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Articles In Press
1
Chamchoum E, Katrib N, Nassif N, Ratel Y, Rida MA. Glucagon like peptide and its receptor agonists in the treatment of rheumatic diseases. World J Exp Med 2025; In press
2025-07-10 | Browse: 6 | Download: 0
2
Kanellou V, Kaliarntas K, Dounavi DM, Patsaki I, Kalpaxis D, Kourek C, Dimopoulos S. Early mobilization in patients on venoarterial extracorporeal membrane oxygenation: A scoping review. World J Cardiol 2025; In press
2025-07-10 | Browse: 2 | Download: 0
3
Zuo XY, Liu HF. Biparametric magnetic resonance imaging-based radiomic and deep learning models for predicting Ki-67 risk stratification in hepatocellular carcinoma. World J Hepatol 2025; In press
2025-07-10 | Browse: 1 | Download: 0
4
Xie RX, Xing YX, Sun NZ. Advancing bone regeneration: Clinical implications of synthetic biomaterials and fibrin derivatives. World J Orthop 2025; In press
2025-07-10 | Browse: 1 | Download: 0
5
Liu QZ, Zeng L, Sun NZ. Radiomics for preoperative pancreatic ductal adenocarcinoma risk stratification: Cross-population validation, multidimensional integration, challenges, and future directions. World J Radiol 2025; In press
2025-07-10 | Browse: 1 | Download: 0
6
ShamsEldeen AM, Hosny SA, Maghib KA, Ashour HA. Current perspectives on regenerative potential of mesenchymal stem cells in alleviating cardiac injuries: Molecular pathways and therapeutic enhancement. World J Stem Cells 2025; In press
2025-07-10 | Browse: 3 | Download: 0
7
Choudhery MS, Arif T, Mahmood R. Applications of artificial intelligence in stem cell therapy. World J Stem Cells 2025; In press
2025-07-10 | Browse: 0 | Download: 0
8
Nampoolsuksan C, Parakonthun T. Enhanced recovery after surgery protocols in gastrectomy with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for gastric cancer. World J Clin Oncol 2025; In press
2025-07-10 | Browse: 2 | Download: 0
9
Lew LC, Mat Ludin AF, Abdul Manaf Z, Mohd Tohit N, Shahar S. Mapping evidence and identifying risks: A systematic scoping review of meal replacements in type 2 diabetes. World J Diabetes 2025; In press
2025-07-10 | Browse: 3 | Download: 0
10
Luo TT, Dong MY, Zhao S, Zhai XZ. Effects of the support system combined with Chinese medicine on postoperative gastrointestinal recovery in patients with liver cancer. World J Gastrointest Oncol 2025; In press
2025-07-10 | Browse: 0 | Download: 0
11
Xiao S, Xu XZ, Liao M, Song DD, Tang JF, Zhou CF. Potential risks of histone deacetylase inhibitors in cancer therapeutics and feasible combination therapeutic strategies. World J Clin Oncol 2025; In press
2025-07-10 | Browse: 8 | Download: 0
12
Ma YB, Wang ZJ. Current advances in neuroendocrine neoplasms of the colon and rectum. World J Clin Oncol 2025; In press
2025-07-10 | Browse: 12 | Download: 0
13
Zheng J, Wang J, Zhou YN, Yu TT, Ye WK. Preoperative interleukin-17a as a predictor of acute pancreatitis after pancreaticoduodenectomy. World J Gastrointest Surg 2025; In press
2025-07-10 | Browse: 12 | Download: 0
14
Shan GD, Ning LG, Zhang FM, Du HJ, Chen WG, Wang JJ, Li AQ, Xu GQ, Chen HT. Clinicopathological and endoscopic ultrasonography characteristics of esophageal bronchogenic cysts: A single-center study. World J Gastrointest Surg 2025; In press
2025-07-10 | Browse: 13 | Download: 0
15
Li ZY, Xie C, Cai HQ. Overview of Yttrium-90 radioembolization for advanced hepatocellular carcinoma: Current status and future perspectives. World J Clin Oncol 2025; In press
2025-07-10 | Browse: 10 | Download: 0
16
Nguyen JT, Anand M. Avacopan in the treatment of relapsing polychondritis with myeloperoxidase-antineutrophil cytoplasmic antibody associated vasculitis: A case report. World J Nephrol 2025; In press
2025-07-10 | Browse: 13 | Download: 0
17
Özcan P, Düzgün Ö. Comparison of complication rates after early and late closure of loop ileostomies: A retrospective cohort study. World J Gastrointest Surg 2025; In press
2025-07-10 | Browse: 13 | Download: 0
18
Harris E, Rhudy C, Roy L, Cloud A, Leyson CD. Sex differences in severity, outcomes, and healthcare utilization in alcohol-associated hepatitis. World J Hepatol 2025; In press
2025-07-09 | Browse: 17 | Download: 0
19
Shahid M, Hilal K, Khan M, Ejaz ZH, Altaf S, Islam S, Khandwala K. Imaging insights into pediatric liver masses: A comprehensive minireview for hepatology practice. World J Hepatol 2025; In press
2025-07-09 | Browse: 15 | Download: 0
20
Elkhattib I, Raafat KW, Elsayed B, Elnaggar M. Chronic hepatitis C and the risk for atherosclerotic and cardiomyopathic heart disease. World J Hepatol 2025; In press
2025-07-09 | Browse: 14 | Download: 0
687 items  Read more >>
Author Reviews
1
""It is an honor to continue publishing in your prestigious journal as part of a long-standing effort that began several months ago ..."  [Read more]
""It is an honor to continue publishing in your prestigious journal as part of a long-standing effort that began several months ago with an invited minireview originally submitted to the World Journal of Gastroenterology, which was later redirected here after a thorough evaluation. We are very pleased with this outcome, especially as I am a member of the editorial board. I sincerely appreciate the excellent work of the reviewers and the slightly extended editing process, which reflects the meticulous and scrupulous standards of your journal and undoubtedly contributes to its high editorial quality. "  [Collapse]
Delgado Galan M, Quintanilla Lazaro E, Rabago Torre LR. Postcolonoscopy colorectal cancer: What we need to know in the age of screening and magnifying endoscopy techniques. World J Gastrointest Endosc 2025; 17(7): 107430
2
"The submission, review, and publication processes for this manuscript were remarkably efficient and well-organized. The online ..."  [Read more]
"The submission, review, and publication processes for this manuscript were remarkably efficient and well-organized. The online submission system was user-friendly, allowing for seamless uploading of all required files and information. The editors provided prompt and clear communication throughout the process. The peer reviewers delivered thorough and constructive feedback in a timely manner, which greatly improved the quality of the manuscript. Revisions were handled smoothly, with clear instructions provided. "  [Collapse]
Gadour E, Miutescu B, Okasha HH, Albeshir M, Alamri T, Ghoneem E, Burciu C, Popa A, Koppandi O, AlQahtani MS. Evolving role of endoscopic ultrasound in biliary stricture management: A meta-analysis and systematic review. World J Gastrointest Endosc 2025; 17(7): 108541
3
"We sincerely appreciate the efficient review process and the valuable feedback provided by the reviewers. The editorial team was ..."  [Read more]
"We sincerely appreciate the efficient review process and the valuable feedback provided by the reviewers. The editorial team was supportive and communicative throughout. Although there was a slight delay in processing after the APC payment, which caused some concern, the overall experience was positive, and it was a pleasure to publish our case report in this journal. "  [Collapse]
Shin SY, Yeon HJ, Lee SO, Lee JR, Leem G, Han SJ. Fatal air embolism during intestinal endoscopy in Kasai portoenterostomy for biliary atresia: A case report. World J Gastrointest Endosc 2025; 17(7): 105773
4
"Thank you to editor Lili and the editorial team for their prompt and helpful responses throughout the submission process, which enabled ..."  [Read more]
"Thank you to editor Lili and the editorial team for their prompt and helpful responses throughout the submission process, which enabled the smooth publication of this innovative gastric preparation study. In our research, we found that drinking 550 mL of carbonated soft drink before MCE led to better and more sustained gastric filling for at least 10 minutes, compared to drinking 1000 mL of pure water, and may also promote gastric emptying. This provides a preliminary clinical evaluation of a novel gastric preparation regimen for MCE, demonstrating that carbonated soft drink offers superior and longer-lasting gastric filling than pure water. "  [Collapse]
Zhu JH, Liu X, Zhou W, Xu XN, Sheng WD, Han YL, Qiu XO, Liu YW, Qian YY, Liao Z, Li ZS. Carbonated soft drink for gastric preparation for magnetically controlled capsule endoscopy: An open-label randomized controlled trial. World J Gastroenterol 2025; 31(24): 105823
5
"Our experience with the World Journal of Clinical Cases' evaluation and publication process has been exceptionally positive. We would ..."  [Read more]
"Our experience with the World Journal of Clinical Cases' evaluation and publication process has been exceptionally positive. We would like to express our gratitude to the editorial team for their rapid communication and the remarkably smooth progression of our submission. For future enhancements, we recommend simplifying the user interface to improve user-friendliness. "  [Collapse]
Cicek E, Karatepe YK, Kantarcı TR, Sahin TT. Demanding sleeve gastrectomy procedure in a patient with severe intraabdominal adhesions: A case report and review of the literature. World J Clin Cases 2025; 12(23): 104807
6
"Publishing with this journal was a highly positive experience. The peer review process was thorough yet constructive, offering ..."  [Read more]
"Publishing with this journal was a highly positive experience. The peer review process was thorough yet constructive, offering insightful feedback that strengthened our manuscript. Communication with the editorial team was prompt and professional throughout. The submission platform was user-friendly, and timelines for review and publication were clearly communicated and adhered to. We felt supported and valued as contributors, and we appreciated the journal's commitment to scientific rigor and visibility. Overall, a smooth and rewarding experience. "  [Collapse]
Ansari N, Twohig P. Silent sabotage: How hepatitis B virus-miR-3 disarms innate immunity through cGAS-STING suppression. World J Hepatol 2025; 17(6): 106493
7
"Thank you very much to the editors and reviewers of your journal for their recognition and support of our manuscript. We are truly ..."  [Read more]
"Thank you very much to the editors and reviewers of your journal for their recognition and support of our manuscript. We are truly honored to have our case report published in your esteemed journal. This successful publication would not have been possible without your efficient and professional workflow and the hard work of everyone involved. Once again, we express our deepest gratitude to all of you. "  [Collapse]
Ma TT, Lyu HR. Post-endoscopic retrograde appendicitis therapy stent impaction leading to exacerbation of appendicitis: A case report. World J Clin Cases 2025; 13(25): 106587
8
"This journal maintains high academic standards with a rigorous peer-review process, ensuring quality publications. It has a strong ..."  [Read more]
"This journal maintains high academic standards with a rigorous peer-review process, ensuring quality publications. It has a strong reputation in its field, offering timely dissemination of research. The editorial team is professional and responsive. With a solid impact factor and global reach, it provides excellent visibility for authors. A reliable choice for impactful scholarly work. "  [Collapse]
Xiao Y, Ren BC, Zhang T, Peng D, Min J. Factors influencing postoperative complications in patients with gastric cancer: A retrospective study. World J Gastrointest Surg 2025; 17(5): 101047
9
"The online submission system runs smoothly and easy to master for authours who use for the first time. The peer review report is ..."  [Read more]
"The online submission system runs smoothly and easy to master for authours who use for the first time. The peer review report is helpful and objective. The anonymous peer review process is of high efficiency. The period of publication is rather short. The editors of the journal are very friendly and earnest. "  [Collapse]
Hou XL, Chen J, Cui MH, Yang GB. Extensive idiopathic mesenteric phlebosclerosis presenting as intestinal pseudo-obstruction: A case report. World J Clin Cases 2025; 13(25): 105028
10
"It would be helpful to have a simpler way to submit files. Adding an easy drag-and-drop option can save time and reduce confusion. ..."  [Read more]
"It would be helpful to have a simpler way to submit files. Adding an easy drag-and-drop option can save time and reduce confusion. Clear steps on how to upload files and a message to confirm the file was sent successfully would make the process smoother and less stressful for everyone, especially for those who are not very tech-savvy. "  [Collapse]
Harna B, Arya S. Tramadol overdose in total knee arthroplasty: A case report. World J Clin Cases 2025; 13(25): 104742
11
"We are very satisfied with the editorial and peer review process. The editors and reviewers have provided no additional comments or ..."  [Read more]
"We are very satisfied with the editorial and peer review process. The editors and reviewers have provided no additional comments or concerns regarding our manuscript. We appreciate the thorough and efficient review process, and we are pleased that our work meets the publication standards. We look forward to the next steps in the publication process. "  [Collapse]
Sun Q, Wu JC, Chen X, Li DH, Li BR, Xiao NJ, Wang XY, Tu XZ, Ning SB, Sun T. Efficacy and safety of sirolimus in the treatment of gastrointestinal angiodysplasias. World J Gastroenterol 2025; 31(25): 105677
12
"Our recent experience with submitting and publishing our manuscript, titled "Nursing care of a patient with negative symptoms of ..."  [Read more]
"Our recent experience with submitting and publishing our manuscript, titled "Nursing care of a patient with negative symptoms of schizophrenia who underwent tracheotomy: A case report," in the World Journal of Clinical Cases was exceedingly positive and surpassed our expectations. We extend our profound gratitude for the rigorous and constructive nature of the peer review process. The timely and highly perceptive feedback provided by the anonymous reviewers was greatly appreciated. Their comments, which were both critical and demonstrated a sophisticated understanding of our research domain, guided us in making significant improvements to the quality of our manuscript, enhancing the precision of our key information, and improving the clarity and overall impact of our findings. The editorial handling by the editorial team was also exemplary. Communication was consistently prompt, transparent, and highly professional at every stage, from initial submission decisions to post-acceptance production. Their efficiency ensured a smooth progression of our manuscript through all phases. Finally, the post-acceptance production team was swift and meticulous in preparing our article for publication. The entire process, from submission to online appearance, was surprisingly quick without compromising on quality checks. We are incredibly grateful for the opportunity to publish our work in the World Journal of Clinical Cases. We wholeheartedly recommend this journal to fellow researchers in Psychiatric nursing who are seeking a publishing venue that combines a streamlined submission process with an outstandingly supportive and rigorous peer-review and editorial experience. It truly contributes to advancing high-quality research within the field. "  [Collapse]
Li JY, Liu XE, Li W, Wang LN. Nursing care of a patient with negative symptoms of schizophrenia who underwent tracheotomy: A case report. World J Clin Cases 2025; 13(25): 108124
13
"I was very satisfied with the overall editorial and publication process. The peer review was fair, constructive, and timely. The ..."  [Read more]
"I was very satisfied with the overall editorial and publication process. The peer review was fair, constructive, and timely. The editorial office maintained clear communication throughout, and the revisions were handled efficiently. I did not encounter any particular difficulties, and I appreciate the professionalism and responsiveness of the editorial team. "  [Collapse]
Lee AY, Lim SG, Cho JY, Kim S, Lee KM, Shin SJ, Noh CK, Lee GH, Hur H, Han SU, Son SY, Song JH. Comparison of treatment strategies for submucosal tumors originating from the muscularis propria at esophagogastric junction or cardia. World J Gastroenterol 2025; 31(23): 106261
14
"The peer review process and publication process were compact and soon. In general, we were satisfied with the whole process of the ..."  [Read more]
"The peer review process and publication process were compact and soon. In general, we were satisfied with the whole process of the course of submission. In addition, we would like to suggest our colleagues to submit their works to the Journal according to the efficient managements from the editorial office. "  [Collapse]
Chang YC, Liu WN, Lin F, Lin GM. Mood alteration and heart rate variability in patients with cancer on treatment. World J Cardiol 2025; 17(6): 107114
15
"We feel extremely honored and delighted to have our article published in the World Journal of Gastroenterology. The entire submission ..."  [Read more]
"We feel extremely honored and delighted to have our article published in the World Journal of Gastroenterology. The entire submission process was smooth and efficient, and the editorial team was incredibly supportive and professional. Their constructive feedback significantly improved our manuscript. We truly appreciate the positive experience and the platform this journal provides for disseminating important research. "  [Collapse]
Huang SS, Chen W, Vaishnani DK, Huang LJ, Li JZ, Huang SR, Li YZ, Xie QP. Leucine-rich repeat-containing protein 19 suppresses colorectal cancer by targeting cyclin-dependent kinase 6/E2F1 and remodeling the immune microenvironment. World J Gastroenterol 2025; 31(25): 107893
16
"We sincerely thank the editorial board and reviewers of the World Journal of Gastroenterology for their constructive comments and ..."  [Read more]
"We sincerely thank the editorial board and reviewers of the World Journal of Gastroenterology for their constructive comments and professional handling of our manuscript. The review process was thorough, transparent, and timely, contributing to the refinement and clarity of our work. We are pleased that our study has been accepted for publication in this well-regarded journal. "  [Collapse]
Gajovic NM, Jovanovic IP, Jocic MV, Stojanovic B, Corovic IF, Todorovic N, Simovic Markovic BJ, Amedei A. Exploring the impact of galectins on liver cancer: From immunopathogenesis to potential targets. World J Gastroenterol 2025; 31(25): 107260
17
"Thank you for publishing our work. We are grateful for the opportunity to contribute to the scientific community through your esteemed ..."  [Read more]
"Thank you for publishing our work. We are grateful for the opportunity to contribute to the scientific community through your esteemed journal. The publication process was smooth and professional, and we appreciate the editorial team's guidance. We hope our findings will spark further research and dialogue, and we look forward to future collaborations with your journal. "  [Collapse]
Basit A, Noor S, Ahmad SA, Noor N, Maryam R, Basil AM. Otitis media with effusion and hearing outcomes - Myringotomy vs myringotomy and tympanostomy: A comparative study. World J Otorhinolaryngol 2025; 12(1): 109355
18
"The entire process took too long from submission to publishing. In particular, it took too long from the submission of the revised ..."  [Read more]
"The entire process took too long from submission to publishing. In particular, it took too long from the submission of the revised paper (according to peer review) and the final publishing. We are satisfied with overall quality of the journal and the edited paper, but it’s not the first time that after peer review you take several months to finally publish the accepted and revised paper. "  [Collapse]
Liguori A, Ainora ME, Di Gialleonardo L, Viceconti N, Petrucci L, Esposto G, Giustiniani MC, Mignini I, Borriello R, Galasso L, Paratore M, Garcovich M, Riccardi L, Pompili M, Grieco A, Gasbarrini A, Miele L, Zocco MA. Multiparametric ultrasound for non-invasive assessment of liver steatosis, fibrosis, and inflammation in metabolic dysfunction-associated steatotic liver disease. World J Gastroenterol 2025; 31(25): 105518
19
"We sincerely appreciate the professional and efficient editorial process of the World Journal of Gastroenterology. From initial ..."  [Read more]
"We sincerely appreciate the professional and efficient editorial process of the World Journal of Gastroenterology. From initial submission to final publication, the entire workflow was transparent, well-organized, and timely. The reviewers provided constructive and insightful comments that significantly improved the quality of our manuscript. The editorial team was responsive and meticulous in their guidance, and the language editing was of high standard. We are grateful for the opportunity to publish in this reputable journal and look forward to future collaborations. "  [Collapse]
Wang XP, Zhu JX, Liu C, Zhang HW, Sun GD, Zhai JM, Yang HJ, Liu DC. Deciphering lactate metabolism in colorectal cancer: Prognostic modeling, immune infiltration, and gene mutation insights. World J Gastroenterol 2025; 31(25): 107478
20
"Thank you so much for this opportunity to work with you. I am hopeful to continue this association with you in future. I would like ..."  [Read more]
"Thank you so much for this opportunity to work with you. I am hopeful to continue this association with you in future. I would like to express my gratitude to the entire staff for the wonderful work they are doing. Keep doing the good work. I would like to request to reduce the time after acceptance to online publication. "  [Collapse]
Parry AH, Rehaman B, Bhat SA, Wani AH, Jehangir M, Baba AA. Role of magnetic resonance defecography in the assessment of obstructed defecation syndrome. World J Radiol 2025; 17(6): 107205
18981 items  Read more >>
Article Quality Tracking-Peer-Review
1
"Authors: Zhao JL, Wang MY, Lv YZ, Zhou YJ.  Article title: Prognostic value of inflammatory markers in predicting recurrence-free ..."  [Read more]
"Authors: Zhao JL, Wang MY, Lv YZ, Zhou YJ.  Article title: Prognostic value of inflammatory markers in predicting recurrence-free survival in gastrointestinal stromal tumor patients: A nomogram-based approach.  Their study revealed significant correlations between preoperative inflammatory markers [systemic immune-inflammation index, neutrophil/lymphocyte ratio, platelet/lymphocyte ratio (PLR) and monocyte/Lymphocyte ratio (MLR)] and recurrence-free survival in gastrointestinal stromal tumor (GIST) patients. The MLR and PLR were identified as independent risk factors for GIST recurrence. Research has highlighted the prognostic relevance of inflammatory markers in various cancers. Nomograms have been utilized in predicting survival and recurrence in different cancers. Their study pioneered the construction of a nomogram based on inflammatory markers for assessing the recurrence risk prognosis in GIST patients. The nomogram demonstrated utility in predicting GIST patient recurrence risk, emphasizing the ongoing sensitivity of inflammatory markers in patients receiving postoperative targeted therapy. Although their study design accompanied with some limitations for any conclusions, their results were informative for journal readers."  [Collapse]
Zhao JL, Wang MY, Lv YZ, Zhou YJ. Prognostic value of inflammatory markers in predicting recurrence-free survival in gastrointestinal stromal tumor patients: A nomogram-based approach. World J Gastrointest Oncol 2025; 17(2): 94956
2
"Authors: Li JD, He RQ, Dang YW, Huang ZG, Xiong DD, Zhang L, Du XF, Chen G.  Article title: Unveiling expression patterns, mechanisms, ..."  [Read more]
"Authors: Li JD, He RQ, Dang YW, Huang ZG, Xiong DD, Zhang L, Du XF, Chen G.  Article title: Unveiling expression patterns, mechanisms, and therapeutic opportunities of transmembrane protein 106C: From pan-cancers to hepatocellular carcinoma.  Herein, they conducted the study to investigate the expression implications, immune associations, and transcriptional regulatory mechanisms of transmembrane protein 106C (TMEM106C) across 34 cancer types, including liver hepatocellular carcinoma (LIHC). Their multicenter study represents the largest investigation to date of the expression pattern and biological functions of TMEM106C in LIHC. Of particular note, their study discovered the inhibitory effect of nitidine chloride on TMEM106C overexpression, which has not been reported previously. This paper is indicative for journal readers in this field."  [Collapse]
Li JD, He RQ, Dang YW, Huang ZG, Xiong DD, Zhang L, Du XF, Chen G. Unveiling expression patterns, mechanisms, and therapeutic opportunities of transmembrane protein 106C: From pan-cancers to hepatocellular carcinoma. World J Gastrointest Oncol 2025; 17(2): 92437
3
"Authors: Gemmell JS, Lucke-Wold B.  Article title: Traditional Chinese medicine and modern technology: Network pharmacology and omics ..."  [Read more]
"Authors: Gemmell JS, Lucke-Wold B.  Article title: Traditional Chinese medicine and modern technology: Network pharmacology and omics sequencing in gastric cancer. Gastric cancer (GC) is a heterogenous disease that incorporates the use of multiple metabolic pathways to contribute to tumorigenesis. Modern technology, which includes omics sequencing, has allowed for better characterization of these pathways and more targeted drug development by using natural components in food, nutraceuticals, to enhance treatment. However, current classification of GC as well as treatment does not address the complex nature of this disease. Omics technologies must be applied to characterize the subtypes of GC, which may lead to better application of nutraceuticals for both prevention and treatment. This letter is indicative."  [Collapse]
Gemmell JS, Lucke-Wold B. Traditional Chinese medicine and modern technology: Network pharmacology and omics sequencing in gastric cancer. World J Gastrointest Oncol 2025; 17(3): 102077
4
"Authors: Ma YY, Wang XH, Zeng JY, Chen JB, Niu LZ.  Article title: Irreversible electroporation combined with anti-programmed cell ..."  [Read more]
"Authors: Ma YY, Wang XH, Zeng JY, Chen JB, Niu LZ.  Article title: Irreversible electroporation combined with anti-programmed cell death protein 1 therapy promotes tumor antigen-specific CD8+ T cell response. Their study highlighted the synergistic effect of combining irreversible electroporation with anti-programmed cell death protein 1 therapy in the treatment of subcutaneous pancreatic cancer. The combination significantly enhanced T lymphocyte infiltration, elevated key cytokine levels, and promoted CD8+ T cell-mediated immune responses, resulting in a marked reduction in tumor volume. Their results suggest a promising avenue for improving immunotherapy strategies in pancreatic cancer through enhanced local tumor ablation methods. Their results are informative for journal readers in this field."  [Collapse]
Ma YY, Wang XH, Zeng JY, Chen JB, Niu LZ. Irreversible electroporation combined with anti-programmed cell death protein 1 therapy promotes tumor antigen-specific CD8+ T cell response. World J Gastrointest Oncol 2025; 17(3): 101991
5
"Authors: Sapkota A, Paudel R, Pandey S, Bhatt N.  Article title: Solid pseudopapillary neoplasm of the pancreas in an adolescent: ..."  [Read more]
"Authors: Sapkota A, Paudel R, Pandey S, Bhatt N.  Article title: Solid pseudopapillary neoplasm of the pancreas in an adolescent: A case report and review of the literature. Solid pseudopapillary neoplasm (SPN) of the pancreas is an uncommon pancreatic tumor that primarily impacts young women, especially those in their twenties and thirties. Their report highlights the case of a 15-year-old female patient who experienced a two-year history of abdominal pain and was diagnosed with a solid pseudopapillary neoplasm localized to the pancreatic tail. The patient underwent an open distal pancreatectomy accompanied by splenectomy, and histopathological examination confirmed the diagnosis of SPN. Their case underscores the possibility of SPN occurring in adolescent girls and points out the vital importance of early diagnosis and timely intervention, which can significantly enhance clinical outcomes. Although case report accompanied with some limitations for any conclusions, their report is interesting for journal readers in this field."  [Collapse]
Sapkota A, Paudel R, Pandey S, Bhatt N. Solid pseudopapillary neoplasm of the pancreas in an adolescent: A case report and review of the literature. World J Gastrointest Oncol 2025; 17(3): 101859
6
"Authors: Geng JX, Lu YF, Zhou JN, Huang B, Qin Y.  Article title: Exosome technology: A novel and effective drug delivery system ..."  [Read more]
"Authors: Geng JX, Lu YF, Zhou JN, Huang B, Qin Y.  Article title: Exosome technology: A novel and effective drug delivery system in the field of cancer therapy. The biocompatibility, targeting specificity, and low immunogenicity of exosomes render them as optimal carriers for drug delivery, enabling precise administration of therapeutics to diseased tissues, thereby achieving targeted treatment of cancer cells. However, the clinical application of exosome drug delivery platforms in oncology still presents challenges, necessitating further optimization to ensure their stability and efficacy. Their study focuses on elucidating the advantages of exosomes as a drug delivery platform, exploring the utilization of mesenchymal stem cell-derived exosomes in oncology therapy, and discussing their potential and future directions in cancer treatment. This letter is indicative."  [Collapse]
Geng JX, Lu YF, Zhou JN, Huang B, Qin Y. Exosome technology: A novel and effective drug delivery system in the field of cancer therapy. World J Gastrointest Oncol 2025; 17(3): 101857
7
"Authors: Rama NJG, Sousa I.  Article title: Bridging the gap: The role of technological advances in shaping gastrointestinal ..."  [Read more]
"Authors: Rama NJG, Sousa I.  Article title: Bridging the gap: The role of technological advances in shaping gastrointestinal oncological outcomes.  Their Editorial provides a comprehensive overview of the impact of technological advances vs current state-of-the-art practices in gastrointestinal oncology, highlighting the usefulness of combining new technologies with evidence-based clinical practices to improve patient outcomes. This letter is indicative."  [Collapse]
Rama NJG, Sousa I. Bridging the gap: The role of technological advances in shaping gastrointestinal oncological outcomes. World J Gastrointest Oncol 2025; 17(3): 101752
8
"Authors: Liu GJ, Long XY, Zhang F, Ren T, Xia X.  Article title: Heterochronic gastric adenosquamous carcinoma combined with colonic ..."  [Read more]
"Authors: Liu GJ, Long XY, Zhang F, Ren T, Xia X.  Article title: Heterochronic gastric adenosquamous carcinoma combined with colonic adenoma: A case report.  The common type of gastric cancer is adenocarcinoma, but the pathological type of gastric adenosquamous carcinoma is rare, so metachronous gastric adenosquamous carcinoma with signet ring cell carcinoma is even rarer. The metachronous tumors after esophageal cancer surgery are mostly found in the stomach, head and neck, but those occurring in the stomach and distal colon at the same time are rare. Although case report accompanied with some limitations for any conclusions, their report is interesting for journal readers in this field."  [Collapse]
Liu GJ, Long XY, Zhang F, Ren T, Xia X. Heterochronic gastric adenosquamous carcinoma combined with colonic adenoma: A case report. World J Gastrointest Oncol 2025; 17(3): 101734
9
"Authors: Erdogan B, Usturalı Keskin FE, Özcan E, Küçükarda A, Güren AK, Köstek O, Hacioglu BM, Kodaz H.  Article title: Assessment ..."  [Read more]
"Authors: Erdogan B, Usturalı Keskin FE, Özcan E, Küçükarda A, Güren AK, Köstek O, Hacioglu BM, Kodaz H.  Article title: Assessment of new pathological markers in early stage colon cancer: Insights and limitations.  When their associations with the pathological marker in the risk group were evaluated, it was found that there was a significant correlation between the presence of poorly differentiated clusters (PDC) and the presence of PDC grade 3 and advanced T stage. Their results showed us that PDC is one of the markers to be used in cases where these risk factors are insufficient. Although their study design accompanied with some limitations for any conclusions, their results were informative for journal readers."  [Collapse]
Erdogan B, Usturalı Keskin FE, Özcan E, Küçükarda A, Güren AK, Köstek O, Hacioglu BM, Kodaz H. Assessment of new pathological markers in early stage colon cancer: Insights and limitations. World J Gastrointest Oncol 2025; 17(3): 101325
10
"Authors: Song JH, Choi SY, Kim YS, Yang SY, Han KD.  Article title: Increased risk of colorectal cancer in young males with higher ..."  [Read more]
"Authors: Song JH, Choi SY, Kim YS, Yang SY, Han KD.  Article title: Increased risk of colorectal cancer in young males with higher cardiovascular risk: A nationwide population-based cohort study. While studies have reported an association between cardiovascular disease (CVD) and colorectal cancer (CRC), large-scale investigations on the incidence of CRC based on the risk of CVD are lacking. Their study benefits from being a nationwide population-based cohort study with long-term follow-up data spanning 10 years, which is a significant strength. Their study highlights that increased cardiovascular risk scores are significantly associated with higher CRC risk, especially among males and younger populations. Thus, males with a higher cardiovascular risk score, even at a younger age, are recommended to control their risk factors and undergo individualized CRC screening. Although their study design accompanied with some limitations for any conclusions, their results were informative for journal readers."  [Collapse]
Song JH, Choi SY, Kim YS, Yang SY, Han KD. Increased risk of colorectal cancer in young males with higher cardiovascular risk: A nationwide population-based cohort study. World J Gastrointest Oncol 2025; 17(3): 101260
11
"Authors: Bao ZC, Zhang Y, Liu ZD, Dai HJ, Ren F, Li N, Lv SY, Zhang Y.  Article title: Tetrahydrocurcumin-induced apoptosis of ..."  [Read more]
"Authors: Bao ZC, Zhang Y, Liu ZD, Dai HJ, Ren F, Li N, Lv SY, Zhang Y.  Article title: Tetrahydrocurcumin-induced apoptosis of hepatocellular carcinoma cells involves the TP53 signaling pathway, as determined by network pharmacology. Their study investigated the molecular mechanisms by which tetrahydrocurcumin (THC), a derivative of curcumin, inhibits hepatocellular carcinoma cells. Utilizing a comprehensive approach that integrated network pharmacology, molecular docking, and in vitro experiments, the TP53 signaling pathway was identified as a critical mediator of the antitumor activity of THC. Their results are informative for journal readers in this field."  [Collapse]
Bao ZC, Zhang Y, Liu ZD, Dai HJ, Ren F, Li N, Lv SY, Zhang Y. Tetrahydrocurcumin-induced apoptosis of hepatocellular carcinoma cells involves the TP53 signaling pathway, as determined by network pharmacology. World J Gastrointest Oncol 2025; 17(3): 101174
12
"Authors: Zhuang ZN, Zhao R, Li YX.  Article title: Retrospective analysis of factors influencing the self-healing of patients with ..."  [Read more]
"Authors: Zhuang ZN, Zhao R, Li YX.  Article title: Retrospective analysis of factors influencing the self-healing of patients with enterocutaneous fistulas receiving conservative treatment.  Enterocutaneous (EC) fistulas can cause various complications, such as infections, fluid loss, internal homeostasis imbalance, organ dysfunction, malnutrition, and other changes. Their study aimed to improve treatment outcomes for patients with EC fistulas and reduce the need for reoperation. The cure rate of patients with a single EC fistula can be effectively improved via conservative treatment combined with the use of biological fibrin glue to seal the fistula. Although their study design accompanied with some limitations for any conclusions, their results were informative for journal readers."  [Collapse]
Zhuang ZN, Zhao R, Li YX. Retrospective analysis of factors influencing the self-healing of patients with enterocutaneous fistulas receiving conservative treatment. World J Gastrointest Oncol 2025; 17(3): 101076
13
"Authors: Yuan Z, Wang JH, Cui H, Wang SY, Wei B, Cui JX.  Aticle title: Mapping the landscape of gastric cancer immunotherapy: ..."  [Read more]
"Authors: Yuan Z, Wang JH, Cui H, Wang SY, Wei B, Cui JX.  Aticle title: Mapping the landscape of gastric cancer immunotherapy: Bibliometric insights into advances and hotspots.  Their study employs bibliometric analysis to systematically elucidate the landscape of gastric cancer (GC) immunotherapy literature. Immunotherapy for GC has become a prominent research area, consistently attracting scientific scrutiny. Principal research topics include the prognostic evaluation of immunotherapy, immune microenvironment dynamics, synergistic strategies with targeted therapy, adoptive immunotherapy strategies, and the immunological treatment of gastroesophageal junction cancer. These topics continue to be at the forefront of current research initiatives. This document is indicative for journal readers in this field."  [Collapse]
Yuan Z, Wang JH, Cui H, Wang SY, Wei B, Cui JX. Mapping the landscape of gastric cancer immunotherapy: Bibliometric insights into advances and hotspots. World J Gastrointest Oncol 2025; 17(3): 100997
14
"Authors: Li TH, Sun X, Li CG, Yin YP, Tao KX.  Article title: Hypercoagulation after neoadjuvant immunochemotherapy as a new ..."  [Read more]
"Authors: Li TH, Sun X, Li CG, Yin YP, Tao KX.  Article title: Hypercoagulation after neoadjuvant immunochemotherapy as a new prognostic indicator in patients with locally advanced gastric cancer undergoing surgery. Their retrospective study assessed the correlation between hypercoagulation after neoadjuvant immunochemotherapy (NICT) and the prognosis of patients with locally advanced gastric cancer (LAGC). Results indicated that the non-hypercoagulation group exhibited significantly superior overall survival (OS) and disease-free survival (DFS) rates compared with the hypercoagulation group. Furthermore, multivariate analysis revealed that hypercoagulation after NICT was an independent risk factor for adverse postoperative OS and DFS. Their results suggests that hypercoagulation after NICT is an independent prognostic indicator of LAGC and may be used to evaluate therapeutic effects. Although their study design was retrospective, their results were interesting for journal readers in this field."  [Collapse]
Li TH, Sun X, Li CG, Yin YP, Tao KX. Hypercoagulation after neoadjuvant immunochemotherapy as a new prognostic indicator in patients with locally advanced gastric cancer undergoing surgery. World J Gastrointest Oncol 2025; 17(3): 100927
15
"Authors: Hao MZ, Lin HL, Hu YB, Chen QZ, Chen ZX, Qiu LB, Lin DY, Zhang H, Zheng DC, Fang ZT, Liu JF.  Article title: Combination ..."  [Read more]
"Authors: Hao MZ, Lin HL, Hu YB, Chen QZ, Chen ZX, Qiu LB, Lin DY, Zhang H, Zheng DC, Fang ZT, Liu JF.  Article title: Combination therapy strategy based on selective internal radiation therapy as conversion therapy for inoperable giant hepatocellular carcinoma: A case report.  Although selective internal radiation therapy (SIRT) has been used to treat unresectable hepatic cancers for more than 20 years, it is mainly employed to treat patients with ≤ 8 cm tumor size. Their research reports a hepatocellular carcinoma patient with > 15 cm hepatic mass, microvascular invasion, and China Liver Cancer Staging (CNLC) IIIa who received radical hepatectomy after successful conversion therapy with SIRT using yttrium-90 resin microspheres followed by hepatic arterial infusion chemotherapy using anti-programmed death-1 antibody and tyrosine kinase inhibitor. After 4 months of SIRT, the tumor was downstaged to CNLC Ib and the future liver remnant increased from 434 mL to 802 mL. Although case report accompanied with some limitations for any conclusions, their case report is interesting for journal readers in this field."  [Collapse]
Hao MZ, Lin HL, Hu YB, Chen QZ, Chen ZX, Qiu LB, Lin DY, Zhang H, Zheng DC, Fang ZT, Liu JF. Combination therapy strategy based on selective internal radiation therapy as conversion therapy for inoperable giant hepatocellular carcinoma: A case report. World J Gastrointest Oncol 2025; 17(3): 100861
16
"Author: Sun HT.  Article title: Helicobacter pylori-related serum indicators: Cutting-edge advances to enhance the efficacy of gastric ..."  [Read more]
"Author: Sun HT.  Article title: Helicobacter pylori-related serum indicators: Cutting-edge advances to enhance the efficacy of gastric cancer screening. Traditional serum tumor markers exhibit low diagnostic efficacy. Although gastrin and pepsin reflect the current state of the stomach, their clinical application remains impractical. New molecular biomarkers, such as noncoding genomes, have potential utility in diagnosing and screening for gastric cancer (GC); however, further validation is required. Serum anti-Helicobacter pylori antibodies have been used in various combined examination methods for GC screening, and the relationship between specific antibodies to virulence factors and GC risk has been thoroughly researched. The application of multiple serological detection and prediction models has expanded the pool of candidate biomarkers for GC screening. This review article is well written, and is informative for journal readers in this field."  [Collapse]
Sun HT. Helicobacter pylori-related serum indicators: Cutting-edge advances to enhance the efficacy of gastric cancer screening. World J Gastrointest Oncol 2025; 17(3): 100739
17
"Authors: Zhou J, Chen JR, Li JM, Han SQ, Deng XY, Li ZM, Tong W, Wang C, Bai Y, Zhang YM.  Article title: IL-22/IL-22R1 pathway ..."  [Read more]
"Authors: Zhou J, Chen JR, Li JM, Han SQ, Deng XY, Li ZM, Tong W, Wang C, Bai Y, Zhang YM.  Article title: IL-22/IL-22R1 pathway enhances cholangiocarcinoma progression via ERK1/2 activation. Their research results showed that IL-22R1 is highly expressed in cholangiocarcinoma (CCA) cell lines and tissues. The binding of IL-22 to IL-22R1 forms the IL-22/IL-22R1 axis, which can promote the progression of CCA both in vivo and in vitro. The application of ERK1/2 inhibitors can reverse the promoting effect of IL-22 on CCA, providing potential therapeutic strategies for CCA’s clinical treatment. Their results are informative for journal readers in this field."  [Collapse]
Zhou J, Chen JR, Li JM, Han SQ, Deng XY, Li ZM, Tong W, Wang C, Bai Y, Zhang YM. IL-22/IL-22R1 pathway enhances cholangiocarcinoma progression via ERK1/2 activation. World J Gastrointest Oncol 2025; 17(3): 102083
18
"Authors: Kotelevets SM, Chukov SZ.  Article title: Gastric cancer diagnosis and prevention: Detecting precancerous at community ..."  [Read more]
"Authors: Kotelevets SM, Chukov SZ.  Article title: Gastric cancer diagnosis and prevention: Detecting precancerous at community level.  They present a consistent system of population-based serological screening for precancerous diseases and changes in the gastric mucosa as a first-line screening strategy. The use of modern endoscopic and morphological diagnostic methods to verify pre-cancerous pathology of the stomach is recommended as a second line of screening for precancerous condition of the stomach. A detailed description of the markers of these pathological changes is given in the manuscript. Recent advances in research to identify the risk factors for stomach cancer have made it possible to use specific science to predict this deadly disease. This letter is indicative."  [Collapse]
Kotelevets SM, Chukov SZ. Gastric cancer diagnosis and prevention: Detecting precancerous at community level. World J Gastrointest Oncol 2025; 17(3): 100521
19
"Authors: Liu Y, Li XF.  Articlew title: Characteristics and therapeutic strategies for familial gastrointestinal stromal tumors. The ..."  [Read more]
"Authors: Liu Y, Li XF.  Articlew title: Characteristics and therapeutic strategies for familial gastrointestinal stromal tumors. The management of familial gastrointestinal stromal tumors (GISTs) depends on the conduct of genetic surveillance, with early screening for first-degree relatives being essential. Current treatment strategies are essentially the same as those used for sporadic GISTs, primarily consisting of surgery and tyrosine kinase inhibitor targeted therapy. For familial GISTs, additional experience and evidence are required for treatment, prognosis, and monitoring; therefore, it is advisable to adopt more proactive therapeutic and follow-up strategies. This letter is indicative."  [Collapse]
Liu Y, Li XF. Characteristics and therapeutic strategies for familial gastrointestinal stromal tumors. World J Gastrointest Oncol 2025; 17(3): 100463
20
"Author: Sukocheva OA.  Article title: Resveratrol and pancreatic cancers: Questions and future perspectives. A promising new ..."  [Read more]
"Author: Sukocheva OA.  Article title: Resveratrol and pancreatic cancers: Questions and future perspectives. A promising new direction for the treatment of pancreatic cancer has been investigated and reported by Jiang et al. Using immunohistochemistry, the authors assessed pancreatic cancer tissues and detected the presence of senescent cancer-associated fibroblasts (CAFs) in the tumor microenvironment. Following this, they observed the ability of the natural polyphenolic compound resveratrol to reverse the senescent CAF phenotype and inhibit pancreatic cancer progression in vitro and in vivo. This editorial assesses important aspects of the original article and discusses future perspectives of resveratrol-containing therapy. This letter is indicative."  [Collapse]
Sukocheva OA. Resveratrol and pancreatic cancers: Questions and future perspectives. World J Gastrointest Oncol 2025; 17(3): 100342
15465 items  Read more >>
Peer-Reviewers and Manuscript Statistics
Editorial board members
2266
Peer-reviewers
32188
Manuscripts received today
5
Manuscript reviews today
12
Unhandled manuscripts today
157
Active peer-reviewers today
611
Reviewer acceptance today
13
Reviewer refusals today
14
Total accepted manuscripts
36764
Total rejected manuscripts
42272
Total peer-reviewers
4279992
Total submissions
34910
Baishideng Publishing Group (BPG) publishes 47 peer-reviewed, open-access journals covering a broad range of topics in clinical medicine, as well as several topics in biochemistry and molecular biology, relevant to human health today.
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All Journal Articles
1

Parchwani D, Singh R, Patel D. Biological and translational attributes of mitochondrial DNA copy number: Laboratory perspective to clinical relevance. World J Methodol 2025; 15(3): 102709

2025-09-20 | Browse: 4670 | Download: 723
2

Tawheed A, Ismail A, El-Tawansy A, Maurice K, Ali A, El-Fouly A, Madkour A. Third space endoscopy pulmonary complications and chylothorax post peroral endoscopic myotomy. World J Methodol 2025; 15(3): 102703

2025-09-20 | Browse: 4488 | Download: 718
3

Bajpai J, Saxena M, Pradhan A, Kant S. Sotatercept: A novel therapeutic approach for pulmonary arterial hypertension through transforming growth factor-β signaling modulation. World J Methodol 2025; 15(3): 102688

2025-09-20 | Browse: 5342 | Download: 674
4

Bale BI, Zeppieri M, Idogen OS, Okechukwu CI, Ojo OE, Femi DA, Lawal AA, Adedeji SJ, Manikavasagar P, Akingbola A, Aborode AT, Musa M. Seeing the unseen: The low treatment rate of eye emergency in Africa. World J Methodol 2025; 15(3): 102477

2025-09-20 | Browse: 5164 | Download: 759
5

Vo LT, Vu T, Pham TN, Trinh TH, Nguyen TT. Machine learning-based models for prediction of in-hospital mortality in patients with dengue shock syndrome. World J Methodol 2025; 15(3): 101837

2025-09-20 | Browse: 4740 | Download: 1004
6

Chauhan R, Padiyar N, Kaurani P, Gupta A, Chauhan S. Comparative evaluation of retentive capacity of three different attachment systems for implant retained overdentures: An in vitro study. World J Methodol 2025; 15(3): 101057

2025-09-20 | Browse: 4919 | Download: 861
7

Shah P, Shah VM, Saravanan VR, Kumar K, Narendran S. Evaluation of macular and peripapillary structure and microvasculature with optical coherence tomography angiography in migraine in Indian population. World J Methodol 2025; 15(3): 100950

2025-09-20 | Browse: 4634 | Download: 967
8

Drăgoi AL, Nemeș RM. “Electronic Pediatrician”, a non-machine learning prototype artificial intelligence software for pediatric computer-assisted pathophysiologic diagnosis — general presentation. World J Methodol 2025; 15(3): 100903

2025-09-20 | Browse: 4623 | Download: 917
9

Drăgoi AL, Nemeș RM. The remarkable effects of the ionized medical water Asea® in 3 boys with Duchenne dystrophy: Three case reports. World J Methodol 2025; 15(3): 100840

2025-09-20 | Browse: 5728 | Download: 808
10

Fawaz P, El Sayegh P, Vande Vannet B. Artificial intelligence in revolutionizing orthodontic practice. World J Methodol 2025; 15(3): 100598

2025-09-20 | Browse: 7451 | Download: 872
11

Khokhar RK, Nashwan AJ. Gut virome and its emerging role in inflammatory bowel disease. World J Methodol 2025; 15(3): 100534

2025-09-20 | Browse: 3330 | Download: 676
12

English K. Echo contrast medium: How the use of contrast echocardiography (ultrasound contrast agents) can improve patient care. World J Methodol 2025; 15(3): 100490

2025-09-20 | Browse: 4124 | Download: 671
13

Tramontana A, Rulli M, Falegnami A, Bilotta F. Visual avatar to increase situational awareness in anaesthesia: Systematic review of recent evidence. World J Methodol 2025; 15(3): 100459

2025-09-20 | Browse: 4558 | Download: 723
14

Li XL, Megdadi M, Quadri HS. Interaction between gut virome and microbiota on inflammatory bowel disease. World J Methodol 2025; 15(3): 100332

2025-09-20 | Browse: 3330 | Download: 589
15

Raveendran AV. Clinical inertia in sexual medicine practice. World J Methodol 2025; 15(3): 99874

2025-09-20 | Browse: 4398 | Download: 643
16

Tarazi A, Aburrub A, Hijah M. Use of artificial intelligence in neurological disorders diagnosis: A scientometric study. World J Methodol 2025; 15(3): 99403

2025-09-20 | Browse: 5613 | Download: 829
17

Casu C, Inchingolo AM, Orrù G. Interleukin 10 supplement to reduce episodes of recurrent aphthous stomatitis. World J Methodol 2025; 15(3): 99176

2025-09-20 | Browse: 4144 | Download: 636
18

Singh K, Nashwan AJ. Innovative forecasting models for nurse demand in modern healthcare systems. World J Methodol 2025; 15(3): 99162

2025-09-20 | Browse: 3622 | Download: 631
19

Kodali R, Parasar K, Anand U, Singh BN, Kant K, Arora A, Karthikeyan V, Anwar S, Saha B, Wadaskar S. Evidence-based approach for intraabdominal drainage in pancreatic surgery: A systematic review and meta-analysis. World J Methodol 2025; 15(3): 99080

2025-09-20 | Browse: 4800 | Download: 855
20

Al-Beltagi M. Fishing reviewing: A threat to research integrity and credibility. World J Methodol 2025; 15(3): 98795

2025-09-20 | Browse: 3885 | Download: 678
59143 items  Read more >>
Featured Articles
1

Leopoldo K, Castaldelli-Maia JM. Empowering older adults: Enhancing addiction literacy to address unique vulnerabilities. World J Psychiatry 2025; 15(7): 104254

2025-07-10 | Browse: 1 | Download: 2
2

Jiang L, Ma RX, He ES, Zheng XY, Peng X, Ma WH, Li Y, Li HW, Zhang XY, Ji JY, Li YJ, Qu SL, Li LJ, Gong ZT. DNA methylation regulates the extinction of fear memory. World J Psychiatry 2025; 15(7): 107524

2025-07-10 | Browse: 2 | Download: 1
3

Wen Y, Zhang QX, Liu Y, He XH, Gong YW. Relationship between death anxiety and coping with death competence among Chinese oncology nurses: A chain mediation model. World J Psychiatry 2025; 15(7): 107416

2025-07-10 | Browse: 3 | Download: 1
4

Li DX, Hu QM, Xu CC, Yang HY, Liu JK, Sun YF, Wang G, Wang J, Zhou ZH. Efficacy of Pediococcus acidilactici CCFM6432 in alleviating anhedonia in major depressive disorder: A randomized controlled trial. World J Psychiatry 2025; 15(7): 105249

2025-07-10 | Browse: 1 | Download: 0
5

Yıldırım SA, Dal I, Özkan-Kotiloğlu S, Baskak B, Kaya-Akyüzlü D. Pharmacoepigenetics in schizophrenia: Predicting drug response. World J Psychiatry 2025; 15(7): 107597

2025-07-10 | Browse: 1 | Download: 3
6

Wu JR, Wang CC, Li BY, Li JH, Zhang T, Li ZY. Concomitant functional gallbladder disorder and left-sided gallbladder: A case report. World J Gastrointest Endosc 2025; 17(7): 107059

2025-07-09 | Browse: 15 | Download: 33
7

Gadour E, Miutescu B, Okasha HH, Albeshir M, Alamri T, Ghoneem E, Burciu C, Popa A, Koppandi O, AlQahtani MS. Evolving role of endoscopic ultrasound in biliary stricture management: A meta-analysis and systematic review. World J Gastrointest Endosc 2025; 17(7): 108541

2025-07-09 | Browse: 13 | Download: 9
8

Gadour E, Miutescu B, Okasha HH, Ghiuchici AM, AlQahtani MS. Diagnostic yield of video capsule endoscopy vs simple balloon enteroscopy in small intestinal disorders: A systematic review. World J Gastrointest Endosc 2025; 17(7): 108264

2025-07-09 | Browse: 14 | Download: 23
9

Li XR, Kong MW, Guan XF, Gao Y. Revolutionizing upper gastrointestinal disease diagnosis: The transformative role of artificial intelligence in endoscopy. World J Gastrointest Endosc 2025; 17(7): 108293

2025-07-09 | Browse: 12 | Download: 6
10

Singh H, Koh FHX. Golden vision: The potential of yellow enhancement in laparoscopic abdominal surgeries and surgical education. World J Gastrointest Endosc 2025; 17(7): 107872

2025-07-09 | Browse: 12 | Download: 30
11

AlSabea N, Syeda S, Gubran M, Gibatova V, Sharma R, Aswani A. Atypical presentation of a large posterior falx meningioma involving the parafalcine region in a 78-year-female: A case report. World J Clin Cases 2025; 13(25): 108429

2025-07-07 | Browse: 18 | Download: 39
12

Demirel S, Sinag IN. Role of nitric oxide, prostaglandins, thromboxanes and endothelins in lung cancer: An overview. World J Clin Cases 2025; 13(25): 107907

2025-07-07 | Browse: 15 | Download: 30
13

Ai MM, Lin T, Guo RY, Zhang YY, Yu F. Unexpected metastasis of thyroid cartilage involvement from lung adenocarcinoma: A case report. World J Clin Cases 2025; 13(25): 107471

2025-07-07 | Browse: 15 | Download: 53
14

Tanikawa T, Miyake K, Kawada M, Ishii K, Fushimi T, Urata N, Wada N, Nishino K, Suehiro M, Kawanaka M, Shiraha H, Haruma K, Fujiwara H, Yamatsuji T, Kawamoto H. Aneurysm rupture in median arcuate ligament syndrome leading to duodenal stenosis: A case report. World J Clin Cases 2025; 13(25): 106089

2025-07-07 | Browse: 16 | Download: 31
15

Liu H, Ke F, Li CZ, Li SP, He XQ, Lu H. Clinical application of radiofrequency technology in the treatment of facial skin wrinkles and laxity. World J Clin Cases 2025; 13(25): 97335

2025-07-07 | Browse: 15 | Download: 55
16

Wang CH, Zhai YQ. Additional considerations on a combination of inflammatory markers and scoring systems for early severity stratification of acute pancreatitis. World J Gastroenterol 2025; 31(25): 108943

2025-07-04 | Browse: 69 | Download: 121
17

Huang SS, Chen W, Vaishnani DK, Huang LJ, Li JZ, Huang SR, Li YZ, Xie QP. Leucine-rich repeat-containing protein 19 suppresses colorectal cancer by targeting cyclin-dependent kinase 6/E2F1 and remodeling immune microenvironment. World J Gastroenterol 2025; 31(25): 107893

2025-07-04 | Browse: 48 | Download: 150
18

Sun Q, Wu JC, Chen X, Li DH, Li BR, Xiao NJ, Wang XY, Tu XZ, Ning SB, Sun T. Efficacy and safety of sirolimus in the treatment of gastrointestinal angiodysplasias. World J Gastroenterol 2025; 31(25): 105677

2025-07-04 | Browse: 54 | Download: 108
19

Liguori A, Ainora ME, Di Gialleonardo L, Viceconti N, Petrucci L, Esposto G, Giustiniani MC, Mignini I, Borriello R, Galasso L, Paratore M, Garcovich M, Riccardi L, Pompili M, Grieco A, Gasbarrini A, Miele L, Zocco MA. Multiparametric ultrasound for non-invasive assessment of liver steatosis, fibrosis and inflammation in metabolic dysfunction-associated steatotic liver disease. World J Gastroenterol 2025; 31(25): 105518

2025-07-04 | Browse: 49 | Download: 134
20

Wang Q, Sun LN, Shi H, Ma XY, Gao W, Xu B, Lin X, Liu YM, Huang CY, Jin RH. Multi-omics analysis reveals gut microbiota-metabolite interactions and their association with liver function in autoimmune overlap syndrome. World J Gastroenterol 2025; 31(25): 106371

2025-07-04 | Browse: 50 | Download: 149
9657 items  Read more >>
Keyword Search Published Articles Processes
1
Case report
2853
2
Case report
1667
3
Hepatocellular carcinoma
1430
4
Gastric cancer
1005
5
Colorectal cancer
983
6
Inflammatory bowel disease
715
7
COVID-19
704
8
Prognosis
670
9
Liver transplantation
617
10
Ulcerative colitis
554
11
Treatment
552
12
Helicobacter pylori
517
13
Diagnosis
517
14
Crohn’s disease
513
15
Endoscopy
479
16
Cirrhosis
478
17
Meta-analysis
454
18
Pancreatic cancer
440
19
Magnetic resonance imaging
440
20
Surgery
423
69973 items  Read more >>
Reader Comments
1
"### Review of the Article “Multiparametric ultrasound for non-invasive assessment of liver steatosis, fibrosis, and inflammation in ..."  [Read more]
"### Review of the Article “Multiparametric ultrasound for non-invasive assessment of liver steatosis, fibrosis, and inflammation in metabolic dysfunction-associated steatotic liver disease” published in the World Journal of Gastroenterology This article represents a significant advancement in the non-invasive diagnosis of metabolic dysfunction-associated steatotic liver disease (MASLD) and offers valuable insights for clinical practice. #### Clinical Application Value The study introduces a non-invasive assessment method based on multiparametric ultrasound, which holds great significance for clinical practice. Given the large number of MASLD patients, traditional liver biopsy is not only costly but also associated with sampling errors and risks of complications. The introduction of multiparametric ultrasound provides clinicians with a safer and more convenient diagnostic tool, effectively reducing the need for liver biopsies and minimizing patient discomfort and medical costs. #### Innovation For the first time, this study compares viscosity measurements (Vi.PLUS) with the histopathological features of MASLD and finds that viscosity is closely related to the degree of inflammation and ballooning in MASH. This finding offers a new perspective for the non-invasive diagnosis of MASLD and paves the way for future research and clinical applications. #### Methodological Rigor The study employs a single-center, prospective, cross-sectional design with 120 patients, all of whom underwent liver biopsy as the reference standard. This rigorous study design and methodology ensure the reliability and scientific validity of the results. #### Practicality of the Results The study demonstrates that the VAS-MASH-US score, based on multiparametric ultrasound, has good sensitivity and specificity for diagnosing MASH. This scoring system provides clinicians with a practical tool to better identify high-risk patients who need liver biopsy, while reducing unnecessary invasive examinations for low-risk patients. #### Limitations of the Study Despite the significant findings, the study has some limitations. For example, it is a single-center study with a relatively small sample size, and the results have not yet been validated in an independent cohort. Additionally, differences in ultrasound equipment and techniques across centers may affect the generalizability of the results. #### Implications for Future Research This study provides new ideas and methods for the non-invasive diagnosis of MASLD, but further research is needed to validate these findings. For instance, multicenter studies in larger populations could verify the universality and accuracy of the VAS-MASH-US score. Moreover, exploring the combination of other non-invasive techniques with multiparametric ultrasound could further improve the diagnostic accuracy of MASLD. In summary, this article represents an important step forward in the non-invasive diagnosis of MASLD. Its innovation and practicality are commendable. It is hoped that more research will be conducted in the future to further refine this field and provide better medical services for MASLD patients. "  [Collapse]
Liguori A, Ainora ME, Di Gialleonardo L, Viceconti N, Petrucci L, Esposto G, Giustiniani MC, Mignini I, Borriello R, Galasso L, Paratore M, Garcovich M, Riccardi L, Pompili M, Grieco A, Gasbarrini A, Miele L, Zocco MA. Multiparametric ultrasound for non-invasive assessment of liver steatosis, fibrosis, and inflammation in metabolic dysfunction-associated steatotic liver disease. World J Gastroenterol 2025; 31(25): 105518
2
"Good case report of involvement of thyroid cartilage, however, it is a very rare incidence. Language quality is good. Content is ok ..."  [Read more]
"Good case report of involvement of thyroid cartilage, however, it is a very rare incidence. Language quality is good. Content is ok IHC report images should also be included to solidify the diagnosis and not just mentioning the report of IHC findings. Study stated to look for the distant metastasis including the thyroid/cartilage. However, hematogenous spread to more common distant organ should be more focused on rather than the rare ones. Especially-- liver, bone etc. Metastasis to thyroid cartilage- a poor prognostic factor--mentioned in the study. However, could not get any information/data for that "  [Collapse]
Ai MM, Lin T, Guo RY, Zhang YY, Yu F. Unexpected metastasis of thyroid cartilage involvement from lung adenocarcinoma: A case report. World J Clin Cases 2025; 13(25): 107471
3
"Good case report of involvement of thyroid cartilage, however, it is a very rare incidence. Language quality is good. Content is ok ..."  [Read more]
"Good case report of involvement of thyroid cartilage, however, it is a very rare incidence. Language quality is good. Content is ok IHC report images should also be included to solidify the diagnosis and not just mentioning the report of IHC findings. Study stated to look for the distant metastasis including the thyroid/cartilage. However, hematogenous spread to more common distant organ should be more focused on rather than the rare ones. Especially-- liver, bone etc. Metastasis to thyroid cartilage- a poor prognostic factor--mentioned in the study. However, could not get any information/data for that. "  [Collapse]
Ma TT, Lyu HR. Post-endoscopic retrograde appendicitis therapy stent impaction leading to exacerbation of appendicitis: A case report. World J Clin Cases 2025; 13(25): 106587
4
"tertiary care hospital over the last 7 years from the Himalayan and Sub-Himalayan regions of India. Studys aim--To analyze the ..."  [Read more]
"tertiary care hospital over the last 7 years from the Himalayan and Sub-Himalayan regions of India. Studys aim--To analyze the demography, clinical presentation, complications, and mortality risk factors in presumptive leptospirosis patients admitted--- was fulfilled, however, limited to one single center study and observation only. 2018-2024 data were collected based on Modified Faine’s criteria with ELISA diagnosis. \ Sample size is small. 62 number Study found- equal number of distribution of cases irrespective of sex. Complications include thrombocytopenia and liver involvement and AKI. MDS was serious complication observed in 66% of cases. Studies have also highlighted that early administration of antibiotics and aggressive supportive care can improve survival outcomes in critically ill patients with leptospirosis Limitation—only single center study with possible some selection bias. Overall Language quality and content-- Excellent. "  [Collapse]
Das D, Ponnampurathu S, Panda PK, Mathuria YP. Different clinical profile of leptospirosis in a tertiary care Indian hospital: A Himalayan experience. World J Clin Cases 2025; 13(25): 106335
5
"Study conducted from 1985 to 2022--total 47 patients included with PDTC. some of them lost on follow up. Good analysis of risk factors ..."  [Read more]
"Study conducted from 1985 to 2022--total 47 patients included with PDTC. some of them lost on follow up. Good analysis of risk factors and outcome. Good standard of article The scientific quality of very good The language quality is also professional and clear. The data analysis and charts are upto the mark. "  [Collapse]
Hsu CW, Hsueh C, Lu YL, Hsu CJ, Wong RJ, Lin SF. Risk factors and outcomes of metastatic poorly differentiated thyroid carcinoma. World J Clin Cases 2025; 13(25): 105204
6
"This paper reports on a clinical trial assessing the efficacy and safety of sirolimus in the treatment of gastrointestinal ..."  [Read more]
"This paper reports on a clinical trial assessing the efficacy and safety of sirolimus in the treatment of gastrointestinal angiodysplasia (GIAD). The results indicate that sirolimus is effective in reducing bleeding, improving hemoglobin levels, decreasing transfusion dependence, and improving lesion outcomes. Additionally, the adverse effects were mild and manageable. However, it should be noted that while patients with various underlying conditions were included, those with chronic kidney disease were not represented. This is a concern, as patients with chronic kidney disease often experience recurrent gastrointestinal bleeding due to angiodysplasia. Further studies involving a larger number of patients, including those with chronic kidney disease, are warranted. "  [Collapse]
Sun Q, Wu JC, Chen X, Li DH, Li BR, Xiao NJ, Wang XY, Tu XZ, Ning SB, Sun T. Efficacy and safety of sirolimus in the treatment of gastrointestinal angiodysplasias. World J Gastroenterol 2025; 31(25): 105677
7
"This paper provides an interesting exploration of the gut microbiota and its potential role in autoimmune overlap syndrome (OS), ..."  [Read more]
"This paper provides an interesting exploration of the gut microbiota and its potential role in autoimmune overlap syndrome (OS), combining features of autoimmune hepatitis (AIH) and primary biliary cholangitis (PBC). The study integrates multi-omics data, focusing on microbial profiles and serum metabolites, to provide new insights into the pathophysiology of OS. The findings are clinically relevant, particularly in the context of identifying biomarkers for earlier and non-invasive diagnosis of OS, which could improve clinical management. However, the study is limited by its small sample size and lack of a healthy control group, which restricts the generalizability of the results. Despite these limitations, the paper opens up promising avenues for future research in microbiota-based diagnostics and therapeutic strategies for autoimmune liver diseases. "  [Collapse]
Wang Q, Sun LN, Shi H, Ma XY, Gao W, Xu B, Lin X, Liu YM, Huang CY, Jin RH. Multi-omics analysis reveals gut microbiota-metabolite interactions and their association with liver function in autoimmune overlap syndrome. World J Gastroenterol 2025; 31(25): 106371
8
"This study presents a comprehensive investigation into the use of multiparametric ultrasound (US) for the non-invasive assessment ..."  [Read more]
"This study presents a comprehensive investigation into the use of multiparametric ultrasound (US) for the non-invasive assessment of liver steatosis, fibrosis, and inflammation in patients with metabolic dysfunction-associated steatotic liver disease (MASLD). The authors employed various advanced ultrasound techniques, including 2D shear-wave elastography (SWE), sound speed and attenuation imaging, and viscosity plane-wave ultrasound (Vi.PLUS), alongside traditional methods like FibroScan. The study's findings are promising, demonstrating that multiparametric ultrasound can effectively assess liver conditions such as fibrosis and steatosis, and even disease activity related to inflammation and ballooning. The diagnostic performance of the viscosity index (Vi.PLUS) and the VAS-MASH-US score was found to be good, especially for identifying patients with metabolic dysfunction-associated steatohepatitis (MASH). This approach could help reduce unnecessary liver biopsies, thereby minimizing costs and procedural risks, which is a significant clinical advantage. "  [Collapse]
Liguori A, Ainora ME, Di Gialleonardo L, Viceconti N, Petrucci L, Esposto G, Giustiniani MC, Mignini I, Borriello R, Galasso L, Paratore M, Garcovich M, Riccardi L, Pompili M, Grieco A, Gasbarrini A, Miele L, Zocco MA. Multiparametric ultrasound for non-invasive assessment of liver steatosis, fibrosis, and inflammation in metabolic dysfunction-associated steatotic liver disease. World J Gastroenterol 2025; 31(25): 105518
9
"Hepatocellular carcinoma (HCC) remains a major global health burden, ranking as the sixth most common cancer and the third leading ..."  [Read more]
"Hepatocellular carcinoma (HCC) remains a major global health burden, ranking as the sixth most common cancer and the third leading cause of cancer-related mortality worldwide. Despite advances in surveillance, early diagnosis, and the emergence of molecular-targeted and immunotherapeutic agents, the prognosis for many patients with HCC remains poor. This is particularly true in advanced-stage disease, where therapeutic resistance and immune escape mechanisms hinder durable responses. As our understanding of HCC pathogenesis deepens, the tumor microenvironment (TME) has emerged as a critical determinant of disease progression and therapeutic outcome. Among the key regulators in this microenvironment are galectins (Gals)—a family of glycan-binding proteins with various immunomodulatory and tumor-regulatory functions. Gal-1, Gal-3, Gal-4, and Gal-9 have attracted significant attention for their diverse roles in HCC. These proteins guide important cellular processes vital for tumor development, including inflammation, immune evasion, angiogenesis, epithelial–mesenchymal transition (EMT), proliferation, and metastasis. What sets galectins apart is their functional duality—their effects depend on their cellular location, expression levels, and the tumor microenvironment (TME). This complexity highlights their potential as both biomarkers and therapeutic targets in HCC. They coordinate processes like inflammation, angiogenesis, EMT, tumor growth, and spread. Importantly, galectins display dynamic, context-dependent behavior, capable of exerting both tumor-promoting and tumor-inhibiting effects depending on their expression, cellular localization, and the surrounding microenvironment. Recent studies, including the comprehensive review by Gajovic and colleagues (WJG 2025; 31:107260), highlight the diverse functions of Galectins in liver cancer. For instance, Gal-1 and Gal-3 are consistently associated with aggressive tumor features such as vascular invasion, immunosuppression, and poor prognosis. Conversely, Gal-4 and Gal-9 appear as favorable prognostic indicators in specific HCC subtypes, possibly due to their roles in immune activation and metastasis suppression. This duality not only reflects the complexity of Galectin biology but also encourages the development of improved biomarkers and personalized therapeutic strategies. The current therapeutic landscape of HCC—although expanded by immune checkpoint inhibitors and molecularly targeted agents—remains inadequate for many patients, especially those with advanced disease. In this context, Galectin-targeted therapies show considerable promise. Gal-3 inhibitors and Gal-3C fusion proteins, for example, are actively being studied for their ability to reverse immune suppression, disrupt tumor–stromal interactions, and improve the effectiveness of existing treatments. Meanwhile, profiling Galectin expression may help predict treatment responses and guide personalized therapy strategies. Elevated levels of Gal-1 and Gal-3 in serum or tumor tissue have consistently been associated with aggressive clinical features, such as vascular invasion, immune evasion, and poor overall survival. Conversely, Gal-4 and Gal-9 expression have been linked to favorable prognostic indicators in some patient groups, highlighting the biological diversity of HCC and the complex roles that galectins play in disease progression. The therapeutic implications are equally compelling. Galectin-targeted agents—such as Gal-3 inhibitors and Gal-3C fusion proteins—are being studied for their ability to modify the TME, boost anti-tumor immunity, and overcome resistance to current therapies. At the same time, integrating galectin profiling into clinical practice could improve risk assessment, enhance prognostic models, and support more personalized treatment approaches. However, these promising advancements must be accompanied by rigorous clinical validation. The dual and sometimes conflicting roles of galectins in cancer emphasize the importance of context—what may be beneficial in one cellular environment could be detrimental in another. Large-scale, well-controlled clinical trials and mechanistic research are critical for fully understanding the therapeutic potential of galectin modulation in HCC. Galectins are an area of study within the field of HCC biology and therapeutics that has not been extensively researched. In addressing treatment resistance and disease heterogeneity, galectins have potential for the development of biomarkers and targeted therapies. Including galectins in future HCC management strategies may contribute to more effective and personalized treatment methods. "  [Collapse]
Gajovic NM, Jovanovic IP, Jocic MV, Stojanovic B, Corovic IF, Todorovic N, Simovic Markovic BJ, Amedei A. Exploring the impact of galectins on liver cancer: From immunopathogenesis to potential targets. World J Gastroenterol 2025; 31(25): 107260
10
"This study demonstrates that reduced NRF2 activity contributes to ER stress and senescence in adipose-derived mesenchymal stem cells ..."  [Read more]
"This study demonstrates that reduced NRF2 activity contributes to ER stress and senescence in adipose-derived mesenchymal stem cells (ASCs) from hypertrophic obese mice, primarily through downregulation of MFN2. The use of multiple approaches, including NRF2/MFN2 knockdown and rescue, ChIP-qPCR, Co-IP, immunofluorescence, and IP-MS, adds robustness to the findings. Importantly, the functional relevance is strengthened by transplantation experiments, showing that disruption of NRF2 or MFN2 impairs the therapeutic potential of ASCs in insulin resistance, highlighting translational significance. However, while the authors suggest an interaction between MFN2 and BIP, the evidence remains indirect. Biochemical confirmation such as GST pull-down or FRET would be needed to verify a direct interaction. Additionally, NRF2 may affect ER stress and senescence through other targets beyond MFN2, which were not explored in this study. Future work should aim to clarify the structural basis of MFN2–BIP interaction and its functional consequences. Given the known role of MFN2 in mitochondrial dynamics and ER-mitochondrial tethering, investigating how this axis influences mitochondrial morphology, mitochondria-associated membranes integrity, and calcium signaling could provide further mechanistic insights. "  [Collapse]
Fang J. Reduced NRF2/Mfn2 activity promotes endoplasmic reticulum stress and senescence in adipose-derived mesenchymal stem cells in hypertrophic obese mice. World J Stem Cells 2025; 17(6): 104367
11
"Dear Editor, I read with great interest the editorial by Papadakos et al. on the evolving immunotherapeutic landscape in ..."  [Read more]
"Dear Editor, I read with great interest the editorial by Papadakos et al. on the evolving immunotherapeutic landscape in gastrointestinal stromal tumors (GISTs). The authors provide a comprehensive overview of the tumor microenvironment (TME), challenges in immunotherapy response, and emerging strategies. I would like to offer several complementary insights and suggest future directions for translational and clinical research. 1. Stratifying GISTs Through Immune Profiling: The authors rightly emphasize the immunosuppressive TME in GISTs. Building on this, emerging evidence from proteomic and transcriptomic studies supports the existence of distinct immune clusters ranging from inflamed “hot” tumors (TLS⁺/B-cell-rich) to immune-desert “cold” phenotypes. These immune subtypes have shown clear prognostic and predictive value for checkpoint inhibitor response, with objective response rates reaching 50% in TLS-rich subgroups. Integration of spatial profiling and CXCL13 expression as biomarkers may refine patient selection for PD-1/PD-L1 blockade. 2. 2. Rationale for Combination Strategies: While the editorial correctly notes the modest activity of ICIs in unselected patients, combinatorial approaches offer promise. For example, pegylated interferon-alpha-2b (PegIFNα2b) in conjunction with imatinib significantly enhances immune infiltration and suppresses PI3K/mTOR signaling, achieving remarkable response rates in early trials. Similarly, imatinib’s ability to reverse immunosuppression via IDO downregulation and Treg reduction provides a mechanistic rationale for synergy with ICIs, particularly in PDGFRA D842V-mutant GISTs. 3. Targeting Tumor Antigens and TME Components: Antibody-based therapies like SR1 (anti-KIT) have demonstrated macrophage-dependent cytotoxicity even in imatinib-resistant models. This offers a novel route to bypass TKI resistance. Additionally, novel modalities such as bispecific antibodies targeting KIT or PDGFRA in conjunction with CD3⁺ T cell engagement may overcome immune exclusion in “cold” tumors. 4. Addressing IDO Inhibitor Failures: The editorial notes the challenges with IDO1-targeted therapies. We propose that resistance may stem from spatial heterogeneity and compensatory activation of AhR and TDO2 pathways. Poly-pathway blockade, rather than IDO inhibition alone, may be essential to overcome this resistance. 5. Moving Forward: Future success in GIST immunotherapy will depend on Immune subtyping based on TLS, B cell density, and proteomic clusters (Im-I to Im-IV), Rational combination trials of TKIs + ICIs ± TME-modifying agents, Validation of biomarkers such as CXCL13, CD276, and KIT-derived neoantigens in prospective cohorts. In conclusion, the editorial provides an excellent foundation for discourse. We advocate for multi-center, biomarker-driven clinical trials to translate these emerging insights into tailored immunotherapy regimens for GIST patients. Sincerely, Fen Wang Oncology Department, Peking University Shenzhen Hospital. "  [Collapse]
Papadakos SP, Argyrou A, Karniadakis I, Vogli S, Theocharis S. Immunotherapy in gastrointestinal stromal tumors: Current landscape and future horizons. World J Clin Oncol 2025; 16(6): 104314
12
"Pulmonary fibrosis (PF), a chronic and fatal lung disease affecting millions of people worldwide, urgently needs more effective means. ..."  [Read more]
"Pulmonary fibrosis (PF), a chronic and fatal lung disease affecting millions of people worldwide, urgently needs more effective means. In this paper, the effect of cells vesicles in improving PF was verified through cell lines and rat models, and the possible pathways through which this effect was exerted were investigated. Anyway, there are still some aspects of the article that deserve further discussion. Most importantly, whether the therapeutic effect is exerted through the said signaling pathway needs to be further confirmed. In addition, the text has problems such as writing errors, suspected incompleteness of ethics, and relatively weak research significance. "  [Collapse]
Wang LL, Ouyang MY, Yang ZE, Xing SN, Zhao S, Yu HY. Mesenchymal stem cells-derived exosomes alleviate radiation induced pulmonary fibrosis by inhibiting the protein kinase B/nuclear factor kappa B pathway. World J Stem Cells 2025; 17(6): 106488
13
"We read with great interest the work of Abdelsamie and colleagues, who describe the characteristics of acute myocardial infarction ..."  [Read more]
"We read with great interest the work of Abdelsamie and colleagues, who describe the characteristics of acute myocardial infarction (AMI) in young patients, including presentation, risk factors, coronary angiography findings, and management strategies.1 While AMI is predominantly observed in individuals over 45, its occurrence in younger adults has garnered increasing attention due to its distinct risk factors and long-term consequences. When it occurs, early-onset AMI is often associated with substantial morbidity, psychosocial impact, and economic burden for patients and their families.2 We commend the authors for addressing this important topic, we would like to offer several suggestions that may help to further strengthen the clarity and clinical applicability of the study. First, the Methods section of the manuscript appears concise and would benefit from additional details to enhance reproducibility. Specifically, the Subjects subsection could provide a more comprehensive account of the exclusion criteria. While inclusion criteria are described, it remains unclear whether important conditions, such as severe cardiomyopathy, rheumatic heart disease, or malignancy, were excluded. Clarifying these aspects would strengthen the credibility and interpretability of the study findings. Additionally, more structured descriptions of Clinical data collection are warranted. It would be helpful to specify how many categories of clinical data were collected (e.g., demographic, biochemical, echocardiographic, electrocardiographic), which variables were included in each, and at what time points they were assessed (e.g., at admission, post-intervention, at discharge). Second, while the authors correctly note that single-vessel disease predominates among young AMI patients and present the distribution of culprit vessels, the severity and characteristics of the lesions remain insufficiently detailed. Specifically, the lack of ACC/AHA lesion classification and TIMI flow grading limits the angiographic assessment. These indices are clinically relevant for guiding intervention strategy and risk stratification and would add valuable context to the findings. Third, although the study aims to explore the presentation, risk factors, angiographic findings, and management of young AMI patients, it is noteworthy that clinical symptoms at presentation are not detailed. Given the clinical importance of symptom characterization for early recognition and diagnosis, including this information would help clinicians recognize such cases more effectively. Regarding the management domain, further elaboration on pharmacological therapy, particularly the use of beta-blockers, statins, and antiplatelet agents, would enhance the clinical relevance of the study. It also raises the question of whether young AMI patients tend to present with higher heart rates, and if so, whether adequate heart rate control was achieved during hospitalization or at discharge. As heart rate plays a crucial role in the progression and prognosis of coronary artery disease, such information would provide valuable insight into the effectiveness of secondary prevention strategies in this specific population. Finally, we appreciate the authors’ observation that obesity, hyperlipidemia, and smoking are prominent in young AMI patients. However, to strengthen this conclusion, we encourage the authors to consider a prospective cohort study design with multivariable adjustment, which could formally assess whether these are independent risk factors for early-onset AMI. Such analysis would increase the translational value of their findings and potentially guide targeted prevention strategies in this unique population. In conclusion, this study brings attention to a clinically important and under-explored population. We hope that the authors will consider these suggestions to further refine their methodological and clinical insights in future work. References 1. Ahmed Hegazi Abdelsamie HOA, Ahmed Taha Abdelwahed. Acute myocardial infarction in the young: A 3-year retrospective study. World Journal of Cardiology 2025;17(6) doi: 10.4330/wjc.v17.i6.106445 2. Aggarwal A, Srivastava S, Velmurugan M. Newer perspectives of coronary artery disease in young. World J Cardiol 2016;8(12):728-34. doi: 10.4330/wjc.v8.i12.728 "  [Collapse]
Hegazi Abdelsamie A, Abdelhadi HO, Abdelwahed AT. Acute myocardial infarction in the young: A 3-year retrospective study. World J Cardiol 2025; 17(6): 106445
14
"The manuscript by Camille Kass and co-authors focuses on the issue of eating disorders following bariatric surgery that may be ..."  [Read more]
"The manuscript by Camille Kass and co-authors focuses on the issue of eating disorders following bariatric surgery that may be associated with physical and physiological changes, as well as various psychological phenomena related to the effects of the surgery and dietary modifications. Diagnosis and treatment of these disorders require appropriate categorization within disease classification systems, particularly the DSM-5. However, creating such a classification with the inclusion of new categories in the existing list or expanding the diagnostic criteria requires a requires the accumulation of a sufficiently large database. The presented article describes a case of eating disorder after bariatric surgery with a detailed description of symptoms and their dynamics in the course of complex therapy. Based on the data obtained and the results of literature analysis, the authors conclude that the observed disorder is the closest to avoidant/restrictive food intake disorder according to DSM-5. At the same time, the results of the patient's follow-up confirm the opinions expressed by other authors about the need to include body dysmorphia, and the loss of personal identity associated with severe weight loss, in the diagnostic criteria for ARFID. The presented article has some relevance for the development of a diagnostic system for eating disorders. However, it should be noted that the authors did not practically consider the possible influence of the patient's premorbid background (generalized anxiety disorder) and its interaction with the effects of bariatric surgery on the observed eating disorders. In general, it seems reasonable and interesting to conduct such an analysis using author’s own results and data from the literature. "  [Collapse]
Cass K, Leggett A, Gibson DG. Diagnostic dilemma of avoidant/restrictive food intake disorder after bariatric surgery: A case report and review of literature. World J Clin Cases 2025; 13(24): 106941
15
"This article is a study on the development and validation of a visceral adipose tissue (VAT)-based delta radiomics model to predict ..."  [Read more]
"This article is a study on the development and validation of a visceral adipose tissue (VAT)-based delta radiomics model to predict secondary loss of response to infliximab therapy in patients with Crohn’s disease. Both VAT and mesenteric adipose tissue are types of fat tissue that influence the pathogenesis and treatment outcomes in Crohn’s disease, but each has distinct characteristics. VAT refers to a broad range of adipose tissue and affects systemic inflammation and treatment outcomes. In contrast, mesenteric adipose tissue is specifically located around the intestines and is deeply involved in local inflammation and the progression of intestinal pathology. Although mesenteric adipose tissue is considered a part of VAT, its specific role in Crohn’s disease has attracted particular attention. Abnormal proliferation of mesenteric adipose tissue has been suggested to contribute to complex conditions, including intestinal fibrosis, strictures, and perforation. In the future, further investigation into the relationship between VAT and mesenteric adipose tissue is warranted. "  [Collapse]
Li X, Song FL, He HF, Zeng SM, Feng ZC, Rong PF. Longitudinal computed tomography-based delta-radiomics of visceral adipose tissue predicts infliximab secondary loss of response in Crohn’s disease patients. World J Gastroenterol 2025; 31(21): 105895
16
"Commentary on articles published in World Journal of Gastroenterology Reader Perspective Prof. Zeinab Nabil Ahmed Said Reader’s code: ..."  [Read more]
"Commentary on articles published in World Journal of Gastroenterology Reader Perspective Prof. Zeinab Nabil Ahmed Said Reader’s code: 02441096) Prevalence and risk factors of Helicobacter pylori infection in Xinjiang Uygur Autonomous Region: A cross-sectional study of all age groups Jiang Q, Liu WD, Hui WJ, Kong WJ, Feng Y, Kuerbanjiang A, Huang XL, Gao F. Prevalence and risk factors of Helicobacter pylori infection in Xinjiang Uygur Autonomous Region: A cross-sectional study of all age groups. World J Gastroenterol 2025; 31(21): 106033 [PMID: 40538506 DOI: 10.3748/wjg.v31.i21.106033] The study is a cross sectional prevalence study to evaluate the H. pylori infection and risk factors in one of the large province in China that located in the northwest of the country with multiethnic aggregation. Such studies pave the way for policy makers for effective implementation of prevention and control strategies. The study involves 15 regions with 18951708 population. A total of 4665 people were surveyed, with questionnaire surveys and H. pylori antibody blood tests were conducted. 4361 were tested for H. pylori antibody. Social, economic factors, public health conditions, as well as dietary and living habits among different areas were evaluated to identify risk factors associated with H. pylori prevalence in different regions. Methodology: The reason for having blood samples in the morning on an empty stomach is not clarified. Also, the type of tested Ig must be mentioned. IgG is denoting previous exposure not current infection. Active infection is detected by urea breath tests and stool antigen tests. Results:  It is better to say overall H pylori prevalence rather than infection.  Tables: Significant p value is better to be marked, by *for example. Discussion: This section is well organized and theoretical analysis of data is well presented, however, to avoid the limitation of some missing data, sensitivity analysis is better to be done. "  [Collapse]
Zhang Y, Tang YW, Zhou J, Wei YR, Peng YT, Yan Z, Yue ZH. Electroacupuncture at ST36 ameliorates gastric dysmotility in rats with diabetic gastroparesis via the nucleus tractus solitarius-vagal axis. World J Gastroenterol 2025; 31(21): 107395
17
"Dear Editor, Thank you for inviting me to review the manuscript entitled "Efficacy Comparison of Intravenous Proton Pump Inhibitors ..."  [Read more]
"Dear Editor, Thank you for inviting me to review the manuscript entitled "Efficacy Comparison of Intravenous Proton Pump Inhibitors versus Oral Potassium-Competitive Acid Blockers Before Endoscopic Therapy for Bleeding Peptic Ulcers." Upon review, I am particularly impressed by the study's advancements and strengths in the following areas: Focused and Clinically Relevant Topic: This study directly addresses a critical question in gastroenterological practice: optimizing the management strategy for acute upper gastrointestinal bleeding before endoscopic intervention. Comparing the widely used intravenous PPIs with the emerging oral PCABs renders the topic highly timely and of significant clinical value, providing valuable evidence to inform optimal treatment decisions. Clinically Aligned Study Design: The authors employed a retrospective single-center design, effectively capturing the real-world scenario where physicians select medication (PPI or PCAB) based on individual patient circumstances. Such research based on real-world data yields results with greater direct relevance for guiding routine clinical practice. Sophisticated Statistical Methodology: Recognizing the potential for confounding inherent in retrospective observational studies, the authors proactively applied Propensity Score Matching (PSM), an advanced statistical technique, to mitigate potential confounders and balance inter-group differences. This demonstrates the authors' commitment to methodological rigor and enhancing the reliability of the findings. Focus on Core Clinical Outcomes: Selecting rebleeding rate as a primary endpoint is a key strength. This is a robust indicator directly reflecting treatment efficacy and patient safety. Focusing on this core outcome ensures the results possess clear clinical relevance and directly serve the fundamental goal of improving patient prognosis. Introduction of an Innovative Concept: The proposed "Green Endoscopy" hypothesis – suggesting oral PCABs might reduce waste associated with intravenous drug administration – represents a highly forward-thinking and innovative perspective. This reflects the authors' attention not only to efficacy but also to the sustainability and environmental impact of medical practice, thereby broadening the dimensions of treatment strategy evaluation and opening a valuable new direction for future research. Clear Data Presentation and Defined Core Findings: The core methodology and results sections are presented clearly, enabling readers to grasp the study's framework and principal findings. Particularly noteworthy is the preliminary indication of comparable efficacy between intravenous PPIs and oral PCABs on key observational metrics, which in itself provides valuable information for clinical practice. Overall Readability: The manuscript is generally well-written and fluent, effectively communicating the main content and intent of the research, ensuring the efficient transmission of scientific information. Summary: Scientific Quality: Grade B Language Quality: Grade B Recommendation: Meets publication standards "  [Collapse]
Lim NR, Chung WC. Intravenous proton pump inhibitors vs oral potassium competitive acid blockers before endoscopic treatment of bleeding peptic ulcers. World J Gastrointest Endosc 2025; 17(6): 104234
18
"The retrospective study on Comparison of treatment strategies for submucosal tumors originating from the muscularis propria at ..."  [Read more]
"The retrospective study on Comparison of treatment strategies for submucosal tumors originating from the muscularis propria at esophagogastric junction or cardia by Lee AY, Lim SG, Cho JY, Kim S, Lee KM, Shin SJ, Noh CK, Lee GH, Hur H, Han SU, Son SY, Song JH is well conducted and written.  It very nicely describes the three techniques ESD, STER and LSW for lesions of the esophagus with excellent illustrations of all the three techniques with figures. It paves the path for feasibility of further studies will large number of sample size. "  [Collapse]
Lee AY, Lim SG, Cho JY, Kim S, Lee KM, Shin SJ, Noh CK, Lee GH, Hur H, Han SU, Son SY, Song JH. Comparison of treatment strategies for submucosal tumors originating from the muscularis propria at esophagogastric junction or cardia. World J Gastroenterol 2025; 31(23): 106261
19
"This paper provides a systematic review of artificial intelligence (AI) models in the diagnosis of irritable bowel syndrome (IBS), ..."  [Read more]
"This paper provides a systematic review of artificial intelligence (AI) models in the diagnosis of irritable bowel syndrome (IBS), highlighting the potential of AI to improve diagnostic accuracy using complex biomarkers such as the fecal microbiome, gas chromatography, neuroimaging, and protease activity. The review comprehensively summarizes the performance of AI models across various studies, showing promising diagnostic accuracy, particularly in models using fecal microbiome analysis. The findings are clinically relevant, as AI has the potential to overcome the limitations of current symptom-based diagnostic frameworks like the Rome IV criteria, offering a more objective and precise approach to IBS diagnosis. "  [Collapse]
Bhagavathula AS, Al Qady AM, Aldhaleei WA. Diagnostic accuracy and quality of artificial intelligence models in irritable bowel syndrome: A systematic review. World J Gastroenterol 2025; 31(23): 106836
20
"This paper provides a timely and insightful review on the application of machine learning (ML) in diagnosing and treating esophageal ..."  [Read more]
"This paper provides a timely and insightful review on the application of machine learning (ML) in diagnosing and treating esophageal disorders, including conditions like GERD, esophageal cancer, and achalasia. The study highlights the potential of AI in enhancing diagnostic accuracy and personalizing treatment strategies, which could greatly improve patient outcomes in gastroenterology. The comprehensive synthesis of current literature and the focus on ML’s role in automating diagnosis and optimizing treatment are highly relevant for clinical practice. The manuscript offers significant value by showing how ML can transform the management of esophageal diseases and improve patient care. "  [Collapse]
Liu SW, Li P, Li XQ, Wang Q, Duan JY, Chen J, Li RH, Guo YF. Recent advances in machine learning for precision diagnosis and treatment of esophageal disorders. World J Gastroenterol 2025; 31(23): 105076
995 items  Read more >>
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