Publisher Login
Manuscript Statistics
1
2
3
4
5
2025-11-19 | Browse: 3 | Download: 0
6
7
2025-11-19 | Browse: 6 | Download: 0
8
9
10
11
12
13
2025-11-19 | Browse: 10 | Download: 0
14
2025-11-19 | Browse: 25 | Download: 0
15
16
17
18
19
20
825 items Read more >>
1
"We are very satisfied with the entire process since submission to publication in World Journal of Transplantation. We would just like ..."
[Read more]
"We are very satisfied with the entire process since submission to publication in World Journal of Transplantation. We would just like to point out that the process has been a bit long and it would be desirable for it to be a little shorter, although the experience has been satisfactory. "
[Collapse]
Muñoz-Serrano A, Citores MJ, Gutiérrez-Villanueva A, Moreno-Torres V, López-Ibor JV, Vicente N, Cuervas-Mons V. Chronic kidney disease at one year after liver transplantation: Role of changes in immunosuppression over three decades. World J Transplant 2025; 15(4): 108791
2
"We are very pleased with the submission and publication process. The editorial communication was clear and timely, and the reviewers ..."
[Read more]
"We are very pleased with the submission and publication process. The editorial communication was clear and timely, and the reviewers provided constructive and relevant feedback. The overall workflow was efficient and professional. We appreciate the support provided throughout and look forward to the possibility of submitting our work to this journal again in the future. "
[Collapse]
Cheng H, Xia L, Yang HZ, Wei ZX, Zhang YT, Yang J. Role of advanced heart failure and transplant teams in extracorporeal membrane oxygenation management. World J Transplant 2025; 15(4): 108736
3
"We are happy with the submission. I hope that y the editor can provide us with additional invited papers. We look forward to working ..."
[Read more]
"We are happy with the submission. I hope that y the editor can provide us with additional invited papers. We look forward to working with BPG. The reviewing process needs work. It takes numerous months before reviewers are found. The system could be improved by slimlining the entire submission process. Other journals take 1-2 for complete publication. "
[Collapse]
Zeppieri M, Miotti G, Grando M. Interpreting the hazard zone: Factor V and lactate as critical indicators in severe early allograft injury. World J Transplant 2025; 15(4): 110310
4
"I am very satisfied with the submission process this time. It would be even better if the layout fee could be cheaper. Also, the time ..."
[Read more]
"I am very satisfied with the submission process this time. It would be even better if the layout fee could be cheaper. Also, the time from receiving the paper to its official publication is a bit long, it would be best if it could be shorter. Besides that, I have no other opinions. "
[Collapse]
Mao HQ, Yu FC, Hu DQ, Zhang LJ. Myc-associated zinc finger protein drives colorectal cancer metastasis through activating ubiquitin like with ring finger protein one. World J Gastrointest Oncol 2025; 17(11): 109481
5
"I am very satisfied with all aspects, including the submission of the manuscript (the process is simple and easy to understand), peer ..."
[Read more]
"I am very satisfied with all aspects, including the submission of the manuscript (the process is simple and easy to understand), peer review (which takes a short time), revision suggestions (which are highly targeted and professional and have great guiding significance), correction and verification. It will be strongly recommended to colleagues. "
[Collapse]
Pan ZL, Li MQ, Zhang J, Xue LY, Shi YP. Correlation of gut microbiota metabolite trimethylamine N-oxide with inflammatory levels and osteoporosis in patients with diabetic nephropathy. World J Diabetes 2025; 16(11): 109919
6
"We wish to extend our utmost gratitude to the editorial board of the World Journal of Psychiatry for the exemplary management of our ..."
[Read more]
"We wish to extend our utmost gratitude to the editorial board of the World Journal of Psychiatry for the exemplary management of our submission. The journey from initial manuscript submission through to the final decision was remarkably smooth, characterized by clarity and strong editorial support. We found the reviewers' feedback to be exceptionally thought-provoking and practical, which was instrumental in refining and strengthening our paper. Our appreciation also goes to the editors for their careful attention to detail and maintaining a consistently rapid communication flow. Publishing our work with the World Journal of Psychiatry has been an excellent experience, and we eagerly anticipate the opportunity to partner again in the future. "
[Collapse]
Altınöz ŞT, Tarlacık LD, Engin E, Uzel Y, Doğan U, Altınöz AE. Unraveling the role of dysfunctional sleep beliefs: How chronotype shapes sleep quality and academic success in medical students. World J Psychiatry 2025; 15(11): 109566
7
"It is with the utmost honor and immense pride that we present this edition of World Journal of Psychiatry. To be a part of the esteemed ..."
[Read more]
"It is with the utmost honor and immense pride that we present this edition of World Journal of Psychiatry. To be a part of the esteemed conversation within our industry is a privilege we hold dear. This publication stands as a testament to the power of great ideas, and we are deeply grateful to our contributors and readers for making it a vibrant platform for excellence and innovation. "
[Collapse]
Lang XL, Huang CC, Cui HY, Zhong HX, Shen MY, Zhao F. From physiology to psychology: An integrative review of menopausal syndrome. World J Psychiatry 2025; 15(11): 108713
8
"I want to express my appreciate, It truely is such an honor to have this wonderful chance to published our work on prestigious World ..."
[Read more]
"I want to express my appreciate, It truely is such an honor to have this wonderful chance to published our work on prestigious World Journal of Orthpedics. I hope there will be more opportunity to submitt our research to World Journal of Orthpedics. The experience of the manuscript submit and revision reflects the profession and responsibility of this prestigious journal and the respect to the authors. In summary it is a very comfortable and enjoyable process, thank you! "
[Collapse]
Chen YF, Ning K, Xie YY, Liu C, Ding YT, Tang ZW, Wen J, Xiao S, Li YF. Internal diseases and molecular mechanisms causing slipped capital femoral epiphysis in children. World J Orthop 2025; 16(11): 110155
9
"The editorial and production workflow was very smooth. The communication from the assistant editor and language editing team was timely ..."
[Read more]
"The editorial and production workflow was very smooth. The communication from the assistant editor and language editing team was timely and clear, and the peer-review comments were constructive and helpful for improving the quality of the manuscript. I appreciate the professionalism and responsiveness throughout the publication process. Thank you for the support in bringing this work to publication. "
[Collapse]
Cai J, Lu YB, Lv Y, Zhan XJ, Li T, Yang G, Ma YT, Ren JZ, Li B, Yu H, Liao SH, Guo YT, Qiu QP, Hong XP, Huang LB, Zhang Y, Huang SL. Reduced recurrence rate with a targeted approach in uncomplicated appendicitis treated with endoscopic direct vs retrograde therapy. World J Gastroenterol 2025; 31(42): 112106
10
"The publishing system was a very thorough process, with very strict norms and rules, with the goal to obtain the most qualitative ..."
[Read more]
"The publishing system was a very thorough process, with very strict norms and rules, with the goal to obtain the most qualitative result. We appreciate the common effort of the editorial team towards publishing a high standard article. While it has not been easy to comply with the rigours of the publishing, we are glad to have been given the opportunity for such experience. "
[Collapse]
Mănuc M, Duței CA, Mănuc TE, Chifulescu AE, Grama FA. Could artificial intelligence-powered colonoscopies change the future of colorectal cancer screening? World J Gastroenterol 2025; 31(42): 111291
11
"The entire review process of the journal is objective and fair. The communication with the editor is timely and effective.And the ..."
[Read more]
"The entire review process of the journal is objective and fair. The communication with the editor is timely and effective.And the reviewers' comments are professional and helpful. There are quite a few documents and materials needed for submission, so an appropriate longer time for revision of the article can be given. "
[Collapse]
Shi Y, Zhang Y, Zhou AD, Zou HY, Wang MM, Xu F, Cai MY. Association between circulating sex hormone levels and diabetic kidney disease in men and postmenopausal women with type 2 diabetes mellitus. World J Diabetes 2025; 16(11): 111366
12
"Dear Editorial Office, Thank you very much for the professional handling and publication of my manuscript. Overall, I am very satisfied ..."
[Read more]
"Dear Editorial Office, Thank you very much for the professional handling and publication of my manuscript. Overall, I am very satisfied with the review and editorial process. My only suggestion is regarding the initial submission guidelines. The requirements for preparing the first draft—especially details such as formatting and font specifications—were somewhat unclear and difficult to locate within the submission instructions. Clarifying or consolidating these guidelines in a more straightforward manner would greatly help authors ensure full compliance from the beginning and improve the overall submission experience. Thank you again for your excellent work and support. Best regards, "
[Collapse]
Lin L, Zhang P, Wang YY, Cai YF, Wen LB, Chen WP, Xiao YF, Li ZK, Liu GY. Early vs conventional initiation of adjuvant chemotherapy in advanced gastric cancer: A propensity-matched outcomes study. World J Gastroenterol 2025; 31(42): 110069
13
"I found the submission process systematic but bit cumbersome specially the reference submission which could have been made easier ..."
[Read more]
"I found the submission process systematic but bit cumbersome specially the reference submission which could have been made easier with some place for manual editing as well. The peer review quality was very good and that explains the high academic quality of the journal. However, I think instead of sending repeated mails about peer review process, only one mail compiling all reviewers' comments and editorial comments in one final mail. "
[Collapse]
Basu R, Bera S, Mondal S, Shah S, Swapnil K, Nanda R, Datta J, Mandal S, Goswami S, Baidya A, Sengupta N. Deficiency of anterior pituitary hormones in Noonan syndrome and its impact on response to growth hormone therapy. World J Clin Pediatr 2025; 14(4): 108897
14
"I’m highly satisfied with World Journal of Gastroenterology (WJG). As a gastroenterology researcher, its 2.3-month peer review ..."
[Read more]
"I’m highly satisfied with World Journal of Gastroenterology (WJG). As a gastroenterology researcher, its 2.3-month peer review (matching its ~2.4-month average) impressed me. The editorial team was professional and responsive; reviewers offered targeted, constructive comments that boosted my study’s rigor. WJG’s ~85% acceptance rate maintained academic standards, with strict checks on scientific validity and innovation. It focuses on China-specific GI issues (e.g., high-incidence digestive tumors) and supports domestic scholars, serving as a top regional research platform. English polishing certification ensured language accuracy and international impact. WJG is reliable, efficient, and scholar-friendly—I strongly recommend it to gastroenterology researchers, especially those needing timely high-quality publication. "
[Collapse]
Yang Y, Chen WM. RGS4 in gastric cancer: A multifaceted regulator of focal-adhesion-kinase -phosphatidyl-inositol-3-kinase - protein-kinase-B signaling and epithelial-mesenchymal transition beyond tumor progression. World J Gastroenterol 2025; 31(41): 112642
15
"We would like to express our gratitude to the World Journal of Orthopedics for their support throughout our journey in publishing ..."
[Read more]
"We would like to express our gratitude to the World Journal of Orthopedics for their support throughout our journey in publishing the article ‘Correlation of Magnetic Resonance Imaging Biomarkers (Tissue Bridges) with Neurological Recovery Following Traumatic Spinal Cord Injury.’ The submission, peer review, and publication process has been both rigorous and rewarding. "
[Collapse]
Singh R, Gautam S, Aggarwal S, Kaur S, Jain M. Correlation of magnetic resonance imaging biomarkers (tissue bridges) with neurological recovery following traumatic spinal cord injury. World J Orthop 2025; 16(11): 110426
16
"The whole review process was very satisfactory to my team. I appreciate the publishing team for all their efforts. The process was ..."
[Read more]
"The whole review process was very satisfactory to my team. I appreciate the publishing team for all their efforts. The process was very smooth, fast, transparent and scientific. It helped me a lot in improving my manuscript and I learnt a lot during this short and fruitful journey. I will refer this journal and this publishing house to my colleagues for submission of their manuscripts. My sincere regards. "
[Collapse]
Agrawal H, Agarwal N, Gupta N. Impact of gut microbiome on outcomes following endoscopic interventions in gastrointestinal disease. World J Gastrointest Endosc 2025; 17(11): 110207
17
"I am thoroughly pleased with the publication process of my article. The peer-review process was exceptionally rigorous and ..."
[Read more]
"I am thoroughly pleased with the publication process of my article. The peer-review process was exceptionally rigorous and constructive. The reviewers' insightful feedback significantly strengthened the manuscript. Furthermore, the editorial team was incredibly supportive, professional, and efficient throughout. My sincere thanks to everyone involved for their dedication and hard work. "
[Collapse]
Xu K, Wu DH, Zeng CJ, Guo JY, Xi DY, Wang MJ, Yao ZY, Feng AQ, Ji F, Yan XB, Ye LL, Li CY. Clinical predictors of multidrug-resistant Gram-negative pyogenic liver abscess and nomogram construction: A retrospective analysis. World J Gastroenterol 2025; 31(42): 112478
18
"As both an author and a reviewer for World Journal of Diabetes, I am very grateful for the efficient editorial process and professional ..."
[Read more]
"As both an author and a reviewer for World Journal of Diabetes, I am very grateful for the efficient editorial process and professional communication. I have two very small, personal suggestions that you may consider for future development of the journal: 1. Website internationalization: To further enhance the journal’s international visibility and accessibility for non-Chinese readers, you might consider moving towards a fully English user interface (or an easily switchable full-English version) for the journal website. I believe this would make it even more convenient for international authors, reviewers, and readers to navigate and submit manuscripts. 2. Print layout and visual style (purely aesthetic): From a purely personal and aesthetic point of view, the printed layout could perhaps be made a bit more “minimalist” and academic in style. For example, slightly reducing the use of large areas of bright orange-red tones and making the “WJD” journal label a little smaller might give the printed pages a more understated and refined appearance, while still preserving the journal’s visual identity. These are only minor, personal suggestions. Overall, I am very satisfied with my publishing experience with WJD and sincerely appreciate the efforts of the editorial and production team. "
[Collapse]
Guo YL, Niu WJ, Jiao HR, Li YP, Xu C, Zhou X, Wang J. Crosstalk between oxidative stress and inflammatory pathways: Natural therapeutic approaches for diabetic wound healing. World J Diabetes 2025; 16(11): 111400
19
"I am extremely satisfied with the entire submission process of my recent manuscript to World Journal of Gastrointestinal Endoscopy. ..."
[Read more]
"I am extremely satisfied with the entire submission process of my recent manuscript to World Journal of Gastrointestinal Endoscopy. From the initial online submission to the prompt peer review feedback, and from the careful editorial revisions to the smooth final publication, every step was handled professionally, efficiently, and transparently. The editors and reviewers provided valuable, constructive comments that not only improved the quality of my paper but also deepened my understanding of the research field. I sincerely wish your journal continued success and further development, with its SCI impact factor rising steadily to attract more high-quality research from global scholars. I have already recommended your journal to several of my colleagues due to my positive experience, and I eagerly look forward to submitting my future research findings to your journal, hoping they will be favorably received and published. Thank you again for the excellent service and support throughout the process! "
[Collapse]
Li F, Xie YL, Xu D, Lu CH, Wu JW, Ma JX, Guan GX, Wang HX. Comparison of different anastomosis methods in laparoscopically assisted left hemicolectomy for colon cancer. World J Gastrointest Endosc 2025; 17(11): 111117
20
"We would like to express our sincere gratitude to the editor and reviewers for their valuable comments and constructive feedback ..."
[Read more]
"We would like to express our sincere gratitude to the editor and reviewers for their valuable comments and constructive feedback throughout the review process. We appreciate the editor’s professional handling and guidance throughout the review process. We truly appreciate the opportunity to publish our work in your esteemed journal. We hope that our findings will contribute to further discussions and future developments in this research area. Sincerely, Shoko Sagawa "
[Collapse]
Sagawa S, Ito F, Nakatani M, Kurose S, Niiro E, Taniguchi M, Toyoda S, Sado T, Morita K. Mesonephric-like adenocarcinoma presenting with malignant peritonitis and suspected to originate from the fallopian tube: A case report. World J Clin Cases 2025; 13(32): 110813
19950 items Read more >>
1
"A concise, comprehensive, complex and well-structured manuscript. There are no grammatical/spelling errors throughout the manuscript ..."
[Read more]
"A concise, comprehensive, complex and well-structured manuscript. There are no grammatical/spelling errors throughout the manuscript and the topic debated is of a great interest due to the fact that AI technologies have a real potential to revolutionize liver lesion assessment in association with CEUS. Indeed, in order to obtain a valid implementation in clinical practice of AI technologies combined with CEUS, we need more large-scale prospective studies in the near future.
"
[Collapse]
Ciocalteu A, Urhut CM, Streba CT, Kamal A, Mamuleanu M, Sandulescu LD. Artificial intelligence in contrast enhanced ultrasound: A new era for liver lesion assessment. World J Gastroenterol 2025; 31(42): 112196
2
"1 Ethics: Not provided
2 Methods: The experimental method is effective and can be repeated by fellow researchers
3 Results ..."
[Read more]
"1 Ethics: Not provided
2 Methods: The experimental method is effective and can be repeated by fellow researchers
3 Results The theory is validated
4 No figures or tables provided
5 Biostatistics: Not needed
6 References: The author scientifically and reasonably cite the latest references
7 Language: The language in article correctly, clearly and concisely expresses the information
"
[Collapse]
Sameer M, Muthu S, Vadranapu S. Prophylactic fixation in elderly fractures: Preventive breakthrough or unnecessary intervention? World J Orthop 2025; 16(11): 109855
3
"In the recent years,the relationship between intestinal flora disorders and various diseasess,especially IBD,has become clear, and ..."
[Read more]
"In the recent years,the relationship between intestinal flora disorders and various diseasess,especially IBD,has become clear, and fecal transplantation , which aims to improve dysbiosis, has attracted attention.This study also reports on fecal transplantation for the purpose of correcting intestinal flora disorders in IBD,and further research and clinical application are expected in the furture."
[Collapse]
Zheng L, Duan SL, Wang K. Research progress concerning the involvement of the intestinal microbiota in the occurrence and development of inflammatory bowel disease. World J Gastroenterol 2025; 31(42): 113170
4
"It was with pleasure that I reviewed the article quality of the following manuscript. Please see my comments below:
1 Ethics: ..."
[Read more]
"It was with pleasure that I reviewed the article quality of the following manuscript. Please see my comments below:
1 Ethics: Not applicable given manuscript type
2 Methods: Not applicable given manuscript type
3 Results: Not applicable given manuscript type
4 Figures and tables: The tables add to the readability of the manuscript
5 Biostatistics: Not applicable given manuscript type
6 References: References are appropriate/up to date
7 Language: This is a concise/well written manuscript
8 Caveats or drawbacks: None "
[Collapse]
Wang XY, An F, Wang BJ, Han WW. Hydrogen peroxide pathway in ulcerative colitis: Promises and challenges in translating novel pathogenesis to clinical practice. World J Gastroenterol 2025; 31(42): 112566
5
"Overall Assessment
1. The letter clearly addresses the association between BMI and clinical outcomes in ALF, which is clinically ..."
[Read more]
"Overall Assessment
1. The letter clearly addresses the association between BMI and clinical outcomes in ALF, which is clinically relevant.
2. The format follows standard Letter to the Editor conventions, making it easy to read.
3. The discussion is well-supported by Krishnan et al.’s recent study and previous reports (Kanda et al., Rutherford et al.), with accurate citations.
Strengths
1. Highlights a growing concern—obesity and its impact on ALF outcomes.
2. Includes Japanese and U.S. data, showing differences in etiology (acetaminophen vs. non-acetaminophen causes).
3. Emphasizes vigilance for renal failure and hepatic encephalopathy in obese ALF patients.
"
[Collapse]
Kanda T, Sasaki-Tanaka R, Kamimura H, Terai S. Is higher body mass index correlated with worse clinical outcomes in acute liver failure? World J Clin Cases 2025; 13(32): 113514
6
"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..."
[Read more]
"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
[Collapse]
Kim N, Lee H, Park D. Challenging diagnosis of groove pancreatitis with severe gastric outlet obstruction: A case report. World J Clin Cases 2025; 13(32): 111796
7
"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..."
[Read more]
"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
[Collapse]
Aisikaer A, Sun MM, Shen J. Positron emission tomography/computed tomography in risk-factor-negative young female with malignant pleural mesothelioma: A case report and review of literature. World J Clin Cases 2025; 13(32): 110897
8
"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..."
[Read more]
"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
[Collapse]
Liu KT, Lee MH, Lin CH, Tsou YK, Sung KF, Wang SF, Wu CH, Liu NJ. Acute cholangitis due to common bile duct stones: Clinical outcomes in patients with and without concurrent acute pancreatitis. World J Clin Cases 2025; 13(32): 110553
9
"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..."
[Read more]
"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
[Collapse]
Noh BG, Seo HI, Park YM, Oh MH, Song SB. Clinicopathologic differences before and after elective laparoscopic cholecystectomy according to obesity. World J Clin Cases 2025; 13(32): 110391
10
"Has authors used low threshold for BMI in this study.This needs attention and could be bias.To apply this , international definition ..."
[Read more]
"Has authors used low threshold for BMI in this study.This needs attention and could be bias.To apply this , international definition for obesity needs to be included.The study is read by clinicians all over world ans using nonstandardised definition needs to reconsider.
sing a standardized 3-port LC technique.
Using 3 port instead of 4 port in obesity raises alarm over safety keepi in view ergonomics
Intraoperative bile leak in your series seems to be heroic by using 3 port lap chole
"
[Collapse]
Noh BG, Seo HI, Park YM, Oh MH, Song SB. Clinicopathologic differences before and after elective laparoscopic cholecystectomy according to obesity. World J Clin Cases 2025; 13(32): 110391
11
"This case report is highlighting low threshold of Malignancy in groove pancreatitis.A meticolous clinical approach is refeclting in ..."
[Read more]
"This case report is highlighting low threshold of Malignancy in groove pancreatitis.A meticolous clinical approach is refeclting in this case.Imaging is well giving learning .
Introduction is well evidence based.Case presentation is excellent.Discussion is robust with well coverage of latest updates in literaure.References are latest one
Overall, a case report giving good "Message to take home "
"
[Collapse]
Kim N, Lee H, Park D. Challenging diagnosis of groove pancreatitis with severe gastric outlet obstruction: A case report. World J Clin Cases 2025; 13(32): 111796
12
"1. The review provides a thorough and well-organized synthesis of the complex interplay between MASLD and IBD, with a strong emphasis ..."
[Read more]
"1. The review provides a thorough and well-organized synthesis of the complex interplay between MASLD and IBD, with a strong emphasis on the gut microbiota and the gut-liver axis. The topic is highly relevant, given the rising global prevalence of both MASLD and IBD, and the growing recognition of their co-occurrence. The review successfully highlights the shift from a purely metabolic understanding of MASLD to one that incorporates gut-derived inflammation and dysbiosis, which is a crucial contemporary concept.
2. References：The authors have done an excellent job integrating a vast body of literature, making the manuscript a valuable and up-to-date resource for researchers and clinicians.
3. Language：The manuscript is generally well-written in clear and accessible English, which facilitates the comprehension of complex pathophysiological concepts.
4. Figures and tables：A significant shortcoming is the lack of detailed, mechanistic figures. The existing two figures are overly simplistic and do not adequately illustrate the complex molecular and cellular pathways discussed in the text (e.g., the roles of TLRs, bile acid receptors FXR/TGR5, Th17/Treg imbalance, cytokine networks, and the impact of specific microbial metabolites). I strongly recommend the inclusion of at least one high-quality, multi-panel schematic diagram that visually integrates the key proposed mechanisms linking gut dysbiosis, intestinal barrier dysfunction, immune activation, and hepatic inflammation/fibrosis in the context of IBD-associated MASLD.
5. Caveats or drawbacks：
The manuscript contains several typographical and terminological errors that detract from its professionalism. For instance: On Page 4, the text reads "T17 cells play a key role..." This should be corrected to "Th17 cells..." as this is the standard nomenclature for T-helper 17 cells.
While the content is comprehensive, there is some repetition between sections, particularly regarding the description of gut dysbiosis and its consequences in both IBD and MASLD. The flow could be improved by more sharply differentiating the disease-specific mechanisms before synthesizing them into a unified model. The sections on "Eating Behaviour Patterns" and "Nutrition-Microbiota Axis," while interesting, feel somewhat distinct from the core mechanistic focus and could be more seamlessly integrated.
The treatment section briefly mentions probiotics, synbiotics, and cytokine inhibitors (IL-17/IL-23) but lacks depth in discussing the current evidence base, challenges, and future directions for these interventions.
The review excellently describes associations but could more explicitly acknowledge the challenges in establishing causality within the gut-liver axis in human studies.
In summary, this is a timely, informative, and largely well-executed review that makes a valuable contribution to the literature. Its primary strengths lie in its scholarly comprehensiveness and relevance.
"
[Collapse]
Sokal-Dembowska A, Ergan K, Jarmakiewicz-Czaja S. Role of gut microbiota in the development of metabolic dysfunction-associated steatotic liver disease in inflammatory bowel disease. World J Gastroenterol 2025; 31(40): 111375
13
"It is generally accepted that IBD results from the interaction of multiple environmental factors in genetically predisposed ..."
[Read more]
"It is generally accepted that IBD results from the interaction of multiple environmental factors in genetically predisposed individuals, and that altered intestinal permeability is a key mechanism in the pathogenesis of the disease, as in many other digestive tract pathologies. Mitochondrial dysfunction in the intestinal mucosa is another mechanism involved in the pathogenesis of IBD.
In the reviewed study, the authors examined the factor GDF15, a member of the TGF-β superfamily, as a biomarker of mitochondrial dysfunction and a mediator of UPRmt. The researchers confirmed elevated circulating GDF15 levels in IBD patients compared with healthy controls and identified a novel molecular mechanism by which this cytokine disrupts the intestinal barrier. Therefore, successfully reducing GDF15 may constitute a therapeutic strategy to prevent intestinal barrier breakdown by reducing immune hyperactivation in the future.
All these basic research studies contribute decisively not only to elucidating the pathogenetic mechanisms of IBD but also to developing new therapeutic strategies that bring us closer to the day when we can achieve complete and sustained inhibition of IBD activity."
[Collapse]
Ruiz-Malagón AJ, Herraiz-Vilela M, Serrano-Pino R, García-Ávila P, Díaz- Suárez L, Carmona-Segovia AD, Becerra-Munoz VM, Jiménez-Navarro M, Arranz-Salas I, López-Villodres JA, Fernández-Castañer A, Gutiérrez-Martínez F, Rodríguez-González FJ, Camargo-Camero R, Alcaín-Martínez G, Rodríguez-Díaz C, García-Fuentes E, Sánchez-Quintero MJ, López-Gómez C. Growth differentiation factor 15 alters intestinal barrier and increases permeability: A new molecular target in inflammatory bowel disease. World J Gastroenterol 2025; 31(41): 110955
14
"a fine-needle aspiration (FNA) biopsy, especially one guided by endoscopic ultrasound (EUS-FNA), is a valuable diagnostic tool for ..."
[Read more]
"a fine-needle aspiration (FNA) biopsy, especially one guided by endoscopic ultrasound (EUS-FNA), is a valuable diagnostic tool for pancreatic tuberculosis. This procedure allows doctors to collect tissue samples to confirm the diagnosis by checking for characteristic signs like granulomas, caseous necrosis, and acid-fast bacilli (AFB) or by using polymerase chain reaction (PCR) to detect the DNA of Mycobacterium tuberculosis. EUS-FNA is especially useful because it can help differentiate pancreatic TB from pancreatic cancer, preventing unnecessary surgery. "
[Collapse]
Nima CL, Wang HG, Zhou Q. Pancreatic tuberculosis: A case report and review of literature. World J Gastroenterol 2025; 31(41): 110398
15
"In this mini-review, the authors described the current understanding of the pathogenesis, diagnosis, and management of hepatic ..."
[Read more]
"In this mini-review, the authors described the current understanding of the pathogenesis, diagnosis, and management of hepatic hydrothorax. Despite the successes of modern hepatology, the presence of hepatic hydrothorax is associated with poor prognosis and high mortality. Most patients with hepatic hydrothorax are candidates for liver transplantation. In usual clinical practice, the key to the success of their management may be the stratification of the risk of an adverse outcome and the definition of individual therapeutic tactics. A pathogenetically based approach to the choice of pharmacotherapy, as well as optimization of minimally invasive treatment methods, will improve the quality of life and increase the survival rate of this category of patients. In general, the authors provided well-known information."
[Collapse]
Cilia BJ, Haridy J, Raj A, Hannah N. Hepatic hydrothorax as a manifestation of decompensated cirrhosis: An update on current management and future directions. World J Hepatol 2025; 17(10): 110412
16
"Dear Author
There are parameters like MELD score that show the severity of the disease. This important score was not addressed ..."
[Read more]
"Dear Author
There are parameters like MELD score that show the severity of the disease. This important score was not addressed in the trial. Were the adherent and non-adherent groups had similar MELD scores? Sarcopenia as another important factor that influence cirrhosis out comes. This risk factor was not addressed in this trial. The nutritional status regarding the vitamins and protein intake are among the most important factors that influence cirrhosis out comes. In the future trials considering the variables that influence the patient outcomes should be considered. "
[Collapse]
Loschi TM, Baccan MDTA, Pereira EC, Dellabarba TDLC, Boteon APCS, Boteon YL. Telerehabilitation for frail cirrhotic patients awaiting liver transplant: A safe, effective strategy to improve outcomes. World J Hepatol 2025; 17(10): 110856
17
"Dear Author,
The patient had a history of cirrhosis of the liver based on abdominal CT scan. The data regarding the other causes ..."
[Read more]
"Dear Author,
The patient had a history of cirrhosis of the liver based on abdominal CT scan. The data regarding the other causes of chronic hepatitis were not included in the draft. Although using herbal medicine could cause the fulminant hepatitis, yet it is a diagnosis of exclusion. In my opinion, the possibility of coexistence of auto immune hepatitis in this case needs more evaluation."
[Collapse]
Zhu XY, Zhao YT, Su CS, Yuan XD, Zhang SG, Nashan B. Acute liver failure caused by alkaloids from traditional Chinese medicine: A case report. World J Hepatol 2025; 17(10): 109575
18
"In recent years, artificial intelligence (AI) has brought about a real revolution in various fields of human activity, establishing ..."
[Read more]
"In recent years, artificial intelligence (AI) has brought about a real revolution in various fields of human activity, establishing itself as a pioneering innovation in modern medical science. In the field of gastroenterology, and in particular colonoscopy, it has contributed significantly by promoting key quality indicators, reducing the rate of human error, and improving the consistency of endoscopist decision-making with high reliability. Reduce human error and improve endoscopists' decision-making consistency in real time, ensuring higher reliability and standardization during the procedure. By optimizing the characterization of endoscopically detected lesions, supporting visual diagnosis, and predicting the depth of infiltration, AI can enable early diagnosis and prevention of colon cancer. The combination of AI with advanced imaging techniques improves the quality of gastroenterologists' training.
However, much remains to be clarified regarding the role of AI in upper and lower gastrointestinal endoscopy. I believe that the official gastroenterological societies of Europe, the USA, and Asia should immediately delve into studying and defining the possibilities, potential risks of the widespread application of the method, and define policies regarding quality assurance, clinician education, data protection, and liability, so that AI successfully complements human intelligence and experience. The innate tendency of people (in this case, endoscopists) to resist adopting these new technologies should not prevail. They can also help validate AI systems in real-world conditions by assessing their performance across a wide range of quality indicators.
I want to congratulate the authors for their excellent work in a promising field."
[Collapse]
Dimopoulou K, Spinou M, Ioannou A, Nakou E, Zormpas P, Tribonias G. Artificial intelligence in colonoscopy: Enhancing quality indicators for optimal patient outcomes. World J Gastroenterol 2025; 31(40): 111499
19
"This is very interesting paper.Higher serum gamma-glutamyl transpeptidase (γ-GTP) levels are associated with an increased risk of ..."
[Read more]
"This is very interesting paper.Higher serum gamma-glutamyl transpeptidase (γ-GTP) levels are associated with an increased risk of pancreatic cystic neoplasms (PCNs) and their malignant progression. However, γ-GTP is not a specific diagnostic marker for these conditions. Its elevation is more indicative of general liver or biliary dysfunction and oxidative stress. Recent large-scale studies have found that people with higher baseline serum γ-GTP levels have a significantly increased risk of being diagnosed with PCNs later on. This suggests γ-GTP could potentially serve as a biomarker for identifying high-risk individuals for surveillance."
[Collapse]
Lee MW, Park JM, Cho IR, Chung KH, Kim BS, Choi JH, Paik WH, Ryu JK, Han K, Lee SH. Serum gamma-glutamyl transferase level is associated with the risk of pancreatic cystic neoplasms: A nationwide retrospective cohort study. World J Gastroenterol 2025; 31(40): 110932
20
"Artificial intelligence has brought about a real revolution in various areas of human activities, including medical science. In recent ..."
[Read more]
"Artificial intelligence has brought about a real revolution in various areas of human activities, including medical science. In recent years, AI has also emerged as a method to support the correct diagnosis and treatment of acute pancreatitis. Some elements of AI, such as machine learning, deep learning, natural language processing, and network pharmacology, seem to significantly facilitate diagnostic and therapeutic decisions in the treatment of patients with acute pancreatitis, through the analysis of clinical records, medical images, laboratory values, genomic data, and physiological signals in real time. AI functions as advanced decision support, enhancing clinical judgment with intelligence derived from diagnostic data, assessing risks to the patient from potential complications, and helping safely predict the disease. The authors also discuss future directions for AI development in the treatment of acute pancreatitis. As emphasized by the authors of this review, today's practical medicine often requires an interdisciplinary approach that integrates clinical experience, computational modeling, and ethical design. These largely theoretical data currently have limited application, especially in developing countries worldwide. For all health systems and in any country where AI is applied, its assistance should consist of improving decision-making through hybrid human-artificial intelligence models. The future looks excellent, although it causes concern and fear to the undersigned."
[Collapse]
Zhang XY, Hu MD, Maimaitijiang D, Wang T, Wang L. Artificial intelligence in pancreatitis: A narrative review on advancing precision diagnosis, prognosis, and therapeutic strategies. World J Gastroenterol 2025; 31(39): 110971
15843 items Read more >>
Peer-Reviewers and Manuscript Statistics
- Editorial board members
- 2264
- Peer-reviewers
- 34710
- Manuscripts received today
- 15
- Manuscript reviews today
- 58
- Unhandled manuscripts today
- 135
- Active peer-reviewers today
- 3583
- Reviewer acceptance today
- 66
- Reviewer refusals today
- 100
- Total accepted manuscripts
- 38654
- Total rejected manuscripts
- 43728
- Total peer-reviewers
- 4503897
- Total submissions
- 36671
1
2025-12-20 | Browse: 5449 | Download: 318
2
2025-12-20 | Browse: 5784 | Download: 483
3
4
2025-12-20 | Browse: 4507 | Download: 316
5
2025-12-20 | Browse: 5198 | Download: 357
6
7
8
9
2025-12-20 | Browse: 5256 | Download: 382
10
11
12
2025-12-20 | Browse: 4524 | Download: 384
13
14
15
16
17
2025-12-20 | Browse: 5210 | Download: 357
18
19
20
2025-12-20 | Browse: 4242 | Download: 290
60880 items Read more >>
1
2025-11-19 | Browse: 5 | Download: 52
2
3
4
2025-11-19 | Browse: 2 | Download: 37
5
6
2025-11-17 | Browse: 22 | Download: 64
7
8
9
2025-11-14 | Browse: 41 | Download: 82
10
11
12
13
14
2025-11-14 | Browse: 48 | Download: 46
15
16
17
18
19
20
2025-11-14 | Browse: 38 | Download: 90
10085 items Read more >>
73319 items Read more >>
1
"The study by Li Lin et al., “Early vs conventional initiation of adjuvant chemotherapy in advanced gastric cancer: A ..."
[Read more]
"The study by Li Lin et al., “Early vs conventional initiation of adjuvant chemotherapy in advanced gastric cancer: A propensity-matched outcomes study,” addresses a clinically relevant question; however, several issues limit the strength and applicability of its conclusions. First, the analysis does not demonstrate any clear advantage of early versus conventional initiation of adjuvant chemotherapy in terms of either overall survival or disease-free survival. A possible benefit is suggested with respect to the rate of peritoneal recurrence, but this signal is difficult to interpret in the absence of any comparison with currently available intraperitoneal treatment strategies. Moreover, the study does not provide robust selection criteria to clearly identify which patients might be optimal candidates for an earlier initiation of adjuvant therapy. Given the well-known short-term physiological impact of gastrectomy, there is a concrete risk that patients starting chemotherapy very early after surgery may actually receive a suboptimal treatment—most notably through dose reductions—precisely in the first cycles, when dose intensity may be most critical. Finally, the heterogeneity of the adjuvant chemotherapy regimens, which persists even after propensity score matching, further complicates interpretation of the results and limits the ability to draw firm conclusions regarding the true effect of treatment timing per se. "
[Collapse]
Lin L, Zhang P, Wang YY, Cai YF, Wen LB, Chen WP, Xiao YF, Li ZK, Liu GY. Early vs conventional initiation of adjuvant chemotherapy in advanced gastric cancer: A propensity-matched outcomes study. World J Gastroenterol 2025; 31(42): 110069
2
"Long-term prognosis of HBV-cirrhosis hepatocellular carcinoma recurrence and mortality rates post-treatment with antivirals TDF, TAF, ..."
[Read more]
"Long-term prognosis of HBV-cirrhosis hepatocellular carcinoma recurrence and mortality rates post-treatment with antivirals TDF, TAF, ETV and curative radiofrequency ablation is still controversial Dina Johar* Department of Biochemistry and Nutrition, Faculty of Women for Arts, Sciences and Education, Ain Shams University, Heliopolis, Cairo, Egypt *Dina Johar, PhD Department of Biochemistry and Nutrition Faculty of Women for Arts, Sciences, and Education Ain Shams University, Cairo, Egypt Phone:+2 01060782045 Email: dinajohar@gu.edu.eg • To whom correspondence should be addressed Abstract The efficiency of antiviral agents for hepatitis B cirrhosis-related hepatocellular carcinoma (HCC) is still an important clinical challenge with high recurrence rates. In this commentary, we focus on recent findings from Xu et al. We highlight the potential benefit of studying HBV genotypes and subgenotypes as possible mechanisms behind different responses to antivirals. Mechanisms of viral reactivation that parallel HCC recurrence remain uncovered. The commentary is a significant step forward in understanding the nuanced approach to managing HCC recurrence and mortality rate in HBV-cirrhosis patients, offering valuable insights for clinical decision-making. Keywords HBV-related HCC, TDF, TAF, ETV, recurrence, mortality Core Tip A similar virological response to TDF, TAF, and ETV treatment in the first 6-12 months may require further investigation to understand early treatment dynamics. Understanding how HBV genotypes and subgenotypes influence chronic active HBV infection is crucial. Investigating potential molecular mechanisms that explain recurrence rate differences helps develop predictive models for individualized treatment selection. Background The paper entitled “Effect of antiviral therapy on 3-year recurrence and prognosis of hepatocellular carcinoma after curative radiofrequency ablation” by Xu et al. (1) is a robust retrospective cohort study that comprehensively evaluates long-term prognostic effects of advanced nucleos(t)ide analogs (NAs): ETV, TDF, and TAF on HBV-cirrhosis HCC patients post-RFA outcomes. The study identified four independent predictors of post-RFA HCC recurrence. The study findings recommend TDF or TAF as preferred antiviral agents for the long-term management of such patients. The three antiviral agents had a similar impact on the three-year mortality rate. The study used a substantial sample size (n=319) with a follow-up period of 144 weeks, across multiple time points (6, 12, 24, 36 months), although the sample sizes in the TDF (n=76) and TAF (n=52) groups are relatively small. Two of the major determinants of the outcome of chronic HBV infection are the HBV genotypes and subgenotypes. While Xu et al. adhered to established diagnostic guidelines, there are at least ten different confirmed HBV genotypes (A-J). There is limited knowledge about how different genotypes and subgenotypes of HBV affect the risk of HCC recurrence in patients with HBV-cirrhosis related HCC. The best way to find out is through long-term, population-based studies. These studies should compare people with different genotypes and follow them over time. For example, there is a substantial homogeneity of HBV subtypes found in Egypt, a country with a comparably high HBV-cirrhosis-related HCC, mostly genotype D, subgenotype D3, hepatitis B surface antigen (HBsAg) subtype ayw2, with a prevalence of the Major Hydrophilic Region (MHR) mutations (2). Genotype D is related to more advanced liver disease, i.e., HCC, than other genotypes (3) and is an independent risk for Fulminant Hepatitis (FH) (4). Whether new classes of drugs are needed to manage chronic HBV, whether a cure is possible, or even necessary, has not been addressed. The goal of new therapies for chronic hepatitis B should be to achieve a virological cure. Current NAs can slow down HBV replication and help improve liver damage. However, they rarely fully clear chronic HBV infections. There is an urgent need for new drugs and more effective strategies to combat the virus, which eventually will help get rid of the cancer. Still, more research is needed to find clear links between specific genotypes and risks like cirrhosis or HCC. Some research has been carried out in areas such as Asia and Alaska, but many genotypes, including A1 and D, have not been studied in long-term, prospective research. Data is missing for some genotypes and subgenotypes, such as A3, E, F4, and H, regarding their impact on health. Collaboration between multiple institutions from different countries enhances the strength of these studies. Retrospective and prospective studies examined serum HBV DNA levels, liver function, complication rates, and hospital stay duration (5, 6). A study looked at whether high-dose TDF therapy can stop HBV-related HCC recurrence. They designed a study where everyone received the same treatment, with no comparison group. The goal was to determine if using high-dose TDF is practical in real-world settings. They enrolled 10 patients in September 2015 and monitored their progress for three months or until they had to discontinue treatment early. They found that high doses of TDF, up to five times the recommended amount, are poorly tolerated by many patients. These doses also do not effectively stop HBV from replicating as HCC progresses (7). In 2018, a study looked at 607 patients with HBV-related HCC who had surgery or RFA. They divided them into three groups based on their antiviral drugs. The first group, with 261 patients, did not get antiviral treatment. The second group, with 90 patients, received low-strength NAs. The last group, with 256 patients, was treated with high-strength NAs. The main goal was to see how long patients stayed free of cancer recurrence. Patients on ETV and TDF had fewer recurrences than those on other antivirals (8). Another study followed 1,695 patients who had surgery for HBV-related HCC at Korea’s Barcelona Clinic Liver Cancer stage 0 or A between 2010 and 2018. Of these, 813 patients received ETV while 882 took TDF. The study compared cancer recurrence and overall survival between the two groups, using statistical methods to match patients’ backgrounds and adjust for other confounding factors. The analysis started from the day of their liver surgery. Results showed that patients on TDF had a notably lower chance of their HCC recurrence and survived longer overall than those on ETV (9). Between 2013 and 2017, three hospitals enrolled patients with HBV-related HCC who had surgery or ablation as their first treatment. A 421 patients had part of their liver removed, and 305 received RFA. All of these patients started antiviral medication using either ETV or TDF. The study examined HCC recurrence and mortality rates. Researchers adjusted for factors such as HBV DNA levels, tumour characteristics, and patient demographics. The results showed no significant difference in cancer recurrence or death rates between patients treated with ETV and TDF (10). Patients with HCC who go beyond the Milan criteria tend to have a high chance of HCC recurrence post-surgery. When comparing treatments, TDF significantly reduces the risk of HCC recurrence more than ETV therapy (11). Using propensity score matching from the date of liver resection for HCC, TDF showed better overall survival. It also offered stronger protection of liver function. However, in another study, there was no difference in the rate of HCC recurrence between TDF and ETV treatments (12). Other research shows that TDF works better than ETV for eliminating hepatitis B symptoms after RFA treatment. It helps reduce serum HBV DNA levels and improves the albumin-bilirubin (ALBI) grade more effectively (13) (14). A study in 2024 looked at how TDF and ETV affect long-term health in patients with HCC, fatty liver disease, and HBV. The researchers analyzed patient data using a multivariate Cox proportional hazards model and applied a propensity score matching method. They then compared survival outcomes with Kaplan-Meier survival curves. The results showed that TDF helped improve long-term prognosis for patients (15). The latter discovery was confirmed in 2025 in patients with high HBsAg levels after they had their liver removed (16). A study looked back over ten years, finishing in 2025. It included 1,396 patients with HBV-related cirrhotic HCC who had surgery. The patients were divided into two groups: those who took antiviral medicine and those who did not. The research focused on HCC recurrence, taking into account when the antiviral treatment was started, how well the virus was kept under control, and the levels of HBV DNA. Recurrences were labelled as early if they occurred within two years and late if they occurred after that. The study found that long-term antiviral therapy helped prevent late recurrence after surgery, regardless of whether it was started pre- or post-operation. Patients who responded well to the virus treatment saw the biggest benefit (17). Given such controversial results, in Xu et al. study, being a single-center study, there is potential for selection bias inherent in the retrospective study design. The uneven baseline characteristics across treatment groups, potential need for larger sample size to validate findings, and limited exploration of potential mechanisms are behind the differential recurrence rates achieved with TDF, TAF versus ETV, or even behind the similar impact that the three NAs had on the three-year mortality rate. The study will benefit from extending the follow-up period to provide more comprehensive long-term insights. Considering propensity score matching to reduce potential selection bias. Expanding the research scope through multi-center collaborative study enhances external validity and generalizability. Exploring potential interaction effects between NAs and the molecular mechanisms underlying the differential efficacy of TDF and TAF is insightful. Including more diverse patient populations enhances analytical approach, provides a nuanced understanding of anti-HBV agent effectiveness and contributes to a personalized medicine approach in hepatology. Including sensitivity analyses helps validate findings. Declarations Funding This commentary did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. The author declare that no honorarium, grant, or other form of payment was given to anyone to produce the manuscript. Conflict of interest The author declares no conflict of interest exists. Consent to publish Not applicable. Availability of data and materials All data generated or analyzed during this study are included in this published article. Acknowledgment N/A References 1. Xu B, Zhang X, Liu F, Li F, Zhang X, Xiang H, et al. Effect of antiviral therapy on 3-year recurrence and prognosis of hepatocellular carcinoma after curative radiofrequency ablation. World J Gastrointest Oncol 2025;17: 112689. 2. Abu Zeid WA RD, Shemis MA,. Prevalence of mutations within major hydrophilic region of hepatitis B virus and their correlation with genotypes among chronically infected patients in Egypt. Arab Journal of Gastroenterology 2016 17 (2016) 34–40. 3. Thakur V, Guptan RC, Kazim SN, Malhotra V, SK. S. Profile, spectrum and significance of HBV genotypes in chronic liver disease patients in the Indian subcontinent. . J Gastroenterol Hepatol. 2002;17:165-70. 4. Wai CT, Fontana RJ, Polson J, Hussain M, Shakil AO, Han SH, et al. US Acute Liver Failure Study Group. Clinical outcome and virological characteristics of hepatitis B-related acute liver failure in the United States. J Viral Hepat. 2005 12:192-8. 5. Yuan B, Li R, Yuan W, Xiang B, Zheng M, Yang T, et al. Perioperative entecavir for patients with HBV-related hepatocellular carcinoma and low levels of viral DNA: analysis using propensity score matching. Oncotarget. 2017 16(31):51810-6. 6. Yoo S, Jang J, Kwon J, Jung S, Jang B, Choi J. Preemptive antiviral therapy with entecavir can reduce acute deterioration of hepatic function following transarterial chemoembolization. . Clin Mol Hepatol. 2016 22:458-65. 7. Hwang S, Song G, Jung D, Yoon Y, Yoo H, Tak E. High-dose tenofovir is not effective in suppressing hepatitis B virus replication in patients with hepatocellular carcinoma progression: a preliminary result. Korean J Hepatobiliary Pancreat Surg.2016(1). 8. Cho H, Ahn H, Lee DH, Lee JH, Jung YJ, Chang Y, et al. Entecavir and tenofovir reduce hepatitis B virus-related hepatocellular carcinoma recurrence more effectively than other antivirals. . Journal of viral hepatitis. 2018;25:707–17. 9. Choi J, Jo C, Lim YS. Tenofovir Versus Entecavir on Recurrence of Hepatitis B Virus-Related Hepatocellular Carcinoma After Surgical Resection. Hepatology (Baltimore, Md). 2021 73(661–673). 10. Lee JH, Kim BK, Park SY, Tak WY, Park JY, Kim DY, et al. The efficacies of entecavir and tenofovir in terms of enhancing prognosis after curative treatment of hepatitis B virus-related hepatocellular carcinoma. . Eur J Intern Med.2021:48-55. 11. Shen J, Qi W, Dai J, Leng S, Jiang K, Zhang Y, et al. Tenofovir vs. entecavir on recurrence of hepatitis B virus-related hepatocellular carcinoma beyond Milan criteria after hepatectomy. . Chinese medical journal. 2021;135:301–8. 12. Wang XH, Hu ZL, Fu YZ, Hou JY, Li WX, Zhang YJ, et al. Tenofovir vs. entecavir on prognosis of hepatitis B virus-related hepatocellular carcinoma after curative resection. . Journal of gastroenterology. 2022;57:185–98. 13. Hu Z, Zeng H, Hou J, Wang J, Xu L, Zhang Y, et al. Tenofovir vs. Entecavir on Outcomes of Hepatitis B Virus-Related Hepatocellular Carcinoma after Radiofrequency Ablation. Viruses. 2022;14(656). 14. Giri S, Agrawal D, Afzalpurkar S, Gopan A, Angadi S, Sundaram S. Tenofovir versus entecavir for tertiary prevention of hepatocellular carcinoma in chronic hepatitis B infection after curative therapy: A systematic review and meta-analysis. . Journal of viral hepatitis. 2023;30:108–15. 15. Kong Q GQ, Li W, Chen Z. Effect of tenofovir versus entecavir on the long-term prognosis in hepatocellular carcinoma patients with concurrent metabolic dysfunction-associated steatotic liver disease and hepatitis B. Asian J Surg. 2024 Nov;47(11):4725-4734. doi: 10.1016/j.asjsur.2024.03.147. Epub 2024 Sep 16. PMID: 39289060. 16. Qiu Z XY, Qi W, Shen J, Wen T, Li C. Tenofovir vs Entecavir on the Prognosis of Patients With Hepatitis B Virus-Related Hepatocellular Carcinoma After Liver Resection: The Role of HBsAg Levels. Clin Transl Gastroenterol. 2025 Mar 1;16(3):e00814. doi: 10.14309/ctg.0000000000000814. PMID: 39791573; PMCID: PMC11932590. 17. Liu J BS, Shi X, Yuan T, Yu Y, Lin J, Dai C, Wu Y, Cui L, Zhu B, Fu X, Wang K, Yu W, Li J. Benefits of entecavir therapy in HBV-related hepatocellular carcinoma patients with compensated cirrhosis after hepatectomy: A ten-year retrospective cohort study. Eur J Surg Oncol. 2025 May;51(5):109621. doi: 10.1016/j.ejso.2025.109621. Epub 2025 Jan 23. PMID: 39919509. "
[Collapse]
Xu BG, Zhang X, Liu F, Li FH, Zhang X, Xiang HL, Liang J. Effect of antiviral therapy on 3-year recurrence and prognosis of hepatocellular carcinoma after curative radiofrequency ablation. World J Gastrointest Oncol 2025; 17(11): 112689
3
"This study has provided a combined method including ultrasound and endoscopic examination to present the clinical features of ..."
[Read more]
"This study has provided a combined method including ultrasound and endoscopic examination to present the clinical features of pancreatic cancer in patients with old age. The lifestyles of these patients can be analyzed to perform the potential relationship in the prognosis of pancreatic cancer. In addition, the important features in malignant level as this study displayed may be summarized by author's efforts to indicate significantly and meaningfully in the prognosis of pancreatic cancer in patients. "
[Collapse]
Zignani N, Balzarini M, Dabizzi E, Fracas E, Millefanti L, Segato S, Vecchi M, Cengia G, Missale G, Tontini GE, Moneghini D, Cavallaro F. Endoscopic ultrasound features of pancreatic solid lesions: Descriptive and predictive analysis on a multicenter sample. World J Gastrointest Endosc 2025; 17(11): 112487
4
"The comprehensive review by Professor Elsayed offers a timely and insightful overview of a critical clinical challenge: the management ..."
[Read more]
"The comprehensive review by Professor Elsayed offers a timely and insightful overview of a critical clinical challenge: the management of recurrent hepatocellular carcinoma (RHCC). As a clinician actively managing HCC patients, I find this synthesis of evidence exceptionally valuable. RHCC indeed lacks standardized guidance, and this review effectively consolidates fragmented data across surgical, locoregional, and systemic modalities, offering pragmatic approaches tailored to recurrence patterns (intrahepatic vs. extrahepatic), liver functional reserve, and prior interventions. RHCC complexity demands collaboration between hepatologists, surgeons, interventional radiologists, and oncologists—highlighted here as essential for optimizing outcomes. The candid discussion on limitations—such as the reduced functional liver remnant post-resection/transplant, donor shortages for salvage LT (SLT), and the aggressive biology of RHCC—grounds the review in clinical reality. Coverage of emerging strategies—like combination therapies (TACE + sorafenib), novel ICIs (e.g., atezolizumab/bevacizumab), and AI-driven recurrence prediction—provides hope and direction for ongoing research. While ther are some points for further discussion. In practice, SLT candidates often face adverse factors (e.g., time to recurrence "
[Collapse]
Elsayed MOK. Treatment of recurrent hepatocellular carcinoma: The current standards and future perspectives. World J Gastrointest Oncol 2025; 17(11): 110735
5
"The study provides strong evidence that circulating GDF15 levels are elevated in IBD patients, with a clear correlation to markers ..."
[Read more]
"The study provides strong evidence that circulating GDF15 levels are elevated in IBD patients, with a clear correlation to markers of inflammation and intestinal permeability. This relationship could offer a new avenue for monitoring disease progression and assessing the severity of IBD. The results showing that GDF15 impacts the intestinal barrier function by modulating tight junctions such as ZO-1 and claudin 1 are especially intriguing. From a clinical standpoint, understanding how GDF15 contributes to barrier dysfunction could lead to new therapeutic targets aimed at preventing the "leaky gut" phenomenon, which is a key feature in IBD. One of the most interesting aspects is the suggestion that GDF15 could be a potential biomarker for intestinal permeability, which could be valuable in both clinical diagnosis and disease monitoring. However, as a clinician, I’d like to see more clarity on how these findings might translate into practical treatment strategies. For instance, how could we use this information to develop therapies targeting GDF15 or its signaling pathways in patients with IBD? Additionally, while the in vitro findings are compelling, clinical trials will be essential to confirm whether modulating GDF15 can indeed improve clinical outcomes for IBD patients. "
[Collapse]
Ruiz-Malagón AJ, Herraiz-Vilela M, Serrano-Pino R, García-Ávila P, Díaz- Suárez L, Carmona-Segovia AD, Becerra-Munoz VM, Jiménez-Navarro M, Arranz-Salas I, López-Villodres JA, Fernández-Castañer A, Gutiérrez-Martínez F, Rodríguez-González FJ, Camargo-Camero R, Alcaín-Martínez G, Rodríguez-Díaz C, García-Fuentes E, Sánchez-Quintero MJ, López-Gómez C. Growth differentiation factor 15 alters intestinal barrier and increases permeability: A new molecular target in inflammatory bowel disease. World J Gastroenterol 2025; 31(41): 110955
6
"As a clinician, I found this study highly relevant and practical. The use of VCTE to assess liver fibrosis in PBC patients offers ..."
[Read more]
"As a clinician, I found this study highly relevant and practical. The use of VCTE to assess liver fibrosis in PBC patients offers a non-invasive, reliable alternative to liver biopsies, which is a huge advantage in daily practice. The dual cut-off approach for diagnosing advanced fibrosis seems useful, providing clear thresholds that can guide treatment decisions without the need for invasive procedures. However, the grey area (10-14.5 kPa) remains a challenge, and it would be helpful to have additional tools or markers for better decision-making in these cases. Overall, this study offers a valuable, non-invasive method for fibrosis assessment, but more research on managing patients in the grey zone would be beneficial. "
[Collapse]
Chen JL, Hou YX, Liu Y, Jiang YY, Wang XB. Real-world performance of transient elastography in assessing advanced fibrosis in Chinese patients with primary biliary cholangitis. World J Gastroenterol 2025; 31(41): 111256
7
"Transient Elastography is an easy, bedside, non-invasive test for assessing liver fibrosis. PBC is a condition for which earlier ..."
[Read more]
"Transient Elastography is an easy, bedside, non-invasive test for assessing liver fibrosis. PBC is a condition for which earlier diagnosis and treatment are associated with a better prognosis. So, evaluating Fibrosis has important diagnostic and therapeutic implications in PBC. However, studies on TE in PBC are limited to Asian settings, and the study by Jia-Liang Chen provides important data in this subset. In this retrospective study, they compared TE with the gold-standard findings of liver biopsy. They showed that TE is highly accurate for diagnosing Advanced fibrosis, and LSM has outperformed other fibrotic markers in ROC curves. Furthermore, they have classified patients with LSM into early, indeterminate, and late stages based on the LSM cut-off; these stages may have future prognostic significance. Future Prospective observational studies can be conducted to assess changes in LSM with treatment, disease progression, or complications. "
[Collapse]
Chen JL, Hou YX, Liu Y, Jiang YY, Wang XB. Real-world performance of transient elastography in assessing advanced fibrosis in Chinese patients with primary biliary cholangitis. World J Gastroenterol 2025; 31(41): 111256
8
"The authors presented a case of pancreatic tuberculosis and provided a detailed analysis of the diagnostic process, which holds ..."
[Read more]
"The authors presented a case of pancreatic tuberculosis and provided a detailed analysis of the diagnostic process, which holds significant reference value for the diagnosis of similar cases. However, the report lacks an in-depth discussion and evaluation of the treatment approach and therapeutic strategy employed in this case, thereby limiting its applicability in guiding clinical management of analogous conditions. Consequently, the inclusion of a comprehensive treatment plan would substantially enhance the clinical utility and overall contribution of this case report. "
[Collapse]
Nima CL, Wang HG, Zhou Q. Pancreatic tuberculosis: A case report and review of literature. World J Gastroenterol 2025; 31(41): 110398
9
"This study has compared several computational methods to be used in the predication of prognosis for acute variceal bleeding in ..."
[Read more]
"This study has compared several computational methods to be used in the predication of prognosis for acute variceal bleeding in cirrhosis patients. Author claimed that the convolution network by their efforts displayed the best effect in the outcomes analysis rather than another methods. However, the specific features in different subgroups with data presentations using AI or other computational methods lacked in the full analysis to be performed in the compared computation process. This means that this study only provides the end result for supporting their analysis as they wanted. In addition, the standard between high and low risk group presented to differ significantly without clinical parameters in this study. "
[Collapse]
Xiang Y, Yang N, Zheng TL, Huang YF, Liu TY, Ma DQ, Hu SJ, Zhang WH, Xiang HL, Zhang LY, Yuan LL, Wang X, Dang T, Zhang G, Wu B, Peng LJ, Gao M, Xia DL, Liu ZB, Li J, Song Y, Zhou XQ, Qi XS, Zeng J, Tan XY, Deng MM, Fang HM, Qi SL, He S, He YF, Ye B, Wu W, Shao JB, Wei W, Hu JP, Yong X, He CH, Bao JL, Zhang YN, Ji R, Bo Y, Yan W, Li HJ, Li SL, Geng S, Zhao L, Liu B, Qi XL. Development of a deep learning model for guiding treatment decisions of acute variceal bleeding in patients with cirrhosis. World J Gastroenterol 2025; 31(41): 111361
10
"This article is a well-conducted clinical study that elucidates the psychological profiles of patients undergoing esophagectomy for ..."
[Read more]
"This article is a well-conducted clinical study that elucidates the psychological profiles of patients undergoing esophagectomy for esophageal cancer. Its core contributions lie in: 1. Demonstrating a significant negative correlation among anxiety, depression, and mindfulness, advancing understanding of the mind–body interaction in surgical oncology; 2. Identifying key demographic and clinical risk factors that shape postoperative emotional outcomes, thereby guiding individualized psychological assessment and intervention. By linking psychometric evaluation with perioperative management, this study offers a valuable reference for integrating mindfulness-based strategies into holistic recovery pathways. "
[Collapse]
Deng X, Hu YH, Xiong YJ, Mao N, Hong B, He G. Correlation of anxiety and depression with mindfulness in esophageal cancer patients undergoing esophagectomy and analysis of risk factors. World J Psychiatry 2025; 15(9): 104813
11
"The article is well-written and demonstrates a clear and logical flow from the introduction to the conclusion. The research objectives ..."
[Read more]
"The article is well-written and demonstrates a clear and logical flow from the introduction to the conclusion. The research objectives are clearly stated, and the study design appropriately addresses the research questions. The literature review is comprehensive and up to date, providing a strong theoretical foundation for the study. The methodology is well-described, enabling replication, and the data analysis is appropriate and rigorous. The discussion effectively interprets the findings in relation to existing studies, and the conclusions are supported by the results. Overall, this is a good-quality manuscript that makes a valuable contribution to the field. "
[Collapse]
Yanti L, Surtiningsih, Ardiyani FHN, Sekarini NNAD, Susanti D, Mustaan, Murniati, Supriyadi, Santosa A. Long-term consequences of unintended pregnancy: Impacts on early childhood growth and development in a multicenter study. World J Clin Pediatr 2025; 14(4): 107346
12
"The retrospective study by Huang and colleagues provides valuable insights into the prevalence and clinicopathological significance ..."
[Read more]
"The retrospective study by Huang and colleagues provides valuable insights into the prevalence and clinicopathological significance of HER2 expression in upper tract urothelial carcinoma. Their finding that HER2 overexpression is strongly associated with high tumor grade but not with conventional markers of disease progression underscores the distinct biological behavior of UTUC compared to bladder cancer. This work is particularly relevant as it highlights a potential therapeutic target in a disease with limited treatment options. However, the clinical implications of HER2 expression in UTUC must now be reinterpreted in light of the practice changing results presented at the ESMO Congress 2025. The phase 3 RC48 C016 trial demonstrated for the first time that a combination of the anti HER2 antibody drug conjugate disitamab vedotin and the anti PD1 immunotherapy toripalimab significantly outperforms standard platinum based chemotherapy in the first line treatment of HER2 expressing locally advanced or metastatic urothelial carcinoma. The results are striking: Progression free survival was nearly doubled (13.1 months versus 6.5 months; HR = 0.36); Overall survival showed a remarkable improvement (31.5 months versus 16.9 months; HR = 0.54); Benefits were consistent across all HER2 expression levels (IHC 1+, 2+, and 3+); and The combination also exhibited a more favorable safety profile. These findings represent a paradigm shift. For the first time, a biomarker directed strategy has proven superior to chemotherapy in the first line setting for advanced UC. Given that HER2 expression is found in up to 70% of urothelial carcinomas, this new regimen could benefit a majority of patients. In this context, the work by Huang et al gains even greater importance. Their observation that nearly half of UTUC tumors (46.2%) show HER2 positivity especially in high grade disease suggests that a substantial proportion of UTUC patients may be candidates for this novel, highly effective combination therapy. The authors call for clinical trials evaluating HER2 targeted therapies in high grade, HER2 positive UTUC is now more urgent than ever. Future studies should urgently validate the efficacy of disitamab vedotin plus toripalimab in UTUC specific cohorts and explore its potential in earlier disease stages. The era of biomarker driven therapy for urothelial carcinoma has arrived, and HER2 is firmly at its center. Reference: Sheng X, He Z, Zhang G, et al. Primary results from the phase 3 RC48 C016 trial: Disitamab vedotin plus toripalimab versus chemotherapy as first line treatment for HER2 expressing locally advanced or metastatic urothelial carcinoma. Annals of Oncology 2025;36(Supplement 3):S1573 S1574. "
[Collapse]
Huang L, He J. Human epidermal growth factor receptor 2 overexpression is associated with high-grade tumors in upper tract urothelial carcinoma. World J Clin Oncol 2025; 16(10): 110047
13
"This review on the gut-liver axis provides a highly insightful and comprehensive exploration of the evolving role of the microbiome ..."
[Read more]
"This review on the gut-liver axis provides a highly insightful and comprehensive exploration of the evolving role of the microbiome in liver diseases. It successfully ties together mechanisms of microbiome dysbiosis with the pathogenesis of various hepatic conditions, including metabolic dysfunction-associated liver disease, cirrhosis, and cholangiopathies. The authors delve into how imbalances in gut microbiota disrupt bile acid metabolism, increase intestinal permeability, and promote inflammation, which in turn drives liver injury. The article's coverage of emerging treatment options, including bacteriophage therapy and genetic engineering of gut microbes, is particularly noteworthy, reflecting a growing understanding of the microbiome's potential as a therapeutic target. This forward-thinking approach adds substantial clinical relevance, making the article valuable for researchers and clinicians looking to integrate microbiome-based therapies into practice. "
[Collapse]
Anis MA, Shahid Y, Majeed AA, Abid S. Microbiome and gut-liver interactions: From mechanisms to therapies. World J Gastroenterol 2025; 31(40): 111409
14
"This study offers a compelling and innovative exploration of colonoscopy quality, addressing the critical interplay between insertion ..."
[Read more]
"This study offers a compelling and innovative exploration of colonoscopy quality, addressing the critical interplay between insertion time and withdrawal duration to optimize adenoma detection rate (ADR). The proposed "insertion-to-withdrawal" paradigm marks a significant departure from fixed withdrawal time standards, advocating for a personalized approach—a novel and practical advancement. The development of a Shiny app to deliver real-time, individualized guidance further enhances its clinical relevance, providing endoscopists with a valuable tool to improve outcomes. Several aspects warrant deeper consideration. First, the hybrid SVM-XGBoost model's modest discriminative performance (AUC ≈ 0.64) suggests limitations in its current predictive power, likely due to unaddressed variables such as bowel preparation nuances, insertion difficulty, or segment-specific inspection times. Expanding the dataset with multicenter inputs and incorporating these factors could refine its accuracy. Second, while insertion time serves as a proxy for procedural complexity, its validation against objective difficulty scales or video analysis would bolster the mechanistic basis of the findings. Third, the personalized strategy’s generalizability remains untested; prospective multicenter validation across diverse demographics, endoscopist expertise, and regions is essential. Finally, evaluating real-world app adoption and its impact on ADR adherence would provide critical evidence of its efficacy. Overall, this study lays a robust foundation for data-driven personalization in endoscopy, moving beyond uniform metrics. With further refinement and validation, it has the potential to transform clinical practice significantly. "
[Collapse]
Xu BX, Xu CZ, Zhang HY, Chen XJ, Wei BN, Yang C. Personalizing withdrawal time by insertion time to achieve target adenoma detection rate in colonoscopy. World J Gastroenterol 2025; 31(38): 111364
15
"I want to congratulate Yang-Yang Xiong for publishing an excellent study comparing Endoscopic Clip or EUS Coil-assisted glue for ..."
[Read more]
"I want to congratulate Yang-Yang Xiong for publishing an excellent study comparing Endoscopic Clip or EUS Coil-assisted glue for gastric varices. The authors have shown that EUS-guided therapy is more costly and involves high operating time; however, it has similar technical eradication of gastric varices and re-bleeding rates even in larger varices > 4 cm. The size comparison may not be uniform, as the Endoscopic group measured by endoscopic appearance, which may be as accurate as EUS measurement. The Authors have shown only a 5-day rebleeding rate; adding delayed rates could have been more impactful. There is a discrepancy in the table and image regarding post-injection ulcer; the Image shows a post-glue ulcer in both groups, whereas in the table, it was zero; these typographical errors could have been avoided. The eradication time frame is not mentioned; whether it is immediately or 5 days, as the rebleeding rate or any other time frame is not clear. The Follow up endoscopy data is not given; if done even after CT showing eradication of varices or for other GI Bleeding, the time at which it was done was not mentioned, and the procedure done when eradication is not established is also not given. Despite these limitations the study has provided a meaning ful comparison and can change my practice "
[Collapse]
Xiong YY, Li DW, Zhou TY, Ma H, Gao JG, Shen Z, Xu CF, Yu CH. Clip-assisted endoscopic cyanoacrylate injection vs endoscopic ultrasound-guided coil and cyanoacrylate injection for gastric varices: A propensity score-matched study. World J Gastroenterol 2025; 31(38): 111363
16
"This article provides a timely and valuable overview of emerging therapeutic strategies for managing IBD. The integration of physical ..."
[Read more]
"This article provides a timely and valuable overview of emerging therapeutic strategies for managing IBD. The integration of physical exercise and VNS as adjuncts to traditional pharmacological treatments is particularly relevant, as clinicians are increasingly seeking non-invasive and complementary approaches to help manage chronic inflammatory diseases. The article does an excellent job of explaining how these interventions may improve autonomic regulation, reduce inflammation, and promote gut health, which are all essential factors in managing the symptoms and progression of IBD. The focus on the vagus nerve’s role in regulating the immune system through the cholinergic anti-inflammatory pathway presents an interesting potential for VNS as a therapeutic tool. The idea that VNS could restore normal immune function, protect the intestinal barrier, and improve the composition of the gut microbiota is compelling, especially for patients who do not respond adequately to conventional treatments. This could open new avenues for clinical practice, offering patients a holistic approach to managing IBD. However, one of the challenges noted in the article is the variability in response to these non-pharmacological interventions. The review highlights how factors such as exercise intensity, duration, and individual patient factors can influence outcomes. This reflects a common issue in clinical practice, where personalized approaches are often required to determine the best intervention for a given patient. While the evidence for the benefits of physical exercise and VNS in IBD is promising, further studies are needed to establish standardized protocols and validate these therapies in diverse patient populations. The inclusion of vagotomy as a counterpoint to VNS and exercise also brings an important clinical consideration into focus. The article explains how vagotomy, by disrupting the vagal pathway, may exacerbate intestinal inflammation and worsen IBD symptoms. This serves as a reminder of the delicate balance between parasympathetic and sympathetic nervous system function and the potential risks of interfering with this balance in patients with chronic inflammatory conditions. "
[Collapse]
da Silva ACA, Severo JS, dos Santos BLB, Soares HS, Martins JA, Lima RSP, Gadelha KKL, Torres-Leal FL, Correia-de-Sá P, Magalhães PJC, Santos AA, da Silva MTB. Role of physical exercise, vagal nerve stimulation, and vagotomy in inflammatory bowel disease. World J Gastroenterol 2025; 31(38): 111252
17
"This article offers a thorough and insightful overview of the transformative potential of multimodal AI in gastroenterology and ..."
[Read more]
"This article offers a thorough and insightful overview of the transformative potential of multimodal AI in gastroenterology and hepatology. The application of AI across various clinical areas—from early diagnosis to precision treatment—holds great promise. However, the limitations in current AI models—such as lack of data standardization, poor model interpretability, and the need for large-scale, multi-center trials to validate findings—are all issues that would resonate with healthcare professionals. It is crucial for the clinical community to address these issues to ensure that AI technologies can be seamlessly integrated into practice without compromising patient safety or clinical outcomes. "
[Collapse]
Wu YM, Tang FY, Qi ZX. Multimodal artificial intelligence technology in the precision diagnosis and treatment of gastroenterology and hepatology: Innovative applications and challenges. World J Gastroenterol 2025; 31(38): 109802
18
"Gestational diabetes (GD) is a complex disorder with metabolic, inflammatory, genetic, and fetoplacental unit display. The screening ..."
[Read more]
"Gestational diabetes (GD) is a complex disorder with metabolic, inflammatory, genetic, and fetoplacental unit display. The screening is based on oral glucose tolerance tests (OGTT) (one-step and two-step), OGTT is limited by low sensetivity. I addition, it is combersome test and the recommendations and cut-off varied significantly between International Organization. GD is common and is associated with poor maternal and fetal outcomes and the development of type 2 diabetes. The intergration of metabolic, inflammatory, genetic, urinary, and placental biomarkers is highly relevant for the personalized approach among various women. The article is of great interset worldwide, I am very thrilled to write and editorial on this interesting manuscript. Hyder Mirghani, Professor of Internal Medicine and Endocrine, University of Tabuk, Saudi Arabia "
[Collapse]
Kaymak D, Ozgu-Erdinc AS. Advances in gestational diabetes mellitus screening: Emerging trends and future directions. World J Diabetes 2025; 16(10): 111309
19
"Hu et al. (World J Gastroenterol. 2025;31:109528) presented a multicenter study evaluating image-guided thermal ablation (IGTA) for ..."
[Read more]
"Hu et al. (World J Gastroenterol. 2025;31:109528) presented a multicenter study evaluating image-guided thermal ablation (IGTA) for oligometastatic colorectal cancer (CRC) with lung involvement. Among 336 patients treated between 2014 and 2022, the 3- and 5-year overall survival rates were 59.5% and 41.0%, respectively, demonstrating meaningful long-term benefit. Extrapulmonary metastases, particularly in the bone and abdominal cavity, significantly worsened outcomes, whereas patients with liver-only metastases had comparatively favorable survival. Elevated tumor markers (CEA, CA19-9), greater tumor burden, and absence of systemic therapy were adverse prognostic factors. Notably, combining IGTA with systemic therapy improved overall survival. This study underscores IGTA as a viable, minimally invasive treatment for patients with oligometastatic CRC and highlights the prognostic relevance of metastatic distribution in guiding personalized therapy. "
[Collapse]
Hu XF, Dong XJ, Gu XY, Hu JH, Li XH, Zhao FH, Xia XW, Fan HJ, Xu SF. Extrapulmonary metastases impact survival outcomes of thermal ablation for colorectal lung oligometastases: A multicenter study. World J Gastroenterol 2025; 31(38): 109528
20
"Hyperuricemia and high density lipoproteins are imprortant metabolic and inflammatory biomarkers, they are easy to obtain. In ..."
[Read more]
"Hyperuricemia and high density lipoproteins are imprortant metabolic and inflammatory biomarkers, they are easy to obtain. In addition, they are among the cardiovascular risk factors (among other ) and are component of the metabolic syndrome. Depression and tpe 2 diabetes are common health disorders with significant burden on the patients, healthcare system, and the community. When the above diseases present together they exacerbate each other serious consequences. Assessing the uric acid-to-high-density lipoprotein cholesterol ratio in diabetes and psychological disease is highly relevant because they are attainable and the literature on these important parameters is scarce. Thank you very much for the invitation and I would like to publish a letter to the Editor on this interesting topic. "
[Collapse]
Xu H, He DJ, Luo C, Yu XM, Duan CZ, Sun D, Wu DJ, Mao XQ, Jiang WF. Association between uric acid to high-density lipoprotein ratio and mental health symptoms in people with type 2 diabetes. World J Diabetes 2025; 16(10): 110211
1100 items Read more >>
- ALL AUTHOR RESOURCES
- Allegations of Misconduct
- Appeals and Complaints
- Article Processing Charge
- Common Usage of Quantities and Units
- Copyright License Agreement
- Create an Account
- Criteria for Authorship
- Ethics Committee of BPG
- Ethics Statements
- Guidelines for Authors
- Journals
- Language Editing Process for Manuscripts Submitted by Non-Native Speakers of English
- Methods of Post-Publication Debate
- Open-Access
- Publication Misconduct
- Quality of Publications
- Steps for Submitting Manuscripts
- Submit a Manuscript
- ALL PEER-REVIEWER RESOURCES
- Manuscript Decision
- Peer-Review Process
- Peer-Reviewer Tracking for Manuscripts
- Reviewer Acknowledgment
- REFERENCE CITATION ANALYSIS
- Find a Category
- Find a Journal
- Find a Scholar
- Find an Academic Assistant
- Find an Article
- Find an Article PDF
- Subscribe
- Today's Articles
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
California Corporate Number: 3537345
California Corporate Number: 3537345