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596 items Read more >>
1
"We sincerely thank you for the opportunity to have our article published in your magazine. We are also sincerely grateful to the ..."
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"We sincerely thank you for the opportunity to have our article published in your magazine. We are also sincerely grateful to the editorial team and the anonymous reviewers for their meticulous evaluation and constructive feedback. These professional suggestions have significantly enhanced the scientific rigor and presentation quality of our research work. We have no comments. "
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Yang HC, Qu W. Diagnostic and therapeutic review of a rare gastric inflammatory fibroid polyps case with distinctive features: A case report. World J Gastrointest Endosc 2025; 17(5): 106074
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"I am highly satisfied with the overall editorial and publication process provided by this journal. From the efficiency of the online ..."
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"I am highly satisfied with the overall editorial and publication process provided by this journal. From the efficiency of the online submission system to the professionalism of the peer review and editorial teams, each stage of the process was conducted with clarity, transparency, and academic rigor. The peer review reports were constructive, fair, and instrumental in enhancing the quality of my manuscript. Moreover, the quality of the final published articleת, including figures, tables, and formatting, met high academic standards. The publication timeline was reasonable, and the journal’s adherence to ethical norms and academic integrity was evident throughout. My co-author and I also greatly appreciate the invitation to publish our work in this esteemed journal. I commend the journal for maintaining a high standard of scholarly communication and would gladly consider it for future submissions. "
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Yaffe Y, Levkovich I. Prolonged grief disorder in bereaved parents: Exploring impacts and treatment pathways. World J Psychiatry 2025; 15(5): 104711
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"This review examines the correlations between multimodal diagnostic modalities and pathological findings in Crohn's disease, critically ..."
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"This review examines the correlations between multimodal diagnostic modalities and pathological findings in Crohn's disease, critically analyzing the strengths and limitations of each approach. The discussion provides valuable insights for both clinical practice and research.The submission and publication process of this manuscript has been a gratifying experience that has significantly enhanced our research competencies and broadened our academic perspectives. We intend to continue actively contributing to and sharing academic work through your esteemed journal in the future. "
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Fang HM. Intricacy of Crohn’s disease: Incongruity between diagnostic modalities and histopathologic assessment. World J Gastrointest Endosc 2025; 17(4): 103979
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"I am extremely pleased with my entire experience during the manuscript submission and review journey. The online submission platform ..."
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"I am extremely pleased with my entire experience during the manuscript submission and review journey. The online submission platform was user - friendly and highly efficient. Its intuitive design allowed me to submit my manuscript with ease, eliminating any potential complications or confusion. The peer - review report I received was comprehensive and constructive. The reviewers provided in - depth analysis and offered a wealth of valuable suggestions. These insights were instrumental in enhancing the quality of my manuscript, helping me to strengthen its arguments, improve the clarity of my research, and address any potential gaps or weaknesses. The editing of the article was of the highest caliber. The editors' work was clear, professional, and meticulous. Their revisions significantly enhanced the readability and overall presentation of the manuscript. They paid attention to grammar, style, and formatting, ensuring that the final version of the article was polished and ready for publication. The publication process was seamless and timely. Every step was carried out efficiently, and I was impressed by how strictly the journal adhered to academic rules and norms. This commitment to academic integrity was evident from the start to the end of the process. Additionally, the academic misconduct detection report was a reassuring feature. It demonstrated the journal's dedication to maintaining high - quality publishing standards and added credibility to its publishing practices, giving me confidence that my work was in good hands. "
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Zhang JW. Genetic intersection of human leukocyte antigen-DP/DQ and hepatitis B virus-related liver disease: Insights from a multi-clustering study. World J Gastroenterol 2025; 31(16): 102511
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"Authors are thankful to the editorial team of WJEM for the consideration of our review article. Submission to publication, the process ..."
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"Authors are thankful to the editorial team of WJEM for the consideration of our review article. Submission to publication, the process were cool enough and very much easy friendly. Evaluation was very fair. Editors comments really help us in improvising the scientific quality of the work. Every one other queries' raised were very much helpful in revising the script. "
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Sainath PB, Ramaiyan V. Weak D phenotype in transfusion medicine and obstetrics: Challenges and opportunities. World J Exp Med 2025; 15(2): 102345
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"We are quite satisfied with the entire submission process, and it would be better if it were simplified. Especially grateful for the ..."
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"We are quite satisfied with the entire submission process, and it would be better if it were simplified. Especially grateful for the valuable opinions provided by the external review experts and the editor's handling of the manuscript. If the processing cycle for manuscripts could be shortened further, it would be even more ideal. "
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Liang W, Wang L, Song M, Geng H, Jing XY, Li W, Huo YX, Huang AQ, Wang XY, An CX. Correlation between mild behavioral impairment and peripheral blood biomarkers in patients with mild cognitive impairment. World J Psychiatry 2025; 15(5): 103256
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"A very rigorous journal with a smooth submission process, diligent and responsible editors, and high requirements for manuscript ..."
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"A very rigorous journal with a smooth submission process, diligent and responsible editors, and high requirements for manuscript quality. The opinions and suggestions of the reviewers and editors are very helpful in improving the quality of our manuscript. We are very satisfied with this submission and publication of the manuscript. "
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Liang ZF, Xu YM, Song JJ, Gao ZH, Qian H, Xu XZ. Interventional effect of hesperetin on N-methyl-N’-nitro-N-nitrosoguanidine-induced exosomal circ008274 in affecting normal cells to promote gastric carcinogenesis. World J Gastroenterol 2025; 31(16): 104920
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"The journal's editorial team demonstrated exceptional professionalism through meticulous manuscript evaluation, prompt communication ..."
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"The journal's editorial team demonstrated exceptional professionalism through meticulous manuscript evaluation, prompt communication at every revision stage, and adherence to rigorous publication timelines, ensuring both scholarly rigour and operational efficiency. From transparent peer-review coordination to seamless production workflows, the publishing service maintained exemplary standards in technical precision and cross-departmental collaboration, reflecting a commitment to high-quality academic dissemination. "
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Zhang H, Zhang M, Li N, Wei WZ, Yang LX, Li YY, Zu ZY, Ma LJ, Wang HX, Wang K, Li XM. Event-related potentials reveal hypnotherapy's impact on attention bias in social anxiety disorder. World J Psychiatry 2025; 15(5): 102552
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"Our experience with this journal was highly positive overall. The editorial team handled our submission efficiently, with clear ..."
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"Our experience with this journal was highly positive overall. The editorial team handled our submission efficiently, with clear communication at each stage. Peer reviewers provided insightful, field specific critiques that enhanced the manuscript's rigor.The submission portal streamlined revisions effectively. We recommend this journal for its rigorous yet supportive scholarly environment. "
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He T, He X, Yuan XM. High-output heart failure secondary to iatrogenic arteriovenous fistula: A case report. World J Cardiol 2025; 17(4): 104748
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"I am very grateful for the opportunity to have our manuscript published in this journal, and I am very grateful to the editors and ..."
[Read more]
"I am very grateful for the opportunity to have our manuscript published in this journal, and I am very grateful to the editors and reviewers for their efforts in reviewing this manuscript. The manuscript was evaluated very fairly, and the quality of our manuscript has improved with each revision. In addition, the editors expedited the processing of this manuscript. I hope to continue submitting manuscripts to this journal in the future. Once again, I would like to thank the editors and reviewers for their handling of this manuscript. Best regards, "
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Byeon H. Impact of night sentry duties on cardiometabolic health in military personnel. World J Cardiol 2025; 17(4): 102133
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"I am very grateful for the opportunity to have our manuscript published in this journal, and I am very grateful to the editors and ..."
[Read more]
"I am very grateful for the opportunity to have our manuscript published in this journal, and I am very grateful to the editors and reviewers for their efforts in reviewing this manuscript. The manuscript was evaluated very fairly, and the quality of our manuscript has improved with each revision. In addition, the editors expedited the processing of this manuscript. I hope to continue submitting manuscripts to this journal in the future. Once again, I would like to thank the editors and reviewers for their handling of this manuscript. Best regards, "
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Byeon H. Unveiling the invisible: How cutting-edge neuroimaging transforms adolescent depression diagnosis. World J Psychiatry 2025; 15(5): 102953
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"I am very grateful for the opportunity to have our manuscript published in this journal, and I am very grateful to the editors and ..."
[Read more]
"I am very grateful for the opportunity to have our manuscript published in this journal, and I am very grateful to the editors and reviewers for their efforts in reviewing this manuscript. The manuscript was evaluated very fairly, and the quality of our manuscript has improved with each revision. In addition, the editors expedited the processing of this manuscript. I hope to continue submitting manuscripts to this journal in the future. Once again, I would like to thank the editors and reviewers for their handling of this manuscript. Best regards, "
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Akpoveta ED, Okpete UE, Byeon H. Personalized therapeutic approaches for improved glycemic outcomes in type 2 diabetes. World J Diabetes 2025; 16(5): 104841
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"The rigorous and patient review work provided by the journal's editors and reviewers enhanced the reliability of the findings and ..."
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"The rigorous and patient review work provided by the journal's editors and reviewers enhanced the reliability of the findings and provided valuable learning opportunities for project members. In addition, the journal's review process is complete and fast, and the publication work is professional and detailed. We are grateful to the editors and reviewers of the World Journal of Diabetes for their work. "
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Chen AM, He QY, Wu YC, Chen JQ, Ma XQ, Hu LY, Wang GNY, Wang ZT, Wu ZY, Zheng ZJ, Jia YJ. Association of quantified cardiovascular health status with all-cause mortality risk in prediabetic patients. World J Diabetes 2025; 16(5): 102052
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"Good work, the submission process, peer review, time from submission to publication is adequate. good editing process, good feed back, ..."
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"Good work, the submission process, peer review, time from submission to publication is adequate. good editing process, good feed back, quality of the published figures and tables. No bias detected, good professionalism when dealing with the editor. Happy to consider submitting more papers in the future to the journal for consideration for possible publication. "
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M Behrens KM, Elgafy H. Factors affecting outcomes of indirect decompression after oblique and lateral lumbar interbody fusions. World J Orthop 2025; 16(3): 100772
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"Good work, the submission process, peer review, time from submission to publication is adequate. good editing process, good feed back, ..."
[Read more]
"Good work, the submission process, peer review, time from submission to publication is adequate. good editing process, good feed back, quality of the published figures and tables. No bias detected, good professionalism when dealing with the editor. Happy to consider submitting more papers in the future to the journal for consideration for possible publication. "
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Elgafy H, Peters N, Lea JE, Wetzel RM. Hemorrhagic lumbar synovial facet cyst secondary to transforaminal epidural injection: A case report and review of the literature. World J Orthop 2016; 7(7): 452-457
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"We sincerely appreciate the efficient and professional work of the World Journal of Clinical Cases editorial team, as well as the ..."
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"We sincerely appreciate the efficient and professional work of the World Journal of Clinical Cases editorial team, as well as the valuable feedback from the peer reviewers. Your rigorous evaluation and constructive suggestions significantly improved our manuscript. We also thank the publisher for this excellent platform, which enables the dissemination of our research. It is truly an honor to collaborate with such an outstanding team, and we look forward to future opportunities to advance academic excellence together. "
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Zhou XY, Jiang YJ, Guo XM, Han DH, Liu Y, Qiao Q. Application of circulating tumor DNA liquid biopsy in nasopharyngeal carcinoma: A case report and review of literature. World J Clin Cases 2025; 13(21): 105066
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"I would like to express my gratitude for accepting the publication of my paper. I am very satisfied with and appreciative of the entire ..."
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"I would like to express my gratitude for accepting the publication of my paper. I am very satisfied with and appreciative of the entire editorial process. I would like to express my gratitude for your work.I wish your company continued success and growth.I look forward to submitting my new manuscript to your esteemed journal. "
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Tanaka T, Yoshii Y. Sixteen patients regarding the conservative treatment for hook of hamate fracture. World J Orthop 2025; 16(4): 103795
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"The experience publishing in the journal World Journal of Clinical Case of the BPG group has been very good, for all members of our ..."
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"The experience publishing in the journal World Journal of Clinical Case of the BPG group has been very good, for all members of our team, in all aspects, such as comments from the reviewers, comments from the editors, speed of all the procedures, online submission system, editing quality of the article, pdf of the article, etc "
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Lorente L, Hernández Marrero E, Abreu-Gonzalez P, Lorente Martín AD, González-Rivero AF, Marrero González MJ, Hernández Marrero C, Hernández Marrero O, Jiménez A, Hernández Padilla CM. Low salivary uric acid levels are independently associated with periodontitis. World J Clin Cases 2025; 13(21): 105911
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"the submission process was very smooth and the quality of the article editing was also very high. the editing and publishing rules ..."
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"the submission process was very smooth and the quality of the article editing was also very high. the editing and publishing rules and norms are very friendly. I agree with the review and evaluation of the article. The review and editing of the journal are very objective and have been of great help to me "
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Song ZY, Li N, Liu HB. Analysis of influencing factors on the nutritional status of non-dialysis elderly patients with chronic kidney disease and depression. World J Psychiatry 2025; 15(5): 102539
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"World Psychiatry is a good journal related to the psychiatric profession，we have high expectations for it and the review process is ..."
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"World Psychiatry is a good journal related to the psychiatric profession，we have high expectations for it and the review process is very rigorous。Its a very happy experience to receive the accept email，and thanks for all editors. In the future, I hope the magazine gets better and better and more articles get published! "
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Sun B, Li C, Zhang CL, Li JH, Mao M, Wang G, Zhang ZF. Meta-analysis of the effects of multimodal physical therapy on improving depression. World J Psychiatry 2025; 15(5): 103937
18607 items Read more >>
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"The authors conducted a systematic review and meta-analysis to compare the clinical outcomes and safety of TAVR and SAVR in patients ..."
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"The authors conducted a systematic review and meta-analysis to compare the clinical outcomes and safety of TAVR and SAVR in patients with severe AS. The methodology follows PRISMA guidelines, and both inclusion criteria and outcome assessment are clearly defined and presented. Multiple reviewers were involved in data extraction procedure eliminating the risk of selection bias. The authors used the Cochrane Collaboration Tool for assessing the risk of bias in the included studies. However, there are concerns regarding the blinding of participants in some studies which could have led to performance bias.
Statistical methods were appropriately applied making the study reproducible by other researchers. TAVR was associated with significantly lower risk of short-term mortality (1-year-mortality) and reduced complications like AKI, major bleeding and new-onset AF, while it was associated with higher rates of long-term mortality (5-year-mortality), permanent pacemaker implantation and major vascular complications compared to SAVR. The results are strongly supported by tables and forest plots. However, the interpretation of this difference in long-term and short-term mortality rates could be discussed further and explain possible factors. The statistical analysis was conducted using Review Manager which is a well-established software in the field.
References are current and relevant including major clinical trials and systematic reviews. The authors avoid excessive self-citation and provide a solid foundation of current literature. The language used in this manuscript is generally clear but some sentences are overly complex and could be simplified for better understanding. This study has several limitations which are appropriately presented and discussed in the relevant section of this manuscript. However, a major caveat regarding this study is that the analysis did not include several patient-specific factors which could have influenced both selection of treatment and outcomes.
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Moradi I, Mustafa MS, Sardar Sheikh J, Shojai Rahnama B, Fredericks M, Kumar Yennam A, Arain M, Saha U, Richard Ma A, Nagendran A, Bin Omer M, Armaghan M, Jaimes DCC, Avinash Bojanki NLSV, Shafique MA. Comparative effectiveness of transcatheter vs surgical aortic valve replacement: A systematic review and meta-analysis. World J Cardiol 2025; 17(4): 104168
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"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..."
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"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Chen LQ, Wu CY, Wu SJ, Ye K. Laparoscopic surgical approaches for various locations of gastrointestinal stromal tumours. World J Clin Cases 2025; 13(21): 105559
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"In this editorial, the authors discussed an article reporting the significance of the triglyceride-glucose (TyG) index in predicting ..."
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"In this editorial, the authors discussed an article reporting the significance of the triglyceride-glucose (TyG) index in predicting prognosis and response to immunotherapy. Unfortunately, it is difficult to assess the study’s significance, as the editorial does not provide actual probability for each comparison. Furthermore, the manuscript lacks clarity, as it contains numerous contradictory statements.
In the sections titled “The TyG Index as a Prognostic Factor in GC” and “Exploring the Relationship Between TyG and Immunotherapy Response”, the authors emphasize that a higher TyG index is associated with better outcomes and an improved response to immunotherapy. However, in the subsequent section “Mechanisms Linking TyG to Cancer Progression and Immune Function”, they state that a high TyG index may promote tumor cell proliferation, inhibit apoptosis, and reduce the response rate to immunotherapy.
The authors should revise the manuscript to resolve these inconsistencies and improve overall clarity."
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Zhao CF, Liu XL, Wu NB, Xu ZF. Triglyceride-glucose index as a prognostic indicator in advanced gastric cancer: Insights and future research. World J Gastroenterol 2025; 31(17): 104794
4
"Helicobacter pylori is still a significant health problem in developed and developing countries. Its presence is associated with ..."
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"Helicobacter pylori is still a significant health problem in developed and developing countries. Its presence is associated with several important consequences. Its eradication is, therefore, an essential objective in cases where its presence has been demonstrated. It is well known that inhibiting gastric acid secretion is necessary for the combination of antibiotics used for its eradication to be effective. In recent years, a new drug with a strong antisecretory effect has been introduced into our pharmaceutical quiver, Vonoprazan (VPZ), which is a member of the potassium competitive acid blockers. In the commented study (Ozercan M et al., Vonoprazan and proton pump inhibitors: which is superior for Helicobacter pylori eradication? World J Gastroenterol 2025; 31(17): 103156), the authors commented on the safety and efficacy of VPZ with the safety and effectiveness of proton pump inhibitors (PPIs), in the eradication of Helicobacter pylori. By reviewing the relevant studies, they found that VPZ administration had a higher rate of efficacy and a lower rate of side effects compared to PPIs. They concluded that despite its higher cost, VPZ is an economically and medically superior therapeutic strategy compared to PPIs. Helicobacter pylori eradication therapy may be a significant problem in daily clinical practice in some proportion of patients, particularly in patients over 60 years of age, for whom the avoidance of the side effects of treatment should be a key objective. This task could be achieved by using fewer antibiotics combined with VPZ, e.g. only amoxicillin plus VPZ which is an important alternative therapy shortly.
The paper by Ozercan M et al. is a comprehensive but clear review of the data on the usefulness of VPZ in the treatment of Helicobacter pylori infection, providing clear guidelines for the use of the drug in daily clinical practice. "
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Ozercan M, Tawheed A, Ismail A, Amer MS, El-Kassas M. Vonoprazan and proton pump inhibitors: Which is superior for Helicobacter pylori eradication? World J Gastroenterol 2025; 31(17): 103156
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"This is the first United Kingdom study to report the frequency of death in patients presenting with paracetamol overdose-related acute ..."
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"This is the first United Kingdom study to report the frequency of death in patients presenting with paracetamol overdose-related acute hepatic failure.Paracetamol overdose (POD) is the most common cause of acute hepatic failure (AHF) in the United Kingdom. Without urgent orthotopic liver transplant (OLT), mortality is high. Indeed, Paracetamol overdose (POD) is the most common cause of acute hepatic failure (AHF) in the United Kingdom. Without urgent orthotopic liver transplant (OLT), mortality is high.
This is an 18-year single-centre retrospective cohort study based in a national liver transplant centre. 524 participants were identified from a departmental database and included if they had AHF from suspected POD and received a psychiatric assessment for OLT.Among 524 patients undergoing psychiatric assessment for OLT, there were 102 in-episode deaths (19.5%). This indicates a need for ongoing assessor training and support, and (inter) national comparisons of practice"
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Impey ORE, Baker JD, Smyth RS, Potts SG. Death after psychiatric contraindications to urgent liver transplant for paracetamol overdose. World J Transplant 2025; 15(3): 101865
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"Paediatric liver transplantation (PLT) is a life-saving procedure for children with advanced liver disease or hepatoblastoma. The ..."
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"Paediatric liver transplantation (PLT) is a life-saving procedure for children with advanced liver disease or hepatoblastoma. The number of available grafts is limited in relation to the number of children on PLT waiting list. One of the limitations is the donor obesity. Donors’ obesity is strongly associated with hepatic steatosis which can affect graft function by impairing microcirculation and maximizing the potential of ischemia-reperfusion injury. This important study faces this problem and offers a possible solution. New strategies to optimize the grafts before PLT such as normothermic regional perfusion and ex vivo liver perfusion can potentially mitigate the risk of using grafts from obese donors.The study in particular treats new strategies to optimize the grafts before PLT such as normothermic regional perfusion and ex vivo liver perfusion can potentially mitigate the risk of using grafts from obese donors.
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Alnagar A, Amgad A, Grammatikopoulos T, Kyrana E. Impact of donor obesity on paediatric liver transplantation; current evidence and potentials for graft pool expansion. World J Transplant 2025; 15(3): 103015
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"Very important study on the management of patients with doner-specific antibodies detected
by Luminex pre-transplantation. ..."
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"Very important study on the management of patients with doner-specific antibodies detected
by Luminex pre-transplantation. Pretransplant low-level donor-specific antibodies (DSAs) detected by the Luminex platform are associated with favorable graft outcomes after 1 year and 10 years in kidney transplant recipients. This study highlighted the appropriate immunosuppressive induction and maintenance protocols. These patients experienced low rates of acute rejection and sustained satisfactory long-term graft function and survival.
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Abbas K, Mubarak M, Musharraf W, Hafeez AR, Aziz T, Zafar MN. Impact of low-level pretransplant donor-specific antibodies detected by the Luminex platform on acute rejection and long-term graft survival. World J Transplant 2025; 15(3): 104308
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"Very interesting study on a critical point involving transplantatio. Indeed,Fertility preservation and pregnancymanagement are critical ..."
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"Very interesting study on a critical point involving transplantatio. Indeed,Fertility preservation and pregnancymanagement are critical considerations for patients undergoing organtransplantation.
This mini-review explores advancements in cryopreservationtechniques, pre-conception counseling, and multidisciplinary strategies forsafe pregnancies post-transplantation. Emphasis is placed on balancing maternalhealth, graft function, and fetal outcomes. Fertility preservation and pregnancymanagement are critical considerations for patients undergoing organtransplantation."
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Lazarov V, Naseva E, Miteva DG, Tomov LP, Shumnalieva R, Peruhova M, Velikova T. Advances in fertility preservation and pregnancy care for transplant patients. World J Transplant 2025; 15(3): 103958
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"Heart transplantation is a life-saving procedure for many people throughout the world. However, organ availability remains a major ..."
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"Heart transplantation is a life-saving procedure for many people throughout the world. However, organ availability remains a major limiting factor affecting transplant volume. This mandates that innovation must take place to increase the supply of donor organs. This study outline several of the proposed strategies, including splitting the donor heart to provide multiple partial heart transplants, domino partial heart transplantation, changes in legislation including opt-out legislation, and xenotransplantation.
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Alexander B, Javed H, Furrukh A, Joshi K, Steen L, Rajab TK. Innovative strategies to increase cardiac donor availability. World J Transplant 2025; 15(3): 102768
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"The impact of major cardiovascular events on the outcomes of kidney transplant patients is extremely important. In this original study, ..."
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"The impact of major cardiovascular events on the outcomes of kidney transplant patients is extremely important. In this original study, the authors report the role of the blood levels of uric acid on the frequency of MACEs. the statitstical analysi here reported i well done and relevant. MACEs occurred in 145 of 545 (26.6%) KT recipients. The most prevalent comorbidities were hypertension (87%), dyslipidemia (78%), secondary hyperparathyroidism (68%), HU (63%) and anemia (33%). In the multivariate logistic regression model, the most significant factors associated with MACEs were previous CV events [odds ratio (OR) = 70.6, 95%CI: 24.9–200.1], left ventricular hypertrophy (LVH) (OR = 12.6, 95%CI: 2.7– 58.3), HU treatment (OR = 4.3, 95%CI: 2.4–7.6), and anemia (OR = 5.3, 95%CI: 2.9–9.8). Effect modification by the presence of HU revealed that independent factors associated with MACEs were age (OR = 1.03, 95%CI: 1.0–1.1), previous CV events (OR = 41.7, 95%CI: 13.6–127.6), LVH (OR = 15.3, 95%CI: 2.0–116.6), HU treatment (OR = 2.5, 95%CI: 1.3–4.6) and anemia (OR = 5.4, 95%CI: 2.8–10.5). Effect modification by UA levels dichotomized at 475 μmol/L (very high level of UA) revealed that HU treatment was not associated with MACEs in groups with or without very high UA levels.
"
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Junk E, Tzivian L, Folkmane I, Folkmanis K, Jushinskis J, Strazda G, Folkmanis V, Kuzema V, Petersons A. Major adverse cardiovascular events and hyperuricemia as an effect-modifying factor in kidney transplant recipients. World J Transplant 2025; 15(3): 102287
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"Even this is a case report, its importance is due to the rarity of the problematis exposed and the treatment succesful. Despite ..."
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"Even this is a case report, its importance is due to the rarity of the problematis exposed and the treatment succesful. Despite numerous challenges, the patient achieved a successful recovery with satisfactory graft function and was free from lymphorrhea/lymphedema in her left lower limb 3 years post-transplantation. This case underscores the importance of robust infection control during both the pre- and post-transplantation phases and highlights the potential of LVA as a treatment option for managing lymphorrhea and infections in patients with liver cirrhosis.
"
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Wu TW, Hou TY, Yang JCS, Wang CC. First report of successful liver transplantation following supermicrosurgical lymphaticovenous anastomoses for lymphorrhea with intractable infection: A case report. World J Transplant 2025; 15(3): 101496
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" De novo malignancies (DNMs) are a major concern, accounting for 20%-25% of deaths in LT recipients surviving beyond the early ..."
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" De novo malignancies (DNMs) are a major concern, accounting for 20%-25% of deaths in LT recipients surviving beyond the early post-transplant period. Non-melanoma skin cancers, particularly squamous cell carcinoma are the most prevalent DNMs. Other significant malignancies include Kaposi's sarcoma, post-transplant lymphoproliferative disorders, and various solid organ cancers, including head and neck cancers.
This is a very interesting paper over the issue of cancers de novo in liver transplant patients
"
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Singh A, Singh C, Dhaliwal A, Singh N, Kumar V, Sohal A, Schneider J. Incidence, screening, and management of de novo malignancies in liver transplant patients: A review. World J Transplant 2025; 15(3): 101046
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"A rather good paoer as many others on the same issue. the paper stresses the impact of covid 19 on the transplanted patients or on ..."
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"A rather good paoer as many others on the same issue. the paper stresses the impact of covid 19 on the transplanted patients or on the patients waiting to be transplanted. important paper for the physicians dealing with transplantation. the recommendation offered by the authors should be carefully followed to reduce the impact of covid 19 over the transplant activity"
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Bozkurt HB, Özdemir Ö. Changes regarding solid organ transplantation during the COVID-19 pandemic. World J Transplant 2025; 15(3): 100591
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"The article adheres to the ethical standards of the institutional and national research committees, as well as with the 1964 Helsinki ..."
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"The article adheres to the ethical standards of the institutional and national research committees, as well as with the 1964 Helsinki Declaration and its later amendments or equivalent ethical guidelines. The study methods are robust, using a large national database based on retrospective data, and appropriate statistical analysis, allowing reproducibility. Results are authentic and statistically validated, offering meaningful insights into cardiovascular risks among metabolically healthy obese postmenopausal women. Tables and figures are clear, well-constructed, and support the data effectively. References are up-to-date and relevant to the field. The manuscript is written clearly and concisely. Language throughout the article is clear, academic, and concise. However, the study acknowledges limitations due to retrospective design and database reliance. Furthermore, the study lacks detailed BMI distribution data, and, as noted by the authors, it does not explore the potential impact of lifestyle factors on MACCE outcomes. No long-term follow-up data is recorded and the study population is exclusively composed of postmenopausal women who required hospitalization, which may limit the generalizability of the findings to the broader outpatient population."
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Pingili A, Desai R, Vempati R, Vemula M, Lakkimsetti M, Madhavaram H, Nanjundappa A, Singh S, Sunkara P, Gummadi J. Prevalence and impact of metabolically healthy obesity on cardiovascular outcomes in postmenopausal women and disparities: An age-matched study. World J Cardiol 2025; 17(4): 105842
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"1. Is the patient's age compatible with the diagnosis of congenital renal arteriovenous fistula? What is the common age group for ..."
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"1. Is the patient's age compatible with the diagnosis of congenital renal arteriovenous fistula? What is the common age group for a typical congenital RAVF?
2. Instead of summarising the details of the case under the conclusion, a 'take home' message including when to suspect, what to do can be helpful for the reader."
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Lv SP, Qin LL, Mou H, Huang T, Wang KQ. Multimodal imaging techniques for the diagnosis of congenital left renal arteriovenous fistula: A case report. World J Clin Cases 2025; 13(21): 104062
16
"1. The introduction section is lengthy and packed with information. The purpose of the introduction is to inform the reader about ..."
[Read more]
"1. The introduction section is lengthy and packed with information. The purpose of the introduction is to inform the reader about the background, which can be a brief overview rather than an exhaustive one.
2. The discussion can include the cost and other potential limitations of circulating tumor DNA.
3. The likely future prospects such as need for a multicentre / institutional prospective randomised trial can be included in the discussion. "
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Zhou XY, Jiang YJ, Guo XM, Han DH, Liu Y, Qiao Q. Application of circulating tumor DNA liquid biopsy in nasopharyngeal carcinoma: A case report and review of literature. World J Clin Cases 2025; 13(21): 105066
17
"1. The order of the case report can be changed to bring clarity and understanding in the following manner. Chief complaints to be ..."
[Read more]
"1. The order of the case report can be changed to bring clarity and understanding in the following manner. Chief complaints to be followed by other history (past, present, family), physical examination, laboratory findings, imaging in a sequence so that the reader can appreciate the methodical work up.
2. The conclusion can include the importance of imaging (MRI > US) in avoiding unnecessary surgery"
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Ali S, Anjum A, Nasir KM, Khalid AR, Shahzad F, Nashwan AJ. Ovarian vein thrombosis mimicking acute appendicitis: A case report. World J Clin Cases 2025; 13(21): 103525
18
"1. The title does not indicate the study type. To include the type of article (descriptive review)
2. General principles of Gastro ..."
[Read more]
"1. The title does not indicate the study type. To include the type of article (descriptive review)
2. General principles of Gastro Intestinal Stromal Tumor resection can be outlined (minimal handling, avoiding tumor rupture, maintaining surgical margins, etc)
3. The management can be summarised in a table/algorithm format
4. Inclusion of more figures can be helpful in better understanding"
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Chen LQ, Wu CY, Wu SJ, Ye K. Laparoscopic surgical approaches for various locations of gastrointestinal stromal tumours. World J Clin Cases 2025; 13(21): 105559
19
"In this editorial, the authors emphasize the importance of Creeping Fat (CF) as a predictor indicating poor prognosis in Crohn's ..."
[Read more]
"In this editorial, the authors emphasize the importance of Creeping Fat (CF) as a predictor indicating poor prognosis in Crohn's disease. The authors speculate that CF is associated with specific characteristics of small bowel Crohn's disease and present several reports to support this hypothesis. However, their description is more narrative than statistical. To strengthen their speculation, it would be better to include numerical data. Overall, while the editorial raises interesting points about CF, it would benefit from more quantitative evidence."
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Wei H, Mai ZL, Ma BT, Chang B. Creeping fat: A promising radiological predictor in small bowel Crohn’s disease. World J Gastroenterol 2025; 31(16): 105186
20
"In addition to the discussion focusing on the morphalogy and volume of the pituitary neuroendocrine tumor in the editorial, the ..."
[Read more]
"In addition to the discussion focusing on the morphalogy and volume of the pituitary neuroendocrine tumor in the editorial, the function status of a pituitary neuroendocrine tumor, target organs response, relevant homones, permissive action of hormone, and other factors should be addressed. Some tumors are large in size, but their functions are weak and secret less hormones, result in mild or moderate hazard; vice versa. "
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Yang JS. Prognosis value of pituitary neuroendocrine tumor volume. World J Radiol 2025; 17(4): 106186
15247 items Read more >>
Peer-Reviewers and Manuscript Statistics
- Editorial board members
- 2266
- Peer-reviewers
- 30843
- Manuscripts received today
- 2
- Manuscript reviews today
- 17
- Unhandled manuscripts today
- 165
- Active peer-reviewers today
- 1390
- Reviewer acceptance today
- 45
- Reviewer refusals today
- 34
- Total accepted manuscripts
- 35935
- Total rejected manuscripts
- 41581
- Total peer-reviewers
- 4214364
- Total submissions
- 34143
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68705 items Read more >>
1
"This review article presents a comprehensive synthesis of recent developments in conversion therapy for intrahepatic ..."
[Read more]
"This review article presents a comprehensive synthesis of recent developments in conversion therapy for intrahepatic cholangiocarcinoma (ICC), specifically focusing on strategies to render initially unresectable disease amenable to surgical resection. The authors have successfully compiled and analyzed a broad range of relevant studies, providing a balanced overview of multimodal treatment approaches, including systemic chemotherapy, targeted therapy, immunotherapy, and locoregional interventions such as TACE, TARE, and HAIC. The manuscript is commendable for its integration of recent clinical data and its emphasis on multidisciplinary management, which aligns with current oncologic practice. The inclusion of well-organized tables and illustrative figures contributes to the accessibility and clarity of the content. Furthermore, the discussion of strategies aimed at optimizing the future liver remnant—such as portal vein embolization (PVE) and ALPPS—offers valuable clinical insights for hepatobiliary surgeons and oncologists alike. To further strengthen the manuscript, the following suggestions are offered: 1. A more explicit and operational definition of “conversion therapy” would improve conceptual clarity, particularly if contrasted with related terms such as “bridging therapy” and “downstaging.” 2. While Figure 1 is informative, reformatting it into a structured algorithm or decision-making flowchart could enhance its clinical utility and instructional value. 3. The generalizability of findings from small-scale or non-standardized studies should be addressed, as this would add depth to the critical appraisal and enhance the scholarly rigor of the discussion. In conclusion, this review represents a timely and academically significant contribution to the evolving field of hepatobiliary oncology. With modest revisions, it has the potential to serve as both an educational reference and a practical guide for clinicians managing advanced ICC. "
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Liu JJ, Zhou M, Yuan T, Huang ZY, Zhang ZY. Conversion treatment for advanced intrahepatic cholangiocarcinoma: Opportunities and challenges. World J Gastroenterol 2025; 31(15): 104901
2
"The title of this paper should condense the main idea of the article and clearly indicate that it is a retrospective study. The ..."
[Read more]
"The title of this paper should condense the main idea of the article and clearly indicate that it is a retrospective study. The description of research methods is not specific and clear enough. The citation of literature should include more recent references, which will increase the novelty and scientific value of the paper. "
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Wu YP, Zhou JX, Wu HB, Wu DP, Qin LZ, Qin B, Xu XY, Yehya SAA, Cheng Y. Clinical characteristics and risk factors of esophageal reflux hypersensitivity: A multicenter study. World J Gastroenterol 2025; 31(17): 105281
3
"The retrospective study by Zhao et al. offers critical insights into sex-based differences in achalasia symptomatology and outcomes ..."
[Read more]
"The retrospective study by Zhao et al. offers critical insights into sex-based differences in achalasia symptomatology and outcomes following peroral endoscopic myotomy (POEM). By analyzing 526 cases over a decade, the authors address a significant gap in understanding how sex influences preoperative presentation, manometric parameters, and postoperative recovery. While the study reaffirms POEM’s efficacy and highlights sex-specific nuances, two methodological limitations warrant attention: the absence of normality testing for data distribution and incomplete reporting of statistical metrics in tables. These omissions slightly undermine the robustness of the statistical analysis but do not negate the study’s overall contributions. "
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Zhao CY, Xu N, Dong H, Chai NL, Linghu EQ. Effect of sex on the outcomes of peroral endoscopic myotomy for the treatment of achalasia. World J Gastroenterol 2025; 31(17): 104579
4
"This review by Liu and He provides a comprehensive exploration of intelligent hydrogel-based dressings for diabetic wound management. ..."
[Read more]
"This review by Liu and He provides a comprehensive exploration of intelligent hydrogel-based dressings for diabetic wound management. Chronic diabetic wounds, characterized by impaired or delayed healing due to multiple physiological disruptions, demand innovative solutions. The authors systematically categorize hydrogels into natural, synthetic, and composite types, dissecting their structural and functional mechanisms while highlighting their clinical potential. Below is a critical analysis of the article’s strengths, limitations, and future implications. The article is well-organized, progressing logically from the pathophysiology of diabetic wounds to hydrogel design, responsiveness mechanisms, applications, and future challenges. This structure helps readers understand the progression from fundamental biological science to clinical findings in translational studies. The integration of materials science, nanotechnology, and biotechnology is a highlight. For instance, the discussion on composite hydrogels incorporating silver nanoparticles or conductive polymers demonstrates how hybrid materials enhance antibacterial efficacy and mimic bioelectrical environments. The inclusion of emerging technologies like 3D printing and real-time monitoring systems reflects a forward-thinking approach. The authors bolster their claims with recent preclinical and clinical studies (e.g., phase 4 trials of Fitostimoline and SANTYL hydrogels). References to advanced functionalities, such as glucose-responsive insulin release or photothermal antibacterial activity, are supported by robust experimental data, lending credibility to the proposed applications. The emphasis on personalized precision medicine aligns with current trends in healthcare. The concept of hydrogels adapting to wound microenvironment changes (pH, temperature, biomarkers) for tailored drug delivery represents a paradigm shift from traditional "one-size-fits-all" therapies. The article does have some limitations. In terms of clinical translation challenges, while the article acknowledges barriers like high costs and biocompatibility concerns, it lacks actionable strategies for overcoming these hurdles. For example, cost reduction could be addressed through scalable manufacturing techniques or public-private partnerships, yet these solutions are only briefly mentioned. Certain sections, particularly those detailing chemical cross-linking mechanisms or nanomaterial interactions, may alienate non-specialist readers. Simplifying jargon or incorporating analogies (e.g., comparing hydrogel networks to "smart sponges") could improve accessibility. In addition, long-term biocompatibility and potential side effects of nanomaterials (e.g., silver nanoparticle toxicity) are underexplored. A discussion on regulatory pathways or post-market surveillance would strengthen the clinical relevance of the review. For future direction of dressings development, combining hydrogel dressings with wearable sensors or AI-driven diagnostics could enable closed-loop systems for real-time wound management. For instance, hydrogels equipped with IoT-enabled sensors might autonomously adjust drug release based on cloud-analyzed biomarker data. Exploring eco-friendly materials (e.g., biodegradable polymers) and energy-efficient production methods would address environmental concerns. Additionally, cost-benefit analyses comparing hydrogel dressings to standard care could incentivize healthcare adoption. Future studies should prioritize patient feedback to improve usability, such as optimizing hydrogel adhesion for mobility or reducing dressing change frequency. Ethnographic studies on patient adherence could inform design modifications. In conclusion, Liu and He’s review underscores the transformative potential of intelligent hydrogels in diabetic wound care, bridging scientific innovation with clinical needs. By addressing microenvironmental challenges through responsive drug delivery, antibacterial action, and tissue regeneration, these materials represent a leap toward personalized medicine. However, translating laboratory success to bedside application requires tackling economic, technical, and regulatory barriers. Future efforts must prioritize interdisciplinary collaboration, patient-centric design, and sustainable scaling to unlock the full promise of intelligent hydrogels. This article serves as both a foundational reference and a call to action for researchers, clinicians, and policymakers to reimagine diabetic wound management. "
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Liu H, He L. Intelligent hydrogel-based dressings for treatment of chronic diabetic wounds. World J Diabetes 2025; 16(5): 104937
5
"This article provides important data and insights for the study of reflux hypersensitivity (RH). The study is well-designed as a ..."
[Read more]
"This article provides important data and insights for the study of reflux hypersensitivity (RH). The study is well-designed as a multicenter, large-sample, retrospective investigation, comprehensively analyzing the clinical characteristics and risk factors of patients with reflux hypersensitivity (RH). The assessment is extensive, covering symptoms, esophageal motility, impedance-pH monitoring, and psychological factors, revealing the significance of weakly acidic reflux (WAR) and non-acid reflux (NAR) in RH. The use of multiple statistical methods ensures the scientific reliability of the results. However, there are some limitations. Despite involving three medical centers, the sample size is still relatively small, with only 109 cases. The follow-up period is short, from January 2022 to December 2023, which may limit the generalizability of the study results and the assessment of long-term effects. The study mainly focuses on the clinical characteristics and risk factors of RH, but there is relatively little analysis of treatment response and prognosis in patients. The article uses the Hamilton Anxiety Scale and the Hamilton Depression Scale to assess the psychological status of patients, but it does not evaluate the effectiveness of psychological interventions in RH patients. "
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Wu YP, Zhou JX, Wu HB, Wu DP, Qin LZ, Qin B, Xu XY, Yehya SAA, Cheng Y. Clinical characteristics and risk factors of esophageal reflux hypersensitivity: A multicenter study. World J Gastroenterol 2025; 31(17): 105281
6
"This article investigates the therapeutic potential of BIC in the context of MASLD, with a particular focus on its effects on lipid ..."
[Read more]
"This article investigates the therapeutic potential of BIC in the context of MASLD, with a particular focus on its effects on lipid metabolism and inflammation. BIC, an alkaloid traditionally recognized as a GABA receptor antagonist, is presented as a novel therapeutic candidate for MASLD. This exploration is particularly intriguing, as the GABAergic pathways are well-documented for their roles within the nervous system; however, the investigation into BIC’s impact on hepatic lipid metabolism and inflammatory processes remains relatively novel and promising. The utilization of zebrafish, HepG2, and AML12 cellular models, alongside mouse models induced by a MCD diet, significantly enhances the validity of the findings. By employing multiple experimental models, the researchers provide robust evidence supporting the efficacy of BIC in alleviating MASLD, which is essential for the translation of these findings into clinical practice. Furthermore, the absence of significant toxicity observed in zebrafish embryos and cellular models, even at relatively high concentrations of BIC, suggests a favorable safety profile for this compound. This aspect is critical, as it bolsters the notion that BIC could potentially be developed into a therapeutic agent devoid of the toxic effects commonly associated with alternative treatments. However, while the study offers compelling evidence from preclinical models, it is imperative to investigate the long-term effects of BIC. Given that MASLD can progress to more severe forms, such as steatohepatitis and fibrosis, long-term studies are necessary to ascertain whether BIC can effectively prevent such progression. Moreover, although the results of the study confirm the absence of significant toxicity associated with the drug, the relationship between its pharmacological mechanisms and GABA warrants further discussion, or at the very least, should be acknowledged in the limitations section. "
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Wang XM, Dai Z, Lu DJ, Bao CQ, Yang NB, Zhou YP. Bicuculline ameliorates metabolic dysfunction-associated steatotic liver disease by inhibiting the nuclear factor-kappa B pathway and reducing lipid accumulation. World J Gastroenterol 2025; 31(17): 105438
7
"Title: Interventional effect of hesperetin on N-methyl-N’-nitro-N-nitrosoguanidine-induced exosomal circ008274 in affecting normal ..."
[Read more]
"Title: Interventional effect of hesperetin on N-methyl-N’-nitro-N-nitrosoguanidine-induced exosomal circ008274 in affecting normal cells to promote gastric carcinogenesis. The study proved that hesperetin aleviated the gastric carcinogenesis by mediating exosome-derived circ0008274 targeting miR-526b-5p. The hesperidin-mediated exosomes circ0008274/miR-526b-5p axis and it can serve as a potential target for slowing the onset of gastric cancer. These findings play an important role in the management of gastric precancerous lesions. The overall study is good but this research used bioinformatics technique and future researches are need to used the integration of bioinformatics, genomics, and proteomics to give more explanation for the protective effect of hesperetin on the gastric cancer. "
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Liang ZF, Xu YM, Song JJ, Gao ZH, Qian H, Xu XZ. Interventional effect of hesperetin on N-methyl-N’-nitro-N-nitrosoguanidine-induced exosomal circ008274 in affecting normal cells to promote gastric carcinogenesis. World J Gastroenterol 2025; 31(16): 104920
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"The current study is very interesting as the authors addressed the role of gut micro biota in pathogenesis of chronic hepatitis B ..."
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"The current study is very interesting as the authors addressed the role of gut micro biota in pathogenesis of chronic hepatitis B infection. They reported that the abundance of Dorea varies significantly across various stages of liver fibrosis, making it a potential microbial marker for identifying the onset and progression of liver fibrosis. This useful conclusion will pave the way for modification of treatment strategy of chronic hepatitis B infection However, I have two comments: 1-The selection of patients with a wide range of age : 18-80 may have an impact on the results. Previous studies have sown as individuals age, the gut microbiota undergoes significant changes in composition, diversity, and functionality , which have been linked to various health conditions, including cognitive decline and inflammatory diseases. 2-It would have been better to select two equal groups of patients from the start: one group with hepatic fibrosis and the other without fibrosis .Having the equal or nearly equal groups would make statistical analysis more fair as the groups already studied had one with 35 patients and the other with 102 patients. "
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Zhu Y, Geng SY, Chen Y, Ru QJ, Zheng Y, Jiang N, Zhu FY, Zhang YS. Machine learning algorithms reveal gut microbiota signatures associated with chronic hepatitis B-related hepatic fibrosis. World J Gastroenterol 2025; 31(16): 105985
9
"The authors have made a significant contribution by uncovering the role of the Interleukin-36 (IL-36) subfamily in liver cirrhosis, ..."
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"The authors have made a significant contribution by uncovering the role of the Interleukin-36 (IL-36) subfamily in liver cirrhosis, particularly highlighting the relationship between these cytokines and gut microbiota. This work provides a fresh perspective on the gut-liver axis, demonstrating how an imbalance in the gut microbiome might contribute to liver disease progression through inflammatory cytokine signaling. The innovation of the study lies in its identification of IL-36 cytokines, such as IL-36α, IL-36γ, IL-36Ra, and IL-38, as crucial players in the inflammatory processes associated with liver cirrhosis. By correlating these cytokines with gut microbiota alterations, the authors open new avenues for potential biomarkers and therapeutic targets in liver disease management. Their findings suggest that the IL-36 subfamily could help us better understand the pathophysiological mechanisms underlying liver cirrhosis and its association with dysbiosis in the gut microbiome. However, a notable limitation of the study is the lack of mechanistic exploration of how IL-36 cytokines mediate these effects in the liver. While the paper discusses correlations between IL-36 subfamily levels and gut microbiota, the underlying mechanisms linking these factors to liver cirrhosis progression are not fully explored. Further research into how IL-36 cytokines influence microbiota composition and how they interact with liver disease would enhance the understanding of the gut-liver axis. "
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Pan YZ, Chen WT, Jin HR, Liu Z, Gu YY, Wang XR, Wang J, Lin JJ, Zhou Y, Xu LM. Correlation between the interleukin-36 subfamily and gut microbiota in patients with liver cirrhosis: Implications for gut-liver axis imbalance. World J Hepatol 2025; 17(4): 105660
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"This paper evaluates the impact of sex on the outcomes of peroral endoscopic myotomy (POEM) in the treatment of esophageal achalasia. ..."
[Read more]
"This paper evaluates the impact of sex on the outcomes of peroral endoscopic myotomy (POEM) in the treatment of esophageal achalasia. POEM is concluded to be a safe and effective treatment for both men and women, with women potentially deriving greater benefit than men. The study further suggests that sex may influence the therapeutic effect and symptom improvement after POEM, with hormonal factors being particularly important in women. The short-term success rate of POEM surgery is 96.52%. Success is improving the Eckardt score to 3 or less without additional treatment. These results indicate that POEM is a highly effective first-line option for achalasia treatment. However, the technical difficulty of POEM is high, and even in Japan, where endoscopic therapy is widespread, the procedure is limited to a small number of high-volume centers. Addressing expanding access to this effective technique is a significant future challenge. "
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Zhao CY, Xu N, Dong H, Chai NL, Linghu EQ. Effect of sex on the outcomes of peroral endoscopic myotomy for the treatment of achalasia. World J Gastroenterol 2025; 31(17): 104579
11
"The manuscript addresses the role of exosomal miR-137-3p derived from hypoxia-injured endometrial epithelial cells (EECDs) in ..."
[Read more]
"The manuscript addresses the role of exosomal miR-137-3p derived from hypoxia-injured endometrial epithelial cells (EECDs) in regulating hucMSC behavior, which is of potential interest in the context of endometrial regeneration. However, several critical issues limit the scientific clarity and integrity of the current work: In the first part of the results, the authors performed RNA sequencing to compare miRNA expression profiles in hucMSCs treated with EECD-ex versus EEC-ex. However, Figure 7 implies that the differential expression of miR-137-3p originates from differences in the exosomal content of EECD-ex versus EEC-ex. This is a fundamental inconsistency. Changes in miRNA expression within recipient hucMSCs do not directly reflect the cargo of the exosomes unless validated by exosome profiling. Such discrepancy may mislead the interpretation regarding the source and function of miR-137-3p. The manuscript does not provide essential data on the characterization of exosomes (e.g., TEM, NTA, exosomal markers such as CD63, CD81, or TSG101). Moreover, it is unclear whether there is a difference in exosome yield (i.e., production efficiency or protein content) between EEC-ex and EECD-ex. The manuscript lacks transparency on how miR-137-3p was selected from the pool of 53 differentially expressed miRNAs. While functional assays were performed on hucMSCs, the study does not include gain- or loss-of-function experiments at the exosomal level (e.g., using miR-137-3p inhibitors/mimics in donor EECs before exosome collection). Such experiments are critical to directly establish causality between EECD-exosomal miR-137-3p and the observed hucMSC behavior. "
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Zhang WY, Liu SM, Wang HB, Deng CY. Exosomal miR-137-3p targets UBE3C to activate STAT3, promoting migration and differentiation into endometrial epithelial cell of human umbilical cord mesenchymal stem cells under hypoxia. World J Stem Cells 2025; 17(4): 100359
12
"A letter to the Editor entitled Hypoxic endometrial epithelial cell-derived microRNAs effectively regulate the regenerative properties ..."
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"A letter to the Editor entitled Hypoxic endometrial epithelial cell-derived microRNAs effectively regulate the regenerative properties of mesenchymal stromal cells by Dr Mallis elegantly comments on the significance of the study published by Dr Zhang. The author highlights the clinical significance of the data obtained from in vitro experiments and, at the same time, provides mechanistic insight into the role of mir-214-5p and 21-5p in mesenchymal stem cells’ functionality and reparability of endometrial endothelial cells. The author has rightfully suggested that the published data by Zhang et al. has been derived from in vitro experimentation and there is a need for supporting this data by in vivo experiments. The letter is fluently written and supplements the findings of Zhang et al. "
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Mallis P. Hypoxic endometrial epithelial cell-derived microRNAs effectively regulate the regenerative properties of mesenchymal stromal cells. World J Stem Cells 2025; 17(4): 102482
13
"Mubin Ozercan et al. presented an interesting article "Vonoprazan and proton pump inhibitors: Which is superior for Helicobacter ..."
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"Mubin Ozercan et al. presented an interesting article "Vonoprazan and proton pump inhibitors: Which is superior for Helicobacter pylori eradication?" The authors' decision to summarize current information on the effectiveness of anti-Helicobacter therapy based on the use of proton pump inhibitors and based on the use of potassium-competing acid blockers(P-CAB) was absolutely correct and timely. A large number of comparative studies are available in scientific medical databases. Confirmation of the high level of effectiveness of potassium-competing acid blockers has practical significance for use in various eradication treatment regimens. "
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Ozercan M, Tawheed A, Ismail A, Amer MS, El-Kassas M. Vonoprazan and proton pump inhibitors: Which is superior for Helicobacter pylori eradication? World J Gastroenterol 2025; 31(17): 103156
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"Title: Cardiac Metastatic Tumors: Revisiting Mechanisms and Future Perspectives To the Editor We read with great interest the article ..."
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"Title: Cardiac Metastatic Tumors: Revisiting Mechanisms and Future Perspectives To the Editor We read with great interest the article by Luo et al.[1] titled "Comprehensive understanding of a rare disease: Cardiac metastatic tumor, a double-center 10-year case review," recently published in World Journal of Cardiology. We congratulate the authors for providing valuable clinical insights into the rare and underrecognized entity of cardiac metastatic tumors (CMTs). The study's finding that intracardiac metastases are associated with a poorer prognosis compared to pericardial involvement aligns with prior autopsy-based observations[2,3], emphasizing the prognostic importance of metastatic localization within the cardiac structure. The authors' inclusion of cardiac biomarkers, such as BNP and troponin, as predictors of adverse outcomes is particularly commendable and may represent a step toward more precise risk stratification. Building upon these important findings, we wish to highlight several emerging directions that could deepen our understanding of CMTs: First, organotropism and pre-metastatic niche formation are increasingly recognized as critical determinants of metastatic dissemination[4,5]. Experimental studies have demonstrated that cardiac tissue exhibits a unique extracellular matrix composition and a dynamic immunological environment, which may preferentially attract circulating tumor cells[6]. Investigating the role of cardiac-specific chemokine axes, such as CXCL12-CXCR4 signaling, may provide new insights into the molecular determinants of cardiac colonization. Second, advanced imaging modalities warrant greater emphasis in the diagnostic pathway. While echocardiography remains the first-line modality, cardiac magnetic resonance (CMR) imaging and ^18F-FDG PET-CT possess superior tissue characterization capabilities, enabling differentiation between malignant and benign cardiac masses with higher sensitivity and specificity[7,8]. Early integration of these modalities could significantly alter the therapeutic trajectory for patients with occult cardiac involvement. Third, therapeutic approaches for CMTs remain largely individualized and empirical. Although palliative strategies predominate, isolated reports suggest that surgical resection or stereotactic radiotherapy may improve quality of life and survival in carefully selected patients[9]. Prospective studies incorporating molecular tumor profiling—such as HER2, EGFR, or ALK status—may refine patient selection and therapeutic planning[10]. Moreover, given the rising incidence of CMTs in the era of improved oncological survival, it is imperative to establish multicenter registries and collaborative research networks focusing specifically on cardiac oncology. Standardizing diagnostic criteria, staging systems, and treatment algorithms would provide an urgently needed framework for evidence-based clinical decision-making. In conclusion, Luo et al. have made a valuable contribution by elucidating the clinical and prognostic characteristics of CMTs. Future investigations integrating molecular oncology, advanced imaging, and standardized therapeutic strategies will be pivotal to improving the outcomes of patients with this rare but increasingly encountered condition. References 1.Luo LY, Yang TS, He Z, Lin L, Luo XL. Comprehensive understanding of a rare disease: Cardiac metastatic tumor, a double-center 10-year case review. World J Cardiol. 2025;17(2):101851. doi:10.4330/wjc.v17.i2.101851 2.Bussani R, De-Giorgio F, Abbate A, Silvestri F. Cardiac metastases. J Clin Pathol. 2007;60(1):27-34. doi:10.1136/jcp.2005.035105 3.Lam KY, Dickens P, Chan AC. Tumors of the heart: a 20-year experience with a review of 12,485 consecutive autopsies. Arch Pathol Lab Med. 1993;117(10):1027-1031. 4.Peinado H, Zhang H, Matei IR, et al. Pre-metastatic niches: organ-specific homes for metastases. Nat Rev Cancer. 2017;17(5):302-317. doi:10.1038/nrc.2017.6 5.Labelle M, Hynes RO. The initial hours of metastasis: the importance of cooperative host-tumor cell interactions during hematogenous dissemination. Cancer Discov. 2012;2(12):1091-1099. doi:10.1158/2159-8290.CD-12-0329 6.Shinde AV, Frangogiannis NG. Fibroblasts in myocardial infarction: a role in inflammation and repair. J Mol Cell Cardiol. 2014;70:74-82. doi:10.1016/j.yjmcc.2013.12.011 7.Bogaert J, Francone M. Cardiac tumors and masses: the role of cardiovascular magnetic resonance imaging. Eur Radiol. 2009;19(1):14-27. doi:10.1007/s00330-008-1161-0 8.Rahbar K, Seifarth H, Schäfers M, et al. Differentiation of malignant and benign cardiac tumors using 18F-FDG PET/CT. J Nucl Med. 2012;53(6):856-863. doi:10.2967/jnumed.111.099028 9.Yusuf SW, Bathina JD, Qureshi S, et al. Cardiac tumors in cancer patients: diagnosis, management, and prognosis. Oncologist. 2007;12(4):443-450. doi:10.1634/theoncologist.12-4-443 10.Nguyen DX, Bos PD, Massagué J. Metastasis: from dissemination to organ-specific colonization. Nat Rev Cancer. 2009;9(4):274-284. doi:10.1038/nrc2622 "
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Luo LY, Yang TS, He Z, Lin L, Luo XL. Comprehensive understanding of a rare disease: Cardiac metastatic tumor, a double-center 10-year case review. World J Cardiol 2025; 17(2): 101851
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"The low-cost and easy-to-obtain characteristics of the TyG index introduced in this article make it feasible for clinical translation, ..."
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"The low-cost and easy-to-obtain characteristics of the TyG index introduced in this article make it feasible for clinical translation, especially in resource-limited settings. However, the universality of the TyG index threshold is questionable, and the influence of metabolic characteristics (e.g., diet and genetics) in different populations needs to be considered. In addition, the role of TyG index in early gastric cancer and its relationship with the dynamic changes of tumor microenvironment have not been elucidated. It is worth noting that high TyG index may reflect enhanced metabolic reserve in advanced patients, while may promote malignant transformation in precancerous lesions, and this "double-edged sword" effect needs to be further explored. "
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Zhao CF, Liu XL, Wu NB, Xu ZF. Triglyceride-glucose index as a prognostic indicator in advanced gastric cancer: Insights and future research. World J Gastroenterol 2025; 31(17): 104794
16
"1、The study would be further strengthened if the authors could elaborate in greater detail on how STAT3 was identified and the ..."
[Read more]
"1、The study would be further strengthened if the authors could elaborate in greater detail on how STAT3 was identified and the specific mechanisms by which miR-137-3p regulates STAT3. 2、Frankly, the impact of miR-137-3p on p-STAT3 appears minimal, as shown in Figure 3B. 3、A more in-depth exploration of UBE3C’s role in modulating the STAT3 signaling pathway and its mechanistic underpinnings would enhance the study. For instance, investigating whether miR-137-3p influences STAT3 signaling following UBE3C knockdown could yield valuable insights. "
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Zhang WY, Liu SM, Wang HB, Deng CY. Exosomal miR-137-3p targets UBE3C to activate STAT3, promoting migration and differentiation into endometrial epithelial cell of human umbilical cord mesenchymal stem cells under hypoxia. World J Stem Cells 2025; 17(4): 100359
17
"comment to Rhapontin activates nuclear factor erythroid 2-related factor 2 to ameliorate ..."
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"comment to Rhapontin activates nuclear factor erythroid 2-related factor 2 to ameliorate 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced gastrointestinal dysfunction in Parkinson's disease mice We are delighted to have read the article titled "Rhapontin activates nuclear factor erythroid 2-related factor 2 to ameliorate 1-methyl-4-phenyl-1,2,3,6-tetrahydr- opyridine-induced gastrointestinal dysfunction in Parkinson's disease mice" authored by Xin-Yu Wang’s team in the World Journal of Gastroenterology. Parkinson’s disease (PD) is a multicentric neurodegenerative disorder characterized by the accumulation and aggregation of alfa-synuclein (α-syn) in the substantia nigra in the central nervous system (CNS) and in other neural structures(1). It is the second most common and the most rapidly rising neurodegenerative disease in the world(2). While the exact causes behind the increasing incidence and prevalence of PD remain unclear, contributing factors may include longer life expectancy, declining smoking rates, and exposure to environmental pollutants and toxins(3). Among the earliest manifestations of PD are gastrointestinal (GI) symptoms, which often precede the onset of motor impairments. GI dysfunction in PD is closely linked to the gut-brain axis, reflecting the bidirectional communication between the CNS and the GI tract in both health and disease (4). However, there are still limitations in the research on the relationship between PD and GI dysfunction, and the specific molecular mechanism has not been fully elucidated. In this study, the findings of Xin-Yu Wang’s team provide valuable insights and innovative approaches for PD treatment. This paper represents the first systematic demonstration that rhapontin alleviates gut-brain axis dysfunction in PD by activating colonic NRF2, thereby offering a novel therapeutic target for the disease. By integrating network pharmacology predictions with experimental validation, this study enhances its scientific robustness and credibility. Furthermore, a key discovery of this study is that the anti-inflammatory effects of rhapontin are predominantly localized to the intestinal tract rather than being mediated through the brain-derived NRF2 pathway. This provides experimental evidence supporting the "enteric pathology hypothesis" of PD (5). Overall, these findings present critical theoretical support for rhapontin as a promising therapeutic agent for GI dysfunction in PD. However, we have several exploratory comments regarding certain aspects of the study. First, extensive research has established the critical role of the gut-brain axis in mediating GI dysfunction associated with PD through interconnected pathophysiological mechanisms. For example, gut microbiota dysbiosis can compromise intestinal barrier integrity, leading to a "leaky gut" phenomenon. This allows lipopolysaccharides (LPS) to trigger immune cell activation and the release of pro-inflammatory cytokines, which contribute to systemic inflammation and increased blood-brain barrier (BBB) permeability. Consequently, peripheral inflammatory signals can spread to the CNS, and after that, pathological α-syn will aggregate in the dorsal motor nucleus of the vagus nerve (DMV) and the substantia nigra. The levels of pathological α-syn also increase mitochondrial fragmentation in the DMV, ultimately leading to PD pathophysiology (6). Pathogenic α-syn may spread from the gut to the brain, leading to the degeneration of the nigrostriatal dopaminergic system, thus increasing the risk of developing PD (7, 8). Supporting this, animal studies have shown that fecal microbiota transplantation from PD patients induces α-syn aggregation and dopaminergic neuron loss (9). Additionally, gut microbiota also can regulate neurotransmitter homeostasis by modulating dopamine (DA) and serotonin production, while short-chain fatty acids (SCFAs) help mitigate intestinal inflammation, reduce oxidative stress, and enhance BBB integrity to protect DA neurons(6, 10-12). One of the characteristics of PD is the progressive loss of DA neurons in the substantia nigra pars compacta (13). Lastly, dysbiotic gut microbiome (dysbiome) can impair mitochondrial energy metabolism, trigger the TLR4/NF-κB pathway, and exacerbate oxidative stress, ultimately leading to the degeneration of nigral dopaminergic neurons (6). Collectively, these mechanisms form a core network through which the gut-brain axis contributes to PD pathogenesis. In this study, only studied the effect between rhapontin and the gastrointestinal dysfunction caused by PD, without systematically combining the gut-brain axis with PD for research. Additionally, although gut microbiota play a pivotal role in the gut-brain axis of PD, the study does not evaluate the influence of rhapontin on microbiota composition or function (14-16). It remains unclear whether rhapontin indirectly activates NRF2 or reduces inflammation by modulating specific microbial populations. Future studies could explore this by employing approaches such as 16S rRNA sequencing or metagenomics to assess changes in fecal microbiota composition, alongside quantifying microbiota-derived metabolites. Such investigations would provide deeper insights into the gut-brain axis dynamics and further elucidate rhapontin’s mechanisms of action. Secondly, rhapontin is a stilbenoid glucoside compound, found in medicinal plant of rhubarb rhizomes. Research into the anti-inflammatory mechanisms of rhapontin has revealed its multi-pathway synergistic effects. For example, in LPS-induced endothelial cell inflammation models, rhapontin effectively suppresses nitric oxide (NO) and TNF-α production while downregulating the expression of Inducible Nitric Oxide Synthase (iNOS), Cyclooxygenase-2 (COX-2), and NADPH Oxidase - related genes (NOX-related genes). These effects are primarily achieved by inhibiting the activation of key proteins in the Nuclear Factor-kappa B (NF-κB) and Mitogen - Activated Protein Kinase (MAPK) signaling pathways(17). In terms of antioxidant regulation, rhapontin activates the NRF2 signaling pathway, which reduces Tumor Necrosis Factor-alpha (TNF-α) and Matrix Metalloproteinase-2 (MMP-2) levels in diabetic retinopathy models, while enhancing the expression of Interleukin – 10 (IL-10) and Tissue Inhibitor of Metalloproteinase-1 (TIMP-1) and inhibiting NF-κB nuclear translocation(18). Its anti-fibrotic properties are mediated through dual mechanisms: activating Adenosine Monophosphate - Activated Protein Kinase (AMPK) and inhibiting the Transforming Growth Factor – beta (TGF-β)/Smad pathway, which helps reverse abnormal extracellular matrix deposition and prevents the progression of pulmonary fibrosis(19). Additionally, rhapontin has been shown to improve colonic epithelial barrier function via Sirtuin 1 (SIRT1) signaling activation(20). Together, these findings systematically highlight rhapontin's integrative therapeutic effects through coordinated modulation of NF-κB/MAPK, AMPK/TGF-β/Smad, and SIRT1 signaling networks, addressing inflammation, oxidative stress, and fibrosis. The current study demonstrated that rhapontin effectively reduces inflammation by decreasing the levels of pro-inflammatory cytokines, including IL-6, TNF-α, and IL-1β, while also activating the NRF2 signaling pathway to improve gastrointestinal function. However, the study did not explore rhapontin's potential role in preventing the progression of pulmonary fibrosis through AMPK activation and inhibition of the TGF-β/Smad pathway, nor did it investigate its effects on improving colonic epithelial barrier function via activation of the SIRT1 signaling pathway. Additionally, while network pharmacology was used to predict shared targets between PD and rhapontin, and the top 10 key targets were identified using a protein-protein interaction (PPI) network, the relationship between these targets and NRF2 remains poorly defined. Moreover, the study lacks detailed mechanistic insights into the specific signaling pathways associated with NRF2, including its upstream and downstream regulatory mechanisms—an area that requires further investigation. The article also does not clearly explain how NRF2 was identified as a key target. o address these research gaps, future studies could employ techniques such as Western blotting (WB) and co-immunoprecipitation (Co-IP) to validate the protein-protein interactions between rhapontin's potential targets and NRF2. Additionally, methods such as quantitative real-time polymerase chain reaction (qPCR) or RNA sequencing could be used to analyze downstream gene expression regulated by NRF2. These approaches would provide a more comprehensive understanding of the molecular mechanisms underlying rhapontin's anti-inflammatory effects, offering deeper insights into its therapeutic potential for PD. In evaluating the experimental section of this study, some points warrant further discussion. First, regarding the presentation of the results: Figure 2A does not clearly label which specific experimental group each result corresponds to, making interpretation challenging. Additionally, the WB image in Figure 5A lacks clarity and does not exhibit an obvious trend in the results, which may hinder the ability to draw definitive conclusions. Second, concerning the experimental methods: the study utilized only two approaches—the open field test and the pole-climbing test—to assess the motor abilities of mice. While these methods provide useful insight, they may be insufficient for a comprehensive evaluation of motor behavior in PD. Incorporating additional behavioral experiments, such as the Morris water maze, eight-arm radial maze, and elevated plus maze, could allow for a more thorough assessment of motor and cognitive functions in the mouse model (21). In summary, Wang XY’s team has conducted pioneering research, offering significant insights into the therapeutic potential of rhapontin for GI dysfunction in PD. This work is highly commendable, and we look forward to the authors addressing the aforementioned concerns in future studies through more detailed experimental design and exploration. Such efforts would further enhance the robustness and comprehensiveness of their findings. 1. Koga S, Sekiya H, Kondru N, Ross OA, Dickson DW Neuropathology and molecular diagnosis of Synucleinopathies. Mol Neurodegener. 2021;16(1):83. 2. delete Global, regional, and national burden of Parkinson's disease, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol. 2018;17(11):939-53. 3. Bloem BR, Okun MS, Klein C Parkinson's disease. Lancet. 2021;397(10291):2284-303. 4. Gao V, Crawford CV, Burré J The Gut-Brain Axis in Parkinson's Disease. Cold Spring Harb Perspect Med. 2025;15(1). 5. Safarpour D, Sharzehi K, Pfeiffer RF Gastrointestinal Dysfunction in Parkinson's Disease. Drugs. 2022;82(2):169-97. 6. Munoz-Pinto MF, Candeias E, Melo-Marques I, Esteves AR, Maranha A, Magalhães JD, Carneiro DR, Sant'Anna M, Pereira-Santos AR, Abreu AE, Nunes-Costa D, Alarico S, Tiago I, Morgadinho A, Lemos J, Figueiredo PN, Januário C, Empadinhas N, Cardoso SM Gut-first Parkinson's disease is encoded by gut dysbiome. Mol Neurodegener. 2024;19(1):78. 7. Kim S, Kwon SH, Kam TI, Panicker N, Karuppagounder SS, Lee S, Lee JH, Kim WR, Kook M, Foss CA, Shen C, Lee H, Kulkarni S, Pasricha PJ, Lee G, Pomper MG, Dawson VL, Dawson TM, Ko HS Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson's Disease. Neuron. 2019;103(4):627-41.e7. 8. Van Den Berge N, Ferreira N, Gram H, Mikkelsen TW, Alstrup AKO, Casadei N, Tsung-Pin P, Riess O, Nyengaard JR, Tamgüney G, Jensen PH, Borghammer P Evidence for bidirectional and trans-synaptic parasympathetic and sympathetic propagation of alpha-synuclein in rats. Acta Neuropathol. 2019;138(4):535-50. 9. Tan AH, Lim SY, Lang AE The microbiome-gut-brain axis in Parkinson disease - from basic research to the clinic. Nat Rev Neurol. 2022;18(8):476-95. 10. Du J, Zhang P, Tan Y, Gao C, Liu J, Huang M, Li H, Shen X, Huang P, Chen S Idiopathic Rapid Eye Movement Sleep Behavior Disorder (iRBD) Shares Similar Fecal Short-Chain Fatty Acid Alterations with Multiple System Atrophy (MSA) and Parkinson's Disease (PD). Mov Disord. 2024;39(8):1397-402. 11. Nishiwaki H, Hamaguchi T, Ito M, Ishida T, Maeda T, Kashihara K, Tsuboi Y, Ueyama J, Shimamura T, Mori H, Kurokawa K, Katsuno M, Hirayama M, Ohno K Short-Chain Fatty Acid-Producing Gut Microbiota Is Decreased in Parkinson's Disease but Not in Rapid-Eye-Movement Sleep Behavior Disorder. mSystems. 2020;5(6). 12. Wang Q, Luo Y, Ray Chaudhuri K, Reynolds R, Tan EK, Pettersson S The role of gut dysbiosis in Parkinson's disease: mechanistic insights and therapeutic options. Brain. 2021;144(9):2571-93. 13. Tolosa E, Garrido A, Scholz SW, Poewe W Challenges in the diagnosis of Parkinson's disease. Lancet Neurol. 2021;20(5):385-97. 14. Sampson TR, Debelius JW, Thron T, Janssen S, Shastri GG, Ilhan ZE, Challis C, Schretter CE, Rocha S, Gradinaru V, Chesselet MF, Keshavarzian A, Shannon KM, Krajmalnik-Brown R, Wittung-Stafshede P, Knight R, Mazmanian SK Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson's Disease. Cell. 2016;167(6):1469-80.e12. 15. Zhao Z, Ning J, Bao XQ, Shang M, Ma J, Li G, Zhang D Fecal microbiota transplantation protects rotenone-induced Parkinson's disease mice via suppressing inflammation mediated by the lipopolysaccharide-TLR4 signaling pathway through the microbiota-gut-brain axis. Microbiome. 2021;9(1):226. 16. Metta V, Leta V, Mrudula KR, Prashanth LK, Goyal V, Borgohain R, Chung-Faye G, Chaudhuri KR Gastrointestinal dysfunction in Parkinson's disease: molecular pathology and implications of gut microbiome, probiotics, and fecal microbiota transplantation. J Neurol. 2022;269(3):1154-63. 17. Li R, Chinnathambi A, Alharbi SA, Shair OHM, Veeraraghavan VP, Surapaneni KM, Rengarajan T Anti-inflammatory effects of rhaponticin on LPS-induced human endothelial cells through inhibition of MAPK/NF-κβ signaling pathways. J Biochem Mol Toxicol. 2021;35(5):e22733. 18. Shi Q, Cheng Y, Dong X, Zhang M, Pei C, Zhang M Effects of rhaponticin on retinal oxidative stress and inflammation in diabetes through NRF2/HO-1/NF-κB signalling. J Biochem Mol Toxicol. 2020;34(11):e22568. 19. Tao L, Cao J, Wei W, Xie H, Zhang M, Zhang C Protective role of rhapontin in experimental pulmonary fibrosis in vitro and in vivo. Int Immunopharmacol. 2017;47:38-46. 20. Wei W, Wang L, Zhou K, Xie H, Zhang M, Zhang C Rhapontin ameliorates colonic epithelial dysfunction in experimental colitis through SIRT1 signaling. Int Immunopharmacol. 2017;42:185-94. 21. Tuersong T, Wu QF, Chen Y, Shan Li P, Yong YX, Shataer M, Shataer S, Ma LY, Yang XL Integrated network pharmacology, metabolomics, and microbiome studies to reveal the therapeutic effects of Anacyclus pyrethrum in PD-MCI mice. Phytomedicine. 2025;142:156729. "
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Wang XY, Liu F, Wang QT, Li SZ, Ye YZ, Chen T, Cai BC. Rhapontin activates nuclear factor erythroid 2-related factor 2 to ameliorate 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced gastrointestinal dysfunction in Parkinson's disease mice. World J Gastroenterol 2025; 31(15): 104875
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"Name of Journal:World Journal of Hepatology Manuscript NO: Manuscript Type: LETTER TO THE EDITOR Commentary: Multi-omics reveals the ..."
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"Name of Journal:World Journal of Hepatology Manuscript NO: Manuscript Type: LETTER TO THE EDITOR Commentary: Multi-omics reveals the associations among the fecal metabolome,intestinal bacteria, and serum indicators in patients with hepatocellular carcinoma Biao Wen,Yin-Ping Wang Biao Wen,Yin-Ping Wang,Department of Gastroenterology, The First Affiliated Hospital of Chengdu Medical College, Chengdu 610000, Sichuan Province, China Author contributions:Yin-Ping Wang wrote the original draft; Biao Wen contributed to conceptualization, writing, reviewing and editing; Yin-Ping Wang and Biao Wen participated in drafting the manuscript; and all authors have read and approved the final version of the manuscript. Supported by ORCID number：0000-0001-5226-5981 Corresponding author:Biao Wen,MD, PhD,Assistant Professor,Department of Gastroenterology, The First Affiliated Hospital of Chengdu Medical College,No. 312, Middle Section of Baoguang Avenue, Xindu District, Chengdu 610000, Sichuan Province, China. 820695761@qq.com Received: Revised: Accepted: Published online: Abstract: Recently, Feng J et al. published an important study. The research team revealed the associations of fecal metabolomics, intestinal bacteria and serum indicators in patients with hepatocellular carcinoma (HCC) through multi-omics analysis. The research results indicate that the composition of the metabolome and intestinal bacteria in fecal samples is expected to become a potential biomarker for the diagnosis of HCC. After a thorough review of their work, we put forward two insights regarding the impact of hepatitis B virus and antiviral drugs on the intestinal flora of HCC, the changes in intestinal microbiota in HCC and healthy control groups. Key Words: Liver neoplasms; Gastrointestinal microbiome; Antiviral drug; Comment; Core Tip: We conducted a rigorous assessment of the research by Feng et al., and put forward expert suggestions regarding the changes of HCC in the gut microbiota and the impact of hepatitis B virus and related antiviral drugs on the microbiota, in order to advance this scientific field. TO THE EDITOR After reading the study titled "Multi-omics reveals the associations among the fecal metabolome, intestinal bacteria, and serum indicators in patients with hepatocellular carcinoma" by Feng et al. published in the World Journal of Gastroenterology, we found it highly insightful. The authors employed integrated metabolomic and microbiomic approaches to elucidate the linkages between fecal metabolites, gut microbiota, and serum biomarkers in hepatocellular carcinoma (HCC) patients, providing new perspectives for the early diagnosis of HCC. Here, we would like to share our perspectives on the following aspects: The impact of hepatitis B virus (HBV) and antiviral therapies on gut microbiota alterations in HCC; Gut microbial differences between HCC patients and healthy controls. The first point: The changes in the gut microbiota of HCC and healthy control groups vary in different studies and may be influenced by multiple factors More and more studies have shown that the intestinal microbiota is related to the occurrence of HCC and is expected to become a biomarker for the diagnosis of HCC. In the study by Feng et al., it was concluded that Lachnospira, Streptococcus and Veillonella are representative differential bacterial genera in the feces of HCC patients. These three bacterial genera and their related metabolites may serve as unique biomarkers [1]. Most studies have shown that there are differences in theα-diversity orβ-diversity of the intestinal microbiota between HCC patients and healthy control groups. However, these differences may vary when further studying the intestinal microbiota of HCC patients, such as at the genus level or species level. Zhang et al. found that Enterococcaceae, Lactobacillus, Bacillus and Gammaproteobacteria can be used as diagnostic markers for primary liver cancer (PLC). In addition, a correlation analysis was conducted, and the results showed that Veillonella was significantly positively correlated with alpha-fetoprotein (AFP) in PLC patients[2]. In 2023, Zhang et al. demonstrated that at the family level, the abundance of Lachnospiraceae, Coriobacteriaceae, Eggerthellaceae and Synergistaceae in the liver cancer group was significantly reduced compared with the normal group. The abundances of Enterobacteriaceae, Fusobacteriaceae, Lactobacillus and Erysierysiaceae increased significantly. At the horizontal level, compared with the normal group, The liver cancer groups included Blautia, Fusicatenibacter, Anaerostipes, Lachnospiraceae_ND3007_group, GG-56, Eggerthella, Lachnospiraceae_FCS020_group and The abundance of Olsenella was significantly reduced. The abundance of Escherichia coli - Shigella, Prevotella_2 Tyzzerella_4, Clostridium erysipelum and Prevotella_2 Tyzzerella ₄ increased significantly. Meanwhile, alpha-fetoprotein (AFP) is positively correlated with the abundance of Streptococcus[3];Yang et al. confirmed through a prospective study that in terms of intestinal samples, the average relative abundance of Proteobacteria in the HCC group was significantly higher than that in the control group. The abundance of Streptococcus in oral and fecal samples of HCC patients was higher than that in the control group. Meanwhile, during the transition from a healthy state to liver cirrhosis and HCC, the content of streptococcus in the hepatocellular carcinoma and liver cirrhosis groups was much higher than that in the control group, and showed an upward trend during the disease progression. From the analysis of microbial correlations and clinical characteristics and functions among each group, both Streptococcus and Virongella were identified in the microbial communities of oral and intestinal samples, and both were in key positions in the microbial correlation network of fecal samples. Streptococcus and Virongella showed a consistent trend. Among them, the microbiome distribution was positively correlated with MELD, Child-Pugh, age, CCI, AFP, AST, ALT, GGT, Cre, LDL, Tchol, PT and INR, and negatively correlated with ALB, BMI, HDL, TG and PLT in HCC patients. This study has similarities with that of Feng J et al[4];In 2024, the research results of Jinato et al. indicated that HCC was enriched with five genera, including Bacteroides, Streptococcus, Ruminococcus, Veronistella and Clostridium erysibiricum. And Romboutsia, UCG-002, Lachnospiraceae NK4A-136, Eubacterium hallii group, Lachnospiraceae ND-3007 group, Erysipelotrichaceae Seven genera such as UCG-003 and Bilophila have low abundance in HCC patients[5]. From the above, it can be known that some studies have mentioned the three bacterial genera, Streptococcus, Veronella, and Lachnospira, in the HCC and healthy groups, showing an increase in the abundance of Streptococcus and Veronella, while the relative abundance of Lachnospira has decreased. However, in different studies, The reasons for the incomplete similarity in the abundance and structure of the intestinal microbiota between HCC and the healthy control group may be related to the drug use, alcohol consumption, diet, racial and regional differences of HCC patients[6];A Western diet high in fat, cholesterol or sugar can induce dysbiosis of the gut microbiome, a reduction in symbiotic probiotics and an increase in opportunistic pathogens[7];For example, the formation of NAFLD-HCC induced by dietary cholesterol is related to intestinal flora imbalance, and the composition of the microbiota changes with the formation stage of NAFLD-HCC: Mucispirillum, Desulfovibrio, Anaerotruncus and Desulfovibrionaceae increased successively; Bifidobacterium and Bacteroides were depleted in mice fed with HFHC, which was also confirmed in patients with human hypercholesterolemia[8].Therefore, it is still necessary to further verify the unique biomarkers of HCC. The second point: Distinguish the independent effects of HBV infection and HCC and include data on the use of antiviral drugs Hepatitis B virus infection can directly disrupt the intestinal flora balance through systemic inflammatory responses and disorders of the hepatoenteric axis. The study by Shen et al. indicated that the flora composition of patients with HBV-CLD (such as enrichment of Streptococcus and reduction of Bifidobacterium) was significantly different from that of the healthy control group. It is suggested that HBV infection itself has unique microbiota characteristics; Meanwhile, antiviral drug treatment can partially reverse the dysbiosis caused by HBV[9-10]; Jinato et al. studied the changes in the gut microbiota between Viral (virus-HCC) and non-viral (NNC-HCC) -related hepatocellular carcinomas and found that compared with virus-HCC, the NNC-HCC subgroup significantly reduced various bacteria that produce short-chain fatty acids and the reduction of fecal butyrate[5];Liu et al. also analyzed the intestinal microbiota changes in hepatitis B virus-associated hepatocellular carcinoma. The research results showed that there were differences in the abundance of bacteria in the intestines of patients with B-HCC and NNBNC-HCC, and these bacteria were respectively involved in different functions or biological pathways[11]. Therefore, whether there is HBV infection and whether antiviral treatment is used may have an impact on the changes in the intestinal flora. In the study by Feng J et al., we found that HBV accounted for a high proportion (78.95%) in the HCC population. Based on previous studies, stratified comparison of HCC patients with HBV(+) and HBV(-), as well as recording the use of antiviral drugs and analyzing their effects, can more accurately clarify the microbiota characteristics of HCC itself. All in all, the changes in the gut microbiota are related to the occurrence and development of HCC. The inconsistency in the research on the gut microbiota related to HCC reflects the complexity of the disease and the dynamics of host-microbiota interactions. Future studies need to directly compare the microbiota, metabolome and immune characteristics of patients with HBV(+)HCC and HBV(-)HCC through larger sample cohorts of HCC, and combine animal models to verify the causal mechanism in order to reveal more robust microbiota characteristics and their mechanism of action in the occurrence and development of HCC. We look forward to the author team conducting follow-up research in this direction and promoting the innovation of early diagnosis techniques for HCC. Once again, we thank the authors for their outstanding work, which has opened up new ideas for HCC research. Conflict-of-interest statement: No potential conflicts of interest relevant to this article were reported. 1.Feng J, Wang J P, Hu J R, et al. Multi-omics reveals the associations among the fecal metabolome, intestinal bacteria, and serum indicators in patients with hepatocellular carcinoma[J]. World Journal of Gastroenterology, 2025, 31(15). 2.Zhang L, Wu YN, Chen T, Ren CH, Li X, Liu GX. Relationship between intestinal microbial dysbiosis and primary liver cancer. Hepatobiliary Pancreat Dis Int. 2019 Apr;18(2):149-157. doi: 10.1016/j.hbpd.2019.01.002. Epub 2019 Jan 4. PMID: 30661942. 3.Zhang W, Xu X, Cai L, Cai X. Dysbiosis of the gut microbiome in elderly patients with hepatocellular carcinoma. Sci Rep. 2023 May 13;13(1):7797. doi: 10.1038/s41598-023-34765-w. PMID: 37179446; PMCID: PMC10182990. 4.Yang J, He Q, Lu F, Chen K, Ni Z, Wang H, Zhou C, Zhang Y, Chen B, Bo Z, Li J, Yu H, Wang Y, Chen G. A distinct microbiota signature precedes the clinical diagnosis of hepatocellular carcinoma. Gut Microbes. 2023 Jan-Dec;15(1):2201159. doi: 10.1080/19490976.2023.2201159. PMID: 37089022; PMCID: PMC10128432. 5.Jinato T, Anuntakarun S, Satthawiwat N, Chuaypen N, Tangkijvanich P. Distinct alterations of gut microbiota between viral- and non-viral-related hepatocellular carcinoma. Appl Microbiol Biotechnol. 2024 Dec;108(1):34. doi: 10.1007/s00253-023-12845-1. Epub 2024 Jan 6. PMID: 38183473; PMCID: PMC10771587. 6.Arnold M, Abnet CC, Neale RE, Vignat J, Giovannucci EL, McGlynn KA, Bray F. Global Burden of 5 Major Types of Gastrointestinal Cancer. Gastroenterology. 2020 Jul;159(1):335-349.e15. doi: 10.1053/j.gastro.2020.02.068. Epub 2020 Apr 2. PMID: 32247694; PMCID: PMC8630546. 7.Pan Y, Zhang X. Diet and gut microbiome in fatty liver and its associated liver cancer. J Gastroenterol Hepatol. 2022 Jan;37(1):7-14. doi: 10.1111/jgh.15713. Epub 2021 Nov 3. PMID: 34664301. 8.Zhang X, Coker OO, Chu ES, Fu K, Lau HCH, Wang YX, Chan AWH, Wei H, Yang X, Sung JJY, Yu J. Dietary cholesterol drives fatty liver-associated liver cancer by modulating gut microbiota and metabolites. Gut. 2021 Apr;70(4):761-774. doi: 10.1136/gutjnl-2019-319664. Epub 2020 Jul 21. PMID: 32694178; PMCID: PMC7948195. 9.Shen Y, Wu SD, Chen Y, Li XY, Zhu Q, Nakayama K, Zhang WQ, Weng CZ, Zhang J, Wang HK, Wu J, Jiang W. Alterations in gut microbiome and metabolomics in chronic hepatitis B infection-associated liver disease and their impact on peripheral immune response. Gut Microbes. 2023 Jan-Dec;15(1):2155018. doi: 10.1080/19490976.2022.2155018. PMID: 36519342; PMCID: PMC9757487. 10.Li YG, Yu ZJ, Li A, Ren ZG. Gut microbiota alteration and modulation in hepatitis B virus-related fibrosis and complications: Molecular mechanisms and therapeutic inventions. World J Gastroenterol. 2022 Jul 28;28(28):3555-3572. doi: 10.3748/wjg.v28.i28.3555. PMID: 36161048; PMCID: PMC9372803. 11.Liu Q, Li F, Zhuang Y, Xu J, Wang J, Mao X, Zhang Y, Liu X. Alteration in gut microbiota associated with hepatitis B and non-hepatitis virus related hepatocellular carcinoma. Gut Pathog. 2019 Jan 18;11:1. doi: 10.1186/s13099-018-0281-6. PMID: 30675188; PMCID: PMC6337822. "
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Feng J, Wang JP, Hu JR, Li P, Lv P, He HC, Cheng XW, Cao Z, Han JJ, Wang Q, Su Q, Liu LX. Multi-omics reveals the associations among the fecal metabolome, intestinal bacteria, and serum indicators in patients with hepatocellular carcinoma. World J Gastroenterol 2025; 31(15): 104996
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"The author has provided an interesting study to associate between Epstein-Barr virus and ulcerative colitis with surgery or not. ..."
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"The author has provided an interesting study to associate between Epstein-Barr virus and ulcerative colitis with surgery or not. Meanwhile, the similar virus of Cytomegalovirus also presented a high level in this investigation as data indicated in this study. Maybe author can perform a demonstration to clarify the more connection between the two distinct groups of herpes simplex virus in the development of ulcerative colitis. "
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Zhang H, Gu X, He W, Zhao SL, Cao ZJ. Epstein-Barr virus infection is an independent risk factor for surgery in patients with moderate-to-severe ulcerative colitis. World J Gastroenterol 2025; 31(16): 104758
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"The manuscript 'MicroRNA-155 modulation by renin-angiotensin system inhibitors may underlie their enigmatic role in COVID-19' by ..."
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"The manuscript 'MicroRNA-155 modulation by renin-angiotensin system inhibitors may underlie their enigmatic role in COVID-19' by Konstantinos I Papadopoulos, Alexandra Papadopoulou and Tar Choon Aw addresses the problem of personalized therapy of COVID-19. The authors rightly point out that agents that inhibit the activity of the renin-angiotensin system (RAS), such as angiotensin-converting enzyme inhibitors and AT1R antagonists, can have opposite effects from protective to harmful on the course of the disease, and that worsening of symptoms is seen predominantly in the elderly, in patients with type 2 diabetes, cardiovascular and renal disease, and in some other comorbidities. The authors hypothesise that the negative effects of inhibitors of RAS activity are due to their induced dysregulation of erythropoietin secretion and decreased miRNA-155 levels. The paper cites two references to studies that found a decrease in miRNA-155 following exposure to RAS inhibitors. In conclusion, it is suggested that mineralocorticosteroid receptor antagonists and L-type calcium channel blockers may be preferable to RAS inhibitors in elderly patients and in some comorbidities characterised by reduced baseline miRNA-155 levels. However, a number of the points made by the authors need to be thoroughly tested in further studies, as there is evidence of increased miRNA-155 levels in COVID-19 patients (Asadpour-Behzadi et al, 2023, Haroun et al, 2022), reduced severity of cytokine storm in miRNA-155 knockout animals (Soni et al, 2025) and positive correlation of miRNA-155 levels with inflammatory markers in COVID-19 patients (AL-Nuaimi AL-azzawi, 2025). However, these data do not exclude the possibility that optimal elevation of miRNA-155 levels may be protective, as has been shown in patients with coronary artery disease (Zhu et al., 2014, Ban et al., 2023). Given that miRNA-155 regulates the activity of more than 200 genes, such a non-linear dependence of its effects on levels and physiological characteristics of the organism seems legitimate. The article thus raises a pressing issue that will undoubtedly require further research. "
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Papadopoulos KI, Papadopoulou A, Aw TC. MicroRNA-155 modulation by renin-angiotensin system inhibitors may underlie their enigmatic role in COVID-19. World J Exp Med 2025; 15(2): 100748
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California Corporate Number: 3537345