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484 items Read more >>
1
"As an author, I have had a very positive experience with the journal. The publication process was efficient and straightforward, with ..."
[Read more]
"As an author, I have had a very positive experience with the journal. The publication process was efficient and straightforward, with clear guidelines and timely updates from the editors. The peer review process was thorough and constructive, which helped me to improve the quality of my manuscript. The journal's website is user-friendly and easy to navigate, making it convenient for authors to submit their work and track the publication status. Overall, I am very satisfied with the service provided by the journal and would recommend it to other authors. "
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Wu CJ, Liu H, Tu LJ, Hu JY. Peroxisome proliferator-activated receptor gamma mutation in familial partial lipodystrophy type three: A case report and review of literature. World J Diabetes 2024; 15(12): 2360-2369
2
"I am satisfied with the editing and publishing process of the paper. The peer review comments were also very useful and extremely ..."
[Read more]
"I am satisfied with the editing and publishing process of the paper. The peer review comments were also very useful and extremely helpful in improving the quality of this paper. Thank you for your cooperation. I am very grateful. If I get the chance, I would like to submit another paper. "
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Kayano H, Okada KI, Yamamoto S, Koyanagi K. Establishment of a surveillance program for anal cancer in Crohn's disease. World J Gastroenterol 2024; 30(45): 4844-4849
3
"The editors of your journal are very dedicated and responsible, and the peer review suggestions are also very objective and accurate, ..."
[Read more]
"The editors of your journal are very dedicated and responsible, and the peer review suggestions are also very objective and accurate, whether it is the editors or the peer review, they have helped our manuscript to a certain extent, and we are very satisfied with the publication process in your journal, and the submission operating system is also very simple and convenient, which is convenient for the author to reply in a timely manner, and I hope to have the opportunity to publish articles in your journal in the future! "
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Quan Y, Yang XJ. Metabolic syndrome and acute pancreatitis: Current status and future prospects. World J Gastroenterol 2024; 30(45): 4859-4863
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"I am very satisfied with the submission process this time, and the relevant staff are diligent and responsible. The editor can also ..."
[Read more]
"I am very satisfied with the submission process this time, and the relevant staff are diligent and responsible. The editor can also contact us promptly for minor issues in the article, and the entire submission process takes a short time. This magazine is very professional. If given the opportunity, I will resubmit to this magazine. "
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Yin ML, Song HL, Yang Y, Zheng WP, Liu T, Shen ZY. Correction to: Effect of CXCR3/HO-1 genes modified bone marrow mesenchymal stem cells on small bowel transplant rejection. World J Gastroenterol 2024; 30(44): 4768-4770
5
"I am satisfied with article processed performed by the editorial office and peer review's comments, that help me improve my article's ..."
[Read more]
"I am satisfied with article processed performed by the editorial office and peer review's comments, that help me improve my article's quality. I have some comment. Many of e-mails from editor were sent into my junk mails. I think that it might due to the pattern of e-mail address that were rather informal. I suggest that editor should send e-mail to authors by using the formal journal's e-mail address. "
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Teerasarntipan T, Thanapirom K, Chaiteerakij R, Komolmit P, Treeprasertsuk S. Validation of prognostic scores for predicting acute liver failure and in-hospital death in patients with dengue-induced severe hepatitis. World J Gastroenterol 2024; 30(45): 4781-4790
6
"The peer review reports for our manuscript are fair and objective which is great help to our manuscript. The editors clearly have ..."
[Read more]
"The peer review reports for our manuscript are fair and objective which is great help to our manuscript. The editors clearly have a great eye for quality and a commitment to providing readers with a top-notch publication. I highly recommend this magazine to anyone looking for a great read. It's a valuable resource that I always look forward to picking up. "
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Liu J, Song XY, Li XT, Yang M, Wang F, Han Y, Jiang Y, Lei YX, Jiang M, Zhang W, Tang DQ. β-Arrestin-2 enhances endoplasmic reticulum stress-induced glomerular endothelial cell injury by activating transcription factor 6 in diabetic nephropathy. World J Diabetes 2024; 15(12): 2322-2337
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"Thank you very much for the reviewers' serious and responsible review, and thank you for the editor's timely processing of our ..."
[Read more]
"Thank you very much for the reviewers' serious and responsible review, and thank you for the editor's timely processing of our manuscript, we are very satisfied with the publication process of the manuscript, and in the future, we will consider to continue to submit academic results in your journal, and we wish your journal to develop more and more well! "
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Wu ZY, Li H, Chen JL, Su K, Weng ML, Han YW. Nomogram model based on γ-glutamyl transferase to albumin ratio predicts survival in hepatocellular carcinoma patients with transarterial chemoembolization treatment. World J Gastrointest Oncol 2024; 16(12): 4650-4662
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"Good morning, I thought that the review would be easier because it was a case report, I liked that it was very strict in all aspects ..."
[Read more]
"Good morning, I thought that the review would be easier because it was a case report, I liked that it was very strict in all aspects of the article, from the title, its discussion and conclusion, its good comments in the figures and tables very well directed Very happy to be approved, "
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Carrera E, Alvarado J, Astudillo M, Pillajo G. Wilson's disease in two siblings from Ecuador: Two case reports. World J Clin Cases 2025; 13(3): 99558
9
"Thanks very much for your kind work and consideration on publication of our paper. On behalf of my co-authors, we would like to express ..."
[Read more]
"Thanks very much for your kind work and consideration on publication of our paper. On behalf of my co-authors, we would like to express our great appreciation to editor and reviewers. The editors of the World Journal of Gastroenterology are generally very friendly, and the peer review comments are very pertinent. The submission handling time is very fast, and I am very satisfied with the overall submission process. "
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Xu ZL, Qian GX, Li YH, Lu JL, Wei MT, Bu XY, Ge YS, Cheng Y, Jia WD. Evaluating microvascular invasion in hepatitis B virus-related hepatocellular carcinoma based on contrast-enhanced computed tomography radiomics and clinicoradiological factors. World J Gastroenterol 2024; 30(45): 4801-4816
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"As always, excellent handling. The peer review was fair and objective, the overall timeline was according to my expectations. The ..."
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"As always, excellent handling. The peer review was fair and objective, the overall timeline was according to my expectations. The pdfs and online document is easy to read and follow. I have no issues regarding this manuscript processing and publication. However, of late I have observed that there is some issue with F6 submission system and on certain times, the account gets locked/ inactivated which creates unnecessary stress to the authors/ reviewer or even editors. I would urge the submission department to look into it. "
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Dodamani MH, Hatwal J, Batta A. Role of intestinal glucagon-like peptide-1 in impaired counter-regulatory responses to hypoglycemia. World J Diabetes 2024; 15(12): 2394-2398
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"I would like to express my sincere gratitude to the editorial committee of World Journal of Clinical Cases for their professionalism ..."
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"I would like to express my sincere gratitude to the editorial committee of World Journal of Clinical Cases for their professionalism and the high quality of their review and publication process for my scientific article. From the initial submission of the manuscript to the final publication, the editorial team demonstrated a highly efficient approach with clear and timely communication at every stage. The reviewers provided constructive and detailed feedback that significantly enriched the content and clarity of the article, demonstrating a profound understanding of the subject matter. These contributions were essential in improving the quality of my work and ensuring it met the highest academic standards. I am particularly satisfied with the speed of the review process and the committee's willingness to clarify any questions throughout the process. Without a doubt, the publishing experience with World Journal of Clinical Cases has been of great value to my professional development, and I highly recommend this journal to researchers seeking rigorous reviews and fair, collaborative treatment. "
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Lomelí Martínez SM, Martínez Nieto M, Mercado González AE. Tongluo Jiedu as an adjuvant therapy for oral cancer. World J Clin Cases 2025; 13(5): 97909
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"We are immensely satisfied with our online submission platform, which boasts an intuitive and user-friendly interface. Throughout ..."
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"We are immensely satisfied with our online submission platform, which boasts an intuitive and user-friendly interface. Throughout the peer review process, the reviewers delivered comprehensive revision recommendations and directional guidance, thereby enhancing the manuscript's standardization, scientific rigor, and rationality. The ultimate acceptance of the manuscript is inseparable from their diligent efforts. "
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Guo YP, Pokhrel G, Wang YY, Wen Q, Hang G, Chen B. Rethinking the diagnosis and treatment of renal anastomotic hemangioma after partial nephrectomy. World J Clin Cases 2025; 13(5): 98081
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"The journal serves as a vital platform for groundbreaking research, consistently showcasing high-quality articles that significantly ..."
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"The journal serves as a vital platform for groundbreaking research, consistently showcasing high-quality articles that significantly advance the field. Its rigorous peer-review process guarantees the credibility and integrity of published work. Additionally, the journal's commitment to diverse topics fosters interdisciplinary collaboration, encouraging the exchange of ideas across various domains. With its timely publications and emphasis on current trends, it is an indispensable resource for academics and professionals eager to stay informed about the latest developments and enhance their own research pursuits. This journal not only contributes to scholarly discourse but also inspires future innovations. "
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Guo YB, Wu YM, Lin ZZ. Enhancing the radiosensitivity of colorectal cancer cells by reducing spermine synthase through promoting autophagy and DNA damage. World J Gastrointest Oncol 2024; 16(12): 4716-4727
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"We are satisfied with the peer review, the editing quality and publication process of our article. The expert review opinions are ..."
[Read more]
"We are satisfied with the peer review, the editing quality and publication process of our article. The expert review opinions are objective and very helpful in improving the quality of the article. But i think that the time of the peer review is long. I hope the magazine can shorten the review time, so as to ensure that high-quality manuscripts can be published as soon as possible. "
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Dai C, Huang YH, Jiang M. Diagnostic delay in inflammatory bowel disease: Current situation and problems. World J Gastroenterol 2024; 30(44): 4738-4740
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"The submission process for this journal is truly commendable. It is seamlessly designed to provide authors with an intuitive and ..."
[Read more]
"The submission process for this journal is truly commendable. It is seamlessly designed to provide authors with an intuitive and efficient experience from start to finish. The platform is user-friendly, making it easy to navigate through each step, whether uploading manuscripts, filling in metadata, or tracking the status of submissions. The responsiveness of the editorial team is exemplary, with prompt acknowledgment and constructive feedback that fosters a collaborative and supportive environment. Moreover, the clarity in communication guidelines ensures that contributors understand the expectations and requirements, enhancing the overall quality of the content. This journal's commitment to a streamlined, respectful, and efficient submission process sets a high standard in the publishing industry, making it a delight for writers to engage with and contribute to. "
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Zhang C, Ouyang YW, Li ZT. Role of Helicobacter pylori in esophageal carcinogenesis: Friend or foe? World J Gastroenterol 2024; 30(44): 4759-4762
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"I would like to express my sincere appreciation to the editorial team, peer reviewers, and staff of the World Journal of Diabetes ..."
[Read more]
"I would like to express my sincere appreciation to the editorial team, peer reviewers, and staff of the World Journal of Diabetes for their invaluable contributions and professionalism throughout the publication process of my manuscript, "Teneligliptin mitigates diabetic cardiomyopathy through inflammasome inhibition: Insights from experimental studies". The efficient and thorough peer review, combined with insightful feedback, has significantly enhanced the quality of the work. The journal's transparent and well-organized publication process was commendable. I found the online submission system user-friendly and the communication timely at every stage, from submission to final publication. This streamlined experience reflects the dedication of the World Journal of Diabetes team to fostering academic excellence. I particularly value the open-access nature of this journal, which ensures broad visibility and accessibility of the research to the scientific community and beyond. This is critical for advancing discussions and collaborations in the field of diabetes research. Moving forward, I encourage the editorial team to continue prioritizing rigorous peer review and high editorial standards while exploring ways to expedite the review process without compromising quality. Additionally, providing more frequent updates on manuscript status during review stages could further enhance the experience for authors. Overall, I am very satisfied with the process and am honored to contribute to such a reputable journal. Thank you for providing a platform to share our findings and for your commitment to advancing scientific knowledge. "
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Cheng CY, Hao WR, Liu JC, Cheng TH. Teneligliptin mitigates diabetic cardiomyopathy through inflammasome inhibition: Insights from experimental studies. World J Diabetes 2024; 15(12): 2370-2375
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"Focus of the report for the editors seems to be mainly on the quality of the language since a major English revision report is as ..."
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"Focus of the report for the editors seems to be mainly on the quality of the language since a major English revision report is as good as article rejection for authors who cannot afford the charges for language editing. I strongly recommend the journal to dilute the requirements of language editing based on peer review processes, as many a time, the peer reviewers themselves are not particularly proficient in the English language "
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Maheshwari V, Basu S. Prevalence of obesity, determinants, and its association with hyperglycaemia among community dwelling older adolescents in India. World J Clin Pediatr 2024; 13(4): 91638
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"We are pleased to submit our manuscript for consideration in the World Journal of Gastrointestinal Oncology. 1. We spent a lot of ..."
[Read more]
"We are pleased to submit our manuscript for consideration in the World Journal of Gastrointestinal Oncology. 1. We spent a lot of time to seek peer-reviewers and want to solve this problem. 2. When replying to comments, many files need to be uploaded,but now only one could be uploaded. 3.I would like to receive some e-mails introducting the interesting topics of journals. "
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Zhou YC, Wang QQ, Zhou GYJ, Yin TF, Zhao DY, Sun XZ, Tan C, Zhou L, Yao SK. Matrine promotes colorectal cancer apoptosis by downregulating shank-associated RH domain interactor expression. World J Gastrointest Oncol 2024; 16(12): 4700-4715
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"It took about 147 days from submission to final acceptance,and the whole process was very efficient. In general, we are satisfied ..."
[Read more]
"It took about 147 days from submission to final acceptance,and the whole process was very efficient. In general, we are satisfied with the manuscript editing, publishing process and peer review of World Journal of Clinical Cases.We would like to continue prioritizing submission of our new manuscripts to World Journal of Clinical Cases in the future. "
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Li N, Ren YY, Tang Y, Yang Q, Meng TT, Li S, Zhang J. Pulp health and calcific healing of a complicated crown–root fracture with additional root fracture in a maxillary incisor: A case report. World J Clin Cases 2025; 13(3): 98104
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"The entire processing of the manuscript, from submission to publication, was clear and very well conducted by the editorial team and ..."
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"The entire processing of the manuscript, from submission to publication, was clear and very well conducted by the editorial team and reviewers. We are grateful for the opportunity to publish our article in this highly regarded journal in the global scientific community. The reviewers' comments contributed greatly to improving the quality. "
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Paulini MR, Montarele LF, Pitol DL, Giannocco G, Pereira BF, Buchaim DV, Reis CHB, Buchaim RL, Mardegan Issa JP. Gene expression analysis of cytokines and MMPs in melatonin and rhBMP-2 enhanced bone remodeling. World J Orthop 2024; 15(11): 1075-1087
16985 items Read more >>
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"1. Title does not indicate the type of study. The manuscript type (randomised control trial) can be included in the title.
2. What ..."
[Read more]
"1. Title does not indicate the type of study. The manuscript type (randomised control trial) can be included in the title.
2. What were the literacy levels / sugar control / medication dosages before entering the trial?
3. The groups appear heterogeneous in terms of the type of nursing care given. This appears to introduce bias, which is a study limitation.
4. Blinding could have been included"
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Shi H, Liu C, Luo HY. Impact of community public health care on treatment effect, health cognition, and self-management in patients with type 2 diabetes. World J Clin Cases 2025; 13(5): 95183
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"1. Title has a language error. "How often do we think off in clinical practice?" Typographic error 'off' to be corrected
2. "By ..."
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"1. Title has a language error. "How often do we think off in clinical practice?" Typographic error 'off' to be corrected
2. "By addressing the primary conditions causing secondary diabetes, such as excising pituitary adenomas, providing glucocorticoid supplementation, and implementing symptomatic treatments, patients can experience a significant decrease in blood glucose levels" Requires rephrasing to convey the correct meaning.
"
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Reddy KS, Morya AK, Gaur A, Varatharajan S. Importance of etiologies of secondary diabetes: How often do we think off in clinical practice? World J Clin Cases 2025; 13(5): 95879
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"1. Title does not mention the article type. Suggested to include the nature of the manuscript as descriptive review
2. Are the ..."
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"1. Title does not mention the article type. Suggested to include the nature of the manuscript as descriptive review
2. Are the expenditure involved in setting up and training included in the discussion? A short review about the cost / training issues involved can be added
3. Conclusion can be brief with a preceding summary to include the overall sum up."
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Abdalla MMI, Mohanraj J. Revolutionizing diabetic retinopathy screening and management: The role of artificial intelligence and machine learning. World J Clin Cases 2025; 13(5): 101306
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"The work is very interesting and very useful. The introduction is rather short, I would have expanded with some details on the ..."
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"The work is very interesting and very useful. The introduction is rather short, I would have expanded with some details on the prevalence values and geographical distribution. A "Material and Methods" session is missing. Although narrative as a review, it is important to at least declare the keywords used and search engines. The Results are well described and the table is quite clear. I would have added some graphs to clarify the percentages and prevalence of maxillary and mandibular bone lesions in these syndromes. The literature cited is relevant and recent."
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Schuch LF, Silveira FM, Pereira-Prado V, Sicco E, Pandiar D, Villarroel-Dorrego M, Bologna-Molina R. Clinicopathological and molecular insights into odontogenic tumors associated with syndromes: A comprehensive review. World J Exp Med 2024; 14(4): 98005
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"**Review Comments**
This study explores the effects of mesenchymal stem cells (MSCs) and hyaluronic acid (HA) on inflammatory ..."
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"**Review Comments**
This study explores the effects of mesenchymal stem cells (MSCs) and hyaluronic acid (HA) on inflammatory markers and antioxidant defense mechanisms in experimental osteoarthritis (OA). The findings indicate that BMMSCs and HA exhibit significant anti-inflammatory, antioxidative, and anti-arthritic effects in Wistar rats with monosodium iodoacetate (MIA)-induced OA.
While the results highlight the therapeutic potential of BMMSCs and HA in OA management, the study lacks experimental evidence elucidating the specific pathways or mechanisms through which these agents confer their protective effects against MIA-induced OA. Addressing this gap would substantially enhance the scientific depth of the manuscript.
To strengthen the study's impact and provide continuity for future research, I suggest the following:
1. **Investigation of Cellular and Molecular Mechanisms**: Incorporating data on the signaling pathways or molecular mechanisms involved in the protective effects of BMMSCs and HA would be invaluable. For instance, exploring their roles in modulating inflammatory cytokines, oxidative stress pathways, or cartilage regeneration processes could offer greater insight into the underlying biology.
2. **Extension of Experimental Design**: In future experiments, the authors could consider validating their findings with additional assays, such as gene expression profiling, protein analysis, or pathway inhibition studies. This would not only reinforce the study's conclusions but also provide a foundation for potential therapeutic applications of BMMSCs and HA in OA treatment.
By addressing these aspects, the manuscript would offer a more comprehensive understanding of the mechanisms of action and further solidify its contributions to the field of osteoarthritis research."
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Hagag UI, Halfaya FM, Al-Muzafar HM, Al-Jameel SS, Amin KA, Abou El-Kheir W, Mahdi EA, Hassan GANR, Ahmed OM. Impacts of mesenchymal stem cells and hyaluronic acid on inflammatory indicators and antioxidant defense in experimental ankle osteoarthritis. World J Orthop 2024; 15(11): 1056-1074
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"**Review Comments**
This study investigates the effects of local administration of melatonin at various concentrations, either ..."
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"**Review Comments**
This study investigates the effects of local administration of melatonin at various concentrations, either alone or in combination with recombinant human bone morphogenetic protein-2 (rhBMP-2), on enhancing bone regeneration in surgically induced defects. The authors demonstrate that the combination of melatonin (1 μg) with rhBMP-2 (5 μg) exhibits a measurable impact on bone repair in critical-sized cranial defects in rats, primarily through guided bone regeneration mechanisms. The use of animal models to test the proposed hypothesis provides valuable insights into the potential therapeutic applications of melatonin in bone defect repair.
To further enhance the scientific rigor and impact of the manuscript, the following suggestions are offered:
1. **Incorporation of Histological or Cellular and Molecular Biology Evidence**: While the study presents the group differences using statistical graphs, incorporating representative histological images or molecular biology data would significantly enrich the discussion. Such visual evidence would provide a clearer understanding of the mechanisms underlying bone regeneration and validate the experimental findings more robustly.
2. **Elaboration on Mechanistic Insights**: Beyond statistical comparisons, a deeper exploration of the cellular pathways and molecular mechanisms through which melatonin and rhBMP-2 synergistically promote bone healing would elevate the manuscript’s academic value. For instance, highlighting their effects on osteoblast differentiation, angiogenesis, or inflammatory modulation could add a more comprehensive perspective.
By addressing these points, the manuscript could provide a more thorough and impactful contribution to the field of bone defect repair and regenerative medicine."
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Paulini MR, Montarele LF, Pitol DL, Giannocco G, Pereira BF, Buchaim DV, Reis CHB, Buchaim RL, Mardegan Issa JP. Gene expression analysis of cytokines and MMPs in melatonin and rhBMP-2 enhanced bone remodeling. World J Orthop 2024; 15(11): 1075-1087
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"**Review Comments**
This manuscript primarily provides a comprehensive review focusing on the application of adipose-derived ..."
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"**Review Comments**
This manuscript primarily provides a comprehensive review focusing on the application of adipose-derived stem cells (ADSCs) in the treatment of knee osteoarthritis (KOA). The authors effectively highlight the advantages of ADSCs over bone marrow-derived mesenchymal stem cells (BMSCs), such as their higher yield in adipose tissue and ease of extraction. Overall, the manuscript is well-structured, and the inclusion of the abstract figure enhances readability for a broader audience.
However, to further strengthen the manuscript and improve its impact, I recommend the following recommendations:
1. **Detailed Discussion on Molecular Mechanisms**: While the authors present the general advantages of ADSCs, the review would significantly benefit from a more in-depth discussion of the specific molecular mechanisms through which ADSCs exert therapeutic effects in KOA. This could include signaling pathways, cytokine interactions, and their role in cartilage regeneration or inflammation modulation. Providing such details would not only increase the article's scientific rigor but also broaden its appeal to researchers seeking to understand the translational potential of ADSCs.
2. **Addressing Limitations of ADSC Therapy**: The manuscript underrepresents the limitations and challenges associated with ADSC-based treatments for KOA. A more thorough discussion of issues such as potential risks, variability in therapeutic outcomes, regulatory hurdles, and the lack of large-scale clinical validation would enrich the review. Addressing these aspects is crucial, as overcoming these limitations could pave the way for more significant advancements and applications of ADSC therapy in the future.
Incorporating these suggestions will enhance the manuscript's scientific depth and ensure it serves as a valuable resource for researchers and clinicians in the field."
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de Sousa EB, Gabbi Filho JPA, Gameiro VS, Baptista LS. Adipose-derived stem cells and knee osteoarthritis: New perspectives, old concerns. World J Orthop 2024; 15(11): 1001-1006
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"Despite the high quality of the editorial letter with high quality, this is not an original article or clinical randomized clinical ..."
[Read more]
"Despite the high quality of the editorial letter with high quality, this is not an original article or clinical randomized clinical trial that can suggest new therapies or diagnosis strategies for implemmenting in the clinical practise or design new therapies. High quaility on the revision is not enough for getting prize."
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Kheber NN, Nashwan AJ. What is the optimal dialysis method for diabetic patients with end stage kidney disease? World J Diabetes 2024; 15(12): 2272-2275
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"Despite the high quality of the editorial letter with high quality, this is not an original article or clinical randomized clinical ..."
[Read more]
"Despite the high quality of the editorial letter with high quality, this is not an original article or clinical randomized clinical trial that can suggest new therapies or diagnosis strategies for implemmenting in the clinical practise or design new therapies. High quaility on the revision is not enough for getting prize."
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Cheng CY, Hao WR, Liu JC, Cheng TH. Teneligliptin mitigates diabetic cardiomyopathy through inflammasome inhibition: Insights from experimental studies. World J Diabetes 2024; 15(12): 2370-2375
10
"Despite the high quality of the editorial letter with high quality, this is not an original article or clinical randomized clinical ..."
[Read more]
"Despite the high quality of the editorial letter with high quality, this is not an original article or clinical randomized clinical trial that can suggest new therapies or diagnosis strategies for implemmenting in the clinical practise or design new therapies. High quaility on the revision is not enough for getting prize."
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Rao AG, Nashwan AJ. Intersection of the glymphatic system and diabetes: Navigating a new frontier. World J Diabetes 2024; 15(12): 2376-2379
11
"Despite the high quality of the editorial letter with high quality, this is not an original article or clinical randomized clinical ..."
[Read more]
"Despite the high quality of the editorial letter with high quality, this is not an original article or clinical randomized clinical trial that can suggest new therapies or diagnosis strategies for implemmenting in the clinical practise or design new therapies. High quaility on the revision is not enough for getting prize."
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Zhang KX, Kan CX, Wang YQ, Hou NN, Sun XD. Intestinal glucagon-like peptide-1 in hypoglycemic counterregulation for type 1 diabetes management. World J Diabetes 2024; 15(12): 2380-2383
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"Despite the high quality of the editorial letter with high quality, this is not an original article or clinical randomized clinical ..."
[Read more]
"Despite the high quality of the editorial letter with high quality, this is not an original article or clinical randomized clinical trial that can suggest new therapies or diagnosis strategies for implemmenting in the clinical practise or design new therapies. High quaility on the revision is not enough for getting prize."
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Chen LH, Ran XW. Relevance of macrophages in the wound healing process among individuals afflicted with diabetic foot ulcers. World J Diabetes 2024; 15(12): 2384-2386
13
"Despite the high quality of the editorial letter with high quality, this is not an original article or clinical randomized clinical ..."
[Read more]
"Despite the high quality of the editorial letter with high quality, this is not an original article or clinical randomized clinical trial that can suggest new therapies or diagnosis strategies for implemmenting in the clinical practise or design new therapies. High quaility on the revision is not enough for getting prize."
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Cao YH, Zhou YM, Wang SY, Guo J, Cen LS. Promise of the gut microbiota in prevention and traditional Chinese medicine treatment of diabetic peripheral neuropathy. World J Diabetes 2024; 15(12): 2387-2393
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"Despite the high quality of the editorial letter with high quality, this is not an original article or clinical randomized clinical ..."
[Read more]
"Despite the high quality of the editorial letter with high quality, this is not an original article or clinical randomized clinical trial that can suggest new therapies or diagnosis strategies for implemmenting in the clinical practise or design new therapies. High quaility on the revision is not enough for getting prize."
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Dodamani MH, Hatwal J, Batta A. Role of intestinal glucagon-like peptide-1 in impaired counter-regulatory responses to hypoglycemia. World J Diabetes 2024; 15(12): 2394-2398
15
"Despite the high quality of the editorial letter with high quality, this is not an original article or clinical randomized clinical ..."
[Read more]
"Despite the high quality of the editorial letter with high quality, this is not an original article or clinical randomized clinical trial that can suggest new therapies or diagnosis strategies for implemmenting in the clinical practise or design new therapies. High quaility on the revision is not enough for getting prize."
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Yang YJ, Chen XE, Zhou XC, Liang FX. Mesenchymal stem cell-derived extracellular vesicles: A promising therapeutic strategy in diabetic osteoporosis. World J Diabetes 2024; 15(12): 2399-2403
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"Despite the high quality of the editorial letter with high quality, this is not an original article or clinical randomized clinical ..."
[Read more]
"Despite the high quality of the editorial letter with high quality, this is not an original article or clinical randomized clinical trial that can suggest new therapies or diagnosis strategies for implemmenting in the clinical practise or design new therapies. High quaility on the revision is not enough for getting prize."
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Velikova T, Vasilev G. Insights into glymphatic system dysfunction and glucose continuum. World J Diabetes 2024; 15(12): 2404-2408
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"This ia a randomized controlled trial based on 82 participants with an intervention (alpha-lipoic acid and exercise for 15 consecutive ..."
[Read more]
"This ia a randomized controlled trial based on 82 participants with an intervention (alpha-lipoic acid and exercise for 15 consecutive therapeutic days) compared with alpha-lipoic acid group. The results showed benefits of the intervention, improving motility in patients with diabetic polyneuropathy. The study was well designed and the results can change the clinical practise. "
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Novaković-Bursać S, Talić G, Tomić N, Škrbić R, Soldatovic I. Effect of three-week exercise program on muscle strength and joint mobility in patients with diabetic polyneuropathy: Randomized controlled trial. World J Diabetes 2024; 15(12): 2311-2321
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"This is a prospective study with a huge population (474 participants) in the "deep learning model" system for scoring with and without ..."
[Read more]
"This is a prospective study with a huge population (474 participants) in the "deep learning model" system for scoring with and without diabetic retinopathy and determine a predictor model, based on intelligence artifitial applications on funds photography. This new tool will be useful as future and rapid diagnosis strategy. Artifitial intelligence is a new tool that will improve the fast diagnosis and prediction of diseases. "
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Yao L, Cao CY, Yu GX, Shu XP, Fan XN, Zhang YF. Screening and evaluation of diabetic retinopathy via a deep learning network model: A prospective study. World J Diabetes 2024; 15(12): 2302-2310
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"This preclinical study has used several preclinical models, using animals, cells, and different technologies to demonstrate a ..."
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"This preclinical study has used several preclinical models, using animals, cells, and different technologies to demonstrate a mechanistic pathway of diabetic nephropathy related to reticulum stress, b-arrestin role, and ATF6. Different methods validated the results and were well discussed by the authors. These results might suggest a new therapeutic target for diabetic nephropathy. "
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Liu J, Song XY, Li XT, Yang M, Wang F, Han Y, Jiang Y, Lei YX, Jiang M, Zhang W, Tang DQ. β-Arrestin-2 enhances endoplasmic reticulum stress-induced glomerular endothelial cell injury by activating transcription factor 6 in diabetic nephropathy. World J Diabetes 2024; 15(12): 2322-2337
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"The editorial complements well the discussed article Lee et al. "Gut microbiota participates and remodels host metabolism: From ..."
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"The editorial complements well the discussed article Lee et al. "Gut microbiota participates and remodels host metabolism: From treating patients to treating their gut flora". The material presented shows how little we know about the microbiome and its relationship with the host. The possibility of developing new drugs by unravelling the mechanisms of the microbiome-host relationship is discussed."
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Han S, Li RH, Gao P. Gut microbiota participates and remodels host metabolism: From treating patients to treating their gut flora. World J Gastroenterol 2024; 30(45): 4839-4843
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Peer-Reviewers and Manuscript Statistics
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- Total peer-reviewers
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"This article presents a case report of air embolism occurring during endoscopic retrograde cholangiopancreatography (ERCP), ..."
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"This article presents a case report of air embolism occurring during endoscopic retrograde cholangiopancreatography (ERCP), emphasizing the necessity for gastroenterologists to maintain a high level of vigilance regarding this potential complication during such procedures. While ERCP is a widely used and effective diagnostic and therapeutic technique, air embolism represents a serious complication that can significantly jeopardize patient health. Consequently, this article not only reviews pertinent cases and analyzes the mechanisms, clinical manifestations, and countermeasures associated with air embolism but also underscores the importance of preventive measures that medical staff should implement to minimize the incidence of such complications during ERCP. The aim of this article is to provide a comprehensive overview of relevant knowledge, thereby enabling medical professionals to better understand and address this issue, ultimately enhancing the safety and effectiveness of clinical operations. "
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Li JH, Luo ZK, Zhang Y, Lu TT, Deng Y, Shu RT, Yu H. Systemic air embolism associated with endoscopic retrograde cholangiopancreatography: A case report. World J Gastrointest Endosc 2024; 16(11): 617-622
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"Exercise during pregnancy improve organ development in offspring with gestational diabetes mellitus Shengju Chen, Hangming Fan, Yu ..."
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"Exercise during pregnancy improve organ development in offspring with gestational diabetes mellitus Shengju Chen, Hangming Fan, Yu Chen Abstract In this commentary, we discuss the study by Tang et al., “Effect of exercise during pregnancy on offspring development through ameliorating high glucose and hypoxia in gestational diabetes mellitus”. Gestational diabetes mellitus (GDM), defined as ‘glucose intolerance with onset or first recognition during pregnancy’, impacts millions of women worldwide and poses significant health risks. Exercise during pregnancy has been shown to improve offspring health outcomes in obese mothers, potentially reducing epigenetic changes associated with maternal high-fat diets and minimizing abnormalities in lipid and glucose metabolism. However, while prenatal exercise’s impact on metabolic disorders in GDM offspring has been explored, its effects on organ growth remain insufficiently understood. Tang et al. identified GLUT1 and HIF1 as key regulators influencing the development of the heart, liver, and kidney in GDM offspring. Their study demonstrates that exercise during pregnancy supports organ development by inhibiting placental GLUT1 and HIF1 expression in GDM. This work contributes to understanding the role of GLUT1 and HIF1 in moderating the effects of prenatal exercise on organ development in GDM-affected offspring, supporting the idea that maternal exercise is an important intervention for improving offspring outcomes in GDM pregnancies and warrants further investigation in future epigenetic research. Introduction Gestational diabetes mellitus (GDM) is one of the most common pregnancy complications, affecting approximately 20.9 million pregnant women and their newborns worldwide as of 2020. GDM is associated with a range of adverse pregnancy outcomes, including preeclampsia, polyhydramnios, and fetal organomegaly (Pettitt et al., 1980). Additionally, GDM poses several short-term risks to offspring, such as neonatal respiratory distress, metabolic complications (Ferrara et al., 2007), and increased perinatal mortality rates. The GDM quintet management model recommends five core interventions to mitigate these risks, exercise, dietary regulation, maternal education, pharmacological treatment, and fetal health evaluation (Association, 2003). Pathophysiologically, GDM is characterized by hyperglycemia, glucose intolerance, and insulin resistance, typically manifesting in the late second to early third trimester of pregnancy (Buchanan et al., 2012, Jovanovic and Pettitt, 2001, Pereira et al., 2015). Several mechanisms have been proposed to explain these outcomes, including chronic fetal hyperinsulinemia, impaired oxygenation due to elevated metabolic rates, and metabolic acidosis (Freinkel, 1980). In this commentary, we discuss the article by Tang et al., recently published in the recent issue of the World Journal of Diabetes, which explores the impact of maternal exercise during pregnancy on organ development in offspring of mothers with GDM. Risks and complications associated with GDM In a healthy pregnancy, insulin sensitivity decreases to allow more glucose availability for the fetus; however, normoglycemia is typically maintained through increased insulin production by pancreatic β-cells. In cases of GDM, the pancreas may fail to produce sufficient insulin, resulting in elevated blood glucose levels and the onset of GDM (Freinkel, 1980). GDM pregnancies can lead to additional complications that negatively impact maternal and fetal health (Poston et al., 2011). Immediate complications in offspring of overweight women with GDM include macrosomia, the most severe of which is shoulder dystocia; other neonatal complications such as hypoglycemia and hyperbilirubinemia have also been reported (Kaaja and Rönnemaa, 2008, Lecomte et al., 2017). Long-term exposure to GDM increases the risk of obesity, type 2 diabetes, and cardiovascular diseases (CVD) as offspring age (Capobianco et al., 2016). Epigenetic studies indicate that the intrauterine environment significantly influences offspring organ development, and exposure to elevated maternal blood levels can impair fetal health. Maintaining a healthy uterine environment is thus essential to promoting favorable health outcomes in offspring. Exercise, as a non-pharmacological intervention without side effects, is widely used in diabetes prevention and management. Given that pregnancy is a period when non-pharmacological interventions are especially favored by medical staff and patients, exercise is particularly promising for managing GDM. Benefits of exercise during pregnancy Eight national guidelines on exercise during pregnancy recommend 60-150 minutes of aerobic exercise per week for healthy pregnant women (Savvaki et al., 2018). The benefits of exercise for pregnant women include improved overall health, better weight management, reduced risk of GDM and gestational hypertension (Davenport et al., 2018, Yu et al., 2018). For women with GDM, moderate aerobic or combined exercise has been shown to enhance postprandial blood glucose control (Walter and Klaus, 2014), although the optimal duration and intensity remain unclear. Moderate exercise during pregnancy can improve maternal insulin sensitivity, reduce placental lipid accumulation in both male and female fetuses, and alleviate hypoxia, positively influencing the intrauterine environment and fetal growth (Laker et al., 2014). Exercise during pregnancy also promotes healthier liver glucose production, helps maintain liver triglycerides levels, and prevents the expression of liver enzymes and genes in offspring caused by maternal high-fat diet, thereby improving the offspring’s metabolic profile. These findings suggest that maternal exercise can mitigate modifications linked to a high-fat diet, protecting offspring from future metabolic diseases. Regulation of GLUT1 by maternal exercise and offspring health outcomes in GDM The placenta is responsible for transporting essential nutrients and oxygen from maternal to fetal circulation, as fetal gluconeogenesis is minimal (Kalhan and Parimi, 2000). GDM disrupts placental function, leading to various morphological (Treesh and Khair, 2015) and vascular changes (Aldahmash et al., 2022, El Sawy et al., 2018) and including fetal vascular changes and DNA methylation (Song et al., 2022). Placental transport proteins, such as glucose transporters, facilitate nutrient transfer from the mother to the fetus. Glucose is the primary energy source for both placental and fetal growth (Stanirowski et al., 2017), with GLUT1 and GLUT3 serving as the main placental glucose transport proteins in humans. GLUT1 is expressed in syncytiotrophoblast microvilli and the basal membrane, as well as in vascular endothelium and cell layers (Brown et al., 2011, Jansson et al., 1993). Research on GDM in humans and mice shows increased placental GLUT1 expression, likely due to increased glucose availability in maternal circulation, which enhances placental glucose consumption (Muralimanoharan et al., 2016). This increase in GLUT1 may contribute to the higher rates of macrosomia observed in GDM pregnancies (Stanirowski et al., 2022). Moreover, GDM leads to placental hypoxia, elevated hypoxia-inducible (HIF) levels, and glial cell missing 1 degradation, inhibiting trophoblast migration and invasion. Exercise during pregnancy can significantly reduce placental GLUT1 expression and alleviate hypoxia. Silencing GLUT1 can partially counteract the reduced trophoblast migration caused by hyperglycemia and hypoxia. Beyond energy metabolism, GLUT1 is also related to the development of the heart, liver, and kidneys. Zhang et al. investigated the relationship between GLUT1 expression in these organs and their structural and pathological changes, examining how exercise influences growth and development in offspring with GDM. In a neonatal GLUT1 transgenic heart model, increased glucose metabolism can stimulate hyperplastic growth after cardiac injury (Fajardo et al., 2021). Maternal exercise during pregnancy has been shown to lower hepatic GLUT1 expression, reduce inflammatory infiltration, and decrease the risk of liver disease in adult offspring (Baker and Friedman, 2018). In the kidney, GLUT1 functions vary by cell type; elevated GLUT1 in mesangial cells can impair kidney structure, while in podocytes, it may reduce mesangial expansion and fibronectin accumulation (Chen et al., 2024). Future research is recommended to clarify the specific mechanisms by which exercise benefits renal structure and function in GDM offspring. Directions for future studies The specific mechanisms by which maternal exercise during pregnancy improves health outcomes in diabetic offspring remain under investigation, with multiple synergistic pathways likely involved. Given its role in glucose metabolism, GLUT1 is of particular interest as a regulatory factor in mitigating adverse outcomes in offspring of mothers with GDM through exercise. This underscores the significant influence of exercise on glucose metabolism, which enhances the intrauterine environment and supports offspring health. Improved placental GLUT1 expression appears to regulate the GLUT1 levels in offspring organs, positively impacting organ development. These findings extend our understanding of exercise-related epigenetics modifications, yet further research is essential to clarify the pathways through which maternal exercise regulates placental GLUT1, thereby promoting healthy organ development in offspring and underscoring the benefits of prenatal exercise. Conclusion GDM can lead to adverse outcomes for both the mother and their offspring. Maternal exercise during pregnancy improves the intrauterine environment and enhances offspring health. Elevated maternal blood glucose can cause fetal hyperinsulinemia, hypoxia, and metabolic acidosis. Exercise enhances glucose metabolism, reduces high blood sugar levels, and supports a healthier intrauterine environment, thereby decreasing the risk of metabolic diseases in offspring. The study by Tang et al. confirms the association between elevated placental GLUT1 expression in GDM and abnormal offspring organ development related to hypoxia. Their research demonstrates that exercise during pregnancy can improve placental glucose transport and reduce hypoxia, mitigating adverse developmental outcomes in offspring organs at various stages. These findings validate, across human, animal, and cellular models, the molecular mechanisms through which maternal exercise enhances organ development in offspring affected by GDM. This contributes to clinical application and emphasizes the role of epigenetics in promoting offspring health. As research in epigenetic progresses, the pathways through exercise benefits GDM-affected offspring will become clearer, with GLUT1 as a central regulator of glucose metabolism. Further investigation into these mechanisms will advance our understanding of how maternal exercise supports healthier outcomes for GDM offspring. Aldahmash, W.M., Alwasel, S.H., Aljerian, K., 2022. Gestational diabetes mellitus induces placental vasculopathies. Environ Sci Pollut Res Int 29 (13), 19860-19868. Association, A.D., 2003. Gestational diabetes mellitus. Diabetes Care 26 Suppl 1, S103-105. Baker, P.R., 2nd, Friedman, J.E., 2018. Mitochondrial role in the neonatal predisposition to developing nonalcoholic fatty liver disease. J Clin Invest 128 (9), 3692-3703. Brown, K., Heller, D.S., Zamudio, S., Illsley, N.P., 2011. Glucose transporter 3 (GLUT3) protein expression in human placenta across gestation. Placenta 32 (12), 1041-1049. Buchanan, T.A., Xiang, A.H., Page, K.A., 2012. Gestational diabetes mellitus: risks and management during and after pregnancy. Nat Rev Endocrinol 8 (11), 639-649. Capobianco, E., Fornes, D., Linenberg, I., Powell, T.L., Jansson, T., Jawerbaum, A., 2016. A novel rat model of gestational diabetes induced by intrauterine programming is associated with alterations in placental signaling and fetal overgrowth. Mol Cell Endocrinol 422, 221-232. Chen, Y., Bai, X., Chen, J., Huang, M., Hong, Q., Ouyang, Q., Sun, X., Zhang, Y., Liu, J., Wang, X., Wu, L., Chen, X., 2024. Pyruvate kinase M2 regulates kidney fibrosis through pericyte glycolysis during the progression from acute kidney injury to chronic kidney disease. Cell Prolif 57 (2), e13548. Davenport, M.H., Ruchat, S.M., Poitras, V.J., Jaramillo Garcia, A., Gray, C.E., Barrowman, N., Skow, R.J., Meah, V.L., Riske, L., Sobierajski, F., James, M., Kathol, A.J., Nuspl, M., Marchand, A.A., Nagpal, T.S., Slater, L.G., Weeks, A., Adamo, K.B., Davies, G.A., Barakat, R., Mottola, M.F., 2018. Prenatal exercise for the prevention of gestational diabetes mellitus and hypertensive disorders of pregnancy: a systematic review and meta-analysis. Br J Sports Med 52 (21), 1367-1375. El Sawy, N.A., Iqbal, M.S., Alkushi, A.G., EL Sawy, N., Iqbal, M., Alkushi, A., 2018. Histomorphological study of placenta in gestational diabetes mellitus. Int. J. Morphol 36 (2), 687-692. Fajardo, V.M., Feng, I., Chen, B.Y., Perez-Ramirez, C.A., Shi, B., Clark, P., Tian, R., Lien, C.L., Pellegrini, M., Christofk, H., Nakano, H., Nakano, A., 2021. GLUT1 overexpression enhances glucose metabolism and promotes neonatal heart regeneration. Sci Rep 11 (1), 8669. Ferrara, A., Weiss, N.S., Hedderson, M.M., Quesenberry, C.P., Jr., Selby, J.V., Ergas, I.J., Peng, T., Escobar, G.J., Pettitt, D.J., Sacks, D.A., 2007. Pregnancy plasma glucose levels exceeding the American Diabetes Association thresholds, but below the National Diabetes Data Group thresholds for gestational diabetes mellitus, are related to the risk of neonatal macrosomia, hypoglycaemia and hyperbilirubinaemia. Diabetologia 50 (2), 298-306. Freinkel, N., 1980. Banting Lecture 1980. Of pregnancy and progeny. Diabetes 29 (12), 1023-1035. Jansson, T., Wennergren, M., Illsley, N.P., 1993. Glucose transporter protein expression in human placenta throughout gestation and in intrauterine growth retardation. J Clin Endocrinol Metab 77 (6), 1554-1562. Jovanovic, L., Pettitt, D.J., 2001. Gestational diabetes mellitus. Jama 286 (20), 2516-2518. Kaaja, R., Rönnemaa, T., 2008. Gestational diabetes: pathogenesis and consequences to mother and offspring. Rev Diabet Stud 5 (4), 194-202. Kalhan, S., Parimi, P., 2000. Gluconeogenesis in the fetus and neonate. Semin Perinatol 24 (2), 94-106. Laker, R.C., Lillard, T.S., Okutsu, M., Zhang, M., Hoehn, K.L., Connelly, J.J., Yan, Z., 2014. Exercise prevents maternal high-fat diet-induced hypermethylation of the Pgc-1α gene and age-dependent metabolic dysfunction in the offspring. Diabetes 63 (5), 1605-1611. Lecomte, V., Maloney, C.A., Wang, K.W., Morris, M.J., 2017. Effects of paternal obesity on growth and adiposity of male rat offspring. Am J Physiol Endocrinol Metab 312 (2), E117-e125. Muralimanoharan, S., Maloyan, A., Myatt, L., 2016. Mitochondrial function and glucose metabolism in the placenta with gestational diabetes mellitus: role of miR-143. Clin Sci (Lond) 130 (11), 931-941. Pereira, T.J., Moyce, B.L., Kereliuk, S.M., Dolinsky, V.W., 2015. Influence of maternal overnutrition and gestational diabetes on the programming of metabolic health outcomes in the offspring: experimental evidence. Biochem Cell Biol 93 (5), 438-451. Pettitt, D.J., Knowler, W.C., Baird, H.R., Bennett, P.H., 1980. Gestational diabetes: infant and maternal complications of pregnancy in relation to third-trimester glucose tolerance in the Pima Indians. Diabetes Care 3 (3), 458-464. Poston, L., Harthoorn, L.F., Van Der Beek, E.M., 2011. Obesity in pregnancy: implications for the mother and lifelong health of the child. A consensus statement. Pediatr Res 69 (2), 175-180. Savvaki, D., Taousani, E., Goulis, D.G., Tsirou, E., Voziki, E., Douda, H., Nikolettos, N., Tokmakidis, S.P., 2018. Guidelines for exercise during normal pregnancy and gestational diabetes: a review of international recommendations. Hormones (Athens) 17 (4), 521-529. Song, J.Y., Lee, K.E., Byeon, E.J., Choi, J., Kim, S.J., Shin, J.E., 2022. Maternal Gestational Diabetes Influences DNA Methylation in the Serotonin System in the Human Placenta. Life (Basel) 12 (11). Stanirowski, P.J., Szukiewicz, D., Majewska, A., Wątroba, M., Pyzlak, M., Bomba-Opoń, D., Wielgoś, M., 2022. Placental expression of glucose transporters GLUT-1, GLUT-3, GLUT-8 and GLUT-12 in pregnancies complicated by gestational and type 1 diabetes mellitus. J Diabetes Investig 13 (3), 560-570. Stanirowski, P.J., Szukiewicz, D., Pyzlak, M., Abdalla, N., Sawicki, W., Cendrowski, K., 2017. Impact of pre-gestational and gestational diabetes mellitus on the expression of glucose transporters GLUT-1, GLUT-4 and GLUT-9 in human term placenta. Endocrine 55 (3), 799-808. Treesh, S.A., Khair, N.S.B., 2015. Histological Changes of the Human Placenta in Pregnancies Complicated with Diabetes. Journal of Cytology and Histology 6, 1-7. Walter, I., Klaus, S., 2014. Maternal high-fat diet consumption impairs exercise performance in offspring. J Nutr Sci 3, e61. Yu, Y., Xie, R., Shen, C., Shu, L., 2018. Effect of exercise during pregnancy to prevent gestational diabetes mellitus: a systematic review and meta-analysis. J Matern Fetal Neonatal Med 31 (12), 1632-1637. "
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Tang YB, Wang LS, Wu YH, Zhang LX, Hu LY, Wu Q, Zhou ML, Liang ZX. Effect of exercise during pregnancy on offspring development through ameliorating high glucose and hypoxia in gestational diabetes mellitus. World J Diabetes 2024; 15(11): 2203-2219
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"I would love to congratulate the authors for writing this excellent editorial about malignant gastric outlet obstruction. The authors ..."
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"I would love to congratulate the authors for writing this excellent editorial about malignant gastric outlet obstruction. The authors have given an overview of the changing spectrum of therapeutic modalities from surgery to endoscopic stenting to the latest EUS-guided interventions. There was an enlightening discussion about the potential benefit of stomach-partitioning gastrojejunostomy to reduce the rate of delayed gastric emptying. The authors have rightly advocated the need for a holistic approach to treat patients with malignant gastric outlet obstructions, keeping in mind their nutritional and clinical status. "
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Jiang L, Chen XP. Treatment of choice for malignant gastric outlet obstruction: More than clearing the road. World J Gastrointest Endosc 2024; 16(11): 587-594
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"I would like to congratulate the authors for reporting a rare but potentially treatable complication of ERCP. The authors have clearly ..."
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"I would like to congratulate the authors for reporting a rare but potentially treatable complication of ERCP. The authors have clearly stated the scenarios when air embolism should be suspected in a patient undergoing ERCP. The authors have beautifully shown the relevant images showing air embolism. They have also discussed in detail about the timing and efficacy of hyperbaric oxygen therapy for such patients. As GI endoscopists doing regular ERCP, we should be aware of all the potential complications of ERCP, their manifestations, how to diagnose them early and the readily available treatment modalities and availability. "
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Li JH, Luo ZK, Zhang Y, Lu TT, Deng Y, Shu RT, Yu H. Systemic air embolism associated with endoscopic retrograde cholangiopancreatography: A case report. World J Gastrointest Endosc 2024; 16(11): 617-622
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"Re-evaluating the clinical impact of functional regulatory variants Ying Ming, Yun-Ling Du, Meng-Na Zhang Ying Ming, Molecular ..."
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"Re-evaluating the clinical impact of functional regulatory variants Ying Ming, Yun-Ling Du, Meng-Na Zhang Ying Ming, Molecular Diagnosis Center,The Affiliated Hospital of Chengde Medical University, Chengde, 067000, China Yun-Ling Du, Molecular Diagnosis Center,The Affiliated Hospital of Chengde Medical University, Chengde, 067000, China Meng-Na Zhang, Molecular Diagnosis Center,The Affiliated Hospital of Chengde Medical University, Chengde, 067000, China Meng-Na Zhang, Hebei Key Laboratory of Panvascular Diseases, Chengde, 067000, China ORCID number: Ying Ming (0009-0006-2161-8207) , Yun-Ling Du (0000-0001-7624-3226) , Meng-Na Zhang (0000-0001-7624-3226) Author contributions: Ying Ming contributed to the initial drafting of the work; Yun-Ling Du contributed to the drafting process; Meng-Na Zhang contributed to the initial drafting and provided overall supervision to the drafting process; All authors have read and approved the final version of the manuscript. Conflict-of-interest statement: The authors declare that they have no conflict of interest. Corresponding author: Meng-Na Zhang, Molecular Diagnosis Center,The Affiliated Hospital of Chengde Medical University, Chengde, China zhangmengna2014@sina.com Abstract Serotonin 1A receptor polymorphism (5-HTR1A) C-1019G polymorphism (rs6295) is a functional regulatory variants reported to be related with multiple phenotypes including major depression, suicidal behavior and antidepressant response. However, clinical studies investigating this variant and its potential phenotypes had incongruous findings. Molecular studies on this variant showed it does regulate HTR1A expression but meta-analysis showed it had negative relationship with antidepressant drug response in major depressive disorder (MDD), as reported by Wu et al. in the lasted issue of the World Journal of Psychiatry. This suggested the importance of re-evaluating the clinical impact of functional regulatory variants. Key words: regulatory variants, snp-meta, snp-phenotype association Core Tip: Functional regulatory variants might have negative relationship with putative phenotypes even it do regulate gene expression. Single nucleotide polymorphism (SNP) meta analysis helps to identify a more robust SNP-phenotype relationship. We carefully read the article titled “Association between 5-HTR1A gene C-1019G polymorphism and antidepressant response in patients with major depressive disorder: A meta-analysis” published in the World Journal of Psychiatry by Wu et al.[1]. In this study the authors reviewed 11 clinical studies about serotonin 1A receptor polymorphism (5-HTR1A) C-1019G polymorphism (rs6295) and antidepressant response. Though reported to be related with major depression[2], suicidal behavior[3] and antidepressant response[4], rs6295 did not show significant association with antidepressant drug response in major depressive disorder (MDD) in this meta-analysis. Genome-wide association studies (GWAS) show to be a useful tool to investigate the effect of polymorphism on clinical phenotypes. Most disease-associated variants are non-coding variants. Researchers have developed multiple methods to identify functional regulatory variants from putative regulatory regions and their cis-regulated genes, like massively parallel reporter assays (MPRAs) and expression quantitative trait loci (eQTL)[5,6]. The 5-HTR1A C-1019G polymorphism (rs6295) reviewed by Wu et al. [1] is a functional upstream variant that affects HTR1A expression but not associates with antidepressant response in patients with MDD, though the 5-HT1A receptor is a primary target for most antidepressant drugs. This variant has been reported to influence HTR1A expression in numerous molecular studies. The C-allele of this variant is capable of interacting with transcription factors (TFs) such as Hes1, Hes5, and Deaf1, whereas the G-allele fails to bind these TFs [7]. Although these three TFs are typically regarded as repressors, the activity of Deaf1 at the 5-HT1A promoter exhibits opposing effects in presynaptic versus postsynaptic neuronal cells [7]. In the human prefrontal cortex, the G-allele demonstrates a lower expression level compared to the C-allele; however, this pattern does not hold true for the midbrain and hippocampus [8]. In a humanized mouse model, subjects with GG genotype exhibited higher levels of HTR1A mRNA and protein than those with CC genotype in a line-dependent manner [9]. Furthermore, in 5-HT1A-expressing neuronal cells, the G-allele was found to downregulate 5-HT1A expression [10]. These showed the complexity of regulatory variant function. Clinical researches on rs6295 had incongruous findings, raising the need for a SNP-based meta analysis. A single variant approach is a classical method to ascertain the relationship between a variant and putative phenotypes. Selective serotonin re-uptake Inhibitors (SSRIs) like fluoxetine, paroxetine, sertraline, citalopram, and fluvoxamine were included in this meta analysis, however, the result showed no significant correlation between this variation and antidepressant drug efficacy in MDD in the dominant model (CG vs CC), recessive model (GG vs CC), and combined dominant model (CG+GG vs CC). The 11 clinical studies collected in their meta analysis included multiple populations from over 10 countries with low to moderate heterogeneity and were scored 7-9 according to the Newcastle-Ottawa Scale (NOS), suggesting a result with higher confidence. The negative correlation might due to gene-gene interactions or gene-environment interactions in MDD and its treatment. A genome-wide linkage analysis for MDD showed that association of LHPP SNPs to MDD were depended on HTR1A -1019G allele [11]. Single variant approaches are limited by lower statistical detection power because most phenotypes result from the influence of many genetic variants in many genes and pathways[12]. This limitation is particularly pronounced in pharmacogenetics and multigenic diseases like MDD. Large-scale meta-analysis of GWAS might overcome this disadvantage. However, phenotype analysis involving rs6295 through GWAS is inherently limited due to its ambiguous nature (C/G). It is challenging to distinguish which complementary allele serves as the effect allele. Furthermore, the minor allele frequency (MAF) of rs6295 is G=0.483 in gnomAD and C=0.458 in 1000G, making it impossible to solve the problem by allele frequency. Ambiguous SNPs with allele frequencies close to 0.5 are usually removed in GWAS [13]. Therefore, a SNP meta-analysis remains a viable option for investigating rs6295. The clinical impacts of regulatory variants in monogenic Mendelian diseases have also been noticed. Many bioinformatic tools were developed to predict TF binding of regulatory variants like SNEEP [14]. Many of them use eQTL datasets as training and validation sets. In rs6295’s case, the variant had different functions in different brain regions, and showed negative significance to putative related phenotype. This suggested a limitation of using these tools to predict clinical candidate variants. However, there are few clinical curated regulatory variants databases available. There are only hundreds of regulatory variants in Clinvar database classified as pathogenic/likely pathogenic/benign/likely benign (data not shown). That’s not enough to feed a complex model. Overall, the negative relationship between the functional regulatory variant rs6295 and antidepressant response underscores the importance of re-evaluating the clinical significance of functional regulatory variants. Both positive and negative meta-analyses are essential for establishing robust relationships between polymorphisms and phenotypes. References [1] Wu HN, Zhu SY, Zhang LN, Shen BH, Xu LL. Association between 5-HTR1A gene C-1019G polymorphism and antidepressant response in patients with major depressive disorder: A meta-analysis. World J Psychiatry 2024; 14(10): 1573-1582 [2]Lemonde S, Turecki G, Bakish D, Du L, Hrdina PD, Bown CD, Sequeira A, Kushwaha N, Morris SJ, Basak A, Ou XM, Albert PR. Impaired repression at a 5-hydroxytryptamine 1A receptor gene polymorphism associated with major depression and suicide. J Neurosci. 2003 Sep 24;23(25):8788-99 [3]Hernández-Díaz, Y., Tovilla-Zárate, C. A., Castillo-Avila, R. G., Juárez-Rojop, I. E., Genis-Mendoza, A. D., López-Narváez, M. L., Villar-Juárez, G. E., & González-Castro, T. B. (2023). Association between the HTR1A rs6295 gene polymorphism and suicidal behavior: an updated meta-analysis. European archives of psychiatry and clinical neuroscience, 273(1), 5–14 [4]Lemonde S, Du L, Bakish D, Hrdina P, Albert PR. Association of the C(-1019)G 5-HT1A functional promoter polymorphism with antidepressant response. Int J Neuropsychopharmacol. 2004 Dec;7(4):501-6 [5]Abell NS, DeGorter MK, Gloudemans MJ, Greenwald E, Smith KS, He Z, Montgomery SB. Multiple causal variants underlie genetic associations in humans. Science. 2022 Mar 18;375(6586):1247-1254 [6]Umans BD, Battle A, Gilad Y. Where Are the Disease-Associated eQTLs? Trends Genet. 2021 Feb;37(2):109-124 [7]Czesak M, Lemonde S, Peterson EA, Rogaeva A, Albert PR. Cell-specific repressor or enhancer activities of Deaf-1 at a serotonin 1A receptor gene polymorphism. J Neurosci. 2006 Feb 8;26(6):1864-71 [8]Donaldson ZR, le Francois B, Santos TL, Almli LM, Boldrini M, Champagne FA, Arango V, Mann JJ, Stockmeier CA, Galfalvy H, Albert PR, Ressler KJ, Hen R. The functional serotonin 1a receptor promoter polymorphism, rs6295, is associated with psychiatric illness and differences in transcription. Transl Psychiatry. 2016 Mar 1;6(3):e746 [9]Cunningham AM, Santos TL, Gutzeit VA, Hamilton H, Hen R, Donaldson ZR. Functional Interrogation of a Depression-Related Serotonergic Single Nucleotide Polymorphism, rs6295, Using a Humanized Mouse Model. ACS Chem Neurosci. 2019 Jul 17;10(7):3197-3206 [10]Czesak M, Lemonde S, Peterson EA, Rogaeva A, Albert PR. Cell-specific repressor or enhancer activities of Deaf-1 at a serotonin 1A receptor gene polymorphism. J Neurosci. 2006 Feb 8;26(6):1864-71 [11]Neff CD, Abkevich V, Packer JC, Chen Y, Potter J, Riley R, Davenport C, DeGrado Warren J, Jammulapati S, Bhathena A, Choi WS, Kroeger PE, Metzger RE, Gutin A, Skolnick MH, Shattuck D, Katz DA. Evidence for HTR1A and LHPP as interacting genetic risk factors in major depression. Mol Psychiatry. 2009 Jun;14(6):621-30 [12]Defo J, Awany D, Ramesar R. From SNP to pathway-based GWAS meta-analysis: do current meta-analysis approaches resolve power and replication in genetic association studies? Brief Bioinform. 2023 Jan 19;24(1):bbac600 [13]Ndong Sima, C.A.A., Step, K., Swart, Y. et al. Methodologies underpinning polygenic risk scores estimation: a comprehensive overview. Hum. Genet. 143, 1265–1280 (2024) [14]Baumgarten N, Rumpf L, Kessler T, Schulz MH. A statistical approach for identifying single nucleotide variants that affect transcription factor binding. iScience. 2024 Apr 18;27(5):109765 "
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Wu HN, Zhu SY, Zhang LN, Shen BH, Xu LL. Association between 5-HTR1A gene C-1019G polymorphism and antidepressant response in patients with major depressive disorder: A meta-analysis. World J Psychiatry 2024; 14(10): 1573-1582
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"This study provides valuable insights into the treatment of Helicobacter pylori infection. The comparison between low - dose and ..."
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"This study provides valuable insights into the treatment of Helicobacter pylori infection. The comparison between low - dose and standard - dose tetracycline in combination with amoxicillin quadruple therapy is well - designed and the results are significant.The research is comprehensive, considering factors such as eradication rates and adverse events. It offers a potential alternative treatment option with better safety profiles, which is beneficial for patients. Also, there still exist some questions to be considered. 1. Regarding the article structure • When introducing the research background, various antibiotic resistance rates against Helicobacter pylori are listed in detail. However, could this part be presented more concisely and focused more on the resistance situations of tetracycline and amoxicillin directly related to this study? • In the research methods section, could the description of the patient inclusion and exclusion criteria be more focused on the key points and avoid being interfered by too many irrelevant details? For example, the emphasis could be placed on those factors that may have a crucial impact on the research results. • In the results presentation part, could the comparison results of different groups be shown in a clearer structure? For example, the main results of all groups could be presented first, and then the situations of each subgroup (such as the primary treatment group and the rescue treatment group) could be elaborated in detail respectively, which would make it easier for readers to grasp the overall logic. 2. Regarding the article content • When discussing the advantages of low - dose tetracycline, besides comparing the eradication rates and adverse events with the standard - dose tetracycline, could the possible mechanism of action be further explored? This would help readers understand the research results more in - depth. • Some factors affecting the Helicobacter pylori eradication rate are mentioned in the article, such as patient compliance, smoking history, etc. However, could a more in - depth analysis of the interactions between these factors be carried out? For example, does smoking affect the eradication rate by influencing compliance? • Regarding the content of the gut microbiota, although it is mentioned in the limitations that the impact of the low - dose tetracycline regimen on the gut microbiota has not been studied, could the future research directions be more specifically elaborated on how to design relevant studies to explore this issue? 3. Regarding the charts • There is a lot of data in the tables in the article, and some abbreviations in the tables may confuse readers. Could more detailed explanations be given below the tables or where the abbreviations first appear? • Could the titles of the charts more clearly reflect the core content of the charts? For example, some chart titles only simply describe the variables involved in the charts without highlighting the main conclusions or trends. • Could some more charts be considered to present the key information in the research more intuitively? For example, charts could be used to show the occurrence trends of adverse events in different tetracycline dose groups during the treatment process, or to present the relative magnitudes of the impacts of different factors on the eradication rate. 4.Further study • It would be interesting to see if the results hold true in different populations and geographical regions. • The study could have included a more detailed analysis of the long - term effectiveness and potential recurrence of H. pylori infection after treatment. "
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Zhao YR, Wang XJ, Zhu MJ, Chen AL, Zhang D, Du Q, Kim JJ, Hu WL. Efficacy and safety of low-dose tetracycline, amoxicillin quadruple therapy in Helicobacter pylori infection: A retrospective single center study. World J Gastroenterol 2024; 30(39): 4295-4304
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"This paper conducts an in-depth study on the effects of invigorating-spleen and anticancer prescription (ISAP) in a mice model of ..."
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"This paper conducts an in-depth study on the effects of invigorating-spleen and anticancer prescription (ISAP) in a mice model of colon cancer, providing valuable experimental data and analysis. Here are some of my comments on the paper: 1. Clear research background: The paper begins with a detailed introduction to the epidemiological data of colon cancer, emphasizing the severity of the disease and the limitations of existing treatment methods, providing a good background for the necessity of the study. 2. Reasonable experimental design: The study established a mice model of colon cancer and divided it into several experimental groups (including a control group and groups with different doses of ISAP), a design that effectively compares the effects of different doses of ISAP on tumor suppression. 3. Detailed data analysis: The paper provides detailed data on the measurement of mice weight, tumor inhibition rate, and related protein expression levels, with clear and understandable results. These data provide empirical support for the anti-tumor mechanism of ISAP. 4. In-depth mechanism exploration: By analyzing key proteins in the ERK/MAPK signaling pathway, the paper explores the potential mechanism of action of ISAP, providing new ideas for subsequent research. 5. Clinical significance: Although the study has achieved positive results in the mice model, the effectiveness and safety of ISAP still need to be verified in clinical trials. This point can be further emphasized in the discussion section. 6. Language and structure: The language of the paper is relatively fluent, with a clear structure, making it easy for readers to understand. However, the explanation of some professional terms could be more detailed, for the understanding of non-professional readers. Overall, this paper provides strong support for the potential of ISAP in the treatment of colon cancer, looking forward to seeing more clinical research results in the future. "
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Wang W, Wang J, Ren XX, Yue HL, Li Z. Effects of invigorating-spleen and anticancer prescription on extracellular signal-regulated kinase/mitogen-activated protein kinase signaling pathway in colon cancer mice model. World J Gastrointest Oncol 2024; 16(11): 4468-4476
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"The original article by Wang FD et al., "Gamma-aminobutyric acid enhances miR-21-5p loading into adipose-derived stem cell ..."
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"The original article by Wang FD et al., "Gamma-aminobutyric acid enhances miR-21-5p loading into adipose-derived stem cell extracellular vesicles to alleviate myocardial ischaemia-reperfusion injury via TXNIP regulation," is very good. GABA-induced miR-21-5p-loaded EVs utilise a unique mechanism to lessen myocardial ischaemia-reperfusion injury (MIRI) and present a novel method for managing MIRI through oxidative stress modulation. The study reported that miR-21-5p exerts its effects through a direct interaction with TXNIP in cardiomyocytes, thereby triggering oxidative stress and elucidating related molecular mechanisms. Furthermore, this work systematically employs in vivo, in vitro, and a variety of imaging methods with gene knockout models to provide comprehensive methodological proofs. Considering myocardial ischaemia is a common clinical condition, this study has high translational relevance. But there are few queries: The experiment only evaluates its EV source in inguinal ADSCs and could miss other potential beneficial configurations of EV. It is still unclear whether these short-term therapeutic effects are sustainable or if they interfere with repeated dosing against MIRI, despite the study's lack of a long-term assessment. The process of producing, standardizing, and ensuring the safety of EVs for human use could potentially complicate the clinical translation of the latter strategy. "
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Wang FD, Ding Y, Zhou JH, Zhou E, Zhang TT, Fan YQ, He Q, Zhang ZQ, Mao CY, Zhang JF, Zhou J. Gamma-aminobutyric acid enhances miR-21-5p loading into adipose-derived stem cell extracellular vesicles to alleviate myocardial ischemia-reperfusion injury via TXNIP regulation. World J Stem Cells 2024; 16(10): 873-895
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"Although this Letter is limited in length, the discussion on the gender differences in the effects of Xiaoyao San (XYS) in different ..."
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"Although this Letter is limited in length, the discussion on the gender differences in the effects of Xiaoyao San (XYS) in different animal models appears overly simplistic. The article mentions the estrogen receptor-related mechanism but does not provide sufficient background or data to support the specific impact of gender differences on metabolism and therapeutic efficacy. This makes the discussion of gender differences somewhat superficial, failing to adequately explain how these differences influence the mechanism of XYS. Additionally, the reliance on network pharmacology predictions without experimental validation weakens the scientific robustness of the conclusions. Even in a short Letter, when addressing complex mechanisms, the arguments should remain clear and well-supported. "
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Qiu XX, Li Z. Bioactive constituents and action mechanism of Xiaoyao San for treatment of non-alcoholic fatty liver disease. World J Hepatol 2024; 16(10): 1213-1215
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"The theme of this article is very practical and a common problem that troubles elderly women, and the conclusion is very meaningful. ..."
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"The theme of this article is very practical and a common problem that troubles elderly women, and the conclusion is very meaningful. It can help alleviate the pain of many women. The abundant scientific data and clear images fully demonstrate the role of exercise therapy, providing methods and ideas for further research.As a reader, I really enjoy this article as it allows me to quickly gain knowledge about this topic. "
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Dai ZQ, Gong XY, Zhang R, Jin MQ, Lu W, Wen W, Chen J, Lu FJ, Yang YF, Wang L, He XJ. Research trends in exercise therapy for the treatment of pain in postmenopausal osteoporosis over the past decade: A bibliometric analysis. World J Orthop 2024; 15(10): 950-964
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"This article is interesting, but does not provide any novelties nor scientific approaches in diagnostics of IBD, it is based on ..."
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"This article is interesting, but does not provide any novelties nor scientific approaches in diagnostics of IBD, it is based on "defending" physicians and minorizing their role in detecting Crohn's disease. I could agree with main conclusion of this article, that providing a diagnose of Crohn's disease is multifactorial, and it depends not only on physicians but on patients itself, time frame, diagnostic abilities. "
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Zeng Y, Zhang JW, Yang J. Physician-dependent diagnosis delay in Crohn's disease: A pseudo-proposition or not? World J Gastroenterol 2024; 30(38): 4242-4245
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"1. This study lacks an ethics statement. It is advisable to include an ethics statement within the methods section. 2. The ROC curve ..."
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"1. This study lacks an ethics statement. It is advisable to include an ethics statement within the methods section. 2. The ROC curve presented in the results suggests that the sample size may be relatively insufficient. It is recommended that researchers increase the sample size in further studies and conduct prospective investigations to validate these findings. "
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Lin BS, Liu ZG, Chen DR, Yang YL, Yang DZ, Yan JH, Zeng LY, Yang XB, Xu W. Relationship between hemoglobin glycation index and risk of hypoglycemia in type 2 diabetes with time-in-range in target. World J Diabetes 2024; 15(10): 2058-2069
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"Title: A Study on the Deterioration of Intracranial Epidermoid Cysts through Whole Exome Sequencing Dear Editors and Authors, First ..."
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"Title: A Study on the Deterioration of Intracranial Epidermoid Cysts through Whole Exome Sequencing Dear Editors and Authors, First and foremost, I would like to congratulate the authors on the publication of this high-quality case report on the malignant transformation of intracranial epidermoid cysts (IEC) into squamous cell carcinoma (SCC) in the "World Journal of Clinical Oncology." This study not only provides valuable insights into the molecular mechanisms underlying the transformation of IEC to SCC but also reveals two potential disease-related gene mutations: GJB2 (c.257C>T) and TLR2 (c.1039A>G) through whole exome sequencing (WES). Comment Content: Innovation and Importance of the Study: The innovation of this study lies in providing the first clinical evidence for the potential role of GJB2 and TLR2 in the development and treatment of IEC. This is significant for guiding future research directions and potential therapeutic targets. Rigorous Study Design: The authors have employed WES technology, which is efficient and cost-effective for processing large amounts of data quickly. This method is highly applicable for screening genetic variants related to rare and complex diseases, demonstrating the rigor and forward-thinking of the study design. Detailed Case Report: The article provides a very detailed description of the case, including the patient's clinical symptoms, medical history, laboratory test results, and imaging examination results. These details help readers to fully understand the case and provide valuable data for future research. In-Depth Analysis of Genetic Variants: The authors not only identified two risk variants but also conducted an in-depth analysis of their impact on protein structure and function. This in-depth analysis helps to understand how these variants affect the occurrence and development of the disease. Comprehensive Treatment and Follow-Up: The article describes the patient's treatment process and follow-up results in detail, providing valuable references for clinical doctors and demonstrating the effectiveness of comprehensive treatment in controlling the condition. Suggestions for Improvement: Increase the Sample Size: Although this is a report on a rare case, increasing the sample size will help to verify the association between these gene mutations and the deterioration of IEC and improve the generalizability and reliability of the study's results. Functional Validation Experiments: The authors mentioned plans for functional validation experiments in future studies. These experiments will help further confirm the role of GJB2 and TLR2 in the development of IEC and how these mutations affect protein function. Long-Term Follow-Up Data: Long-term follow-up data will help assess the long-term effects of treatment and the patient's quality of life, which is crucial for evaluating treatment outcomes and formulating treatment guidelines. Conclusion: This article is an important contribution to the study of the mechanisms underlying the malignant transformation of IEC. It not only enhances our understanding of the genetic basis of this rare disease but also provides new ideas for future treatments. The authors' work is commendable, and I look forward to their future research bringing more breakthrough "
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Song ZN, Cheng Y, Wang DD, Li MJ, Zhao XR, Li FW, Liu Z, Zhu XR, Jia XD, Wang YF, Liang FF. Whole exome sequencing identifies risk variants associated with intracranial epidermoid cyst deterioration: A case report. World J Clin Oncol 2024; 15(11): 1428-1434
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"The combination of Astragalus polysaccharide and gimeracil oteracil potassium capsule (S-1) in the treatment of pancreatic cancer ..."
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"The combination of Astragalus polysaccharide and gimeracil oteracil potassium capsule (S-1) in the treatment of pancreatic cancer can effectively improve the efficacy, reduce side effects, and increase long-term survival rates, which has significant clinical value.In the future, we can further validate its efficacy by conducting prospective, large-scale, multi-center studies and provide more guiding recommendations for clinical practice. "
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Li GY, Jiang J. Recent efficacy and long-term survival of Astragalus polysaccharide combined with gemcitabine and S-1 in pancreatic cancer. World J Clin Oncol 2024; 15(11): 1404-1411
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"Commentary: Predictors of survival in autoimmune liver disease overlap syndromes Jian-Guo Zhang,Biao Wen Jian-Guo Zhang,Biao ..."
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"Commentary: Predictors of survival in autoimmune liver disease overlap syndromes Jian-Guo Zhang,Biao Wen Jian-Guo Zhang,Biao Wen,Department of Gastroenterology, The First Affiliated Hospital of Chengdu Medical College, Chengdu 610000, Sichuan Province, China Author contributions:Jian-Guo Zhang wrote the original draft; Biao Wen contributed to conceptualization, writing, reviewing and editing; Jian-Guo Zhang and Biao Wen participated in drafting the manuscript; and all authors have read and approved the final version of the manuscript. ORCID number：0000-0001-5226-5981 Corresponding author:Biao Wen,MD, PhD,Assistant Professor,Department of Gastroenterology, The First Affiliated Hospital of Chengdu Medical College,No. 312, Middle Section of Baoguang Avenue, Xindu District, Chengdu 610000, Sichuan Province, China. 820695761@qq.com We perused the article authored by Jayabalan et al[1]with considerable interest and extend our congratulations to the authors for their commendable endeavor. The authors have reported a prospective investigation into the predictors of survival in patients with autoimmune liver disease overlap syndromes (AILDOS)[1]. The study's conclusion suggests that the LOS holds potential as a predictive tool for liver-related mortality in individuals with autoimmune hepatitis and primary biliary cholangitis overlap (AIH-PBC)[1]. However, several aspects of this study merit further scrutiny and discussion. Firstly, a critical exclusion criterion for the study was the prior performance of a liver transplant prior to enrollment[1]. Upon consideration, we postulated the possibility that a portion of the enrolled patients might harbor coexisting liver pathology stemming from disparate causes (including, but not limited to, alcoholic liver disease or viral hepatitis), which could introduce bias and complicate the interpretation of our results. Therefore, we advised the authors to implement rigorous exclusion criteria for such patients to uphold the accuracy and reliability of our findings. Secondly, the diagnoses of autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC), and primary sclerosing cholangitis (PSC) were established in accordance with the criteria stipulated by the International Autoimmune Hepatitis Group, the European Association for the Study of the Liver Clinical Practice Guidelines, and the American College of Gastroenterology Clinical Guidelines, respectively[1-4]. It is noteworthy that these diagnostic criteria originate from disparate geographical regions, and the progression of research concerning each disease varies across these regions. Consequently, such variability may potentially impact the precision of the study's findings. In light of this, we propose that the authors consider adopting diagnostic criteria from a uniform geographical region. Therefore, we recommend the uniform application of diagnostic guidelines or consensus recommendations established by reputable institutions in the United States for the purposes of disease ascertainment. Such standardization is poised to substantially elevate the reliability and validity of the research findings, thereby reinforcing the scientific rigor and credibility of the conducted studies.[4-6]. Thirdly, the authors confined their analysis solely to the occurrence or absence of liver-related mortality, while neglecting to account for the medical interventions undergone by the patients during the follow-up period[1]. It is imperative to elucidate the potential impact of these interventions on the study's findings. A comprehensive assessment of the medical interventions received by the patients is crucial for ensuring the accuracy and robustness of the study's conclusions. Ultimately, as highlighted by the authors, the primary limitation of this study is the relatively modest sample size[1]. Consequently, it is imperative that future research endeavors incorporate larger sample populations and adopt a multicenter design to validate the findings of the present study and further elucidate the pertinence to patients with AIH-PSC. Conflict-of-interest statement: No potential conflicts of interest relevant to this article were reported. REFERENCES 1 Jayabalan D, Huang Y, Calzadilla-Bertot L, Janjua M, de Boer B, Joseph J, Cheng W, Hazeldine S, Smith BW, MacQuillan GC, Wallace MC, Garas G, Adams LA, Jeffrey GP. Predictors of survival in autoimmune liver disease overlap syndromes. World J Hepatol 2024; 16: 1269-1277. [PMID:39351512 DOI: 10.4254/wjh.v16.i9.1269] 2 European Association for the Study of the Liver. EASL Clinical Practice Guidelines: The diagnosis and management of patients with primary biliary cholangitis. J Hepatol 2017; 67: 145-172. [PMID: 28427765 DOI: 10.1016/j.jhep.2017.03.022] 3 Czaja AJ. Diagnosis and Management of Autoimmune Hepatitis: Current Status and Future Directions. Gut Liver 2016; 10: 177-203. [PMID:26934884 DOI: 10.5009/gnl15352] 4 Lindor KD, Kowdley KV, Harrison ME. ACG Clinical Guideline: Primary Sclerosing Cholangitis. Am J Gastroenterol 2015; 110: 646-659, 660. [PMID: 25869391 DOI: 10.1038/ajg.2015.112] 5 Mack CL, Adams D, Assis DN, Kerkar N, Manns MP, Mayo MJ, Vierling JM, Alsawas M, Murad MH, Czaja AJ. Diagnosis and Management of Autoimmune Hepatitis in Adults and Children: 2019 Practice Guidance and Guidelines From the American Association for the Study of Liver Diseases. Hepatology 2020; 72: 671-722. [PMID: 31863477 DOI: 10.1002/hep.31065] 6 Lindor KD, Bowlus CL, Boyer J, Levy C, Mayo M. Primary Biliary Cholangitis: 2018 Practice Guidance from the American Association for the Study of Liver Diseases. Hepatology 2019; 69: 394-419. [PMID:30070375 DOI: 10.1002/hep.30145] "
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Jayabalan D, Huang Y, Calzadilla-Bertot L, Janjua M, de Boer B, Joseph J, Cheng W, Hazeldine S, Smith BW, MacQuillan GC, Wallace MC, Garas G, Adams LA, Jeffrey GP. Predictors of survival in autoimmune liver disease overlap syndromes. World J Hepatol 2024; 16(9): 1269-1277
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"Comment on “Mesenchymal stem cells in wound healing: A bibliometric analysis as a powerful research tool” Shuang Wu, Hong Cai* ..."
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"Comment on “Mesenchymal stem cells in wound healing: A bibliometric analysis as a powerful research tool” Shuang Wu, Hong Cai* Corresponding author: Hong Cai, Department of Dermatology, Air Force Medical Center, PLA, Beijing, 100142, P. R. China. ch1031@163.com Affiliation: Department of Dermatology, Department of Dermatology, Air Force Medical Center, PLA. No.30 of Fucheng Road. Beijing 100142, China. Key Words: Bibliometric analysis; Mesenchymal stem cells; Wound healing; To the Editor: We read the editorial by Vera et al [1]with great interest. In this editorial, the author conducted a keyword comparison and analysis of basic research published in BPG from 2023 to 2024, utilizing the bibliometric analysis approach of Shi et al[2]. This emphasizes the effectiveness of bibliometric analysis as a research tool. Additionally, the author examined several other articles on BPG, excluding WJSC, that were not included in Shi et al.'s bibliometric analysis. The findings indicate that although the application of bibliometric analysis in basic research remains limited, it can help identify key research directions and challenges in the field, advance the application of MSCs in the treatment of chronic wounds, and facilitate comprehensive analysis of related literature to better understand the current state of research and future development potential. First, the author conducted a keyword analysis of basic research on diabetic foot published in BPG, utilizing the bibliometric analysis by Shi et al. to highlight the value of bibliometric analysis in this field, which can provide clear directions for research hotspots. However, while Shi et al. used the Web of Science Core Collection database, the author of this article relied solely on the database affiliated with BPG for keyword comparisons. This discrepancy might introduce potential biases in the analysis results due to differences in research directions and acceptance criteria between journals[3,4]. Second, the author also pointed out limitations in Shi et al.'s bibliometric analysis: the analysis primarily focused on journals related to diabetic foot, while literature from other relevant fields was excluded from the search. This implies that some articles pertaining to stem cell therapy for diabetic foot may not have been incorporated, underscoring the necessity of expanding the search scope in future bibliometric analyses. Third, the author specifically analyzed literature on stem cell therapy for diabetic foot published in BPG during 2023-2024, while Shi et al.'s bibliometric analysis covered related literature from 2000 to 2023, thereby including a broader time span and a more extensive range of keywords. As basic research evolves, there may be past hotspot keywords that are now rarely used, or new research hotspots published in BPG that were not included in Shi et al.'s bibliometric analysis[5]. In summary, this is an editorial that employs bibliometric analysis to conduct a keyword analysis of relevant papers published in BPG from 2023 to 2024, elucidating the role of bibliometric analysis in basic research. If the analysis were to consider the acceptance criteria of different journals and the issue of timeliness more extensively, the conclusions could potentially be more compelling. References 1 Voinova VV, Vasina DV, Bonartsev AP. Mesenchymal stem cells in wound healing: A bibliometric analysis as a powerful research tool. World J Stem Cells 2024; 16: 827–831. [PMID: 39351262 DOI: 10.4252/wjsc.v16.i9.827] 2 Shi H-S, Yuan X, Wu F-F, Li X-Y, Fan W-J, Yang X, Hu X-M, Liu G-B. Research progress and challenges in stem cell therapy for diabetic foot: Bibliometric analysis and perspectives. World J Stem Cells 2024; 16: 33–53. [PMID: 38292441 DOI: 10.4252/wjsc.v16.i1.33] 3 Frank E. Authors’ Criteria for Selecting Journals. JAMA 1994; 272: 163–164. [DOI: 10.1001/jama.1994.03520020089026] 4 Garfield E. The History and Meaning of the Journal Impact Factor. JAMA 2006; 295: 90–93. [DOI: 10.1001/jama.295.1.90] 5 Tversky A, Kahneman D. Judgment under Uncertainty: Heuristics and Biases. Science 1974; 185: 1124–1131. [DOI: 10.1126/science.185.4157.1124] "
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Voinova VV, Vasina DV, Bonartsev AP. Mesenchymal stem cells in wound healing: A bibliometric analysis as a powerful research tool. World J Stem Cells 2024; 16(9): 827-831
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"The article by Shen et al. offers important insights into the need for better screening practices for primary nasal tuberculosis (TB) ..."
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"The article by Shen et al. offers important insights into the need for better screening practices for primary nasal tuberculosis (TB) in patients receiving tumor necrosis factor inhibitor (TNFi) therapy. The rarity of primary nasal TB, due to the nasal mucosa's natural defenses, along with the identified risk factors like diabetes, minimally invasive nasal surgery, and HIV, is well highlighted. We completely agree with the authors about the importance of early detection, especially in high-risk individuals. Their suggestion to increase screening frequency using the Interferon Gamma Release Assay (IGRA) makes sense. However, it’s also worth considering how practical this approach is in areas with lower TB prevalence. In regions with fewer resources, a more targeted strategy based on local TB rates and individual patient risk might be more appropriate. Another point to consider is how clinicians can best decide on the timing of these screenings. While IGRA testing is key, decisions on how often to test should also factor in a patient’s specific history, immune status, and any symptoms they might be experiencing. A one-size-fits-all approach may not work, so a more flexible screening schedule, tailored to both the patient’s needs and the region’s TB prevalence, could be even more effective. We look forward to further research in this area which will help shape future guidelines for managing TB risk in this patient group. "
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Shen DX, Wang YW, Lin ZM, Jin D, Ying ZH, Li C. Early screening to identify and diagnose primary nasal tuberculosis in patients with tumor necrosis factor inhibitors. World J Clin Cases 2024; 12(33): 6604-6607
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"First, I would like to congratulate the authors for their excellent work that reports precisely the role of ultrasonography as the ..."
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"First, I would like to congratulate the authors for their excellent work that reports precisely the role of ultrasonography as the first step in diagnosing liver echinococcus cyst. The paper is comprehensive and well-written, accompanied by many impressive imaging figures. Echinococcosis or hydatid disease is caused mainly by the dog tapeworm Echinococcus granulosus and occasionally by the fox tapeworm Echinococcus multilocularis (alveolaris). Infection by the former exhibits a rather chronic, benign course. Infection by the latter, seen in north and central Europe, Switzerland, Alaska, Canada, Russia, Japan, and China, resembles carcinoma and without treatment is ultimately fatal; there have been reports mistaking it for hepatic carcinoma. The hydatid disease predominantly affects the liver, and surgical management, despite its difficulties and high recurrence rates, is considered the cornerstone of treatment. The incidence of liver echinococcal cyst has considerably reduced across the world owing to concerted public health hygiene and sanitary measures to disrupt the parasite cycle between the main host (dog,wolf, fox) and the intermediate host (human, sheep, cow, pig), but it remains endemic in some areas.. Diagnosis is established by current imaging techniques (US, CT, MRI-MRCP), aided by serum serology tests for antibodies against hydatid antigens. Specific anti-echinococcal antibodies (IgG, IgM), detected by ELISA (with a sensitivity of 95–97%) is the most widely used serologic test in everyday practice. Modern MRI depicts accurately the details of a hepatic echinococcal cyst as well as the communication with the biliary tree. MRCP showing dilatation of the biliary tract and echinococcal material in it may be valuable. Surgery is the main treatment modality in the management of liver echinococcosis caused by echinococcus granulosus, especially in large solitary cysts. It includes the most demanding radical procedures (total pericystectomy or hepatectomy) and the more conservative procedures (cyst evacuation, partial cystectomy, and drainage or omentoplasty). Complete removal of the cyst ensures permanent cure and should be the treatment of first-choice. In contrast, liver echinococcosis caused by echinococcus multilocularis (alveolaris) is not usually amenable to surgical treatment, except in drug therapy by Albendazole. It is used at a dose of 10 mg/kg/day. One tablet of 400 mg twice daily is the usual therapeutic scheme. A cycle of 28 days is recommended, followed by a washout period of 14 days, and repetition again. "
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Tao Y, Wang YF, Wang J, Long S, Seyler BC, Zhong XF, Lu Q. Pictorial review of hepatic echinococcosis: Ultrasound imaging and differential diagnosis. World J Gastroenterol 2024; 30(37): 4115-4131
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"This retrospective study provide a machine learning method using nomogram to present medical imaging features associated with clinical ..."
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"This retrospective study provide a machine learning method using nomogram to present medical imaging features associated with clinical factors via univariate and multivariate analysis in patients with colon cancer. Maybe the results of CT imaging with 12 characteristics as author stated is interesting for readers in clinic diagnosis as well as these representative images can be shared by your database online. "
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Hu ZX, Li Y, Yang X, Li YX, He YY, Niu XH, Nie TT, Guo XF, Yuan ZL. Constructing a nomogram to predict overall survival of colon cancer based on computed tomography characteristics and clinicopathological factors. World J Gastrointest Oncol 2024; 16(10): 4104-4114
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"This article has explained the effects of mesenchymal stem cells and their derivatives in the non-alcoholic fatty liver disease and ..."
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"This article has explained the effects of mesenchymal stem cells and their derivatives in the non-alcoholic fatty liver disease and alcohol-associated liver disease using mouse models. Maybe it is meaningful to indicate the application of mesenchymal stem cells in fatty liver in the future. Hope that interaction between mesenchymal stem cells and human hepatic cell lines can be investigated to explore this effective role for further use in the clinic. "
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Gao FQ, Zhu JQ, Feng XD. Innovative mesenchymal stem cell treatments for fatty liver disease. World J Stem Cells 2024; 16(9): 846-853
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