Baishideng Publishing Group

Zhang XL, Hong QQ, Huang YQ. Influence of enhanced recovery after surgery protocol on first exhaust time after laparoscopic resection of colorectal cancer. World J Gastrointest Surg 2026; 18(3): 116149

"Dear Editorial team Baishideng Publishing Group. World Journal of Gastroenterology Im honored to contribute with the high quality ..." [Read more]

"Dear Editorial team Baishideng Publishing Group. World Journal of Gastroenterology Im honored to contribute with the high quality journals published by Baishideng Publishing Group BPG, in particular with World Journal of Gastroenterology WJG. Im completely satistified with the entire peer review and editorial proccess of publication. Thank you very much to the entire team for the support during the editorial proccess. Best regards from Chile. " [Collapse]

Lindner C. Letter to the Editor: AADN score predicts overall and progression-free survival in triple therapy for hepatocellular carcinoma. World J Gastroenterol 2026; 32(13): 116481

"Thanks for the great efforts of the editors and reviewers in addressing our manuscript. We are satisfied with the manuscript editing ..." [Read more]

"Thanks for the great efforts of the editors and reviewers in addressing our manuscript. We are satisfied with the manuscript editing and publishing process. We are also satisfied with the peer review process. We hope our study can be helpful in providing information for future research. We greatly appreciate the time and effort you and the editorial team have dedicated to guiding our paper through the review and publication process. Your thoughtful feedback and support have been invaluable, and we are grateful for the opportunity to contribute to your esteemed journal. " [Collapse]

Zhang Y, Wang S, Hei MY. Attenuating neuropsychiatric disorders of early-life stress: The protective role of oxytocin. World J Psychiatry 2026; 16(4): 115109

"We sincerely thank the editorial office of the journal for their highly efficient, professional and rigorous handling throughout the ..." [Read more]

"We sincerely thank the editorial office of the journal for their highly efficient, professional and rigorous handling throughout the review and publication process, as well as their strict adherence to high academic and editorial standards. We are also truly grateful to the anonymous peer reviewers for their thoughtful, meticulous and expert feedback. Their constructive comments and valuable suggestions have greatly improved the academic depth, logical structure and overall presentation of our published paper. " [Collapse]

Liu N, Zhang M, Guo Y, Bian J, Meng XK, Li J. Application of T-tube stent external drainage for the prevention of postoperative biliary stricture during choledochojejunostomy. World J Gastrointest Surg 2026; 18(3): 115888

"We appreciate the journal's transparent handling process and timely editorial feedback, which reinforced our trust in its academic ..." [Read more]

"We appreciate the journal's transparent handling process and timely editorial feedback, which reinforced our trust in its academic integrity. The peer review was rigorous and constructive, with reviewers providing insightful comments that substantially improved our manuscript. The process was fair and professional. Suggestion: More consistent review return times would help authors better plan revisions. Overall, we hold a positive view of this journal and would submit again. " [Collapse]

Wang MR, Zheng LF, Yang F, Gu XY, Yang JS, Chen FX, Liu JM, He BS. Development and validation of prognostic models for colon cancer incorporating extramural vascular invasion assessed by contrast-enhanced computed tomography. World J Gastroenterol 2026; 32(14): 116415

"We found the overall process remarkably smooth and handled with impressive promptness. We particularly appreciate the seamless ..." [Read more]

"We found the overall process remarkably smooth and handled with impressive promptness. We particularly appreciate the seamless automation and the insightful, constructive feedback provided by the referees and editors. Furthermore, the post-review stage, including final manuscript editing and production, was handled with exceptional speed and professional efficiency throughout. Thank you " [Collapse]

Sharma K, Jindal N, Sharma M, Mandavdhare HS, Gupta P, Sekar A, Dutta U, Sharma V. Xpert Ultra and TrueNat MTB plus assays for the diagnosis of gastrointestinal tuberculosis: A diagnostic accuracy study. World J Gastroenterol 2026; 32(14): 116088

"Your journal’s publishing services have left me thoroughly satisfied in every relevant aspect. The online full-text submission forms ..." [Read more]

"Your journal’s publishing services have left me thoroughly satisfied in every relevant aspect. The online full-text submission forms are thoughtfully designed and simple to navigate, streamlining the preparation process. The article publication process is smooth and well-managed, with each step carried out efficiently and without confusion. I appreciate the clear and practical academic rules and standards provided, which have been instrumental in guiding my manuscript preparation. The academic misconduct detection report is reliable and thorough, the publication period is reasonable and consistent with academic norms, and the editing and publishing standards are rigorous and professional. The time allocated for peer review is sufficient to ensure a careful evaluation, the anonymous peer review process is fair and standardized, and the peer review report has been extremely helpful for my manuscript, featuring fair and objective assessments throughout. " [Collapse]

Gao H, Yin DF, Xing XR, Zhou LJ, Yu R. MiR-200a-3p/ZEB1/IRF1-mediated PANoptosis prompts Xiangshaliujunzi decoction to overcome 5-fluorouracil resistance in gastric cancer. World J Gastroenterol 2026; 32(14): 114331

"Nothing to add. The procedure was perfect. The only thing I have to mention is that the time passed from the completion of acceptance ..." [Read more]

"Nothing to add. The procedure was perfect. The only thing I have to mention is that the time passed from the completion of acceptance till the publication was too long. Nevertheless, the review ers' comments were very helpful and the communication with the editorial desk was absolutely perfect. Would journal of Gastroenterology is an excellent journal and I am going to submit more studies of mine in the future. Thank you " [Collapse]

Karagiannakis DS. Letter to the Editor: Does hepatectomy outweigh radiofrequency ablation in the management of small hepatocellular carcinoma? World J Gastroenterol 2026; 32(12): 116380

"The review process is very rigorous but is very fast. By this rigorous review process the manuscript will improve so much. Figures ..." [Read more]

"The review process is very rigorous but is very fast. By this rigorous review process the manuscript will improve so much. Figures and tables are also adjusted in the pdf well and quality is very fine. I am very impressed with the rigorous review process of this journal but the timeline to review the manuscript is also very fast. " [Collapse]

Bharadwaj A, Taneja M, Dubey S, Saxena A. Very low-density lipoprotein and the human health. World J Exp Med 2026; 16(1): 117024

"We appreciate the opportunity to publish our work in this journal. The editorial and peer-review process was rigorous, constructive, ..." [Read more]

"We appreciate the opportunity to publish our work in this journal. The editorial and peer-review process was rigorous, constructive, and efficient, which significantly improved the quality and clarity of our manuscript. The journal maintains high academic standards and provides valuable guidance to authors throughout the submission and revision stages. We are particularly impressed by the professionalism of the editorial team and the timely communication at each step. Overall, this has been a positive publishing experience, and we look forward to contributing to the journal again in the future. " [Collapse]

Li YX, Guo LJ. Residual anorectal malignant melanoma presenting as polyp-like lesion detected during colonoscopic withdrawal observation: A case report and review of literature. World J Clin Cases 2026; 14(10): 119456

"Dear Editor, I would like to express my sincere gratitude to the editorial team of the World Journal of Clinical Cases for the ..." [Read more]

"Dear Editor, I would like to express my sincere gratitude to the editorial team of the World Journal of Clinical Cases for the successful publication of my manuscript. I truly appreciate the guidance and support provided throughout the review and publication process. It has been a valuable experience for me, and I am honored to have my work featured in your esteemed journal. I hope that my article contributes meaningfully to the existing literature and assists clinicians and researchers in their practice and future studies. Thank you once again for your support and professionalism. Warm regards, Dr. Olando Kevin Dsouza " [Collapse]

D’Souza OK. Comparative evaluation of anesthetic efficacy of articaine vs lignocaine during root canal therapy in hypomineralized second primary molars. World J Clin Cases 2026; 14(10): 118053

"We thank the reviewers and editorial team for their comments which greatly enhanced the quality and content of our manuscript. Not ..." [Read more]

"We thank the reviewers and editorial team for their comments which greatly enhanced the quality and content of our manuscript. Not only did the reviewers provide constructive feedback, they also encouraged us to add a literature review to our case report to make it more enriching to read. We are also thankful for the editing service and publication management. " [Collapse]

Raj A, Nishant P, Kumar R, Sharma A, Singh P, Patra PK, Sinha S. Blau syndrome at a tertiary care center of Eastern India: Two case reports and review of literature. World J Clin Cases 2026; 14(10): 118630

"Thank you so much, dear teachers and experts, for your kind help! I've gained a great deal during the process of getting my article ..." [Read more]

"Thank you so much, dear teachers and experts, for your kind help! I've gained a great deal during the process of getting my article published. I'm especially grateful for the high - quality guidance from my fellow teachers and the painstaking feedback on the article's layout from the editorial teachers. " [Collapse]

Li HL. Bipolar disorder with multiple comorbidities of a 55-year-old female patient: A case report. World J Clin Cases 2026; 14(10): 118579

"Editorial office communication was excellent from the first submission through publication, and the review process and reviewers' ..." [Read more]

"Editorial office communication was excellent from the first submission through publication, and the review process and reviewers' comments were outstanding, helping improve the article's quality. Editorial team e-mail responses were very quick. Editing quality, reviewers' quality inputs were excellent. Closed and reminding deadlines were always helpful in preventing procrastination. Overall experience was very good. " [Collapse]

A R A, Kannekanti P. Emerging need for addressing trauma and enhancing psychosocial support among witch-hunt survivors in India. World J Psychiatry 2026; 16(4): 110197

"We are quite satisfied with the publication process-efficient handling, clear communication, timely peer review, and professional ..." [Read more]

"We are quite satisfied with the publication process-efficient handling, clear communication, timely peer review, and professional support throughout. A smooth and rewarding experience. The editorial team was rigorous yet timely, and publication was well-coordinated. From submission to final publication, everything was handled professionally, efficiently, and with great care. Thank you for your hard work. " [Collapse]

Jing P, Liu XC, Yin XP, Fu Y, Tian Q, Zhang XB. Progress on the neurotrophic effects of antidepressant drugs. World J Psychiatry 2026; 16(4): 115300

"We are quite satisfied with the PDF produced by your journal and the speed of your review process. However, the publication cost of ..." [Read more]

"We are quite satisfied with the PDF produced by your journal and the speed of your review process. However, the publication cost of your journal is too expensive to bear. I hope your publication can reduce its publication costs.The layout fee is too expensive, and we may not consider your publication in the future.There's nothing else left.There's nothing else left. " [Collapse]

Cai SY, Gu HL, Zhao LH, Chen H. Health ecology-based nursing impact on stigma, anxiety, and depression in young and middle-aged type 2 diabetes patients. World J Psychiatry 2026; 16(4): 115233

"I hold a strong sense of satisfaction with all aspects of your journal’s publishing services. The forms for online full-text submission ..." [Read more]

"I hold a strong sense of satisfaction with all aspects of your journal’s publishing services. The forms for online full-text submission are well-prepared and straightforward, making the initial submission process trouble-free. The article publication process is well-coordinated and efficient, with clear communication at each stage. I am also satisfied with the detailed academic rules and standards provided, which have effectively guided me in perfecting my manuscript. The academic misconduct detection report is credible and comprehensive, the publication period is well-planned and reasonable, and the editing and publishing rules are strict and professional. The peer review duration is appropriate for in-depth assessment, the anonymous peer review process is conducted impartially, and the peer review report has offered great help for my manuscript, with completely fair and objective comments. " [Collapse]

Liu X, Zhao J, Wang YX, Pei YJ, Shi XP, Peng SW. Effect of combined pulmonary-psychological nursing on posttraumatic stress disorder in patients with acute respiratory distress syndrome. World J Psychiatry 2026; 16(4): 114419

"I would like to express my sincere appreciation for the editorial team and the reviewers involved in handling my manuscript. The entire ..." [Read more]

"I would like to express my sincere appreciation for the editorial team and the reviewers involved in handling my manuscript. The entire review process was conducted in a professional, efficient, and well-organized manner.The reviewers provided thoughtful, constructive, and highly insightful comments that significantly improved the quality of our work. Their feedback was detailed and focused on both scientific rigor and clarity, which we found extremely valuable.The editorial handling was prompt and transparent. The communication from the editorial office was clear and timely at each stage, from submission to final decision. Despite the complexity of the review process, the total time from submission to acceptance was approximately 150 days, which is reasonable and well within the expected timeline for a rigorous peer-review process. " [Collapse]

Tang J, Ding SL, Wu Y, Wu YP, Yuan XB, Wu PF, Sha DS. Prognostic value of a nomogram model for pancreatic cancer incorporating the systemic immune-inflammation and prognostic nutritional indices. World J Gastrointest Surg 2026; 18(3): 115906

"We sincerely thank the editor and reviewers for their valuable comments, which have significantly improved the quality of our ..." [Read more]

"We sincerely thank the editor and reviewers for their valuable comments, which have significantly improved the quality of our manuscript. Through additional experiments and thorough revisions, we have addressed all concerns and strengthened the mechanistic insights and translational relevance of our study. We believe the revised manuscript is now significantly improved and suitable for publication in your esteemed journal. " [Collapse]

Hong SC, Du YY, Wang GB, Wang SQ, Zheng YF, Wang N, Situ HL, Wang ZY. Chinese herbal formulas alleviated depression in breast cancer patients: A meta-analysis, network pharmacology and experimental validation. World J Psychiatry 2026; 16(4): 115981

"I’m truly satisfied with everything about this work—the process, the unexpected turns, and the final result. Writing it felt like ..." [Read more]

"I’m truly satisfied with everything about this work—the process, the unexpected turns, and the final result. Writing it felt like a journey where every challenge turned into a gift. I hope readers can feel that same sense of contentment and see how each element found its place. Thank you for joining me on this page. " [Collapse]

Xu K, Zhou DH, Liu JS, Feng J. Impact of indomethacin combined with pancreatic duct stent placement on high-risk populations of pancreatitis after endoscopic retrograde cholangiopancreatography. World J Gastrointest Surg 2026; 18(3): 115383

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Article Quality Tracking-Peer-Review

"It has been stated that PPI s alone are good effective for aspirin induced gastrointestinal bleeding, but not sufficiently effective ..." [Read more]

"It has been stated that PPI s alone are good effective for aspirin induced gastrointestinal bleeding, but not sufficiently effective for clopidogrel induced gastrointestinal bleeding. However,co-administration with rebamipide provides sufficient hemostatic effect. Please comment the reason why pPI with rebamipide is good effect for the gastrointestinal bleeding with clopidogrel. Please comment the side effect of long term with pPI use." [Collapse]

Kim M, Chi SA, Kim JE, Kim ER, Hong SN, Kim YH, Kim K, Chang DK. Optimal strategies for mitigating gastrointestinal bleeding in patients receiving antiplatelet therapy: Real-world study. World J Gastroenterol 2026; 32(14): 115790

"The article explains very well the relevance of the Boruta variables in the clinical-endoscopic model for AIG-associated G-NETs and ..." [Read more]

"The article explains very well the relevance of the Boruta variables in the clinical-endoscopic model for AIG-associated G-NETs and clearly highlights its strengths and limitations. The text structure is good, and the logical presentation of information facilitates the understanding of the process and the mechanisms involved. In addition, the text is grammatically correct, managing to present new perspectives on how feature selection and the integration of clinical and endoscopic biomarkers can contribute to risk stratification and personalized management of patients with AIG. This approach makes a clear contribution to the specialized literature, opening avenues for future research and practical application of predictive models. " [Collapse]

Yu QQ. Risk stratification of gastric neuroendocrine tumors in autoimmune gastritis: Evaluating the clinical value of an integrated clinical-endoscopic model. World J Gastroenterol 2026; 32(13): 115440

"This is a well-written and presented a rare case report on Splenic tuberculous mass following anti-tuberculosis therapy was ..." [Read more]

"This is a well-written and presented a rare case report on Splenic tuberculous mass following anti-tuberculosis therapy was misdiagnosed as a splenic tumor. Careful questioning of a patient's medical history is crucial for avoiding misdiagnosis and inappropriate treatment. In this case, the failure to carefully question the patient's medical history at the outset is a deficiency. I think that this manuscript is suitable and worth to be published in World Journal of Gastrointestinal Surgery. " [Collapse]

Li ZK, Zhang K, Zhang HL, Lv XL, Guo JQ, Tan W. Splenic tuberculous mass following anti-tuberculosis therapy was misdiagnosed as a splenic tumor: A case report. World J Gastrointest Surg 2026; 18(3): 115137

" The article meets basic ethical standards with reported approval, though fuller disclosure of consent procedures would enhance ..." [Read more]

" The article meets basic ethical standards with reported approval, though fuller disclosure of consent procedures would enhance transparency. The methodology is appropriate and largely reproducible, but lacks some detail on controls and implementation, limiting full replication. Results are logically presented and consistent with the study design, providing partial support for the hypothesis, though broader generalizability is constrained. Figures and tables are relevant but occasionally insufficiently annotated, reducing clarity. Biostatistical analysis is acceptable, yet could be strengthened through more comprehensive reporting of effect sizes and confidence intervals. References are generally current and relevant, although inclusion of additional recent key studies would improve scholarly depth. The language is clear and mostly concise, with minor grammatical issues. Key limitations include a relatively small and possibly non-representative sample, potential bias, and inadequate discussion of confounding factors, all of which may affect the strength and applicability of the conclusions. " [Collapse]

Chen X, Zhang LL, Zhou Y, Dong DX, Qian XY. Mitochondrial autophagy in diabetes-related cognitive decline and skin ulcers: Mechanistic insights and therapeutic implications. World J Diabetes 2026; 17(3): 112177

"This is a single-center, double-blind, randomized, placebo-controlled trial that enrolled a sufficient number of patients who met ..." [Read more]

"This is a single-center, double-blind, randomized, placebo-controlled trial that enrolled a sufficient number of patients who met the Rome IV diagnostic criteria for FD. Patients were randomized to receive LPZ (30 mg once daily) in combination with FM (flupenthixol 0.5 mg + melitracen 10 mg) or a matching placebo for 2 weeks, followed by a 4-week follow-up. At week 2, the clinical response rate was higher in the LPZ + FM group than in the placebo group. The LPZ + FM group showed greater reductions in PDS, SF-NDI, PHQ-9, Generalized Anxiety Disorders-7, and Pittsburgh Sleep Quality Index scores, with improvements maintained throughout the follow-up. The first comment concerns the usefulness of such studies. These studies are very useful in daily clinical practice precisely because of the magnitude of the problem worldwide. The second comment concerns the study design. In my opinion, another pure group could be included that would receive only the FM combination. The results could separate the percentage contribution of each regimen to the final clinical outcome. In any case, as the authors note, multicenter studies are required to demonstrate the effectiveness of a combination of pharmaceutical agents for the treatment of this frequent and condition with significant functional consequences." [Collapse]

Wang XY, Yin KH, Cheng L, Wang XY, Qiao Y, Tang XR, Wang B, Yan XJ, Chen SL. Efficacy and safety of lansoprazole combined with flupentixol-melitracen for functional dyspepsia: A randomized, double-blinded, placebo-controlled clinical trial. World J Gastroenterol 2026; 32(13): 117115

"This is a compelling topic with significant clinical relevance. The development of this system stems from a key gap: while ..." [Read more]

"This is a compelling topic with significant clinical relevance. The development of this system stems from a key gap: while guidelines for several incidental findings already exist, consistent and integrated recommendations within radiology reports are lacking. The objectives of this proposal were clearly presented and well defined. The aims were to standardize terminology and decision-making for incidental findings while ensuring a transparent and reproducible link between the findings and their corresponding recommendations. Furthermore, the Incidental-Reporting and Data System (I-RADS) seeks to facilitate data collection and establish an infrastructure for artificial intelligence algorithms to learn from clearly labeled, standardized datasets—enabling machine learning, registries, and big-data research in ways that current fragmented guidelines cannot. Additionally, I-RADS can be integrated into structured reporting platforms, thereby streamlining the diagnostic workflow. I-RADS is not intended to replace existing guidance on incidental findings, such as the ACR recommendations, but rather to complement and consolidate them into a single, simplified cross-sectional system. The proposed I-RADS system features a conceptual framework designed to provide a unified and simplified approach to the classification and communication of incidental findings across imaging modalities and anatomical regions. The reviewer acknowledged that the proposal for the Incidental-Reporting and Data System represents an innovative effort with positive implications. However, unlike other systems, I-RADS must account for a wide range of miscellaneous conditions—such as aortic dissection, occult or chronic splenic rupture, thrombus in the left atrium or main pulmonary artery, retained foreign bodies, and displacement of iatrogenic grafts—which, while not malignant, are life-threatening or hazardous. These should be carefully considered. The methodology for the development of I-RADS requires revision, and the efficacy of the system needs to be validated." [Collapse]

Arkoudis NA, Moschovaki-Zeiger O, Koutserimpas C, Lama N, Velonakis G, Filippiadis D, Spiliopoulos S, Kelekis N. Proposing Incidental-Reporting and Data System: A classification system for incidental findings in radiology. World J Radiol 2026; 18(3): 119025

"TIPS is good procedure for esophageal varix. This procedure is portal vein -hepatic vein shunt. TIPS decrease portal pressure and ..." [Read more]

"TIPS is good procedure for esophageal varix. This procedure is portal vein -hepatic vein shunt. TIPS decrease portal pressure and causes highout for heart. Some patient after TIPS suffer from Eck and heart failure. Please comment about the diameter of TIPS and preoperative heart. What kinds of parameter for heart is suitable parameter for heart failure after TIPs? " [Collapse]

Zhang TQ, Zhang L, Yong X, Tian C, Chen BJ, Qin JP, Mu D, Tang SH. Transjugular intrahepatic portosystemic shunt for variceal bleeding due to hereditary hemorrhagic telangiectasia with cirrhosis: A case report. World J Gastroenterol 2026; 32(12): 119002

" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..." [Read more]

" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied" [Collapse]

Siyal M, Tahseen MU, Asim M, Niaz TS, Zakaria N, Leghari A, Niaz SK. Slipped and caught in the cecum: Endoscopic retrieval of a migrated foley feeding jejunostomy tube: A case report. World J Clin Cases 2026; 14(8): 118316

"Researchers have concluded that elastography can provide an objective assessment of esophageal varices and may serve as a non-invasive ..." [Read more]

"Researchers have concluded that elastography can provide an objective assessment of esophageal varices and may serve as a non-invasive screening tool for diagnosis and treatment indication. While abdominal ultrasound follow-up is recommended for patients with chronic liver disease, ultrasound elastography may allow for more appropriate screening of patients requiring esophageal varices via endoscopy. This is expected to reduce the need for upper gastrointestinal endoscopy, which is an uncomfortable procedure for patients, and enable more efficient medical care. Further large-scale prospective studies are needed to further validate the usefulness of this non-invasive assessment " [Collapse]

Martínez-Díaz FM, Jiménez-Cuevas EA, Morales-Galicia AE, Ramírez-Mejía MM, Qi XS, Poo JL, Méndez-Sánchez N. Toward noninvasive prediction of treatment outcomes in patients with variceal bleeding. World J Gastroenterol 2026; 32(11): 115723

"It has long been established that respiratory and digestive diseases coexist in a proportion of patients. This coexistence shares ..." [Read more]

"It has long been established that respiratory and digestive diseases coexist in a proportion of patients. This coexistence shares significant pathogenetic mechanisms, including microbial, immunological, and metabolic pathways. The combined clinical manifestations of two different systems often require complex therapeutic interventions. Thus, in recent years, the lung-gut axis has emerged as equally important, underscoring the complex bidirectional regulatory network between gastrointestinal and respiratory diseases. The clinical coexistence of digestive and respiratory system diseases in the same patient poses both diagnostic and therapeutic challenges, and their management should be rational and effective, aiming to reduce the risk of worsening the underlying diseases. The treatment of these coexisting pathological conditions requires a deep knowledge of their pathophysiology and significant experience in treating them. The need for cooperation between the gastroenterologist and the pulmonologist for the most rational treatment of patients is self-evident. This cooperation for the treatment of combined digestive diseases with diseases of other systems, in my opinion, will be increasingly required in the coming years, as the common pathogenetic mechanisms are clarified and the therapeutic quiver is enriched with new pharmaceutical agents." [Collapse]

Huang HJ, Liu PP, Dong DF. Research progress on comorbidity between gastrointestinal and pulmonary diseases from the perspective of the gut-lung axis. World J Gastroenterol 2026; 32(11): 115846

"Review summary and Recommendations 1. Clinical Context: Walled-off pancreatic necrosis (WON) is heterogeneous in clinical course. ..." [Read more]

"Review summary and Recommendations 1. Clinical Context: Walled-off pancreatic necrosis (WON) is heterogeneous in clinical course. While some patients resolve with transmural drainage alone, others deteriorate and require direct endoscopic necrosectomy (DEN). Chronological criteria, such as the 4-week cutoff in the revised Atlanta classification, do not reliably predict clinical trajectory. 2. Key Findings: o Persistent sepsis, systemic inflammatory response syndrome (SIRS), hypoalbuminemia, anemia, extensive necrosis (>30–40%), and unfavorable anatomical patterns predict drainage failure and DEN requirement. o Lone et al’s predictive model (AUC 0.892) demonstrates strong discriminative ability, supporting early identification of patients unlikely to respond to drainage alone. o The concept of “passive drainage failure” captures patients at high risk, characterized by large solid debris, compartmentalized collections, and persistent systemic inflammation. 3. Step-Up vs Upfront DEN: o Timing should not be guided solely by predefined intervals but by individualized risk assessment. o Step-up strategies minimize unnecessary interventions but may delay care in high-risk patients. o Upfront DEN can prevent deterioration in selected patients but carries higher procedural risk if overused. o Guidelines support necrosectomy in cases of persistent sepsis, cavity compartmentalization, or failure of cavity collapse despite adequate drainage. 4. Safety Considerations: o DEN is effective but carries 15–30% complication rates, including bleeding, perforation, stent occlusion, and infection exacerbation. o Deferring DEN in patients with ongoing infection or high necrotic burden may worsen outcomes and complicate later intervention. o Risk stratification is essential to balance procedural risk against the risk of inaction. 5. Future Directions: o Integration of multivariate risk models, incorporating clinical, biochemical, and imaging variables, may individualize timing decisions. o AI and machine learning could enhance predictive accuracy, using longitudinal data and quantitative necrosis assessment. o The paradigm shift is toward intervention guided by patient-specific risk rather than temporal thresholds. Recommendations 1. Clinical Practice: o Implement early risk stratification in all WON cases to identify patients at high risk of drainage failure. o Reserve step-up strategies for low-to-moderate risk patients and consider early DEN for high-risk phenotypes. o Monitor clinical, laboratory, and imaging markers closely to guide escalation decisions. 2. Research: o Validate predictive models like Lone et al’s across larger, multi-center cohorts. o Investigate AI-driven, real-time risk scoring systems integrating necrosis quantification and host response metrics. o Explore the interplay of nutritional status, necrosis morphology, and systemic inflammation as modifiers of intervention timing. 3. Guideline Implications: o Guidelines should emphasize risk-based rather than time-based criteria for DEN. o Step-up and upfront strategies should be framed as complementary, with risk stratification as the central decision-making tool. Bottom Line: Timing of DEN should transition from protocol-driven intervals to personalized, risk-guided decisions. Intervention becomes appropriate when waiting poses greater risk than acting. " [Collapse]

Singeap AM, Chiriac S, Minea H, Trifan A. Between step-up and upfront intervention: Risk stratification as the missing link in timing endoscopic necrosectomy. World J Gastrointest Endosc 2026; 18(3): 116865

"This is a high-level evaluation of a study or meta-analysis that summarizes its overall quality, reliability, strengths, limitations, ..." [Read more]

"This is a high-level evaluation of a study or meta-analysis that summarizes its overall quality, reliability, strengths, limitations, and clinical relevance without going into excessive technical detail. It’s the type of assessment a clinician, journal reviewer, or guideline committee might write to quickly judge how much weight to give the study’s findings. Overall Quality: The meta-analysis includes 17 randomized controlled trials with 1,689 patients, representing a moderate-to-high-quality evidence base. The search strategy was comprehensive, covering multiple international and Chinese databases, which minimizes publication bias. Strengths: • Large, pooled sample size with randomized controlled trial design. • Direct comparison between minimally invasive ES and standard TS. • Evaluates both efficacy and safety, including recovery time and costs. • Clinically relevant outcomes such as bleeding, prolapse, complications, and hospital stay. Limitations: • Variation in ES and TS techniques across studies may introduce heterogeneity. • Follow-up durations were not consistently reported, limiting assessment of long-term outcomes and recurrence. • Most studies had relatively small individual sample sizes, which may affect statistical power for less common complications. Clinical Relevance: • Provides strong evidence that ES is a safe, effective, and cost-efficient alternative to TS. • Supports adoption of ES as a first line minimally invasive option for internal hemorrhoid treatment, especially for patients seeking faster recovery. Conclusion: The meta-analysis is methodologically sound and clinically meaningful. While some heterogeneity exists, the findings are consistent and indicate that ES offers meaningful advantages over TS in terms of safety, recovery, and cost. Further large-scale, multicenter studies with standardized protocols would strengthen the evidence base. " [Collapse]

Wu SY, Chen YS, Li XH, Yu TJ, Xie F, Jiang QF, Lan Y, He P, Li SC, Li WS, Chen WD. Efficacy and safety of endoscopic sclerotherapy vs traditional surgery in the treatment of internal hemorrhoids: A meta-analysis. World J Gastrointest Endosc 2026; 18(3): 116697

"Summary: This study presents an exploratory analysis of bilateral upper limb sEMG activity in an experienced endoscopist during ..." [Read more]

"Summary: This study presents an exploratory analysis of bilateral upper limb sEMG activity in an experienced endoscopist during simulated colonoscopy, focusing on different bowel loop configurations. Key findings include: • Muscle activation and fatigue: Complex loops significantly increase muscle load and fatigue, particularly in the left extensor digitorum and stabilizing muscles like the left flexor carpi radialis and right middle deltoid. • Bilateral asymmetry: The left arm consistently sustains high activation, while the right arm shows task-specific activation, suggesting differential biomechanical demands for gross stabilization versus fine manipulation. • Correlation with procedure duration: Longer insertion times are associated with more rapid fatigue in stabilizer muscles. • Implications: These results objectively demonstrate increased biomechanical demand during challenging colonoscopy maneuvers, supporting the need for ergonomic interventions, workload management, and device design optimization. Strengths: • Comprehensive sEMG analysis across 14 bilateral muscles with high temporal resolution (1500 Hz). • Clear differentiation of muscle load and fatigue patterns across loop types. • Quantitative correlation between loop complexity, insertion time, and fatigue metrics. • Direct applicability to ergonomic and occupational health improvements in endoscopy. Limitations: • Single-operator study limits generalizability. • Simulation model may not fully capture anatomical variability and real-world procedural stress. • Small sample size; statistical power and inter-operator variability not addressed. Recommendations: 1. Manuscript refinement: Emphasize novelty and clinical relevance, particularly the practical applications for ergonomic device design and occupational safety protocols. 2. Future research: Recommend multi-operator studies to validate muscle activation patterns across experience levels and real-world procedures. 3. Ergonomic integration: Suggest incorporating findings into colonoscopy training programs and device evaluation to reduce repetitive strain injuries. 4. Data visualization: Consider additional heatmaps or muscle activation timelines to highlight asymmetry and fatigue progression, enhancing interpretability for clinicians. Overall Assessment: The study provides valuable, objective biomechanical data supporting ergonomic improvements in colonoscopy. With minor clarifications and broader context regarding clinical translation, this manuscript is suitable for publication in this journal focusing on endoscopy, and also journals directing occupational health, or medical ergonomics. " [Collapse]

Wang RG, Wang YQ, Cao H. Bilateral upper limb surface electromyography analysis during single-operator colonoscopy: Implications for ergonomics and occupational health. World J Gastrointest Endosc 2026; 18(3): 116646

"Summary: This retrospective cross-sectional study evaluated 801 patients with inoperable esophageal malignancies undergoing ..." [Read more]

"Summary: This retrospective cross-sectional study evaluated 801 patients with inoperable esophageal malignancies undergoing self-expandable metallic stent (SEMS) placement using the vertebral column and diaphragm as fluoroscopic landmarks. Patients ranged from 18–95 years (mean 50 ± 15), with 50.9% female. Dysphagia was the presenting symptom (mean duration 3.84 months), and squamous cell carcinoma was the predominant histology (74.16%). Tumors most commonly involved the middle third of the esophagus, and inoperability was primarily due to distant metastases (52.81%). Tracheoesophageal fistula was present in 6%, and the mean stricture length was 8.4 cm. Pre-stent dilatation was required in 17.4% of patients. SEMS lengths ranged from 8–18 cm. The landmark-based technique achieved 100% technical success without major immediate adverse events. Repeat interventions were minimal (1.87% re-stenting for tumor overgrowth; 1.37% dilatation for tumor ingrowth). Reviewer Comments: Strengths: *Large patient cohort with comprehensive demographic and tumor characteristics. *Clear demonstration of technical feasibility and safety of landmark-based SEMS placement. *Low rates of immediate complications and repeat interventions indicate procedural reliability. Limitations: *Retrospective design limits causal inference and generalizability. *Lack of comparative data with conventional SEMS placement techniques. *No formal assessment of patient-reported outcomes (e.g., dysphagia relief scores, quality of life). *Long-term stent patency and survival data are not reported. Recommendations: *Consider prospective, comparative studies to validate the landmark-based approach against standard techniques. *Include standardized patient-centered outcomes (dysphagia scoring, nutritional status, and quality of life). *Explore the applicability of this technique in anatomically complex or upper esophageal tumors. *Discussion could be strengthened by addressing limitations related to stent type, tumor morphology, and fluoroscopic variability. Overall Assessment: The study presents a practical, reproducible technique for SEMS placement using vertebral and diaphragmatic landmarks with excellent technical success. The findings are clinically relevant, particularly for high-volume centers performing palliative esophageal stenting. Future prospective studies are warranted to assess long-term outcomes and patient-centered benefits." [Collapse]

Siyal M, Asim M, Qureshi S, Ghazanfar S, Siddiqui AR, Ahmed N, Altaf A, Zakaria N, Yaseen A, Kakar F, Kadir S, Hasan MK, Niaz SK. Navigating self-expandable metallic stent placement in inoperable esophageal malignancies: A landmark-based technique using the vertebral column and diaphragm. World J Gastrointest Endosc 2026; 18(3): 116060

"This study underscores the importance of considering systemic immune modulation in H. pylori infection, particularly in DU patients, ..." [Read more]

"This study underscores the importance of considering systemic immune modulation in H. pylori infection, particularly in DU patients, and may inform future research on cytokine-mediated disease mechanisms and potential therapeutic strategies. Further, the study bridges gap between gastroenterology and systemic immunology, showing that H. pylori eradication can have meaningful systemic effects, which is clinically relevant for patient care, risk assessment, and possibly long-term outcomes. Furthermore, the findings suggest that H. pylori eradication confers systemic immunological benefits beyond the resolution of gastric pathology, including a distinct anti-inflammatory shift in duodenal ulcer patients. Incorporating disease-specific immune responses into clinical practice could support more personalized post-eradication monitoring and management. Future guidelines might consider systemic inflammation outcomes as an additional rationale for timely eradication, particularly in patients at risk for inflammation-related comorbidities." [Collapse]

de Melo FF, Lemos FFB, Leal RAOS, Rocha GA, de Magalhães Queiroz DM. Helicobacter pylori eradication is associated with systemic anti-inflammatory shift in duodenal ulcer patients compared to those with gastritis. World J Gastrointest Endosc 2026; 18(3): 116958

"Review Summary Report Review Notes: • The study addresses an important clinical question and provides practical guidance for ..." [Read more]

"Review Summary Report Review Notes: • The study addresses an important clinical question and provides practical guidance for treatment selection. • Retrospective design and relatively small sample size, especially in the stent group, limit the strength of conclusions. • Cost-effectiveness data are valuable but could be strengthened with more detailed breakdowns (e.g., procedural vs. post-procedural costs). • Future prospective studies or randomized trials could validate these findings and refine patient selection criteria for SEMS use. " [Collapse]

Yuan HF, Liu P, Guo CQ, Bi YH. Comparative study of self-expandable stent placement, bougie dilation, and balloon dilation for post-inflammatory oesophageal strictures. World J Gastrointest Endosc 2026; 18(3): 117303

"The manuscript addresses a highly relevant and timely topic in medical education. The focus on VR-based endoscopy training is ..." [Read more]

"The manuscript addresses a highly relevant and timely topic in medical education. The focus on VR-based endoscopy training is well-motivated given patient safety concerns and the growing adoption of simulation-based methods. The systematic review methodology is appropriate, and the results are clearly summarized. Overall, the manuscript is of interest to readers in gastroenterology, medical education, and simulation-based training. • Significance: Addresses a highly relevant topic in endoscopy training and patient safety; VR-based training is of growing interest. • Strengths: o Clear focus on multiple endoscopic procedures (EGD, colonoscopy, ERCP, EUS). o Adherence to PRISMA 2020 guidelines is noted. o Quantitative outcomes (odds ratios, P-values, competency scores) enhance rigor. o Balanced conclusion emphasizes VR as an adjunct to conventional training. • Major Points for Revision: o Provide detailed search strategy (databases, terms, date range) and inclusion/exclusion criteria; consider adding a PRISMA flow diagram. o Clarify study selection and screening process; report if independent reviewers were used. o Include risk-of-bias assessment for included studies using standard tools (e.g., Cochrane RoB 2, ROBINS-I). o Discuss heterogeneity across studies (simulator type, trainee experience, training duration) and its impact on results. o Address clinical relevance beyond skill metrics (e.g., patient outcomes, procedural complications, skill retention). o Standardize outcome reporting for clarity (odds ratios, mean ± SD, pass rates). • Minor Points: o Ensure consistent abbreviation usage (GIE vs GI endoscopy). o Simplify complex sentences for readability. o Include review registration information if available (e.g., PROSPERO). • Recommendation: Minor to moderate revision; manuscript is strong but would benefit from enhanced methodological transparency and discussion of heterogeneity and clinical impact. " [Collapse]

Gadour E, Miutescu B, Nica C, Taheri E, Al Saeed Z, Raheem B, Facciorusso A, AlQahtani MS. Virtual reality training for gastrointestinal endoscopy: A systematic review of efficacy and outcomes. World J Gastrointest Endosc 2026; 18(3): 117820

"Overall Assessment: This manuscript addresses a highly relevant and timely topic, evaluating the diagnostic performance of AI-assisted ..." [Read more]

"Overall Assessment: This manuscript addresses a highly relevant and timely topic, evaluating the diagnostic performance of AI-assisted colonoscopy for real-time colorectal polyp histology. The study is well-structured, with rigorous methodology and clear presentation of results. The findings, demonstrating that AI outperforms human endoscopists—particularly in less experienced operators—are clinically important. However, several aspects require clarification and elaboration to strengthen the manuscript’s impact and reproducibility. Major Comments: Search Strategy & Study Selection: Please provide full details of the literature search, including databases, search terms, date range, and inclusion/exclusion criteria. A PRISMA flow diagram would enhance transparency. Quality Assessment: Include a table summarizing QUADAS-2 risk of bias assessments for all studies. Clarify how studies with high risk of bias were considered in analyses. Heterogeneity: Substantial heterogeneity (I² = 74.3%) is reported. Consider subgroup or meta-regression analyses based on AI type, polyp characteristics, or endoscopist experience to explore sources of variability. Statistical Analysis: Clarify whether hierarchical or bivariate models were considered, as these are often preferred in diagnostic accuracy meta-analyses. Clinical Interpretation: Discuss the practical significance of AI’s improved accuracy, including potential impact on management decisions, optical biopsy strategies, and clinical workflows. Limitations: Explicitly address publication bias, spectrum bias, and generalizability of AI algorithms across centers. Also, note that AI technology is rapidly evolving, which may limit applicability of current findings. Minor Comments: Clarify the definition of “human experts” (experience, certification). *Specify polyp types included in the analysis. *Consider tables summarizing AI algorithms, training/validation datasets, and imaging modalities. *Streamline some sentences for readability and consistency in terminology. *Briefly mention future considerations such as cost-effectiveness, regulatory, and ethical implications of AI deployment. Recommendation: The manuscript is important and of high interest, but minor to moderate revisions are required to clarify methodology, address heterogeneity, and strengthen discussion of clinical applicability and limitations." [Collapse]

Curlej P, Soldera J. Artificial intelligence in predicting colorectal polyp histology: Systematic review and meta-analysis of diagnostic accuracy in real-time procedures. World J Gastrointest Endosc 2026; 18(3): 116381

"Post-ERCP pancreatitis (PEP) is comprehensive and clearly outlined both epidemiology and pathophysiology. The discussion appropriately ..." [Read more]

"Post-ERCP pancreatitis (PEP) is comprehensive and clearly outlined both epidemiology and pathophysiology. The discussion appropriately highlights the multifactorial nature of PEP and effectively integrates patient- and procedure-related risk factors. The emphasis on individualized risk assessment and evidence-based preventive strategies is well-placed. To further strengthen the manuscript for a critical audience, consider the following suggestions: 1. Clarify incidence ranges: You report an incidence of 3–15% in general populations and up to 40% in high-risk patients. Providing references for these ranges and defining “high-risk” explicitly (e.g., presence of multiple risk factors, prior pancreatitis, or sphincter of Oddi dysfunction) would enhance clarity. 2. Risk factor hierarchy: While multiple risk factors are listed, it may be helpful to indicate which factors carry the strongest evidence or highest odds ratios, perhaps in a table or figure. This helps readers quickly gauge clinical impact. 3. Preventive strategies: The paragraph mentions rectal NSAIDs, pancreatic stenting, hydration, and precut sphincterotomy. It could be strengthened by briefly noting the level of evidence or guideline recommendation for each (e.g., ESGE or ASGE guidelines), distinguishing strategies supported by strong randomized trials versus observational data. 4. Pharmacologic agents: The statement that agents like somatostatin, gabexate, and nafamostat have inconsistent efficacy is accurate, but citing meta-analyses or systematic reviews would make this more authoritative. 5. Emerging tools: Mentioning AI and risk prediction models is forward-looking. Consider briefly highlighting specific models that have shown promise or limitations, to give readers a sense of current clinical applicability. 6. Future directions: The call for standardization and validation is important. You might also suggest exploring combination preventive strategies and personalized approaches based on risk stratification, which would align with precision medicine trends. Overall, the paragraph is well-structured and readable, with a clear progression from epidemiology to pathogenesis, risk factors, prevention, and future directions. Addressing the points above would enhance rigor and utility for a specialist audience. " [Collapse]

Xu PW, Xu QQ, Yu Y, Jiao Y, Liu YH, Yang L. Risk factors and prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis. World J Gastrointest Endosc 2026; 18(3): 115736

"Clinically, the report is worthy. It clearly frames the problem, current solutions, and future directions. Cholangiocarcinoma is an ..." [Read more]

"Clinically, the report is worthy. It clearly frames the problem, current solutions, and future directions. Cholangiocarcinoma is an aggressive malignancy often diagnosed at an advanced stage due to nonspecific symptoms. Conventional imaging and ERCP-based sampling have limited sensitivity, with reported diagnostic yields of 50–70% for tissue acquisition. Digital single-operator cholangioscopy improves diagnostic accuracy to 85–95% through direct visualization and targeted biopsies and facilitates therapeutic interventions, including biliary drainage, stenting, photodynamic therapy, and radiofrequency ablation, with procedural complication rates typically <5%. Despite these advances, interobserver variability, operator expertise, and limited long-term outcome data remain challenges. Integration of artificial intelligence shows preliminary promise in real-time lesion characterization but requires prospective validation. Future studies should define comparative effectiveness, patient-centered outcomes, and standardized protocols to optimize cholangioscopy in multidisciplinary CCA management." [Collapse]

Musalia JG, Alzayyat S, Aljahdli ES, Al-Lehibi A, Lara LF, Gabr M. Cholangioscopy in the diagnosis and management of cholangiocarcinoma. World J Gastrointest Endosc 2026; 18(3): 115412

15979 items Read more >>

Peer-Reviewers and Manuscript Statistics

Editorial board members: 2263

Peer-reviewers: 36787

Manuscripts received today: 3

Manuscript reviews today: 6

Unhandled manuscripts today: 165

Active peer-reviewers today: 210

Reviewer acceptance today: 2

Reviewer refusals today: 4

Total accepted manuscripts: 40953

Total rejected manuscripts: 45176

Total peer-reviewers: 4758746

Total submissions: 38660

Baishideng Publishing Group (BPG) publishes 47 peer-reviewed, open-access journals covering a broad range of topics in clinical medicine, as well as several topics in biochemistry and molecular biology, relevant to human health today.

BPG Journal List

Reference Citation Analysis

BPG E-Books

BPG Blog

All Journal Articles

Lu QS, Ma L, Jiang WJ, Wang XB, Lu M. Correction to: KAT7/HMGN1 signaling epigenetically induces tyrosine phosphorylation-regulated kinase 1A expression to ameliorate insulin resistance in Alzheimer’s disease. World J Psychiatry 2026; 16(4): 117493

2026-04-19 | Browse: 180 | Download: 55

Wang DY, Yuan MY, Zhi H. Comorbid depression and glycemic instability in adolescent type 1 diabetes: Clinical insights into suicide risk. World J Psychiatry 2026; 16(4): 117207

2026-04-19 | Browse: 182 | Download: 73

Deng YZ, Sun J, Zhang M, Zhang XB, Yuan M, Li YF. Correlation of anxiety and depression with sleep quality and post-traumatic growth in brain tumor patients and associated determinants. World J Psychiatry 2026; 16(4): 116632

2026-04-19 | Browse: 208 | Download: 109

Zeng Y, Yang J, Kuang L. Bridging the gap between subjective and objective measures: A multimodal protocol for adolescent depression detection. World J Psychiatry 2026; 16(4): 116428

2026-04-19 | Browse: 165 | Download: 66

Liu JY, Liang ZH, Liu JL, Li L, Cui B, Li TG. Anxiety, depression, and quality of life in hepatocellular carcinoma treated with drug-eluting microspheres plus lenvatinib: A prospective study. World J Psychiatry 2026; 16(4): 116158

2026-04-19 | Browse: 195 | Download: 122

You LF, Qin J, Sun YW, Gao Q. Relationship between personality, resilience, and empathy among dental students: A cross-sectional study. World J Psychiatry 2026; 16(4): 116146

2026-04-19 | Browse: 159 | Download: 82

2026-04-19 | Browse: 185 | Download: 91

Gao LL, Huang AW, He D, Tong JZ, Hong WF, Zhuang XJ, Wu XM, Zhou YH, Lin M. Yueju pill regulates the mechanism of SIRT1/FoxO3a-mediated autophagy pathway against depression. World J Psychiatry 2026; 16(4): 115960

2026-04-19 | Browse: 184 | Download: 94

Morya AK, Morya R, Khullar S. Letter to the Editor: Interplay between ocular surface function, sleep quality, and psychological factors in dry eye disease. World J Psychiatry 2026; 16(4): 115951

2026-04-19 | Browse: 165 | Download: 75

Contreras CM, Gutiérrez-García AG. Depression and antidepressant drugs: Beyond a purely neurotransmitter approach. World J Psychiatry 2026; 16(4): 115720

2026-04-19 | Browse: 154 | Download: 77

Jie Y, Lai ZW, Zhou W, Li YC, Zhong BL, Zeng XX, Jiang Q. Neuroimmune synapse and modulation by anesthetics: Inflammatory mechanisms and therapeutic perspectives for postoperative neurocognitive disorders. World J Psychiatry 2026; 16(4): 115567

2026-04-19 | Browse: 170 | Download: 86

Zheng YF, Zheng YM, Liu XQ. Natural environments and adolescent depression: A literature review. World J Psychiatry 2026; 16(4): 115550

2026-04-19 | Browse: 173 | Download: 69

Yu W, Wang F. Analysis of emergency adolescent antidepressant poisoning incidence and family psychological environment influencing factors. World J Psychiatry 2026; 16(4): 115520

2026-04-19 | Browse: 179 | Download: 88

Dong S, Mou HL, Zhang H, Ye T. Correlation analysis of depressive symptoms and immune function indicators in patients with malignant melanoma. World J Psychiatry 2026; 16(4): 115490

2026-04-19 | Browse: 179 | Download: 93

Zeng Y, Yang X, Zhang XB, Liu Y, Sun J. Risk factors associated with anxiety and depression in patients with inflammatory bowel disease identified using structural equation modeling. World J Psychiatry 2026; 16(4): 115468

2026-04-19 | Browse: 179 | Download: 90

Zeng WF, Zhang Q, Wang XR, Xu ZY, Huang CW, Zhang QQ, Yan HL, Wang YX. Efficacy evaluation of an affectionate touch-based psychological intervention program for in vitro fertilization-embryo transfer patients: A controlled trial. World J Psychiatry 2026; 16(4): 115400

2026-04-19 | Browse: 205 | Download: 115

Lucas IC, Filgueira NA, Domingues AL, Lopes EP, Albuquerque IKP, Barbosa BJAP. Multidimensional cognitive impairment in hepatosplenic schistosomiasis: A cross-sectional study. World J Psychiatry 2026; 16(4): 115373

2026-04-19 | Browse: 175 | Download: 94

Jing P, Liu XC, Yin XP, Fu Y, Tian Q, Zhang XB. Progress on the neurotrophic effects of antidepressant drugs. World J Psychiatry 2026; 16(4): 115300

2026-04-19 | Browse: 163 | Download: 77

Cai SY, Gu HL, Zhao LH, Chen H. Health ecology-based nursing impact on stigma, anxiety, and depression in young and middle-aged type 2 diabetes patients. World J Psychiatry 2026; 16(4): 115233

2026-04-19 | Browse: 150 | Download: 76

Shen ZS, Xu TL, Zhang YY, Jia YJ, Zhao Q, Li JG. Impact of checklist-based process reengineering on emergency stay duration, rescue success rate, and satisfaction in consciousness-disordered patients. World J Psychiatry 2026; 16(4): 115211

2026-04-19 | Browse: 163 | Download: 89

62792 items Read more >>

Featured Articles

Goldman A, Gonzalez G, Karpova SA, Buon L, Shammas MA, Mashimo H, Frank MH, Frank NY. Optimal cannabinoid-terpene combination ratios suppress mutagenicity of gastric reflux in normal and metaplastic esophageal cells. World J Gastroenterol 2026; 32(14): 111455

2026-04-03 | Browse: 16 | Download: 14

Zhang L, Wang MY, Wei SY, Su C, Hu SY, Ren XY, Liu YP, Liu C, Wan Y. Predicting gastrointestinal bleeding and audio biomarkers based on machine learning analysis of bowel sounds. World J Gastroenterol 2026; 32(14): 115162

2026-04-03 | Browse: 12 | Download: 15

Xia XQ, Sheng RF, Zheng RC, Dai YX, Yang L, Chu YH, Zhang H, Wu XR, Shi NN, Wang CY, Zeng MS, Wang H. Evidence-based radiologist-supervised automated Liver Imaging Reporting and Data System categorization for the diagnosis of hepatocellular carcinoma. World J Gastroenterol 2026; 32(14): 116041

2026-04-03 | Browse: 11 | Download: 16

2026-04-03 | Browse: 10 | Download: 16

Yang M, Olaoba OT, Chinwo SC, LeVasseur H, Zhou B, Kimchi ET, Staveley-O’Carroll KF, Li G. Roles of hepatic immunity in metabolic dysfunction-associated steatotic liver disease: Cellular and molecular mechanisms and clinical trials. World J Gastroenterol 2026; 32(14): 117396

2026-04-03 | Browse: 13 | Download: 11

2026-04-02 | Browse: 6 | Download: 17

Czukiewska E, Narowska D, Czukiewski T, Pasieka I, Kuźniar A. Co-occurrence of BRCA2 and NF1 mutations: clinical implications for tumor susceptibility, metabolic reprogramming, and diagnostic challenges. World J Clin Cases 2026; 14(10): 119088

2026-04-02 | Browse: 6 | Download: 16

2026-04-02 | Browse: 7 | Download: 15

D’Souza OK. Comparative evaluation of anesthetic efficacy of articaine vs lignocaine during root canal therapy in hypomineralized second primary molars. World J Clin Cases 2026; 14(10): 118053

2026-04-02 | Browse: 5 | Download: 19

Tziona EE, Emmanouilidou A, Stouras I, Omar CT, Koloka M, Savva A, Dimitrakopoulou K, Iosifidis G, Pazaitou-Panayiotou K, Michalopoulos N. Thyroid carcinoma of the pyramidal lobe: A narrative review of reported cases. World J Clin Cases 2026; 14(10): 118950

2026-04-02 | Browse: 9 | Download: 16

2026-03-30 | Browse: 28 | Download: 47

2026-03-30 | Browse: 27 | Download: 46

Wang DY, Yuan MY, Zhi H. Comorbid depression and glycemic instability in adolescent type 1 diabetes: Clinical insights into suicide risk. World J Psychiatry 2026; 16(4): 117207

2026-03-30 | Browse: 26 | Download: 24

Jing P, Liu XC, Yin XP, Fu Y, Tian Q, Zhang XB. Progress on the neurotrophic effects of antidepressant drugs. World J Psychiatry 2026; 16(4): 115300

2026-03-30 | Browse: 30 | Download: 36

Biswas MS, Mawa MJ. Different treatments, different minds: The overlooked side of ovarian cancer care. World J Psychiatry 2026; 16(4): 114973

2026-03-30 | Browse: 31 | Download: 38

Zhang WF, Fan WT, Gao WW, Wu Z, Liu RR, Ruan CW. Crohn’s disease-related perianal fistula: A clinic research. World J Gastrointest Surg 2026; 18(3): 117693

2026-03-27 | Browse: 38 | Download: 51

Yolsuriyanwong K, Jubprang S, Winiyakul N, Cheewatanakornkul S, Wangkulangkul P, Promchan D. Incidence and predictors of gallstone disease after bariatric surgery in a Thai population. World J Gastrointest Surg 2026; 18(3): 116602

2026-03-27 | Browse: 41 | Download: 43

Liu SY, Xie XY, Zhang KN, Ma YQ, Ababakri A, Hao HZ, Zhang L, Guo QJ, Yu XH, Xie Y, Jiang WT. Risk factors and nomogram prediction of postoperative incisional hernia following liver transplantation: A retrospective cohort study. World J Gastrointest Surg 2026; 18(3): 115191

2026-03-27 | Browse: 40 | Download: 76

Shan Y, Zhang HX, Jiao Y. Traditional Chinese medicine acupuncture for postoperative nausea and vomiting after cholecystectomy: Mechanistic insights and clinical evidence. World J Gastrointest Surg 2026; 18(3): 115158

2026-03-27 | Browse: 36 | Download: 46

Wei J, Zhang MC, Shen YH, Jiao Y, Liu YH. Integrating traditional Chinese medicine with modern surgery: A comprehensive approach to complex anal fistula. World J Gastrointest Surg 2026; 18(3): 114917

2026-03-27 | Browse: 31 | Download: 22

10622 items Read more >>

Keyword Search Published Articles Processes

Case report

4759

Hepatocellular carcinoma

1764

Gastric cancer

1289

Colorectal cancer

1270

Prognosis

1094

Inflammatory bowel disease

865

COVID-19

847

Treatment

778

Diagnosis

761

Liver transplantation

749

Ulcerative colitis

693

Meta-analysis

677

Crohn’s disease

629

Endoscopy

624

Cirrhosis

615

Inflammation

603

Helicobacter pylori

597

Magnetic resonance imaging

589

Surgery

562

Pancreatic cancer

520

68192 items Read more >>

Reader Comments

"This cohort study has provided a review on the pediatric gastroenterology disease using genomic methods in Middle Eastern area. Hope ..." [Read more]

"This cohort study has provided a review on the pediatric gastroenterology disease using genomic methods in Middle Eastern area. Hope that the flowchart to collect the proper cases in this study can be explained in view of author's efforts. In addition, the total candidate patients number may be added for solid foundation if possible. " [Collapse]

Alsarhan A, Alloush R, Jain R, Abou Tayoun A, Tzivinikos C. Clinical utility of genomic investigations in a Middle Eastern pediatric gastroenterology disease cohort. World J Gastroenterol 2026; 32(13): 115810

"The article is written at a high scientific level. The research topic is relevant and in demand. The study design is described in ..." [Read more]

"The article is written at a high scientific level. The research topic is relevant and in demand. The study design is described in detail and fully meets its stated objectives. The statistical methods used are sound and enable an adequate evaluation of the results obtained. The data obtained are clearly presented in both tabular and graphical forms. The discussion of the obtained data is logical, and the resulting conclusions are well-reasoned. The only caveat: for an article of this caliber, more references to sources from recent years would be desirable – in this case, of the 44 references, only 50% are from the last five years. " [Collapse]

"The important value of this study lies in its clear finding that lean MASLD patients show no statistically significant differences ..." [Read more]

"The important value of this study lies in its clear finding that lean MASLD patients show no statistically significant differences from non-lean MASLD patients in terms of MASH, cardiovascular disease, and mortality risk, while their risks of cirrhosis, hypertension, and liver fibrosis are actually lower. The core clinical implication of this finding is that normal BMI should not be a reason to relax screening and risk assessment for MASLD and its complications. Of course, the study also has limitations: the definition of 'lean' varies across studies, which may introduce classification bias; and some outcomes (e.g., mortality, MASH, fibrosis) show high heterogeneity (I² > 90%), requiring cautious interpretation. Nevertheless, this is a study with direct practical guidance for clinical practice, particularly suitable for readers in hepatology, cardiology, endocrinology, and general medicine, as it helps shift MASLD screening strategies from an obesity-centered approach to multidimensional metabolic risk assessment. " [Collapse]

Mapouka M, Pabingui E, Tazinkeng NN, Gurmessa M, Vickos U, Ndemazie NB, Camengo Police SM. Outcomes of liver and cardiovascular metabolic diseases among lean vs non-lean individuals with metabolic dysfunction-associated steatotic liver disease. World J Gastroenterol 2026; 32(13): 114657

"The authors integrated multiple GEO datasets, combined bioinformatics methods such as WGCNA and LASSO, and identified four ..." [Read more]

"The authors integrated multiple GEO datasets, combined bioinformatics methods such as WGCNA and LASSO, and identified four exercise-responsive skeletal muscle genes (LAMA4, PECAM1, PXDN, THBS4), which were subsequently validated in an animal model. The study is clear in its approach and logically coherent. Its value lies in moving beyond the general attribution of exercise-induced improvement in MASLD to simply weight loss or metabolic improvement, instead attempting to pinpoint specific molecular mediators from the perspective of muscle–liver crosstalk. In particular, the detectability of PECAM1 and THBS4 in serum suggests their potential as liquid biopsy biomarkers or myokine-like candidates, offering reference value for the future development of exercise-mimetic drugs or precision intervention strategies. " [Collapse]

Zhang JH, Chen K, Zhu XM, Zhou H, Jiang JM, Zou YQ, Liu KR, Zhang L, Li Y. Exercise-responsive skeletal muscle genes mechanistically linked to metabolic dysfunction-associated steatotic liver disease. World J Gastroenterol 2026; 32(13): 113985

"This is a well-organized and potentially meaningful study investigating exercise-responsive skeletal muscle biomarkers in MASLD. The ..." [Read more]

"This is a well-organized and potentially meaningful study investigating exercise-responsive skeletal muscle biomarkers in MASLD. The integration of multiple GEO datasets, combined with WGCNA, LASSO modeling, validation cohort analysis, and animal experiments, represents a comprehensive approach. The identification of candidate genes involved in muscle-liver communication is of interest and may contribute to a better understanding of the mechanisms underlying the beneficial effects of exercise in MASLD. Nevertheless, one issue should be clarified. In the “Identification of DEGs” section and in Figure 1, the authors indicate that GSE161749, GSE48278, GSE156247, and GSE53598 were included. However, in Figure 2A/2B, the PCA legend appears to include GSE72462 instead of GSE156247. Please clarify which dataset was actually used and correct the figure or text accordingly. " [Collapse]

"The gut–muscle axis shares its conceptual underpinnings with the gut–lung axis, encompassing bidirectional crosstalk driven by gut ..." [Read more]

"The gut–muscle axis shares its conceptual underpinnings with the gut–lung axis, encompassing bidirectional crosstalk driven by gut dysbiosis, microbial translocation, immune dysregulation, and epigenetic modification. Short-chain fatty acids (SCFAs) — most notably butyrate — serve as the principal metabolic intermediary, promoting skeletal muscle protein synthesis and mitochondrial integrity through FFAR2/FFAR3 receptor signaling, AMPK–PGC-1α pathway activation, and PI3K/Akt/mTOR-mediated anabolism, while simultaneously exerting epigenetic regulation via histone deacetylase (HDAC) inhibition. A mechanistically distinctive feature of the gut–muscle axis is robust retrograde signaling from muscle to gut. Exercise-derived lactate directly fuels SCFA-producing bacteria, and muscle-secreted myokines actively modulate microbial diversity — thereby constituting an actionable, bidirectional feedback loop with no clear counterpart in the gut–lung axis. Furthermore, gut microbiota-derived secondary bile acids activate farnesoid X receptor (FXR) and Takeda G protein-coupled receptor 5 (TGR5) in skeletal muscle, representing a pathway of particular relevance to gut–muscle biology. Clinically, dysbiosis-driven SCFA depletion accelerates sarcopenia in aging populations, whereas patients with inflammatory bowel disease (IBD) face compounded muscle wasting attributable to chronic inflammation and nutrient malabsorption. Therapeutic strategies — encompassing probiotics, fecal microbiota transplantation (FMT), and butyrate supplementation — mirror those proposed for the gut–lung axis, with multi-omics integration and AI-driven analytics defining the shared frontier of precision medicine. In summary, the gut–muscle axis both extends and substantively complements the gut–lung axis paradigm. Crucially, physical activity emerges as a uniquely potent bidirectional therapeutic modality, making it particularly suited for addressing muscle wasting in IBD and aging populations. " [Collapse]

Huang HJ, Liu PP, Dong DF. Research progress on comorbidity between gastrointestinal and pulmonary diseases from the perspective of the gut-lung axis. World J Gastroenterol 2026; 32(11): 115846

"I thank Khan et al for conducting this meta-analysis and finding out that hypoalbuminemia is a risk factor for mortality in ..." [Read more]

"I thank Khan et al for conducting this meta-analysis and finding out that hypoalbuminemia is a risk factor for mortality in cholangitis. I have a few comments that have to be taken into account while interpreting this study. First, this meta-analysis includes only retrospective studies. Second, there is no subgroup analysis by benign versus malignant aetiology of acute cholangitis. The outcomes of cholangitis depend on aetiology, which is not studied. This indicates whether hypoalbuminemia is due to cholangitis as an acute-phase reactant, or whether any underlying aetiology needs to be identified. Whether any intervention in acute cholangitis with hypoalbuminemia has any role in the outcome has not been studied. However, this meta-analysis provides meaningful research questions for future prospective studies. " [Collapse]

Khan RTY, Ahsam S, Kumar SK, Khan K, Kakar MT, Hyder A, Malik W, Mubarak M, Luck NH. Hypoalbuminemia as a predictor of mortality in patients with acute cholangitis: A systematic review and meta-analysis. World J Gastrointest Pathophysiol 2026; 17(1): 113373

"Sheriefet al. [1]demonstrated dual parametric evaluation to assess diagnostic performance for Hepatocellular carcinoma (HCC), ..." [Read more]

"Sheriefet al. [1]demonstrated dual parametric evaluation to assess diagnostic performance for Hepatocellular carcinoma (HCC), discriminating from Hepatitis C-related liver Cirrhosis and Healthy control cohorts via plasma in a single centred Egyptian population.This study [1] revealed two leading biomarkers with exceptional accuracy (AUC >0.99); hsa-miR-21-5p (Sensitivity and Specificity of 98.6% and 96.7%, respectively) and Leukocyte-associated immunoglobulin-like receptor-1(LAIR-1) mean fluorescence intensity (MFI) (Sensitivity and Specificity of 100 % and 98.3%, respectively). Sherief et al. [1]aims to address one of the clinically challenging issues i.e. lack of sensitive, specific circulatory biomarker/s for early diagnosis of Hepatocellular Carcinoma (HCC).Commentary noted several strengths of the study by Sherief et al. [1],such as; looks technicallymoderatein study design, methodology and innovation level i.e. prospective study, minimally invasive sample collection, exploration of dual parameters: tumour derived circulatory micro-RNA and immune related marker. Additionally, study employed rigorous statistical analysis for diagnostic performance assessment including ROC curve analysis, comparative Sensitivity/Specificity,revealed promising findings that may pave for future research towards biomarkers validation and discovery. However,present commentary observed several concerns for the study by Sherief et al. [1]; (i) Lack of mechanistic cascade exploration including causal pathway/s.(ii) Median age of HCC cohort is significantly higher than Hepatitis C-related liver Cirrhosis and Healthy control, may be a biasing factor in expression pattern. (iii) Since study did not include follow up subjects that limits for probing of prognostic markers. (iv) Paucity of multi-centric involvement for diversified population, may limit the findings for generalized conception. (v) Validation of findings through blinded samples may demonstrate a better decision regarding applicability. (vi) Authors used word ‘noninvasive’, for plasma-based markers investigation(vii) Global Cancer statistics 2022,wasalready published in 2024[2], still authors used GLOBOCON 2020 [3] reference in epidemiological outline in the manuscript [1], latest reference can provide contemporary status. The article by Sherief et al. [1], demonstrated balanced and structured scientific contents along with logical explanations. However, addition of graphical abstract to present the study in nutshell may improve the visibility for readers. A large sample sized, multi-centered,longitudinal study, involving diversified geographical and ethnic population of HCC, Hepatitis C-related liver Cirrhosis, Healthy control cohorts, and mechanistically relevant subgroups, using common protocol, validation through blinded samples, may provide potential edge for HCCdiagnosticsto achieve common consensus and identification of prognostic biomarkers. Integrated nomogram ofhsa-miR-21-5p with LAIR-1 MFI, may be explored for possible better diagnosticsetup. Application of Artificial Intelligence (AI) may be explored for diagnostic performance as well as high throughput outcomes. References: 1. Sherief DE, Shehata HH, Nosair N, Othman AAA, Sadaka E, Elgamal R. Dual-parameter liquid biopsy using plasma miR-21-5p and T cell LAIR-1 mean fluorescence intensity for hepatocellular carcinoma diagnosis in a high-risk Egyptian cohort. World J Gastrointest Oncol 2026 March 15a; 18(3): 116567. 2. Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, Jemal A. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for36 cancers in185 countries. CA Cancer J Clin. 2024; 74:229–263 3. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin 2021; 71: 209-249 " [Collapse]

Sherief DE, Shehata HH, Nosair N, Othman AAA, Sadaka E, Elgamal R. Dual-parameter liquid biopsy using plasma miR-21-5p and T cell LAIR-1 mean fluorescence intensity for hepatocellular carcinoma diagnosis in a high-risk Egyptian cohort. World J Gastrointest Oncol 2026; 18(3): 116567

"I read with ken interest about the following article. As a reader I have few comments/ suggestions also. Alok Bharadwaj, Manas Taneja, ..." [Read more]

"I read with ken interest about the following article. As a reader I have few comments/ suggestions also. Alok Bharadwaj, Manas Taneja, Sneha Dubey, Aditya Saxena. Very low-density lipoprotein and the human health. World J Exp Med 2026;16(1): 117024 [DOI: 10.5493/wjem.v16.i1.117024] Abstract Apo B100, TGL and cholesterol are present in LDL in addition to VLDL. But the ratio of TGL: cholesterol may vary. PATHOLOGICAL ROLE OF VLDL: Metabolism-associated fatty liver disease and liver disease: Distinction between NAFLD, MAFLD and MASLD may be provided Following the classification of metabolic dysfunction-associated fatty liver disease (MAFLD), non-alcoholic fatty liver disease (NAFLD) has recently been redefined again as metabolic dysfunction-associated steatotic liver disease (MASLD). Both MASLD and MALFD were linked to higher all-cause mortality risk, but MASLD identified a greater number of individuals compared to MAFLD. (Song R, Li Z, Zhang Y, Tan J, Chen Z. Comparison of NAFLD, MAFLD and MASLD characteristics and mortality outcomes in United States adults. Liver Int. 2024;44:1051-1060. doi:10.1111/liv.15856) Metabolic-associated fatty liver disease (MAFLD) exhibits a raised VLDL secretion rate attributed to increased intrahepatic TGs hydrolysis. They apparent the absence of immediate VLDL secretion reduction yet maintained a consistent apo B100 secretion rate, as informed by previous studies/ I would like to reframe this sentence: in the presence of elevated counter-regulatory hormones, lipolysis takes place in the adipose tissue releasing free fatty acids into circulation. Majority of these fatty acids are take up liver and converted into triglycerides. If VLDL secretion from liver is not proportionate to the level of fatty acid entry into liver, fatty acids may get accumulated in the liver causing different forms of fatty liver. In individuals with insulin resistance and higher body weight, there is an elevation in apo C-III levels within VLDL. Apo CIII is an inhibitor of lipoprotein lipase, thus inhibiting lipolysis of TGL in VLDL, thus increasing VLDL concentration in blood. Insulin resistance and MetS Insulin-hampered VLDL production, along with insulin resistance, leads to increased and decreased production of VLDL, often associated with hypertriglyceridemia Does VLDL increase or decrease with insulin resistance Hepatic VLDL production is decreased by glucagon Mechanism behind this Alterations of VLDL in various disorders have been explained well. All the mechanistic pathways have been adequately addressed " [Collapse]

Bharadwaj A, Taneja M, Dubey S, Saxena A. Very low-density lipoprotein and the human health. World J Exp Med 2026; 16(1): 117024

"This letter to the Editor notes the potential significance of clinical situation in patients who suffer from emphysematous ..." [Read more]

"This letter to the Editor notes the potential significance of clinical situation in patients who suffer from emphysematous pyelonephritis. This is very important. Clinical findings and symptoms must be the cornestone in these conditions in order to avoid the worse outcomes of patients. In addition, the Modified National Early Warning Score 2 based on physiological situation of patient shoud be very helpfull, as well as computed tomography findings. " [Collapse]

Sevik C, Erbin A, Canat HL. Integrating Modified National Early Warning Score 2, computed tomography staging, and laboratory markers for enhanced prognostic stratification in emphysematous pyelonephritis. World J Nephrol 2026; 15(1): 113952

"This manuscript defined as Editorial is generally good, but it mildly offers new lights in concept of diabetic nephropathy ..." [Read more]

"This manuscript defined as Editorial is generally good, but it mildly offers new lights in concept of diabetic nephropathy complications and its progression in death. Pathophysiology paragragh is better than the other parts of manuscript. Addiotionally, inequalities and differences between racial and ethic groups were noted, which is not usual in other published manuscripts. " [Collapse]

Gembillo G, Ricca MF, Santoro D. Diabetes-related renal complications: Insights on the impact of diabetic kidney disease on mortality. World J Nephrol 2026; 15(1): 108432

"Reader’s code: 00106360 Commentary on the Article Impact of metabolic dysfunction-associated steatotic liver disease on liver ..." [Read more]

"Reader’s code: 00106360 Commentary on the Article Impact of metabolic dysfunction-associated steatotic liver disease on liver metastasis and survival in pancreatic cancer The study by Chon HY et al. examines the impact of metabolic dysfunction-associated steatotic liver disease (MASLD) on liver metastasis and survival in patients with Pancreatic Ductal Adenocarcinoma. Using a large retrospective cohort of 2123 patients, the authors assessed hepatic steatosis primarily through the hepatic steatosis index (HSI) and additionally validated findings using CT-based measurements of liver fat. The study found no significant association between MASLD and the presence of liver metastasis at diagnosis or during follow-up, suggesting that hepatic steatosis may not be a key determinant of metastatic spread in pancreatic cancer (Chon et al., 2026). The findings contrast with previous research in other malignancies, such as colorectal and breast cancers, where hepatic steatosis has been reported to influence liver metastasis risk or metastasis-free survival (van Saane et al., 2019; Wu et al., 2020). In the present study, tumor size and elevated CA19-9 levels were the main predictors of liver metastasis, while diabetes mellitus was associated with improved survival outcomes, possibly reflecting earlier detection among diabetic patients (Chon et al., 2026). Critical Appraisal of the Study The study by Chon HY and colleagues evaluates the relationship between metabolic dysfunction-associated steatotic liver disease (MASLD) and liver metastasis in patients with Pancreatic Ductal Adenocarcinoma. Using a large retrospective cohort of 2123 patients, the authors investigated whether hepatic steatosis, measured by the hepatic steatosis index (HSI), influences the development of liver metastasis and overall survival. Strengths One of the major strengths of this study is its large sample size and long study period (2006–2021), which enhances the statistical power and reliability of the findings. The authors used robust statistical methods, including logistic regression and Cox proportional hazards models, to analyze risk factors for both baseline and newly developed liver metastases. Another notable strength is the additional CT-based validation in a subgroup of patients, which helps corroborate the HSI-based assessment of hepatic steatosis. The study also carefully adjusted for multiple potential confounders such as age, BMI, diabetes, lipid profile, tumor size, and CA19-9 levels. Limitations Despite these strengths, several limitations should be considered. First, the retrospective design limits the ability to establish causal relationships. Second, the primary assessment of hepatic steatosis relied on the HSI, an indirect surrogate marker derived from BMI and liver enzyme ratios, which may be influenced by cancer-related factors such as cachexia, inflammation, or biliary obstruction. Third, important pathological variables (e.g., lymph node status, lymphovascular invasion, and perineural invasion) were not consistently available and therefore could not be included in the multivariate models. Additionally, the CT-based validation was limited to a subset of patients, which may introduce selection bias. Clinical Implications Clinically, the findings suggest that MASLD may not be a significant determinant of liver metastasis in pancreatic cancer, contrasting with observations in other malignancies. Instead, established markers such as tumor size and elevated CA19-9 levels appear to remain more reliable predictors of metastatic risk and mortality. These results highlight the aggressive biological behavior of pancreatic cancer, where tumor-driven mechanisms may outweigh the influence of underlying hepatic metabolic conditions. Future prospective studies incorporating advanced imaging, histologic confirmation, and molecular analysis of the tumor–liver microenvironment are needed to further clarify the role of MASLD in pancreatic cancer progression. Despite its strengths, including a large sample size and robust statistical modeling, the retrospective design and reliance on HSI rather than histologic confirmation limit the ability to establish causality. Nevertheless, this study contributes important evidence suggesting that the relationship between MASLD and metastasis may be cancer-specific and biologically complex. Reference Chon HY, Rhee H, Kim J, et al. Impact of metabolic dysfunction-associated steatotic liver disease on liver metastasis and survival in pancreatic cancer. World Journal of Gastroenterology. 2026;32(11):115488. van Saane AM, et al. Non-alcoholic fatty liver disease and colorectal liver metastasis risk. Liver International. 2019. Wu W, et al. Hepatic steatosis and liver metastasis-free survival in breast cancer. Cancer Medicine. 2020. " [Collapse]

Chon HY, Rhee H, Kim J, Leem G, Jo JH, Chung MJ, Park JY, Bang S, Park SW, Kim SU, Lee HS. Impact of metabolic dysfunction-associated steatotic liver disease on liver metastasis and survival in pancreatic cancer. World J Gastroenterol 2026; 32(11): 115488

"Esophageal variceal bleeding is one of the most severe complications of cirrhotic portal hypertension, associated with high rates ..." [Read more]

"Esophageal variceal bleeding is one of the most severe complications of cirrhotic portal hypertension, associated with high rates of rebleeding and mortality. Although endoscopic variceal band ligation (EVBL) is currently the standard treatment, its reliance on repeated endoscopic follow-up presents challenges, including invasiveness, high resource consumption, and poor patient tolerance. This study focuses on the potential application of multiparametric ultrasound (MP-US) in predicting outcomes following EVBL, proposing a novel follow-up strategy that is noninvasive, individualized, and reproducible, with significant promise for clinical translation. The article begins with the clinical burden of EVB, progressively introduces the limitations of current diagnostic and therapeutic approaches, and naturally transitions to the technical advantages and research evidence supporting MP-US, culminating in future research directions. The structure is well-organized, and the logic is rigorous. The critical analysis of existing technologies is insightful. The article objectively highlights the limitations of HVPG and repeated endoscopy, particularly their inaccessibility in resource-limited settings. It also provides a reasonable evaluation of the shortcomings of noninvasive tools such as the Baveno criteria and elastography in predicting postprocedural outcomes, reflecting the authors' deep understanding of clinical realities. The analysis of MP-US's clinical application is thorough. By integrating measurements of liver stiffness, spleen stiffness, and perfusion imaging, MP-US enables a comprehensive assessment of portal hypertension from both structural and hemodynamic perspectives, overcoming the limitations of traditional single-parameter prediction models. Citing data from Ainora et al, the study demonstrates the potential of MP-US in predicting variceal eradication and guiding individualized follow-up. The outlook on future research directions is instructive. The article notes that current studies are mostly small-sample, single-center designs lacking standardized operating and interpretation protocols, and calls for multicenter, prospective studies to validate the clinical value of MP-US—a recommendation with practical significance. Figure 1 is highly informative, clearly illustrating the evolutionary pathway from invasive to noninvasive diagnostic tools, facilitating readers' understanding of technological advancements. Areas for improvement and suggestions: The issue of MP-US technical standardization requires further clarification. Although the article mentions that MP-US is influenced by factors such as operator experience and equipment variability, it does not delve deeply into how to achieve standardized operation and interpretation; future research should focus on this aspect. A cost-effectiveness analysis is lacking. While MP-US has the potential to reduce the frequency of endoscopic examinations, its high equipment costs and reliance on contrast agents may limit its widespread adoption in certain regions. Future studies should incorporate health economic evaluations. The integration of AI with MP-US warrants further exploration. The article mentions the application of AI in endoscopic measurement but does not explore the possibility of combining AI with MP-US. Future research could investigate AI-based automated analysis of MP-US images and risk prediction models. This study, with its clear logic, solid literature support, and forward-looking perspective, systematically elaborates on the potential application of MP-US in post-EVBL follow-up. It not only provides clinicians with new diagnostic and therapeutic insights but also points future researchers toward promising directions. If further advancements are made in MP-US standardization, multicenter validation, and AI integration, it holds the potential to achieve truly noninvasive, precise, and individualized management of portal hypertension in patients with cirrhosis. " [Collapse]

"This systematic review of 8 randomized trials (1758 participants) rigorously evaluates adjunctive pharmacotherapies for diuretic ..." [Read more]

"This systematic review of 8 randomized trials (1758 participants) rigorously evaluates adjunctive pharmacotherapies for diuretic resistance in acute decompensated heart failure (ADHF), adhering to PRISMA guidelines and using Cochrane’s RoB 2.0 for bias assessment. Key findings show proximal nephron-targeted agents (acetazolamide, SGLT2 inhibitors) and distal thiazide diuretics effectively boost decongestion: acetazolamide raises successful decongestion rates (42.2% vs 30.5%), SGLT2 inhibitors enhance urine output and reduce worsening HF, while thiazides prompt greater weight loss but increase renal dysfunction risk. Notably, older agents (high-dose spironolactone, low-dose dopamine/nesiritide) yield no meaningful clinical benefits. The review’s strength lies in its exclusive focus on randomized trials, but heterogeneity in endpoints and short follow-up limit generalizability. It provides a mechanistically guided, stepwise clinical framework for ADHF management, emphasizing personalized adjunct selection, and identifies the need for large head-to-head trials and long-term outcome research to address existing evidence gaps. " [Collapse]

Patel V, Zameer R, Kumar B, Das M. Adjunctive pharmacologic therapies for diuretic resistance in acute decompensated heart failure: Systematic review of randomized trials. World J Meta-Anal 2026; 14(1): 118496

"The article raises critical issues regarding healthcare expenditure and the anesthesiologist’s responsibility in cost containment. ..." [Read more]

"The article raises critical issues regarding healthcare expenditure and the anesthesiologist’s responsibility in cost containment. While the narrative is informative, a more quantitative economic comparison and inclusion of updated guidelines or contemporary practice data would strengthen the conclusions. Additionally, deeper exploration of medico-legal concerns and institutional resistance could enhance its practical impact. Nevertheless, the review addresses a clinically meaningful topic. " [Collapse]

Karim HMR. Healthcare delivery cost and anesthesiologists: Time to have a greater role and responsibility. World J Anesthesiol 2019; 8(3): 19-24

"I read with great interest the study by Khalifa et al. published in the World Journal of Orthopedics, evaluating the impact of surgeon ..." [Read more]

"I read with great interest the study by Khalifa et al. published in the World Journal of Orthopedics, evaluating the impact of surgeon handedness on radiological and functional outcomes following primary total knee arthroplasty (TKA). The authors should be commended for addressing an underexplored yet clinically relevant surgeon-related variable in arthroplasty practice. The finding that overall limb alignment and functional outcomes were not significantly influenced by operating on the dominant versus non-dominant side is reassuring. However, the increased incidence of tibial component malalignment (MPTA outliers) on the non-dominant side highlights an important technical nuance that may have implications for implant longevity, particularly in mechanically aligned TKA performed with conventional instrumentation. The subgroup analysis comparing intramedullary and extramedullary tibial guides is particularly interesting, suggesting that technique selection may interact with laterality. These findings underscore the potential value of ergonomic optimization and heightened intraoperative vigilance when operating on the non-dominant side. Future prospective studies incorporating sagittal and rotational alignment parameters, inclusion of left-handed surgeons, and long-term survivorship data would further clarify the clinical significance of these observations. Additionally, evaluating whether navigation or robotic assistance mitigates the subtle asymmetries associated with surgeon handedness could provide valuable insights. Overall, this study contributes meaningfully to the ongoing discussion regarding modifiable surgeon-related factors influencing TKA precision and outcomes. " [Collapse]

Khalifa AA, Abdelaal AM, Moustafa MM. Does surgeon handedness affect the outcomes after primary total knee arthroplasty? A retrospective cohort study. World J Orthop 2026; 17(2): 113696

"I would like to congratulate the authors on this clinically relevant study. The authors provided a conclusion that differs from ..." [Read more]

"I would like to congratulate the authors on this clinically relevant study. The authors provided a conclusion that differs from previously published results. ETV is generally considered renal-neutral and is commonly used in DCLD due to its renal safety. The statement that ETV is associated with a greater decrease in GFR than TMV is overfitting, as it is a retrospective study. The Difference in decline of approximately 4 mL/min/1.73 m² is very small and may not be clinically meaningful in patients with normal GFR, even though it is statistically significant. The conclusion should be interpreted with caution and requires additional long-term prospective studies to substantiate this claim. Furthermore, the authors did not report any additional adverse events during the study period. " [Collapse]

Ma SP, Wang L, Zhang YL, Wan X, Liu Q, Tang YL, Malhi LR, Ge SF. Effects of tenofovir amibufenamide and entecavir on estimated glomerular filtration rate in treatment-naïve patients with chronic hepatitis B. World J Hepatol 2026; 18(2): 114346

"I congratulate the authors on this relevant study on this study. As the authors pointed out, Klebsiella is the leading cause of liver ..." [Read more]

"I congratulate the authors on this relevant study on this study. As the authors pointed out, Klebsiella is the leading cause of liver abscesses in Asia and is increasingly prevalent in India. It is important to have culture reports at various time points, as they will help us in deciding empirical antibiotics. The authors have shown that the isolated organisms are highly resistant to ampicillin and have low resistance to cephalosporins and carbapenems. With this large amount of data, the authors would have identified the poor prognostic predictors of PLA and treatment outcome. The authors did not present the data on complications of these abscess such as biliary fistula " [Collapse]

Mai-Phan TA, Thai KP, Le KL, Pham TN, Tran MQ, Pham PC, Duong NNQ, Trinh MT, Le NK. Klebsiella pneumoniae as leading cause of pyogenic liver abscess: Three years study in Southern Vietnam. World J Hepatol 2026; 18(2): 113695

"Wang and Pan present an editorial that meaningfully extends the discussion of ERAS in elderly gastric cancer patients beyond ..." [Read more]

"Wang and Pan present an editorial that meaningfully extends the discussion of ERAS in elderly gastric cancer patients beyond feasibility toward biologically grounded recovery. Building on prior evidence by Li et al. demonstrating the safety and protocol adherence of ERAS in older adults. The authors appropriately emphasize physiological heterogeneity, frailty, and resilience as key determinants of postoperative outcomes rather than chronological age alone. The proposed multidomain framework integrating nutritional inflammatory balance, circadian regulation, psychological resilience, and digital monitoring, offers an important conceptual advance. However, many of these strategies rely on resource intensive multidisciplinary teams, biomarker surveillance, and wearable technologies, which may limit generalizability outside high-volume or well-resourced centers. Future efforts may benefit from parallel development of simplified, scalable ERAS adaptations for elderly patients. Overall, this editorial provides a valuable roadmap for evolving ERAS from protocol compliance toward patient-centered, biologically informed recovery in an aging surgical population. " [Collapse]

Wang G, Pan SJ. From feasibility to biological recovery: Reframing enhanced recovery pathways after surgery in elderly gastric cancer patients. World J Gastroenterol 2026; 32(7): 116264

"This Editorial thoroughly explores the field of AI use in diagnostic radiology. It provides a complete overview of the potential and ..." [Read more]

"This Editorial thoroughly explores the field of AI use in diagnostic radiology. It provides a complete overview of the potential and the current applications of AI in the field with great potential, strong diagnostic performance but in my opinion it does spotlight with the due consideration the potential drawbacks coming from the extensive use of AI in the clinical field. The enthusiasm generated from the high precision and performance and the consequent advantages in terms of resource and time save for operators outpaced evaluation of broader consequences. Concerns include trainee deskilling, automation bias, unclear medicolegal accountability, and inequitable access due to infrastructure demands. The authors emphasize that technical accuracy alone is insufficient and call for longitudinal studies, training models that preserve independent reasoning, and deployment strategies that address equity. Without systematic assessment of professional, clinical, and societal impacts, AI adoption risks being driven by non-evidence-based factors. " [Collapse]

He ZX, Wang J, Yang JS. Expanding the applications of artificial intelligence in emergency radiology: Advancing precision medicine and resource efficiency. World J Radiol 2026; 18(1): 117814

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