and their comparison between the groups were not noted in this study (a limitation). Although hydrogen impedance is used for diagnosis, the comparison of impedance parameters is not provided. H pylori infection is a protective factor for GERD/Barrett's, which is also a limitation. This study has provided a meaningful conclusion regarding the association between long-term symptoms and refractoriness. "
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Zhang N, Wang Y, Fang SS, Han M, Zheng QW, Zhu YY, Zhang MY, Li JJ, Cui LX, Tian JL, Deng YH, Zhu SL, Ni HM, Zhou L, Zuo GL, Huang TS, Liao Q, Li XQ, Shang YY, Wang YJ, Tian Y, Ge LY, Han HQ, Hu WM, Jiang Y, Li YJ, Mao X, Yang LH, Yao JM, Zheng X, Wang HW, Fang SQ. Clinical characteristics and risk factors of refractory gastroesophageal reflux disease: A multicenter cross-sectional study. World J Gastroenterol 2025; 31(45): 113060
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"The present Letter provides a concise academic response to the article identified by Reader’s code 05354032. The comments focus on ..."
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"The present Letter provides a concise academic response to the article identified by Reader’s code 05354032. The comments focus on several important aspects of the study, including its methodological design, data interpretation, and clinical applicability. The aim is to offer constructive perspectives that may help clarify key issues and support future improvements in related research. "
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Ardila CM, Ángel-Estrada S, González-Arroyave D. Robot-assisted vs conventional lumbar interbody fusion: A systematic review and meta-analysis of perioperative, radiographic, and clinical outcomes. World J Orthop 2025; 16(11): 110276
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"The study title "Comparison of the efficacy of laparoscopic hepatectomy and radiofrequency ablation for small hepatocellular ..."
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"The study title "Comparison of the efficacy of laparoscopic hepatectomy and radiofrequency ablation for small hepatocellular carcinoma: A retrospective study" by Lei et al. aims to compare the long-term survival and perioperative outcomes of Laparoscopic hepatectomy (LH) and radiofrequency ablation (RFA) for small hepatocellular carcinoma (HCC). This retrospective study included 254 patients with small HCC who were collected from Hospital of Chongqing Medical University between December 2022 and March 2025. The results showed that LH was associated with longer operative time, greater blood loss, prolonged recovery, higher costs, and increased complication rates. Consequently, LH, though associated with increased perioperative morbidity, provides superior long-term survival outcomes compared with RFA in patients with small HCC. This study had many limitations such as potential for selection bias and confounding factors that were not controlled for is inherent. The decision to undergo either LH or RFA was made based on clinical judgment and patient-specific factors, which could introduce bias. The sample size was still be insufficient to detect subtle differences in outcomes between the two modalities, especially for subgroups with specific tumor characteristics or comorbidities. Moreover, LH and RFA techniques have evolved over time, and variations in operator experience and institutional protocols could influence outcomes. "
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Lei ZL, Tan ZL, Luo YH, Yang M, Wang JL, Qin Z, Liu YY. Comparison of the efficacy of laparoscopic hepatectomy and radiofrequency ablation for small hepatocellular carcinoma: A retrospective study. World J Gastroenterol 2025; 31(45): 111540
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"We are delighted to read the high-quality review by Zheng et al[1], published in the World Journal of Gastroenterology, which offers ..."
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"We are delighted to read the high-quality review by Zheng et al[1], published in the World Journal of Gastroenterology, which offers insightful perspectives on the neuroimmune mechanisms contributing to the pathogenesis of inflammatory bowel disease (IBD). The intricate interplay between the autonomic nervous system (ANS) and the immune response, particularly involving vagus nerve stimulation (VNS) and its effects on macrophages, provides a promising avenue for future therapeutic interventions in IBD. The review underscores the emerging concept of neuroimmune interactions, particularly the cholinergic anti-inflammatory pathway (CAIP), which regulates inflammation through the vagus nerve and its interaction with intestinal macrophages. This is an exciting area of research, especially in the context of IBD, where inflammation is at the heart of the disease's pathology. Macrophages, as highlighted in the review, play a crucial role in maintaining intestinal homeostasis, but when overactivated, they contribute to the excessive production of proinflammatory cytokines, exacerbating the condition. This review draws attention to how the cholinergic system can modulate macrophage activity, reducing the inflammatory burden through the activation of the α7 nicotinic acetylcholine receptor (α7nAChR). The role of VNS as an approach to activate the cholinergic pathway and regulate inflammation in IBD is a breakthrough concept. Studies showing the beneficial effects of VNS in reducing inflammation and enhancing immune tolerance are promising, offering a potential alternative to conventional treatments, especially in patients with refractory IBD. Furthermore, the use of VNS to modulate the autonomic nervous system offers a unique therapeutic strategy for restoring balance between sympathetic and parasympathetic tones in patients, whose autonomic dysfunction may contribute to disease exacerbation. While the current data on VNS in IBD are promising, the review rightly calls for further research to better establish the clinical applicability of VNS, especially through non-invasive techniques such as transauricular and transcervical VNS. These methods, as highlighted, may offer a safer and more accessible alternative to invasive VNS, which has shown positive effects in treating other inflammatory conditions. The ongoing exploration of VNS in clinical trials, coupled with advancements in understanding the mechanisms of cholinergic signaling in immune cells, opens new avenues for therapeutic interventions in chronic inflammatory diseases. However, as the review mentions, there are still challenges that need to be addressed. The precise mechanisms through which VNS modulates immune responses, particularly in macrophages, are still under investigation. Additionally, while VNS has shown potential in preclinical models, there is a need for larger, well-designed clinical studies to confirm the safety, efficacy, and long-term benefits of VNS in IBD patients. The heterogeneity of IBD, along with differences in patient responses to treatment, further complicates the development of standardized protocols for VNS treatment. In conclusion, the review provides an excellent overview of the current state of research on neuroimmune interactions in IBD, with a special focus on the potential of VNS as a novel therapeutic strategy. The integration of neuroimmune regulation, particularly through the cholinergic pathway, into the treatment of IBD represents an innovative approach that could offer significant improvements in patient outcomes. As we move forward, I hope that the continued research in this field will provide more concrete evidence to support the use of VNS in clinical practice, potentially offering a transformative treatment for IBD patients who have not responded to traditional therapies. LIMITATIONS OF THE REVIEW While the review provides a comprehensive overview of the potential therapeutic role of vagus nerve stimulation (VNS) in inflammatory bowel disease (IBD), there are some limitations that should be addressed in future research. First, while the article highlights the promising effects of VNS, particularly through the cholinergic anti-inflammatory pathway (CAIP), there is a lack of in-depth discussion regarding the specific cellular mechanisms involved. The exact signaling pathways through which VNS modulates macrophage activity and alters immune responses remain unclear, and more detailed mechanistic studies are needed to provide a clearer understanding. Additionally, the review does not fully address the challenges associated with the translation of VNS into clinical practice. For instance, the variability in patient response to VNS, the optimal stimulation parameters (e.g., frequency, duration, and intensity), and the potential side effects of VNS, particularly in IBD patients with coexisting conditions, are aspects that require more attention. Lastly, the review focuses primarily on the autonomic nervous system's role in IBD, but it overlooks other possible neuroimmune interactions that could also influence disease progression. A broader exploration of how other neural pathways or neuropeptides contribute to IBD would provide a more comprehensive view of the neuroimmune mechanisms at play. CONCLUSION The review provides an insightful exploration of the neuroimmune mechanisms involved in inflammatory bowel disease (IBD), particularly focusing on the role of intestinal macrophages and the cholinergic anti-inflammatory pathway. Vagus nerve stimulation (VNS) represents a promising non-invasive therapeutic approach for modulating the immune system and controlling inflammation in IBD. However, further research is needed to fully understand the mechanisms behind VNS and to establish its efficacy in clinical settings for treating chronic inflammatory diseases such as IBD. With the development of non-invasive VNS technologies, future therapies may offer safer and more effective treatments for patients suffering from IBD. "
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Zheng L, Duan SL. Neuroimmune interactions in inflammatory bowel disease: Role of intestinal macrophages and the cholinergic pathway. World J Gastroenterol 2025; 31(44): 109440
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"This editorial provides a comprehensive and insightful overview of self-expandable metal stents (SEMS) in acute colonic obstruction, ..."
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"This editorial provides a comprehensive and insightful overview of self-expandable metal stents (SEMS) in acute colonic obstruction, standing out for its clinical relevance and systematic organization. The authors adeptly synthesize cutting-edge techniques (e.g., fluoroscopy-free stenting, two-person colonoscopy) and critical considerations like stent design selection, backed by high-quality recent evidence, which offers valuable guidance for clinical practice. The discussion of complications and mitigation strategies is pragmatic, while the exploration of future directions (e.g., zero-border stents, multidisciplinary collaboration) reflects a forward-thinking perspective. The academic expression is precise and fluent, with consistent use of professional terminology and clear logical progression. A minor suggestion is to include brief comparative data on cost-effectiveness among different stenting techniques or stent types, which would further assist healthcare institutions in decision-making. Overall, this is a high-quality, clinically impactful piece that serves as an excellent reference for gastroenterologists and surgeons specializing in colorectal disorders. "
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Sun HY, Li ZC, Wang HL. Current mechanisms and techniques for placement of self-expandable metal stents in acute colonic obstruction. World J Gastrointest Surg 2025; 17(11): 110512
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"The editorial authored by Watanabe presents a timely and clinically pertinent overview of lisocabtagene maraleucel (liso-cel) CAR-T ..."
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"The editorial authored by Watanabe presents a timely and clinically pertinent overview of lisocabtagene maraleucel (liso-cel) CAR-T therapy, specifically addressing nodal and gastrointestinal follicular lymphoma (GI-FL). The author skillfully amalgamates essential findings from the TRANSCEND FL trial, emphasizing the extraordinary 97% overall response rate and a 94% complete response rate, alongside a notably reduced toxicity profile where grade ≥3 cytokine release syndrome (CRS) was absent, and grade ≥3 neurotoxicity was observed in merely 3% of patients. This concentrated analysis on the unique advantages of liso-cel—particularly its defined CD4+/CD8+ composition and the feasibility of outpatient treatment—addresses a significant void in the existing literature, especially in light of the historical exclusion of GI-FL from crucial CAR-T trials. The comparative framework juxtaposing lisocabtagene maraleucel with axicabtagene ciloleucel and tisagenlecleucel provides invaluable insights for clinical decision-making. Nevertheless, the editorial's otherwise robust examination fails to explore subtleties regarding the durability of response in high-risk subpopulations. Although the reported 12-month progression-free survival rate exceeding 85% is promising, emerging data indicate that follicular lymphoma patients with specific genomic alterations (e.g., TP53 mutations or 1p36 deletions) display varied responsiveness to CAR-T therapy. This omission is particularly salient for GI-FL, where the biological characteristics of the disease may diverge from those of nodal FL due to influences from the microenvironment. Furthermore, the editorial rightly recognizes cost as a barrier but insufficiently emphasizes how the manufacturing logistics of Liso-Cel disproportionately hinder accessibility in advanced GI-FL cases. Unlike nodal FL, where treatment delays may be manageable, GI-FL frequently presents urgent complications necessitating swift intervention. The three-week manufacturing timeline for liso-cel—despite improvements over previous platforms—remains a challenge for these patients, a difficulty exacerbated by the absence of validated bridging strategies tailored to gastrointestinal involvement. Looking ahead, the integration of endoscopic and molecular staging systems (e.g., Paris classification) with CAR-T therapy response biomarkers emerges as a critical research priority. Real-world studies should specifically investigate GI-FL cohorts to ascertain whether mucosal disease localization influences CAR-T trafficking or persistence. Additionally, the formulation of risk-adapted conditioning regimens could optimize the therapeutic index in patients with gastrointestinal involvement, where organ-specific toxicities remain inadequately characterized. Watanabe's appeal for multicenter collaboration should explicitly encompass these mechanistic and health-services research inquiries to propel personalized CAR-T applications across follicular lymphoma subtypes. "
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Watanabe T. Emerging role of lisocabtagene maraleucel chimeric antigen receptor-T cell in nodal and gastrointestinal follicular lymphoma. World J Gastroenterol 2025; 31(45): 112336
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"This review elevates our understanding of acetaminophen (APAP)-induced acute liver injury from a “single toxic metabolite acting on ..."
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"This review elevates our understanding of acetaminophen (APAP)-induced acute liver injury from a “single toxic metabolite acting on hepatocytes” model to a dynamic network involving multiple hepatic cell populations. Second, it clearly maps out current and potential therapeutic targets, essentially providing a “cell-type–oriented treatment roadmap” for future translational work. The discussion of CYP2E1/CYP3A4, species differences, and risk factors (such as alcohol use, malnutrition, underlying liver disease, and concomitant enzyme-inducing drugs) helps clinicians better identify high-risk populations and appreciate the limitations of extrapolating from animal models, thereby supporting more individualized risk assessment and dosing. In the treatment section, the authors extend beyond the classical “N-acetylcysteine golden window” and cover emerging strategies such as inhibition of NAPQI formation (e.g. fomepizole), mitochondria-targeted antioxidants (Mito-Tempo, MitoQ), modulation of ferroptosis/ferritinophagy, NLRP3–STING inflammasome pathways, as well as cell-based and hepatocyte transplantation therapies. This allows clinical readers to quickly grasp potential combination or alternative approaches that are entering or approaching clinical trials, while signaling to basic scientists multiple promising cellular pathways and targets for deeper exploration. Overall, the article reads as an up-to-date progress review on the multicellular mechanisms and therapeutic targets of APAP-induced acute liver injury, offering both mechanistic clarity and topic inspiration for those working on drug-induced liver injury, emergency/critical care, and liver transplantation—while also realistically emphasizing that most of the evidence remains at the experimental or early translational stage and is not yet ready to change clinical guidelines. "
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Yang D, Kim B, Kim JW. Mechanistic insights into hepatic cell type-specific contributions to acetaminophen-induced acute liver injury. World J Gastroenterol 2025; 31(45): 112720
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"this review provides a clear and systematic overview of the interactions among intestinal macrophages, the enteric nervous system, ..."
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"this review provides a clear and systematic overview of the interactions among intestinal macrophages, the enteric nervous system, and the cholinergic anti-inflammatory pathway in inflammatory bowel disease (IBD). By closely linking basic mechanistic insights with the potential clinical application of vagus nerve stimulation (VNS)—especially low-frequency, non-invasive VNS—the paper offers a fresh “neuroregulation–immune modulation” angle on IBD treatment, which is currently dominated by immunosuppressants and biologics. In terms of clinical practicality, the authors emphasize the promise of non-invasive VNS as a safer and more tolerable approach, while frankly acknowledging that current evidence still largely comes from animal models and a few pilot clinical studies, with a lack of large-scale randomized controlled trials. This “promising yet cautious” tone is valuable for clinical readers. On the one hand, the paper helps gastroenterologists and basic scientists understand why heart rate variability (HRV), emotional status, and autonomic imbalance may be linked to IBD course and relapse; on the other hand, it reminds readers that VNS and α7nAChR-targeted agents are still at the stages of proof-of-concept and early translation. In the short term, their main value lies in inspiring new research designs (for example, clinical trials stratified by HRV, combined with intestinal macrophage phenotype analysis), rather than immediately changing standard treatment pathways. Overall, this work reads like a forward-looking “blueprint” for neuro-immune therapies in IBD and is particularly thought-provoking for readers interested in IBD mechanisms and novel therapeutic strategies. "
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Zheng L, Duan SL. Neuroimmune interactions in inflammatory bowel disease: Role of intestinal macrophages and the cholinergic pathway. World J Gastroenterol 2025; 31(44): 109440
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"Commentary on "Large Language Models and Large Concept Models in Radiology: Present Challenges, Future Directions, and Critical ..."
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"Commentary on "Large Language Models and Large Concept Models in Radiology: Present Challenges, Future Directions, and Critical Perspectives" The transition from LLMs to LCMs, aiming for enhanced semantic reasoning, is fundamentally challenged by the necessity of building these sophisticated models upon historical data streams polluted by human cognitive biases [1]. Diagnostic interpretation errors are often not perceptual misses but interpretive errors driven by faulty reasoning [2,3]. These biases include Anchoring Bias, where a radiologist becomes fixated on an initial impression despite contradictory evidence, often coupled with Confirmation Bias, the inclination to seek information only to affirm that initial theory [2,4,5]. Similarly, Availability Bias, or availability heuristics, predisposes the interpreter to recall recently seen or memorable diagnoses regardless of the actual prevalence [3,4,6]. When AI learns its "concepts" or "relationships" from millions of reports generated under the influence of these specific biases, it may normalize or amplify flawed reasoning patterns, potentially leading to widespread, systemic diagnostic vulnerabilities that mirror rather than correct human limitations [3]. For instance, an AI trained primarily on reports that exhibit Zebra Retreat—the avoidance of accurate but rare diagnoses due to lack of confidence—will systematically underreport uncommon but critical findings, reducing the diagnostic sensitivity for edge cases [2,6]. The core strength of future AI systems must therefore lie not just in conceptual depth but in active debiasing, mitigating the human errors that underpin the training corpus [4,5]. If AI recommendations are opaque, clinicians may fall prey to Blind Obedience or Premature Closure by accepting the machine's initial diagnosis without critical Type 2 analysis [2,6]. To counter this, AI must incorporate the same cognitive forcing strategies used by human interpreters, demanding metacognition ("thinking about thinking") to identify susceptibility to bias [3,4]. Furthermore, AI must specifically address the Hindsight Bias that plagues retrospective quality review [2,6], by ensuring its decision pathways are fully auditable and transparent, allowing for objective assessment of whether an error resulted from inherent data contamination or algorithmic failure. As AI integrates deeper into clinical workflows, its ability to enhance safety hinges on proactively resisting the transfer and propagation of predictable human cognitive limitations [6]. References 1. Merchant SA, Merchant N, Varghese SL, Shaikh MJS. Large language models and large concept models in radiology: Present challenges, future directions, and critical perspectives. World J Radiol. 2025;17(11):114754. [DOI: 10.4329/wjr.v17.i11.114754] 2. Onder O, Yarasir Y, Azizova A, Durhan G, Onur MR, Ariyurek OM. Errors, discrepancies and underlying bias in radiology with case examples: a pictorial review. Insights Imaging. 2021;12:51. [PMID: 33877458. DOI: 10.1186/s13244-021-00986-8] 3. Chen J, Gandomkar Z, Reed WM. Investigating the impact of cognitive biases in radiologists' image interpretation: A scoping review. Eur J Radiol. 2023;166:111013. [PMID: 37541180. DOI: 10.1016/j.ejrad.2023.111013] 4. Busby LP, Courtier JL, Glastonbury CM. Bias in Radiology: The How and Why of Misses and Misinterpretations. Radiographics. 2018;38:236–247. [PMID: 29194009. DOI: 10.1148/rg.2018170107] 5. Gunderman RB. Biases in radiologic reasoning. AJR Am J Roentgenol. 2009;192:561–564. [PMID: 19234247. DOI: 10.2214/AJR.08.1220] 6. Yoon SY, Lee KS, Bezuidenhout AF, Kruskal JB. Spectrum of Cognitive Biases in Diagnostic Radiology. Radiographics. 2024;44:e230059. [PMID: 38843094. DOI: 10.1148/rg.230059] "
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Merchant SA, Merchant N, Varghese SL, Shaikh MJS. Large language models and large concept models in radiology: Present challenges, future directions, and critical perspectives. World J Radiol 2025; 17(11): 114754
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