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2025-12-19 | Browse: 21 | Download: 0
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885 items Read more >>
1
"From the initial draft to the final draft, there have been many revisions, involving the differences between traditional Chinese ..."
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"From the initial draft to the final draft, there have been many revisions, involving the differences between traditional Chinese medicine and Western medical concepts, as well as the influence of domestic and foreign differences. We would like to thank the reviewing experts for their attempts to accept the new concepts, which have a very positive impact on strengthening the integration of concepts between China and the international medical field. Thank you very much for the opinions and suggestions provided by the experts during my peer review, and thank you to the journal editors for their help and guidance. In short, this was a very beneficial submission experience. "
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Chen WH, Zhuang C, Guo WJ, Guo WX, He W, Pan Y. Outcomes of the conservative hip preservation treatment in patients with osteonecrosis of the femoral head: With 4-year follow-up. World J Orthop 2025; 16(12): 110291
2
"Again, this was a very positive and professional publishing experience with BPG. The editorial process was smooth, well organized, ..."
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"Again, this was a very positive and professional publishing experience with BPG. The editorial process was smooth, well organized, and efficient from submission to final decision. Communication with the editorial team was clear and timely, and the reviewers’ comments were constructive and helpful. Overall, BPG continues to demonstrate high standards and reliability in academic publishing. "
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Meristoudis G, Savvidis C, Ilias I. Chronotherapeutic optimization of radioactive iodine therapy in differentiated thyroid cancer: The rationale for evening administration. World J Exp Med 2025; 15(4): 110893
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Lin CX, Liu XR, Lin KB. Acute poisoning and psychological trauma: Bridging emergency care to long-term mental health rehabilitation. World J Psychiatry 2025; 15(12): 111516
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"We sincerely thank the peer reviewers for their thoughtful, constructive, and rigorous evaluation of our manuscript. Their insightful ..."
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"We sincerely thank the peer reviewers for their thoughtful, constructive, and rigorous evaluation of our manuscript. Their insightful comments and recommendations significantly strengthened the scientific clarity, methodological rigor, and clinical relevance of the article. We are particularly grateful for the reviewers’ expertise, which helped refine key technical aspects of the procedure and enhance the discussion of its indications, safety, and outcomes. "
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El Dada A, El Khoury M, Stephan P, Nehme F. Endoscopic ultrasound-guided coil embolization for gastric varices: A promising alternative to traditional therapies. World J Gastrointest Endosc 2025; 17(12): 110168
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"We would like to express our sincere gratitude to the editorial team of the World Journal of Experimental Medicine (WJEM) for providing ..."
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"We would like to express our sincere gratitude to the editorial team of the World Journal of Experimental Medicine (WJEM) for providing us with the opportunity to submit our manuscript. The manuscript preparation guidelines were detailed, comprehensive, and easy to follow, which facilitated a smooth and efficient submission process. The online submission system was intuitive and well-organized. The peer-review process was prompt, transparent, and rigorous. The reviewers provided valuable and constructive comments that substantially improved the scientific quality and clarity of our manuscript. Editorial decisions were communicated efficiently at each stage of the review process. Furthermore, the final published version was consistent, accurate, and clear, reflecting the meticulous and expert proofreading and copy-editing procedures. Throughout the publication process, communication with the editorial office was positive and constructive. Overall, we had a very positive experience with WJEM and greatly appreciate the professionalism, efficiency, and commitment to academic integrity demonstrated by the editorial team. We would be pleased to consider submitting our future work to this journal. However, we would like to note that the time taken to publish the accepted manuscript was considerably longer. This posed a challenge, particularly for graduate students, as it led to delays in academic progression and timely reporting for funding requirements. Additionally, the requirement for additional supporting documents appeared to be largely redundant, and completing forms for the same information was somewhat tedious. We kindly request that the journal consider reducing the publication timeline and minimizing the procedural burden associated with the preparation of additional documentation, as the required information is already included in the manuscript itself. "
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Joseph JHM, Babu Deva Irakkam MP, Kandasamy M. Proneurogenic and microglial modulatory properties of botulinum neurotoxin in the hippocampus of aging experimental mice. World J Exp Med 2025; 15(4): 108187
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"This journal was overall great to work with. The peer reviewers were identified quickly and provided throughful and fair feedback. ..."
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"This journal was overall great to work with. The peer reviewers were identified quickly and provided throughful and fair feedback. The journal provided comments and proofs quickly and were easy to contact. The instructions for authors were clearly outlined. I will be sending additional articles here in the future as this was a great experience. "
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DiIorio S, Griffin M. Considering the importance of ankle pathology in total knee arthroplasty recovery. World J Orthop 2025; 16(11): 110279
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"I am really happy with all the publication process, but if I may suggest something, i think the requirement for the english editing ..."
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"I am really happy with all the publication process, but if I may suggest something, i think the requirement for the english editing should be waived when the last author of the manuscript has already shown that he/she has a solid publication track. Thanks for giving the authors de opportunity to evaluate the publication process. "
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Cardín-Pereda A, García-Sánchez D, Álvarez-Iglesias I, Cabello-Sanz J, Pérez-Campo FM. Altered lineage commitment of bone marrow mesenchymal stem cells in idiopathic osteonecrosis of the femoral head. World J Orthop 2025; 16(12): 113320
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"Excellent journal and managing team. Very efficient handling and processing. All in all a very smooth and effortlessly process. ..."
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"Excellent journal and managing team. Very efficient handling and processing. All in all a very smooth and effortlessly process. Hopefully will have many more publications in this reputable and upcoming journal. I hope the journal continues to achieve more success, and the same be reflected in the ever improving journal metrics. Only concern I have is the long publication timeline for this one compared to other BPG journals. "
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Mehta H, Gupta S, Hatwal J, Sohal A, Batta A, Mohan B. Psoriasis and atrial fibrillation: Exploring the intersection. World J Exp Med 2025; 15(4): 107425
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"We sincerely extend our heartfelt gratitude to all the dedicated staff members for their unwavering commitment, meticulous efforts, ..."
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"We sincerely extend our heartfelt gratitude to all the dedicated staff members for their unwavering commitment, meticulous efforts, and invaluable contributions throughout the entire process of curating and publishing this work, which have been instrumental in ensuring its quality and success. We sincerely extend our heartfelt gratitude to all the dedicated staff members for their unwavering commitment, meticulous efforts, and invaluable contributions throughout the entire process of curating and publishing this work, which have been instrumental in ensuring its quality and success. "
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Sun SN, Wang K, Xu Y, Ye F, Xia WN, Wang ZW, Liu F, He ZX, Chen M, Du QH. Saffron and Calculus bovis combination exerts anti-hepatic fibrotic effect in liver fibrosis rats via the mitogen-activated protein kinases pathway. World J Gastroenterol 2025; 31(47): 113496
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"We sincerely appreciate the thorough and constructive feedback provided by the reviewers. Their insightful comments and valuable ..."
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"We sincerely appreciate the thorough and constructive feedback provided by the reviewers. Their insightful comments and valuable suggestions were instrumental in significantly strengthening the manuscript. The revisions have undoubtedly enhanced the clarity of our arguments, the depth of our analysis, and the overall impact of the paper. We are also very grateful for the editorial team's efficient handling of the manuscript and for facilitating this invaluable peer-review process. The journal's high standards have certainly helped us produce a much more polished and robust piece of work. "
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Wang D, Zhang JY, Xie Y, Zhang KN, Jiang WT. Interpretable machine learning model for early complication prediction after split liver transplantation. World J Gastroenterol 2025; 31(47): 114370
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"We would like to express our sincere gratitude to the editorial team and all reviewers for their invaluable efforts in the publication ..."
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"We would like to express our sincere gratitude to the editorial team and all reviewers for their invaluable efforts in the publication of this paper. Your meticulous reviews, constructive suggestions and efficient processing have greatly improved the quality and rigor of our work. Your professional insights and patient guidance helped us refine our arguments, clarify ambiguities and enhance the overall coherence of the manuscript. We truly appreciate the time, expertise and dedication you devoted to supporting academic communication. This paper could not have been published smoothly without your earnest contributions, and we will continue to uphold rigorous academic standards in our future research. Thank you again for your invaluable support! "
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Cheng X, Yin XL, Shan YQ, Wang SY, Xia YB, Xu B, Xu TC. Navigating heart failure medications in obstetric practice. World J Obstet Gynecol 2025; 14(3): 112710
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"The editorial and peer-review process was conducted in a highly professional, transparent, and efficient manner. Communication with ..."
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"The editorial and peer-review process was conducted in a highly professional, transparent, and efficient manner. Communication with the editorial office was clear and timely throughout all stages of submission, revision, and production. The comments and suggestions provided by the editorial team were constructive and contributed meaningfully to improving the clarity, scientific rigor, and overall quality of the manuscript. Overall, the publishing experience was smooth, well organized, and satisfactory. "
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Jovanovic P. Insertion time as a proxy for procedural complexity: Refining its role in predictive models of adenoma detection. World J Gastroenterol 2025; 31(47): 114092
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"We want to thank the Editor-in-Chief, reviewers, and supporting staff for this opportunity to publish our work in your journal. It ..."
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"We want to thank the Editor-in-Chief, reviewers, and supporting staff for this opportunity to publish our work in your journal. It was a great experience. There was cooperation at each step, and we look forward to further publications. We further suggest that the publication period can be shortened by one to two months. "
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Parija S, Chakraborty K, Sahu RN, Nayak B, Rathod RS. Ganglion cell complex and retinal nerve fiber layer thickness in predicting visual outcome in brain tumors after surgery. World J Exp Med 2025; 15(4): 108702
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"I am very grateful for your prompt evaluation of our paper and for publishing it. I have submitted my papers to this journal in the ..."
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"I am very grateful for your prompt evaluation of our paper and for publishing it. I have submitted my papers to this journal in the past and they have been accepted. I would like to continue submitting papers to your journal and disseminating the results of our research. I look forward to your continued support. Toshiyuki Kakinuma "
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Morita A, Kakinuma T, Segawa A, Harada S, Takae S, Tamura M, Suzuki N. Prolonged retention of oil-based iodinated contrast medium observed on plain abdominal radiograph after cesarean section: A case report. World J Clin Cases 2025; 13(29): 110454
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"We, the undersigned authors, express our profound gratitude to the editors of your journal for the high sense of responsibility ..."
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"We, the undersigned authors, express our profound gratitude to the editors of your journal for the high sense of responsibility demonstrated throughout the entire process of our manuscript from submission to publication! Meanwhile, we also offer our sincere apologies for any inconvenience caused to your journal due to our own oversights during the submission process. "
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Li JY, Ge MM, Pan HF, Wang G, Jiang ZW. Feasibility and safety of enhanced recovery after surgery in elderly patients with gastric cancer. World J Gastroenterol 2025; 31(47): 113331
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"The authors express their most sincere gratitude to the assistant editor, science editor, peer reviewers, editorial director, journal ..."
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"The authors express their most sincere gratitude to the assistant editor, science editor, peer reviewers, editorial director, journal editor-in-chief, company editor-in-chief, language editor and production editor, as well as with the full cooperation of all authors for accepting and publication of the results of our study in the prestigious World Journal of Experimental Medicine. We thank the reviewers for their fair critical comments, which allowed us to improve the submitted manuscript. We are very grateful to Science Editor Ji-Hong Liu and Editor-in-Chief Li Li for editing our manuscript and apologize for the typos and errors we made while preparing the manuscript. We express our most sincere gratitude to Founder and Chief Executive Officer, Professor Lian-Sheng Ma for the opportunity to publish in the most prestigious journals of Baishideng Publishing Group Inc. With respect and gratitude, Senchukova MA, Zubareva EY, Saidler NV, Krivolapova LV. "
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Senchukova MA, Zubareva EY, Saidler NV, Krivolapova LV. Lack of cytoplasmic expression of a new marker programmed cell death ligand-1 in tumor cells is significant. World J Exp Med 2025; 15(4): 110890
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"I am fully satisfied with the manuscript processing, review and publishing by the journal. The time taken by the journal for the whole ..."
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"I am fully satisfied with the manuscript processing, review and publishing by the journal. The time taken by the journal for the whole process was adequate. The reviewers' constructive feedback helped us in improving the quality of manuscript. I look forward to getting my more research papers published in the journal. "
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Dhawan R, Mittal R, Kumar A, Laller KS, Gill PS, Rag A, Mittal N. Sacubitril/valsartan as add-on to standard therapy in patients with heart failure: A randomized controlled trial. World J Exp Med 2025; 15(4): 111542
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"Working with the BPG Publishing submission and peer-review system has been a genuinely positive experience. The platform is clear ..."
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"Working with the BPG Publishing submission and peer-review system has been a genuinely positive experience. The platform is clear and practical: the steps are intuitive, required fields are easy to identify, and it is straightforward to upload files, track manuscript status, and respond to editorial requests without unnecessary back-and-forth. Just as importantly, the editorial team has been consistently supportive and responsive. When small issues arise—formatting questions, minor technical points, or clarification around workflow—their communication is prompt, polite, and solution-focused, which makes the process feel collaborative rather than transactional. I am also very pleased with how approachable the team is when coordinating multi-author work and revisions. That type of guidance matters in real life, where clinicians and researchers are balancing clinical load, teaching, and deadlines. From my perspective as a clinician-academic involved in supervision and manuscript development, this level of organization and human support is exactly what encourages ongoing contributions. Finally, I can say the experience has been similarly encouraging for my MSc students at the University of South Wales (in association with Learna). They find the process structured, transparent, and less intimidating than many other systems, which helps build confidence and momentum toward publication. Thanks for you amazing work as usual! "
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Mudege T, Soldera J. Reevaluating aminosalicylates role in maintaining remission in ulcerative colitis: Systematic review and meta-analysis in the era of biologics. World J Meta-Anal 2025; 13(4): 108681
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"We are very pleased to have our manuscript published in the World Journal of Diabetes. The editorial team handled our submission in ..."
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"We are very pleased to have our manuscript published in the World Journal of Diabetes. The editorial team handled our submission in a highly professional and efficient manner throughout the entire process. Peer review was thorough and constructive, and the reviewers’ comments significantly improved the clarity and scientific rigor of our work. Communication from the editorial office was consistently clear and timely, making the revision process smooth and well-organized. We appreciate the journal’s commitment to high standards and would gladly consider it for future submissions. Thank you for the excellent publishing experience. "
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Che XD, Wei ZL, Gong W, Qin L, Liu S, Jin YH, Wang HY. Clinical and genetic characteristics of young-onset diabetes with concurrent mitochondrial m.3243A>G and CEL gene mutations: A case report. World J Diabetes 2025; 16(12): 113238
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"As an authoritative journal in the field of gastroenterology, the World Journal of Gastroenterology (WJG) has always maintained a ..."
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"As an authoritative journal in the field of gastroenterology, the World Journal of Gastroenterology (WJG) has always maintained a rigorous academic attitude and an open research perspective. The journal not only focuses on the latest progress in clinical practice but also actively promotes the combination of basic research and clinical translation, providing a high - quality communication platform for global gastroenterology researchers. The review process is efficient and transparent. The cycle from submission to the feedback of the first - round review comments is approximately 4 - 6 weeks. The communication from the editorial department is timely and professional, which reflects respect and support for the authors. The comments put forward by the three reviewers for this submission are highly constructive. They not only focus on the rigor of the research design (such as the rationality of the sample size and the selection of statistical methods) but also delve into the clinical significance and potential limitations of the research results. These comments have not only helped me improve my paper but also inspired the direction of subsequent research, fully demonstrating the professional competence and sense of responsibility of the reviewers. Overall, the review process of WJG is fair and just, playing a crucial role in improving the quality of papers, and it is a trustworthy academic publication platform. "
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Wu WJ, Wu ZY, Hu DD, Zhou ZG, Chen MS, Zhang YJ, Yang ZY, Chen JB. Comparison of the prognostic value of different inflammation-based scores in patients with hepatocellular carcinoma after Lenvatinib therapy. World J Gastroenterol 2025; 31(47): 113776
20249 items Read more >>
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"The study is particularly strong in its development of a multimodal fusion model that integrates clinical data, radiomics, and habitat ..."
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"The study is particularly strong in its development of a multimodal fusion model that integrates clinical data, radiomics, and habitat imaging to achieve markedly superior performance in predicting early recurrence of hepatocellular carcinoma, outperforming traditional single‑modality models in both accuracy and clinical net benefit. It also excels by incorporating SHAP‑based interpretability to clarify how specific imaging and clinical features contribute to predictions, and by validating meaningful correlations between selected radiomic/habitat features and key pathological markers such as MVI, Ki‑67, and GPC‑3, thereby enhancing biological plausibility and clinical relevance."
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Huang LH, Fang YJ, Zheng XJ, Huang C, Li CL, Yu B, Huang MJ, Qin SJ, Huang DY, Lu DW. Application of multimodal fusion technology in early recurrence prediction and pathological analysis of hepatocellular carcinoma. World J Gastrointest Oncol 2025; 17(12): 114037
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"The study excels by integrating radiomics and body composition metrics from both pretreatment and follow‑up T12‑level CT scans, ..."
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"The study excels by integrating radiomics and body composition metrics from both pretreatment and follow‑up T12‑level CT scans, demonstrating that combining these imaging biomarkers with clinical data markedly improves the accuracy of survival prediction in esophageal cancer. It also stands out for using automated segmentation tools to eliminate manual variability, rigorously comparing multiple machine‑learning models, and showing that follow‑up imaging adds substantial prognostic value. Overall, the research provides a practical, non‑invasive, and clinically applicable framework that enhances personalized risk stratification when traditional L3‑level imaging is unavailable."
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Liu MC, Cheng YY, Lin SC, Lin CH, Chuang CY, Chen WH, Liao CH, Hsieh CH, Hsieh MF, Liu YJ. Machine learning survival prediction in esophageal cancer using radiomics and body composition from pretreatment and follow-up T12-level computed tomography. World J Gastrointest Oncol 2025; 17(12): 112873
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"The study demonstrates several strengths, including the safe and smooth execution of cryoablation without perioperative deaths, the ..."
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"The study demonstrates several strengths, including the safe and smooth execution of cryoablation without perioperative deaths, the clear improvement in immune function and pain reduction following treatment, and the meaningful clinical benefits such as tumor shrinkage and prolonged overall survival compared with chemotherapy alone; together, these findings highlight cryoablation as an effective, minimally invasive option that enhances quality of life and offers a promising therapeutic alternative for patients with locally advanced pancreatic cancer."
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Kang LM, He XL, Lang L, Wang AY, Wang X, Liu YH, Zhao YH, Xu L, Yu FK, Zhang FW. Safety and efficacy of cryoablation in treating locally advanced pancreatic cancer. World J Gastrointest Oncol 2025; 17(12): 113387
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"The study evaluated a WeChat‑based bowel preparation monitoring system for outpatients undergoing colonoscopy and found that, compared ..."
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"The study evaluated a WeChat‑based bowel preparation monitoring system for outpatients undergoing colonoscopy and found that, compared with traditional oral and written education, the digital system significantly reduced patients’ anxiety and depression, improved bowel cleanliness, enhanced key colonoscopy quality indicators such as cecal intubation rate and polyp detection rate, increased patient compliance with dietary and medication instructions, and lowered the incidence of adverse reactions, demonstrating that real‑time, interactive, and personalized guidance can meaningfully improve the overall effectiveness and safety of colonoscopy preparation."
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Xi MJ, Gong YP, Tao J, Li F, Xu MY, Gu X, Bao H, Jiang S, Xu B. Exploring the improvement effect of intestinal network monitoring system on intestinal preparation quality of colonoscopy. World J Gastrointest Oncol 2025; 17(12): 111101
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"The article provides a rigorous and comprehensive meta‑analysis evaluating the prognostic significance of cancer‑associated fibroblasts ..."
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"The article provides a rigorous and comprehensive meta‑analysis evaluating the prognostic significance of cancer‑associated fibroblasts in liver cancer using real‑world clinical data. It strengthens its conclusions through well‑structured subgroup analyses across different CAF markers and cancer types, offering a more nuanced understanding of their prognostic value. The study also adheres to PRISMA guidelines and includes only high‑quality research, enhancing the reliability and credibility of its findings."
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Wei YH, Jiang WJ, Wang SQ, Cai YL, Ma XL. Cancer-associated fibroblasts, clinicopathological characteristics and prognosis of liver cancer: A systematic review and meta-analysis based on real-world research. World J Gastrointest Oncol 2025; 17(12): 110395
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"It was with pleasure that I reviewed the article quality of the following manuscript:
1 Ethics: Not applicable given manuscript ..."
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"It was with pleasure that I reviewed the article quality of the following manuscript:
1 Ethics: Not applicable given manuscript type
2 Methods: Not applicable given manuscript type
3 Results: Not applicable given manuscript type
4 Figures and tables: Not applicable - non included
5 Biostatistics: Not applicable given manuscript type
6 References: References are appropriate/up to date
7 Language: Concise/well written manuscript
8 Caveats or drawbacks: None "
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Turan B. Prognostic impact of tumor deposits in colorectal cancer. World J Gastroenterol 2025; 31(47): 114506
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" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..."
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" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied"
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Ding YZ, Tang DQ, Zhao XJ. Esophageal fistula after resection of giant mediastinal liposarcoma: A case report. World J Clin Cases 2025; 13(35): 115410
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"This is a very interesting paper. I ask some questions for you.When comparing clip-E-CIGARETTES andEUS-C+G, the varicella obliteration ..."
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"This is a very interesting paper. I ask some questions for you.When comparing clip-E-CIGARETTES andEUS-C+G, the varicella obliteration rate is 91.7% and 94.4%,respectively and rebleeding is 23.6% and 19.4%,respectively,suggesting that Clip-ECI has a slightly lower success rate.Please also consider Clip-ECI and EUS-C+G from the point of cost and procedure time.How do you deal with rebleeding cases after endoscopic procedure?Also ,please tell us about cases where endoscopic treatment is difficult."
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Giri S, Kumar K. Gastric varices management: Is clip-assisted glue injection a real-world alternative to endoscopic ultrasound-guided therapy? World J Gastroenterol 2025; 31(46): 114149
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"In recent years, knowledge of the diagnostic and therapeutic roles of stem cells in many digestive system diseases has increased ..."
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"In recent years, knowledge of the diagnostic and therapeutic roles of stem cells in many digestive system diseases has increased dramatically. Stem cells, with their inherent self-renewal and differentiation capabilities, can expand the therapeutic possibilities of modern gastroenterology across varied diagnostic and therapeutic fields. For example, as the authors of this review report, liver organoids derived from human pluripotent stem cells are used for diverse liver cancer remodeling and drug-sensitivity testing. Furthermore, mesenchymal stem cells/stromal cells are used in clinical/therapeutic studies for a large number of liver diseases. It is known that liver diseases (benign and malignant) result in high morbidity and mortality in all countries of the world. The financial burden on international health systems is becoming increasingly unsustainable in many countries, even in those that are highly developed economically. The implementation of stem cell-based diagnosis and treatment strategies for liver diseases is expected to become a reality in the near future, with visible consequences not only in the successful care of patients but also in improving healthcare economic parameters.
"
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Wang YX, Ren YN, Zhang SS, Sun S, Xu MY, Wei T, Zhang LS. Application of stem cells in the precise diagnosis and treatment of liver diseases. World J Gastroenterol 2025; 31(46): 114415
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"1. This review presents a thorough and timely overview of stem cell-based strategies in the diagnosis, modeling and treatment of liver ..."
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"1. This review presents a thorough and timely overview of stem cell-based strategies in the diagnosis, modeling and treatment of liver diseases. The authors have gathered an impressive volume of literature and have covered a wide spectrum of topics that range from pluripotent stem cell differentiation to organoid systems and clinical applications. One of the most notable strengths of the manuscript is the inclusion of clinical trial information, which has been organized into clear and informative tables that greatly enhance the translational relevance of the work. Although the content is comprehensive and highly informative, the overall narrative would benefit from more concise expression because certain sections contain repeated explanations and overly detailed descriptions that affect readability.
2. References：The manuscript contains a rich and extensive reference list, which reflects careful and comprehensive literature collection. This is a clear advantage of the review and provides the reader with broad and current coverage of relevant studies.
3. Language：The manuscript generally uses appropriate scientific terminology and conveys complex concepts accurately. However, the writing occasionally becomes verbose and repetitive. Several paragraphs contain long and heavily structured sentences, repeated connective phrases and extensive lists of factors or markers. These patterns interrupt the natural flow of the text and make some sections difficult to read. A more concise presentation of key ideas and smoother transitions between paragraphs would help strengthen the clarity and coherence of the manuscript. Reducing repeated descriptions of differentiation procedures, signaling pathways and mesenchymal stem cell mechanisms would particularly improve the overall fluency.
4. Figures and tables：The figures and tables play a helpful role in supporting the manuscript. The tables summarizing differentiation methods and clinical trials are especially informative and make complex information more accessible to readers. Some figures contain a large amount of condensed information and many abbreviations, which may make them difficult to interpret at a glance. However, the authors have provided all the abbreviations right next to each table, which is very good. In addition, figure 2 that integrates the major mechanisms and introduction of stem cell-based liver organoids is exquisite visually but may require further editing conceptually.
5. Caveats or drawbacks：
Although the review provides extensive information, it relies heavily on descriptive summaries and would benefit from deeper analytical discussion. Several important challenges are mentioned only briefly, such as heterogeneity among stem cell sources, safety considerations in clinical translation, variability of organoid systems and the limited outcomes of early clinical studies. A more thorough examination of these issues would give the review greater authority and balance.
Overall, the manuscript offers a rich collection of information and valuable resources, especially through its comprehensive references and clinical trial summaries. The quality of the paper would be further improved by tightening the language, and reducing redundancy.
I would like to comment a little bit more at the end of this ‘Track article quality’ section. The review appropriately highlights stem cell derived exosomes and extracellular vesicles, which is a valuable component of the manuscript. As far as current knowledge suggests, multiple clinical trials involving exosomes or other extracellular vesicle based therapeutics are actively underway. These vesicle based preparations may offer functional advantages comparable to their parental stem cells, while potentially avoiding several practical and safety related challenges associated with cell based therapies, including difficulties in storage, risks of uncontrolled proliferation, and concerns related to tumorigenesis. Given these advantages, a more extensive discussion of exosomes, extracellular vesicles, and their clinical development would further strengthen the manuscript. This topic may be an excellent focus for the authors to expand upon in their future work. Considering the comprehensive scope and overall quality of this review, I would also recommend it for recognition or award within the journal.
"
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Wang YX, Ren YN, Zhang SS, Sun S, Xu MY, Wei T, Zhang LS. Application of stem cells in the precise diagnosis and treatment of liver diseases. World J Gastroenterol 2025; 31(46): 114415
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"The authors express concern about the lack of detailed analysis of the depth of analysis, i.e., tumor miss rates, machine learning ..."
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"The authors express concern about the lack of detailed analysis of the depth of analysis, i.e., tumor miss rates, machine learning model complexity, and dataset quality. They also discuss future directions for the potential of AI in endoscopy training to facilitate skill development and improve the overall proficiency of endoscopists, a crucial area for the future adoption of AI in clinical practice. For AI endoscopy to further develop, we need to work on updating image data and deep learning."
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Fogas CR, Balassone V. Artificial intelligence in gastrointestinal endoscopy: Focus on analytical depth and endoscopist training. Artif Intell Gastrointest Endosc 2025; 6(4): 115140
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"AI is an important milestone for future development in medicine and science. Nonetheless, there are many AI models and each model ..."
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"AI is an important milestone for future development in medicine and science. Nonetheless, there are many AI models and each model has its own learning objectives. Incorporation of multiple AI models and training machine/ learning can greatly enhance the accuracy and readiness of using it to help in hepatopathy. Also, there are many hepatopathy and a systematic way to categories them will be a challenging act."
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Sun JR, Sun XN, Lu BJ, Deng BC. Artificial intelligence in hepatopathy diagnosis and treatment: Big data analytics, deep learning, and clinical prediction models. World J Gastroenterol 2025; 31(45): 111176
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"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..."
[Read more]
"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Wu PE, Chen PJ, Su WC, Chang TK, Chen YC. Perforated sigmoid colon diverticulitis initially presenting with pneumoperitoneum, pneumoretroperitoneum, and pneumomediastinum: A case report. World J Clin Cases 2025; 13(34): 112593
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"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..."
[Read more]
"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Deng X, Lv LY, Jiang SX, Huang JX, Chen XY, Zhang MF, Qi J, Yang M. Low-grade appendiceal mucinous neoplasm: A case report. World J Clin Cases 2025; 13(34): 111668
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"With all due respect, this case shouldn't have been accepted for publication. I lacks complete originality and shows lots of ..."
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"With all due respect, this case shouldn't have been accepted for publication. I lacks complete originality and shows lots of contradictions. That is, the title contradicts the case itself. Initially presenting with Pneumoperitoneum and the cases report indicates that the patient had "three (3) days" with lower abdominal pain. Irregardless of that, whatever clinical presentation, this case shows nothing new that has previously been reported. In conclusion this case report lacks complete originality."
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Wu PE, Chen PJ, Su WC, Chang TK, Chen YC. Perforated sigmoid colon diverticulitis initially presenting with pneumoperitoneum, pneumoretroperitoneum, and pneumomediastinum: A case report. World J Clin Cases 2025; 13(34): 112593
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"First of all, congratulations on the publication of your paper. I have read it carefully, and I found it to be extremely well written, ..."
[Read more]
"First of all, congratulations on the publication of your paper. I have read it carefully, and I found it to be extremely well written, highly educational, and truly informative for readers. For these reasons, I would like to award this paper the first prize. I hope you will continue to produce such valuable work in the future. Thank you very much."
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Usuda D, Furukawa D, Imaizumi R, Ono R, Kaneoka Y, Nakajima E, Kato M, Sugawara Y, Shimizu R, Inami T, Kawai K, Matsubara S, Tanaka R, Suzuki M, Shimozawa S, Hotchi Y, Osugi I, Katou R, Ito S, Mishima K, Kondo A, Mizuno K, Takami H, Komatsu T, Nomura T, Sugita M. Recurrence of acyclovir-resistant herpes encephalitis in an immunocompromised patient: A case report. World J Clin Cases 2025; 13(34): 111438
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"At the Baveno VII consensus workshop has defined the concept of recompensation of decompensated liver cirrhosis. It implies that after ..."
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"At the Baveno VII consensus workshop has defined the concept of recompensation of decompensated liver cirrhosis. It implies that after elimination of the etiological factor, there is at least a partial regression of structural and functional disorders in the liver, reduction of portal pressure with a positive effect on portal hypertension related complications. Many studies have shown the efficacy of direct acting antivirals (DAAs) in achieving recompensation of HCV-related decompensated liver cirrhosis. The authors confirmed these data in Egyptian patients."
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Abdel Hafez RS, Semeya AA, Elgamal R, Othman AA. Direct-acting antiviral therapy reduces variceal rebleeding and improves liver function in hepatitis C virus-related cirrhosis: A multicenter retrospective cohort study. World J Hepatol 2025; 17(11): 110638
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"This is a comprehensive and well-structured review that effectively synthesizes the complex landscape of MASLD in Egypt. The authors ..."
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"This is a comprehensive and well-structured review that effectively synthesizes the complex landscape of MASLD in Egypt. The authors have articulated the convergence of risk factors, diagnostic challenges, and management gaps, positioning MASLD as a critical public health priority. The article's strength lies in its contextualization of the problem within Egypt's unique epidemiological and socioeconomic backdrop, particularly the interplay with the legacy of HCV and nutritional transitions. The inclusion of figures illustrating the multifactorial risks enhances the manuscript's clarity and impact.
There are several inherent challenges remain unresolved. The review points out that studies evaluating the prevalence of MASLD in Egypt are scarce and often include small numbers, and the prevalence and impact of key genetic variants (e.g., PNPLA3, TM6SF2) in the Egyptian population remain underexplored. The natural history and progression rates of MASLD specifically within the Egyptian population are not well-defined due to the absence of longitudinal cohort studies.
The authors have already laid out a roadmap for future research. They intend to advocate for and potentially lead large-scale, population-based epidemiological studies. The appropriate methodology like a stratified cluster sampling design, and the non-invasive diagnostics like FibroScan, could ensure the accuracy to assess the prevalence and fibrosis stages.
The review by Abdelhamed et al. is a powerful call to action, raising interest in non-communicable disease like MASLD in Egypt, and providing an evidence-based argument for a public health-oriented approach to a complex disease. "
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Abdelhamed W, Amin M, Waked I, El-Kassas M. Metabolic dysfunction-associated steatotic liver disease in Egypt: Epidemiology, risk factors and management challenges. World J Gastroenterol 2025; 31(45): 111643
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"This manuscript showed the cellular mechanisms of pentadecanoic acid as an odd-number fatty acid. The presented figures are interesting ..."
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"This manuscript showed the cellular mechanisms of pentadecanoic acid as an odd-number fatty acid. The presented figures are interesting and include valuable information, especially Figure 2, which shows the relation between pentadecanoic acid and cell signaling. In this figure, Mek/ERk and JAK/STAT pathways were shown as the pathways in which pentadecanoic acid was engaged."
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Mercola J. Molecular and cellular mechanisms of pentadecanoic acid. World J Biol Chem 2025; 16(4): 111258
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"This manuscript showed biomarkers for Gestational diabetes mellitus, which is an important metabolic disorder in pregnancy. The authors ..."
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"This manuscript showed biomarkers for Gestational diabetes mellitus, which is an important metabolic disorder in pregnancy. The authors have shown the biochemical parameters of the healthy and diabetic participants. This is a good point. The authors also showed a good agarose electrophoresis of PCR products. In addition, the gene expression of gene variants was studied and proved as biomarkers of
Gestational diabetes mellitus.
"
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Shamsad A, Gautam T, Singh R, Banerjee M. CD36 fatty-acid-transporter gene variants-CD36 G/A (rs1761667) and CD36 C/T (rs75326924) as biomarkers for risk-prediction in gestational diabetes mellitus. World J Biol Chem 2025; 16(4): 111104
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Peer-Reviewers and Manuscript Statistics
- Editorial board members
- 2264
- Peer-reviewers
- 35200
- Manuscripts received today
- 12
- Manuscript reviews today
- 18
- Unhandled manuscripts today
- 211
- Active peer-reviewers today
- 2765
- Reviewer acceptance today
- 32
- Reviewer refusals today
- 59
- Total accepted manuscripts
- 39183
- Total rejected manuscripts
- 44069
- Total peer-reviewers
- 4585970
- Total submissions
- 37146
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1
"This article addresses an important and timely topic: differentiation-based strategies for colorectal cancer (CRC) therapy using ..."
[Read more]
"This article addresses an important and timely topic: differentiation-based strategies for colorectal cancer (CRC) therapy using natural products. The authors present a comprehensive in vitro study suggesting that Ferula assafoetida (FA) induces differentiation and apoptosis in Caco-2 colon cancer cells, potentially via activation of the JNK/MAPK pathway. As a reader, the work is interesting, methodologically broad, and conceptually aligned with current interests in natural compound–based cancer therapeutics, although certain conceptual and interpretative gaps limit its translational impact. As a reader, I would regard this article as a useful exploratory study that justifies further mechanistic, protein-level, and in vivo investigations, rather than a conclusive demonstration of FA as a differentiation therapy for CRC. "
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Abdelsalam HM, Abdelghany AM, Ahmed WA, Diab AA, Abdellateif MS. Ferula assafoetida induced colon cancer cells differentiation through JNK/MAPK signalling pathway activation. World J Exp Med 2025; 15(4): 110757
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"his retrospective study by Cooper et al. provides a valuable comparison of endoscopic band ligation (EBL) and endoscopic thermal ..."
[Read more]
"his retrospective study by Cooper et al. provides a valuable comparison of endoscopic band ligation (EBL) and endoscopic thermal therapy (ETT) as initial treatments for nodular gastric antral vascular ectasia (GAVE), a rare and challenging subtype. The analysis of 37 patients demonstrates that EBL outperforms ETT, with significantly higher clinical remission rates (90% vs. 69%, P=0.041), shorter treatment intervals (172 vs. 928 days, P=0.013), and fewer required endoscopic sessions (1.95 vs. 5.56, P=0.009), supported by improved hemoglobin levels and reduced transfusions. The findings robustly advocate for EBL as a first-line approach due to its efficiency and lower treatment burden. However, limitations include the small sample size, single-center design, and retrospective nature, which may affect generalizability. Despite this, the study fills a critical gap in nodular GAVE management and underscores the need for prospective multicenter trials to validate EBL's superiority and optimize clinical protocols. "
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Cooper JA, Statham E, Holyfield A, Shoreibah MG, Peter S. Initial treatment approaches for nodular gastric antral vascular ectasia: A comparison of endoscopic band ligation and thermal therapies. World J Gastrointest Endosc 2025; 17(12): 111872
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"The minireview by El Dada et al. offers a timely synthesis of endoscopic ultrasound (EUS)-guided coil embolization for gastric varices ..."
[Read more]
"The minireview by El Dada et al. offers a timely synthesis of endoscopic ultrasound (EUS)-guided coil embolization for gastric varices (GVs), highlighting its potential as a safer, precise alternative to traditional therapies like cyanoacrylate injection. Strengths include systematic comparisons with meta-analytic data (e.g., 96.7% obliteration rate for EUS-coil/cyanoacrylate vs. 70.6% for cyanoacrylate alone), practical technical details (coil selection, Doppler confirmation), real-world case illustrations, and cost-effectiveness analysis (1,831vs.11,000 hospitalization). However, limitations persist: reliance on retrospective/single-center data, absence of randomized controlled trials (RCTs) against TIPS/BRTO, and lack of long-term (>5 years) rebleeding/complication data (e.g., coil migration). The authors appropriately call for multicenter RCTs to standardize protocols, explore material combinations, and integrate predictive biomarkers. Despite gaps, the review compellingly argues for EUS-coil’s inclusion in GV guidelines, serving as a valuable reference for advancing therapeutic endoscopy with balanced analysis of efficacy, safety, and accessibility. "
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El Dada A, El Khoury M, Stephan P, Nehme F. Endoscopic ultrasound-guided coil embolization for gastric varices: A promising alternative to traditional therapies. World J Gastrointest Endosc 2025; 17(12): 110168
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"Name of Journal: World Journal of Gastroenterology Manuscript Type: LETTER TO THE EDITOR Dialister-Associated Succinate Dysregulation ..."
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"Name of Journal: World Journal of Gastroenterology Manuscript Type: LETTER TO THE EDITOR Dialister-Associated Succinate Dysregulation in Crohn’s Disease: Clinical and Therapeutic Implications 1Fotios S. Fousekis, 1Konstantinos H. Katsanos, 2Konstantinos Vlachos, 2Georgios D. Lianos 1Department of Gastroenterology, University Hospital of Ioannina, University of Ioannina Ioannina, Greece 2Department of Surgery, University Hospital of Ioannina, University of Ioannina, Greece Corresponding author: Fotios S. Fousekis, MD, PhD, Department of Gastroenterology, University Hospital of Ioannina, University of Ioannina Ioannina, Greece, email: fotisfous@gmail.com Abstract Growing evidence suggests that altered gut microbiota–derived succinate metabolism plays an important role in Crohn’s disease activity and postoperative recurrence. Particular emphasis is placed on Dialister, a gut bacterial genus that consumes succinate inefficiently, potentially leading to its accumulation and increased intestinal inflammation. Elevated succinate may impair immune regulation and enhance inflammatory signaling through SUCNR1 activation and hypoxia-inducible factor-1α stabilization. Recent findings identifying specific Dialister strains associated with postoperative recurrence provide new insight into disease monitoring and risk stratification. Although the study offers an integrative view linking microbial composition, metabolism, and inflammation, further validation using direct metabolomic and shotgun metagenomic approaches is needed. Overall, succinate appears to be a promising biomarker and therapeutic target, supporting future microbiota- and metabolism-based strategies for the management of inflammatory bowel disease. Key words: Crohn’s disease; Inflammatory bowel disease; Gut microbiota; Succinate; Dialister; Postoperative recurrence Core tip Accumulation of the microbial metabolite succinate is increasingly recognized as a key driver of inflammation in Crohn’s disease. Recent evidence links Dialister enrichment to impaired succinate clearance, disease activity, and postoperative recurrence, highlighting succinate as a promising biomarker and therapeutic target in inflammatory bowel disease. To the editor Dialister, an anaerobic Gram-negative genus of the human gut microbiome, has gained clinical interest due to its role in succinate metabolism. While capable of utilizing succinate as a substrate for propionate production, Dialister exhibits relatively slow consumption rates compared with efficient succinate consumers such as Phascolarctobacterium. This inefficiency may result in elevated luminal succinate levels, particularly in the context of inflammatory bowel disease (IBD) (1). Succinate accumulation may disrupt regulatory T cell (Treg) function by promoting FOXP3 degradation, thereby reducing immune tolerance and further amplifying inflammation (2). Furthermore, elevated succinate stabilizes hypoxia-inducible factor-1α (HIF-1α) by inhibiting prolyl hydroxylase activity, which prevents HIF-1α degradation and leads to enhanced inflammatory gene expression and perpetuation of tissue injury, particularly in IBD (3). We read with great interest the recently published article by Boronat-Toscano and colleagues on Dialister-driven succinate accumulation and its association with disease activity and postoperative recurrence in Crohn’s disease (4). This study offers valuable insights into a rapidly growing field of research that links gut microbiota, host metabolism, and inflammation. It positions succinate not just as a metabolic by-product but also as a functional biomarker and potential therapeutic target. One of the major strengths of this work is its integrative, multi-level approach, which combines clinical and biochemical measures of disease activity, such as the Harvey–Bradshaw Index, C-reactive protein, and fecal calprotectin, with gut microbiome profiling using 16S rRNA sequencing and host molecular markers related to succinate signaling, specifically the expression of the succinate receptor SUCNR1 (4). Notably, this study highlights specific Dialister operational taxonomic units (OTUs) in the intestinal mucosa that correlate with the risk and severity of postoperative recurrence. This goes beyond existing knowledge by identifying strain-level microbial signatures with potential predictive value, suggesting that variability within Dialister is vital for patient stratification and disease progression after surgery. The authors also propose a mechanism for succinate accumulation in Crohn's disease, involving the downregulation of NADH dehydrogenase and the upregulation of fumarate reductase and succinate transporters. This metabolic shift enhances succinate production and export by the gut microbiota (4). Despite these strengths, we would like to highlight several issues that merit further discussion. The functional analysis of the gut microbiome is based on predictive approaches (PICRUSt2) rather than on direct measurements of metabolic fluxes or shotgun metagenomic sequencing. Validation of these predictions is essential for robust conclusions. Targeted metabolomic analyses, using mass spectrometry or nuclear magnetic resonance, allow for direct quantification of metabolites as succinate and can confirm the functional activity of predicted pathways (5). In addition shotgun metagenomic sequencing may provide a more comprehensive and direct assessment of the genetic potential for metabolic pathways, including those involved in succinate production and consumption, by sequencing all microbial DNA present in a sample (6). These findings also open important avenues for future research and therapeutic development in inflammatory bowel disease. Given the central role of succinate in promoting intestinal inflammation through SUCNR1 activation and HIF-1α stabilization, strategies aimed at reducing succinate accumulation or blocking its downstream signaling pathways warrant further investigation. Microbiota-targeted interventions, including dietary fiber enrichment, prebiotics, and probiotics designed to enhance the abundance of efficient succinate-consuming bacteria such as Phascolarctobacterium, represent a particularly promising approach, as preclinical studies have demonstrated their ability to lower succinate levels, attenuate inflammatory signaling, and restore epithelial barrier integrity (7). Avoiding supplementation of the diet with refined inulin may be considered, as evidence from mouse models suggests that it can induce abnormal succinate accumulation in the intestinal lumen, thereby contributing to colonic inflammation (8). In parallel, pharmacological inhibition of SUCNR1 using small-molecule antagonists, as well as interventions targeting HIF-1α stabilization, may offer complementary strategies to suppress succinate-driven inflammation (9, 10). Huo et al. demonstrated that the SUCNR1 inhibitor NF-56-EJ40 may suppress glycolysis in intestinal epithelial cells and attenuates Th17-mediated inflammation in a dextran sodium sulfate–induced mouse model of ulcerative colitis. Treatment reduced pro-inflammatory cytokine production, improved epithelial barrier integrity, and alleviated colonic injury, supporting SUCNR1 antagonism as a therapeutic strategy targeting both metabolic and immune pathways (7). Consistently, genetic deletion of SUCNR1 in mice protected against both acute colitis and intestinal fibrosis, while in human fibroblasts derived from Crohn’s disease patients, succinate increased SUCNR1 expression and promoted inflammatory and fibrotic markers that were effectively reversed by SUCNR1 blockade (11). While these approaches are supported by growing mechanistic and translational evidence, well-designed clinical trials will be essential to determine their efficacy and safety in patients with IBD. Conclusion The study conducted by Boronat-Toscano et al. enhances the understanding of how microbiota-driven metabolic dysregulation relates to Crohn’s disease by identifing succinate and Dialister-associated microbial signatures associated as important factors that influence disease activity and the likelihood of postoperative recurrence. These findings support the use of succinate-related biomarkers in future risk assessment and postoperative monitoring strategies. Additionally, they provide a strong biological basis for therapeutic interventions that target succinate metabolism or SUCNR1-mediated signaling. Overall, this study marks a crucial step towards developing metabolically informed, microbiome-based precision medicine for IBD. Author contributions: Fousekis FS wrote the original draft; Lianos GD contributed to conceptualization, writing, reviewing and editing; Katsanos KH and Vlachos K participated in drafting the manuscript; and all authors have read and approved the final version of the manuscript. References 1. Anthamatten L, von Bieberstein PR, Menzi C, Zund JN, Lacroix C, de Wouters T, Leventhal GE. Stratification of human gut microbiomes by succinotype is associated with inflammatory bowel disease status. Microbiome. 2024;12(1):186. PMID: 39350289 PMCID: PMC11441152 DOI: 10.1186/s40168-024-01897-8 2. Wang H, Hu D, Cheng Y, Gao Q, Liu K, Mani NL, Tang AY, Iyer R, Gao B, Zhou Q, Yu Q, Weinberg SE, Zhang X, Cong Y, Dulai PS, Zhang Y, Liu Z, Fang D. Succinate drives gut inflammation by promoting FOXP3 degradation through a molecular switch. Nat Immunol. 2025;26(6):866-80. PMID: 40457062 PMCID: PMC12399925 DOI: 10.1038/s41590-025-02166-y 3. Tannahill GM, Curtis AM, Adamik J, Palsson-McDermott EM, McGettrick AF, Goel G, Frezza C, Bernard NJ, Kelly B, Foley NH, Zheng L, Gardet A, Tong Z, Jany SS, Corr SC, Haneklaus M, Caffrey BE, Pierce K, Walmsley S, Beasley FC, Cummins E, Nizet V, Whyte M, Taylor CT, Lin H, Masters SL, Gottlieb E, Kelly VP, Clish C, Auron PE, Xavier RJ, O'Neill LAJ. Succinate is an inflammatory signal that induces IL-1beta through HIF-1alpha. Nature. 2013;496(7444):238-42. PMID: 23535595 PMCID: PMC4031686 DOI: 10.1038/nature11986 4. Boronat-Toscano A, Queipo-Ortuño MI, Monfort-Ferré D, Suau R, Vañó-Segarra I, Valldosera G, Cepero C, Astiarraga B, Clua-Ferré L, Plaza-Andrade I, Aranega-Martín L, Cabrinety L, Abadia de Barbarà C, Castellano-Castillo D, Moliné A, Caro A, Domènech E, Sánchez-Herrero JF, Benaiges-Fernandez R, Fernández-Veledo S, Vendrell J, Ginés I, Sumoy L, Manyé J, Menacho M, Serena C. Dialister-driven succinate accumulation is associated with disease activity and postoperative recurrence in Crohn's disease. World J Gastroenterol. 2025;31(45):112618. PMID: 41378335 PMCID: PMC12687013 DOI: 10.3748/wjg.v31.i45.112618 5. Han S, Van Treuren W, Fischer CR, Merrill BD, DeFelice BC, Sanchez JM, Higginbottom SK, Guthrie L, Fall LA, Dodd D, Fischbach MA, Sonnenburg JL. A metabolomics pipeline for the mechanistic interrogation of the gut microbiome. Nature. 2021;595(7867):415-20. PMID: 34262212 PMCID: PMC8939302 DOI: 10.1038/s41586-021-03707-9 6. Mitra S, Forster-Fromme K, Damms-Machado A, Scheurenbrand T, Biskup S, Huson DH, Bischoff SC. Analysis of the intestinal microbiota using SOLiD 16S rRNA gene sequencing and SOLiD shotgun sequencing. BMC Genomics. 2013;14 Suppl 5(Suppl 5):S16. PMID: 24564472 PMCID: PMC3852202 DOI: 10.1186/1471-2164-14-S5-S16 7. Huo L, Chen Q, Jia S, Zhang Y, Wang L, Li X, Li Z, Sun B, Shan J, Lin J, Yang L, Sui H. Gut microbiome promotes succinate-induced ulcerative colitis by enhancing glycolysis through SUCNR1/NF-kappaB signaling pathway. Am J Physiol Cell Physiol. 2025;329(2):C440-C54. PMID: 40549551 DOI: 10.1152/ajpcell.00411.2025 8. Tian S, Paudel D, Hao F, Neupane R, Castro R, Patterson AD, Tiwari AK, Prabhu KS, Singh V. Refined fiber inulin promotes inflammation-associated colon tumorigenesis by modulating microbial succinate production. Cancer Rep (Hoboken). 2023;6(11):e1863. PMID: 37489647 PMCID: PMC10644334 DOI: 10.1002/cnr2.1863 9. Haffke M, Fehlmann D, Rummel G, Boivineau J, Duckely M, Gommermann N, Cotesta S, Sirockin F, Freuler F, Littlewood-Evans A, Kaupmann K, Jaakola VP. Structural basis of species-selective antagonist binding to the succinate receptor. Nature. 2019;574(7779):581-5. PMID: 31645725 DOI: 10.1038/s41586-019-1663-8 10. Kim YI, Yi EJ, Kim YD, Lee AR, Chung J, Ha HC, Cho JM, Kim SR, Ko HJ, Cheon JH, Hong YR, Chang SY. Local Stabilization of Hypoxia-Inducible Factor-1alpha Controls Intestinal Inflammation via Enhanced Gut Barrier Function and Immune Regulation. Front Immunol. 2020;11:609689. PMID: 33519819 PMCID: PMC7840603 DOI: 10.3389/fimmu.2020.609689 11. Macias-Ceja DC, Ortiz-Masia D, Salvador P, Gisbert-Ferrandiz L, Hernandez C, Hausmann M, Rogler G, Esplugues JV, Hinojosa J, Alós R; Navarro F, Cosin-Roger J, Calatayud S, Barrachina MD. Succinate receptor mediates intestinal inflammation and fibrosis. Mucosal Immunol. 2019;12(1):178-87. PMID: 30279517 DOI: 10.1038/s41385-018-0087-3 "
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Boronat-Toscano A, Queipo-Ortuño MI, Monfort-Ferré D, Suau R, Vañó-Segarra I, Valldosera G, Cepero C, Astiarraga B, Clua-Ferré L, Plaza-Andrade I, Aranega-Martín L, Cabrinety L, Abadia de Barbarà C, Castellano-Castillo D, Moliné A, Caro A, Domènech E, Sánchez-Herrero JF, Benaiges-Fernandez R, Fernández-Veledo S, Vendrell J, Ginés I, Sumoy L, Manyé J, Menacho M, Serena C. Dialister-driven succinate accumulation is associated with disease activity and postoperative recurrence in Crohn’s disease. World J Gastroenterol 2025; 31(45): 112618
5
"This minireview systematically synthesizes the intricate interplay between depression and gastric cancer (GC), incorporating ..."
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"This minireview systematically synthesizes the intricate interplay between depression and gastric cancer (GC), incorporating neuroendocrine, immunological, and psychosocial mechanisms. The authors effectively underscore the bidirectional causality supported by 52 referenced studies, in alignment with the biopsychosocial model. Nonetheless, there are opportunities to enhance methodological rigor and visual communication. Although Figure 1 delineates key components of the bidirectional relationship, its informational density is suboptimal. The figure lacks a hierarchical structuring of pathways (e.g., neuroendocrine versus immune mechanisms) and does not quantify effect sizes (e.g., hazard ratios from cited meta-analyses). It is recommended to incorporate a summary table for comparison. "
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Chen Z, Gong TJ, Zhao L. Bidirectional relationship between depression and the risk and prognosis of gastric cancer. World J Gastrointest Oncol 2025; 17(12): 113272
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"I want to congratulate the authors, Zhang et al, for conducting a study and identifying the predictors of refractory GERD. They have ..."
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"I want to congratulate the authors, Zhang et al, for conducting a study and identifying the predictors of refractory GERD. They have identified the disease duration and anxiety as significant risk factors and at least 90 minutes of moderate-intensity physical activity per week as a protective factor for refractory GERD. One of the important findings in this study is the association of significant Overlap DGBI symptoms (such as dyspepsia, constipation, and diarrhoea) in at least 50% of GERD patients. Since most patients had a duration of illness of more than 4 years, complications of GERD and their comparison between the groups were not noted in this study (a limitation). Although hydrogen impedance is used for diagnosis, the comparison of impedance parameters is not provided. H pylori infection is a protective factor for GERD/Barrett's, which is also a limitation. This study has provided a meaningful conclusion regarding the association between long-term symptoms and refractoriness. "
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Zhang N, Wang Y, Fang SS, Han M, Zheng QW, Zhu YY, Zhang MY, Li JJ, Cui LX, Tian JL, Deng YH, Zhu SL, Ni HM, Zhou L, Zuo GL, Huang TS, Liao Q, Li XQ, Shang YY, Wang YJ, Tian Y, Ge LY, Han HQ, Hu WM, Jiang Y, Li YJ, Mao X, Yang LH, Yao JM, Zheng X, Wang HW, Fang SQ. Clinical characteristics and risk factors of refractory gastroesophageal reflux disease: A multicenter cross-sectional study. World J Gastroenterol 2025; 31(45): 113060
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"The present Letter provides a concise academic response to the article identified by Reader’s code 05354032. The comments focus on ..."
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"The present Letter provides a concise academic response to the article identified by Reader’s code 05354032. The comments focus on several important aspects of the study, including its methodological design, data interpretation, and clinical applicability. The aim is to offer constructive perspectives that may help clarify key issues and support future improvements in related research. "
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Ardila CM, Ángel-Estrada S, González-Arroyave D. Robot-assisted vs conventional lumbar interbody fusion: A systematic review and meta-analysis of perioperative, radiographic, and clinical outcomes. World J Orthop 2025; 16(11): 110276
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"The study title "Comparison of the efficacy of laparoscopic hepatectomy and radiofrequency ablation for small hepatocellular ..."
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"The study title "Comparison of the efficacy of laparoscopic hepatectomy and radiofrequency ablation for small hepatocellular carcinoma: A retrospective study" by Lei et al. aims to compare the long-term survival and perioperative outcomes of Laparoscopic hepatectomy (LH) and radiofrequency ablation (RFA) for small hepatocellular carcinoma (HCC). This retrospective study included 254 patients with small HCC who were collected from Hospital of Chongqing Medical University between December 2022 and March 2025. The results showed that LH was associated with longer operative time, greater blood loss, prolonged recovery, higher costs, and increased complication rates. Consequently, LH, though associated with increased perioperative morbidity, provides superior long-term survival outcomes compared with RFA in patients with small HCC. This study had many limitations such as potential for selection bias and confounding factors that were not controlled for is inherent. The decision to undergo either LH or RFA was made based on clinical judgment and patient-specific factors, which could introduce bias. The sample size was still be insufficient to detect subtle differences in outcomes between the two modalities, especially for subgroups with specific tumor characteristics or comorbidities. Moreover, LH and RFA techniques have evolved over time, and variations in operator experience and institutional protocols could influence outcomes. "
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Lei ZL, Tan ZL, Luo YH, Yang M, Wang JL, Qin Z, Liu YY. Comparison of the efficacy of laparoscopic hepatectomy and radiofrequency ablation for small hepatocellular carcinoma: A retrospective study. World J Gastroenterol 2025; 31(45): 111540
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"We are delighted to read the high-quality review by Zheng et al[1], published in the World Journal of Gastroenterology, which offers ..."
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"We are delighted to read the high-quality review by Zheng et al[1], published in the World Journal of Gastroenterology, which offers insightful perspectives on the neuroimmune mechanisms contributing to the pathogenesis of inflammatory bowel disease (IBD). The intricate interplay between the autonomic nervous system (ANS) and the immune response, particularly involving vagus nerve stimulation (VNS) and its effects on macrophages, provides a promising avenue for future therapeutic interventions in IBD. The review underscores the emerging concept of neuroimmune interactions, particularly the cholinergic anti-inflammatory pathway (CAIP), which regulates inflammation through the vagus nerve and its interaction with intestinal macrophages. This is an exciting area of research, especially in the context of IBD, where inflammation is at the heart of the disease's pathology. Macrophages, as highlighted in the review, play a crucial role in maintaining intestinal homeostasis, but when overactivated, they contribute to the excessive production of proinflammatory cytokines, exacerbating the condition. This review draws attention to how the cholinergic system can modulate macrophage activity, reducing the inflammatory burden through the activation of the α7 nicotinic acetylcholine receptor (α7nAChR). The role of VNS as an approach to activate the cholinergic pathway and regulate inflammation in IBD is a breakthrough concept. Studies showing the beneficial effects of VNS in reducing inflammation and enhancing immune tolerance are promising, offering a potential alternative to conventional treatments, especially in patients with refractory IBD. Furthermore, the use of VNS to modulate the autonomic nervous system offers a unique therapeutic strategy for restoring balance between sympathetic and parasympathetic tones in patients, whose autonomic dysfunction may contribute to disease exacerbation. While the current data on VNS in IBD are promising, the review rightly calls for further research to better establish the clinical applicability of VNS, especially through non-invasive techniques such as transauricular and transcervical VNS. These methods, as highlighted, may offer a safer and more accessible alternative to invasive VNS, which has shown positive effects in treating other inflammatory conditions. The ongoing exploration of VNS in clinical trials, coupled with advancements in understanding the mechanisms of cholinergic signaling in immune cells, opens new avenues for therapeutic interventions in chronic inflammatory diseases. However, as the review mentions, there are still challenges that need to be addressed. The precise mechanisms through which VNS modulates immune responses, particularly in macrophages, are still under investigation. Additionally, while VNS has shown potential in preclinical models, there is a need for larger, well-designed clinical studies to confirm the safety, efficacy, and long-term benefits of VNS in IBD patients. The heterogeneity of IBD, along with differences in patient responses to treatment, further complicates the development of standardized protocols for VNS treatment. In conclusion, the review provides an excellent overview of the current state of research on neuroimmune interactions in IBD, with a special focus on the potential of VNS as a novel therapeutic strategy. The integration of neuroimmune regulation, particularly through the cholinergic pathway, into the treatment of IBD represents an innovative approach that could offer significant improvements in patient outcomes. As we move forward, I hope that the continued research in this field will provide more concrete evidence to support the use of VNS in clinical practice, potentially offering a transformative treatment for IBD patients who have not responded to traditional therapies. LIMITATIONS OF THE REVIEW While the review provides a comprehensive overview of the potential therapeutic role of vagus nerve stimulation (VNS) in inflammatory bowel disease (IBD), there are some limitations that should be addressed in future research. First, while the article highlights the promising effects of VNS, particularly through the cholinergic anti-inflammatory pathway (CAIP), there is a lack of in-depth discussion regarding the specific cellular mechanisms involved. The exact signaling pathways through which VNS modulates macrophage activity and alters immune responses remain unclear, and more detailed mechanistic studies are needed to provide a clearer understanding. Additionally, the review does not fully address the challenges associated with the translation of VNS into clinical practice. For instance, the variability in patient response to VNS, the optimal stimulation parameters (e.g., frequency, duration, and intensity), and the potential side effects of VNS, particularly in IBD patients with coexisting conditions, are aspects that require more attention. Lastly, the review focuses primarily on the autonomic nervous system's role in IBD, but it overlooks other possible neuroimmune interactions that could also influence disease progression. A broader exploration of how other neural pathways or neuropeptides contribute to IBD would provide a more comprehensive view of the neuroimmune mechanisms at play. CONCLUSION The review provides an insightful exploration of the neuroimmune mechanisms involved in inflammatory bowel disease (IBD), particularly focusing on the role of intestinal macrophages and the cholinergic anti-inflammatory pathway. Vagus nerve stimulation (VNS) represents a promising non-invasive therapeutic approach for modulating the immune system and controlling inflammation in IBD. However, further research is needed to fully understand the mechanisms behind VNS and to establish its efficacy in clinical settings for treating chronic inflammatory diseases such as IBD. With the development of non-invasive VNS technologies, future therapies may offer safer and more effective treatments for patients suffering from IBD. "
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Zheng L, Duan SL. Neuroimmune interactions in inflammatory bowel disease: Role of intestinal macrophages and the cholinergic pathway. World J Gastroenterol 2025; 31(44): 109440
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"This editorial provides a comprehensive and insightful overview of self-expandable metal stents (SEMS) in acute colonic obstruction, ..."
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"This editorial provides a comprehensive and insightful overview of self-expandable metal stents (SEMS) in acute colonic obstruction, standing out for its clinical relevance and systematic organization. The authors adeptly synthesize cutting-edge techniques (e.g., fluoroscopy-free stenting, two-person colonoscopy) and critical considerations like stent design selection, backed by high-quality recent evidence, which offers valuable guidance for clinical practice. The discussion of complications and mitigation strategies is pragmatic, while the exploration of future directions (e.g., zero-border stents, multidisciplinary collaboration) reflects a forward-thinking perspective. The academic expression is precise and fluent, with consistent use of professional terminology and clear logical progression. A minor suggestion is to include brief comparative data on cost-effectiveness among different stenting techniques or stent types, which would further assist healthcare institutions in decision-making. Overall, this is a high-quality, clinically impactful piece that serves as an excellent reference for gastroenterologists and surgeons specializing in colorectal disorders. "
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Sun HY, Li ZC, Wang HL. Current mechanisms and techniques for placement of self-expandable metal stents in acute colonic obstruction. World J Gastrointest Surg 2025; 17(11): 110512
11
"The editorial authored by Watanabe presents a timely and clinically pertinent overview of lisocabtagene maraleucel (liso-cel) CAR-T ..."
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"The editorial authored by Watanabe presents a timely and clinically pertinent overview of lisocabtagene maraleucel (liso-cel) CAR-T therapy, specifically addressing nodal and gastrointestinal follicular lymphoma (GI-FL). The author skillfully amalgamates essential findings from the TRANSCEND FL trial, emphasizing the extraordinary 97% overall response rate and a 94% complete response rate, alongside a notably reduced toxicity profile where grade ≥3 cytokine release syndrome (CRS) was absent, and grade ≥3 neurotoxicity was observed in merely 3% of patients. This concentrated analysis on the unique advantages of liso-cel—particularly its defined CD4+/CD8+ composition and the feasibility of outpatient treatment—addresses a significant void in the existing literature, especially in light of the historical exclusion of GI-FL from crucial CAR-T trials. The comparative framework juxtaposing lisocabtagene maraleucel with axicabtagene ciloleucel and tisagenlecleucel provides invaluable insights for clinical decision-making. Nevertheless, the editorial's otherwise robust examination fails to explore subtleties regarding the durability of response in high-risk subpopulations. Although the reported 12-month progression-free survival rate exceeding 85% is promising, emerging data indicate that follicular lymphoma patients with specific genomic alterations (e.g., TP53 mutations or 1p36 deletions) display varied responsiveness to CAR-T therapy. This omission is particularly salient for GI-FL, where the biological characteristics of the disease may diverge from those of nodal FL due to influences from the microenvironment. Furthermore, the editorial rightly recognizes cost as a barrier but insufficiently emphasizes how the manufacturing logistics of Liso-Cel disproportionately hinder accessibility in advanced GI-FL cases. Unlike nodal FL, where treatment delays may be manageable, GI-FL frequently presents urgent complications necessitating swift intervention. The three-week manufacturing timeline for liso-cel—despite improvements over previous platforms—remains a challenge for these patients, a difficulty exacerbated by the absence of validated bridging strategies tailored to gastrointestinal involvement. Looking ahead, the integration of endoscopic and molecular staging systems (e.g., Paris classification) with CAR-T therapy response biomarkers emerges as a critical research priority. Real-world studies should specifically investigate GI-FL cohorts to ascertain whether mucosal disease localization influences CAR-T trafficking or persistence. Additionally, the formulation of risk-adapted conditioning regimens could optimize the therapeutic index in patients with gastrointestinal involvement, where organ-specific toxicities remain inadequately characterized. Watanabe's appeal for multicenter collaboration should explicitly encompass these mechanistic and health-services research inquiries to propel personalized CAR-T applications across follicular lymphoma subtypes. "
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Watanabe T. Emerging role of lisocabtagene maraleucel chimeric antigen receptor-T cell in nodal and gastrointestinal follicular lymphoma. World J Gastroenterol 2025; 31(45): 112336
12
"This review elevates our understanding of acetaminophen (APAP)-induced acute liver injury from a “single toxic metabolite acting on ..."
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"This review elevates our understanding of acetaminophen (APAP)-induced acute liver injury from a “single toxic metabolite acting on hepatocytes” model to a dynamic network involving multiple hepatic cell populations. Second, it clearly maps out current and potential therapeutic targets, essentially providing a “cell-type–oriented treatment roadmap” for future translational work. The discussion of CYP2E1/CYP3A4, species differences, and risk factors (such as alcohol use, malnutrition, underlying liver disease, and concomitant enzyme-inducing drugs) helps clinicians better identify high-risk populations and appreciate the limitations of extrapolating from animal models, thereby supporting more individualized risk assessment and dosing. In the treatment section, the authors extend beyond the classical “N-acetylcysteine golden window” and cover emerging strategies such as inhibition of NAPQI formation (e.g. fomepizole), mitochondria-targeted antioxidants (Mito-Tempo, MitoQ), modulation of ferroptosis/ferritinophagy, NLRP3–STING inflammasome pathways, as well as cell-based and hepatocyte transplantation therapies. This allows clinical readers to quickly grasp potential combination or alternative approaches that are entering or approaching clinical trials, while signaling to basic scientists multiple promising cellular pathways and targets for deeper exploration. Overall, the article reads as an up-to-date progress review on the multicellular mechanisms and therapeutic targets of APAP-induced acute liver injury, offering both mechanistic clarity and topic inspiration for those working on drug-induced liver injury, emergency/critical care, and liver transplantation—while also realistically emphasizing that most of the evidence remains at the experimental or early translational stage and is not yet ready to change clinical guidelines. "
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Yang D, Kim B, Kim JW. Mechanistic insights into hepatic cell type-specific contributions to acetaminophen-induced acute liver injury. World J Gastroenterol 2025; 31(45): 112720
13
"this review provides a clear and systematic overview of the interactions among intestinal macrophages, the enteric nervous system, ..."
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"this review provides a clear and systematic overview of the interactions among intestinal macrophages, the enteric nervous system, and the cholinergic anti-inflammatory pathway in inflammatory bowel disease (IBD). By closely linking basic mechanistic insights with the potential clinical application of vagus nerve stimulation (VNS)—especially low-frequency, non-invasive VNS—the paper offers a fresh “neuroregulation–immune modulation” angle on IBD treatment, which is currently dominated by immunosuppressants and biologics. In terms of clinical practicality, the authors emphasize the promise of non-invasive VNS as a safer and more tolerable approach, while frankly acknowledging that current evidence still largely comes from animal models and a few pilot clinical studies, with a lack of large-scale randomized controlled trials. This “promising yet cautious” tone is valuable for clinical readers. On the one hand, the paper helps gastroenterologists and basic scientists understand why heart rate variability (HRV), emotional status, and autonomic imbalance may be linked to IBD course and relapse; on the other hand, it reminds readers that VNS and α7nAChR-targeted agents are still at the stages of proof-of-concept and early translation. In the short term, their main value lies in inspiring new research designs (for example, clinical trials stratified by HRV, combined with intestinal macrophage phenotype analysis), rather than immediately changing standard treatment pathways. Overall, this work reads like a forward-looking “blueprint” for neuro-immune therapies in IBD and is particularly thought-provoking for readers interested in IBD mechanisms and novel therapeutic strategies. "
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Zheng L, Duan SL. Neuroimmune interactions in inflammatory bowel disease: Role of intestinal macrophages and the cholinergic pathway. World J Gastroenterol 2025; 31(44): 109440
14
"Commentary on "Large Language Models and Large Concept Models in Radiology: Present Challenges, Future Directions, and Critical ..."
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"Commentary on "Large Language Models and Large Concept Models in Radiology: Present Challenges, Future Directions, and Critical Perspectives" The transition from LLMs to LCMs, aiming for enhanced semantic reasoning, is fundamentally challenged by the necessity of building these sophisticated models upon historical data streams polluted by human cognitive biases [1]. Diagnostic interpretation errors are often not perceptual misses but interpretive errors driven by faulty reasoning [2,3]. These biases include Anchoring Bias, where a radiologist becomes fixated on an initial impression despite contradictory evidence, often coupled with Confirmation Bias, the inclination to seek information only to affirm that initial theory [2,4,5]. Similarly, Availability Bias, or availability heuristics, predisposes the interpreter to recall recently seen or memorable diagnoses regardless of the actual prevalence [3,4,6]. When AI learns its "concepts" or "relationships" from millions of reports generated under the influence of these specific biases, it may normalize or amplify flawed reasoning patterns, potentially leading to widespread, systemic diagnostic vulnerabilities that mirror rather than correct human limitations [3]. For instance, an AI trained primarily on reports that exhibit Zebra Retreat—the avoidance of accurate but rare diagnoses due to lack of confidence—will systematically underreport uncommon but critical findings, reducing the diagnostic sensitivity for edge cases [2,6]. The core strength of future AI systems must therefore lie not just in conceptual depth but in active debiasing, mitigating the human errors that underpin the training corpus [4,5]. If AI recommendations are opaque, clinicians may fall prey to Blind Obedience or Premature Closure by accepting the machine's initial diagnosis without critical Type 2 analysis [2,6]. To counter this, AI must incorporate the same cognitive forcing strategies used by human interpreters, demanding metacognition ("thinking about thinking") to identify susceptibility to bias [3,4]. Furthermore, AI must specifically address the Hindsight Bias that plagues retrospective quality review [2,6], by ensuring its decision pathways are fully auditable and transparent, allowing for objective assessment of whether an error resulted from inherent data contamination or algorithmic failure. As AI integrates deeper into clinical workflows, its ability to enhance safety hinges on proactively resisting the transfer and propagation of predictable human cognitive limitations [6]. References 1. Merchant SA, Merchant N, Varghese SL, Shaikh MJS. Large language models and large concept models in radiology: Present challenges, future directions, and critical perspectives. World J Radiol. 2025;17(11):114754. [DOI: 10.4329/wjr.v17.i11.114754] 2. Onder O, Yarasir Y, Azizova A, Durhan G, Onur MR, Ariyurek OM. Errors, discrepancies and underlying bias in radiology with case examples: a pictorial review. Insights Imaging. 2021;12:51. [PMID: 33877458. DOI: 10.1186/s13244-021-00986-8] 3. Chen J, Gandomkar Z, Reed WM. Investigating the impact of cognitive biases in radiologists' image interpretation: A scoping review. Eur J Radiol. 2023;166:111013. [PMID: 37541180. DOI: 10.1016/j.ejrad.2023.111013] 4. Busby LP, Courtier JL, Glastonbury CM. Bias in Radiology: The How and Why of Misses and Misinterpretations. Radiographics. 2018;38:236–247. [PMID: 29194009. DOI: 10.1148/rg.2018170107] 5. Gunderman RB. Biases in radiologic reasoning. AJR Am J Roentgenol. 2009;192:561–564. [PMID: 19234247. DOI: 10.2214/AJR.08.1220] 6. Yoon SY, Lee KS, Bezuidenhout AF, Kruskal JB. Spectrum of Cognitive Biases in Diagnostic Radiology. Radiographics. 2024;44:e230059. [PMID: 38843094. DOI: 10.1148/rg.230059] "
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Merchant SA, Merchant N, Varghese SL, Shaikh MJS. Large language models and large concept models in radiology: Present challenges, future directions, and critical perspectives. World J Radiol 2025; 17(11): 114754
15
"The authors present a clinically important case highlighting the coexistence of mixed connective tissue disease (MCTD) and ..."
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"The authors present a clinically important case highlighting the coexistence of mixed connective tissue disease (MCTD) and tuberculosis (TB), a scenario that poses substantial diagnostic challenges in TB-endemic regions. The manuscript is well structured and clearly describes the sequence of clinical events, laboratory workup, and therapeutic decisions. The discussion appropriately emphasizes the overlap between autoimmune manifestations and infectious etiologies, particularly when both present with pulmonary involvement. From an academic standpoint, the case is relevant and contributes meaningfully to the limited global literature examining MCTD–TB coexistence. The authors successfully integrate immunological findings with epidemiological considerations, underscoring the need for high clinical suspicion and comprehensive autoimmune evaluation in complex presentations. The reference list is current and well selected, drawing from both rheumatology and infectious disease literature. The language is generally clear and understandable, although a few sections may benefit from stylistic tightening to improve flow, particularly in the discussion where multiple concepts are presented in close succession. Minor grammatical refinements could enhance readability. The inclusion of comprehensive tables and immunological profiles strengthens the diagnostic clarity of the case. For future research and case documentation, the authors may consider: 1. Providing a more detailed longitudinal follow-up, especially regarding TB status, autoimmune markers, and treatment tapering, as long-term outcomes for MCTD-TB coexistence are not well described in the literature. 2. Elaborating on radiologic findings, given the central role of imaging in differentiating pulmonary TB from autoimmune lung involvement. 3. Discussing possible immunopathological links between chronic infections and autoimmune flare, which could enrich the mechanistic understanding of such overlap syndromes. 4. Addressing medication safety monitoring, particularly concerning hepatotoxicity in the context of ATT combined with corticosteroids and hydroxychloroquine. Overall, this is a valuable clinical contribution that highlights key diagnostic considerations in resource-limited, TB-endemic settings. The manuscript is academically sound, clinically relevant, and will be informative for physicians managing complex autoimmune presentations. "
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Sial F, Basit A, Ghafoor N, Sial W, Basil AM. Mixed connective tissue disease and tuberculosis coexistence as a diagnostic dilemma: A case report. World J Clin Cases 2025; 13(33): 109866
16
"The review by Nian et al. offers a thorough and thoughtfully articulated overview of current insights into Osteopontin (OPN)–mediated ..."
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"The review by Nian et al. offers a thorough and thoughtfully articulated overview of current insights into Osteopontin (OPN)–mediated PI3K/AKT signaling and its pivotal influence on gastrointestinal cancer progression, metastatic behavior, and therapeutic resistance. The authors skillfully synthesize mechanistic and translational findings, underscoring how OPN-driven activation of the PI3K/AKT pathway promotes epithelial–mesenchymal transition, metabolic adaptation, immune escape, and chemoresistance. Their discussion of OPN splice variants, tumor microenvironment interactions, and biomarker-informed therapeutic strategies provides meaningful guidance for advancing precision oncology. A major strength of the review is its emphasis on the inherent complexity and compensatory nature of OPN–PI3K/AKT signaling, which helps explain the challenges associated with single-agent therapeutic approaches. The recommendation to pursue combination strategies—such as pairing PI3K/AKT inhibitors with immune checkpoint blockade or OPN-targeted antibodies—is timely and supported by accumulating preclinical data. Furthermore, the manuscript’s focus on PIK3CA mutation subsets and OPN expression as potential predictive biomarkers may enable more refined patient stratification in future clinical trials. Despite these promising avenues, clinical translation remains constrained. Current trials evaluating PI3K/AKT inhibitors in gastrointestinal malignancies have yielded limited efficacy and notable toxicity, highlighting the need for more rigorous biomarker-driven study designs. Although the review acknowledges these issues, a deeper appraisal of the reasons underlying clinical shortcomings—and the specific contribution of OPN signaling to these obstacles—would further strengthen its clinical impact. In sum, this review provides a valuable contribution by elucidating the diverse oncogenic roles of OPN and outlining strategic paths toward overcoming therapeutic resistance. Continued research into isoform-specific activity, tumor microenvironmental dynamics, and rational combinatorial regimens will be crucial for realizing the therapeutic potential of targeting the OPN–PI3K/AKT axis in gastrointestinal cancers. "
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Nian H, Bai Y, Wang HY, Yu H, Zhang ZL, Shi RH, Zhang S, Wu YB, Zhou DH, Du QC. Targeting the Osteopontin-regulated PI3K/AKT signaling pathway: A molecular approach to overcome drug resistance and metastasis in gastrointestinal tumors. World J Gastrointest Oncol 2025; 17(11): 109923
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"This article presents an interesting retrospective study involving a substantial cohort of patients, highlighting the role of total ..."
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"This article presents an interesting retrospective study involving a substantial cohort of patients, highlighting the role of total neoadjuvant therapy (TNT), specifically the RAPIDO protocol, compared to conventional long-course chemoradiotherapy (LCCRT) in the management of locally advanced rectal cancer (LARC). The study focuses on early surgical outcomes, a topic of significant clinical relevance. The cornerstone of LARC treatment remains optimal surgical resection via total mesorectal excision (TME). To reduce locoregional failure, preoperative concurrent chemoradiotherapy has long been the standard of care. However, as noted in the article and supported by prior evidence (e.g., Fokas et al.), the efficacy of this approach is primarily confined to local control, while distant metastases continue to be a major cause of treatment failure and compromised survival. The intensification of neoadjuvant therapy through TNT addresses this limitation by achieving early systemic control, significant tumor downstaging, and higher rates of pathological complete response, all without compromising early surgical outcomes compared to LCCRT, as demonstrated in this study. Moreover, the authors report that TNT is associated with a shorter total stoma duration and a lower permanent stoma rate, which are meaningful benefits for patients' quality of life. Recent landmark trials, such as RAPIDO and PRODIGE 23, have provided robust evidence supporting the use of TNT, showing improved pathological complete response, better treatment compliance, and reduced distant metastases compared to LCCRT. This study adds valuable real-world data to the growing body of literature affirming the safety and feasibility of TNT from a surgical perspective. We commend the authors for their contribution and agree that further prospective studies with longer follow-up are warranted to evaluate long-term oncological outcomes. (By Prof Sanaa El Majjaoui and Pr Nabil Ismaili) "
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Jabbar SAA, Choo ALE, Wong NW, Ngu JCY, Teo NZ. Comparing early surgical outcomes between total neoadjuvant therapy and standard long course chemoradiotherapy for rectal cancer. World J Gastrointest Oncol 2025; 17(11): 111250
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"This minireview describes the important role of 0steopontin (OPN)-regulated the phosphatidylinositol 3-kinase (PI3K)/protein kinase ..."
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"This minireview describes the important role of 0steopontin (OPN)-regulated the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) signaling pathway in gastrointestinal tumor proliferation, metastasis, chemoresistance, and immune evasion. Targeting osteopontin-regulated PI3K/AKT signaling pathway with PI3K/AKT inhibitors or OPN neutralizing antibodies may reverse drug resistance and suppress metastasis. Further research should be needed to find combination therapies which have the potential to provide more effective anti-tumor activity towards refractory cancers. "
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Nian H, Bai Y, Wang HY, Yu H, Zhang ZL, Shi RH, Zhang S, Wu YB, Zhou DH, Du QC. Targeting the Osteopontin-regulated PI3K/AKT signaling pathway: A molecular approach to overcome drug resistance and metastasis in gastrointestinal tumors. World J Gastrointest Oncol 2025; 17(11): 109923
19
"I want to congratulate the authors for conducting this excellent study on the impact of PAD in PEP. This study has demonstrated that ..."
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"I want to congratulate the authors for conducting this excellent study on the impact of PAD in PEP. This study has demonstrated that PAD, particularly Type B, has a Significant risk of PEP. This subgroup analysis of PAD is important for advancing efforts to prevent PEP. This study included predominantly older patients, where the prevalence of PAD is higher. Whether the presence of only PAD increases the risk of pancreatitis is still difficult to interpret. As PAD increases the difficulty of CBD cannulation, requiring advanced cannulation techniques which itself may increase the risk of PEP, furthermore indication of ERCP is also analysed in both groups "
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Shu J, Liao YS, Zhang YJ, Zhou WL, Zhang H. Impact of periampullary diverticulum on the incidence of post-endoscopic retrograde cholangiography pancreatitis. World J Gastrointest Endosc 2025; 17(11): 111243
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"The study by Li Lin et al., “Early vs conventional initiation of adjuvant chemotherapy in advanced gastric cancer: A ..."
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"The study by Li Lin et al., “Early vs conventional initiation of adjuvant chemotherapy in advanced gastric cancer: A propensity-matched outcomes study,” addresses a clinically relevant question; however, several issues limit the strength and applicability of its conclusions. First, the analysis does not demonstrate any clear advantage of early versus conventional initiation of adjuvant chemotherapy in terms of either overall survival or disease-free survival. A possible benefit is suggested with respect to the rate of peritoneal recurrence, but this signal is difficult to interpret in the absence of any comparison with currently available intraperitoneal treatment strategies. Moreover, the study does not provide robust selection criteria to clearly identify which patients might be optimal candidates for an earlier initiation of adjuvant therapy. Given the well-known short-term physiological impact of gastrectomy, there is a concrete risk that patients starting chemotherapy very early after surgery may actually receive a suboptimal treatment—most notably through dose reductions—precisely in the first cycles, when dose intensity may be most critical. Finally, the heterogeneity of the adjuvant chemotherapy regimens, which persists even after propensity score matching, further complicates interpretation of the results and limits the ability to draw firm conclusions regarding the true effect of treatment timing per se. "
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Lin L, Zhang P, Wang YY, Cai YF, Wen LB, Chen WP, Xiao YF, Li ZK, Liu GY. Early vs conventional initiation of adjuvant chemotherapy in advanced gastric cancer: A propensity-matched outcomes study. World J Gastroenterol 2025; 31(42): 110069
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