Baishideng Publishing Group

Wei MX, Lei LL, Xu RH, Liu YX, Wang R, Han WL, Fan ZM, Xiao FK, Sheyhidin I, Ma L, Ku JW, Yin MZ, Ji AF, Bao QD, Gao SG, Han XN, Li XM, Chen PN, Zhao XK, Song X, Wang LD. Ethnic genomic differences in esophageal squamous cell carcinoma: Whole-exome sequencing of Han and Kazakh populations in China. World J Gastroenterol 2025; 31(46): 112664

"The peer review process was efficient and the reviewers provided detailed and constructive feedback that significantly improved the ..." [Read more]

"The peer review process was efficient and the reviewers provided detailed and constructive feedback that significantly improved the clarity, methodology, and overall quality of our manuscript. We appreciate the transparency of the review process and the timely communication from the editorial office. Thank you for your professional support throughout the publication workflow. " [Collapse]

Liu KT, Lee MH, Lin CH, Tsou YK, Sung KF, Wang SF, Wu CH, Liu NJ. Acute cholangitis due to common bile duct stones: Clinical outcomes in patients with and without concurrent acute pancreatitis. World J Clin Cases 2025; 13(32): 110553

"The editorial and publishing process for our manuscript (ID 106359) was clear, professional, and efficient from submission to ..." [Read more]

"The editorial and publishing process for our manuscript (ID 106359) was clear, professional, and efficient from submission to publication. Communication from the editorial office was timely and helpful throughout. The peer review process was constructive, and the revisions contributed to strengthening the final paper. The online submission system was straightforward to use. We are satisfied with our experience and appreciate the journal's role in disseminating our research. " [Collapse]

Ong B, See KC, Kim SS, Lau YH. Effectiveness of a noise reduction intervention in the intensive care unit: A prospective bicenter study. World J Crit Care Med 2025; 14(4): 106359

"We would like to thank the eminent journal (World Journal of Gastroenterology) for the great processing of our manuscript from the ..." [Read more]

"We would like to thank the eminent journal (World Journal of Gastroenterology) for the great processing of our manuscript from the starting point of topic invitation, to paper submission, to the fruitful and great peer review process, to the editing and production of our publication, and final publication of the manuscript. It was a satisfying, and great experience. " [Collapse]

El-Nakeep S, AbdelAziz H, Michael TG, ElGhandour AM, Abdelsattar HA, Awad FMR, Kasi A. Clinical utility of telomeres as diagnostic and short-term prognostic markers in loco-regional treatment of hepatocellular carcinoma. World J Gastroenterol 2025; 31(46): 112530

"World Journal of Gastrointestinal Pharmacology and Therapeutics was a positive experience overall for submitting my manuscript. The ..." [Read more]

"World Journal of Gastrointestinal Pharmacology and Therapeutics was a positive experience overall for submitting my manuscript. The online submission system was easy to navigate, the author guidelines were clear, and the editorial office was responsive and professional. The initial review timeline was reasonable, and I felt that the journal treated the work seriously and respectfully. I didn’t enjoy the revision process quite as much. While the reviewers’ comments were generally helpful, the back-and-forth felt a bit more cumbersome and drawn out than I’d hoped. Even so, communication from the editorial team remained courteous and organized, and the paper ultimately moved forward. I would still consider WJGPT a solid option, especially if you value a clear submission process and professional editorial handling. " [Collapse]

Mercola J. Targeted nanoliposomal nutrient delivery for human health. World J Gastrointest Pharmacol Ther 2025; 16(4): 111502

"It was a pleasure publishing with the journal. The only thing I feel is that the time between acceptance and publishing online was ..." [Read more]

"It was a pleasure publishing with the journal. The only thing I feel is that the time between acceptance and publishing online was a bit prolonged. The peer review and the remaining time intervals were perfect. It would be great if the editorial team could reduce the time to online publication. " [Collapse]

Zacharia GS, Ashraf MH, Sosa F, Jacob A, Patel H. Quick glance at 'metabolic dysfunction associated steatotic liver disease' therapeutics: Targets, trials, and trends. World J Gastrointest Pharmacol Ther 2025; 16(4): 110827

"As corresponding author of this article, I am especially proud of the rigorous and collaborative work led by Karen L. Ochoa and the ..." [Read more]

"As corresponding author of this article, I am especially proud of the rigorous and collaborative work led by Karen L. Ochoa and the main co-authors Amy G. Heredia, Camila C. Piedra, Reymonth J. Arias, and Bengy J. Ortiz, whose efforts in study design, data extraction, and critical synthesis were essential to the quality of this systematic review. I am sincerely grateful to the World Journal of Biological Chemistry for the invitation to contribute to this issue and for the careful, constructive peer-review process. We hope that our findings will foster new research at the intersection of periodontal infection and Alzheimer’s disease and look forward to future collaborations with the journal. " [Collapse]

Ochoa KL, Heredia AG, Piedra CC, Arias RJ, Ortiz BJ, Dominguez-Gortaire JA. Association between Alzheimer's disease and Porphyromonas gingivalis products in murine models: A systematic review. World J Biol Chem 2025; 16(4): 111156

"Dear Editor, We would like to congratulate you on the seriousness, transparency, and care demonstrated throughout the submission ..." [Read more]

"Dear Editor, We would like to congratulate you on the seriousness, transparency, and care demonstrated throughout the submission process. Your thoughtful and rigorous approach clearly reflected the journal’s commitment to continuously improving the quality of its publications, which made us feel that our work was genuinely respected and truly valued. Sincerely, Cristiane A Villela-Nogueira " [Collapse]

da Silva PGF, Barrocas JBP, Perazzo H, Villela-Nogueira L, Peixoto HR, Pereira GHS, Braga LNP, Chinzon M, de Silva JRL, Fernandes FF, Villela-Nogueira CA. Transient elastography and fibrosis-4 index as predictors of hepatocellular carcinoma in hepatitis C virus patients with sustained virological response. World J Gastroenterol 2025; 31(45): 112318

"nothing to saynothing to saynothing to saynothing to saynothing to saynothing to saynothing to saynothing to saynothing to saynothing ..." [Read more]

"nothing to saynothing to saynothing to saynothing to saynothing to saynothing to saynothing to saynothing to saynothing to saynothing to saynothing to saynothing to saynothing to saynothing to saynothing to saynothing to saynothing to saynothing to saynothing to saynothing to saynothing to saynothing to saynothing to saynothing to saynothing to saynothing to saynothing to saynothing to saynothing to saynothing to saynothing to saynothing to saynothing to say " [Collapse]

Fogas CR, Balassone V. Artificial intelligence in gastrointestinal endoscopy: Focus on analytical depth and endoscopist training. Artif Intell Gastrointest Endosc 2025; 6(4): 115140

"Excellent journal and managing team. Very efficient handling and processing. All in all a very smooth and effortlessly process. ..." [Read more]

"Excellent journal and managing team. Very efficient handling and processing. All in all a very smooth and effortlessly process. Hopefully will have many more publications in this very reputable journal. I hope the journal continues to achieve more success and the same be reflected in the ever improving journal metrics. Hope to contribute in all ways possible. " [Collapse]

Suresh MG, Mohamed S, Shanmugavel Geetha H, Sekar A, Prabhu S, Sargent J, Abraham GM, Hatwal J, Batta A, Mohan B. Prehospital aspirin use is associated with improved clinical outcomes in pulmonary embolism: A retrospective case-control study. World J Cardiol 2025; 17(11): 110178

"This was good and seamless process. Initially, the paperwork that I needed to submit was a bit confusing but we were able to figure ..." [Read more]

"This was good and seamless process. Initially, the paperwork that I needed to submit was a bit confusing but we were able to figure it out. Everyone on the editorial team was quick to respond, very professional. There was a great attention to detail. The peer review process was also fair and quick. It was a great experience working with F6Publishing. " [Collapse]

Nestoiter KG, Feick K, Looney K, Zaccheo M, Wert Y, Franz C. Critical care primary services are associated with reduced midazolam use in the intensive care unit. World J Crit Care Med 2025; 14(4): 111260

"I am writing to express my sincere appreciation for the exceptional handling of my manuscript (ID: 112926) throughout the publication ..." [Read more]

"I am writing to express my sincere appreciation for the exceptional handling of my manuscript (ID: 112926) throughout the publication process. I was thoroughly impressed by the professionalism, efficiency, and meticulous attention to detail demonstrated by the editorial team. The editor’s timely communications, constructive feedback, and thoughtful guidance significantly contributed to refining the paper and ensuring a smooth revision experience. Such dedication not only facilitated the acceptance of this work but also reinforced my confidence in submitting future research to your journal. Please accept my deepest gratitude for your outstanding support and unwavering commitment to maintaining high academic standards " [Collapse]

Ma HF, Chen YH, Wang Y, Zhang XC, Li JN, Wang YM, Zhou ZY. Complete blood counts and their derived inflammatory markers with anal fistulas in male children: A retrospective case-control study. World J Gastroenterol 2025; 31(45): 112926

"We would like to express our sincere gratitude to all the editorial staff for their professional guidance and meticulous assistance ..." [Read more]

"We would like to express our sincere gratitude to all the editorial staff for their professional guidance and meticulous assistance throughout the publication process. This has been an extremely satisfying and smooth experience, and we are truly looking forward to maintaining this positive partnership and collaborating with you on more projects in the future. " [Collapse]

Jiang C, Guan RN, Shu Y, Zhang L, Mao XP, Nie Q, Zhu HF. Impact of multidisciplinary nursing interventions and blood glucose control on diabetic foot ulcer healing, patient emotions, and satisfaction. World J Psychiatry 2025; 15(11): 106956

"We express our sincere gratitude to the editorial team for the transparent and efficient peer-review process, as well as for the ..." [Read more]

"We express our sincere gratitude to the editorial team for the transparent and efficient peer-review process, as well as for the opportunity to publish our work in the World Journal of Transplantation. We highly appreciate the professional approach, constructive feedback, and valuable support that helped us refine the manuscript and achieve successful publication. " [Collapse]

Semash K, Akhmedov A, Dzhanbekov T, Umarov Q, Dustmurodov J. Implementation of a pediatric kidney transplantation program in Uzbekistan: Feasibility and early outcomes. World J Transplant 2025; 15(4): 107728

"Thank you for providing a fair and objective system of peer review. We feel that the whole process from submission and publication ..." [Read more]

"Thank you for providing a fair and objective system of peer review. We feel that the whole process from submission and publication was done in appropriate time frame. Thank you to reviewers and editing team for making this possible. We hope to contribute more in this journal and f6 publishing system. " [Collapse]

Maqbool U, Raza MA, Maqbool A, Chaudhri S, Runau F. Trends in diverticular disease mortality among United States adults (1999–2020) by gender, race, and geographic region. World J Gastrointest Pharmacol Ther 2025; 16(4): 110559

"The Peer review and publication process of WJCCM has been seamless and excellent. The peer reviewers have looked for minute details ..." [Read more]

"The Peer review and publication process of WJCCM has been seamless and excellent. The peer reviewers have looked for minute details including referencing and Factual errors. The time gap from submission to publication is also relatively quick; despite such extensive peer review. Really satisfied with the process of Baishideng publishing grou and WJCCM Regards " [Collapse]

Mampilly AP, Chacko B, Mathew J, George K, Paul A, Jasmine S, George S, Gunasekaran K, Nanda R, Bansal V, Peter JV. Outcome predictors of systemic lupus erythematosus requiring admission to the intensive care unit. World J Crit Care Med 2025; 14(4): 108689

"nice work for peer review and all . I love the way they communicate with us and we have to submit it here. all the work is so organized ..." [Read more]

"nice work for peer review and all . I love the way they communicate with us and we have to submit it here. all the work is so organized that make me love the F6 publishing system. I hope that I can work more places and publish it here. It is very good for publishing in those journals and the peer review is good. system is easy and it can transfer so quickly. I hope that everything will be fine with to submit here and publish more articles " [Collapse]

Siddiqi AK, Shafiq A, Ahmed M, Anwer A, Maniya MT, Ahmed A, Chachar MA, Hasibuzzaman MA. Therapeutic use of music listening in patients undergoing invasive coronary procedures: A meta-analysis. World J Cardiol 2025; 17(1): 97406

"nice work for peer review and all . I love the way they communicate with us and we have to submit it here. all the work is so organized ..." [Read more]

Mathew R, Sapru K, Gandhi DN, Surve TAN, Pande D, Parikh A, Sharma RB, Kaur R, Hasibuzzaman MA. Impact of cognitive rehabilitation interventions on memory improvement in patients after stroke: A systematic review. World J Methodol 2025; 15(3): 98132

"nice work for peer review and all . I love the way they communicate with us and we have to submit it here. all the work is so organized ..." [Read more]

Sukaina M, Waheed M, Rehman S, Hasibuzzaman MA, Meghani R. Demographic trends in mortality with older population due to atrial fibrillation and flutter from 1999-2020. World J Cardiol 2025; 17(1): 99933

"To the Editorial Team of World Journal of Gastrointestinal Pharmacology and Therapeutics, I am writing to express my sincere gratitude ..." [Read more]

"To the Editorial Team of World Journal of Gastrointestinal Pharmacology and Therapeutics, I am writing to express my sincere gratitude for your meticulous handling of my manuscript entitled [Title of Manuscript]. Your rigorous peer-review process, insightful comments, and constructive suggestions significantly refined the scientific rigor and clarity of my work on the acupuncture-mediated modulation of gastrointestinal metabolic pathways. The professionalism, efficiency, and dedication demonstrated throughout the submission and revision stages have been truly commendable. This experience has been invaluable to my academic growth. Thank you again for your unwavering support of innovative translational research. Sincerely,Tiancheng XuAssociate ProfessorNanjing University of Chinese Medicine " [Collapse]

Wang SY, Zhang MZ, Chen ZM, Li ZM, Xie CY, Yang GH, Xu B, Xu TC. Intestinal-related substances in obesity regulation: A comprehensive review. World J Gastrointest Pharmacol Ther 2025; 16(4): 111082

20175 items Read more >>

Article Quality Tracking-Peer-Review

"In recent years, knowledge of the diagnostic and therapeutic roles of stem cells in many digestive system diseases has increased ..." [Read more]

"In recent years, knowledge of the diagnostic and therapeutic roles of stem cells in many digestive system diseases has increased dramatically. Stem cells, with their inherent self-renewal and differentiation capabilities, can expand the therapeutic possibilities of modern gastroenterology across varied diagnostic and therapeutic fields. For example, as the authors of this review report, liver organoids derived from human pluripotent stem cells are used for diverse liver cancer remodeling and drug-sensitivity testing. Furthermore, mesenchymal stem cells/stromal cells are used in clinical/therapeutic studies for a large number of liver diseases. It is known that liver diseases (benign and malignant) result in high morbidity and mortality in all countries of the world. The financial burden on international health systems is becoming increasingly unsustainable in many countries, even in those that are highly developed economically. The implementation of stem cell-based diagnosis and treatment strategies for liver diseases is expected to become a reality in the near future, with visible consequences not only in the successful care of patients but also in improving healthcare economic parameters. " [Collapse]

Wang YX, Ren YN, Zhang SS, Sun S, Xu MY, Wei T, Zhang LS. Application of stem cells in the precise diagnosis and treatment of liver diseases. World J Gastroenterol 2025; 31(46): 114415

"1. This review presents a thorough and timely overview of stem cell-based strategies in the diagnosis, modeling and treatment of liver ..." [Read more]

"1. This review presents a thorough and timely overview of stem cell-based strategies in the diagnosis, modeling and treatment of liver diseases. The authors have gathered an impressive volume of literature and have covered a wide spectrum of topics that range from pluripotent stem cell differentiation to organoid systems and clinical applications. One of the most notable strengths of the manuscript is the inclusion of clinical trial information, which has been organized into clear and informative tables that greatly enhance the translational relevance of the work. Although the content is comprehensive and highly informative, the overall narrative would benefit from more concise expression because certain sections contain repeated explanations and overly detailed descriptions that affect readability. 2. References：The manuscript contains a rich and extensive reference list, which reflects careful and comprehensive literature collection. This is a clear advantage of the review and provides the reader with broad and current coverage of relevant studies. 3. Language：The manuscript generally uses appropriate scientific terminology and conveys complex concepts accurately. However, the writing occasionally becomes verbose and repetitive. Several paragraphs contain long and heavily structured sentences, repeated connective phrases and extensive lists of factors or markers. These patterns interrupt the natural flow of the text and make some sections difficult to read. A more concise presentation of key ideas and smoother transitions between paragraphs would help strengthen the clarity and coherence of the manuscript. Reducing repeated descriptions of differentiation procedures, signaling pathways and mesenchymal stem cell mechanisms would particularly improve the overall fluency. 4. Figures and tables：The figures and tables play a helpful role in supporting the manuscript. The tables summarizing differentiation methods and clinical trials are especially informative and make complex information more accessible to readers. Some figures contain a large amount of condensed information and many abbreviations, which may make them difficult to interpret at a glance. However, the authors have provided all the abbreviations right next to each table, which is very good. In addition, figure 2 that integrates the major mechanisms and introduction of stem cell-based liver organoids is exquisite visually but may require further editing conceptually. 5. Caveats or drawbacks： Although the review provides extensive information, it relies heavily on descriptive summaries and would benefit from deeper analytical discussion. Several important challenges are mentioned only briefly, such as heterogeneity among stem cell sources, safety considerations in clinical translation, variability of organoid systems and the limited outcomes of early clinical studies. A more thorough examination of these issues would give the review greater authority and balance. Overall, the manuscript offers a rich collection of information and valuable resources, especially through its comprehensive references and clinical trial summaries. The quality of the paper would be further improved by tightening the language, and reducing redundancy. I would like to comment a little bit more at the end of this ‘Track article quality’ section. The review appropriately highlights stem cell derived exosomes and extracellular vesicles, which is a valuable component of the manuscript. As far as current knowledge suggests, multiple clinical trials involving exosomes or other extracellular vesicle based therapeutics are actively underway. These vesicle based preparations may offer functional advantages comparable to their parental stem cells, while potentially avoiding several practical and safety related challenges associated with cell based therapies, including difficulties in storage, risks of uncontrolled proliferation, and concerns related to tumorigenesis. Given these advantages, a more extensive discussion of exosomes, extracellular vesicles, and their clinical development would further strengthen the manuscript. This topic may be an excellent focus for the authors to expand upon in their future work. Considering the comprehensive scope and overall quality of this review, I would also recommend it for recognition or award within the journal. " [Collapse]

Wang YX, Ren YN, Zhang SS, Sun S, Xu MY, Wei T, Zhang LS. Application of stem cells in the precise diagnosis and treatment of liver diseases. World J Gastroenterol 2025; 31(46): 114415

"The authors express concern about the lack of detailed analysis of the depth of analysis, i.e., tumor miss rates, machine learning ..." [Read more]

"The authors express concern about the lack of detailed analysis of the depth of analysis, i.e., tumor miss rates, machine learning model complexity, and dataset quality. They also discuss future directions for the potential of AI in endoscopy training to facilitate skill development and improve the overall proficiency of endoscopists, a crucial area for the future adoption of AI in clinical practice. For AI endoscopy to further develop, we need to work on updating image data and deep learning." [Collapse]

Fogas CR, Balassone V. Artificial intelligence in gastrointestinal endoscopy: Focus on analytical depth and endoscopist training. Artif Intell Gastrointest Endosc 2025; 6(4): 115140

"AI is an important milestone for future development in medicine and science. Nonetheless, there are many AI models and each model ..." [Read more]

"AI is an important milestone for future development in medicine and science. Nonetheless, there are many AI models and each model has its own learning objectives. Incorporation of multiple AI models and training machine/ learning can greatly enhance the accuracy and readiness of using it to help in hepatopathy. Also, there are many hepatopathy and a systematic way to categories them will be a challenging act." [Collapse]

Sun JR, Sun XN, Lu BJ, Deng BC. Artificial intelligence in hepatopathy diagnosis and treatment: Big data analytics, deep learning, and clinical prediction models. World J Gastroenterol 2025; 31(45): 111176

"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..." [Read more]

"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied." [Collapse]

Wu PE, Chen PJ, Su WC, Chang TK, Chen YC. Perforated sigmoid colon diverticulitis initially presenting with pneumoperitoneum, pneumoretroperitoneum, and pneumomediastinum: A case report. World J Clin Cases 2025; 13(34): 112593

"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..." [Read more]

Deng X, Lv LY, Jiang SX, Huang JX, Chen XY, Zhang MF, Qi J, Yang M. Low-grade appendiceal mucinous neoplasm: A case report. World J Clin Cases 2025; 13(34): 111668

"With all due respect, this case shouldn't have been accepted for publication. I lacks complete originality and shows lots of ..." [Read more]

"With all due respect, this case shouldn't have been accepted for publication. I lacks complete originality and shows lots of contradictions. That is, the title contradicts the case itself. Initially presenting with Pneumoperitoneum and the cases report indicates that the patient had "three (3) days" with lower abdominal pain. Irregardless of that, whatever clinical presentation, this case shows nothing new that has previously been reported. In conclusion this case report lacks complete originality." [Collapse]

"First of all, congratulations on the publication of your paper. I have read it carefully, and I found it to be extremely well written, ..." [Read more]

"First of all, congratulations on the publication of your paper. I have read it carefully, and I found it to be extremely well written, highly educational, and truly informative for readers. For these reasons, I would like to award this paper the first prize. I hope you will continue to produce such valuable work in the future. Thank you very much." [Collapse]

Usuda D, Furukawa D, Imaizumi R, Ono R, Kaneoka Y, Nakajima E, Kato M, Sugawara Y, Shimizu R, Inami T, Kawai K, Matsubara S, Tanaka R, Suzuki M, Shimozawa S, Hotchi Y, Osugi I, Katou R, Ito S, Mishima K, Kondo A, Mizuno K, Takami H, Komatsu T, Nomura T, Sugita M. Recurrence of acyclovir-resistant herpes encephalitis in an immunocompromised patient: A case report. World J Clin Cases 2025; 13(34): 111438

"At the Baveno VII consensus workshop has defined the concept of recompensation of decompensated liver cirrhosis. It implies that after ..." [Read more]

"At the Baveno VII consensus workshop has defined the concept of recompensation of decompensated liver cirrhosis. It implies that after elimination of the etiological factor, there is at least a partial regression of structural and functional disorders in the liver, reduction of portal pressure with a positive effect on portal hypertension related complications. Many studies have shown the efficacy of direct acting antivirals (DAAs) in achieving recompensation of HCV-related decompensated liver cirrhosis. The authors confirmed these data in Egyptian patients." [Collapse]

Abdel Hafez RS, Semeya AA, Elgamal R, Othman AA. Direct-acting antiviral therapy reduces variceal rebleeding and improves liver function in hepatitis C virus-related cirrhosis: A multicenter retrospective cohort study. World J Hepatol 2025; 17(11): 110638

"This is a comprehensive and well-structured review that effectively synthesizes the complex landscape of MASLD in Egypt. The authors ..." [Read more]

"This is a comprehensive and well-structured review that effectively synthesizes the complex landscape of MASLD in Egypt. The authors have articulated the convergence of risk factors, diagnostic challenges, and management gaps, positioning MASLD as a critical public health priority. The article's strength lies in its contextualization of the problem within Egypt's unique epidemiological and socioeconomic backdrop, particularly the interplay with the legacy of HCV and nutritional transitions. The inclusion of figures illustrating the multifactorial risks enhances the manuscript's clarity and impact. There are several inherent challenges remain unresolved. The review points out that studies evaluating the prevalence of MASLD in Egypt are scarce and often include small numbers, and the prevalence and impact of key genetic variants (e.g., PNPLA3, TM6SF2) in the Egyptian population remain underexplored. The natural history and progression rates of MASLD specifically within the Egyptian population are not well-defined due to the absence of longitudinal cohort studies. The authors have already laid out a roadmap for future research. They intend to advocate for and potentially lead large-scale, population-based epidemiological studies. The appropriate methodology like a stratified cluster sampling design, and the non-invasive diagnostics like FibroScan, could ensure the accuracy to assess the prevalence and fibrosis stages. The review by Abdelhamed et al. is a powerful call to action, raising interest in non-communicable disease like MASLD in Egypt, and providing an evidence-based argument for a public health-oriented approach to a complex disease. " [Collapse]

Abdelhamed W, Amin M, Waked I, El-Kassas M. Metabolic dysfunction-associated steatotic liver disease in Egypt: Epidemiology, risk factors and management challenges. World J Gastroenterol 2025; 31(45): 111643

"This manuscript showed the cellular mechanisms of pentadecanoic acid as an odd-number fatty acid. The presented figures are interesting ..." [Read more]

"This manuscript showed the cellular mechanisms of pentadecanoic acid as an odd-number fatty acid. The presented figures are interesting and include valuable information, especially Figure 2, which shows the relation between pentadecanoic acid and cell signaling. In this figure, Mek/ERk and JAK/STAT pathways were shown as the pathways in which pentadecanoic acid was engaged." [Collapse]

Mercola J. Molecular and cellular mechanisms of pentadecanoic acid. World J Biol Chem 2025; 16(4): 111258

"This manuscript showed biomarkers for Gestational diabetes mellitus, which is an important metabolic disorder in pregnancy. The authors ..." [Read more]

"This manuscript showed biomarkers for Gestational diabetes mellitus, which is an important metabolic disorder in pregnancy. The authors have shown the biochemical parameters of the healthy and diabetic participants. This is a good point. The authors also showed a good agarose electrophoresis of PCR products. In addition, the gene expression of gene variants was studied and proved as biomarkers of Gestational diabetes mellitus. " [Collapse]

Shamsad A, Gautam T, Singh R, Banerjee M. CD36 fatty-acid-transporter gene variants-CD36 G/A (rs1761667) and CD36 C/T (rs75326924) as biomarkers for risk-prediction in gestational diabetes mellitus. World J Biol Chem 2025; 16(4): 111104

"Laparoscopic hepatectomy is a minimally invasive surgical procedure to remove part of the liver in cases of benign and/or malignant ..." [Read more]

"Laparoscopic hepatectomy is a minimally invasive surgical procedure to remove part of the liver in cases of benign and/or malignant tumors of the organ. Patients benefit from all the advantages of laparoscopic surgery, such as faster recovery, minimal pain, and smaller surgical wounds, compared to open surgery. Lei ZL et al. in their study entitled “Comparison of the efficacy of laparoscopic hepatectomy and radiofrequency ablation for small hepatocellular carcinoma: A retrospective study. World J Gastroenterol 2025; 31(45): 111540 demonstrated that, in patients with small hepatocellular carcinoma, laparoscopic hepatectomy significantly prolongs survival compared with tumor destruction. The findings suggest that laparoscopic hepatectomy should be preferred in these patients, provided liver function is adequate. Nevertheless, radiofrequency tumor destruction remains a valuable weapon in our pharmaceutical arsenal, especially in patients at high surgical risk. It is understandable, however, that these surgical procedures must be performed in specialized centers by surgeons with extensive experience in laparoscopic surgery, particularly in liver surgery." [Collapse]

Lei ZL, Tan ZL, Luo YH, Yang M, Wang JL, Qin Z, Liu YY. Comparison of the efficacy of laparoscopic hepatectomy and radiofrequency ablation for small hepatocellular carcinoma: A retrospective study. World J Gastroenterol 2025; 31(45): 111540

"This mechanism showed an understanding of mechanisms. As a review article, it includes important information about obesity. Figures ..." [Read more]

"This mechanism showed an understanding of mechanisms. As a review article, it includes important information about obesity. Figures 1 and 2 were well designed. The therapeutic strategies in Table 1 also included important information. The authors are urged to perform research work on the subject area of this manuscript, especially the concept of the therapeutic strategy. " [Collapse]

Chen KR, Chen ZY, Liu FY, Xie CY, Hu J, Wang SY, Xu B, Xu TC. Macrophage-mediated metabolic dysregulation in the pancreas: Insights from obesity. World J Biol Chem 2025; 16(4): 109509

"This study analyzes RSPO3 rearrangements in advanced colorectal cancer (aCRC) and their clinical implications. Among 73 patients with ..." [Read more]

"This study analyzes RSPO3 rearrangements in advanced colorectal cancer (aCRC) and their clinical implications. Among 73 patients with stage pT4a‑b tumors, RSPO3 fusions were detected in 8% of cases, predominantly in right‑sided or transverse colon cancers. These rearrangements were associated with smaller tumor size, normal carcinoembryonic antigen levels, microsatellite stability, and significantly poorer overall survival. The authors also confirmed through in silico analyses that elevated RSPO3 expression correlates with worse recurrence‑free and overall survival in independent CRC cohorts. Strengths of the work include comprehensive next‑generation sequencing of 50 cancer‑related genes, detailed clonal evolution analysis, and integration of clinical, pathological, and molecular data. Overall, the study highlights RSPO3 fusions as a potential prognostic biomarker and therapeutic target in advanced colorectal cancer." [Collapse]

Tur R, Abad M, Filipovich E, Rivas MB, Rodriguez M, Montero JC, Sayagués JM. RSPO3 rearrangements in advanced colorectal cancer patients and their relationship with disease characteristics. World J Gastrointest Oncol 2025; 17(11): 112838

"This retrospective study develops and validates a novel nomogram model to predict survival outcomes in advanced HER‑2 negative gastric ..." [Read more]

"This retrospective study develops and validates a novel nomogram model to predict survival outcomes in advanced HER‑2 negative gastric cancer patients treated with immunochemotherapy. Using data from 200 patients who received sintilimab plus chemotherapy, the authors identified PD‑L1 expression, microsatellite status, TNM stage, tumor differentiation, neutrophil‑to‑lymphocyte ratio, and the C‑reactive protein–albumin–lymphocyte (CALLY) index as independent prognostic factors. The resulting models demonstrated strong discrimination (C‑index 0.78–0.82) and calibration, with high accuracy for progression‑free and overall survival across multiple time points. Strengths of the work include integration of molecular, clinical, and inflammatory markers into a single predictive tool, rigorous statistical validation, and clear demonstration of clinical applicability. Overall, the study provides a robust framework for individualized risk assessment and treatment planning in HER‑2 negative advanced gastric cancer." [Collapse]

Yao ZY, Bao G, Li GC, Hao QL, Ma LJ, Rao YX, Xu K, Ma X, Han ZX. Survival prognosis in advanced HER-2 negative gastric cancer treated with immunochemotherapy: A novel model. World J Gastrointest Oncol 2025; 17(11): 112981

"This meta‑analysis evaluates the efficacy of neoadjuvant immunotherapy combined with radiotherapy and chemotherapy in locally advanced ..." [Read more]

"This meta‑analysis evaluates the efficacy of neoadjuvant immunotherapy combined with radiotherapy and chemotherapy in locally advanced rectal cancer (LARC). Across 15 studies involving 796 patients, the addition of immunotherapy significantly improved major pathological response, pathological complete response, and clinical complete response, particularly in patients with proficient mismatch repair (pMMR) and microsatellite stability. Rates of R0 resection and sphincter‑preserving surgery were also higher, while adverse events such as hematologic toxicity and liver dysfunction remained within acceptable limits. Strengths of the study include comprehensive literature retrieval, rigorous subgroup and sensitivity analyses, and clear reporting of heterogeneity and publication bias. Overall, the findings suggest that integrating immunotherapy into neoadjuvant chemoradiotherapy regimens enhances remission and organ preservation without substantially increasing complications, supporting its consideration as a first‑line strategy for LARC." [Collapse]

Yan WX, Yuan HQ, Xiong ZY, Qin LJ, Wu J, He J, Mu J, Li J, Li N. Meta-analysis of the efficacy of neoadjuvant immunotherapy combined with radiotherapy and chemotherapy for locally advanced rectal cancer. World J Gastrointest Oncol 2025; 17(11): 113048

"This study investigates folate receptor–positive circulating tumor cells (FR+ CTCs) as potential biomarkers for hepatocellular ..." [Read more]

"This study investigates folate receptor–positive circulating tumor cells (FR+ CTCs) as potential biomarkers for hepatocellular carcinoma (HCC). In a retrospective cohort of 128 patients, FR+ CTC counts demonstrated superior diagnostic accuracy compared to alpha‑fetoprotein (AFP), with sensitivity of 90% and specificity of 77%. Elevated FR+ CTC levels correlated with adverse pathological features such as larger tumor size, multiple lesions, macrovascular invasion, and extrahepatic metastasis. Importantly, higher baseline FR+ CTC counts predicted shorter disease‑free survival after hepatectomy, with a cutoff of 12.9 FU/3 mL distinguishing high‑risk patients. Strengths of the work include rigorous methodology using ligand‑target PCR, clear statistical validation with ROC and Cox regression analyses, and demonstration that FR+ CTCs may serve both diagnostic and prognostic roles independent of AFP. These findings provide promising evidence that FR+ CTC quantification could enhance patient stratification, guide treatment evaluation, and improve recurrence prediction in HCC." [Collapse]

Zhang ZY, Zhou M, Liu JJ, Zhang W. Folate receptor-positive circulating tumor cells might function as potential biomarkers for hepatocellular carcinoma. World J Gastrointest Oncol 2025; 17(11): 113431

"This article presents two rare case reports of gastrointestinal stromal tumors (GISTs) driven by novel FGFR2 fusions, expanding the ..." [Read more]

"This article presents two rare case reports of gastrointestinal stromal tumors (GISTs) driven by novel FGFR2 fusions, expanding the molecular spectrum beyond the well‑known KIT and PDGFRA mutations. Both patients underwent successful surgical resection followed by adjuvant imatinib therapy, achieving sustained remission over more than two years. The study is well executed in several respects: it highlights the importance of comprehensive genomic profiling with next‑generation sequencing to uncover actionable mutations, demonstrates that even non‑canonical alterations may respond to standard tyrosine kinase inhibitors, and underscores the potential of FGFR‑targeted therapies for imatinib‑resistant or advanced disease. By carefully documenting clinical, pathological, and molecular features, the authors provide valuable preliminary evidence that FGFR2 fusions may define a distinct, therapeutically relevant GIST subtype." [Collapse]

Hong YY, Shou CH, Yang WL, Wang XD, Zhang Q, Liu XS, Yu JR. FGFR2 fusions as novel oncogenic drivers in gastrointestinal stromal tumors: Two case reports and review of literature. World J Gastrointest Oncol 2025; 17(11): 113262

"I read with interest of this article. In spite of there are many similar studies in literature, the findings of this study is still ..." [Read more]

"I read with interest of this article. In spite of there are many similar studies in literature, the findings of this study is still informative. Shear wave elastography (SWE) is a non-invasive ultrasound (US) technique that can quantify tissue stiffness, which can used for assistance of diagnosing focal and diffusive diseases. Establishing reference values in normal tissues or organs in healthy individuals is crucial, since abnormal stiffness is associated with clinically relevant conditions such as tumors, liver fibrosis, and pancreatic disease. In the literature, normal values of stiffness for liver, spleen, and pancreas in healthy individuals are various, and they have not been well established. In this study, the investigators measured the stiffness of the liver, spleen, and pancreas in 50 healthy subjects with p-QElaXto and 2D-QElaXto on Esaote MyLab 9 ultrasound system, compared with 2D-SWE on the SuperSonic Imagine Aixplorer (SSI). Values of measurements of stiffness ranges were analyzed for relationship with clinical and technical factors, and inter-operator variability across the different SWE modalities were studied. The results demonstrated that the liver and spleen stiffness assessment was feasible in > 98% of patients, while pancreas stiffness was measurable in 84%-88% depending on the SWE technique. Mean liver stiffness ranged between 3.9-4.7 kPa across techniques, spleen stiffness ranged from 19.4-23.0 kPa, and pancreas stiffness from 5.2-7.6 kPa. Inter-operator agreement was excellent for liver and good to moderate for spleen and pancreas. Bland-Altman analysis confirmed good correlation but also systematic differences among devices, especially in pancreas measurements. The investigators concluded that the values of stiffness of the liver and spleen matched existing guidelines, and pancreas SWE showed more variability and reduced reproducibility. Stiffness measurements of the pancreatic using shear wave elastography is less reliable than that for liver and spleen. There were some potential limitations of this study, as had been addressed in the article, especially the relatively small sample size compromises the soundness and robust of the results. " [Collapse]

Viceconti N, Paratore M, Del Zompo F, Zocco MA, Ainora ME, Esposto G, Gasbarrini A, Pompili M, Riccardi L, Garcovich M. Shear wave elastography in healthy patients: Pancreatic stiffness is less reliable than liver and spleen measurements. World J Radiol 2025; 17(11): 111651

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