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1207 items Read more >>
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"We are very satisfied with the overall process of submission and publication. The online submission system was highly convenient, ..."
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"We are very satisfied with the overall process of submission and publication. The online submission system was highly convenient, and the submission workflow was clear and well organized. The valuable comments from the reviewers, editors, and Editor-in-Chief greatly improved the quality of our manuscript. We sincerely thank the Editor-in-Chief, the handling editors, the reviewers, and the production staff for their dedication and hard work. It has been a very pleasant experience for us to publish in World Journal of Gastrointestinal Oncology, and we would highly recommend this journal to our colleagues in the field for its scientific integrity and efficient publication process. "
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Chen TL, Yu XQ. Value of gastric cancer clinical decision support system in a single-center clinical application. World J Gastrointest Oncol 2026; 18(4): 115146
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"We are delighted to have our work accepted by this journal. The review process was highly efficient and professional; the reviewers’ ..."
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"We are delighted to have our work accepted by this journal. The review process was highly efficient and professional; the reviewers’ constructive and insightful comments greatly helped improve the quality of our manuscript. We sincerely appreciate the editorial team’s prompt handling and rigorous yet friendly attitude throughout the submission process. "
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Long JF, Deng LM, Zhang JD, Tang ZJ, Zhou K. Risk characteristics of obesity and atherosclerotic cardiovascular events in patients with schizophrenia: A single-center 10-year retrospective cohort study. World J Psychiatry 2026; 16(4): 114138
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"The authors have no specific additional comments at this stage. We thank the editorial team and reviewers for their valuable time ..."
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"The authors have no specific additional comments at this stage. We thank the editorial team and reviewers for their valuable time and insightful suggestions, which have greatly enhanced the quality of our work. The overall processing was efficient and fair. We are satisfied with the review outcome and the journal’s professional management. "
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Lin J, Chen ZF, Guo GD, Chen X. Correction to “Impact of Alcian blue and periodic acid Schiff expression on the prognosis of gastric signet ring cell carcinoma”. World J Gastrointest Oncol 2026; 18(4): 118402
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"The entire submission, review and publication process of this journal is highly standardized and efficient, leaving me a very positive ..."
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"The entire submission, review and publication process of this journal is highly standardized and efficient, leaving me a very positive experience. From the user-friendly online submission system to the timely and professional peer review feedback, every link is well-organized. The reviewers provided objective, rigorous and highly constructive comments that greatly helped improve the academic quality of my manuscript. The editorial team was patient, responsible and efficient in communication, and the editing, typesetting and publication work were meticulous and in place. The whole process was smooth and satisfactory. I sincerely appreciate all the staff for their professional service and hard work, and I am willing to submit manuscripts to this journal again in the future and recommend it to colleagues and peers. "
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Yu AX, Liang WH, Zhou YS, Li P, Ji JM, Zhang FW, Yu P, Liu J. Xianling Gubao capsule alleviates osteoporosis: Modulation of gut-bone axis and Wnt signaling. World J Orthop 2026; 17(4): 116046
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"I sincerely appreciate your prompt and thorough evaluation of our manuscript, as well as your consideration in publishing our work. ..."
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"I sincerely appreciate your prompt and thorough evaluation of our manuscript, as well as your consideration in publishing our work. The review process was both efficient and constructive, providing valuable feedback that helped improve the quality of our study. I am very impressed by the professionalism and timeliness of the editorial process, and I would be pleased to consider submitting future research to this journal. "
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Kim M, Chi SA, Kim JE, Kim ER, Hong SN, Kim YH, Kim K, Chang DK. Optimal strategies for mitigating gastrointestinal bleeding in patients receiving antiplatelet therapy: Real-world study. World J Gastroenterol 2026; 32(14): 115790
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"I am very grateful for your prompt evaluation of our paper and for publishing it. I have submitted my papers to this journal in the ..."
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"I am very grateful for your prompt evaluation of our paper and for publishing it. I have submitted my papers to this journal in the past and they have been accepted. I would like to continue submitting papers to your journal and disseminating the results of our research. I look forward to your continued support. Toshiyuki Kakinuma "
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Kakinuma K, Kakinuma T, Ueyama K, Okamoto R, Yanagida K, Takeshima N, Ohwada M. Uterine artery pseudoaneurysm caused by hysteroscopic surgery: A case report. World J Clin Cases 2024; 12(26): 5968-5973
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"I am very grateful for your prompt evaluation of our paper and for publishing it. I have submitted my papers to this journal in the ..."
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"I am very grateful for your prompt evaluation of our paper and for publishing it. I have submitted my papers to this journal in the past and they have been accepted. I would like to continue submitting papers to your journal and disseminating the results of our research. I look forward to your continued support. Toshiyuki Kakinuma "
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Ueyama K, Kakinuma T, Mori K, Hayashi A, Kakinuma K, Okamoto R, Kaneko A, Yanagida K, Takeshima N, Ohwada M. Managing Vogt–Koyanagi–Harada disease during pregnancy with steroid pulse therapy: A case report. World J Clin Cases 2024; 12(31): 6493-6499
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"I am very grateful for your prompt evaluation of our paper and for publishing it. I have submitted my papers to this journal in the ..."
[Read more]
"I am very grateful for your prompt evaluation of our paper and for publishing it. I have submitted my papers to this journal in the past and they have been accepted. I would like to continue submitting papers to your journal and disseminating the results of our research. I look forward to your continued support. Toshiyuki Kakinuma "
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Segawa A, Kakinuma T, Miyazawa C, Takeuchi J, Tamura M, Morita A, Takae S, Suzuki N, Ariizumi Y. Successful perioperative management for a giant ovarian tumor in older adults: A case report. World J Clin Cases 2026; 14(4): 116737
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"The experience of submitting to this journal was excellent. The submission system is user-friendly, and the process is relatively ..."
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"The experience of submitting to this journal was excellent. The submission system is user-friendly, and the process is relatively straightforward. Most importantly, the reviewers provided very constructive suggestions and comments. Additionally, the editors of the journal are highly diligent and responsible, communicating with authors promptly. Overall, I am very satisfied with the experience of submitting to this journal. "
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Liu CR, Zhang M, Wang MQ, Zhang W, Li J, Shi GZ, Liang FF, Li YP, Huang N. CD161+CD8+ T cells in patients with hepatitis B virus-associated hepatocellular carcinoma. World J Gastrointest Oncol 2026; 18(4): 114547
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"I am very satisfied with the overall experience of publishing in this journal. The submission system is well-designed, intuitive, ..."
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"I am very satisfied with the overall experience of publishing in this journal. The submission system is well-designed, intuitive, and efficient, which makes the processes of manuscript submission, revision, and resubmission straightforward and convenient. The peer-review process was rigorous and highly professional. The reviewers provided insightful, constructive, and detailed comments that greatly helped improve the scientific quality, clarity, and structure of our manuscript. Their feedback was invaluable in refining our work. In addition, the editorial team demonstrated excellent professionalism, with prompt responses and clear communication at every stage. Overall, the entire publication process was smooth and efficient, reflecting the journal’s strong commitment to high academic standards. "
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Lei XD, Qian GX, Sun ZG, Tang ZQ, Liu YC, Du R, Li YH. Deep learning radiomics nomogram based on multi-regional features for predicting lymph node metastasis and prognosis in colorectal cancer. World J Gastrointest Oncol 2026; 18(4): 115635
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"My experience publishing with World Journal of Clinical Pediatrics was seamless from submission to final publication. The editorial ..."
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"My experience publishing with World Journal of Clinical Pediatrics was seamless from submission to final publication. The editorial office provided excellent support, maintaining clear and prompt communication throughout every stage. Furthermore, the peer-review process was both rigorous and fair, offering valuable insights that strengthened the impact of my work. I am grateful for the professionalism shown by the team and would certainly choose to publish here again in the future. "
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Marie A, François-Garret B, Filippi A, Eleni Dit Trolli S, Casagrande F, Lotte JB, Guellec I, Fernandez A. Factors influencing parental presence in neonatal units: A systematic review. World J Clin Pediatr 2025; 14(4): 107552
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"Outstanding integrity in its publication. To disseminate reliable research results and to serve as a currency for measuring the ..."
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"Outstanding integrity in its publication. To disseminate reliable research results and to serve as a currency for measuring the achievements of scientists. Competent peer review is already stretched thin, largely because it relies on unpaid labour that is considered part of scientists’ professional duties. As a free resource, it is therefore subject to overuse. "
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Biswas MS, Mawa MJ. Different treatments, different minds: The overlooked side of ovarian cancer care. World J Psychiatry 2026; 16(4): 114973
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"The journal's interface was smooth and effective. The rigorous review process was amazing, and the coordination via email was up to ..."
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"The journal's interface was smooth and effective. The rigorous review process was amazing, and the coordination via email was up to the mark. We plan to submit more papers, if applicable, to the journal. The submission, revision, re-evaluation, language check, quality check, and production went smooth and without any issue other than the quality step-wise approach. "
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Tariq Z, Faisal A, Basit A, Iftikhar A, Basil AM. Diagnostic dilemmas in hepatoid adenocarcinoma of the stomach: Navigating clinical and pathological loopholes. World J Methodol 2026; 16(1): 110272
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"The submission system is highly convenient, efficient, and easy to use, which greatly simplifies the processes of manuscript handling, ..."
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"The submission system is highly convenient, efficient, and easy to use, which greatly simplifies the processes of manuscript handling, revision, and resubmission. It allows authors to complete each step in a clear and organized manner, thereby improving overall communication and workflow efficiency. In addition, the reviewer’s report is অত্যন্ত helpful, professional, and constructive for the improvement of our manuscript. The comments and suggestions provided are insightful and detailed, enabling us to identify weaknesses, clarify important points, and further enhance the scientific quality, logical structure, and presentation of the manuscript. We sincerely appreciate the valuable feedback, which has played an important role in strengthening our work. "
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Liu YM, Liu M, Yuan H, Li B. Double-edged role of N6-methyladenosine reader YTH structural domain family protein 2 in neurological disorders: Molecular mechanisms and translational prospects. World J Exp Med 2026; 16(1): 116383
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"The peer review time was relative long. However, I understand this situation because it encounterd several times of unreceived review ..."
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"The peer review time was relative long. However, I understand this situation because it encounterd several times of unreceived review request. And finally the reviwer's opinion was fairly object and constructive, which was very helpful for us to improve the manuscript. Thanks very much for the editor and reviewer's help. "
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Li XA, Chen JY, Bu J, Wu HW. Customized three-dimensional printed titanium ribs combined with bilateral flaps for reconstruction of chest wall defect: A case report. World J Orthop 2026; 17(4): 117533
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"I am appreciatied for the exceptional editorial services provided by F6 Publishing and the Baishideng Publishing Group. The entire ..."
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"I am appreciatied for the exceptional editorial services provided by F6 Publishing and the Baishideng Publishing Group. The entire publication process was handled with remarkable professionalism and efficiency. The online submission system is highly intuitive and user-friendly, making the management of manuscripts and supplementary materials very straightforward. Furthermore, the peer-review process was both rigorous and constructive; the reviewers' insightful comments significantly enhanced the academic quality and clarity of our research. I would also like to thank the editorial staff for their prompt and clear communication throughout each stage. It has been a pleasure publishing with such a prestigious group. "
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Lin ZH, He Y, Xu HX, Xiao L. Cost-effectiveness analysis of seven treatments vs sorafenib as first-line therapy for advanced hepatocellular carcinoma in China. World J Gastrointest Oncol 2026; 18(4): 113266
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"Upon the publication of our article "Serum 5-hydroxytryptamine levels as biomarkers for motor dysfunction and depression in Parkinson’s ..."
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"Upon the publication of our article "Serum 5-hydroxytryptamine levels as biomarkers for motor dysfunction and depression in Parkinson’s disease patients" in World Journal of Psychiatry (WJP), we would like to express our sincere gratitude to the editorial team and reviewers for their rigorous and constructive feedback. Their insightful suggestions significantly improved the quality of our work, particularly regarding the description and validation of the depression assessment questionnaire used in this study. We are also deeply thankful to all the Parkinson’s disease patients who participated in this research, completing the standardized questionnaire with patience and cooperation. The publication of this study in WJP, a journal dedicated to advancing psychiatric research, is a great honor for our team. We hope our findings—linking serum 5-hydroxytryptamine levels to both motor dysfunction and depression—will provide new insights into the clinical assessment and potential biomarker development for Parkinson’s disease. Finally, we thank our affiliated institutions for continuous support throughout the research process. "
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Chen YS, Yang SY, Lu KY, Li M, Liu T, Zhu SG, Lu HL, Hu K. Serum 5-hydroxytryptamine levels as biomarkers for motor dysfunction and depression in Parkinson’s disease patients. World J Psychiatry 2026; 16(4): 114462
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"Extremely satisfied with the peer review system. Made me realize the small improvements which I can make to my manuscript. This went ..."
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"Extremely satisfied with the peer review system. Made me realize the small improvements which I can make to my manuscript. This went a long way in finalizing a good manuscript. This is how peer-review should be done in constructive manner. This also ensured that our scientific quality improved after submisson of manuscript. "
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Karan N, Patnaik R, Priyanka DS, Sharma AK. Transient drooping lid after scalp block during deep brain stimulation for Parkinson’s disease: A case report. World J Clin Cases 2026; 14(11): 119896
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"There is a great deal of work from the editing team, in terms of language, formatting, showcasing online the performed job, and the ..."
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"There is a great deal of work from the editing team, in terms of language, formatting, showcasing online the performed job, and the overall transparency of the entire process. Such a work has really facilitated the publication from the initial draft to the last version, the one that is available actually in print. "
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Djamandi P, Gorica H, Kyriakou O, Xhukellari E, Rroji A, Vyshka G. Late-onset neurological manifestations of X-linked adrenoleukodystrophy in a male with childhood-onset Addison’s disease: A case report. World J Clin Cases 2026; 14(11): 119232
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"I am very satisfied with all the services provided by the journal, with timely responses from the editors and professional and ..."
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"I am very satisfied with all the services provided by the journal, with timely responses from the editors and professional and scientific feedback from the reviewers. They have provided valuable suggestions to enrich the content of the article and hope to accelerate the review process. I wish the journal continued success and prosperity "
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Wang DY, Yuan MY, Zhi H. Comorbid depression and glycemic instability in adolescent type 1 diabetes: Clinical insights into suicide risk. World J Psychiatry 2026; 16(4): 117207
21135 items Read more >>
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"The authors deserve praise for coming up with a new and well-thought-out way to solve a difficult clinical problem. This case report ..."
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"The authors deserve praise for coming up with a new and well-thought-out way to solve a difficult clinical problem. This case report beautifully shows how customised three-dimensional printed titanium ribs can be used successfully with bilateral flap coverage to fix a complicated chest wall defect. Combining cutting-edge 3D printing technology with sound reconstructive surgical principles is a forward-thinking approach that works well and looks good.
The manuscript is well-organised, clearly written, and backed up by relevant clinical information and images. It gives thoracic and reconstructive surgeons a lot of useful information about planning before surgery, customising implants, and surgical techniques. This report adds important information to the growing field of personalised surgical reconstruction and sets a good example for how it can be used in the future."
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Li XA, Chen JY, Bu J, Wu HW. Customized three-dimensional printed titanium ribs combined with bilateral flaps for reconstruction of chest wall defect: A case report. World J Orthop 2026; 17(4): 117533
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"The manuscript "Management and Prevention of Iatrogenic Ipsilateral Femoral Neck Fracture During Intramedullary Nailing of Femoral ..."
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"The manuscript "Management and Prevention of Iatrogenic Ipsilateral Femoral Neck Fracture During Intramedullary Nailing of Femoral Shaft" talks about a clinically important but often overlooked problem in orthopaedic trauma surgery. The authors did a great job of stressing how important it is to be careful during intramedullary nailing. They also talked about both ways to avoid problems and how to handle them when they do happen.
The article is well-organised, with a clear progression from identifying the problem to finding solutions that work. The focus on early diagnosis, safety measures during surgery, and imaging protocols adds a lot of clinical value. The section on technical details and surgical tips is especially interesting, making the paper very useful for both new and experienced surgeons.
The manuscript adds to the existing body of literature by putting together current evidence and making recommendations that can help lower complication rates and improve patient outcomes. In general, this article is well-written, informative, and useful in a clinical setting, so it should be published."
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Nallakumarasamy A, Vetrivel VN, Balaji VP, Yadav R, Jeyaraman N, Muthu S, Jeyaraman M. Management and prevention of iatrogenic ipsilateral femoral neck fracture during intramedullary nailing of femoral shaft. World J Orthop 2026; 17(4): 116107
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" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..."
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" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Usuda D, Furukawa D, Imaizumi R, Ono R, Kaneoka Y, Nakajima E, Kato M, Sugawara Y, Shimizu R, Inami T, Sakurai R, Kawai K, Matsubara S, Tanaka R, Suzuki M, Shimozawa S, Hotchi Y, Osugi I, Katou R, Ito S, Mishima K, Kondo A, Mizuno K, Takami H, Komatsu T, Nomura T, Sugita M. Perforative peritonitis caused by long-term retention of a rectal foreign body: A case report. World J Clin Cases 2026; 14(11): 119572
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"Congratulations on the publication of your paper. This is a significant achievement, and I am delighted to see that your dedicated ..."
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"Congratulations on the publication of your paper. This is a significant achievement, and I am delighted to see that your dedicated efforts in daily clinical practice and academic work have borne fruit.
I read your paper with great interest, particularly because my own specialty is emergency medicine. I also occasionally encounter cases of anorectal foreign bodies in clinical practice, and I believe your paper will serve as a highly valuable reference for the management of such cases in the future.
The manuscript is very well organized, clear, and easy to follow. In addition, it incorporates up-to-date information and presents the topic in a balanced and informative manner. Overall, I consider this to be a high-quality paper of substantial clinical value.
In recognition of these strengths, I would give this work the highest evaluation. Writing and publishing a paper while maintaining a busy clinical workload is no small accomplishment, and I sincerely hope that you will continue to build on this success and further expand your academic achievements.
Congratulations once again on this excellent work."
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Usuda D, Furukawa D, Imaizumi R, Ono R, Kaneoka Y, Nakajima E, Kato M, Sugawara Y, Shimizu R, Inami T, Sakurai R, Kawai K, Matsubara S, Tanaka R, Suzuki M, Shimozawa S, Hotchi Y, Osugi I, Katou R, Ito S, Mishima K, Kondo A, Mizuno K, Takami H, Komatsu T, Nomura T, Sugita M. Perforative peritonitis caused by long-term retention of a rectal foreign body: A case report. World J Clin Cases 2026; 14(11): 119572
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"5-FU is the basis of the therapeutic regimens for the pharmacological treatment of gastric cancer (GC). However, the main downside ..."
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"5-FU is the basis of the therapeutic regimens for the pharmacological treatment of gastric cancer (GC). However, the main downside of this treatment is the development of resistance, which, understandably, negatively affects patients’ clinical outcomes. Therefore, innovative therapeutic strategies are needed to overcome 5-FU resistance and improve the prognosis of GC. The authors of the study under review investigated the effects of Xiangshaliujunzi decoction (XSLJZD) on GC cell lines. They found that XSLJZD inhibited cell viability and proliferation, while promoting PANoptosis in 5-FU-resistant cells. Suppression of ZEB1 increased pyroptosis, apoptosis, and the expression of other proteins associated with programmed cell death.
The selection of this work for comment was based on two reasons: i) the use of complementary therapy, whether or not based on traditional Chinese Medicine in the treatment of various benign and malignant digestive disorders, should be adopted internationally. The results are no longer empirical but are based on valid clinical and laboratory data, ii) The authors, in designing their study, among other things, investigated the effect of PANoptosis processes (apoptosis, pyroptosis, and necroptosis) which are a very hot topic of research internationally not only in malignant digestive diseases, but also in a host of other benign conditions such as inflammatory bowel disease. Their results, although experimental, reinforce the view that XSLJZD overcomes 5-fluorouracil (5-FU) resistance in GC by inducing PANoptosis."
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Gao H, Yin DF, Xing XR, Zhou LJ, Yu R. MiR-200a-3p/ZEB1/IRF1-mediated PANoptosis prompts Xiangshaliujunzi decoction to overcome 5-fluorouracil resistance in gastric cancer. World J Gastroenterol 2026; 32(14): 114331
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"This draft provides a clear and engaging overview of diabetic retinopathy (DR), presenting it as more than just a vascular complication ..."
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"This draft provides a clear and engaging overview of diabetic retinopathy (DR), presenting it as more than just a vascular complication and highlighting its neurovascular nature. Diabetic retinopathy (DR), and its effective explanation as a complex, multifactorial, and increasingly recognized neurovascular disorder rather than solely a microvascular complication. The paper effectively emphasizes the global burden of the disease and the limitations of current treatments, especially anti-VEGF therapies, while drawing attention to the importance of early retinal changes. One of the main strengths of the review is its broader perspective beyond glucose control. The discussion of inflammation, lipid metabolism, and immune processes is well integrated and reflects current thinking in the field. The discussion of broader perspective as “beyond-glycemia” framework, reinforcing the need for multidimensional therapeutic strategies. The writing flows logically, making complex mechanisms easier to follow. The section on the gut-retina axis is particularly interesting and adds a fresh dimension to the topic. It clearly explains how gut microbiota may influence retinal health through metabolic and immune pathways. The inclusion of microbial metabolites, extracellular vesicles, and immune modulation as mediators of gut-retina communication demonstrates a developed understanding of the current evidence. Overall, the draft is well-organized, informative, and forward-looking, with a strong focus on potential new therapies and future research directions.
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Zeppieri M, Drigo A, Capobianco M, Visalli F, Cappellani F, Musa M, Giglio R, Tognetto D, Khouyyi M, Gagliano C, D’Esposito F, Inferrera L. Beyond glycemia: The influence of systemic inflammation, lipids, and the gut-retina axis in diabetic retinopathy. World J Diabetes 2026; 17(3): 114603
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"It has been stated that PPI s alone are good effective for aspirin induced gastrointestinal bleeding, but not sufficiently effective ..."
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"It has been stated that PPI s alone are good effective for aspirin induced gastrointestinal bleeding, but not sufficiently effective for clopidogrel induced gastrointestinal bleeding. However,co-administration with rebamipide provides sufficient hemostatic effect. Please comment the reason why pPI with rebamipide is good effect for the gastrointestinal bleeding with clopidogrel.
Please comment the side effect of long term with pPI use."
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Kim M, Chi SA, Kim JE, Kim ER, Hong SN, Kim YH, Kim K, Chang DK. Optimal strategies for mitigating gastrointestinal bleeding in patients receiving antiplatelet therapy: Real-world study. World J Gastroenterol 2026; 32(14): 115790
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"The article explains very well the relevance of the Boruta variables in the clinical-endoscopic model for AIG-associated G-NETs and ..."
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"The article explains very well the relevance of the Boruta variables in the clinical-endoscopic model for AIG-associated G-NETs and clearly highlights its strengths and limitations. The text structure is good, and the logical presentation of information facilitates the understanding of the process and the mechanisms involved.
In addition, the text is grammatically correct, managing to present new perspectives on how feature selection and the integration of clinical and endoscopic biomarkers can contribute to risk stratification and personalized management of patients with AIG. This approach makes a clear contribution to the specialized literature, opening avenues for future research and practical application of predictive models.
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Yu QQ. Risk stratification of gastric neuroendocrine tumors in autoimmune gastritis: Evaluating the clinical value of an integrated clinical-endoscopic model. World J Gastroenterol 2026; 32(13): 115440
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"This is a well-written and presented a rare case report on Splenic tuberculous mass following anti-tuberculosis therapy was ..."
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"This is a well-written and presented a rare case report on Splenic tuberculous mass following anti-tuberculosis therapy was misdiagnosed as a splenic tumor.
Careful questioning of a patient's medical history is crucial for avoiding misdiagnosis and inappropriate treatment.
In this case, the failure to carefully question the patient's medical history at the outset is a deficiency.
I think that this manuscript is suitable and worth to be published in World Journal of Gastrointestinal Surgery.
"
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Li ZK, Zhang K, Zhang HL, Lv XL, Guo JQ, Tan W. Splenic tuberculous mass following anti-tuberculosis therapy was misdiagnosed as a splenic tumor: A case report. World J Gastrointest Surg 2026; 18(3): 115137
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The article meets basic ethical standards with reported approval, though fuller disclosure of consent procedures would enhance ..."
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The article meets basic ethical standards with reported approval, though fuller disclosure of consent procedures would enhance transparency. The methodology is appropriate and largely reproducible, but lacks some detail on controls and implementation, limiting full replication. Results are logically presented and consistent with the study design, providing partial support for the hypothesis, though broader generalizability is constrained. Figures and tables are relevant but occasionally insufficiently annotated, reducing clarity. Biostatistical analysis is acceptable, yet could be strengthened through more comprehensive reporting of effect sizes and confidence intervals. References are generally current and relevant, although inclusion of additional recent key studies would improve scholarly depth. The language is clear and mostly concise, with minor grammatical issues. Key limitations include a relatively small and possibly non-representative sample, potential bias, and inadequate discussion of confounding factors, all of which may affect the strength and applicability of the conclusions.
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Chen X, Zhang LL, Zhou Y, Dong DX, Qian XY. Mitochondrial autophagy in diabetes-related cognitive decline and skin ulcers: Mechanistic insights and therapeutic implications. World J Diabetes 2026; 17(3): 112177
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"This is a single-center, double-blind, randomized, placebo-controlled trial that enrolled a sufficient number of patients who met ..."
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"This is a single-center, double-blind, randomized, placebo-controlled trial that enrolled a sufficient number of patients who met the Rome IV diagnostic criteria for FD. Patients were randomized to receive LPZ (30 mg once daily) in combination with FM (flupenthixol 0.5 mg + melitracen 10 mg) or a matching placebo for 2 weeks, followed by a 4-week follow-up. At week 2, the clinical response rate was higher in the LPZ + FM group than in the placebo group. The LPZ + FM group showed greater reductions in PDS, SF-NDI, PHQ-9, Generalized Anxiety Disorders-7, and Pittsburgh Sleep Quality Index scores, with improvements maintained throughout the follow-up.
The first comment concerns the usefulness of such studies. These studies are very useful in daily clinical practice precisely because of the magnitude of the problem worldwide.
The second comment concerns the study design. In my opinion, another pure group could be included that would receive only the FM combination. The results could separate the percentage contribution of each regimen to the final clinical outcome.
In any case, as the authors note, multicenter studies are required to demonstrate the effectiveness of a combination of pharmaceutical agents for the treatment of this frequent and condition with significant functional consequences."
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Wang XY, Yin KH, Cheng L, Wang XY, Qiao Y, Tang XR, Wang B, Yan XJ, Chen SL. Efficacy and safety of lansoprazole combined with flupentixol-melitracen for functional dyspepsia: A randomized, double-blinded, placebo-controlled clinical trial. World J Gastroenterol 2026; 32(13): 117115
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"This is a compelling topic with significant clinical relevance.
The development of this system stems from a key gap: while ..."
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"This is a compelling topic with significant clinical relevance.
The development of this system stems from a key gap: while guidelines for several incidental findings already exist, consistent and integrated recommendations within radiology reports are lacking.
The objectives of this proposal were clearly presented and well defined. The aims were to standardize terminology and decision-making for incidental findings while ensuring a transparent and reproducible link between the findings and their corresponding recommendations. Furthermore, the Incidental-Reporting and Data System (I-RADS) seeks to facilitate data collection and establish an infrastructure for artificial intelligence algorithms to learn from clearly labeled, standardized datasets—enabling machine learning, registries, and big-data research in ways that current fragmented guidelines cannot. Additionally, I-RADS can be integrated into structured reporting platforms, thereby streamlining the diagnostic workflow.
I-RADS is not intended to replace existing guidance on incidental findings, such as the ACR recommendations, but rather to complement and consolidate them into a single, simplified cross-sectional system.
The proposed I-RADS system features a conceptual framework designed to provide a unified and simplified approach to the classification and communication of incidental findings across imaging modalities and anatomical regions.
The reviewer acknowledged that the proposal for the Incidental-Reporting and Data System represents an innovative effort with positive implications. However, unlike other systems, I-RADS must account for a wide range of miscellaneous conditions—such as aortic dissection, occult or chronic splenic rupture, thrombus in the left atrium or main pulmonary artery, retained foreign bodies, and displacement of iatrogenic grafts—which, while not malignant, are life-threatening or hazardous. These should be carefully considered. The methodology for the development of I-RADS requires revision, and the efficacy of the system needs to be validated."
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Arkoudis NA, Moschovaki-Zeiger O, Koutserimpas C, Lama N, Velonakis G, Filippiadis D, Spiliopoulos S, Kelekis N. Proposing Incidental-Reporting and Data System: A classification system for incidental findings in radiology. World J Radiol 2026; 18(3): 119025
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"TIPS is good procedure for esophageal varix. This procedure is portal vein -hepatic vein shunt.
TIPS decrease portal pressure and ..."
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"TIPS is good procedure for esophageal varix. This procedure is portal vein -hepatic vein shunt.
TIPS decrease portal pressure and causes highout for heart. Some patient after TIPS suffer from Eck and heart failure. Please comment about the diameter of TIPS and preoperative heart. What kinds of parameter for heart is suitable parameter for heart failure after TIPs?
"
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Zhang TQ, Zhang L, Yong X, Tian C, Chen BJ, Qin JP, Mu D, Tang SH. Transjugular intrahepatic portosystemic shunt for variceal bleeding due to hereditary hemorrhagic telangiectasia with cirrhosis: A case report. World J Gastroenterol 2026; 32(12): 119002
14
" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..."
[Read more]
" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied"
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Siyal M, Tahseen MU, Asim M, Niaz TS, Zakaria N, Leghari A, Niaz SK. Slipped and caught in the cecum: Endoscopic retrieval of a migrated foley feeding jejunostomy tube: A case report. World J Clin Cases 2026; 14(8): 118316
15
"Researchers have concluded that elastography can provide an objective assessment of esophageal varices and may serve as a non-invasive ..."
[Read more]
"Researchers have concluded that elastography can provide an objective assessment of esophageal varices and may serve as a non-invasive screening tool for diagnosis and treatment indication. While abdominal ultrasound follow-up is recommended for patients with chronic liver disease, ultrasound elastography may allow for more appropriate screening of patients requiring esophageal varices via endoscopy. This is expected to reduce the need for upper gastrointestinal endoscopy, which is an uncomfortable procedure for patients, and enable more efficient medical care. Further large-scale prospective studies are needed to further validate the usefulness of this non-invasive assessment "
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Martínez-Díaz FM, Jiménez-Cuevas EA, Morales-Galicia AE, Ramírez-Mejía MM, Qi XS, Poo JL, Méndez-Sánchez N. Toward noninvasive prediction of treatment outcomes in patients with variceal bleeding. World J Gastroenterol 2026; 32(11): 115723
16
"It has long been established that respiratory and digestive diseases coexist in a proportion of patients. This coexistence shares ..."
[Read more]
"It has long been established that respiratory and digestive diseases coexist in a proportion of patients. This coexistence shares significant pathogenetic mechanisms, including microbial, immunological, and metabolic pathways. The combined clinical manifestations of two different systems often require complex therapeutic interventions.
Thus, in recent years, the lung-gut axis has emerged as equally important, underscoring the complex bidirectional regulatory network between gastrointestinal and respiratory diseases. The clinical coexistence of digestive and respiratory system diseases in the same patient poses both diagnostic and therapeutic challenges, and their management should be rational and effective, aiming to reduce the risk of worsening the underlying diseases.
The treatment of these coexisting pathological conditions requires a deep knowledge of their pathophysiology and significant experience in treating them. The need for cooperation between the gastroenterologist and the pulmonologist for the most rational treatment of patients is self-evident. This cooperation for the treatment of combined digestive diseases with diseases of other systems, in my opinion, will be increasingly required in the coming years, as the common pathogenetic mechanisms are clarified and the therapeutic quiver is enriched with new pharmaceutical agents."
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Huang HJ, Liu PP, Dong DF. Research progress on comorbidity between gastrointestinal and pulmonary diseases from the perspective of the gut-lung axis. World J Gastroenterol 2026; 32(11): 115846
17
"Review summary and Recommendations
1. Clinical Context:
Walled-off pancreatic necrosis (WON) is heterogeneous in clinical course. ..."
[Read more]
"Review summary and Recommendations
1. Clinical Context:
Walled-off pancreatic necrosis (WON) is heterogeneous in clinical course. While some patients resolve with transmural drainage alone, others deteriorate and require direct endoscopic necrosectomy (DEN). Chronological criteria, such as the 4-week cutoff in the revised Atlanta classification, do not reliably predict clinical trajectory.
2. Key Findings:
o Persistent sepsis, systemic inflammatory response syndrome (SIRS), hypoalbuminemia, anemia, extensive necrosis (>30–40%), and unfavorable anatomical patterns predict drainage failure and DEN requirement.
o Lone et al’s predictive model (AUC 0.892) demonstrates strong discriminative ability, supporting early identification of patients unlikely to respond to drainage alone.
o The concept of “passive drainage failure” captures patients at high risk, characterized by large solid debris, compartmentalized collections, and persistent systemic inflammation.
3. Step-Up vs Upfront DEN:
o Timing should not be guided solely by predefined intervals but by individualized risk assessment.
o Step-up strategies minimize unnecessary interventions but may delay care in high-risk patients.
o Upfront DEN can prevent deterioration in selected patients but carries higher procedural risk if overused.
o Guidelines support necrosectomy in cases of persistent sepsis, cavity compartmentalization, or failure of cavity collapse despite adequate drainage.
4. Safety Considerations:
o DEN is effective but carries 15–30% complication rates, including bleeding, perforation, stent occlusion, and infection exacerbation.
o Deferring DEN in patients with ongoing infection or high necrotic burden may worsen outcomes and complicate later intervention.
o Risk stratification is essential to balance procedural risk against the risk of inaction.
5. Future Directions:
o Integration of multivariate risk models, incorporating clinical, biochemical, and imaging variables, may individualize timing decisions.
o AI and machine learning could enhance predictive accuracy, using longitudinal data and quantitative necrosis assessment.
o The paradigm shift is toward intervention guided by patient-specific risk rather than temporal thresholds.
Recommendations
1. Clinical Practice:
o Implement early risk stratification in all WON cases to identify patients at high risk of drainage failure.
o Reserve step-up strategies for low-to-moderate risk patients and consider early DEN for high-risk phenotypes.
o Monitor clinical, laboratory, and imaging markers closely to guide escalation decisions.
2. Research:
o Validate predictive models like Lone et al’s across larger, multi-center cohorts.
o Investigate AI-driven, real-time risk scoring systems integrating necrosis quantification and host response metrics.
o Explore the interplay of nutritional status, necrosis morphology, and systemic inflammation as modifiers of intervention timing.
3. Guideline Implications:
o Guidelines should emphasize risk-based rather than time-based criteria for DEN.
o Step-up and upfront strategies should be framed as complementary, with risk stratification as the central decision-making tool.
Bottom Line:
Timing of DEN should transition from protocol-driven intervals to personalized, risk-guided decisions. Intervention becomes appropriate when waiting poses greater risk than acting.
"
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Singeap AM, Chiriac S, Minea H, Trifan A. Between step-up and upfront intervention: Risk stratification as the missing link in timing endoscopic necrosectomy. World J Gastrointest Endosc 2026; 18(3): 116865
18
"This is a high-level evaluation of a study or meta-analysis that summarizes its overall quality, reliability, strengths, limitations, ..."
[Read more]
"This is a high-level evaluation of a study or meta-analysis that summarizes its overall quality, reliability, strengths, limitations, and clinical relevance without going into excessive technical detail. It’s the type of assessment a clinician, journal reviewer, or guideline committee might write to quickly judge how much weight to give the study’s findings.
Overall Quality:
The meta-analysis includes 17 randomized controlled trials with 1,689 patients, representing a moderate-to-high-quality evidence base. The search strategy was comprehensive, covering multiple international and Chinese databases, which minimizes publication bias.
Strengths:
• Large, pooled sample size with randomized controlled trial design.
• Direct comparison between minimally invasive ES and standard TS.
• Evaluates both efficacy and safety, including recovery time and costs.
• Clinically relevant outcomes such as bleeding, prolapse, complications, and hospital stay.
Limitations:
• Variation in ES and TS techniques across studies may introduce heterogeneity.
• Follow-up durations were not consistently reported, limiting assessment of long-term outcomes and recurrence.
• Most studies had relatively small individual sample sizes, which may affect statistical power for less common complications.
Clinical Relevance:
• Provides strong evidence that ES is a safe, effective, and cost-efficient alternative to TS.
• Supports adoption of ES as a first line minimally invasive option for internal hemorrhoid treatment, especially for patients seeking faster recovery.
Conclusion:
The meta-analysis is methodologically sound and clinically meaningful. While some heterogeneity exists, the findings are consistent and indicate that ES offers meaningful advantages over TS in terms of safety, recovery, and cost. Further large-scale, multicenter studies with standardized protocols would strengthen the evidence base.
"
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Wu SY, Chen YS, Li XH, Yu TJ, Xie F, Jiang QF, Lan Y, He P, Li SC, Li WS, Chen WD. Efficacy and safety of endoscopic sclerotherapy vs traditional surgery in the treatment of internal hemorrhoids: A meta-analysis. World J Gastrointest Endosc 2026; 18(3): 116697
19
"Summary: This study presents an exploratory analysis of bilateral upper limb sEMG activity in an experienced endoscopist during ..."
[Read more]
"Summary: This study presents an exploratory analysis of bilateral upper limb sEMG activity in an experienced endoscopist during simulated colonoscopy, focusing on different bowel loop configurations. Key findings include:
• Muscle activation and fatigue: Complex loops significantly increase muscle load and fatigue, particularly in the left extensor digitorum and stabilizing muscles like the left flexor carpi radialis and right middle deltoid.
• Bilateral asymmetry: The left arm consistently sustains high activation, while the right arm shows task-specific activation, suggesting differential biomechanical demands for gross stabilization versus fine manipulation.
• Correlation with procedure duration: Longer insertion times are associated with more rapid fatigue in stabilizer muscles.
• Implications: These results objectively demonstrate increased biomechanical demand during challenging colonoscopy maneuvers, supporting the need for ergonomic interventions, workload management, and device design optimization.
Strengths:
• Comprehensive sEMG analysis across 14 bilateral muscles with high temporal resolution (1500 Hz).
• Clear differentiation of muscle load and fatigue patterns across loop types.
• Quantitative correlation between loop complexity, insertion time, and fatigue metrics.
• Direct applicability to ergonomic and occupational health improvements in endoscopy.
Limitations:
• Single-operator study limits generalizability.
• Simulation model may not fully capture anatomical variability and real-world procedural stress.
• Small sample size; statistical power and inter-operator variability not addressed.
Recommendations:
1. Manuscript refinement: Emphasize novelty and clinical relevance, particularly the practical applications for ergonomic device design and occupational safety protocols.
2. Future research: Recommend multi-operator studies to validate muscle activation patterns across experience levels and real-world procedures.
3. Ergonomic integration: Suggest incorporating findings into colonoscopy training programs and device evaluation to reduce repetitive strain injuries.
4. Data visualization: Consider additional heatmaps or muscle activation timelines to highlight asymmetry and fatigue progression, enhancing interpretability for clinicians.
Overall Assessment:
The study provides valuable, objective biomechanical data supporting ergonomic improvements in colonoscopy. With minor clarifications and broader context regarding clinical translation, this manuscript is suitable for publication in this journal focusing on endoscopy, and also journals directing occupational health, or medical ergonomics.
"
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Wang RG, Wang YQ, Cao H. Bilateral upper limb surface electromyography analysis during single-operator colonoscopy: Implications for ergonomics and occupational health. World J Gastrointest Endosc 2026; 18(3): 116646
20
"Summary:
This retrospective cross-sectional study evaluated 801 patients with inoperable esophageal malignancies undergoing ..."
[Read more]
"Summary:
This retrospective cross-sectional study evaluated 801 patients with inoperable esophageal malignancies undergoing self-expandable metallic stent (SEMS) placement using the vertebral column and diaphragm as fluoroscopic landmarks. Patients ranged from 18–95 years (mean 50 ± 15), with 50.9% female. Dysphagia was the presenting symptom (mean duration 3.84 months), and squamous cell carcinoma was the predominant histology (74.16%). Tumors most commonly involved the middle third of the esophagus, and inoperability was primarily due to distant metastases (52.81%). Tracheoesophageal fistula was present in 6%, and the mean stricture length was 8.4 cm. Pre-stent dilatation was required in 17.4% of patients. SEMS lengths ranged from 8–18 cm. The landmark-based technique achieved 100% technical success without major immediate adverse events. Repeat interventions were minimal (1.87% re-stenting for tumor overgrowth; 1.37% dilatation for tumor ingrowth).
Reviewer Comments:
Strengths:
*Large patient cohort with comprehensive demographic and tumor characteristics.
*Clear demonstration of technical feasibility and safety of landmark-based SEMS placement.
*Low rates of immediate complications and repeat interventions indicate procedural reliability.
Limitations:
*Retrospective design limits causal inference and generalizability.
*Lack of comparative data with conventional SEMS placement techniques.
*No formal assessment of patient-reported outcomes (e.g., dysphagia relief scores, quality of life).
*Long-term stent patency and survival data are not reported.
Recommendations:
*Consider prospective, comparative studies to validate the landmark-based approach against standard techniques.
*Include standardized patient-centered outcomes (dysphagia scoring, nutritional status, and quality of life).
*Explore the applicability of this technique in anatomically complex or upper esophageal tumors.
*Discussion could be strengthened by addressing limitations related to stent type, tumor morphology, and fluoroscopic variability.
Overall Assessment:
The study presents a practical, reproducible technique for SEMS placement using vertebral and diaphragmatic landmarks with excellent technical success. The findings are clinically relevant, particularly for high-volume centers performing palliative esophageal stenting. Future prospective studies are warranted to assess long-term outcomes and patient-centered benefits."
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Siyal M, Asim M, Qureshi S, Ghazanfar S, Siddiqui AR, Ahmed N, Altaf A, Zakaria N, Yaseen A, Kakar F, Kadir S, Hasan MK, Niaz SK. Navigating self-expandable metallic stent placement in inoperable esophageal malignancies: A landmark-based technique using the vertebral column and diaphragm. World J Gastrointest Endosc 2026; 18(3): 116060
15985 items Read more >>
Peer-Reviewers and Manuscript Statistics
- Editorial board members
- 2263
- Peer-reviewers
- 36923
- Manuscripts received today
- 5
- Manuscript reviews today
- 13
- Unhandled manuscripts today
- 168
- Active peer-reviewers today
- 4369
- Reviewer acceptance today
- 39
- Reviewer refusals today
- 41
- Total accepted manuscripts
- 41043
- Total rejected manuscripts
- 45249
- Total peer-reviewers
- 4772771
- Total submissions
- 38710
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1
"Chronic radiation proctitis (CRP) is a common delayed complication following pelvic radiotherapy, among which refractory bleeding ..."
[Read more]
"Chronic radiation proctitis (CRP) is a common delayed complication following pelvic radiotherapy, among which refractory bleeding is one of the most challenging issues. Currently, effective oral drugs are lacking, and treatment mostly relies on endoscopic argon plasma coagulation (APC), enema preparations, or surgery, which are associated with high recurrence rates and significant invasiveness. Therefore, exploring safe and effective oral therapeutic agents holds important clinical value. This study focuses on thalidomide, an old drug with anti-inflammatory, immunomodulatory, and anti-angiogenic properties, for the treatment of refractory hemorrhagic CRP, filling a gap in clinical data on oral medications in this field. "
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Huang XY, Zhong QH, Kuang YY, Li ZJ, Huang BJ, He YJ, Zhu MM, Guan Q, Li XY, Qin QY, Ma TH. Thalidomide for refractory hemorrhagic chronic radiation proctitis secondary to pelvic malignancy radiotherapy: A phase II clinical trial. World J Gastroenterol 2026; 32(14): 116529
2
"This cohort study has provided a review on the pediatric gastroenterology disease using genomic methods in Middle Eastern area. Hope ..."
[Read more]
"This cohort study has provided a review on the pediatric gastroenterology disease using genomic methods in Middle Eastern area. Hope that the flowchart to collect the proper cases in this study can be explained in view of author's efforts. In addition, the total candidate patients number may be added for solid foundation if possible. "
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Alsarhan A, Alloush R, Jain R, Abou Tayoun A, Tzivinikos C. Clinical utility of genomic investigations in a Middle Eastern pediatric gastroenterology disease cohort. World J Gastroenterol 2026; 32(13): 115810
3
"The article is written at a high scientific level. The research topic is relevant and in demand. The study design is described in ..."
[Read more]
"The article is written at a high scientific level. The research topic is relevant and in demand. The study design is described in detail and fully meets its stated objectives. The statistical methods used are sound and enable an adequate evaluation of the results obtained. The data obtained are clearly presented in both tabular and graphical forms. The discussion of the obtained data is logical, and the resulting conclusions are well-reasoned. The only caveat: for an article of this caliber, more references to sources from recent years would be desirable – in this case, of the 44 references, only 50% are from the last five years. "
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Wang XY, Yin KH, Cheng L, Wang XY, Qiao Y, Tang XR, Wang B, Yan XJ, Chen SL. Efficacy and safety of lansoprazole combined with flupentixol-melitracen for functional dyspepsia: A randomized, double-blinded, placebo-controlled clinical trial. World J Gastroenterol 2026; 32(13): 117115
4
"The important value of this study lies in its clear finding that lean MASLD patients show no statistically significant differences ..."
[Read more]
"The important value of this study lies in its clear finding that lean MASLD patients show no statistically significant differences from non-lean MASLD patients in terms of MASH, cardiovascular disease, and mortality risk, while their risks of cirrhosis, hypertension, and liver fibrosis are actually lower. The core clinical implication of this finding is that normal BMI should not be a reason to relax screening and risk assessment for MASLD and its complications. Of course, the study also has limitations: the definition of 'lean' varies across studies, which may introduce classification bias; and some outcomes (e.g., mortality, MASH, fibrosis) show high heterogeneity (I² > 90%), requiring cautious interpretation. Nevertheless, this is a study with direct practical guidance for clinical practice, particularly suitable for readers in hepatology, cardiology, endocrinology, and general medicine, as it helps shift MASLD screening strategies from an obesity-centered approach to multidimensional metabolic risk assessment. "
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Mapouka M, Pabingui E, Tazinkeng NN, Gurmessa M, Vickos U, Ndemazie NB, Camengo Police SM. Outcomes of liver and cardiovascular metabolic diseases among lean vs non-lean individuals with metabolic dysfunction-associated steatotic liver disease. World J Gastroenterol 2026; 32(13): 114657
5
"The authors integrated multiple GEO datasets, combined bioinformatics methods such as WGCNA and LASSO, and identified four ..."
[Read more]
"The authors integrated multiple GEO datasets, combined bioinformatics methods such as WGCNA and LASSO, and identified four exercise-responsive skeletal muscle genes (LAMA4, PECAM1, PXDN, THBS4), which were subsequently validated in an animal model. The study is clear in its approach and logically coherent. Its value lies in moving beyond the general attribution of exercise-induced improvement in MASLD to simply weight loss or metabolic improvement, instead attempting to pinpoint specific molecular mediators from the perspective of muscle–liver crosstalk. In particular, the detectability of PECAM1 and THBS4 in serum suggests their potential as liquid biopsy biomarkers or myokine-like candidates, offering reference value for the future development of exercise-mimetic drugs or precision intervention strategies. "
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Zhang JH, Chen K, Zhu XM, Zhou H, Jiang JM, Zou YQ, Liu KR, Zhang L, Li Y. Exercise-responsive skeletal muscle genes mechanistically linked to metabolic dysfunction-associated steatotic liver disease. World J Gastroenterol 2026; 32(13): 113985
6
"This is a well-organized and potentially meaningful study investigating exercise-responsive skeletal muscle biomarkers in MASLD. The ..."
[Read more]
"This is a well-organized and potentially meaningful study investigating exercise-responsive skeletal muscle biomarkers in MASLD. The integration of multiple GEO datasets, combined with WGCNA, LASSO modeling, validation cohort analysis, and animal experiments, represents a comprehensive approach. The identification of candidate genes involved in muscle-liver communication is of interest and may contribute to a better understanding of the mechanisms underlying the beneficial effects of exercise in MASLD. Nevertheless, one issue should be clarified. In the “Identification of DEGs” section and in Figure 1, the authors indicate that GSE161749, GSE48278, GSE156247, and GSE53598 were included. However, in Figure 2A/2B, the PCA legend appears to include GSE72462 instead of GSE156247. Please clarify which dataset was actually used and correct the figure or text accordingly. "
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Zhang JH, Chen K, Zhu XM, Zhou H, Jiang JM, Zou YQ, Liu KR, Zhang L, Li Y. Exercise-responsive skeletal muscle genes mechanistically linked to metabolic dysfunction-associated steatotic liver disease. World J Gastroenterol 2026; 32(13): 113985
7
"The gut–muscle axis shares its conceptual underpinnings with the gut–lung axis, encompassing bidirectional crosstalk driven by gut ..."
[Read more]
"The gut–muscle axis shares its conceptual underpinnings with the gut–lung axis, encompassing bidirectional crosstalk driven by gut dysbiosis, microbial translocation, immune dysregulation, and epigenetic modification. Short-chain fatty acids (SCFAs) — most notably butyrate — serve as the principal metabolic intermediary, promoting skeletal muscle protein synthesis and mitochondrial integrity through FFAR2/FFAR3 receptor signaling, AMPK–PGC-1α pathway activation, and PI3K/Akt/mTOR-mediated anabolism, while simultaneously exerting epigenetic regulation via histone deacetylase (HDAC) inhibition. A mechanistically distinctive feature of the gut–muscle axis is robust retrograde signaling from muscle to gut. Exercise-derived lactate directly fuels SCFA-producing bacteria, and muscle-secreted myokines actively modulate microbial diversity — thereby constituting an actionable, bidirectional feedback loop with no clear counterpart in the gut–lung axis. Furthermore, gut microbiota-derived secondary bile acids activate farnesoid X receptor (FXR) and Takeda G protein-coupled receptor 5 (TGR5) in skeletal muscle, representing a pathway of particular relevance to gut–muscle biology. Clinically, dysbiosis-driven SCFA depletion accelerates sarcopenia in aging populations, whereas patients with inflammatory bowel disease (IBD) face compounded muscle wasting attributable to chronic inflammation and nutrient malabsorption. Therapeutic strategies — encompassing probiotics, fecal microbiota transplantation (FMT), and butyrate supplementation — mirror those proposed for the gut–lung axis, with multi-omics integration and AI-driven analytics defining the shared frontier of precision medicine. In summary, the gut–muscle axis both extends and substantively complements the gut–lung axis paradigm. Crucially, physical activity emerges as a uniquely potent bidirectional therapeutic modality, making it particularly suited for addressing muscle wasting in IBD and aging populations. "
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Huang HJ, Liu PP, Dong DF. Research progress on comorbidity between gastrointestinal and pulmonary diseases from the perspective of the gut-lung axis. World J Gastroenterol 2026; 32(11): 115846
8
"I thank Khan et al for conducting this meta-analysis and finding out that hypoalbuminemia is a risk factor for mortality in ..."
[Read more]
"I thank Khan et al for conducting this meta-analysis and finding out that hypoalbuminemia is a risk factor for mortality in cholangitis. I have a few comments that have to be taken into account while interpreting this study. First, this meta-analysis includes only retrospective studies. Second, there is no subgroup analysis by benign versus malignant aetiology of acute cholangitis. The outcomes of cholangitis depend on aetiology, which is not studied. This indicates whether hypoalbuminemia is due to cholangitis as an acute-phase reactant, or whether any underlying aetiology needs to be identified. Whether any intervention in acute cholangitis with hypoalbuminemia has any role in the outcome has not been studied. However, this meta-analysis provides meaningful research questions for future prospective studies. "
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Khan RTY, Ahsam S, Kumar SK, Khan K, Kakar MT, Hyder A, Malik W, Mubarak M, Luck NH. Hypoalbuminemia as a predictor of mortality in patients with acute cholangitis: A systematic review and meta-analysis. World J Gastrointest Pathophysiol 2026; 17(1): 113373
9
"Sheriefet al. [1]demonstrated dual parametric evaluation to assess diagnostic performance for Hepatocellular carcinoma (HCC), ..."
[Read more]
"Sheriefet al. [1]demonstrated dual parametric evaluation to assess diagnostic performance for Hepatocellular carcinoma (HCC), discriminating from Hepatitis C-related liver Cirrhosis and Healthy control cohorts via plasma in a single centred Egyptian population.This study [1] revealed two leading biomarkers with exceptional accuracy (AUC >0.99); hsa-miR-21-5p (Sensitivity and Specificity of 98.6% and 96.7%, respectively) and Leukocyte-associated immunoglobulin-like receptor-1(LAIR-1) mean fluorescence intensity (MFI) (Sensitivity and Specificity of 100 % and 98.3%, respectively). Sherief et al. [1]aims to address one of the clinically challenging issues i.e. lack of sensitive, specific circulatory biomarker/s for early diagnosis of Hepatocellular Carcinoma (HCC).Commentary noted several strengths of the study by Sherief et al. [1],such as; looks technicallymoderatein study design, methodology and innovation level i.e. prospective study, minimally invasive sample collection, exploration of dual parameters: tumour derived circulatory micro-RNA and immune related marker. Additionally, study employed rigorous statistical analysis for diagnostic performance assessment including ROC curve analysis, comparative Sensitivity/Specificity,revealed promising findings that may pave for future research towards biomarkers validation and discovery. However,present commentary observed several concerns for the study by Sherief et al. [1]; (i) Lack of mechanistic cascade exploration including causal pathway/s.(ii) Median age of HCC cohort is significantly higher than Hepatitis C-related liver Cirrhosis and Healthy control, may be a biasing factor in expression pattern. (iii) Since study did not include follow up subjects that limits for probing of prognostic markers. (iv) Paucity of multi-centric involvement for diversified population, may limit the findings for generalized conception. (v) Validation of findings through blinded samples may demonstrate a better decision regarding applicability. (vi) Authors used word ‘noninvasive’, for plasma-based markers investigation(vii) Global Cancer statistics 2022,wasalready published in 2024[2], still authors used GLOBOCON 2020 [3] reference in epidemiological outline in the manuscript [1], latest reference can provide contemporary status. The article by Sherief et al. [1], demonstrated balanced and structured scientific contents along with logical explanations. However, addition of graphical abstract to present the study in nutshell may improve the visibility for readers. A large sample sized, multi-centered,longitudinal study, involving diversified geographical and ethnic population of HCC, Hepatitis C-related liver Cirrhosis, Healthy control cohorts, and mechanistically relevant subgroups, using common protocol, validation through blinded samples, may provide potential edge for HCCdiagnosticsto achieve common consensus and identification of prognostic biomarkers. Integrated nomogram ofhsa-miR-21-5p with LAIR-1 MFI, may be explored for possible better diagnosticsetup. Application of Artificial Intelligence (AI) may be explored for diagnostic performance as well as high throughput outcomes. References: 1. Sherief DE, Shehata HH, Nosair N, Othman AAA, Sadaka E, Elgamal R. Dual-parameter liquid biopsy using plasma miR-21-5p and T cell LAIR-1 mean fluorescence intensity for hepatocellular carcinoma diagnosis in a high-risk Egyptian cohort. World J Gastrointest Oncol 2026 March 15a; 18(3): 116567. 2. Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, Jemal A. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for36 cancers in185 countries. CA Cancer J Clin. 2024; 74:229–263 3. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin 2021; 71: 209-249 "
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Sherief DE, Shehata HH, Nosair N, Othman AAA, Sadaka E, Elgamal R. Dual-parameter liquid biopsy using plasma miR-21-5p and T cell LAIR-1 mean fluorescence intensity for hepatocellular carcinoma diagnosis in a high-risk Egyptian cohort. World J Gastrointest Oncol 2026; 18(3): 116567
10
"I read with ken interest about the following article. As a reader I have few comments/ suggestions also. Alok Bharadwaj, Manas Taneja, ..."
[Read more]
"I read with ken interest about the following article. As a reader I have few comments/ suggestions also. Alok Bharadwaj, Manas Taneja, Sneha Dubey, Aditya Saxena. Very low-density lipoprotein and the human health. World J Exp Med 2026;16(1): 117024 [DOI: 10.5493/wjem.v16.i1.117024] Abstract Apo B100, TGL and cholesterol are present in LDL in addition to VLDL. But the ratio of TGL: cholesterol may vary. PATHOLOGICAL ROLE OF VLDL: Metabolism-associated fatty liver disease and liver disease: Distinction between NAFLD, MAFLD and MASLD may be provided Following the classification of metabolic dysfunction-associated fatty liver disease (MAFLD), non-alcoholic fatty liver disease (NAFLD) has recently been redefined again as metabolic dysfunction-associated steatotic liver disease (MASLD). Both MASLD and MALFD were linked to higher all-cause mortality risk, but MASLD identified a greater number of individuals compared to MAFLD. (Song R, Li Z, Zhang Y, Tan J, Chen Z. Comparison of NAFLD, MAFLD and MASLD characteristics and mortality outcomes in United States adults. Liver Int. 2024;44:1051-1060. doi:10.1111/liv.15856) Metabolic-associated fatty liver disease (MAFLD) exhibits a raised VLDL secretion rate attributed to increased intrahepatic TGs hydrolysis. They apparent the absence of immediate VLDL secretion reduction yet maintained a consistent apo B100 secretion rate, as informed by previous studies/ I would like to reframe this sentence: in the presence of elevated counter-regulatory hormones, lipolysis takes place in the adipose tissue releasing free fatty acids into circulation. Majority of these fatty acids are take up liver and converted into triglycerides. If VLDL secretion from liver is not proportionate to the level of fatty acid entry into liver, fatty acids may get accumulated in the liver causing different forms of fatty liver. In individuals with insulin resistance and higher body weight, there is an elevation in apo C-III levels within VLDL. Apo CIII is an inhibitor of lipoprotein lipase, thus inhibiting lipolysis of TGL in VLDL, thus increasing VLDL concentration in blood. Insulin resistance and MetS Insulin-hampered VLDL production, along with insulin resistance, leads to increased and decreased production of VLDL, often associated with hypertriglyceridemia Does VLDL increase or decrease with insulin resistance Hepatic VLDL production is decreased by glucagon Mechanism behind this Alterations of VLDL in various disorders have been explained well. All the mechanistic pathways have been adequately addressed "
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Bharadwaj A, Taneja M, Dubey S, Saxena A. Very low-density lipoprotein and the human health. World J Exp Med 2026; 16(1): 117024
11
"This letter to the Editor notes the potential significance of clinical situation in patients who suffer from emphysematous ..."
[Read more]
"This letter to the Editor notes the potential significance of clinical situation in patients who suffer from emphysematous pyelonephritis. This is very important. Clinical findings and symptoms must be the cornestone in these conditions in order to avoid the worse outcomes of patients. In addition, the Modified National Early Warning Score 2 based on physiological situation of patient shoud be very helpfull, as well as computed tomography findings. "
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Sevik C, Erbin A, Canat HL. Integrating Modified National Early Warning Score 2, computed tomography staging, and laboratory markers for enhanced prognostic stratification in emphysematous pyelonephritis. World J Nephrol 2026; 15(1): 113952
12
"This manuscript defined as Editorial is generally good, but it mildly offers new lights in concept of diabetic nephropathy ..."
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"This manuscript defined as Editorial is generally good, but it mildly offers new lights in concept of diabetic nephropathy complications and its progression in death. Pathophysiology paragragh is better than the other parts of manuscript. Addiotionally, inequalities and differences between racial and ethic groups were noted, which is not usual in other published manuscripts. "
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Gembillo G, Ricca MF, Santoro D. Diabetes-related renal complications: Insights on the impact of diabetic kidney disease on mortality. World J Nephrol 2026; 15(1): 108432
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"Reader’s code: 00106360 Commentary on the Article Impact of metabolic dysfunction-associated steatotic liver disease on liver ..."
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"Reader’s code: 00106360 Commentary on the Article Impact of metabolic dysfunction-associated steatotic liver disease on liver metastasis and survival in pancreatic cancer The study by Chon HY et al. examines the impact of metabolic dysfunction-associated steatotic liver disease (MASLD) on liver metastasis and survival in patients with Pancreatic Ductal Adenocarcinoma. Using a large retrospective cohort of 2123 patients, the authors assessed hepatic steatosis primarily through the hepatic steatosis index (HSI) and additionally validated findings using CT-based measurements of liver fat. The study found no significant association between MASLD and the presence of liver metastasis at diagnosis or during follow-up, suggesting that hepatic steatosis may not be a key determinant of metastatic spread in pancreatic cancer (Chon et al., 2026). The findings contrast with previous research in other malignancies, such as colorectal and breast cancers, where hepatic steatosis has been reported to influence liver metastasis risk or metastasis-free survival (van Saane et al., 2019; Wu et al., 2020). In the present study, tumor size and elevated CA19-9 levels were the main predictors of liver metastasis, while diabetes mellitus was associated with improved survival outcomes, possibly reflecting earlier detection among diabetic patients (Chon et al., 2026). Critical Appraisal of the Study The study by Chon HY and colleagues evaluates the relationship between metabolic dysfunction-associated steatotic liver disease (MASLD) and liver metastasis in patients with Pancreatic Ductal Adenocarcinoma. Using a large retrospective cohort of 2123 patients, the authors investigated whether hepatic steatosis, measured by the hepatic steatosis index (HSI), influences the development of liver metastasis and overall survival. Strengths One of the major strengths of this study is its large sample size and long study period (2006–2021), which enhances the statistical power and reliability of the findings. The authors used robust statistical methods, including logistic regression and Cox proportional hazards models, to analyze risk factors for both baseline and newly developed liver metastases. Another notable strength is the additional CT-based validation in a subgroup of patients, which helps corroborate the HSI-based assessment of hepatic steatosis. The study also carefully adjusted for multiple potential confounders such as age, BMI, diabetes, lipid profile, tumor size, and CA19-9 levels. Limitations Despite these strengths, several limitations should be considered. First, the retrospective design limits the ability to establish causal relationships. Second, the primary assessment of hepatic steatosis relied on the HSI, an indirect surrogate marker derived from BMI and liver enzyme ratios, which may be influenced by cancer-related factors such as cachexia, inflammation, or biliary obstruction. Third, important pathological variables (e.g., lymph node status, lymphovascular invasion, and perineural invasion) were not consistently available and therefore could not be included in the multivariate models. Additionally, the CT-based validation was limited to a subset of patients, which may introduce selection bias. Clinical Implications Clinically, the findings suggest that MASLD may not be a significant determinant of liver metastasis in pancreatic cancer, contrasting with observations in other malignancies. Instead, established markers such as tumor size and elevated CA19-9 levels appear to remain more reliable predictors of metastatic risk and mortality. These results highlight the aggressive biological behavior of pancreatic cancer, where tumor-driven mechanisms may outweigh the influence of underlying hepatic metabolic conditions. Future prospective studies incorporating advanced imaging, histologic confirmation, and molecular analysis of the tumor–liver microenvironment are needed to further clarify the role of MASLD in pancreatic cancer progression. Despite its strengths, including a large sample size and robust statistical modeling, the retrospective design and reliance on HSI rather than histologic confirmation limit the ability to establish causality. Nevertheless, this study contributes important evidence suggesting that the relationship between MASLD and metastasis may be cancer-specific and biologically complex. Reference Chon HY, Rhee H, Kim J, et al. Impact of metabolic dysfunction-associated steatotic liver disease on liver metastasis and survival in pancreatic cancer. World Journal of Gastroenterology. 2026;32(11):115488. van Saane AM, et al. Non-alcoholic fatty liver disease and colorectal liver metastasis risk. Liver International. 2019. Wu W, et al. Hepatic steatosis and liver metastasis-free survival in breast cancer. Cancer Medicine. 2020. "
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Chon HY, Rhee H, Kim J, Leem G, Jo JH, Chung MJ, Park JY, Bang S, Park SW, Kim SU, Lee HS. Impact of metabolic dysfunction-associated steatotic liver disease on liver metastasis and survival in pancreatic cancer. World J Gastroenterol 2026; 32(11): 115488
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"Esophageal variceal bleeding is one of the most severe complications of cirrhotic portal hypertension, associated with high rates ..."
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"Esophageal variceal bleeding is one of the most severe complications of cirrhotic portal hypertension, associated with high rates of rebleeding and mortality. Although endoscopic variceal band ligation (EVBL) is currently the standard treatment, its reliance on repeated endoscopic follow-up presents challenges, including invasiveness, high resource consumption, and poor patient tolerance. This study focuses on the potential application of multiparametric ultrasound (MP-US) in predicting outcomes following EVBL, proposing a novel follow-up strategy that is noninvasive, individualized, and reproducible, with significant promise for clinical translation. The article begins with the clinical burden of EVB, progressively introduces the limitations of current diagnostic and therapeutic approaches, and naturally transitions to the technical advantages and research evidence supporting MP-US, culminating in future research directions. The structure is well-organized, and the logic is rigorous. The critical analysis of existing technologies is insightful. The article objectively highlights the limitations of HVPG and repeated endoscopy, particularly their inaccessibility in resource-limited settings. It also provides a reasonable evaluation of the shortcomings of noninvasive tools such as the Baveno criteria and elastography in predicting postprocedural outcomes, reflecting the authors' deep understanding of clinical realities. The analysis of MP-US's clinical application is thorough. By integrating measurements of liver stiffness, spleen stiffness, and perfusion imaging, MP-US enables a comprehensive assessment of portal hypertension from both structural and hemodynamic perspectives, overcoming the limitations of traditional single-parameter prediction models. Citing data from Ainora et al, the study demonstrates the potential of MP-US in predicting variceal eradication and guiding individualized follow-up. The outlook on future research directions is instructive. The article notes that current studies are mostly small-sample, single-center designs lacking standardized operating and interpretation protocols, and calls for multicenter, prospective studies to validate the clinical value of MP-US—a recommendation with practical significance. Figure 1 is highly informative, clearly illustrating the evolutionary pathway from invasive to noninvasive diagnostic tools, facilitating readers' understanding of technological advancements. Areas for improvement and suggestions: The issue of MP-US technical standardization requires further clarification. Although the article mentions that MP-US is influenced by factors such as operator experience and equipment variability, it does not delve deeply into how to achieve standardized operation and interpretation; future research should focus on this aspect. A cost-effectiveness analysis is lacking. While MP-US has the potential to reduce the frequency of endoscopic examinations, its high equipment costs and reliance on contrast agents may limit its widespread adoption in certain regions. Future studies should incorporate health economic evaluations. The integration of AI with MP-US warrants further exploration. The article mentions the application of AI in endoscopic measurement but does not explore the possibility of combining AI with MP-US. Future research could investigate AI-based automated analysis of MP-US images and risk prediction models. This study, with its clear logic, solid literature support, and forward-looking perspective, systematically elaborates on the potential application of MP-US in post-EVBL follow-up. It not only provides clinicians with new diagnostic and therapeutic insights but also points future researchers toward promising directions. If further advancements are made in MP-US standardization, multicenter validation, and AI integration, it holds the potential to achieve truly noninvasive, precise, and individualized management of portal hypertension in patients with cirrhosis. "
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Martínez-Díaz FM, Jiménez-Cuevas EA, Morales-Galicia AE, Ramírez-Mejía MM, Qi XS, Poo JL, Méndez-Sánchez N. Toward noninvasive prediction of treatment outcomes in patients with variceal bleeding. World J Gastroenterol 2026; 32(11): 115723
15
"This systematic review of 8 randomized trials (1758 participants) rigorously evaluates adjunctive pharmacotherapies for diuretic ..."
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"This systematic review of 8 randomized trials (1758 participants) rigorously evaluates adjunctive pharmacotherapies for diuretic resistance in acute decompensated heart failure (ADHF), adhering to PRISMA guidelines and using Cochrane’s RoB 2.0 for bias assessment. Key findings show proximal nephron-targeted agents (acetazolamide, SGLT2 inhibitors) and distal thiazide diuretics effectively boost decongestion: acetazolamide raises successful decongestion rates (42.2% vs 30.5%), SGLT2 inhibitors enhance urine output and reduce worsening HF, while thiazides prompt greater weight loss but increase renal dysfunction risk. Notably, older agents (high-dose spironolactone, low-dose dopamine/nesiritide) yield no meaningful clinical benefits. The review’s strength lies in its exclusive focus on randomized trials, but heterogeneity in endpoints and short follow-up limit generalizability. It provides a mechanistically guided, stepwise clinical framework for ADHF management, emphasizing personalized adjunct selection, and identifies the need for large head-to-head trials and long-term outcome research to address existing evidence gaps. "
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Patel V, Zameer R, Kumar B, Das M. Adjunctive pharmacologic therapies for diuretic resistance in acute decompensated heart failure: Systematic review of randomized trials. World J Meta-Anal 2026; 14(1): 118496
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"The article raises critical issues regarding healthcare expenditure and the anesthesiologist’s responsibility in cost containment. ..."
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"The article raises critical issues regarding healthcare expenditure and the anesthesiologist’s responsibility in cost containment. While the narrative is informative, a more quantitative economic comparison and inclusion of updated guidelines or contemporary practice data would strengthen the conclusions. Additionally, deeper exploration of medico-legal concerns and institutional resistance could enhance its practical impact. Nevertheless, the review addresses a clinically meaningful topic. "
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Karim HMR. Healthcare delivery cost and anesthesiologists: Time to have a greater role and responsibility. World J Anesthesiol 2019; 8(3): 19-24
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"I read with great interest the study by Khalifa et al. published in the World Journal of Orthopedics, evaluating the impact of surgeon ..."
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"I read with great interest the study by Khalifa et al. published in the World Journal of Orthopedics, evaluating the impact of surgeon handedness on radiological and functional outcomes following primary total knee arthroplasty (TKA). The authors should be commended for addressing an underexplored yet clinically relevant surgeon-related variable in arthroplasty practice. The finding that overall limb alignment and functional outcomes were not significantly influenced by operating on the dominant versus non-dominant side is reassuring. However, the increased incidence of tibial component malalignment (MPTA outliers) on the non-dominant side highlights an important technical nuance that may have implications for implant longevity, particularly in mechanically aligned TKA performed with conventional instrumentation. The subgroup analysis comparing intramedullary and extramedullary tibial guides is particularly interesting, suggesting that technique selection may interact with laterality. These findings underscore the potential value of ergonomic optimization and heightened intraoperative vigilance when operating on the non-dominant side. Future prospective studies incorporating sagittal and rotational alignment parameters, inclusion of left-handed surgeons, and long-term survivorship data would further clarify the clinical significance of these observations. Additionally, evaluating whether navigation or robotic assistance mitigates the subtle asymmetries associated with surgeon handedness could provide valuable insights. Overall, this study contributes meaningfully to the ongoing discussion regarding modifiable surgeon-related factors influencing TKA precision and outcomes. "
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Khalifa AA, Abdelaal AM, Moustafa MM. Does surgeon handedness affect the outcomes after primary total knee arthroplasty? A retrospective cohort study. World J Orthop 2026; 17(2): 113696
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"I would like to congratulate the authors on this clinically relevant study. The authors provided a conclusion that differs from ..."
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"I would like to congratulate the authors on this clinically relevant study. The authors provided a conclusion that differs from previously published results. ETV is generally considered renal-neutral and is commonly used in DCLD due to its renal safety. The statement that ETV is associated with a greater decrease in GFR than TMV is overfitting, as it is a retrospective study. The Difference in decline of approximately 4 mL/min/1.73 m² is very small and may not be clinically meaningful in patients with normal GFR, even though it is statistically significant. The conclusion should be interpreted with caution and requires additional long-term prospective studies to substantiate this claim. Furthermore, the authors did not report any additional adverse events during the study period. "
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Ma SP, Wang L, Zhang YL, Wan X, Liu Q, Tang YL, Malhi LR, Ge SF. Effects of tenofovir amibufenamide and entecavir on estimated glomerular filtration rate in treatment-naïve patients with chronic hepatitis B. World J Hepatol 2026; 18(2): 114346
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"I congratulate the authors on this relevant study on this study. As the authors pointed out, Klebsiella is the leading cause of liver ..."
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"I congratulate the authors on this relevant study on this study. As the authors pointed out, Klebsiella is the leading cause of liver abscesses in Asia and is increasingly prevalent in India. It is important to have culture reports at various time points, as they will help us in deciding empirical antibiotics. The authors have shown that the isolated organisms are highly resistant to ampicillin and have low resistance to cephalosporins and carbapenems. With this large amount of data, the authors would have identified the poor prognostic predictors of PLA and treatment outcome. The authors did not present the data on complications of these abscess such as biliary fistula "
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Mai-Phan TA, Thai KP, Le KL, Pham TN, Tran MQ, Pham PC, Duong NNQ, Trinh MT, Le NK. Klebsiella pneumoniae as leading cause of pyogenic liver abscess: Three years study in Southern Vietnam. World J Hepatol 2026; 18(2): 113695
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"Wang and Pan present an editorial that meaningfully extends the discussion of ERAS in elderly gastric cancer patients beyond ..."
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"Wang and Pan present an editorial that meaningfully extends the discussion of ERAS in elderly gastric cancer patients beyond feasibility toward biologically grounded recovery. Building on prior evidence by Li et al. demonstrating the safety and protocol adherence of ERAS in older adults. The authors appropriately emphasize physiological heterogeneity, frailty, and resilience as key determinants of postoperative outcomes rather than chronological age alone. The proposed multidomain framework integrating nutritional inflammatory balance, circadian regulation, psychological resilience, and digital monitoring, offers an important conceptual advance. However, many of these strategies rely on resource intensive multidisciplinary teams, biomarker surveillance, and wearable technologies, which may limit generalizability outside high-volume or well-resourced centers. Future efforts may benefit from parallel development of simplified, scalable ERAS adaptations for elderly patients. Overall, this editorial provides a valuable roadmap for evolving ERAS from protocol compliance toward patient-centered, biologically informed recovery in an aging surgical population. "
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Wang G, Pan SJ. From feasibility to biological recovery: Reframing enhanced recovery pathways after surgery in elderly gastric cancer patients. World J Gastroenterol 2026; 32(7): 116264
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