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Articles In Press
1
Rehman A, Abid M, Jamil H, Siddique S, Parkash S, Nasrullah F, Sapna F, Lohana B, Lohana K, Jawed I, Tufail M, Sharaf MS. Comparative effectiveness of parenteral anticoagulants (fondaparinux, argatroban, bivalirudin) in heparin-induced thrombocytopenia: A systematic review. World J Methodol 2025; In press
2025-12-30 | Browse: 2 | Download: 0
2
Kuang ZY, Qin XY, Wang XM, Song XT, Zhu XY, Li J. Yiqi Wengyang Jiedu prescription promotes disulfidptosis of gastric cancer by reversing senescent cancer-associated fibroblasts. World J Gastrointest Oncol 2025; In press
2025-12-30 | Browse: 0 | Download: 0
3
Chen QX, Zeng WM, Zhang YB, Cai YC, Lv CB, Sun YQ, Cai LS. Preoperative circulating tumor cells as a prognostic indicator in gastric cancer. World J Gastrointest Oncol 2025; In press
2025-12-30 | Browse: 0 | Download: 0
4
Luan WY, Zhang SP, Xu KZ, Shang YH, Hu WJ, Sun H, Miao YD. Microbiota-driven immunometabolic regulation in colorectal cancer: Mechanisms and therapeutic opportunities. World J Gastrointest Oncol 2025; In press
2025-12-30 | Browse: 5 | Download: 0
5
Cantú-Germano E, Moreira L, Pérez-Aisa Á, Martínez-Domínguez SJ, Voynovan I, Bujanda L, Jonaitis L, Tepes B, Garre A, Lucendo AJ, Lerang F, Butler T, Mahmudov U, Huguet JM, Tejedor-Tejada J, Bogomolov P, Beales ILP, Phull PS, Pabon-Carrasco M, Castro-Fernández M, Alekseenko S, Pavoni M, Zaytsev O, Bumane R, Denkovski M, Cajal MD, Tatiana I, Areia M, Keco-Huerga A, Babayeva G, Bermejo F, Simsek H, Buzás GM, Losurdo G, Bordin DS, Kupcinskas J, Smith SM, Gasbarrini A, Leja M, Marcos-Pinto R, Simsek C, Papp V, Rodríguez BJG, Mejide PP, Villarroya RP, Alonso MS, Cano-Català A, Megraud F, O’Morain C, Parra P, Nyssen OP, Gisbert JP. Lack of follow-up in Helicobacter pylori eradication treatment: Results from the European registry on Helicobacter pylori management. World J Gastroenterol 2025; In press
2025-12-30 | Browse: 4 | Download: 0
6
Bai X, Zheng B, Li XM, Wang JD, Huang XH, Fu SM, Chen X. LIM domain only protein 7 promotes metastasis in colorectal cancer by TGF-β/ZEB1 pathway. World J Gastroenterol 2025; In press
2025-12-30 | Browse: 0 | Download: 0
7
Jia YB, Wang J, Guo LK, Ling JH. Traditional Chinese medicine alleviate gastrointestinal symptoms during bismuth quadruple therapy for Helicobacter pylori infection: A complementary perspective. World J Gastroenterol 2025; In press
2025-12-30 | Browse: 4 | Download: 0
8
Maurya P, Gupta A, Gupta N. Influence of blood transfusion on outcomes in patients with gastric cancer. World J Gastroenterol 2025; In press
2025-12-30 | Browse: 0 | Download: 0
9
Umpiérrez NG, Sicco E, Silveira F, Beovide AV, Bologna-Molina R. Differences of immunohistochemical profiling of MOC-31, caveolin-1, connexin-43, Ki-67 in ameloblastic fibroma, ameloblastic fibrodentinoma, ameloblastic fibro-odontoma, and odontomas. World J Exp Med 2025; In press
2025-12-30 | Browse: 6 | Download: 0
10
Kamrul-Hasan ABM, Shaikh S, Ashraf H, Kuchay MS, Nagendra L, Dutta D, Pappachan JM. Safety and efficacy of sodium-glucose cotransporter-2 inhibitors in adults with type 2 diabetes fasting during Ramadan: A meta-analysis. World J Diabetes 2025; In press
2025-12-30 | Browse: 4 | Download: 0
11
Wang RG. Beyond sensitivity and specificity: Redefining the era connotation of “low-risk” in pancreatic cancer screening. World J Clin Oncol 2025; In press
2025-12-29 | Browse: 5 | Download: 0
12
An J, Ahn SH, Kim KH, Heo JY, Yeo MK. Twenty-year temporal trends, risk profiles, and prognostic value of clinicopathological features in gallbladder cancer following cholecystectomy. World J Gastroenterol 2025; In press
2025-12-29 | Browse: 6 | Download: 0
13
Zhang T, Li ZC, Pan ZB, Qi SQ, Tang R. Nomogram-based prediction of post-splenectomy thrombocytosis in children with hereditary spherocytosis. World J Hematol 2025; In press
2025-12-29 | Browse: 2 | Download: 0
14
Zhang XT, Zhu H, Chen XC, Gao T, Chen M, Zhu ZH, Zhang BY, Yu WK. New-onset persistent organ failure predicts adverse outcomes in patients with severe acute pancreatitis. World J Gastroenterol 2025; In press
2025-12-29 | Browse: 2 | Download: 0
15
Rajindrajith S, Hathagoda W, Balakrishnan K, Devanarayana NM. Pharmacological management of childhood constipation: Bridging today’s gaps with tomorrow’s therapies. World J Clin Pediatr 2025; In press
2025-12-29 | Browse: 5 | Download: 0
16
Qi XS, Xie J, Liu NL, Yang L. Relationship between preoperative modified frailty index, immune-inflammation index, and outcomes of colorectal cancer surgery in older patients. World J Gastrointest Oncol 2025; In press
2025-12-29 | Browse: 181 | Download: 11
17
Butler JJ, Hedbany D, Lin CC, Vargas L, Kingery MT, Mercer NP, Lezak BA, Tham A, Rubin J, Kennedy JG. Low return to play and performance in national football league athletes after Achilles tendon rupture: A systematic review. World J Meta-Anal 2025; In press
2025-12-29 | Browse: 3 | Download: 0
18
Zhao T, Jia XR, Li KJ, Zheng WF, Liu XJ. Colitis cystica profunda diagnosed by laparoscopic excision: A case report and review of literature. World J Gastrointest Surg 2025; In press
2025-12-29 | Browse: 1 | Download: 0
19
Uppala PK, Karanam SK, Kandra NV, Edhi S. Rift valley fever: An emerging zoonotic threat to global health and agriculture. World J Virol 2025; In press
2025-12-29 | Browse: 3 | Download: 0
20
Park SB, Kang SB, Seo GS, Eun CS, Choi CH, Yang DH, Park JJ, Moon CM, Jung SH, Park H, Park MH, Yoo HK, Kim J, Heo JA, Park DI. Efficacy and safety of a novel sodium picosulfate oral tablet in a randomized controlled trial for bowel preparation. World J Gastroenterol 2025; In press
2025-12-29 | Browse: 361 | Download: 22
794 items  Read more >>
Author Reviews
1
"Omental torsion (OT) is a rare but significant cause of acute abdomen, frequently masquerading as more common conditions like acute ..."  [Read more]
"Omental torsion (OT) is a rare but significant cause of acute abdomen, frequently masquerading as more common conditions like acute appendicitis. Preoperative diagnosis remains challenging due to nonspecific clinical presentations. This case report aims to reinforce the critical role of modern imaging combined with minimally invasive surgery in achieving timely diagnosis and effective management of this elusive condition. We provide a complete diagnostic circuit—from characteristic CT findings to intraoperative gross pathology and final histopathological confirmation (showing hemorrhage, necrosis, and vascular embolism). This comprehensive documentation deepens the understanding of the disease's progression from vascular torsion to tissue infarction. "  [Collapse]
Li YL, Fan JX, Yang Y, Yao MQ, Jiang YP. Omental torsion diagnosed by abdominal contrast-enhanced computed tomography: A case report. World J Radiol 2025; 17(12): 114398
2
"The review process and the acceptance were both very quick, and I feel that all aspects of the magazine are very well-organized, I ..."  [Read more]
"The review process and the acceptance were both very quick, and I feel that all aspects of the magazine are very well-organized, I am quite satisfied.I will definitely continue to submit articles in the future if there are opportunities.I am very much looking forward to the magazine becoming even better and having higher quality. "  [Collapse]
Wu BQ, Li T, Zhang XD, Jin L. Suturing liver’s round ligament to cystic wall for hepatic cysts. World J Gastrointest Surg 2025; 17(12): 111834
3
"It would be helpful if they could be more flexible with the payment deadline for public institutions in developing countries, such ..."  [Read more]
"It would be helpful if they could be more flexible with the payment deadline for public institutions in developing countries, such as Chile. The process is very slow, and it's impossible to meet the journal's stipulated deadline. However, we appreciate that they didn't halt the process and waited for the payment, which was finally completed after five months. "  [Collapse]
Delgado J, Fuentes M, Simian D, Poniachik J, Urzúa Á. Impact of age on autoimmune hepatitis: A comparative study of patients diagnosed before and after sixty. World J Hepatol 2025; 17(12): 110312
4
"Overall, we are satisfied with the publication process in the World Journal of Hepatology. The editorial team was professional and ..."  [Read more]
"Overall, we are satisfied with the publication process in the World Journal of Hepatology. The editorial team was professional and communication was clear. However, the longest waiting period occurred after the decision that the manuscript was accepted. The time between acceptance and final publication was significantly extended, even after the APC payment was completed. This is an area that could be improved to make the process more efficient. "  [Collapse]
Zeber-Lubecka N, Michalkiewicz J, Dabrowska M, Goryca K, Wierzbicka-Rucińska A, Jańczyk W, Jankowska I, Świąder-Leśniak A, Kubiszewska I, Ziemska-Legięcka J, Socha P, Ostrowski J. Transcriptome profiles of peripheral blood mononuclear cells differentiate male adolescents with non-alcoholic fatty liver disease from healthy peers. World J Hepatol 2025; 17(12): 113359
5
"This journal maintains a consistently high standard of academic rigor. It is well-regarded within its field for publishing innovative ..."  [Read more]
"This journal maintains a consistently high standard of academic rigor. It is well-regarded within its field for publishing innovative research that frequently contributes to significant advancements. The peer-review process is thorough and efficient, ensuring both the quality and timeliness of publications. Editorial boards are comprised of distinguished experts who uphold strict ethical standards. The journal also boasts high production values, with articles being clearly presented and easily accessible. Its strong impact factor and reputation attract submissions from leading researchers worldwide. For authors and readers alike, it is a highly credible and valuable resource for the dissemination of cutting-edge work. "  [Collapse]
Liang ZZ, He JH, Han ZP, Yang XY, Liao LY. Analysis of antinuclear antibody pattern distribution and correlation in patients with colorectal cancer. World J Gastrointest Surg 2025; 17(12): 112038
6
"The authors would like to extend their sincere gratitude to the editorial team for their outstanding professionalism and highly ..."  [Read more]
"The authors would like to extend their sincere gratitude to the editorial team for their outstanding professionalism and highly efficient handling of the manuscript throughout the entire publication process. From the initial assignment and seamless coordination with the reviewers to the final decision, the editorial office maintained clear and timely communication, which ensured a remarkably smooth workflow. We are particularly appreciative of the editor's precise management of the timeline and the exceptional effort in synthesizing the review comments. The constructive and valuable feedback provided has been instrumental in refining our arguments and significantly enhancing the overall quality of the paper. Our sincere thanks go to the editor and all staff involved for their dedicated support and invaluable assistance. "  [Collapse]
Hu YC, Chen XY, Cao MK, Fan Z. Bouveret syndrome in a young patient: A case report and review of literature. World J Gastrointest Surg 2025; 17(12): 113532
7
"The peer review and editorial process were overall constructive and contributed meaningfully to improving the clarity and scientific ..."  [Read more]
"The peer review and editorial process were overall constructive and contributed meaningfully to improving the clarity and scientific quality of the manuscript. Reviewer comments were relevant and helped refine important aspects of the paper. Communication with the editorial office was efficient and professional. I appreciate the efforts of the reviewers and editors in supporting the publication of this work. "  [Collapse]
Karimkhani H. Rheb1 signaling and the fate of pancreatic β cells: Toward a new frontier in diabetes therapy. World J Diabetes 2025; 16(12): 108609
8
"The review process was efficient, and the editorial assistance was commendable. The reviewers provided constructive criticism of our ..."  [Read more]
"The review process was efficient, and the editorial assistance was commendable. The reviewers provided constructive criticism of our manuscript, which significantly enhanced its quality and suitability for the journal. Our responses were well received by both the reviewers and the handling editors, and the editorial team assisted us in preparing the necessary documents in accordance with the journal's requirements. Overall, it was a positive experience. "  [Collapse]
Rajak S, Shahi A, Yadav A, Medhe P, Sinha RA. Microplastics in metabolic dysfunction-associated steatotic liver disease: An emerging threat to liver health. World J Hepatol 2025; 17(12): 111198
9
"The review process was smooth and editorial help was commendable. The reviewer's gave an constructive criticism of our manuscript ..."  [Read more]
"The review process was smooth and editorial help was commendable. The reviewer's gave an constructive criticism of our manuscript which really helped to improve the quality of our manuscript and making it more suitable for the journal. Our response were well received by the reviewer's and the handling editors and the editorial assisted us to prepare the needful documents as per the journal's mandate.Nice experience overall. "  [Collapse]
Singh MM, Shah A, Rajak S, Chaturvedi CP, Sinha RA. Histone lactylation: A key epigenetic modulator in the pathogenesis of metabolic dysfunction-associated steatohepatitis and alcoholic steatohepatitis. World J Hepatol 2025; 17(12): 111153
10
"We sincerely appreciate the World Journal of Nephrology for its transparent, rigorous, and author-friendly publishing process. The ..."  [Read more]
"We sincerely appreciate the World Journal of Nephrology for its transparent, rigorous, and author-friendly publishing process. The peer-review was thorough, fair, and highly constructive, providing valuable insights that significantly strengthened our manuscript. Editorial communication was prompt, professional, and supportive at every stage, from submission to final publication. The journal’s clear guidelines, ethical standards, and commitment to scientific integrity ensured a smooth and efficient experience. We commend the editorial board and reviewers for their dedication to maintaining high academic quality and for facilitating the timely dissemination of clinically relevant nephrology research to the global scientific community. "  [Collapse]
Abbas K, Naqvi R, Musharraf W, Mubarak M, Lal J. Role of antiphospholipid antibodies in kidney disease: Risk factors, immunopathogenesis, and diagnosis. World J Nephrol 2025; 14(4): 110882
11
"Thank you for inviting, reviewing and publishing our article!The manuscript submission and feedback system was quite convenient.We ..."  [Read more]
"Thank you for inviting, reviewing and publishing our article!The manuscript submission and feedback system was quite convenient.We promptly received comments from the editors on all the difficulties and questions that arose, which speeded up the process of reviewing and publication.Despite the difficulties with the list of references, due to the date of publication and the lack of PMID, all questions were promptly resolved and the list of references was promptly adjusted "  [Collapse]
Katchieva PK, Katchieva KK, Kipkeeva FI, Kharaeva ZF, Smeianov VV. Kefir revisited: Insights from the North Caucasus. World J Exp Med 2025; 15(4): 112191
12
"The journal provided a professional and efficient publishing experience, with transparent editorial handling and timely correspondence ..."  [Read more]
"The journal provided a professional and efficient publishing experience, with transparent editorial handling and timely correspondence throughout the submission process.The submission and peer review process was smooth and well structured. The reviewers’ comments were constructive and significantly improved the clarity and scientific quality of the manuscript.The overall publishing experience was highly satisfactory, with clear communication at each stage of the process. "  [Collapse]
Khosla D, Gade VKV, Kapoor R, Singh G, Singh R, Taneja S, Premkumar M, Kalra N, De A, Bhujade H, Verma N, Duseja A, Gupta R. Stereotactic body radiation therapy in patients with unresectable hepatocellular carcinoma and portal vein tumor thrombosis. World J Hepatol 2025; 17(12): 110993
13
"We believe our article will be useful to the reader by offering a different perspective on diverticulitis. Although the publication ..."  [Read more]
"We believe our article will be useful to the reader by offering a different perspective on diverticulitis. Although the publication and review processes in the journal were quite rigorous and sometimes stressful (fear of not meeting the deadline), they yielded positive results. We felt the editors were ready to help at every stage. Everything happen very fast. Thanks for your collaboration. Regards "  [Collapse]
Acar T, Sür Y, Acar N, Tekindal MA, Dilek ON. Does localization change management in complicated right and left-sided diverticulitis? World J Gastrointest Surg 2025; 17(12): 111450
14
"I have been publishing in several journals with Baishideng over the past decade. I have seen them evolving progressively over time. ..."  [Read more]
"I have been publishing in several journals with Baishideng over the past decade. I have seen them evolving progressively over time. They have done a significant upgrade in their submission process. Moreover, they have expanded their journal base while maintaining their quality and efficiency. Their peer review process is efficient and productive. The quality of reviewers has improved significantly and has significantly improved our manuscript. Their editor has been very thorough and patient, working with the authors throughout the process. The copy editing and formatting are excellent. They have even taken effort post publication to spread the work around via RCA It's indeed been a pleasure to get our work and editorial through their platform to scientists globally. "  [Collapse]
Sandhu A, Ailani S, Padte S, Mehta P, Deo N, Surani S, Kashyap R. Skin tone bias in online psoriasis imagery: Insights from an international study. World J Clin Cases 2025; 13(36): 116656
15
"As an author, I am very pleased that our research results have been published in your journal. Looking back on the entire submission ..."  [Read more]
"As an author, I am very pleased that our research results have been published in your journal. Looking back on the entire submission and publication process, I deeply appreciate the professionalism, efficiency, and academic rigor of your team. From the initial submission to the formal online publication, every stage reflected the standardization and meticulousness of your journal's operations. Particularly during the peer review stage, the reviewers provided highly constructive comments; these professional and pertinent suggestions were crucial in enhancing the paper's quality. The editorial office also maintained timely and clear​ communication throughout, efficiently coordinating the review process and offering ample support during the revision stage . Furthermore, I was impressed by your journal's publication speed. The timeframe from manuscript acceptance to online publication was quite reasonable, significantly enhancing the dissemination efficiency of the academic work. Simultaneously, your journal's adherence to an Open Access policy further increased the paper's visibility, providing important convenience for subsequent academic exchange . I sincerely thank the editorial team and the reviewers for their hard work. Your professionalism and author support made me feel respected and assisted throughout this collaboration. I look forward to submitting more high-quality work to your journal in the future and jointly promoting academic progress . "  [Collapse]
Huang Y, Yang XZ, Qin SH, Zhang T, Xie M, Wang JW. Effect of perioperative glutamine-enriched nutritional support on patients with colorectal cancer: A systematic review and meta-analysis. World J Gastrointest Surg 2025; 17(12): 112256
16
"Enjoyed the peer review process, which was efficient and effective. I think the submission system is user friendly, allow for rapid ..."  [Read more]
"Enjoyed the peer review process, which was efficient and effective. I think the submission system is user friendly, allow for rapid communication between the journal and authors. Additionally enjoyed the clear and concise peer review report. Would do this all over again, if given another chance. Congratulations to the F6 publishing systems. Keep up the good work. Kevan English, MD Internal Medicine University of Nebraska Medical Center "  [Collapse]
English K. Drug-induced liver injury from high-dose intravenous methylprednisolone: A rare but known adverse effect. World J Gastrointest Pathophysiol 2025; 16(4): 111306
17
"I am satisfied with the efficiency, transparency, and professionalism demonstrated throughout the submission, review, and decision ..."  [Read more]
"I am satisfied with the efficiency, transparency, and professionalism demonstrated throughout the submission, review, and decision stages. The communication was clear and timely, and the peer-review process was constructive and helpful in improving the quality of the manuscript. The editorial handling was well organized and the guidance provided at each step made the process smooth and straightforward.Thank you for your efforts in maintaining a high standard of academic publishing. I truly appreciate the opportunity to publish with your journal and look forward to future collaborations. "  [Collapse]
Alam R. Atypical presentation of pediatric acute hepatitis A: Is the situation alarming? World J Virol 2025; 14(4): 114174
18
"We are honored to collaborate with your esteemed journal and would like to take this opportunity to express our gratitude to your ..."  [Read more]
"We are honored to collaborate with your esteemed journal and would like to take this opportunity to express our gratitude to your editorial team. Throughout the submission and review process, we were deeply impressed by the professionalism and efficiency of your editorial team, especially in the areas of manuscript review, communication, and revision, where they provided invaluable support and assistance. The clear feedback and meticulous guidance provided at each stage made the entire process smooth and pleasant. At the same time, we highly value your journal's rigorous review and high-quality peer review, which not only enhanced our research level but also allowed us to think more deeply and refine the various aspects of our paper. Overall, we are very satisfied with your service and look forward to more opportunities for collaboration in the future. Thank you again for your efforts and support, and we wish your journal continued success in the academic field. Sincerely,Xuanli "  [Collapse]
Su XL, Xu FR, Yang J, Niu SQ, Shi HJ, He YF, Li ZH, Bagari P, Wu XW, Peng XY, Zhang HW, Wang MY. Calcifying nanoparticles induce apoptosis and calcification in bone marrow mesenchymal stem cells via the transforming growth factor-β/Smad pathway. World J Stem Cells 2025; 17(12): 106128
19
"We sincerely appreciate the opportunity to provide feedback on the journal's peer review process.We believe the current process could ..."  [Read more]
"We sincerely appreciate the opportunity to provide feedback on the journal's peer review process.We believe the current process could be further simplified and shortened to enhance efficiency. Streamlining some redundant procedures would not only reduce the waiting time for authors but also improve the overall submission experience. The peer review reports have been helpful, but a more concise and time-efficient process would better support researchers in advancing their work.We hope these suggestions can contribute to the continuous improvement of the journal's services. "  [Collapse]
Zhang XL, Lin AP, Lin TS, Huang YQ. Effects of early activity intervention on intestinal motility recovery in patients after colorectal cancer surgery. World J Gastrointest Surg 2025; 17(12): 112780
20
"We would like to express our gratitude to the reviewers for their constructive comments on the manuscript. EBV infection is a complex ..."  [Read more]
"We would like to express our gratitude to the reviewers for their constructive comments on the manuscript. EBV infection is a complex issue that can lead to various clinical outcomes. This review examines the distinctions and connections between EBV-related intestinal diseases and IBD. We hope that this paper can be of assistance to clinicians and researchers. "  [Collapse]
Li SY, Jia J, Xu LZ, Zheng K. Relationship between Epstein-Barr virus and inflammatory bowel disease. World J Gastroenterol 2025; 31(48): 111187
20362 items  Read more >>
Article Quality Tracking-Peer-Review
1
"The ethical approval provided by the author meet the requirements. This report provided a rare case report, with educational ..."  [Read more]
"The ethical approval provided by the author meet the requirements. This report provided a rare case report, with educational significance. Of “It is a safe and reliable approach for OT treatment, which offers the advantages of minimal trauma, mild postoperative pain, and rapid recovery for stylistic precision”. It’s not adequate in this section. Of “Abdominal contrast-enhanced CT plays a crucial role in diagnosing OT, and laparoscopic surgery is a safe and effective diagnostic and therapeutic approach” in the conclusion. It’s not adequate to address “and laparoscopic surgery is a safe and effective diagnostic and therapeutic approach” in the “Conclusion”. Structure of relative description was not adequate. Discussion needs not involve much about other aspects of omental torsion other than imaging diagnosis, it should focus on imaging diagnosis and differential diagnosis, especially contrast-enhanced CT and contrast-enhanced ultrasound. Compared to CT, contrast-enhanced CT has higher sensitivity and specificity in the visualization of the omental vascular running and contrast perfusion, and has better ability to determine whether there is ischemia and associate secondary change. “whirlpool sign” is unique for the diagnosis of omental torsion. Duplex ultrasound can find “whirlpool sign” and loss of color signal of vascualrity in some cases of omental torsion. It should be addressed that color Doppler flow imaging is usually not able to detect blood vessels in the great omentum. Contrast-enhanced ultrasound can find defect of vascular perfusion in the region of the great omentum with necrosis, while there was discussion on this technique. It should be addressed that “whirlpool sign” can only be detected in part cases of omental torsion. Ovary torsion has “whirlpool sign” and abdominal emergency, and differential diagnosis is required. The report was written in English awkwardly, not meeting native English and standardized professional expression. Of Figure 1. There were no arrows to indicate “whirlpool sign” of omental torsion. Of “(hematoxylin and eosin, × 50)” in Figure 4. “× 50” does not follow routine practice, and it may be mistaken. "  [Collapse]
Li YL, Fan JX, Yang Y, Yao MQ, Jiang YP. Omental torsion diagnosed by abdominal contrast-enhanced computed tomography: A case report. World J Radiol 2025; 17(12): 114398
2
"This is very interesting paper about the relationship between IBD and Alzheimer’s. Recent studies suggest that patients with IBD ( ..."  [Read more]
"This is very interesting paper about the relationship between IBD and Alzheimer’s. Recent studies suggest that patients with IBD ( UC and chronic ) have a significantly higher about 2.5 times risk of developing dementia,including Alzheimer’s disease and are diagnosed at a younger age. This association may be due to the intestinal inflammation caused by IBD, disruption of intestinal flora and dysfunction of the gut-brain axis sharing a common pathway with the underlying mechanisms of Alzheimer’s disease (such as amyloid beta accumulation),and it is possible that improving the intestinal environment may lead to the prevention of dementia."  [Collapse]
Durairajan SSK, Singh AK, Sulaiman SM, Patnaik S, Krishnamoorthi S, Iyaswamy A, Vellingiri B, Yang CB, Williams LL. Molecular links between inflammatory bowel disease and Alzheimer’s disease through immune signaling and inflammatory pathways. World J Gastroenterol 2025; 31(48): 111301
3
"Bouveret syndrome is a rare form of gallstone ileus, presenting as gastric outlet obstruction due to a large gallstone that has ..."  [Read more]
"Bouveret syndrome is a rare form of gallstone ileus, presenting as gastric outlet obstruction due to a large gallstone that has migrated through a biliogastric or bilioduodenal fistula.This manuscript is a well-written and presented rarely case report.Bouveret Syndrome primarily affects elderly patients. The authors point out that it may also occur in young individuals. I think that this manuscript is worth to publication."  [Collapse]
Hu YC, Chen XY, Cao MK, Fan Z. Bouveret syndrome in a young patient: A case report and review of literature. World J Gastrointest Surg 2025; 17(12): 113532
4
"This study clearly highlights the importance and contribution of AI in the diagnosis of rectal neuroendocrine tumors in daily clinical ..."  [Read more]
"This study clearly highlights the importance and contribution of AI in the diagnosis of rectal neuroendocrine tumors in daily clinical practice. It is known that rectal endocrine tumors present significant diagnostic difficulties because they are often considered as hyperplastic polyps and are either not removed and therefore not subjected to histological evaluation, or are removed as normal polyps. The consequence is that diagnosis is delayed or requires subsequent complementary imaging and/or endoscopic examination. The authors developed an image analysis and detection model for rectal neuroendocrine tumors using the YOLOv7 algorithm. This algorithm demonstrated significant diagnostic accuracy, exceeding that of most endoscopes with which it was compared. It has been repeatedly emphasized that AI is expected to revolutionize the diagnosis of many gastrointestinal diseases, including rectal endocrine tumors. We experience this to a large extent in daily clinical practice. However, it should be emphasized that the effectiveness of this system in detecting neuroendocrine rectal tumors should be investigated and evaluated in future large, multicenter studies."  [Collapse]
Liu K, Wang ZY, Yi LZ, Li F, He SH, Zhang XG, Lai CX, Li ZJ, Qiu L, Zhang RY, Wu W, Lin Y, Yang H, Liu GM, Guan QS, Zhao ZF, Cheng LM, Dai J, Bai Y, Xie F, Zhang MN, Chen SZ, Zhong XF. Artificial intelligence-assisted diagnosis of rectal neuroendocrine tumors during white-light endoscopy. World J Gastroenterol 2025; 31(48): 112683
5
"1. The authors have projected the cardiotoxicity as a sequel of chemotherapy relevant to LMIC in perspective, documenting the follow ..."  [Read more]
"1. The authors have projected the cardiotoxicity as a sequel of chemotherapy relevant to LMIC in perspective, documenting the follow up timings 2. The importance of the follow up and its necessity is also well brought out in the light of current literature 3. The relevance of cardiotoxicity lies in the drug / regime and the dosage. Especially if the patient was administered more than the expected maximal dosage. This can be included for better understanding. "  [Collapse]
Ali W, Mehmood A, Surani S. Chemotherapy-related cardiotoxicity: Bridging the gap between evidence and practice. World J Clin Cases 2025; 13(36): 114228
6
"1. The difference of a squamous cell ca in a viscera, in comparison to that in the superficial skin site can be brought out in terms ..."  [Read more]
"1. The difference of a squamous cell ca in a viscera, in comparison to that in the superficial skin site can be brought out in terms of presentation, prognosis / management / tumor behaviour, etc 2. When to suspect a similar lesion can be highlighted for the benefit of readers 3. The conclusion section can avoid summary of the manuscript, rather can include a crisp take home message on the index case."  [Collapse]
Li QQ, Wei J, Fang LY, Zhou JL, Zhao HF. Primary ileal squamous cell carcinoma: A case report and review of literature. World J Clin Cases 2025; 13(36): 111835
7
"The article entitled Evolving trends in hepatitis A epidemiology: Shifting patterns, emerging risks, and future strategies is well ..."  [Read more]
"The article entitled Evolving trends in hepatitis A epidemiology: Shifting patterns, emerging risks, and future strategies is well written article but some comments to be considered: - Most of the studies included in the review article depend on seroprevalence of the disease that is mean it depend on detection of antibodies which of course of low speceficity as diagnosis of HAV infection must depend on isolation of the virus by real time PCR especially in endemic areas to avoid false positive results. - There is some redunduncy and reptition of the data (e.g Endemicity in the era of vaccination and improving living standards -- Changing epidemiology of hepatitis A "  [Collapse]
Majeed AA, Sarfraz M, Butt AS. Evolving trends in hepatitis A epidemiology: Shifting patterns, emerging risks, and future strategies. World J Virol 2025; 14(4): 112590
8
" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..."  [Read more]
" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."  [Collapse]
Huang K. Influence of obesity on the patient’s recovery after laparoscopic surgery. World J Clin Cases 2025; 13(36): 115269
9
" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..."  [Read more]
" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."  [Collapse]
Taha R, Elsayed G, Mohamed L, Gadour E. Beyond biliary causes, fish bone perforation as a rare etiology of recurrent fever in a post-Whipple patient: A case report. World J Clin Cases 2025; 13(36): 114956
10
" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..."  [Read more]
" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."  [Collapse]
Li QQ, Wei J, Fang LY, Zhou JL, Zhao HF. Primary ileal squamous cell carcinoma: A case report and review of literature. World J Clin Cases 2025; 13(36): 111835
11
"In this study, the authors describe a patient with severe ulcerative colitis resistant to treatment and comorbid health problems who ..."  [Read more]
"In this study, the authors describe a patient with severe ulcerative colitis resistant to treatment and comorbid health problems who responded favorably and without side effects to the combined treatment of an α4β7 integrin antagonist (vedolizumab) and an interleukin 23p19 inhibitor (mirikizumab). This case reinforces the view, expressed over the last few years, of the need to combine two biological agents in treatment-resistant inflammatory bowel disease and in treatment-resistant patients with extraintestinal manifestations. Personally, I believe we will be led to adopt the above recommendation in the near future. What remains is the approval and adoption of this recommendation by the pharmaceutical companies manufacturing biological agents, so they can conduct extensive, multicenter studies and avoid being limited to descriptions of individual cases or series from specialized centers with very small patient numbers."  [Collapse]
Guimarães AC, Ferreiro-Iglesias R, Calviño-Suarez C, Baston-Rey I, Barreiro-de Acosta M. Dual biologic therapy in patient with refractory ulcerative colitis and comorbidities: A case report. World J Gastroenterol 2025; 31(47): 113381
12
"1 Ethics: Does the ethical approval form provided by the author meet the requirements? Not applicable. 2 Methods: Is the ..."  [Read more]
"1 Ethics: Does the ethical approval form provided by the author meet the requirements? Not applicable. 2 Methods: Is the experimental method effective? Can it be repeated by fellow researchers (according to adequate textual/citation content presented)? Not applicable. 3 Results: Are the results true and authentic? Is the theory or hypothesis of universal significance validated or partially validated? Not applicable. 4 Figures and tables: Does the author provide perfect tables, line charts and/or graphs? Or, does the author provide figures and tables that are confusing, poorly constructed and/or not well-annotated? Yes. 5 Biostatistics: Does the author provide perfect biostatistics data? Or, does the author provide tables and line charts that have mistakes in the data? Not applicable. 6 References: Does the author scientifically and reasonably cite the latest references which are important in this field and related to the scientific problems and research hypotheses addressed in the study? Or, does the author self-cite, omit, mis-cite and/or over-cite references? Yes. 7 Language: Does the language in article correctly, clearly and concisely express the information? Or, does the article have multiple grammatical and spelling mistakes? Yes. 8 Caveats or drawbacks: What are the caveats or drawbacks for the results? They didn't provide many new ideas."  [Collapse]
Li H, Li ZP, Zhu MT, Lan CH, Wang YX, Liao P, Chen Z, Wang P, Sun JK, Shi Z, Lu PY, Lou C, Xu GH. Optimizing mesenchymal stem cell therapy for tendon-bone healing: Multifaceted approaches and future directions. World J Stem Cells 2025; 17(12): 114076
13
"These findings illuminate the pivotal role of YY1 in driving the progression of Helicobacter pylori-induced gastric carcinogenesis ..."  [Read more]
"These findings illuminate the pivotal role of YY1 in driving the progression of Helicobacter pylori-induced gastric carcinogenesis through the activation of epithelial-mesenchymal transition (EMT). From a molecular vantage point, this study stands as a compelling testament to rigorous scientific inquiry, underpinned by a wealth of robust experimental evidence that substantiates its central claims. Here I only offer a suggestion and reference. In fact, cancer is a complex pathological ecosystem rather than a simple genetic disease. However, the current mainstream research perspective is greatly influenced by the "somatic mutation" theory, often believing that genes and molecules are the ultimate essence of cancer. However, such a linear reductionist view has not brought about fundamental improvements in prognosis in clinical practice, such as in targeted therapy. I believe that in the post-genomic era, we should think more about the occurrence and development of cancer from the perspectives of ecology and evolution rather than being confined to the molecular level. As I pointed out in the "Rethinking Cancer" column for the 110th anniversary of the Chinese Medical Association (https://pubmed.ncbi.nlm.nih.gov/40443342/), the key to understanding such a complex systemic disease as tumors does not lie in the relentless pursuit of genes and molecules. It can be said that the role and function (promoting or inhibiting cancer, driver, passenger or neutral) of a single gene mutation in cancer cells depend on the environment and ecological niche in which they are located. By the way, I kindly recommend the authors and your team explore the book "Rethinking Cancer" (Strauss B. et al., 2021), which is also available in Chinese version (2024, Tsinghua University Press). This book might offer a refreshing and insightful perspective on human cancers, which could help guide future research and practice and better assist in improving patient prognosis."  [Collapse]
Chen JW, Ouyang JJ, Wang ZH, Ma DM, Zhang Z, Teng Q, Yu G, Li XY. Yin Yang 1 activates JAK-STAT3-mediated epithelial-mesenchymal transition in Helicobacter pylori-induced gastric cancer progression. World J Clin Oncol 2025; 16(12): 112626
14
"This is very interesting paper. The authors state that the Bismuth-Corlett classification, hypokalemia, and AST levels were identified ..."  [Read more]
"This is very interesting paper. The authors state that the Bismuth-Corlett classification, hypokalemia, and AST levels were identified as independent risk factors for PBI following ERCP drainage. The Bismuth-Corlett classification and AST levels can be understood as risk factors for drainage infection after ERCP, but please explain why hypokalemia is a risk factor. Please state in numbers how much hypokalemia is and what the AST level is."  [Collapse]
Wang YF, Han K, An N, Sun YN, Gao F, Sun Y, Zhang D, Zhao ZF, Guo Q, Gu JN, Yang Z. Risk prediction of biliary infection after endoscopic drainage for malignant perihilar biliary obstruction: A 10-year multicenter retrospective study. World J Gastroenterol 2025; 31(47): 113156
15
"The study is particularly strong in its development of a multimodal fusion model that integrates clinical data, radiomics, and habitat ..."  [Read more]
"The study is particularly strong in its development of a multimodal fusion model that integrates clinical data, radiomics, and habitat imaging to achieve markedly superior performance in predicting early recurrence of hepatocellular carcinoma, outperforming traditional single‑modality models in both accuracy and clinical net benefit. It also excels by incorporating SHAP‑based interpretability to clarify how specific imaging and clinical features contribute to predictions, and by validating meaningful correlations between selected radiomic/habitat features and key pathological markers such as MVI, Ki‑67, and GPC‑3, thereby enhancing biological plausibility and clinical relevance."  [Collapse]
Huang LH, Fang YJ, Zheng XJ, Huang C, Li CL, Yu B, Huang MJ, Qin SJ, Huang DY, Lu DW. Application of multimodal fusion technology in early recurrence prediction and pathological analysis of hepatocellular carcinoma. World J Gastrointest Oncol 2025; 17(12): 114037
16
"The study excels by integrating radiomics and body composition metrics from both pretreatment and follow‑up T12‑level CT scans, ..."  [Read more]
"The study excels by integrating radiomics and body composition metrics from both pretreatment and follow‑up T12‑level CT scans, demonstrating that combining these imaging biomarkers with clinical data markedly improves the accuracy of survival prediction in esophageal cancer. It also stands out for using automated segmentation tools to eliminate manual variability, rigorously comparing multiple machine‑learning models, and showing that follow‑up imaging adds substantial prognostic value. Overall, the research provides a practical, non‑invasive, and clinically applicable framework that enhances personalized risk stratification when traditional L3‑level imaging is unavailable."  [Collapse]
Liu MC, Cheng YY, Lin SC, Lin CH, Chuang CY, Chen WH, Liao CH, Hsieh CH, Hsieh MF, Liu YJ. Machine learning survival prediction in esophageal cancer using radiomics and body composition from pretreatment and follow-up T12-level computed tomography. World J Gastrointest Oncol 2025; 17(12): 112873
17
"The study demonstrates several strengths, including the safe and smooth execution of cryoablation without perioperative deaths, the ..."  [Read more]
"The study demonstrates several strengths, including the safe and smooth execution of cryoablation without perioperative deaths, the clear improvement in immune function and pain reduction following treatment, and the meaningful clinical benefits such as tumor shrinkage and prolonged overall survival compared with chemotherapy alone; together, these findings highlight cryoablation as an effective, minimally invasive option that enhances quality of life and offers a promising therapeutic alternative for patients with locally advanced pancreatic cancer."  [Collapse]
Kang LM, He XL, Lang L, Wang AY, Wang X, Liu YH, Zhao YH, Xu L, Yu FK, Zhang FW. Safety and efficacy of cryoablation in treating locally advanced pancreatic cancer. World J Gastrointest Oncol 2025; 17(12): 113387
18
"The study evaluated a WeChat‑based bowel preparation monitoring system for outpatients undergoing colonoscopy and found that, compared ..."  [Read more]
"The study evaluated a WeChat‑based bowel preparation monitoring system for outpatients undergoing colonoscopy and found that, compared with traditional oral and written education, the digital system significantly reduced patients’ anxiety and depression, improved bowel cleanliness, enhanced key colonoscopy quality indicators such as cecal intubation rate and polyp detection rate, increased patient compliance with dietary and medication instructions, and lowered the incidence of adverse reactions, demonstrating that real‑time, interactive, and personalized guidance can meaningfully improve the overall effectiveness and safety of colonoscopy preparation."  [Collapse]
Xi MJ, Gong YP, Tao J, Li F, Xu MY, Gu X, Bao H, Jiang S, Xu B. Exploring the improvement effect of intestinal network monitoring system on intestinal preparation quality of colonoscopy. World J Gastrointest Oncol 2025; 17(12): 111101
19
"The article provides a rigorous and comprehensive meta‑analysis evaluating the prognostic significance of cancer‑associated fibroblasts ..."  [Read more]
"The article provides a rigorous and comprehensive meta‑analysis evaluating the prognostic significance of cancer‑associated fibroblasts in liver cancer using real‑world clinical data. It strengthens its conclusions through well‑structured subgroup analyses across different CAF markers and cancer types, offering a more nuanced understanding of their prognostic value. The study also adheres to PRISMA guidelines and includes only high‑quality research, enhancing the reliability and credibility of its findings."  [Collapse]
Wei YH, Jiang WJ, Wang SQ, Cai YL, Ma XL. Cancer-associated fibroblasts, clinicopathological characteristics and prognosis of liver cancer: A systematic review and meta-analysis based on real-world research. World J Gastrointest Oncol 2025; 17(12): 110395
20
"It was with pleasure that I reviewed the article quality of the following manuscript: 1 Ethics: Not applicable given manuscript ..."  [Read more]
"It was with pleasure that I reviewed the article quality of the following manuscript: 1 Ethics: Not applicable given manuscript type 2 Methods: Not applicable given manuscript type 3 Results: Not applicable given manuscript type 4 Figures and tables: Not applicable - non included 5 Biostatistics: Not applicable given manuscript type 6 References: References are appropriate/up to date 7 Language: Concise/well written manuscript 8 Caveats or drawbacks: None "  [Collapse]
Turan B. Prognostic impact of tumor deposits in colorectal cancer. World J Gastroenterol 2025; 31(47): 114506
15890 items  Read more >>
Peer-Reviewers and Manuscript Statistics
Editorial board members
2264
Peer-reviewers
35352
Manuscripts received today
27
Manuscript reviews today
44
Unhandled manuscripts today
163
Active peer-reviewers today
2634
Reviewer acceptance today
50
Reviewer refusals today
76
Total accepted manuscripts
39312
Total rejected manuscripts
44155
Total peer-reviewers
4609153
Total submissions
37360
Baishideng Publishing Group (BPG) publishes 47 peer-reviewed, open-access journals covering a broad range of topics in clinical medicine, as well as several topics in biochemistry and molecular biology, relevant to human health today.
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All Journal Articles
1

Triantafyllou G, Papadopoulos-Manolarakis P, Arkoudis NA, Moschovaki-Zeiger O, Velonakis G, Piagkou M. Magnetic resonance imaging-based classification of trigeminal nerve-superior cerebellar artery relationships. World J Radiol 2025; 17(12): 116453

2025-12-28 | Browse: 199 | Download: 78
2

Centini FR, Fedorov D, Perera Molligoda Arachchige AS. Radiologists’ perspectives on the use of artificial intelligence in emergency radiology: A pilot survey. World J Radiol 2025; 17(12): 115388

2025-12-28 | Browse: 194 | Download: 81
3

Wang CL, Zeng M, Luo Y. Unmasking the high-risk phenotype in autoimmune gastritis: A pathologist’s roadmap for the clinician. World J Gastroenterol 2025; 31(48): 115244

2025-12-28 | Browse: 127 | Download: 59
4

Bouayad A. Harnessing early enzymatic biomarkers and cytokines for risk prediction in post-endoscopic retrograde cholangiopancreatography pancreatitis. World J Gastroenterol 2025; 31(48): 114786

2025-12-28 | Browse: 166 | Download: 65
5

Hua HW, Wu J. Transverse incision with longitudinal ligation procedure: Innovation, pitfalls, and clinical perspectives. World J Gastroenterol 2025; 31(48): 114738

2025-12-28 | Browse: 109 | Download: 52
6

Arkoudis NA, Siderakis M, Tsetsou I, Efthymiou E, Triantafyllou G, Chalmoukis D, Karachaliou A, Papadopoulos A, Prountzos S, Moschovaki-Zeiger O, Gouliopoulos N, Papakonstantinou O, Filippiadis D, Velonakis G. Developmental venous anomalies and cerebral cavernous malformations: Partners in crime. World J Radiol 2025; 17(12): 114595

2025-12-28 | Browse: 302 | Download: 74
7

Li YL, Fan JX, Yang Y, Yao MQ, Jiang YP. Omental torsion diagnosed by abdominal contrast-enhanced computed tomography: A case report. World J Radiol 2025; 17(12): 114398

2025-12-28 | Browse: 162 | Download: 72
8

Kritzinger J, Candel I, Kotrri G, Nadeem H, Afif W, Bitton A, Wild G, Bessissow T, Lakatos PL. Clinical outcomes and drug sustainability after non-medical switch from ustekinumab originator to biosimilars in inflammatory bowel disease. World J Gastroenterol 2025; 31(48): 114355

2025-12-28 | Browse: 193 | Download: 69
9

Sathish S. Thermal field management in thyroid ablation for papillary thyroid carcinoma: Advancing precision and patient-centered care. World J Radiol 2025; 17(12): 114211

2025-12-28 | Browse: 157 | Download: 63
10

Zhao BK, Li Y, Jiang YY, Li ML, Jiang Y, Zhu L, Guo CN, Liu SH, Chen L, Jiang LN, Niu JQ, Zhao JM. Clinical, pathological characteristics and long-term outcomes of hepatitis B virus related cirrhosis in pediatric observational study. World J Gastroenterol 2025; 31(48): 114049

2025-12-28 | Browse: 146 | Download: 66
11

Zhang X, Liao MJ, Ren LY, Qin WY, Mu SW, She SP, Fei R, Cong X, Zhou YP, Chen DB, Chen HS. AADN score: Predicting response to transarterial chemoembolization, sintilimab and lenvatinib in patients with hepatocellular carcinoma. World J Gastroenterol 2025; 31(48): 113856

2025-12-28 | Browse: 194 | Download: 81
12

Xia CC, Xu Y, Wang ZH, Xu GQ. Mitochondrial dysfunction as a bridge to pathology in acute pancreatitis: From molecular insights to novel therapeutic strategies. World J Gastroenterol 2025; 31(48): 113840

2025-12-28 | Browse: 167 | Download: 68
13

Giangregorio F. Capecitabine maintenance after radiofrequency ablation: A preventive strategy for lung oligometastases from colorectal cancer. World J Gastroenterol 2025; 31(48): 113550

2025-12-28 | Browse: 105 | Download: 47
14

Sun SP, Mao YQ, Fan YH, Lv B. Exploring exercise modalities and their impact on inflammatory bowel disease: A systematic review of rodent colitis models. World J Gastroenterol 2025; 31(48): 113243

2025-12-28 | Browse: 244 | Download: 66
15

Majeed AA, Butt AS. Gut microbiota: An overlooked target in dyslipidemia management. World J Gastroenterol 2025; 31(48): 113178

2025-12-28 | Browse: 266 | Download: 54
16

Sharma A, Subramanian P, Soundararajan R, Maralakunte M, Mallick A, Debi U, Jaswal V, Manoj Kumar R, Singhal M. Imaging considerations in tetralogy of Fallot: A comprehensive review. World J Radiol 2025; 17(12): 112986

2025-12-28 | Browse: 169 | Download: 65
17

Wang Y, Ma GH, Qu MY, Xu QS, Huang HX. Serum uric acid-to-high-density lipoprotein cholesterol ratio and cardiovascular risk in Asian patients with metabolic dysfunction-associated steatotic liver disease. World J Gastroenterol 2025; 31(48): 112972

2025-12-28 | Browse: 159 | Download: 83
18

Shi Y, Zhang P, Li L, Yang HM, Li ZM, Zheng J, Yang L. Interpretable model based on multisequence magnetic resonance imaging radiomics for predicting the pathological grades of hepatocellular carcinomas. World J Radiol 2025; 17(12): 112911

2025-12-28 | Browse: 184 | Download: 77
19

Liu K, Wang ZY, Yi LZ, Li F, He SH, Zhang XG, Lai CX, Li ZJ, Qiu L, Zhang RY, Wu W, Lin Y, Yang H, Liu GM, Guan QS, Zhao ZF, Cheng LM, Dai J, Bai Y, Xie F, Zhang MN, Chen SZ, Zhong XF. Artificial intelligence-assisted diagnosis of rectal neuroendocrine tumors during white-light endoscopy. World J Gastroenterol 2025; 31(48): 112683

2025-12-28 | Browse: 188 | Download: 86
20

Zakharzhevskaya NB, Erdes SI, Belousova EA, Samolygo IS, Manina MA, Kondrashova PV, Lomakina EY, Kardonsky DA, Vorobyeva EA, Shagaleeva OY, Silantyev AA, Kazakova VD, Kashatnikova DA, Kalachnuk TN, Kolesnikova IV, Chaplin AV, Markelova MI, Grigoryeva TV, Olekhnovich EI, Veselovsky VA, Morozov MD, Zoruk PY, Boldyreva DI, Vanyushkina AA, Efimov BA. Combined metabolomic and metagenomic analysis reveals inflammatory bowel disease diversity in pediatric and adult patients. World J Gastroenterol 2025; 31(48): 112653

2025-12-28 | Browse: 243 | Download: 82
61568 items  Read more >>
Featured Articles
1

Zhao BK, Li Y, Jiang YY, Li ML, Jiang Y, Zhu L, Guo CN, Liu SH, Chen L, Jiang LN, Niu JQ, Zhao JM. Clinical, pathological characteristics and long-term outcomes of hepatitis B virus related cirrhosis in pediatric observational study. World J Gastroenterol 2025; 31(48): 114049

2025-12-27 | Browse: 29 | Download: 28
2

Zhang X, Liao MJ, Ren LY, Qin WY, Mu SW, She SP, Fei R, Cong X, Zhou YP, Chen DB, Chen HS. AADN score: Predicting response to transarterial chemoembolization, sintilimab and lenvatinib in patients with hepatocellular carcinoma. World J Gastroenterol 2025; 31(48): 113856

2025-12-27 | Browse: 21 | Download: 26
3

Liu K, Wang ZY, Yi LZ, Li F, He SH, Zhang XG, Lai CX, Li ZJ, Qiu L, Zhang RY, Wu W, Lin Y, Yang H, Liu GM, Guan QS, Zhao ZF, Cheng LM, Dai J, Bai Y, Xie F, Zhang MN, Chen SZ, Zhong XF. Artificial intelligence-assisted diagnosis of rectal neuroendocrine tumors during white-light endoscopy. World J Gastroenterol 2025; 31(48): 112683

2025-12-27 | Browse: 20 | Download: 25
4

Li SY, Jia J, Xu LZ, Zheng K. Relationship between Epstein-Barr virus and inflammatory bowel disease. World J Gastroenterol 2025; 31(48): 111187

2025-12-27 | Browse: 21 | Download: 22
5

Bouayad A. Harnessing early enzymatic biomarkers and cytokines for risk prediction in post-endoscopic retrograde cholangiopancreatography pancreatitis. World J Gastroenterol 2025; 31(48): 114786

2025-12-27 | Browse: 19 | Download: 21
6

Zeng FL, Shi MJ, Mo YS, Xiao HM, Xie YB, Chi XL. He-He-Shu-Yang formula alleviates liver fibrosis by inhibiting hepatic stellate cell activation in vivo and in vitro. World J Hepatol 2025; 17(12): 112835

2025-12-26 | Browse: 20 | Download: 36
7

Lucas IC, Domingues AL, Filgueira NA, Lopes EP, Alburquerque IKP, Pereira CLD. Minimal hepatic encephalopathy in hepatosplenic schistosomiasis: High prevalence and association with portosystemic shunts in a Brazilian cross-sectional study. World J Hepatol 2025; 17(12): 113078

2025-12-26 | Browse: 16 | Download: 25
8

Delgado J, Fuentes M, Simian D, Poniachik J, Urzúa Á. Impact of age on autoimmune hepatitis: A comparative study of patients diagnosed before and after sixty. World J Hepatol 2025; 17(12): 110312

2025-12-26 | Browse: 18 | Download: 22
9

Valamparampil J, Brown RM, Mckiernan P. Refractory autoimmune hepatitis in children: Considerations for assessment and management. World J Hepatol 2025; 17(12): 110966

2025-12-26 | Browse: 15 | Download: 15
10

Giannitrapani L, Ferraro M, Seidita A, Licata A, Soresi M. Interplay between intestinal permeability and metabolic dysfunction-associated steatotic liver disease: Could there be a role for extra virgin olive oil consumption? World J Hepatol 2025; 17(12): 110076

2025-12-26 | Browse: 16 | Download: 19
11

Li YL, Fan JX, Yang Y, Yao MQ, Jiang YP. Omental torsion diagnosed by abdominal contrast-enhanced computed tomography: A case report. World J Radiol 2025; 17(12): 114398

2025-12-26 | Browse: 18 | Download: 19
12

Triantafyllou G, Papadopoulos-Manolarakis P, Arkoudis NA, Moschovaki-Zeiger O, Velonakis G, Piagkou M. Magnetic resonance imaging-based classification of trigeminal nerve-superior cerebellar artery relationships. World J Radiol 2025; 17(12): 116453

2025-12-26 | Browse: 17 | Download: 20
13

Shi Y, Zhang P, Li L, Yang HM, Li ZM, Zheng J, Yang L. Interpretable model based on multisequence magnetic resonance imaging radiomics for predicting the pathological grades of hepatocellular carcinomas. World J Radiol 2025; 17(12): 112911

2025-12-26 | Browse: 17 | Download: 23
14

Sathish S. Thermal field management in thyroid ablation for papillary thyroid carcinoma: Advancing precision and patient-centered care. World J Radiol 2025; 17(12): 114211

2025-12-26 | Browse: 17 | Download: 30
15

Sharma A, Subramanian P, Soundararajan R, Maralakunte M, Mallick A, Debi U, Jaswal V, Manoj Kumar R, Singhal M. Imaging considerations in tetralogy of Fallot: A comprehensive review. World J Radiol 2025; 17(12): 112986

2025-12-26 | Browse: 19 | Download: 21
16

El-Imam IA, Peter TA, Fussi HF, Ally ZM, Bakari HM, Mbwana MS, Chenya UK, Mpimo BK, Ally HM, Ramadhani HO. Human immunodeficiency virus recency testing coverage and partner-notification-services among people-living with human immunodeficiency virus in low- and middle-income countries. World J Virol 2025; 14(4): 111810

2025-12-25 | Browse: 31 | Download: 68
17

Block SJ, Ibrahim Y, Cohen C. Adherence to antiviral treatment among people living with chronic hepatitis B: A global survey. World J Virol 2025; 14(4): 110951

2025-12-25 | Browse: 29 | Download: 58
18

Fernando TN, Dayananda D, Muthugala R. Human bocavirus: As an emerging respiratory pathogen. World J Virol 2025; 14(4): 115043

2025-12-25 | Browse: 31 | Download: 53
19

Zeppieri M, Capobianco M, Avitabile A, Visalli F, Mazzotta C, Musa M, Giglio R, Tognetto D, Gagliano C, Cappellani F. Viral eye: Emerging insights into corneal and ocular surface viral infections. World J Virol 2025; 14(4): 113449

2025-12-25 | Browse: 27 | Download: 46
20

Zohery M, Jahangir S, Jenna HC, Sarfraz S, Ali H, Raza M, Rafiq T, Dahiya DS, Jahagirdar V, Ali H. Thrombotic risk in hepatitis C: Interplay between hepatic dysfunction, viral-driven inflammation, and cardiovascular consequences. World J Virol 2025; 14(4): 113217

2025-12-25 | Browse: 30 | Download: 50
10262 items  Read more >>
Keyword Search Published Articles Processes
1
Case report
2854
2
Case report
1867
3
Hepatocellular carcinoma
1481
4
Gastric cancer
1049
5
Colorectal cancer
1025
6
Inflammatory bowel disease
732
7
COVID-19
709
8
Prognosis
671
9
Liver transplantation
635
10
Ulcerative colitis
566
11
Treatment
552
12
Helicobacter pylori
528
13
Crohn’s disease
522
14
Diagnosis
517
15
Endoscopy
482
16
Cirrhosis
481
17
Meta-analysis
456
18
Pancreatic cancer
452
19
Magnetic resonance imaging
442
20
Surgery
424
74589 items  Read more >>
Reader Comments
1
"I read the excellent paper by Rajak et al. The review is organized and precisely addresses the role of microplastics in inducing ..."  [Read more]
"I read the excellent paper by Rajak et al. The review is organized and precisely addresses the role of microplastics in inducing metabolic-associated steatotic liver disease and its progression. The review raises a growing emergency: the relationship between air pollution and human health. This can be a stimulus for policymakers and international organizations to take concrete action. However, it should be remembered that a proper lifestyle can mitigate the negative impact of microplastics on the liver and human health in general. While waiting for long-term measures, this is information that can yield short-term results. On this issue, it will be my concern to send a letter to the editor. Sincerely, Gianni Testino "  [Collapse]
Rajak S, Shahi A, Yadav A, Medhe P, Sinha RA. Microplastics in metabolic dysfunction-associated steatotic liver disease: An emerging threat to liver health. World J Hepatol 2025; 17(12): 111198
2
"1.The article does not cover the temporal and spatial dynamic changes of inflammatory cytokines during the development of NSCLC, as ..."  [Read more]
"1.The article does not cover the temporal and spatial dynamic changes of inflammatory cytokines during the development of NSCLC, as well as how these changes affect the occurrence and development of drug resistance. For instance, are there any differences in the expression levels of inflammatory cytokines in the early stage, progression stage, and resistance stage of the tumor? Are their distributions different in various parts of the tumor (such as the primary lesion and metastatic lesion)? It is suggested to utilize techniques such as in situ hybridization and immunohistochemistry, combined with single-cell sequencing and spatial transcriptomics, to study the temporal and spatial dynamic changes of inflammatory cytokines in different development stages and different locations of NSCLC. By analyzing longitudinal samples of patients (such as before treatment, during treatment, and after resistance), the dynamic change patterns of inflammatory cytokines during the process of drug resistance can be revealed. 2. Although IL-6R blockade shows the effect of reversing drug resistance, single-target therapy may have limitations in efficacy or the risk of drug resistance escape. It is suggested to explore IL-6/IL-8 dual-target inhibition in preclinical models, or to combine it with downstream pathway inhibitors (such as JAK/STAT, PI3K/AKT, NF-κB inhibitors) or immune checkpoint inhibitors to evaluate its synergistic anti-tumor effect and its remodeling effect on the tumor microenvironment, in order to provide theoretical basis for future clinical trials of combination therapy. "  [Collapse]
Calibasi-Kocal G. Inflammatory cytokine-associated cisplatin resistance in non-small cell lung cancer and re-sensitization through interleukin-6 receptor blockade. World J Clin Oncol 2025; 16(12): 114275
3
"Author: Priya Hazrah Professor, Department of Surgery, Lady Hardinge Medical College, New Delhi. Email: priyahazrah@gmail.com, ORCID ..."  [Read more]
"Author: Priya Hazrah Professor, Department of Surgery, Lady Hardinge Medical College, New Delhi. Email: priyahazrah@gmail.com, ORCID ID 0009-0008-1915-3978 Deborshi Sharma Director Professor Department of Surgey ABVIMS, New Delhi. Email: drdeborshi@gmail.com, ORCID ID 0000-0001-8251-8484 Sonali Mittal Assistant professor, Lady Hardinge Medical College, New Delhi Email: sonali.prachi@gmail.com, ORCID 0000-0002-6289-7656 Corresponding Author: Priya Hazrah Professor Department of Surgery, Lady Hardinge Medical College, New Delhi. Email: priyahazrah@gmail.com We read with tremendous interest your article entitled “Mastering the third space: Innovations in intramural endoscopic surgery for gastrointestinal disorders.” It was a very apt and concise review of commonly performed third space endoscopy (TSE) procedures, namely the C, Z, E, and G POEM (per oral endoscopic myotomy). Here, we would like to highlight other evolving procedures related to third space endoscopy and also the emerging concept of “fourth space endoscopy.” POETRE, peroral esophageal tunnelling for restoration of the esophagus, based on the principle of TSE, is an innovative technique of submucosal tunnelling proposed to be a useful therapeutic option in long-segment complete esophageal luminal obstruction in a few case series [1, 2]. PREM/PAEM (per rectal/per anal myotomy) is another novel use of TSE with limited exploration in patients with Hirschsprung’s disease [3]. STER (submucosal tunnelling endoscopic resection) and POET (peroral endoscopic excision of tumor) have been reported to be safe procedures for resection of extramucosal tumors in the upper gastrointestinal tract with acceptable complication rates vouched for in recent meta-analyses [4-7]. Further, TSE can be used to gain peritoneal access, as seen in POEM+F (POEM with fundoplication). Building upon the model of third space endoscopy is a forthcoming concept of fourth space endoscopy based on the technique of sub-serosal dissection for excision of extramucosal tumors in the upper gastrointestinal tract, like gastrointestinal stromal tumors, leiomyoma, hamartoma, etc., published in a limited case series [8]. The feasibility of using the principle of the fourth-space endoscopy procedure for vagotomy is investigational and has been reported currently in an anecdotal non-human study [9]. The fourth space is also utilized at times in POEM to enable a full-thickness myotomy [10]. References 1. Wagh MS, Draganov PV. Per-oral endoscopic tunneling for restoration of the esophagus: a novel endoscopic submucosal dissection technique for therapy of complete esophageal obstruction. Gastrointest Endosc. 2017 Apr;85(4):722-727. doi: 10.1016/j.gie.2016.08.035. Epub 2016 Sep 7. PMID: 27612924. 2. Félix C, Barreiro P, Rodrigues Azevedo J, Maia L, Küttner-Magalhães R, Pedroto I, Chagas C. Per-oral endoscopic tunneling for restoration of the esophagus (POETRE) in the management of a complete esophageal obstruction. Endosc Int Open. 2021 Jul;9(7):E1084-E1085. doi: 10.1055/a-1463-3059. Epub 2021 Jun 17. PMID: 34222634; PMCID: PMC8211479. 3. Bapaye A, Dashatwar P, Biradar V, Biradar S, Pujari R. Initial experience with per-rectal endoscopic myotomy for Hirschsprung's disease: medium and long term outcomes of the first case series of a novel third-space endoscopy procedure. Endoscopy. 2021 Dec;53(12):1256-1260. doi: 10.1055/a-1332-6902. Epub 2021 Mar 2. PMID: 33291158. 4. Onimaru M, Inoue H, Bechara R, Tanabe M, Abad MRA, Ueno A, Shimamura Y, Sumi K, Ikeda H, Ito H. Clinical outcomes of per-oral endoscopic tumor resection for submucosal tumors in the esophagus and gastric cardia. Dig Endosc. 2020 Mar;32(3):328-336. doi: 10.1111/den.13471. Epub 2019 Jul 22. PMID: 31234231. 5. Peng W, Tan S, Huang S, Ren Y, Li H, Peng Y, Fu X, Tang X. Efficacy and safety of submucosal tunneling endoscopic resection for upper gastrointestinal submucosal tumors with more than 1-year' follow-up: a systematic review and meta-analysis. Scand J Gastroenterol. 2019 Apr;54(4):397-406. doi: 10.1080/00365521.2019.1591500. Epub 2019 Mar 29. PMID: 30925071. 6. Song S, Wang X, Zhang S, Li Y, Zhang X, Chu X. Efficacy and complications of submucosal tunneling endoscopic resection for upper gastrointestinal submucosal tumors and exploration for influencing factors. Z Gastroenterol. 2018 Apr;56(4):365-373. English. doi: 10.1055/s-0043-123765. Epub 2018 Jan 18. PMID: 29346827. 7. Cao B, Lu J, Tan Y, Liu D. Efficacy and safety of submucosal tunneling endoscopic resection for gastric submucosal tumors: a systematic review and meta-analysis. Rev Esp Enferm Dig. 2021 Jan;113(1):52-59. doi: 10.17235/reed.2020.6989/2020. PMID: 33222480. 8. Liu F, Zhang S, Ren W, Yang T, Lv Y, Ling T, Zou X, Wang L. The fourth space surgery: endoscopic subserosal dissection for upper gastrointestinal subepithelial tumors originating from the muscularis propria layer. Surg Endosc. 2018 May;32(5):2575-2582. doi: 10.1007/s00464-017-5985-z. Epub 2017 Dec 20. PMID: 29264757. 9. Kadkhodayan K, Irani S. Endoscopic truncal vagotomy. Exploring the fourth space. A technical feasibility study in a porcine model. VideoGIE. 2025 Mar 4;10(7):340-344. doi: 10.1016/j.vgie.2025.02.012. PMID: 40642399; PMCID: PMC12237756. 10. Jiang T, Yang Y, Luo W. Application of the fourth space in peroral endoscopic myotomy (POEM) surgery for achalasia. Rev Esp Enferm Dig. 2025 Jun 27. doi: 10.17235/reed.2025.11331/2025. Epub ahead of print. PMID: 40575899. "  [Collapse]
Restrepo-Rodas G, Rodriguez J. Mastering the third space: Innovations in intramural endoscopic surgery for gastrointestinal disorders. World J Gastrointest Endosc 2025; 17(12): 111206
4
"This article addresses an important and timely topic: differentiation-based strategies for colorectal cancer (CRC) therapy using ..."  [Read more]
"This article addresses an important and timely topic: differentiation-based strategies for colorectal cancer (CRC) therapy using natural products. The authors present a comprehensive in vitro study suggesting that Ferula assafoetida (FA) induces differentiation and apoptosis in Caco-2 colon cancer cells, potentially via activation of the JNK/MAPK pathway. As a reader, the work is interesting, methodologically broad, and conceptually aligned with current interests in natural compound–based cancer therapeutics, although certain conceptual and interpretative gaps limit its translational impact. As a reader, I would regard this article as a useful exploratory study that justifies further mechanistic, protein-level, and in vivo investigations, rather than a conclusive demonstration of FA as a differentiation therapy for CRC. "  [Collapse]
Abdelsalam HM, Abdelghany AM, Ahmed WA, Diab AA, Abdellateif MS. Ferula assafoetida induced colon cancer cells differentiation through JNK/MAPK signalling pathway activation. World J Exp Med 2025; 15(4): 110757
5
"his retrospective study by Cooper et al. provides a valuable comparison of endoscopic band ligation (EBL) and endoscopic thermal ..."  [Read more]
"his retrospective study by Cooper et al. provides a valuable comparison of endoscopic band ligation (EBL) and endoscopic thermal therapy (ETT) as initial treatments for nodular gastric antral vascular ectasia (GAVE), a rare and challenging subtype. The analysis of 37 patients demonstrates that EBL outperforms ETT, with significantly higher clinical remission rates (90% vs. 69%, P=0.041), shorter treatment intervals (172 vs. 928 days, P=0.013), and fewer required endoscopic sessions (1.95 vs. 5.56, P=0.009), supported by improved hemoglobin levels and reduced transfusions. The findings robustly advocate for EBL as a first-line approach due to its efficiency and lower treatment burden. However, limitations include the small sample size, single-center design, and retrospective nature, which may affect generalizability. Despite this, the study fills a critical gap in nodular GAVE management and underscores the need for prospective multicenter trials to validate EBL's superiority and optimize clinical protocols. "  [Collapse]
Cooper JA, Statham E, Holyfield A, Shoreibah MG, Peter S. Initial treatment approaches for nodular gastric antral vascular ectasia: A comparison of endoscopic band ligation and thermal therapies. World J Gastrointest Endosc 2025; 17(12): 111872
6
"The minireview by El Dada et al. offers a timely synthesis of endoscopic ultrasound (EUS)-guided coil embolization for gastric varices ..."  [Read more]
"The minireview by El Dada et al. offers a timely synthesis of endoscopic ultrasound (EUS)-guided coil embolization for gastric varices (GVs), highlighting its potential as a safer, precise alternative to traditional therapies like cyanoacrylate injection. Strengths include systematic comparisons with meta-analytic data (e.g., 96.7% obliteration rate for EUS-coil/cyanoacrylate vs. 70.6% for cyanoacrylate alone), practical technical details (coil selection, Doppler confirmation), real-world case illustrations, and cost-effectiveness analysis (1,831vs.11,000 hospitalization). However, limitations persist: reliance on retrospective/single-center data, absence of randomized controlled trials (RCTs) against TIPS/BRTO, and lack of long-term (>5 years) rebleeding/complication data (e.g., coil migration). The authors appropriately call for multicenter RCTs to standardize protocols, explore material combinations, and integrate predictive biomarkers. Despite gaps, the review compellingly argues for EUS-coil’s inclusion in GV guidelines, serving as a valuable reference for advancing therapeutic endoscopy with balanced analysis of efficacy, safety, and accessibility. "  [Collapse]
El Dada A, El Khoury M, Stephan P, Nehme F. Endoscopic ultrasound-guided coil embolization for gastric varices: A promising alternative to traditional therapies. World J Gastrointest Endosc 2025; 17(12): 110168
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"Name of Journal: World Journal of Gastroenterology Manuscript Type: LETTER TO THE EDITOR Dialister-Associated Succinate Dysregulation ..."  [Read more]
"Name of Journal: World Journal of Gastroenterology Manuscript Type: LETTER TO THE EDITOR Dialister-Associated Succinate Dysregulation in Crohn’s Disease: Clinical and Therapeutic Implications 1Fotios S. Fousekis, 1Konstantinos H. Katsanos, 2Konstantinos Vlachos, 2Georgios D. Lianos 1Department of Gastroenterology, University Hospital of Ioannina, University of Ioannina Ioannina, Greece 2Department of Surgery, University Hospital of Ioannina, University of Ioannina, Greece Corresponding author: Fotios S. Fousekis, MD, PhD, Department of Gastroenterology, University Hospital of Ioannina, University of Ioannina Ioannina, Greece, email: fotisfous@gmail.com Abstract Growing evidence suggests that altered gut microbiota–derived succinate metabolism plays an important role in Crohn’s disease activity and postoperative recurrence. Particular emphasis is placed on Dialister, a gut bacterial genus that consumes succinate inefficiently, potentially leading to its accumulation and increased intestinal inflammation. Elevated succinate may impair immune regulation and enhance inflammatory signaling through SUCNR1 activation and hypoxia-inducible factor-1α stabilization. Recent findings identifying specific Dialister strains associated with postoperative recurrence provide new insight into disease monitoring and risk stratification. Although the study offers an integrative view linking microbial composition, metabolism, and inflammation, further validation using direct metabolomic and shotgun metagenomic approaches is needed. Overall, succinate appears to be a promising biomarker and therapeutic target, supporting future microbiota- and metabolism-based strategies for the management of inflammatory bowel disease. Key words: Crohn’s disease; Inflammatory bowel disease; Gut microbiota; Succinate; Dialister; Postoperative recurrence Core tip Accumulation of the microbial metabolite succinate is increasingly recognized as a key driver of inflammation in Crohn’s disease. Recent evidence links Dialister enrichment to impaired succinate clearance, disease activity, and postoperative recurrence, highlighting succinate as a promising biomarker and therapeutic target in inflammatory bowel disease. To the editor Dialister, an anaerobic Gram-negative genus of the human gut microbiome, has gained clinical interest due to its role in succinate metabolism. While capable of utilizing succinate as a substrate for propionate production, Dialister exhibits relatively slow consumption rates compared with efficient succinate consumers such as Phascolarctobacterium. This inefficiency may result in elevated luminal succinate levels, particularly in the context of inflammatory bowel disease (IBD) (1). Succinate accumulation may disrupt regulatory T cell (Treg) function by promoting FOXP3 degradation, thereby reducing immune tolerance and further amplifying inflammation (2). Furthermore, elevated succinate stabilizes hypoxia-inducible factor-1α (HIF-1α) by inhibiting prolyl hydroxylase activity, which prevents HIF-1α degradation and leads to enhanced inflammatory gene expression and perpetuation of tissue injury, particularly in IBD (3). We read with great interest the recently published article by Boronat-Toscano and colleagues on Dialister-driven succinate accumulation and its association with disease activity and postoperative recurrence in Crohn’s disease (4). This study offers valuable insights into a rapidly growing field of research that links gut microbiota, host metabolism, and inflammation. It positions succinate not just as a metabolic by-product but also as a functional biomarker and potential therapeutic target. One of the major strengths of this work is its integrative, multi-level approach, which combines clinical and biochemical measures of disease activity, such as the Harvey–Bradshaw Index, C-reactive protein, and fecal calprotectin, with gut microbiome profiling using 16S rRNA sequencing and host molecular markers related to succinate signaling, specifically the expression of the succinate receptor SUCNR1 (4). Notably, this study highlights specific Dialister operational taxonomic units (OTUs) in the intestinal mucosa that correlate with the risk and severity of postoperative recurrence. This goes beyond existing knowledge by identifying strain-level microbial signatures with potential predictive value, suggesting that variability within Dialister is vital for patient stratification and disease progression after surgery. The authors also propose a mechanism for succinate accumulation in Crohn's disease, involving the downregulation of NADH dehydrogenase and the upregulation of fumarate reductase and succinate transporters. This metabolic shift enhances succinate production and export by the gut microbiota (4). Despite these strengths, we would like to highlight several issues that merit further discussion. The functional analysis of the gut microbiome is based on predictive approaches (PICRUSt2) rather than on direct measurements of metabolic fluxes or shotgun metagenomic sequencing. Validation of these predictions is essential for robust conclusions. Targeted metabolomic analyses, using mass spectrometry or nuclear magnetic resonance, allow for direct quantification of metabolites as succinate and can confirm the functional activity of predicted pathways (5). In addition shotgun metagenomic sequencing may provide a more comprehensive and direct assessment of the genetic potential for metabolic pathways, including those involved in succinate production and consumption, by sequencing all microbial DNA present in a sample (6). These findings also open important avenues for future research and therapeutic development in inflammatory bowel disease. Given the central role of succinate in promoting intestinal inflammation through SUCNR1 activation and HIF-1α stabilization, strategies aimed at reducing succinate accumulation or blocking its downstream signaling pathways warrant further investigation. Microbiota-targeted interventions, including dietary fiber enrichment, prebiotics, and probiotics designed to enhance the abundance of efficient succinate-consuming bacteria such as Phascolarctobacterium, represent a particularly promising approach, as preclinical studies have demonstrated their ability to lower succinate levels, attenuate inflammatory signaling, and restore epithelial barrier integrity (7). Avoiding supplementation of the diet with refined inulin may be considered, as evidence from mouse models suggests that it can induce abnormal succinate accumulation in the intestinal lumen, thereby contributing to colonic inflammation (8). In parallel, pharmacological inhibition of SUCNR1 using small-molecule antagonists, as well as interventions targeting HIF-1α stabilization, may offer complementary strategies to suppress succinate-driven inflammation (9, 10). Huo et al. demonstrated that the SUCNR1 inhibitor NF-56-EJ40 may suppress glycolysis in intestinal epithelial cells and attenuates Th17-mediated inflammation in a dextran sodium sulfate–induced mouse model of ulcerative colitis. Treatment reduced pro-inflammatory cytokine production, improved epithelial barrier integrity, and alleviated colonic injury, supporting SUCNR1 antagonism as a therapeutic strategy targeting both metabolic and immune pathways (7). Consistently, genetic deletion of SUCNR1 in mice protected against both acute colitis and intestinal fibrosis, while in human fibroblasts derived from Crohn’s disease patients, succinate increased SUCNR1 expression and promoted inflammatory and fibrotic markers that were effectively reversed by SUCNR1 blockade (11). While these approaches are supported by growing mechanistic and translational evidence, well-designed clinical trials will be essential to determine their efficacy and safety in patients with IBD. Conclusion The study conducted by Boronat-Toscano et al. enhances the understanding of how microbiota-driven metabolic dysregulation relates to Crohn’s disease by identifing succinate and Dialister-associated microbial signatures associated as important factors that influence disease activity and the likelihood of postoperative recurrence. These findings support the use of succinate-related biomarkers in future risk assessment and postoperative monitoring strategies. Additionally, they provide a strong biological basis for therapeutic interventions that target succinate metabolism or SUCNR1-mediated signaling. Overall, this study marks a crucial step towards developing metabolically informed, microbiome-based precision medicine for IBD. Author contributions: Fousekis FS wrote the original draft; Lianos GD contributed to conceptualization, writing, reviewing and editing; Katsanos KH and Vlachos K participated in drafting the manuscript; and all authors have read and approved the final version of the manuscript. References 1. Anthamatten L, von Bieberstein PR, Menzi C, Zund JN, Lacroix C, de Wouters T, Leventhal GE. Stratification of human gut microbiomes by succinotype is associated with inflammatory bowel disease status. Microbiome. 2024;12(1):186. PMID: 39350289 PMCID: PMC11441152 DOI: 10.1186/s40168-024-01897-8 2. Wang H, Hu D, Cheng Y, Gao Q, Liu K, Mani NL, Tang AY, Iyer R, Gao B, Zhou Q, Yu Q, Weinberg SE, Zhang X, Cong Y, Dulai PS, Zhang Y, Liu Z, Fang D. Succinate drives gut inflammation by promoting FOXP3 degradation through a molecular switch. Nat Immunol. 2025;26(6):866-80. PMID: 40457062 PMCID: PMC12399925 DOI: 10.1038/s41590-025-02166-y 3. Tannahill GM, Curtis AM, Adamik J, Palsson-McDermott EM, McGettrick AF, Goel G, Frezza C, Bernard NJ, Kelly B, Foley NH, Zheng L, Gardet A, Tong Z, Jany SS, Corr SC, Haneklaus M, Caffrey BE, Pierce K, Walmsley S, Beasley FC, Cummins E, Nizet V, Whyte M, Taylor CT, Lin H, Masters SL, Gottlieb E, Kelly VP, Clish C, Auron PE, Xavier RJ, O'Neill LAJ. Succinate is an inflammatory signal that induces IL-1beta through HIF-1alpha. Nature. 2013;496(7444):238-42. PMID: 23535595 PMCID: PMC4031686 DOI: 10.1038/nature11986 4. Boronat-Toscano A, Queipo-Ortuño MI, Monfort-Ferré D, Suau R, Vañó-Segarra I, Valldosera G, Cepero C, Astiarraga B, Clua-Ferré L, Plaza-Andrade I, Aranega-Martín L, Cabrinety L, Abadia de Barbarà C, Castellano-Castillo D, Moliné A, Caro A, Domènech E, Sánchez-Herrero JF, Benaiges-Fernandez R, Fernández-Veledo S, Vendrell J, Ginés I, Sumoy L, Manyé J, Menacho M, Serena C. Dialister-driven succinate accumulation is associated with disease activity and postoperative recurrence in Crohn's disease. World J Gastroenterol. 2025;31(45):112618. PMID: 41378335 PMCID: PMC12687013 DOI: 10.3748/wjg.v31.i45.112618 5. Han S, Van Treuren W, Fischer CR, Merrill BD, DeFelice BC, Sanchez JM, Higginbottom SK, Guthrie L, Fall LA, Dodd D, Fischbach MA, Sonnenburg JL. A metabolomics pipeline for the mechanistic interrogation of the gut microbiome. Nature. 2021;595(7867):415-20. PMID: 34262212 PMCID: PMC8939302 DOI: 10.1038/s41586-021-03707-9 6. Mitra S, Forster-Fromme K, Damms-Machado A, Scheurenbrand T, Biskup S, Huson DH, Bischoff SC. Analysis of the intestinal microbiota using SOLiD 16S rRNA gene sequencing and SOLiD shotgun sequencing. BMC Genomics. 2013;14 Suppl 5(Suppl 5):S16. PMID: 24564472 PMCID: PMC3852202 DOI: 10.1186/1471-2164-14-S5-S16 7. Huo L, Chen Q, Jia S, Zhang Y, Wang L, Li X, Li Z, Sun B, Shan J, Lin J, Yang L, Sui H. Gut microbiome promotes succinate-induced ulcerative colitis by enhancing glycolysis through SUCNR1/NF-kappaB signaling pathway. Am J Physiol Cell Physiol. 2025;329(2):C440-C54. PMID: 40549551 DOI: 10.1152/ajpcell.00411.2025 8. Tian S, Paudel D, Hao F, Neupane R, Castro R, Patterson AD, Tiwari AK, Prabhu KS, Singh V. Refined fiber inulin promotes inflammation-associated colon tumorigenesis by modulating microbial succinate production. Cancer Rep (Hoboken). 2023;6(11):e1863. PMID: 37489647 PMCID: PMC10644334 DOI: 10.1002/cnr2.1863 9. Haffke M, Fehlmann D, Rummel G, Boivineau J, Duckely M, Gommermann N, Cotesta S, Sirockin F, Freuler F, Littlewood-Evans A, Kaupmann K, Jaakola VP. Structural basis of species-selective antagonist binding to the succinate receptor. Nature. 2019;574(7779):581-5. PMID: 31645725 DOI: 10.1038/s41586-019-1663-8 10. Kim YI, Yi EJ, Kim YD, Lee AR, Chung J, Ha HC, Cho JM, Kim SR, Ko HJ, Cheon JH, Hong YR, Chang SY. Local Stabilization of Hypoxia-Inducible Factor-1alpha Controls Intestinal Inflammation via Enhanced Gut Barrier Function and Immune Regulation. Front Immunol. 2020;11:609689. PMID: 33519819 PMCID: PMC7840603 DOI: 10.3389/fimmu.2020.609689 11. Macias-Ceja DC, Ortiz-Masia D, Salvador P, Gisbert-Ferrandiz L, Hernandez C, Hausmann M, Rogler G, Esplugues JV, Hinojosa J, Alós R; Navarro F, Cosin-Roger J, Calatayud S, Barrachina MD. Succinate receptor mediates intestinal inflammation and fibrosis. Mucosal Immunol. 2019;12(1):178-87. PMID: 30279517 DOI: 10.1038/s41385-018-0087-3 "  [Collapse]
Boronat-Toscano A, Queipo-Ortuño MI, Monfort-Ferré D, Suau R, Vañó-Segarra I, Valldosera G, Cepero C, Astiarraga B, Clua-Ferré L, Plaza-Andrade I, Aranega-Martín L, Cabrinety L, Abadia de Barbarà C, Castellano-Castillo D, Moliné A, Caro A, Domènech E, Sánchez-Herrero JF, Benaiges-Fernandez R, Fernández-Veledo S, Vendrell J, Ginés I, Sumoy L, Manyé J, Menacho M, Serena C. Dialister-driven succinate accumulation is associated with disease activity and postoperative recurrence in Crohn’s disease. World J Gastroenterol 2025; 31(45): 112618
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"This minireview systematically synthesizes the intricate interplay between depression and gastric cancer (GC), incorporating ..."  [Read more]
"This minireview systematically synthesizes the intricate interplay between depression and gastric cancer (GC), incorporating neuroendocrine, immunological, and psychosocial mechanisms. The authors effectively underscore the bidirectional causality supported by 52 referenced studies, in alignment with the biopsychosocial model. Nonetheless, there are opportunities to enhance methodological rigor and visual communication. Although Figure 1 delineates key components of the bidirectional relationship, its informational density is suboptimal. The figure lacks a hierarchical structuring of pathways (e.g., neuroendocrine versus immune mechanisms) and does not quantify effect sizes (e.g., hazard ratios from cited meta-analyses). It is recommended to incorporate a summary table for comparison. "  [Collapse]
Chen Z, Gong TJ, Zhao L. Bidirectional relationship between depression and the risk and prognosis of gastric cancer. World J Gastrointest Oncol 2025; 17(12): 113272
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"I want to congratulate the authors, Zhang et al, for conducting a study and identifying the predictors of refractory GERD. They have ..."  [Read more]
"I want to congratulate the authors, Zhang et al, for conducting a study and identifying the predictors of refractory GERD. They have identified the disease duration and anxiety as significant risk factors and at least 90 minutes of moderate-intensity physical activity per week as a protective factor for refractory GERD. One of the important findings in this study is the association of significant Overlap DGBI symptoms (such as dyspepsia, constipation, and diarrhoea) in at least 50% of GERD patients. Since most patients had a duration of illness of more than 4 years, complications of GERD and their comparison between the groups were not noted in this study (a limitation). Although hydrogen impedance is used for diagnosis, the comparison of impedance parameters is not provided. H pylori infection is a protective factor for GERD/Barrett's, which is also a limitation. This study has provided a meaningful conclusion regarding the association between long-term symptoms and refractoriness. "  [Collapse]
Zhang N, Wang Y, Fang SS, Han M, Zheng QW, Zhu YY, Zhang MY, Li JJ, Cui LX, Tian JL, Deng YH, Zhu SL, Ni HM, Zhou L, Zuo GL, Huang TS, Liao Q, Li XQ, Shang YY, Wang YJ, Tian Y, Ge LY, Han HQ, Hu WM, Jiang Y, Li YJ, Mao X, Yang LH, Yao JM, Zheng X, Wang HW, Fang SQ. Clinical characteristics and risk factors of refractory gastroesophageal reflux disease: A multicenter cross-sectional study. World J Gastroenterol 2025; 31(45): 113060
10
"The present Letter provides a concise academic response to the article identified by Reader’s code 05354032. The comments focus on ..."  [Read more]
"The present Letter provides a concise academic response to the article identified by Reader’s code 05354032. The comments focus on several important aspects of the study, including its methodological design, data interpretation, and clinical applicability. The aim is to offer constructive perspectives that may help clarify key issues and support future improvements in related research. "  [Collapse]
Ardila CM, Ángel-Estrada S, González-Arroyave D. Robot-assisted vs conventional lumbar interbody fusion: A systematic review and meta-analysis of perioperative, radiographic, and clinical outcomes. World J Orthop 2025; 16(11): 110276
11
"The study title "Comparison of the efficacy of laparoscopic hepatectomy and radiofrequency ablation for small hepatocellular ..."  [Read more]
"The study title "Comparison of the efficacy of laparoscopic hepatectomy and radiofrequency ablation for small hepatocellular carcinoma: A retrospective study" by Lei et al. aims to compare the long-term survival and perioperative outcomes of Laparoscopic hepatectomy (LH) and radiofrequency ablation (RFA) for small hepatocellular carcinoma (HCC). This retrospective study included 254 patients with small HCC who were collected from Hospital of Chongqing Medical University between December 2022 and March 2025. The results showed that LH was associated with longer operative time, greater blood loss, prolonged recovery, higher costs, and increased complication rates. Consequently, LH, though associated with increased perioperative morbidity, provides superior long-term survival outcomes compared with RFA in patients with small HCC. This study had many limitations such as potential for selection bias and confounding factors that were not controlled for is inherent. The decision to undergo either LH or RFA was made based on clinical judgment and patient-specific factors, which could introduce bias. The sample size was still be insufficient to detect subtle differences in outcomes between the two modalities, especially for subgroups with specific tumor characteristics or comorbidities. Moreover, LH and RFA techniques have evolved over time, and variations in operator experience and institutional protocols could influence outcomes. "  [Collapse]
Lei ZL, Tan ZL, Luo YH, Yang M, Wang JL, Qin Z, Liu YY. Comparison of the efficacy of laparoscopic hepatectomy and radiofrequency ablation for small hepatocellular carcinoma: A retrospective study. World J Gastroenterol 2025; 31(45): 111540
12
"We are delighted to read the high-quality review by Zheng et al[1], published in the World Journal of Gastroenterology, which offers ..."  [Read more]
"We are delighted to read the high-quality review by Zheng et al[1], published in the World Journal of Gastroenterology, which offers insightful perspectives on the neuroimmune mechanisms contributing to the pathogenesis of inflammatory bowel disease (IBD). The intricate interplay between the autonomic nervous system (ANS) and the immune response, particularly involving vagus nerve stimulation (VNS) and its effects on macrophages, provides a promising avenue for future therapeutic interventions in IBD. The review underscores the emerging concept of neuroimmune interactions, particularly the cholinergic anti-inflammatory pathway (CAIP), which regulates inflammation through the vagus nerve and its interaction with intestinal macrophages. This is an exciting area of research, especially in the context of IBD, where inflammation is at the heart of the disease's pathology. Macrophages, as highlighted in the review, play a crucial role in maintaining intestinal homeostasis, but when overactivated, they contribute to the excessive production of proinflammatory cytokines, exacerbating the condition. This review draws attention to how the cholinergic system can modulate macrophage activity, reducing the inflammatory burden through the activation of the α7 nicotinic acetylcholine receptor (α7nAChR). The role of VNS as an approach to activate the cholinergic pathway and regulate inflammation in IBD is a breakthrough concept. Studies showing the beneficial effects of VNS in reducing inflammation and enhancing immune tolerance are promising, offering a potential alternative to conventional treatments, especially in patients with refractory IBD. Furthermore, the use of VNS to modulate the autonomic nervous system offers a unique therapeutic strategy for restoring balance between sympathetic and parasympathetic tones in patients, whose autonomic dysfunction may contribute to disease exacerbation. While the current data on VNS in IBD are promising, the review rightly calls for further research to better establish the clinical applicability of VNS, especially through non-invasive techniques such as transauricular and transcervical VNS. These methods, as highlighted, may offer a safer and more accessible alternative to invasive VNS, which has shown positive effects in treating other inflammatory conditions. The ongoing exploration of VNS in clinical trials, coupled with advancements in understanding the mechanisms of cholinergic signaling in immune cells, opens new avenues for therapeutic interventions in chronic inflammatory diseases. However, as the review mentions, there are still challenges that need to be addressed. The precise mechanisms through which VNS modulates immune responses, particularly in macrophages, are still under investigation. Additionally, while VNS has shown potential in preclinical models, there is a need for larger, well-designed clinical studies to confirm the safety, efficacy, and long-term benefits of VNS in IBD patients. The heterogeneity of IBD, along with differences in patient responses to treatment, further complicates the development of standardized protocols for VNS treatment. In conclusion, the review provides an excellent overview of the current state of research on neuroimmune interactions in IBD, with a special focus on the potential of VNS as a novel therapeutic strategy. The integration of neuroimmune regulation, particularly through the cholinergic pathway, into the treatment of IBD represents an innovative approach that could offer significant improvements in patient outcomes. As we move forward, I hope that the continued research in this field will provide more concrete evidence to support the use of VNS in clinical practice, potentially offering a transformative treatment for IBD patients who have not responded to traditional therapies. LIMITATIONS OF THE REVIEW While the review provides a comprehensive overview of the potential therapeutic role of vagus nerve stimulation (VNS) in inflammatory bowel disease (IBD), there are some limitations that should be addressed in future research. First, while the article highlights the promising effects of VNS, particularly through the cholinergic anti-inflammatory pathway (CAIP), there is a lack of in-depth discussion regarding the specific cellular mechanisms involved. The exact signaling pathways through which VNS modulates macrophage activity and alters immune responses remain unclear, and more detailed mechanistic studies are needed to provide a clearer understanding. Additionally, the review does not fully address the challenges associated with the translation of VNS into clinical practice. For instance, the variability in patient response to VNS, the optimal stimulation parameters (e.g., frequency, duration, and intensity), and the potential side effects of VNS, particularly in IBD patients with coexisting conditions, are aspects that require more attention. Lastly, the review focuses primarily on the autonomic nervous system's role in IBD, but it overlooks other possible neuroimmune interactions that could also influence disease progression. A broader exploration of how other neural pathways or neuropeptides contribute to IBD would provide a more comprehensive view of the neuroimmune mechanisms at play. CONCLUSION The review provides an insightful exploration of the neuroimmune mechanisms involved in inflammatory bowel disease (IBD), particularly focusing on the role of intestinal macrophages and the cholinergic anti-inflammatory pathway. Vagus nerve stimulation (VNS) represents a promising non-invasive therapeutic approach for modulating the immune system and controlling inflammation in IBD. However, further research is needed to fully understand the mechanisms behind VNS and to establish its efficacy in clinical settings for treating chronic inflammatory diseases such as IBD. With the development of non-invasive VNS technologies, future therapies may offer safer and more effective treatments for patients suffering from IBD. "  [Collapse]
Zheng L, Duan SL. Neuroimmune interactions in inflammatory bowel disease: Role of intestinal macrophages and the cholinergic pathway. World J Gastroenterol 2025; 31(44): 109440
13
"This editorial provides a comprehensive and insightful overview of self-expandable metal stents (SEMS) in acute colonic obstruction, ..."  [Read more]
"This editorial provides a comprehensive and insightful overview of self-expandable metal stents (SEMS) in acute colonic obstruction, standing out for its clinical relevance and systematic organization. The authors adeptly synthesize cutting-edge techniques (e.g., fluoroscopy-free stenting, two-person colonoscopy) and critical considerations like stent design selection, backed by high-quality recent evidence, which offers valuable guidance for clinical practice. The discussion of complications and mitigation strategies is pragmatic, while the exploration of future directions (e.g., zero-border stents, multidisciplinary collaboration) reflects a forward-thinking perspective. The academic expression is precise and fluent, with consistent use of professional terminology and clear logical progression. A minor suggestion is to include brief comparative data on cost-effectiveness among different stenting techniques or stent types, which would further assist healthcare institutions in decision-making. Overall, this is a high-quality, clinically impactful piece that serves as an excellent reference for gastroenterologists and surgeons specializing in colorectal disorders. "  [Collapse]
Sun HY, Li ZC, Wang HL. Current mechanisms and techniques for placement of self-expandable metal stents in acute colonic obstruction. World J Gastrointest Surg 2025; 17(11): 110512
14
"The editorial authored by Watanabe presents a timely and clinically pertinent overview of lisocabtagene maraleucel (liso-cel) CAR-T ..."  [Read more]
"The editorial authored by Watanabe presents a timely and clinically pertinent overview of lisocabtagene maraleucel (liso-cel) CAR-T therapy, specifically addressing nodal and gastrointestinal follicular lymphoma (GI-FL). The author skillfully amalgamates essential findings from the TRANSCEND FL trial, emphasizing the extraordinary 97% overall response rate and a 94% complete response rate, alongside a notably reduced toxicity profile where grade ≥3 cytokine release syndrome (CRS) was absent, and grade ≥3 neurotoxicity was observed in merely 3% of patients. This concentrated analysis on the unique advantages of liso-cel—particularly its defined CD4+/CD8+ composition and the feasibility of outpatient treatment—addresses a significant void in the existing literature, especially in light of the historical exclusion of GI-FL from crucial CAR-T trials. The comparative framework juxtaposing lisocabtagene maraleucel with axicabtagene ciloleucel and tisagenlecleucel provides invaluable insights for clinical decision-making. Nevertheless, the editorial's otherwise robust examination fails to explore subtleties regarding the durability of response in high-risk subpopulations. Although the reported 12-month progression-free survival rate exceeding 85% is promising, emerging data indicate that follicular lymphoma patients with specific genomic alterations (e.g., TP53 mutations or 1p36 deletions) display varied responsiveness to CAR-T therapy. This omission is particularly salient for GI-FL, where the biological characteristics of the disease may diverge from those of nodal FL due to influences from the microenvironment. Furthermore, the editorial rightly recognizes cost as a barrier but insufficiently emphasizes how the manufacturing logistics of Liso-Cel disproportionately hinder accessibility in advanced GI-FL cases. Unlike nodal FL, where treatment delays may be manageable, GI-FL frequently presents urgent complications necessitating swift intervention. The three-week manufacturing timeline for liso-cel—despite improvements over previous platforms—remains a challenge for these patients, a difficulty exacerbated by the absence of validated bridging strategies tailored to gastrointestinal involvement. Looking ahead, the integration of endoscopic and molecular staging systems (e.g., Paris classification) with CAR-T therapy response biomarkers emerges as a critical research priority. Real-world studies should specifically investigate GI-FL cohorts to ascertain whether mucosal disease localization influences CAR-T trafficking or persistence. Additionally, the formulation of risk-adapted conditioning regimens could optimize the therapeutic index in patients with gastrointestinal involvement, where organ-specific toxicities remain inadequately characterized. Watanabe's appeal for multicenter collaboration should explicitly encompass these mechanistic and health-services research inquiries to propel personalized CAR-T applications across follicular lymphoma subtypes. "  [Collapse]
Watanabe T. Emerging role of lisocabtagene maraleucel chimeric antigen receptor-T cell in nodal and gastrointestinal follicular lymphoma. World J Gastroenterol 2025; 31(45): 112336
15
"This review elevates our understanding of acetaminophen (APAP)-induced acute liver injury from a “single toxic metabolite acting on ..."  [Read more]
"This review elevates our understanding of acetaminophen (APAP)-induced acute liver injury from a “single toxic metabolite acting on hepatocytes” model to a dynamic network involving multiple hepatic cell populations. Second, it clearly maps out current and potential therapeutic targets, essentially providing a “cell-type–oriented treatment roadmap” for future translational work. The discussion of CYP2E1/CYP3A4, species differences, and risk factors (such as alcohol use, malnutrition, underlying liver disease, and concomitant enzyme-inducing drugs) helps clinicians better identify high-risk populations and appreciate the limitations of extrapolating from animal models, thereby supporting more individualized risk assessment and dosing. In the treatment section, the authors extend beyond the classical “N-acetylcysteine golden window” and cover emerging strategies such as inhibition of NAPQI formation (e.g. fomepizole), mitochondria-targeted antioxidants (Mito-Tempo, MitoQ), modulation of ferroptosis/ferritinophagy, NLRP3–STING inflammasome pathways, as well as cell-based and hepatocyte transplantation therapies. This allows clinical readers to quickly grasp potential combination or alternative approaches that are entering or approaching clinical trials, while signaling to basic scientists multiple promising cellular pathways and targets for deeper exploration. Overall, the article reads as an up-to-date progress review on the multicellular mechanisms and therapeutic targets of APAP-induced acute liver injury, offering both mechanistic clarity and topic inspiration for those working on drug-induced liver injury, emergency/critical care, and liver transplantation—while also realistically emphasizing that most of the evidence remains at the experimental or early translational stage and is not yet ready to change clinical guidelines. "  [Collapse]
Yang D, Kim B, Kim JW. Mechanistic insights into hepatic cell type-specific contributions to acetaminophen-induced acute liver injury. World J Gastroenterol 2025; 31(45): 112720
16
"this review provides a clear and systematic overview of the interactions among intestinal macrophages, the enteric nervous system, ..."  [Read more]
"this review provides a clear and systematic overview of the interactions among intestinal macrophages, the enteric nervous system, and the cholinergic anti-inflammatory pathway in inflammatory bowel disease (IBD). By closely linking basic mechanistic insights with the potential clinical application of vagus nerve stimulation (VNS)—especially low-frequency, non-invasive VNS—the paper offers a fresh “neuroregulation–immune modulation” angle on IBD treatment, which is currently dominated by immunosuppressants and biologics. In terms of clinical practicality, the authors emphasize the promise of non-invasive VNS as a safer and more tolerable approach, while frankly acknowledging that current evidence still largely comes from animal models and a few pilot clinical studies, with a lack of large-scale randomized controlled trials. This “promising yet cautious” tone is valuable for clinical readers. On the one hand, the paper helps gastroenterologists and basic scientists understand why heart rate variability (HRV), emotional status, and autonomic imbalance may be linked to IBD course and relapse; on the other hand, it reminds readers that VNS and α7nAChR-targeted agents are still at the stages of proof-of-concept and early translation. In the short term, their main value lies in inspiring new research designs (for example, clinical trials stratified by HRV, combined with intestinal macrophage phenotype analysis), rather than immediately changing standard treatment pathways. Overall, this work reads like a forward-looking “blueprint” for neuro-immune therapies in IBD and is particularly thought-provoking for readers interested in IBD mechanisms and novel therapeutic strategies. "  [Collapse]
Zheng L, Duan SL. Neuroimmune interactions in inflammatory bowel disease: Role of intestinal macrophages and the cholinergic pathway. World J Gastroenterol 2025; 31(44): 109440
17
"Commentary on "Large Language Models and Large Concept Models in Radiology: Present Challenges, Future Directions, and Critical ..."  [Read more]
"Commentary on "Large Language Models and Large Concept Models in Radiology: Present Challenges, Future Directions, and Critical Perspectives" The transition from LLMs to LCMs, aiming for enhanced semantic reasoning, is fundamentally challenged by the necessity of building these sophisticated models upon historical data streams polluted by human cognitive biases [1]. Diagnostic interpretation errors are often not perceptual misses but interpretive errors driven by faulty reasoning [2,3]. These biases include Anchoring Bias, where a radiologist becomes fixated on an initial impression despite contradictory evidence, often coupled with Confirmation Bias, the inclination to seek information only to affirm that initial theory [2,4,5]. Similarly, Availability Bias, or availability heuristics, predisposes the interpreter to recall recently seen or memorable diagnoses regardless of the actual prevalence [3,4,6]. When AI learns its "concepts" or "relationships" from millions of reports generated under the influence of these specific biases, it may normalize or amplify flawed reasoning patterns, potentially leading to widespread, systemic diagnostic vulnerabilities that mirror rather than correct human limitations [3]. For instance, an AI trained primarily on reports that exhibit Zebra Retreat—the avoidance of accurate but rare diagnoses due to lack of confidence—will systematically underreport uncommon but critical findings, reducing the diagnostic sensitivity for edge cases [2,6]. The core strength of future AI systems must therefore lie not just in conceptual depth but in active debiasing, mitigating the human errors that underpin the training corpus [4,5]. If AI recommendations are opaque, clinicians may fall prey to Blind Obedience or Premature Closure by accepting the machine's initial diagnosis without critical Type 2 analysis [2,6]. To counter this, AI must incorporate the same cognitive forcing strategies used by human interpreters, demanding metacognition ("thinking about thinking") to identify susceptibility to bias [3,4]. Furthermore, AI must specifically address the Hindsight Bias that plagues retrospective quality review [2,6], by ensuring its decision pathways are fully auditable and transparent, allowing for objective assessment of whether an error resulted from inherent data contamination or algorithmic failure. As AI integrates deeper into clinical workflows, its ability to enhance safety hinges on proactively resisting the transfer and propagation of predictable human cognitive limitations [6]. References 1. Merchant SA, Merchant N, Varghese SL, Shaikh MJS. Large language models and large concept models in radiology: Present challenges, future directions, and critical perspectives. World J Radiol. 2025;17(11):114754. [DOI: 10.4329/wjr.v17.i11.114754] 2. Onder O, Yarasir Y, Azizova A, Durhan G, Onur MR, Ariyurek OM. Errors, discrepancies and underlying bias in radiology with case examples: a pictorial review. Insights Imaging. 2021;12:51. [PMID: 33877458. DOI: 10.1186/s13244-021-00986-8] 3. Chen J, Gandomkar Z, Reed WM. Investigating the impact of cognitive biases in radiologists' image interpretation: A scoping review. Eur J Radiol. 2023;166:111013. [PMID: 37541180. DOI: 10.1016/j.ejrad.2023.111013] 4. Busby LP, Courtier JL, Glastonbury CM. Bias in Radiology: The How and Why of Misses and Misinterpretations. Radiographics. 2018;38:236–247. [PMID: 29194009. DOI: 10.1148/rg.2018170107] 5. Gunderman RB. Biases in radiologic reasoning. AJR Am J Roentgenol. 2009;192:561–564. [PMID: 19234247. DOI: 10.2214/AJR.08.1220] 6. Yoon SY, Lee KS, Bezuidenhout AF, Kruskal JB. Spectrum of Cognitive Biases in Diagnostic Radiology. Radiographics. 2024;44:e230059. [PMID: 38843094. DOI: 10.1148/rg.230059] "  [Collapse]
Merchant SA, Merchant N, Varghese SL, Shaikh MJS. Large language models and large concept models in radiology: Present challenges, future directions, and critical perspectives. World J Radiol 2025; 17(11): 114754
18
"The authors present a clinically important case highlighting the coexistence of mixed connective tissue disease (MCTD) and ..."  [Read more]
"The authors present a clinically important case highlighting the coexistence of mixed connective tissue disease (MCTD) and tuberculosis (TB), a scenario that poses substantial diagnostic challenges in TB-endemic regions. The manuscript is well structured and clearly describes the sequence of clinical events, laboratory workup, and therapeutic decisions. The discussion appropriately emphasizes the overlap between autoimmune manifestations and infectious etiologies, particularly when both present with pulmonary involvement. From an academic standpoint, the case is relevant and contributes meaningfully to the limited global literature examining MCTD–TB coexistence. The authors successfully integrate immunological findings with epidemiological considerations, underscoring the need for high clinical suspicion and comprehensive autoimmune evaluation in complex presentations. The reference list is current and well selected, drawing from both rheumatology and infectious disease literature. The language is generally clear and understandable, although a few sections may benefit from stylistic tightening to improve flow, particularly in the discussion where multiple concepts are presented in close succession. Minor grammatical refinements could enhance readability. The inclusion of comprehensive tables and immunological profiles strengthens the diagnostic clarity of the case. For future research and case documentation, the authors may consider: 1. Providing a more detailed longitudinal follow-up, especially regarding TB status, autoimmune markers, and treatment tapering, as long-term outcomes for MCTD-TB coexistence are not well described in the literature. 2. Elaborating on radiologic findings, given the central role of imaging in differentiating pulmonary TB from autoimmune lung involvement. 3. Discussing possible immunopathological links between chronic infections and autoimmune flare, which could enrich the mechanistic understanding of such overlap syndromes. 4. Addressing medication safety monitoring, particularly concerning hepatotoxicity in the context of ATT combined with corticosteroids and hydroxychloroquine. Overall, this is a valuable clinical contribution that highlights key diagnostic considerations in resource-limited, TB-endemic settings. The manuscript is academically sound, clinically relevant, and will be informative for physicians managing complex autoimmune presentations. "  [Collapse]
Sial F, Basit A, Ghafoor N, Sial W, Basil AM. Mixed connective tissue disease and tuberculosis coexistence as a diagnostic dilemma: A case report. World J Clin Cases 2025; 13(33): 109866
19
"The review by Nian et al. offers a thorough and thoughtfully articulated overview of current insights into Osteopontin (OPN)–mediated ..."  [Read more]
"The review by Nian et al. offers a thorough and thoughtfully articulated overview of current insights into Osteopontin (OPN)–mediated PI3K/AKT signaling and its pivotal influence on gastrointestinal cancer progression, metastatic behavior, and therapeutic resistance. The authors skillfully synthesize mechanistic and translational findings, underscoring how OPN-driven activation of the PI3K/AKT pathway promotes epithelial–mesenchymal transition, metabolic adaptation, immune escape, and chemoresistance. Their discussion of OPN splice variants, tumor microenvironment interactions, and biomarker-informed therapeutic strategies provides meaningful guidance for advancing precision oncology. A major strength of the review is its emphasis on the inherent complexity and compensatory nature of OPN–PI3K/AKT signaling, which helps explain the challenges associated with single-agent therapeutic approaches. The recommendation to pursue combination strategies—such as pairing PI3K/AKT inhibitors with immune checkpoint blockade or OPN-targeted antibodies—is timely and supported by accumulating preclinical data. Furthermore, the manuscript’s focus on PIK3CA mutation subsets and OPN expression as potential predictive biomarkers may enable more refined patient stratification in future clinical trials. Despite these promising avenues, clinical translation remains constrained. Current trials evaluating PI3K/AKT inhibitors in gastrointestinal malignancies have yielded limited efficacy and notable toxicity, highlighting the need for more rigorous biomarker-driven study designs. Although the review acknowledges these issues, a deeper appraisal of the reasons underlying clinical shortcomings—and the specific contribution of OPN signaling to these obstacles—would further strengthen its clinical impact. In sum, this review provides a valuable contribution by elucidating the diverse oncogenic roles of OPN and outlining strategic paths toward overcoming therapeutic resistance. Continued research into isoform-specific activity, tumor microenvironmental dynamics, and rational combinatorial regimens will be crucial for realizing the therapeutic potential of targeting the OPN–PI3K/AKT axis in gastrointestinal cancers. "  [Collapse]
Nian H, Bai Y, Wang HY, Yu H, Zhang ZL, Shi RH, Zhang S, Wu YB, Zhou DH, Du QC. Targeting the Osteopontin-regulated PI3K/AKT signaling pathway: A molecular approach to overcome drug resistance and metastasis in gastrointestinal tumors. World J Gastrointest Oncol 2025; 17(11): 109923
20
"This article presents an interesting retrospective study involving a substantial cohort of patients, highlighting the role of total ..."  [Read more]
"This article presents an interesting retrospective study involving a substantial cohort of patients, highlighting the role of total neoadjuvant therapy (TNT), specifically the RAPIDO protocol, compared to conventional long-course chemoradiotherapy (LCCRT) in the management of locally advanced rectal cancer (LARC). The study focuses on early surgical outcomes, a topic of significant clinical relevance. The cornerstone of LARC treatment remains optimal surgical resection via total mesorectal excision (TME). To reduce locoregional failure, preoperative concurrent chemoradiotherapy has long been the standard of care. However, as noted in the article and supported by prior evidence (e.g., Fokas et al.), the efficacy of this approach is primarily confined to local control, while distant metastases continue to be a major cause of treatment failure and compromised survival. The intensification of neoadjuvant therapy through TNT addresses this limitation by achieving early systemic control, significant tumor downstaging, and higher rates of pathological complete response, all without compromising early surgical outcomes compared to LCCRT, as demonstrated in this study. Moreover, the authors report that TNT is associated with a shorter total stoma duration and a lower permanent stoma rate, which are meaningful benefits for patients' quality of life. Recent landmark trials, such as RAPIDO and PRODIGE 23, have provided robust evidence supporting the use of TNT, showing improved pathological complete response, better treatment compliance, and reduced distant metastases compared to LCCRT. This study adds valuable real-world data to the growing body of literature affirming the safety and feasibility of TNT from a surgical perspective. We commend the authors for their contribution and agree that further prospective studies with longer follow-up are warranted to evaluate long-term oncological outcomes. (By Prof Sanaa El Majjaoui and Pr Nabil Ismaili) "  [Collapse]
Jabbar SAA, Choo ALE, Wong NW, Ngu JCY, Teo NZ. Comparing early surgical outcomes between total neoadjuvant therapy and standard long course chemoradiotherapy for rectal cancer. World J Gastrointest Oncol 2025; 17(11): 111250
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