Baishideng Publishing Group

Yang D, Kim B, Kim JW. Mechanistic insights into hepatic cell type-specific contributions to acetaminophen-induced acute liver injury. World J Gastroenterol 2025; 31(45): 112720

"On behalf of all authors, I would like to express our sincere gratitude to the Editor and the Reviewers for their valuable time and ..." [Read more]

"On behalf of all authors, I would like to express our sincere gratitude to the Editor and the Reviewers for their valuable time and constructive comments. Their insightful suggestions have significantly helped us in improving the clarity, logic, and scientific rigor of this manuscript. We have carefully addressed all points raised during the peer-review process. The revised version has been strengthened through additional explanations, refined data presentation, and more precise language. We believe these revisions have enhanced the overall quality and impact of our work, making it more valuable for the readership of the World Journal of Gastroenterology. We appreciate this opportunity to contribute to the field. Look forward to your feedback and citations. " [Collapse]

Wang J, Chang L, Niu DF, Yan Y, Cao CQ, Li SJ, Wu Q. Diagnostic accuracy of stereomicroscopy assessment of invasion depth in ex vivo specimens of early gastric cancer. World J Gastroenterol 2025; 31(45): 112518

"Through the joint efforts of the assistant editor, editor, peer reviewers, editorial director, editor-in-chief, language editor, and ..." [Read more]

"Through the joint efforts of the assistant editor, editor, peer reviewers, editorial director, editor-in-chief, language editor, and production editor, the entire publication process for this manuscript has been completed. This article was further revised and improved, and was successfully published in World Journal of Gastroenterology. I would like to express my gratitude to all of you for your efforts. " [Collapse]

Zhang N, Wang Y, Fang SS, Han M, Zheng QW, Zhu YY, Zhang MY, Li JJ, Cui LX, Tian JL, Deng YH, Zhu SL, Ni HM, Zhou L, Zuo GL, Huang TS, Liao Q, Li XQ, Shang YY, Wang YJ, Tian Y, Ge LY, Han HQ, Hu WM, Jiang Y, Li YJ, Mao X, Yang LH, Yao JM, Zheng X, Wang HW, Fang SQ. Clinical characteristics and risk factors of refractory gastroesophageal reflux disease: A multicenter cross-sectional study. World J Gastroenterol 2025; 31(45): 113060

"I hold a high opinion of your journal’s services across all essential aspects: the well-prepared forms for online full-text submission, ..." [Read more]

"I hold a high opinion of your journal’s services across all essential aspects: the well-prepared forms for online full-text submission, the smooth article publication process, the clear provision of academic rules and standards, and the thorough academic misconduct detection report. The reasonable publication period, detailed editing and publishing norms, appropriate duration dedicated to peer review, and rigorous anonymous peer review process all meet my expectations. The peer review report has been particularly valuable for refining my manuscript, and I am confident in its fairness and objectivity as it focuses solely on academic merit. " [Collapse]

Lei ZL, Tan ZL, Luo YH, Yang M, Wang JL, Qin Z, Liu YY. Comparison of the efficacy of laparoscopic hepatectomy and radiofrequency ablation for small hepatocellular carcinoma: A retrospective study. World J Gastroenterol 2025; 31(45): 111540

"Overall, I am satisfied with the journal’s editorial and peer-review process. The submission system was easy to use, and the ..." [Read more]

"Overall, I am satisfied with the journal’s editorial and peer-review process. The submission system was easy to use, and the communication with the editorial office was clear and timely. The peer review reports were constructive and provided valuable guidance that helped improve the quality of the manuscript. The editorial team demonstrated professionalism throughout the process, and the final publication, including formatting, figures, and tables, met a high standard. However, there is still room for improvement. In particular, the duration of the review and publication process could be further optimized to enhance efficiency. Additionally, ensuring greater consistency in the depth and specificity of reviewers’ comments would further strengthen the peer review experience for authors. In summary, my overall experience with the journal has been positive, and I appreciate the efforts made by both reviewers and editors in maintaining academic rigor and publication quality. " [Collapse]

Zhang WY, Yang K, Zhai YC, Miao QS, Cui YH. Mental vulnerability, family dysfunction, and digital exposure: Overlooked burdens in populations with noncommunicable chronic diseases. World J Psychiatry 2025; 15(12): 112122

"We are highly satisfied with the submission and review system of this journal, which is also a journal of high academic value. We ..." [Read more]

"We are highly satisfied with the submission and review system of this journal, which is also a journal of high academic value. We will continue to submit our work. The efficiency and thoroughness of the review process have greatly contributed to our positive experience, reinforcing our commitment to sharing our research through this esteemed platform. " [Collapse]

Pan JL, Xing H, Li Y, Chang ZQ. Successful treatment of a non-healing lumbar incision post-radiotherapy using vacuum sealing drainage: A case report. World J Orthop 2025; 16(11): 112307

"Dear sir everthing is perfect, all the reviewer comments were structured highly scientific and helpful to improve manuscript quality ..." [Read more]

"Dear sir everthing is perfect, all the reviewer comments were structured highly scientific and helpful to improve manuscript quality and made the message from it more clear handeling by the editor was so proficinal regarding continuous follow up, rigorous revision i am so honored that my work published in your journal thank you so much " [Collapse]

Hegazy MAE. Artificial intelligence in metabolic dysfunction-associated steatotic liver disease: Machine learning for non-invasive diagnosis and risk stratification. World J Hepatol 2025; 17(11): 111354

"I am very pleased with my experience publishing in the World Journal of Clinical Cases through the F6Publishing platform. The ..." [Read more]

"I am very pleased with my experience publishing in the World Journal of Clinical Cases through the F6Publishing platform. The submission process was smooth, transparent, and well-organized, and the editorial team provided timely communication at every stage. The peer-review comments were constructive and helped enhance the quality of my work. Overall, I am fully satisfied and highly recommend this journal and publishing system to other researchers. " [Collapse]

Gecer IS, Tabaru A, Yilmaz B, Kaya E, Kaya Tutar N, Gumuslu B, Oktay MF. Medial olivocochlear reflex dysfunction in multiple sclerosis: The influence of brainstem lesion localization and its clinical implications. World J Clin Cases 2025; 13(28): 108180

"As an author, I was very satisfied with both the editorial and publishing process and the quality of peer review provided by the ..." [Read more]

"As an author, I was very satisfied with both the editorial and publishing process and the quality of peer review provided by the journal. Communication was clear and timely, the instructions were transparent, and the editorial handling was efficient and professional. The reviewers’ comments were constructive, specific, and scientifically sound, helping to improve the clarity and impact of the manuscript. Overall, I consider the journal reliable and its peer review process rigorous, fair, and respectful. " [Collapse]

Tarallo M, Crocetti D, Coppola A, Iannone I, Lamazza A, Sapienza P, Fiori E. Endoscopic retrograde cholangiopancreatography-related adverse events: What is the role of surgery today? World J Gastrointest Surg 2025; 17(7): 107385

"Our experience with the World Journal of Gastrointestinal Surgery has been exceptionally positive. The peer-review process for our ..." [Read more]

"Our experience with the World Journal of Gastrointestinal Surgery has been exceptionally positive. The peer-review process for our manuscript on asymptomatic gallstone disease was smooth, transparent, and conducted with admirable professionalism. We greatly appreciated the timely communication, constructive feedback, and consistent editorial support throughout the process. The efficiency and clarity demonstrated by the Baishideng Publishing Group made the publication journey both enriching and seamless. We extend our sincere thanks to the editors, reviewers, and the entire team for their commitment to high scientific standards. " [Collapse]

Sasmal PK, Singh PK, Sahoo A, Dutta T. Asymptomatic gallstone disease: Re-evaluating the threshold for surgical options in the era of precision medicine. World J Gastrointest Surg 2025; 17(11): 110501

"I would like to extend my sincere gratitude to the journal's editorial staff and the external reviewers. The editorial handling was ..." [Read more]

"I would like to extend my sincere gratitude to the journal's editorial staff and the external reviewers. The editorial handling was highly professional and efficient. The reviewers provided rigorous, insightful, and truly constructive feedback, which substantially improved the scholarly quality of the manuscript. The entire publication experience was excellent. Thank you. " [Collapse]

Liu Y, Shan XQ, Li YJ, Gao WL, Zhao L. Role of human umbilical cord mesenchymal stem cells in diabetic kidney disease. World J Stem Cells 2025; 17(11): 113201

"It is a great honor for my article to be published in your esteemed journal. I am extremely grateful for the guidance provided by ..." [Read more]

"It is a great honor for my article to be published in your esteemed journal. I am extremely grateful for the guidance provided by the editors and peer reviewers. The entire publication process was very smooth, and the editors were very patient and professional. I wish your journal continued success. " [Collapse]

Sun ZY, Ye L, Mao YY, Liang L. Effect of enhanced recovery after surgery nursing on gastrointestinal recovery function and life quality in patients laparoscopic cholecystectomy. World J Gastrointest Surg 2025; 17(11): 108188

"Dear Editorial Team Hepatocellular carcinoma is one of the most common cancers worldwide and is often diagnosed at an advanced stage, ..." [Read more]

"Dear Editorial Team Hepatocellular carcinoma is one of the most common cancers worldwide and is often diagnosed at an advanced stage, making accurate recognition and prediction of its biological behavior critically important for clinicians. Having our review on ensemble learning approaches for HCC published in such a distinguished journal is truly gratifying. I hope clinicians and researchers find these insights useful in improving diagnostic accuracy, refining prognostic modeling, and ultimately enhancing patient outcomes through more robust, data-driven decision-making Best regards " [Collapse]

Akbulut S, Colak C. Explainable artificial intelligence and ensemble learning for hepatocellular carcinoma classification: State of the art, performance, and clinical implications. World J Hepatol 2025; 17(11): 109494

"Dear Editorial team Having my work published in such a prestigious and internationally respected journal is truly meaningful for me. ..." [Read more]

"Dear Editorial team Having my work published in such a prestigious and internationally respected journal is truly meaningful for me. I am sincerely pleased to see our efforts recognized at this level, and I genuinely hope that readers will benefit from the insights and contributions presented in this valuable article. Best regards " [Collapse]

Akbulut S, Kucukakcali Z, Colak C. Artificial intelligence in acute appendicitis: A comprehensive review of machine learning and deep learning applications. World J Gastroenterol 2025; 31(43): 112000

"We are happy with the submission. I hope that y the editor can provide us with additional invited papers. We look forward to working ..." [Read more]

"We are happy with the submission. I hope that y the editor can provide us with additional invited papers. We look forward to working with BPG. The reviewing process needs work. It takes numerous months before reviewers are found. The system could be improved by slimlining the entire submission process. Other journals take 1-2 for complete publication. " [Collapse]

Zeppieri M, Musa M, Cordeiro MF, Gagliano C, D’Esposito F. Reevaluating Usher syndrome: Transitioning from traditional subtypes to precision diagnosis. World J Med Genet 2025; 13(1): 112991

"The journal provided an exceptionally thorough and constructive review process. The feedback was clear, insightful, and helped ..." [Read more]

"The journal provided an exceptionally thorough and constructive review process. The feedback was clear, insightful, and helped strengthen the overall quality of the manuscript. The editorial team ensured that the tables were presented with excellent clarity and organization, enhancing the readability of the results. I also appreciated the efficient and transparent publication workflow. Overall, this journal demonstrates professionalism, high academic standards, and a strong commitment to authors. " [Collapse]

Nagesh VK, Martinez E, Badam S, Harrison JL, Basta M, Varughese VJ, Anwar GR, Deshpande V, Francis D, Islek D, Pulipaka SP, Bhuju R, Moliya P, Niazi B, Elias S. Management of acute liver failure-an updated literature review. World J Crit Care Med 2025; 14(4): 108840

"We are very pleased that the manuscript we submitted to World Journal of Clinical Oncology has been accepted and puslided in this ..." [Read more]

"We are very pleased that the manuscript we submitted to World Journal of Clinical Oncology has been accepted and puslided in this prestigious journal. We are grateful to the reviewing process and we have no further comments to submit thank you in advance kind regards. We will submit in the future for our work. " [Collapse]

Seretis F, Panagaki A, Gkolfakis P, Tziatzios G, Paraskeva K. Endoscopic assessment of rectal cancer response after neoadjuvant chemoradiotherapy: A narrative literature review. World J Clin Oncol 2025; 16(11): 106498

"The review process itself was fine, but the submission site/online portal had some issues. There was also clearly come confusion on ..." [Read more]

"The review process itself was fine, but the submission site/online portal had some issues. There was also clearly come confusion on the editor side of things as we kept receiving different decisions and different proofs almost like multiple separate people were handling our submission and not communicating with one another, which directly contributed to how long the entire process took. " [Collapse]

Merhavy ZI, Raeburn T, Torres-Ayala GM, McCulloch MA, Varkey TC. Sedation and analgesia strategies in the neuro intensive care unit. World J Crit Care Med 2025; 14(4): 111787

"We are extremely grateful to the editorial department for allowing our article to be published in such an excellent journal as WJGO. ..." [Read more]

"We are extremely grateful to the editorial department for allowing our article to be published in such an excellent journal as WJGO. We are also grateful to the reviewers for their suggestions in improving the quality of the article. Finally, we are thankful to the editorial department for helping to ensure the smooth publication of our article. " [Collapse]

Yang XM, Sun W, He YG, Peng XH, You N, Tang YC, Zheng L, Huang XB. Patient-derived organoids for the personalized treatment of pancreatic neuroendocrine tumor with liver metastases: A case report. World J Gastrointest Oncol 2025; 17(11): 112385

20123 items Read more >>

Article Quality Tracking-Peer-Review

"This study analyzes RSPO3 rearrangements in advanced colorectal cancer (aCRC) and their clinical implications. Among 73 patients with ..." [Read more]

"This study analyzes RSPO3 rearrangements in advanced colorectal cancer (aCRC) and their clinical implications. Among 73 patients with stage pT4a‑b tumors, RSPO3 fusions were detected in 8% of cases, predominantly in right‑sided or transverse colon cancers. These rearrangements were associated with smaller tumor size, normal carcinoembryonic antigen levels, microsatellite stability, and significantly poorer overall survival. The authors also confirmed through in silico analyses that elevated RSPO3 expression correlates with worse recurrence‑free and overall survival in independent CRC cohorts. Strengths of the work include comprehensive next‑generation sequencing of 50 cancer‑related genes, detailed clonal evolution analysis, and integration of clinical, pathological, and molecular data. Overall, the study highlights RSPO3 fusions as a potential prognostic biomarker and therapeutic target in advanced colorectal cancer." [Collapse]

Tur R, Abad M, Filipovich E, Rivas MB, Rodriguez M, Montero JC, Sayagués JM. RSPO3 rearrangements in advanced colorectal cancer patients and their relationship with disease characteristics. World J Gastrointest Oncol 2025; 17(11): 112838

"This retrospective study develops and validates a novel nomogram model to predict survival outcomes in advanced HER‑2 negative gastric ..." [Read more]

"This retrospective study develops and validates a novel nomogram model to predict survival outcomes in advanced HER‑2 negative gastric cancer patients treated with immunochemotherapy. Using data from 200 patients who received sintilimab plus chemotherapy, the authors identified PD‑L1 expression, microsatellite status, TNM stage, tumor differentiation, neutrophil‑to‑lymphocyte ratio, and the C‑reactive protein–albumin–lymphocyte (CALLY) index as independent prognostic factors. The resulting models demonstrated strong discrimination (C‑index 0.78–0.82) and calibration, with high accuracy for progression‑free and overall survival across multiple time points. Strengths of the work include integration of molecular, clinical, and inflammatory markers into a single predictive tool, rigorous statistical validation, and clear demonstration of clinical applicability. Overall, the study provides a robust framework for individualized risk assessment and treatment planning in HER‑2 negative advanced gastric cancer." [Collapse]

Yao ZY, Bao G, Li GC, Hao QL, Ma LJ, Rao YX, Xu K, Ma X, Han ZX. Survival prognosis in advanced HER-2 negative gastric cancer treated with immunochemotherapy: A novel model. World J Gastrointest Oncol 2025; 17(11): 112981

"This meta‑analysis evaluates the efficacy of neoadjuvant immunotherapy combined with radiotherapy and chemotherapy in locally advanced ..." [Read more]

"This meta‑analysis evaluates the efficacy of neoadjuvant immunotherapy combined with radiotherapy and chemotherapy in locally advanced rectal cancer (LARC). Across 15 studies involving 796 patients, the addition of immunotherapy significantly improved major pathological response, pathological complete response, and clinical complete response, particularly in patients with proficient mismatch repair (pMMR) and microsatellite stability. Rates of R0 resection and sphincter‑preserving surgery were also higher, while adverse events such as hematologic toxicity and liver dysfunction remained within acceptable limits. Strengths of the study include comprehensive literature retrieval, rigorous subgroup and sensitivity analyses, and clear reporting of heterogeneity and publication bias. Overall, the findings suggest that integrating immunotherapy into neoadjuvant chemoradiotherapy regimens enhances remission and organ preservation without substantially increasing complications, supporting its consideration as a first‑line strategy for LARC." [Collapse]

Yan WX, Yuan HQ, Xiong ZY, Qin LJ, Wu J, He J, Mu J, Li J, Li N. Meta-analysis of the efficacy of neoadjuvant immunotherapy combined with radiotherapy and chemotherapy for locally advanced rectal cancer. World J Gastrointest Oncol 2025; 17(11): 113048

"This study investigates folate receptor–positive circulating tumor cells (FR+ CTCs) as potential biomarkers for hepatocellular ..." [Read more]

"This study investigates folate receptor–positive circulating tumor cells (FR+ CTCs) as potential biomarkers for hepatocellular carcinoma (HCC). In a retrospective cohort of 128 patients, FR+ CTC counts demonstrated superior diagnostic accuracy compared to alpha‑fetoprotein (AFP), with sensitivity of 90% and specificity of 77%. Elevated FR+ CTC levels correlated with adverse pathological features such as larger tumor size, multiple lesions, macrovascular invasion, and extrahepatic metastasis. Importantly, higher baseline FR+ CTC counts predicted shorter disease‑free survival after hepatectomy, with a cutoff of 12.9 FU/3 mL distinguishing high‑risk patients. Strengths of the work include rigorous methodology using ligand‑target PCR, clear statistical validation with ROC and Cox regression analyses, and demonstration that FR+ CTCs may serve both diagnostic and prognostic roles independent of AFP. These findings provide promising evidence that FR+ CTC quantification could enhance patient stratification, guide treatment evaluation, and improve recurrence prediction in HCC." [Collapse]

Zhang ZY, Zhou M, Liu JJ, Zhang W. Folate receptor-positive circulating tumor cells might function as potential biomarkers for hepatocellular carcinoma. World J Gastrointest Oncol 2025; 17(11): 113431

"This article presents two rare case reports of gastrointestinal stromal tumors (GISTs) driven by novel FGFR2 fusions, expanding the ..." [Read more]

"This article presents two rare case reports of gastrointestinal stromal tumors (GISTs) driven by novel FGFR2 fusions, expanding the molecular spectrum beyond the well‑known KIT and PDGFRA mutations. Both patients underwent successful surgical resection followed by adjuvant imatinib therapy, achieving sustained remission over more than two years. The study is well executed in several respects: it highlights the importance of comprehensive genomic profiling with next‑generation sequencing to uncover actionable mutations, demonstrates that even non‑canonical alterations may respond to standard tyrosine kinase inhibitors, and underscores the potential of FGFR‑targeted therapies for imatinib‑resistant or advanced disease. By carefully documenting clinical, pathological, and molecular features, the authors provide valuable preliminary evidence that FGFR2 fusions may define a distinct, therapeutically relevant GIST subtype." [Collapse]

Hong YY, Shou CH, Yang WL, Wang XD, Zhang Q, Liu XS, Yu JR. FGFR2 fusions as novel oncogenic drivers in gastrointestinal stromal tumors: Two case reports and review of literature. World J Gastrointest Oncol 2025; 17(11): 113262

"I read with interest of this article. In spite of there are many similar studies in literature, the findings of this study is still ..." [Read more]

"I read with interest of this article. In spite of there are many similar studies in literature, the findings of this study is still informative. Shear wave elastography (SWE) is a non-invasive ultrasound (US) technique that can quantify tissue stiffness, which can used for assistance of diagnosing focal and diffusive diseases. Establishing reference values in normal tissues or organs in healthy individuals is crucial, since abnormal stiffness is associated with clinically relevant conditions such as tumors, liver fibrosis, and pancreatic disease. In the literature, normal values of stiffness for liver, spleen, and pancreas in healthy individuals are various, and they have not been well established. In this study, the investigators measured the stiffness of the liver, spleen, and pancreas in 50 healthy subjects with p-QElaXto and 2D-QElaXto on Esaote MyLab 9 ultrasound system, compared with 2D-SWE on the SuperSonic Imagine Aixplorer (SSI). Values of measurements of stiffness ranges were analyzed for relationship with clinical and technical factors, and inter-operator variability across the different SWE modalities were studied. The results demonstrated that the liver and spleen stiffness assessment was feasible in > 98% of patients, while pancreas stiffness was measurable in 84%-88% depending on the SWE technique. Mean liver stiffness ranged between 3.9-4.7 kPa across techniques, spleen stiffness ranged from 19.4-23.0 kPa, and pancreas stiffness from 5.2-7.6 kPa. Inter-operator agreement was excellent for liver and good to moderate for spleen and pancreas. Bland-Altman analysis confirmed good correlation but also systematic differences among devices, especially in pancreas measurements. The investigators concluded that the values of stiffness of the liver and spleen matched existing guidelines, and pancreas SWE showed more variability and reduced reproducibility. Stiffness measurements of the pancreatic using shear wave elastography is less reliable than that for liver and spleen. There were some potential limitations of this study, as had been addressed in the article, especially the relatively small sample size compromises the soundness and robust of the results. " [Collapse]

Viceconti N, Paratore M, Del Zompo F, Zocco MA, Ainora ME, Esposto G, Gasbarrini A, Pompili M, Riccardi L, Garcovich M. Shear wave elastography in healthy patients: Pancreatic stiffness is less reliable than liver and spleen measurements. World J Radiol 2025; 17(11): 111651

"This review was well written. The subject was meaningful. The objective of this study was to analyse the utility of point-of-care ..." [Read more]

"This review was well written. The subject was meaningful. The objective of this study was to analyse the utility of point-of-care ultrasound-measured optic nerve sheath diameter for early identification of raised intracranial pressure in non-traumatic headache patients, aiming to guide clinicians in integrating this technique into early headache evaluation for better patient outcomes. Point-of-care ultrasound measurement of optic nerve sheath diameter is a convenient, non-invasive method with high sensitivity and specificity for detecting elevated intracranial pressure. Its use can expedite diagnosis, guide urgent management, and reduce unnecessary imaging, especially in outpatient and resource-limited settings. To ensure reliability and accuracy of measurement, comprehensive training programs and standardized protocols for ultrasound operator are required. Emerging artificial intelligence(AI)-assisted measurement promises to enhance its reliability by reducing operator-dependent variability, and this will broaden its clinical impact. AI-assisted interpretation and automated measurement tools will be the future direction. One thing must mention, the word “decline” in the sentence that “A good example of the potential value of POCUS is a patient with an acute neurological decline” should be “deficit”." [Collapse]

Tlaiss Y, Tarchichi A, Atallah K, Al Mashtoub E, Zalzali I, Chokor Z, Fassih I, Harb N, Kassas J, Hamze H. Point-of-care ultrasonography for detecting raised intracranial pressure through optic nerve sheath diameter in non-traumatic headache patients. World J Radiol 2025; 17(11): 113012

"In patients with troponin elevation at ER, distinguishing ACS is crucial, but troponin often rises for reasons other than ACS. PSVT ..." [Read more]

"In patients with troponin elevation at ER, distinguishing ACS is crucial, but troponin often rises for reasons other than ACS. PSVT is one such cause, but diagnosis is difficult if the episode has already terminated by the time the ER ECG is taken. This is because troponin is only positive in 30-50% of PSVT cases. Even if sinus rhythm is present at presentation, troponin may still be positive after PSVT has stopped. For example, in patients who experienced palpitations. Therefore, I would also like to see criteria indicating in which PSVT cases troponin will be positive. Elevated troponin due to paroxysmal supraventricular tachycardia (PSVT) does not merely indicate the presence of ischemic heart disease. It is associated with a high heart rate, prolonged duration, chest pain, and in many cases, causes mild to moderate transient troponin elevation. Conversely, in the absence of obvious organic heart disease, it does not directly correlate with worsened clinical prognosis. The degree of troponin elevation is primarily associated with the heart rate during the episode (risk increases at 165 bpm or higher) and the duration of the episode. Particularly in clinically stable cases, there appears to be limited justification for invasive evaluation based solely on troponin elevation. Further validation through large-scale prospective studies is desired in the future. " [Collapse]

Özlek B, Tanık VO, Barutçu S. Troponin elevation in supraventricular tachycardia: A narrative review. World J Cardiol 2025; 17(11): 113411

"Lymphangiomas occur in various parts of the body, most commonly in the head and neck region, but rarely in the gastrointestinal tract. ..." [Read more]

"Lymphangiomas occur in various parts of the body, most commonly in the head and neck region, but rarely in the gastrointestinal tract. Esophageal lymphangioma is an exceedingly rare benign submucosal tumor. Lymphangiomas are usually asymptomatic and incidentally found on endoscopic evaluation. This is a well- written and presented rarely case report. This manuscript gives additional new knowledge to the existing literature. Ithink that this manuscript is worth to publication." [Collapse]

Zheng XL, Yu XX. Esophageal lymphangioma: A case report and review of literature. World J Gastrointest Surg 2025; 17(11): 111148

"This study proposes that the tumor-suppressive functions of these proteases are contingent upon the stage of cancer progression or ..." [Read more]

"This study proposes that the tumor-suppressive functions of these proteases are contingent upon the stage of cancer progression or metastatic conditions, and may be activated or suppressed in response to cues from the tumor microenvironment. The proposition that the functional role of tumors—either promoting or inhibiting cancer—can be dynamically regulated by the tumor microenvironment is a noteworthy conceptual advancement. Indeed, cancer is increasingly recognized as a complex pathological ecosystem. Within this framework, genes and mutations are not primary causal drivers of carcinogenesis—as posited by the prevailing somatic mutation theory—but rather represent one of many events occurring throughout tumor evolution. A more comprehensive understanding therefore requires the integration of genetic and mutational dynamics within broader ecological and evolutionary contexts (https://pubmed.ncbi.nlm.nih.gov/40443342/)." [Collapse]

Palacios Serrato EG, Medina-Abreu KH, Oropeza-Martínez E, Jacinto-Alemán LF, Macías-Silva M, Tecalco-Cruz AC. ADAMTS-8 and kallikrein-related peptidases 10 and 5 proteases also have a tumor suppression role. World J Clin Oncol 2025; 16(11): 110202

"• This is very interesting paper about pancreatic cyst. Pancreatic cysts are diagnosed through imaging tests like CT, MRI, and ..." [Read more]

"• This is very interesting paper about pancreatic cyst. Pancreatic cysts are diagnosed through imaging tests like CT, MRI, and endoscopic ultrasound (EUS). These tests help characterize the cyst's size, structure, and relationship to the pancreas. An EUS can also be used to collect fluid or tissue samples for lab analysis to check for cancer cells, while other factors like symptoms, patient history, and risk factors are also considered to make a final diagnosis. Fluid and tissue analysis: If a sample is collected through EUS-FNA, the fluid is analyzed for specific markers like carcinoembryonic antigen (CEA), which can help identify cancer. The diagnostic process involves a combination of medical history review, various imaging tests, and sometimes fluid analysis/biopsy to determine the cyst's type and its potential for malignancy. " [Collapse]

Shumka N, Karagyozov PI. Cystic tumors of the pancreas: Current perspectives on diagnosis and management. World J Gastroenterol 2025; 31(43): 111393

"The article is well written and well conducted. I particularly appreciated the discussion, which is rich and full of interesting ..." [Read more]

"The article is well written and well conducted. I particularly appreciated the discussion, which is rich and full of interesting comments. Unfortunately, the study is retrospective. The addition of other parameters, such as the precence of left ventricular noncompaction and serum electrolyte values, would likely have further differentiated the two populations studied." [Collapse]

Kaddoura R, Al-Tamimi H, Pieles GE. Racial disparities in electrical and structural cardiac adaptation among adolescent athletes: A systematic review and meta-analysis. World J Cardiol 2025; 17(11): 107835

" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..." [Read more]

" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied." [Collapse]

Park YE. Gastric Crohn’s disease presenting as a subepithelial tumor: A case report. World J Clin Cases 2025; 13(33): 113312

" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..." [Read more]

Bergeron E, Gologan A. Abdominal compartment syndrome with colonic hypoganglionosis and massive colonic distension in a young adult: A case report. World J Clin Cases 2025; 13(33): 112684

"1. Ethics It is a review article thus ethics approval form is not required 2. Methods As a narrative/invited review, the “methods” ..." [Read more]

"1. Ethics It is a review article thus ethics approval form is not required 2. Methods As a narrative/invited review, the “methods” section is not a detailed primary experimental protocol. The paper describes construction methods of gastric organoids, modeling steps, mechanisms, limitations and future directions. The methods are adequate in describing the topic and background rather than reporting new experimental workflows. 3. Results The results are summary of published work rather than original data. The authors summaries how gastric organoids can model atrophic gastritis → intestinal metaplasia → dysplasia → gastric cancer, and discuss mechanisms and propose that gastric organoids are a “promising model” for the inflammation-cancer transition. 4. Figures and Tables Figures shows the multiple schematic figures. Annotation/Quality of the figures is good and are schematic exhibiting the appropriateness for this study. The legends appear clear; axes/labels in the schematics are present. The paper has well-constructed and expressive figures and tables. 5. Biostatistics This is a review paper, there is no new statistical analyses/biostatistical tables of primary data are needed. 6. References Lis of references is current, appropriate and is reasonable in number (> 100) 7. Language The language is clear, rationally concise, and generally well-written. " [Collapse]

Liu C, Wu CH, Jia YB, Qiu JX, Li XY, Ling JH. Gastric organoids: A promising model for studying “inflammation-cancer” transition in atrophic gastritis. World J Clin Oncol 2025; 16(11): 110453

"It was with pleasure that I tracked the article quality of the following manuscript. Please see my comments below: 1 Ethics: Not ..." [Read more]

"It was with pleasure that I tracked the article quality of the following manuscript. Please see my comments below: 1 Ethics: Not applicable given manuscript type 2 Methods: Not applicable given manuscript type 3 Results: Not applicable given manuscript type 4 Figures and tables: The figures add to the readability of the manuscript 5 Biostatistics: Not applicable given manuscript type 6 References: The references are appropriate/up-to-date 7 Language: This is a concise/well written editorial 8 Caveats or drawbacks: N/A " [Collapse]

Zerem E, Zerem D, Vila Š, Bajgorić S. Ascites in acute pancreatitis: A window into disease severity. World J Gastroenterol 2025; 31(43): 112797

"“Pyroptosis” is a term composed of the union of two separate ancient Greek words, namely “Πυρ” (Fire) and “Πτώσις” (fall), which ..." [Read more]

"“Pyroptosis” is a term composed of the union of two separate ancient Greek words, namely “Πυρ” (Fire) and “Πτώσις” (fall), which together mean “fall of the fire” (reduction of inflammation). It is a lytic mechanism of programmed cell death that involves cleavage of proteins in the gasdermin D family. Its effects are mediated through nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3)/caspase-1 classical and caspase-4/5/11. The inflammatory process mediated by this mechanism appears to play a central role in the development and pathogenesis of IBD by destroying the intestinal epithelial barrier, leading to excessive inflammation and worsening the disease progression. Targeting pyroptosis is a promising therapeutic approach for IBD. Recent data support the notion that inhibitors of inflammasomes, such as small-molecule biological agents, other biological agents, and drugs that specifically target NLRP3, caspases, or GSDMD, suppress inflammasome activation and inhibit membrane pore formation. However, the precise regulatory mechanisms and therapeutic effect of pharmacological targeting of inflammasomes in IBD are not fully understood. Research on the specificity of pharmaceutical agents that may prove effective in treating the disease, the extent of drug side effects, and the potential for combination with other active pharmaceutical agents is a key goal for the near future. " [Collapse]

Dong WW, Liu T, He LX, He WT. Targeting pyroptosis in inflammatory bowel disease: A potentially effective therapeutic approach. World J Gastroenterol 2025; 31(43): 111358

"This letter to the Editor just agrees with the authors of the original paper that BMI is associated with worse outcome in patients ..." [Read more]

"This letter to the Editor just agrees with the authors of the original paper that BMI is associated with worse outcome in patients with acute liver injury. In this regard, all "scientific" information descries only "associations" with BMI and organ failure. However no studies indicate possible causes so science can advance towards possible treatments beyond weight loss." [Collapse]

Kanda T, Sasaki-Tanaka R, Kamimura H, Terai S. Is higher body mass index correlated with worse clinical outcomes in acute liver failure? World J Clin Cases 2025; 13(32): 113514

"A concise, comprehensive, complex and well-structured manuscript. There are no grammatical/spelling errors throughout the manuscript ..." [Read more]

"A concise, comprehensive, complex and well-structured manuscript. There are no grammatical/spelling errors throughout the manuscript and the topic debated is of a great interest due to the fact that AI technologies have a real potential to revolutionize liver lesion assessment in association with CEUS. Indeed, in order to obtain a valid implementation in clinical practice of AI technologies combined with CEUS, we need more large-scale prospective studies in the near future. " [Collapse]

Ciocalteu A, Urhut CM, Streba CT, Kamal A, Mamuleanu M, Sandulescu LD. Artificial intelligence in contrast enhanced ultrasound: A new era for liver lesion assessment. World J Gastroenterol 2025; 31(42): 112196

"1 Ethics: Not provided 2 Methods: The experimental method is effective and can be repeated by fellow researchers 3 Results ..." [Read more]

"1 Ethics: Not provided 2 Methods: The experimental method is effective and can be repeated by fellow researchers 3 Results The theory is validated 4 No figures or tables provided 5 Biostatistics: Not needed 6 References: The author scientifically and reasonably cite the latest references 7 Language: The language in article correctly, clearly and concisely expresses the information " [Collapse]

Sameer M, Muthu S, Vadranapu S. Prophylactic fixation in elderly fractures: Preventive breakthrough or unnecessary intervention? World J Orthop 2025; 16(11): 109855

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Peer-Reviewers and Manuscript Statistics

Editorial board members: 2264

Peer-reviewers: 34938

Manuscripts received today: 11

Manuscript reviews today: 23

Unhandled manuscripts today: 146

Active peer-reviewers today: 1985

Reviewer acceptance today: 34

Reviewer refusals today: 37

Total accepted manuscripts: 38920

Total rejected manuscripts: 43893

Total peer-reviewers: 4541603

Total submissions: 36953