Baishideng Publishing Group

Bontsiou I, Tzikos G, Chorti A, Vouchara A, Menni A, Papaioannou M, Kotzampassi K, Papavramidis TS. Vitamin D and inflammatory bowel diseases. World J Gastroenterol 2026; 32(28): 116790

"We are grateful for the opportunity to publish in World Journal of Gastroenterology. However, after the manuscript was initially ..." [Read more]

"We are grateful for the opportunity to publish in World Journal of Gastroenterology. However, after the manuscript was initially accepted as a Letter to the Editor, we were subsequently asked to revise it into an Opinion Review with substantially expanded references, which caused considerable confusion and delay. We hope the editorial workflow can be streamlined to avoid such inconsistencies between acceptance decisions and subsequent requests in the future. Thank you for your consideration. " [Collapse]

Zhou PM, Yang CT, Bao JF, Huang JS. Letter to the Editor: Precise phenotyping clarifies uric acid-to-high-density lipoprotein cholesterol ratio for cardiovascular risk in metabolic dysfunction-associated steatotic liver disease. World J Gastroenterol 2026; 32(29): 119060

"It was a great experience. The process of invitations, selecting the subject,and reviewing were excellent. There was some delay in ..." [Read more]

"It was a great experience. The process of invitations, selecting the subject,and reviewing were excellent. There was some delay in publishing process but of the range in expectation. I was surprised at first of changing the manuscript type from review to letter to the editor but later i realized that this was more appropriate. Thank you " [Collapse]

Fouad Y, Gomaa A, Esmat G. Letter to the Editor: Decoding intrahepatic cholangiocarcinoma through lactate metabolism - from cellular states to therapeutic targets. World J Gastroenterol 2026; 32(29): 118233

"1. Author's Evaluation of the Journal's Credibility We are highly satisfied with the editorial and publishing rules, norms, and overall ..." [Read more]

"1. Author's Evaluation of the Journal's Credibility We are highly satisfied with the editorial and publishing rules, norms, and overall process of the World Journal of Gastroenterology. From submission to final online publication, the entire workflow demonstrated exceptional professionalism and rigor. The journal adheres to clear ethical and publication standards, with transparent editorial decisions and a reasonable timeline. The final layout of the article and the quality of the online full-text version are excellent. We have full confidence in the academic integrity and publishing standards of this journal and consider it a trustworthy and prestigious venue for scholarly communication. 2. Author's Evaluation of the Journal's Peer Review The peer-review process was rigorous, objective, and highly constructive. The reviewers provided in-depth and professional evaluations of our scientific content, research methodology, and data analysis. Their comments were pertinent, insightful, and directly helped us substantially improve the scientific validity, logical structure, clarity, and readability of our manuscript. The entire review process was efficiently managed, and communication with the editorial office was clear and prompt, making the revision and response process smooth and straightforward. We are deeply grateful to the reviewers and the editorial team for their time, expertise, and valuable contributions. 3. Comments (Overall Evaluation and Suggestions for the Editorial and Production Team) We would like to take this opportunity to express our sincere gratitude to the entire publication team—including the assistant editors, handling editors, reviewers, language editors, and production editors—for their dedicated work and professional support throughout the editorial and publication process. From the review and revision stages to the final proofreading and production, we received expert guidance and timely responses at every step, resulting in a very smooth, positive, and rewarding publishing experience. As a minor suggestion for future improvement, we would note that reducing the time between final acceptance and online publication would make an already excellent process even more seamless and efficient. Nevertheless, this does not diminish our overall high satisfaction with this publication experience. Once again, we sincerely thank the journal for providing us with this outstanding platform to disseminate our research. We would be very pleased to submit our future work to the World Journal of Gastroenterology and would highly recommend it to our colleagues and peers in the field. " [Collapse]

Chai J, Wang ZY, Weng ZJ, Zhang ZJ, Wu LY, Zhang F, Cao LL, Chen ZY, Wu HG, Liu HR. Role of physical therapy in irritable bowel syndrome: Current strategies and prospective options. World J Gastroenterol 2026; 32(29): 118105

"I had a very positive overall experience publishing with this journal. The editorial team was highly professional, responsive, and ..." [Read more]

"I had a very positive overall experience publishing with this journal. The editorial team was highly professional, responsive, and supportive throughout the entire process from submission to final online publication. The peer-review comments were constructive, detailed, and insightful, which significantly helped improve the scientific rigor, clarity, and overall quality of our manuscript. Communication from the editorial office was timely, clear, and efficient at every stage, and the publication workflow was smooth, transparent, and well-organized. I truly appreciate the high-quality service provided to researchers and would be happy to consider submitting my future work to this journal. " [Collapse]

Lu Y, Zhou XL, Chen F. Letter to the Editor: Spinal IL-33/ST2 blockade for gallbladder carcinoma pain - balancing central analgesia with systemic tumor immune microenvironment risks. World J Gastrointest Oncol 2026; 18(7): 121633

"he purpose of an author’s evaluation of a journal’s credibility is to assess the degree of satisfaction with the manuscript editing ..." [Read more]

"he purpose of an author’s evaluation of a journal’s credibility is to assess the degree of satisfaction with the manuscript editing and publishing process. This evaluation is for user’s reference only.satisfied with the editing and publishing rules and norms,satisfied with the editing and publishing rules and norms,satisfied with the editing and publishing rules and norms " [Collapse]

Xiong HB, Cao QX, Deng W, Zhou HG, Lai XT, Zhang QQ, Li J. Risk factors for inadequate bowel preparation: A retrospective study of 7931 paired colonoscopy cases with a predictive model. World J Gastrointest Endosc 2026; 18(7): 122582

"The publication process was smooth, efficient, and well managed from submission to final publication. The peer-review process was ..." [Read more]

"The publication process was smooth, efficient, and well managed from submission to final publication. The peer-review process was thorough and constructive, with insightful comments that significantly improved the scientific quality and clarity of our manuscript. We sincerely appreciate the professionalism and responsiveness of the editorial office throughout the review, revision, and production stages. The timely communication and transparent editorial process made the entire publishing experience both positive and rewarding. We would like to express our gratitude to the reviewers, editors, and production team for their valuable contributions and commitment to maintaining high scientific and ethical standards. It is an honor to have our work published in the World Journal of Orthopedics, and we look forward to future opportunities to collaborate with the journal. " [Collapse]

Emara KM, Diab RA, Hussein M, Abuelwafa M, Eissa MO. Clinical considerations in intramedullary headless screw fixation of metacarpal and proximal phalanx fractures. World J Orthop 2026; 17(7): 120372

"I am deeply impressed by the rigorous academic standard and efficient editorial service of this journal throughout the whole submission ..." [Read more]

"I am deeply impressed by the rigorous academic standard and efficient editorial service of this journal throughout the whole submission process. The peer reviewers provided extremely professional, detailed and constructive comments, which have greatly helped me revise and polish this manuscript. I sincerely appreciate the dedicated work of the journal editorial team and all reviewers, and I hold high recognition for the journal’s rigorous academic atmosphere and standardized review mechanism. " [Collapse]

Fu Y. Letter to the Editor: Probiotics counteract polyethylene glycol bowel preparation dysbiosis and infection risk. World J Gastroenterol 2026; 32(28): 118993

"We are delighted to have our article published in the World Journal of Gastroenterology. The journal provides an excellent platform ..." [Read more]

"We are delighted to have our article published in the World Journal of Gastroenterology. The journal provides an excellent platform for disseminating clinically relevant and timely research to the international gastroenterology community. We sincerely appreciate the professional editorial process, the constructive peer-review comments, and the support provided by the editorial team throughout the publication process. We hope that our article will contribute to ongoing discussions and help improve clinical practice in the field of inflammatory bowel disease. " [Collapse]

Nguyen CD, Dang LM. Biosimilars in inflammatory bowel disease: Beyond evidence, toward trust and implementation. World J Gastroenterol 2026; 32(28): 119462

"I would like to express my sincere gratitude and satisfaction with the entire publication process of our manuscript. The editorial ..." [Read more]

"I would like to express my sincere gratitude and satisfaction with the entire publication process of our manuscript. The editorial team, reviewers, and production staff have demonstrated exceptional professionalism and efficiency. The peer review was thorough and constructive, significantly improving the quality of our work. The online submission and tracking system was user-friendly, and the communication from the editorial office was timely and clear. I truly appreciate the collaborative efforts that made this experience smooth and positive. I am confident that the journal maintains high standards, and I look forward to future collaborations. " [Collapse]

Zhan PW, Wang T. Letter to the Editor: Comparable outcomes of sevoflurane vs propofol anesthesia in gastrectomy for gastric cancer. World J Gastrointest Oncol 2026; 18(7): 116791

"We greatly appreciate the editorial team’s dedicated work and professional support throughout the manuscript handling, peer-review, ..." [Read more]

"We greatly appreciate the editorial team’s dedicated work and professional support throughout the manuscript handling, peer-review, revision, and publication processes. We are also deeply grateful to the reviewers for their careful evaluation of our manuscript and for providing insightful, constructive, and professional comments. These valuable suggestions helped us further improve the scientific quality, rigor, clarity, and readability of the article.The successful publication of our work would not have been possible without the efficient and rigorous efforts of the editorial team and the objective and expert guidance of the reviewers. We have benefited greatly from the entire submission and revision process, which has also provided valuable inspiration for our future research.Once again, we sincerely thank the editorial team and the reviewers for their time, effort, and professional contributions. We wish the journal continued success and an ever-growing academic impact. " [Collapse]

Chen L, Song HC, Meng FZ, Zhang SY, An ZY, Ling XY, Zhang C, Zhu XC, Wang JZ, Song RP, Liu LX. Impact of textbook outcome after hepatectomy for colorectal metastases on salvage curative-intent treatment at recurrence. World J Gastrointest Oncol 2026; 18(7): 120704

"We are truly honored to have our Editorial published in World Journal of Gastroenterology. On behalf of all co-authors, we would like ..." [Read more]

"We are truly honored to have our Editorial published in World Journal of Gastroenterology. On behalf of all co-authors, we would like to express our sincere gratitude to the Editor-in-Chief, handling editors, peer reviewers, and the entire publishing team for their dedication and professionalism. Throughout the submission, revision, and publication process, we experienced a highly efficient, transparent, and rigorous workflow. The peer-review comments were exceptionally constructive and insightful, which not only substantially improved the scientific quality of our manuscript but also inspired us to further explore the clinical decision-making pathways for hepatic cystic echinococcosis. The timely communication and meticulous attention to detail at every stage reflected the highest standards of an international academic journal. We also sincerely appreciate Baishideng Publishing Group for providing an excellent platform and comprehensive support for academic dissemination. The open-access model has enabled our work to reach a broad audience of researchers and clinicians worldwide, facilitating rapid academic exchange. We fully support the journal’s commitment to scientific excellence and open dissemination, and we will continue to follow its future progress. We sincerely wish World Journal of Gastroenterology continued success in leading the field. " [Collapse]

Zhang XY, Li BQ, Cao WN, Zhang ZL, Xin Q, Jia KF. Percutaneous vs surgical management of hepatic cystic echinococcosis: A perspective on evolving clinical pathways. World J Gastroenterol 2026; 32(28): 118370

"We are deeply grateful to the reviewers and editorial team for their thoughtful and detailed feedback, which has greatly strengthened ..." [Read more]

"We are deeply grateful to the reviewers and editorial team for their thoughtful and detailed feedback, which has greatly strengthened our manuscript. The publication process from submission to acceptance was seamless, reflecting the high level of professionalism at your journal. Thank you for providing us with this valuable opportunity. We sincerely appreciate your continued guidance and support. " [Collapse]

Liu BQ, Sun ZF, Ning CH, Xiao J, Wu D, Lin CY, Hong XY, Guo R, Chen L, Cao XT, Shen DC, Huang GW. Machine learning-driven pathogen cluster analysis identifies high-risk subtypes of infected pancreatic necrosis in a multi-center cohort. World J Gastroenterol 2026; 32(27): 118717

"We sincerely appreciate the valuable comments from the reviewers and editorial team, which greatly improved our manuscript. The ..." [Read more]

"We sincerely appreciate the valuable comments from the reviewers and editorial team, which greatly improved our manuscript. The submission and publication process was smooth, and we are grateful for the professional support throughout. Thank you for providing us with the opportunity to publish our work. We truly value your continued assistance. " [Collapse]

Izutani Y, Ogino T, Sakakibara S, Kishi Y, Liu YC, Nakano Y, Fukada A, Sekido Y, Kuwahara R, Kihara T, Takeda M, Hata T, Hamabe A, Miyoshi N, Uemura M, Ikeuchi H, Hirota S, Takeda K, Mizushima T, Okuzaki D, Doki Y, Eguchi H. Contribution of the appendix to ulcerative colitis by supplying pathogenic immunoglobulin G-producing cells. World J Gastroenterol 2026; 32(27): 117897

"Throughout my manuscript’s submission and publication journey, I have received professional and standardized services from the journal. ..." [Read more]

"Throughout my manuscript’s submission and publication journey, I have received professional and standardized services from the journal. All submission materials are standardized and easy to prepare, and the overall publishing procedure is systematic and transparent. The journal strictly abides by academic norms and provides authentic and detailed academic integrity inspection results. The peer review arrangement is scientific, and the anonymous evaluation mechanism effectively ensures impartiality. The professional review suggestions greatly assist me in optimizing and improving my research paper. " [Collapse]

Liu YY, Ai JH, Zeng LM, Liu XN, Wu F. Gastric cancer-derived exosomal indoleamine 2,3 dioxygenase 1 drives immunosuppression in gastric cancer by suppressing dendritic cell maturation. World J Gastroenterol 2026; 32(28): 118939

"I had a very positive experience publishing with this journal. The editorial team was professional, responsive, and supportive ..." [Read more]

"I had a very positive experience publishing with this journal. The editorial team was professional, responsive, and supportive throughout the submission process. The peer-review comments were constructive and helped improve the quality of my manuscript. Communication was timely, and the overall publication process was smooth, transparent, and efficient. I would be happy to consider submitting my future research to this journal and would recommend it to fellow researchers. " [Collapse]

Thotungal R, Kaushal A, Agrawal A, Jain A, Waindeskar V, Haldar R, Lokho P. Comparison of propofol alone vs propofol-phenylephrine combination for intraoperative hemodynamic stability in glioma surgery. World J Methodol 2026; 16(3): 117220

"Thank you to the editors reviewers and the editorial office for your support throughout the publication process. The communication ..." [Read more]

"Thank you to the editors reviewers and the editorial office for your support throughout the publication process. The communication was clear and every step was easy to follow. The review process was fair and the comments helped improve our manuscript. We appreciate the time and effort invested by everyone involved. It was a positive experience publishing our work in the World Journal of Gastrointestinal Oncology and we look forward to working with the journal again in the future. " [Collapse]

Algethami N, Valdimarsson V, Verwaal V, Syk I. Prophylactic sodium thiosulfate reduces the risk and severity of acute kidney injury in oxaliplatin-based hyperthermic intraperitoneal chemotherapy. World J Gastrointest Oncol 2026; 18(7): 118400

"I had a positive experience with the submission and peer-review process. The editorial process was generally well organized, ..." [Read more]

"I had a positive experience with the submission and peer-review process. The editorial process was generally well organized, transparent, and efficient. The reviewers provided constructive and relevant comments that helped improve the scientific clarity, methodological description, and overall presentation of our manuscript. Their feedback was professional, detailed, and focused on strengthening the quality of the work. The revision process was also clear and manageable. The editorial requirements and revision instructions were communicated in an understandable manner, which allowed us to respond to the reviewers’ comments systematically and prepare a more rigorous revised manuscript. " [Collapse]

Xiong ZK, Jiang YZ, Lin YH, Cao JD, Deng TY, Zheng YY. Is metabolic dysfunction-associated steatotic liver disease truly irrelevant? Unmasking the heterogeneity and confounders in pancreatic cancer outcomes. World J Gastroenterol 2026; 32(27): 119356

"We have no opinion and are satisfied with the process of submission and final acceptance for publication. Thanks to the hard work ..." [Read more]

"We have no opinion and are satisfied with the process of submission and final acceptance for publication. Thanks to the hard work of the editorial team and reviewers, their suggestions are very constructive for the publication of our paper. The paper was finally published because of these suggestions. I look forward to our better cooperation next time. " [Collapse]

Wang ZP, Zhang HW, Zhao XY, Li YZ, Zhang XG, Zhao R, Qin DP. Intervertebral disc degeneration and aging: Shared molecular mechanisms and therapeutic interventions. World J Orthop 2026; 17(7): 120800

"The editorial process for manuscript 117916 was professional and constructive. Peer review comments were relevant, specific, and helped ..." [Read more]

"The editorial process for manuscript 117916 was professional and constructive. Peer review comments were relevant, specific, and helped sharpen the manuscript's clinical focus. Communication from the editorial office was clear and timely throughout submission, revision, and acceptance. We appreciate the journal's support in bringing this work on AI in onco-anaesthesia to publication. " [Collapse]

Sirohiya P, Maurya P, Gupta N, Ratre BK, Vig S, Puri S, Kumar B, Gupta R, Bhopale S, Pandit A. Artificial intelligence in onco-anaesthesia: Current applications, challenges, and future directions. World J Methodol 2026; 16(3): 117916

21807 items Read more >>

Article Quality Tracking-Peer-Review

"This study analyzed 97 HCC patients and confirmed that PIV demonstrates higher survival predictive power than ALBI or MELD-Na, ..." [Read more]

"This study analyzed 97 HCC patients and confirmed that PIV demonstrates higher survival predictive power than ALBI or MELD-Na, establishing it as an independent prognostic factor. Patients with high-PIV showed a median survival of 5 months, while those with low-PIV had a median survival of 30 months, demonstrating a significant difference. Along with ECOG, PIV emerged as the most powerful risk indicator, highlighting the prognostic value of inflammation-based biomarkers." [Collapse]

Karatlı S, Yazılıtaş D, Kaya S, İmamoğlu Gİ, Çelik S, Uyar GC. Prognostic value of pan-immune-inflammation index in hepatocellular carcinoma compared with albumin-bilirubin and model for end-stage liver disease sodium. World J Gastrointest Oncol 2026; 18(7): 121250

"This paper integrated the evaluation of considerations regarding 97 items concerning herbal medicine treatments used in colorectal ..." [Read more]

"This paper integrated the evaluation of considerations regarding 97 items concerning herbal medicine treatments used in colorectal cancer, comprehensively analyzing the reporting, methodology, and evidence levels. Regarding the explanation of the law of moderation, the herbal law indicates the effects on ORR and KPS improvement. However, since there is methodological margin in most SRs, relatively rational conclusions do not exist, and this paper proposes the value of considerate, high-quality RCTs and SRs." [Collapse]

Wang HP, Qin XY, Xu BW, Lu TC, Gao RK, Lin M, Li J. Chinese herbal medicine for colorectal cancer: An overview of systematic reviews and evidence map. World J Gastrointest Oncol 2026; 18(7): 120031

"This study developed a diagnostic scoring model to predict liver metastasis in elderly patients with lung and colorectal cancer by ..." [Read more]

"This study developed a diagnostic scoring model to predict liver metastasis in elderly patients with lung and colorectal cancer by combining four seromarkers—ST2, PIVKA-II, CEA, and CA125—with a history of fatty liver. The combination of the four markers demonstrated the highest sensitivity and specificity, and effectively predicts the likelihood of liver metastasis by classifying patients into low, medium, and high-risk groups based on their total score (0–12 points)." [Collapse]

Cheng Y, Sun YS, He YM. ST2, PIVKA-II, CEA, CA125 and their combinations in elderly liver metastases cancers: Development of a diagnostic scoring model. World J Gastrointest Oncol 2026; 18(7): 118940

"The greatest strength of this paper is that it is the first to integrate the PS-1/β-catenin/p-PTEN axis into a single invasion ..." [Read more]

"The greatest strength of this paper is that it is the first to integrate the PS-1/β-catenin/p-PTEN axis into a single invasion regulatory network. It identified a novel mechanism in which PS-1 stabilizes β-catenin and induces p-PTEN to promote gastric cancer invasion, and enhanced the reliability of the results through a multi-layered approach encompassing clinical, cell, and animal experiments. Furthermore, it expanded the potential for developing therapeutic targets by suggesting that the co-high expression of the three molecules can serve as a prognostic indicator." [Collapse]

Xiao S, Song DD, Yu YP, Xu XZ, Tang JF, Zhou CF. Novel regulatory network of PS-1/β-catenin/p-PTEN axis in gastric cancer invasion. World J Gastrointest Oncol 2026; 18(7): 118256

"The strength of this case report lies in the successful completion of curative treatment even in the extremely rare scenario of ..." [Read more]

"The strength of this case report lies in the successful completion of curative treatment even in the extremely rare scenario of ruptured liver cancer and colon invasion. After stabilization via early TAE, R0 resection was achieved through simultaneous hepatectomy and colon resection, followed by effective suppression of micrometastasis through multidisciplinary treatment utilizing TACE, lenvatinib, and tislizumab. As a result, an outstanding long-term outcome of 42 months of disease-free survival was achieved." [Collapse]

Yang CW, Zhang RX, Zheng XL, Zhu L, Zheng Z, Wu XH. Long-term survival after combined hepatectomy and colectomy for ruptured combined hepatocellular-cholangiocarcinoma with direct colonic invasion: A case report. World J Gastrointest Oncol 2026; 18(7): 118212

"The authors investigated outpatient visit frequency in 800 patients with overlapping non-erosive reflux disease and epigastric pain ..." [Read more]

"The authors investigated outpatient visit frequency in 800 patients with overlapping non-erosive reflux disease and epigastric pain syndrome and reported that frequent gastroenterology attendance was associated with disease chronicity, psychological distress, demographic characteristics, and complex medication patterns, whereas conventional measures of gastrointestinal symptom severity were not independently associated with visit frequency. However, frequent healthcare use should not automatically be interpreted as a direct surrogate for disease severity, treatment failure, or refractory acid-mediated disease. Repeated consultations may reflect interactions among symptom perception, illness-related concerns, psychological distress, previous treatment experience, healthcare accessibility, and clinician prescribing behaviour. I think that the principal clinical implication of this study is the need to move from repeated symptom-directed escalation toward multidimensional assessment of patients with overlapping upper gastrointestinal syndromes." [Collapse]

Lv M, Liu X, Huang KY, Xu LS, Che H, Yao MX, Wang FY. Outpatient visit frequency in patients with overlapping non-erosive reflux disease and epigastric pain syndrome: A multicenter study. World J Gastroenterol 2026; 32(28): 119326

"A magnetic anastomotic ring comprises: a magnetic ring , an outer shell and an inner fixing ring , wherein the outer shell can ..." [Read more]

Zhang MM, Xu SQ, Wu HX, Ren HL, Wan JH, Zhong QY, Chen MY, Zhang QF, Gong RM, Yusif-Zada K, Badarch BI, Shi AH, Lyu Y, Liu XM, Yan XP. Comparison of the anastomotic effects of combined-type and whole-type magnetic rings for gastrointestinal anastomosis in beagles. World J Gastroenterol 2026; 32(28): 118067

"This Letter to the Editor highlights the importance of monitoring ocular health as a warning sign for leukemia in pediatric patients. ..." [Read more]

"This Letter to the Editor highlights the importance of monitoring ocular health as a warning sign for leukemia in pediatric patients. It is a concise yet well-written paper, accompanied by a figure summarizing the clinical, diagnostic, and therapeutic flowchart. The references are very recent and in a sufficient number. In my opinion could be very useful for other clinicians to discover promptly leukemia. " [Collapse]

Ghosh D. Letter to the Editor: Eye as a window to disease burden in pediatric acute leukemia. World J Exp Med 2026; 16(2): 119334

"In this manuscript, the authors concluded that phytosterols are a compelling example of multifunctional dietary bioactives with ..." [Read more]

"In this manuscript, the authors concluded that phytosterols are a compelling example of multifunctional dietary bioactives with established cardiometabolic utility and prospective, albeit emerging, applications beyond lipid lowering. The authors have illustrated two figures and one table to explain their review, but Figure 1 seems unclear. The explanation of future perspectives is a good point." [Collapse]

Mohamed D, Ramadan AA, Mabrok HB, Hamed I. Phytosterols in human health: Biochemical mechanisms of action and disease-modulating effects. World J Biol Chem 2026; 17(2): 121685

"The authors reported that measured cell recovery probabilities, phenotype misclassification rates, locus- and cell-type-specific ..." [Read more]

"The authors reported that measured cell recovery probabilities, phenotype misclassification rates, locus- and cell-type-specific dropout and stutter models, quantified contamination and drop-in rates, validated minimum cell counts for consensus formation, and specified database-upload requirements should all be required for casework submission. It should also demand a clear separation of sub-source reporting and activity-level assertions. If such prerequisites are met, single-cell typing can supplement, rather than replace, bulk STR analysis and probabilistic genotyping in a small but significant number of high-value forensic instances. The manuscript is just a review, and it is so interesting." [Collapse]

Evangelou K, Angeli P, Polydorou A, Petropoulou T. Single-cell deoxyribonucleic acid typing for forensic mixtures and trace evidence: Opportunities, validation requirements, and reporting limits. World J Biol Chem 2026; 17(2): 121467

"The review clarified the HBV reactivation process. Following treatment for HBV-related HCC, the effect of immune-based methods and ..." [Read more]

"The review clarified the HBV reactivation process. Following treatment for HBV-related HCC, the effect of immune-based methods and the antivirals lamivudine, entecavir, tenofovir alafenamide, and tenofovir disoproxil fumarate on reactivation was investigated. This review suggests comparing the genome/proteome of blood from overt and relapsed HCC-related chronic HBV patients. This facilitates recognizing the lingering genetic/epigenetic profiles of HBV-resistant variants, allowing for more precise selection of the optimal antiviral treatment and eliminating the potential of viral reactivation." [Collapse]

Abdulrahman MS, Aboelmagd O, Zhang Y, Zaky S, Johar D. Precore/core mutation relatedness to viral reactivation in patients undergoing targeted therapy for hepatitis B virus-related hepatocellular carcinoma. World J Biol Chem 2026; 17(2): 120297

"The text is an excellently written mini-review that does not need methods or results. Figure 1 illustrates the significance of ..." [Read more]

"The text is an excellently written mini-review that does not need methods or results. Figure 1 illustrates the significance of TREM2-induced activation of pancreatic macrophages in obesity and its metabolic implications. However, at least one more figure is necessary to demonstrate TREM2 ligand identification and signal transduction. All references are essential, and the language is appropriate. " [Collapse]

Zhang AY, Xie CY, Song X, Guo ZH, Shi YR, Wang SY, Yang GH, Liu Y, Xu TC. Triggering receptor expressed on myeloid cells 2-driven pancreatic macrophage crosstalk: Key regulator of obesity pathophysiology and metabolic dysregulation. World J Biol Chem 2026; 17(2): 118705

" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..." [Read more]

" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied." [Collapse]

Awadallah M, Ton L, Thoguluva Chandrasekar V, Yap JEL, Vega KJ. Ascending colon toothpick impaction identified during screening colonoscopy: A case report. World J Clin Cases 2026; 14(19): 121345

"The authors Sharma and Patial, in their study entitled “Protective effects of kaempferol against diet-induced metabolic disorder," ..." [Read more]

"The authors Sharma and Patial, in their study entitled “Protective effects of kaempferol against diet-induced metabolic disorder," which was published in the World Journal of Hepatology 2026, 18(6) [1], stressed the findings of Nair et al. that kaempferol is a significant medication for diet-induced obesity and hepatic steatosis in mice[2]. This interesting study is limited in its experimental findings and focuses specifically on a diet that is restricted to Indian people. The title of the study and the abstract did not mention that this study is an experimental study or mini-review or a letter to the editor. The selection of C57BL/6 mice as an experimental model for studying the effect of kaempferol on hepatic lipids is misleading because this strain of animal is resistant to the medications, has a tendency to drink alcoholic beverages and is susceptible to morphine addiction. The authors did not mention the constituents of the Indian diet or the differences in the prevalence of MASLD between Indian people and people in other countries to claim that the Indian diet is the pathological cause for MASLD. The pharmacokinetics of kaempferol indicate that this natural antioxidant needs specific formulation to produce its effect, and there is no evidence that kaempferol reduces hepatic lipids. These points need to be considered in assessing the article to avoid many pitfalls that limit the importance of the study. References [1] Sharma V, Patial V. Protective effects of kempferol against diet-induced metabolic disorder World J Hepatol 2026; 18 (6) [2] Nair B, Gopalakrishna R, Nath LR. Kaempferol attenuates diet-induced obesity and hepatic steatosis in C57BL/6J mice fed an Indian diet mimicking regimen. World J Hepatol 2026; 18: 115659 Dr. Marwan S. Al-Nimer Emeritus Professor Department of Clinical Pharmacology and Therapeutics College of Medicine, University of Diyala, 32001 Baqubah, Iraq " [Collapse]

Sharma V, Patial V. Protective effects of kaempferol against diet-induced metabolic disorders. World J Hepatol 2026; 18(6): 120789

"Dear Authors, This study develops a rat model of chronic radiation proctitis using single-dose irradiation and follows disease ..." [Read more]

"Dear Authors, This study develops a rat model of chronic radiation proctitis using single-dose irradiation and follows disease progression with serial endoscopy, histopathology, fibrosis assessment, VEGF staining, and cytoskeletal protein analysis. The results suggest that 20–35 Gy induces persistent mucosal injury, telangiectasia, fibrosis, and chronic rectal damage, whereas lower doses allow recovery. The longitudinal endoscopic monitoring and blinded scoring increase the credibility of the model. Future studies may strengthen these findings by including fractionated irradiation protocols, validating the model in independent cohorts, and clarifying whether early α-tubulin loss is a causal mechanism or a predictive marker of chronic radiation injury." [Collapse]

Chang Y, Sun R, Juan W, Xu Z, Xu HY, Zen K, Xuan J. Establishment of a standardized rat model of chronic radiation proctitis and preliminary evaluation of its association with tubulin. World J Gastroenterol 2026; 32(26): 118923

"Dear Authors, This study investigates CDK5 expression in gastric neuroendocrine carcinoma through immunohistochemical evaluation, ..." [Read more]

"Dear Authors, This study investigates CDK5 expression in gastric neuroendocrine carcinoma through immunohistochemical evaluation, survival analysis, and functional cell-line experiments. The association of high CDK5 expression with advanced tumor features, higher Ki-67 index, poorer survival, and independent adverse prognostic value suggests a possible role of CDK5 in aggressive GNEC biology. The blinded pathological assessment and multivariable analysis enhance the credibility of the results. The conclusions could be further strengthened by validation in larger multicenter cohorts and by additional pathway-level studies explaining the biological basis of CDK5 activity, particularly the different effects observed in knockdown and overexpression experiments. These future approaches may clarify whether CDK5 serves only as a prognostic marker or may also represent a therapeutic target in GNEC." [Collapse]

Sun YQ, Su J, Ye KN, Chen QX, Kang EZ, Lv CB, Lian MQ, Zeng WM, Zhang YB, Cai LS. High cyclin-dependent kinase 5 expression promotes tumor progression in gastric neuroendocrine carcinoma. World J Gastroenterol 2026; 32(26): 119574

"Fragos et al. presented a case on CSS with hypothyroidism and dyslipidemia. Such a rare case is very important for clinical practice. ..." [Read more]

"Fragos et al. presented a case on CSS with hypothyroidism and dyslipidemia. Such a rare case is very important for clinical practice. The case report is presented according to CHECK criteria, thoroughly and well-documented. The content is easily readable and clear, English is correct. The discussion is fruitful, the conclusions have arisen from the presented text. The future perspective are presented. The references are updated. " [Collapse]

Fragos MN, Toulia I, Grammatikopoulou MG, Savvidou P, Taiganidis I, Zissiadis P, Antachopoulos C, Goulis DG, Tsiroukidou K. De novo ARID1A Coffin-Siris syndrome with hypothyroidism and dyslipidemia: A case report and literature review. World J Clin Cases 2026; 14(19): 120716

"This retrospective study addresses a clinically relevant question—whether long-term outcomes after endoscopic strictuotomy for small ..." [Read more]

"This retrospective study addresses a clinically relevant question—whether long-term outcomes after endoscopic strictuotomy for small bowel strictures differ by etiology and whether a simple biomarker can aid risk stratification. The scientific quality is above average, with several methodological strengths, though important limitations temper the conclusions. 1. The study fully meets ethical standards, with IRB approval and informed consent documented. The methodology is clearly described and reproducible, including well-defined eligibility criteria, a patient flowchart, and detailed procedural specifications. However, key unresolved issues weaken internal validity: the lack of standardized post-procedural medical therapy (especially biologics in Crohn's patients) introduces a major confounder; strictures were classified as fibrosis-dominant based on imaging and endoscopy alone without histopathological confirmation; and reintervention decisions relied on symptom recurrence rather than a validated scoring system, introducing subjectivity. 2. The results are authentic and statistically robust. Tables and figures are well-constructed, though endoscopic images could benefit from annotations. Statistical methods are rigorous: a parsimonious multivariable Cox model avoided overfitting, maximally selected log-rank statistics objectively determined the NLR cutoff, and collinearity was properly managed. Nonetheless, gaps remain—no formal power calculation, no sensitivity analyses, and no interaction test between etiology and NLR to assess whether the biomarker's prognostic value differs between groups. 3. References are comprehensive, current, and relevant. 4. The authors have honestly acknowledged several limitations, including the single-center design, modest sample size, residual confounding, and subjective outcome definition. However, other critical issues remain unresolved: heterogeneity within the non-Crohn's group (radiation, NSAID, ischemic, CMUSE) is unexplored; histopathological fibrosis confirmation is lacking; post-procedural medical protocols are not standardized; and only baseline NLR was assessed. To address these gaps, future studies should incorporate objective fibrosis assessment (EUS, CLE, or STAR histopathological scoring), enroll larger cohorts for subgroup analyses and interaction testing, use validated symptom scores for reintervention definition, and measure NLR longitudinally. A formal sample size calculation based on the effect sizes observed here would strengthen future prospective, multicenter study designs. In summary, this study makes a valuable contribution by providing etiology-stratified outcome data and identifying NLR as a practical prognostic marker. The findings suggest that non-Crohn's patients with low NLR are the best candidates for endoscopic strictuotomy, while Crohn's patients with elevated NLR may need intensified medical therapy or earlier surgery. Despite its limitations, the study is methodologically sound and advances the field. " [Collapse]

Lai WC, Feng XM, Huang ZH, Jiang ZM, Sun T, Yin X, Zhang L, Ning SB, Li BR. Balloon-assisted endoscopic stricturotomy for small bowel fibrostenotic strictures: A comparison of Crohn’s disease-related and non-Crohn’s disease strictures. World J Gastroenterol 2026; 32(26): 118889

"Colorectal cancer (CRC) is currently one of the most important causes of morbidity and mortality in all parts of the world. It is ..." [Read more]

"Colorectal cancer (CRC) is currently one of the most important causes of morbidity and mortality in all parts of the world. It is very important that the shift in its occurrence to younger ages concerns not only developed but also developing countries. According to other epidemiological data, the incidence of this neoplasm is expected to increase over the next two decades despite the availability of the most effective treatment methods. Preventive screening of the asymptomatic population, aimed at early detection, remains the cornerstone of efforts to increase five-year survival rates. Although in all developed countries preventive screening programs are implemented with varying effectiveness, mainly through colonoscopy, the situation is different in developing countries. The limited resources available for health promotion, socioeconomic disparities, and other factors necessitate the development of a cost-effective screening program tailored to these specific conditions. In these countries, priority should be given to primary screening methods, such as fecal hemoglobin detection, which, if positive, should be followed by colonoscopy. The identification of high-risk groups for mandatory colonoscopy is imperative, in combination with efforts to reduce the influence of other environmental factors (mainly dietary) on carcinogenesis. The review by Wu et al. emphasizes the need to develop optimized risk-stratification algorithms in these countries, as an adaptive, organized screening framework can deliver optimal population-level benefits while increasing residents' willingness to undergo colonoscopy." [Collapse]

Wu YP, Chen M, Wang L. Current colorectal cancer screening in developing countries: Identifying optimal approaches. World J Gastroenterol 2026; 32(26): 118151

"This is a well-written and prezented rarely case report about " Pancreatic Schwannoma". Schwannoma can occur anywhere in the body. ..." [Read more]

"This is a well-written and prezented rarely case report about " Pancreatic Schwannoma". Schwannoma can occur anywhere in the body. Pancreatic schwannoma (PS) is an extremly rare mesenchymal tumor. Technological advancements in cross-sectional imaging such as ultrasonography (USG), computed tomography (CT), and magnetic resonance imaging (MRI), and their increased use have made incidental pancreatic tumors more frequently detectable. Pancreatic schwannoma is one of these tumors and should be considered in the differential diagnosis. This manuscript gives additional new knowledge to the existing literature. I think that this manuscript is suitable and worth to be published in the World Journal of Gastrointestinal Surgery." [Collapse]

Xu SM, Qiu LY. Incidental schwannoma of the pancreatic tail mimicking a solid pseudopapillary tumor: A case report. World J Gastrointest Surg 2026; 18(6): 119246

16062 items Read more >>

Peer-Reviewers and Manuscript Statistics

Editorial board members: 2262

Peer-reviewers: 38641

Manuscripts received today: 30

Manuscript reviews today: 57

Unhandled manuscripts today: 172

Active peer-reviewers today: 2129

Reviewer acceptance today: 86

Reviewer refusals today: 110

Total accepted manuscripts: 42095

Total rejected manuscripts: 46415

Total peer-reviewers: 4998562

Total submissions: 39928

Baishideng Publishing Group (BPG) publishes 47 peer-reviewed, open-access journals covering a broad range of topics in clinical medicine, as well as several topics in biochemistry and molecular biology, relevant to human health today.

BPG Journal List

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All Journal Articles

Lorente L, Hernández Marrero E, Abreu-Gonzalez P, Lorente Martín AD, Lorente Martín M, Marrero González MJ, Hernández Marrero C, Hernández Marrero O, Jiménez A, Hernández Padilla CM. Salivary glutathione peroxidase-1 levels in periodontitis. World J Methodol 2026; 16(3): 121596

2026-09-20 | Browse: 177 | Download: 78

Wang P, Sun JK, Li D, Shi Z, Lu PY, Jin DF, Huang SF, Ruan YH, Li WT, Shi MD, Ma ZH, Wang ZH, Hu LY, Xue ME, Zhang CJ, Li ZP. Precision management of gastrointestinal tumor-associated osteoporosis driven by cutting-edge technologies: Current status, challenges, and future prospects. World J Methodol 2026; 16(3): 121456

2026-09-20 | Browse: 292 | Download: 66

Carioti G, Brighenti I, Le Donne N, Banfi C, Azzahrani L, Galassi L. Clinical assessment of nail and skin lesions in indoor climbers: A clinic-based cross-sectional study. World J Methodol 2026; 16(3): 121149

2026-09-20 | Browse: 182 | Download: 79

Usta Küçükbezirci G, Gürcan B, Patel N, Ramsey DJ, Alwreikat A. Standardizing the Yamane flanged intrascleral haptic fixation: A framework for efficacy, complication mitigation, and reproducible training. World J Methodol 2026; 16(3): 120949

2026-09-20 | Browse: 170 | Download: 71

Prakash HS, Sehrawat A, Rana A, Swamy AM, Prasath S, Koulagi M, Sundriyal D. Translation of the strength, assistance in walking, rising from a chair, climbing stairs, and falls questionnaire into Hindi. World J Methodol 2026; 16(3): 120002

2026-09-20 | Browse: 213 | Download: 97

Mirghani HO, AlQurashi AM. Glucagon-like receptor-1 agonists and impotence: A meta-analysis. World J Methodol 2026; 16(3): 119385

2026-09-20 | Browse: 163 | Download: 63

Zou CL. Letter to the Editor: Revisiting salt restriction in hyponatremic cirrhosis - a paradigm in need of refinement? World J Methodol 2026; 16(3): 118971

2026-09-20 | Browse: 126 | Download: 52

Pan HY, Chen WW, Liang JX, Sheng YY, Zhang WJ, Zhu XW, Wang SY, Yang GH, Liu Y, Xu TC. Pancreatic-liver crosstalk, novel molecular mediators, and 2025 therapeutic breakthroughs. World J Methodol 2026; 16(3): 118728

2026-09-20 | Browse: 158 | Download: 60

Khullar S, Morya AK, Aggarwal S, Singh A, Sisodiya P, Morya R. Anti-obesity medications impacting the eye: An emerging concern - a narrative review. World J Methodol 2026; 16(3): 118520

2026-09-20 | Browse: 262 | Download: 63

Goyal MK, Brahmandam G, Chowdhary R, Subhasri Guna SD, Shah D, Goyal P, Vuthaluru AR, Goyal O. Management of constipation: A narrative review of evolving strategies and methodological challenges. World J Methodol 2026; 16(3): 118399

2026-09-20 | Browse: 199 | Download: 55

Zhuang SY, Xu LJ, Yang HX, Yang QW, Chen G, Xu B, Yu Z, Liu Y, Xu TC. Pancreatic nerves across species: Anatomical and functional disparities and their metabolic ramifications. World J Methodol 2026; 16(3): 118207

2026-09-20 | Browse: 259 | Download: 47

Garcia R, English K. Doctor of osteopathic medicine degree still faces recognition challenges in the United States: Suggested ways to improve awareness. World J Methodol 2026; 16(3): 118145

2026-09-20 | Browse: 172 | Download: 66

2026-09-20 | Browse: 147 | Download: 54

Maan MHA, Maan S, Waleed M, Ahmad MM, Goyal RM, Sohail AH, Abboud Y, Khan S, Gayam S, Kupec J. Functional dyspepsia and risk of Barrett’s esophagus and dysplasia: A propensity-matched multicenter retrospective cohort study. World J Methodol 2026; 16(3): 117891

2026-09-20 | Browse: 160 | Download: 76

Méndez-Toro A, Rojas-Ruiz IT, Silva-DiazGranados LE, Ruano-Cadena A, Paz-Meneses MA, Novoa-Alvarez RA. Prognostic impact of right ventricular dilatation and echocardiography use criteria in hospitalized COVID-19 patients. World J Methodol 2026; 16(3): 117845

2026-09-20 | Browse: 161 | Download: 74

Mahamid A. Surgical paradox: Pen vs scalpel-an opinion review on reforming academic promotion. World J Methodol 2026; 16(3): 117516

2026-09-20 | Browse: 121 | Download: 49

Manian S, Gunasekar A, Jeyaraman N, Nallakumarasamy A, Muthu S, Jeyaraman M. Fragility fracture risk prediction using quantitative magnetic resonance and Vertebral Bone Quality scoring beyond density. World J Methodol 2026; 16(3): 117490

2026-09-20 | Browse: 124 | Download: 50

2026-09-20 | Browse: 189 | Download: 92

Farhan M, Patel T, Harazeen W, Mohamed Y, Al Azzawi A, Intabli H, Ahmed N, Obais MAHN, Alkhazali MR, Patel BD, Ahmad A, Awosika A. Smartphone-based mobile health impact on oral anticoagulation adherence, quality of life, and healthcare utilization in adult atrial fibrillation. World J Methodol 2026; 16(3): 117065

2026-09-20 | Browse: 147 | Download: 65

Wu XJ, Tang JY, Sun NZ. Letter to the Editor: Low-energy fractional carbon dioxide laser priming of mesenchymal stem cell-derived exosomes: A photothermal boost for diabetic wound angiogenesis. World J Methodol 2026; 16(3): 116914

2026-09-20 | Browse: 115 | Download: 53

64062 items Read more >>

Featured Articles

Zhou DX, Jiang SW, Zhang CG, Cai BJ, Lv HD. Perioperative SOX plus sintilimab vs P-SOX and CAPOX in advanced gastric cancer: A real-world comparison. World J Gastroenterol 2026; 32(29): 119809

2026-07-17 | Browse: 6 | Download: 21

Zhang JQ, Yin L, Zhu YJ, Dong L, Hou CL, Tian SJ, Chen P, Huang X, Xu H, Chen ZY, Xu XJ, Zhou CZ, Cheng DL. Modified model incorporating sarcopenia and myosteatosis for predicting severe hepatic encephalopathy after transjugular intrahepatic portosystemic shunt: Multicenter study. World J Gastroenterol 2026; 32(29): 118090

2026-07-17 | Browse: 5 | Download: 14

Peltec A, Sporea I. Preventive strategies in hepatology: Role of multiparametric assessment of portal hypertension in chronic liver disease. World J Gastroenterol 2026; 32(29): 119106

2026-07-17 | Browse: 5 | Download: 9

Yao QH, Yang WY. Extending the evidence on ustekinumab safety in Crohn’s disease: A pharmacovigilance disproportionality analysis of FAERS data. World J Gastroenterol 2026; 32(29): 120684

2026-07-17 | Browse: 4 | Download: 5

Maestri M, Cicerone O. Small tumors, big decisions: Rethinking resection and ablation in early hepatocellular carcinoma. World J Gastroenterol 2026; 32(29): 116653

2026-07-17 | Browse: 6 | Download: 12

Por CLS, Shelat VG. Letter to the Editor: Adverse event classification in gastrointestinal endoscopy. World J Gastrointest Endosc 2026; 18(7): 120239

2026-07-16 | Browse: 9 | Download: 3

Li W, Xiao M, Wu DD, Zhang KG, Ye C. Stump appendicolith removal using a pancreaticobiliary scope in an elderly patient: A case report. World J Gastrointest Endosc 2026; 18(7): 121212

2026-07-16 | Browse: 7 | Download: 11

2026-07-16 | Browse: 7 | Download: 17

Çakmak FM, Aydınlı H, Özkan A, Haznedaroglu IC, Simsek C. Ankaferd blood stopper application in gastrointestinal bleeding: An updated narrative review. World J Gastrointest Endosc 2026; 18(7): 121964

2026-07-16 | Browse: 11 | Download: 21

Shrestha UK. Mitigating challenges in endoscopic management of post-liver transplant biliary strictures. World J Gastrointest Endosc 2026; 18(7): 123520

2026-07-16 | Browse: 8 | Download: 6

Shrestha UK. Preventive strategies for complications after endoscopic ultrasound-guided fine-needle biopsy. World J Gastrointest Endosc 2026; 18(7): 119987

2026-07-16 | Browse: 5 | Download: 18

Morgan A, Zhu A, Hannah N, Haridy J, Raj A, Bhala N. Hepatocellular carcinoma in patients without cirrhosis: Urgent need to include Australasian populations. World J Gastroenterol 2026; 32(28): 117785

2026-07-14 | Browse: 47 | Download: 50

Mei J, Jin YD, Xie YC, Huang PP, Deng Y, Chen Y. Timeliness-incentive home health management for metabolic dysfunction-associated steatotic liver disease. World J Gastroenterol 2026; 32(28): 119134

2026-07-14 | Browse: 37 | Download: 49

2026-07-14 | Browse: 29 | Download: 56

Nguyen CD, Dang LM. Biosimilars in inflammatory bowel disease: Beyond evidence, toward trust and implementation. World J Gastroenterol 2026; 32(28): 119462

2026-07-14 | Browse: 29 | Download: 42

2026-07-14 | Browse: 32 | Download: 52

Lizzi L, Massimi M. Letter to the Editor: Tumor necrosis factor-α signaling and β-cell apoptosis in acute pancreatitis - integrating molecular mechanisms and metabolic implications. World J Gastroenterol 2026; 32(27): 117268

2026-07-14 | Browse: 29 | Download: 41

Zhang S, Wang SH, Zhao YD, Wei JH, Sui XY, Li X, Zhang HW, Huang ZY, Wang CL, Hu H, Zhang J, Li ZS, Zhao SB, Bai Y. Performance of computer-aided diagnosis for colorectal sessile serrated lesions: A systematic review and meta-analysis. World J Gastroenterol 2026; 32(27): 118009

2026-07-14 | Browse: 28 | Download: 64

Hu SP, Cai YR, Liu Y, Guo YX, Jia XM, Jiang JM, Yang Q. Hua-Zhuo-Jie-Du formula alleviates colitis-associated colorectal cancer via regulating phosphatidylinositol 3-kinase/protein kinase B signaling pathway. World J Gastroenterol 2026; 32(27): 119490

2026-07-14 | Browse: 32 | Download: 53

Zhang Y, Zhou YL, Nie X, Zhang LJ, Xu WW, Wang JQ, Zhao HL, Xu JK, Xu J, Xu HM, Li JH, Huang WQ, Yang J, Yang YX, Zhan Q, Lin Y, Nie YQ. Gram-negative bacteria and endotoxins promote hepatocellular carcinoma progression through the recruitment of myeloid-derived suppressor cells. World J Gastroenterol 2026; 32(27): 118794

2026-07-14 | Browse: 29 | Download: 40

10981 items Read more >>

Keyword Search Published Articles Processes

Case report

4762

Hepatocellular carcinoma

1802

Gastric cancer

1323

Colorectal cancer

1295

Prognosis

1095

Inflammatory bowel disease

873

COVID-19

848

Treatment

778

Diagnosis

761

Liver transplantation

756

Ulcerative colitis

702

Meta-analysis

677

Crohn’s disease

630

Endoscopy

625

Cirrhosis

621

Inflammation

605

Helicobacter pylori

604

Magnetic resonance imaging

589

Surgery

562

Pancreatic cancer

525

72057 items Read more >>

Reader Comments

"I am very grateful for the opportunity to write this reader comment. Ulcerative colitis (UC) remains a clinical challenge. ..." [Read more]

"I am very grateful for the opportunity to write this reader comment. Ulcerative colitis (UC) remains a clinical challenge. Conventional therapeutic regimens offer only limited benefit. Although stem cell therapy has emerged as a promising alternative, its efficacy is substantially restricted by the inefficient homing of bone marrow‑derived mesenchymal stem cells (BMSCs) to the inflamed colonic mucosa. In the present study, Gong et al. designed both in vitro and in vivo experiments. They investigated whether Tongxie Yaofang (TXYF) modulates BMSC homing in a colitis model. They also sought to dissect the specific molecular mechanisms involved. The therapeutic efficacy of combined TXYF and BMSC intervention was evaluated through macroscopic, microscopic, structural, and functional indicators. This is a well‑conducted study. The background is logically presented with reference to relatively recent literature. The experimental design is comprehensive and innovative, and the chain of evidence is largely complete. The methodology is described in sufficient detail to ensure good reproducibility. The discussion section offers a reasonable interpretation of the results. It draws effective comparisons with previous studies and highlights the clinical significance of the findings. The authors also employ accurate and appropriate professional terminology throughout. The authors note three main limitations. First, they did not perform chemical quality control for the TXYF formulation. Second, they were unable to track the long‑term survival and differentiation of BMSCs after homing. Third, other signalling pathways beyond SDF‑1/CXCR4 may also contribute to the observed pro‑homing effect, given the multicomponent nature of the herbal formula. " [Collapse]

Gong SS, Li ML, Liu L, Lv B. Tongxie Yaofang enhances the homing efficiency of exogenous bone marrow-derived mesenchymal stem cells to the colonic mucosa and alleviates ulcerative colitis. World J Stem Cells 2026; 18(6): 119228

"Reader expertise gastrointestinal oncology Conflicts-of-interest statement The reviewer declares no conflict of interest. Scientific ..." [Read more]

"Reader expertise gastrointestinal oncology Conflicts-of-interest statement The reviewer declares no conflict of interest. Scientific quality Grade A Language quality Grade A Reader comments I would like to congratulate the authors on publishing this interesting and clinically valuable case report. The manuscript presents a rare case of rectal perforation manifesting as extensive subcutaneous emphysema, which provides important insights for clinical practice. This article is well organized, clearly written, and supported by high-quality imaging and intraoperative findings. One of the major strengths of this report is its emphasis on the atypical clinical presentation in elderly patients, particularly in the absence of classic signs of peritonitis. This finding offers valuable diagnostic guidance for surgeons, emergency physicians, and clinicians involved in the management of acute abdominal conditions.In addition, the literature review further strengthens the clinical value of this manuscript by summarizing previously reported non-endoscopic cases and highlighting the rarity of this condition. The discussion regarding the potential anatomical pathways of gas dissemination from rectal perforation to subcutaneous tissues is also informative and helps improve understanding of the underlying disease mechanism. A minor suggestion would be to further expand the discussion on the differential diagnosis of unexplained subcutaneous emphysema in elderly patients, as well as the clinical decision-making process for early diagnosis and surgical intervention. This may further enhance the educational and practical value of the report. Overall, this is a well-written, informative, and meaningful case report with important clinical implications. It contributes valuable evidence for improving the early recognition and timely management of atypical rectal perforation. " [Collapse]

Sun YT, Wang XW, Mongardini FM, Ling LM, Ma LA, Xiao Q. Subcutaneous emphysema due to rectal perforation: A case report. World J Gastrointest Surg 2026; 18(6): 119045

"I would like to commend the authors for conducting this well-designed multicenter randomized controlled trial addressing an important ..." [Read more]

"I would like to commend the authors for conducting this well-designed multicenter randomized controlled trial addressing an important clinical question in endoscopic management of flat colorectal polyps. The modified cold snare polypectomy (CSP) technique, which employs suction-assisted elevation to create a pseudopolyp, represents an innovative technical refinement that directly targets the common problem of snare slippage during resection of Paris classification 0-IIa lesions. This study is clinically relevant as flat polyps are frequently encountered in routine colonoscopy practice, and incomplete en bloc resection remains a significant concern given its established association with post-colonoscopy colorectal cancer. The concept of suction-induced pseudopolyp formation is biomechanically elegant; by generating a three-dimensional morphology with a well-defined stalk, the modified technique enhances mechanical interlock between the snare wire and tissue, thereby reducing lateral slippage during closure. Furthermore, the favorable safety profile observed in both groups—specifically the absence of delayed bleeding or perforation—is reassuring and consistent with existing CSP literature, supporting the outpatient applicability of this approach. The authors are also to be applauded for their transparency in acknowledging several methodological limitations, including the lack of histologic margin confirmation and the absence of surveillance colonoscopy to assess long-term recurrence, which reflects scientific integrity. Areas for improvement and considerations: Clustering by patient: The authors acknowledge that multiple polyps from individual patients were analyzed at the polyp level without accounting for within-patient correlation. While they cite limited sample size as justification, this remains a methodological concern. The use of generalized estimating equations or mixed-effects models, even with modest clustering, would have strengthened the statistical robustness of the findings. Lack of clinical trial registration: The statement that the study was not registered because it was "not standard departmental practice for internally initiated, therapeutic studies of this scale and nature" is concerning. Given that this is a randomized controlled trial conducted from January 2023 to June 2025—well after the establishment of mandatory trial registration norms—prospective registration should have been undertaken. This omission may affect the credibility and reproducibility of the findings. Endoscopic vs. histologic complete resection: The study reports a 100% endoscopic complete resection rate in both groups, yet acknowledges that histologic confirmation of margins was not available due to tissue fragmentation inherent to CSP. This creates a potential detection bias, as endoscopic assessment alone may overestimate true complete resection. The discrepancy with Shinozaki et al.'s meta-analysis (6.0% incomplete resection rate with CSP) warrants further investigation, and the authors' explanation, while plausible, does not fully resolve this concern. Long-term outcomes: The absence of surveillance colonoscopy data limits the clinical impact assessment. A higher en bloc resection rate is meaningful only if it translates into reduced recurrence and post-colonoscopy colorectal cancer. I would encourage the authors to report follow-up data in a subsequent study. Subgroup analysis: Given that all non-en bloc resections occurred in 7-9mm polyps, a more detailed subgroup analysis by polyp size (5-6mm vs. 7-9mm) would be informative. This could help identify the optimal size threshold for applying the modified technique. For future investigations, the authors are encouraged to incorporate histologic margin assessment where feasible, or alternatively utilize advanced imaging modalities such as confocal laser endomicroscopy or optical coherence tomography to validate complete resection. Additionally, a prospective cohort study with scheduled surveillance colonoscopy at 6-12 months would be valuable to evaluate recurrence rates, and a comparative study between the modified CSP and other emerging techniques—such as underwater EMR or cold endoscopic mucosal resection—for flat polyps in the 5-9mm range would further clarify the relative advantages of this approach. This study makes a meaningful contribution to the endoscopic management of flat colorectal polyps. The modified CSP technique is technically sound and the results are promising. However, the methodological limitations—particularly the lack of trial registration, the polyp-level analysis without patient-level clustering adjustment, and the absence of long-term follow-up—moderate the strength of the conclusions. I encourage the authors to address these issues in future work to fully establish the clinical value of this innovative technique. " [Collapse]

Chen JH, Chen MM, Zhang Y, Lin LL, Huang R, Tang FN, Lin RQ, Chen SY. Effectiveness and safety of modified cold snare polypectomy for flat colorectal polyps: A multicenter randomized controlled trial. World J Gastrointest Surg 2026; 18(6): 119157

"This is a well-designed and clinically meaningful study with appropriate statistical methods and generally clear presentation. The ..." [Read more]

"This is a well-designed and clinically meaningful study with appropriate statistical methods and generally clear presentation. The comparison of baseline HbA1c, time-weighted average HbA1c, and glycemic trajectories provides useful insights into diabetic kidney disease risk. It may be helpful for the authors to provide a little more detail regarding how the HbA1c threshold of approximately 7.0% was identified and validated. " [Collapse]

Zou HY, Jiang H, Guo XD, Wen ZY, Shi Y, Zhou AD, Wang MM, Xu F, Cai MY. Dynamic glycemic exposure and trajectory profiling for incident diabetic kidney disease: A longitudinal cohort study. World J Diabetes 2026; 17(6): 120343

"On serial HbA1c variability and CGM-derived indicators in cardiovascular risk assessment in diabetes mellitus Yi Wang1, Guoliang ..." [Read more]

Ganakumar V, Fernandez CJ, Pappachan JM. Glucagon-like peptide-1 receptor agonists in type 2 diabetes: Evidence for disease modification and therapeutic switching. World J Diabetes 2026; 17(6): 116477

"This review provides a timely and clinically relevant discussion on the evolving role of HbA1c in cardiovascular risk assessment among ..." [Read more]

"This review provides a timely and clinically relevant discussion on the evolving role of HbA1c in cardiovascular risk assessment among patients with diabetes mellitus. The article appropriately emphasizes that HbA1c remains an important marker of long-term glycemic exposure, but should not be interpreted as the sole determinant of cardiovascular risk. In particular, the discussion of HbA1c variability, individualized glycemic targets, and the cardiovascular benefits of SGLT2 inhibitors and GLP-1 receptor agonists highlights the need to move beyond a glucose-centric framework. From a clinical perspective, cardiovascular risk in diabetes should be assessed through an integrated approach that considers glycemic burden, glycemic variability, hypoglycemia risk, renal function, obesity, blood pressure, lipid profile, and established cardiovascular disease. This perspective is important because intensive HbA1c reduction may not uniformly translate into cardiovascular benefit across different patient populations, especially in those with long-standing diabetes or multiple comorbidities. Overall, the article offers a balanced and meaningful interpretation of current evidence and supports a more individualized, outcome-oriented strategy for diabetes managemen. " [Collapse]

Goyal MK, Hatwal J, Desai R, Sehgal T, Batta A. Glycated hemoglobin and cardiovascular risk in diabetes mellitus: Evolving evidence beyond glycemic control. World J Diabetes 2026; 17(6): 115820

"This retrospective study by Jie et al. provides a clinically valuable and methodologically sound nomogram for perioperative risk ..." [Read more]

"This retrospective study by Jie et al. provides a clinically valuable and methodologically sound nomogram for perioperative risk stratification in HBV-related HCC patients undergoing TACE. Its three predictors (Child-Pugh stage, number of TACE sessions, and HBV DNA load) are clinically accessible, well-validated across sensitivity models, and easy to apply at the bedside. Notably, these same predictors directly overlap with liver transplantation eligibility parameters, a critical dimension absent from the original analysis. In patients being bridged to transplantation, post-TACE acute liver injury can meaningfully affect MELD trajectory, accelerate waitlist dropout, and ultimately compromise transplant eligibility. The absence of systematic antiviral therapy data represents an important limitation, as effective HBV suppression may directly reduce acute liver injury risk and alter hepatocyte vulnerability to TACE-related injury. Future multicenter prospective validation cohorts should incorporate transplant-oriented endpoints and systematic antiviral therapy data, and consider yttrium-90 radioembolization as an alternative bridging strategy for patients identified as high-risk by this nomogram. " [Collapse]

Jie XH, Xi DY, Zhang SS, Yan XB. Acute liver injury after transcatheter arterial chemoembolization in patients with hepatitis B virus-related intermediate or advanced hepatocellular carcinoma stages. World J Gastroenterol 2026; 32(24): 118709

"We would like to add a small supplementary perspective. Given the obvious differences in DR pathological features among MODY, LADA ..." [Read more]

"We would like to add a small supplementary perspective. Given the obvious differences in DR pathological features among MODY, LADA and ketosis-prone diabetes in real clinical practice, it is necessary to formulate phenotype-specific screening intervals and intervention strategies, instead of applying unified protocols for all diabetic patients. For instance, patients with glucokinase-MODY have a significantly lower DR risk than those with HNF1A-MODY due to milder chronic hyperglycemia, supporting the need for stratified follow-up intervals. Meanwhile, more large-sample longitudinal studies are still required to clarify the long-term DR progression rules of atypical diabetes phenotypes. In conclusion, this is a comprehensive and practical review. It deepens our understanding of DR heterogeneity and will help optimize the whole-process management of diabetic eye complications. " [Collapse]

Rastogi A, Khamesra A. Prevalence of diabetic retinopathy across different diabetes phenotypes. World J Diabetes 2026; 17(6): 119328

"This multicenter post hoc analysis of the RELAPSTONE cohort focused on a special patient group. Symptomatic gallstone disease (SGD) ..." [Read more]

"This multicenter post hoc analysis of the RELAPSTONE cohort focused on a special patient group. Symptomatic gallstone disease (SGD) recurs in patients aged ≥80 years who are not operated on at the index admission. Its principal strengths are the large size. It has reportedly the largest cohort of patients ≥80 years with SGD. It also has a multicenter design, and has a contemporary age threshold (80 year) that reflects current life expectancy better than the conventional cutoff of 65. The observation that recurrences in the elderly are fewer but later and more severe, with acute cholecystitis most common, is clinically useful and clearly presented. My suggestions which aim to improve this and other such studies are as follows. First, death is an important competing event for recurrence and is considerably more frequent in the ≥80 group, yet the study was analysed with standard Kaplan–Meier and Cox models. Patients who die can no longer experience a recurrence, and mortality differs substantially between groups. Cumulative incidence function for recurrence with death as a competing event combined with Fine–Gray subdistribution hazards would yield a more accurate estimate of the actual probability of recurrence in each age group. Reporting the proportions censored because of death and end of follow-up would also clarify the analysis. Second, the molecular mechanism underlying SGD warrant further study and elucidation. Whereas elderly people recur in a more severe manner, their overall state and comorbidity limit the use of cholecystectomy. Developing oral or transfusion drugs would benefit this group of patient who are more often influenced by worse symptoms. Overall this is a valuable contribution that should help refine risk stratification in an important and growing population, and the comments above are intended to strengthen an already solid study. " [Collapse]

Oyón D, Velamazán R, Arnau A, López-Guillén P, Martínez-Domínguez SJ, Abad Baroja D, Ruiz-Belmonte LM, Tejedor-Tejada J, Zapater R, Martín-Vicente N, Julián Gomara AB, Sastre Lozano V, Manzanares García JJ, Cañamares-Orbis P, García-Rayado G, Millastre Bocos J, Garcia de Paredes AG, Vaamonde Lorenzo M, Izagirre Arostegi A, Sirtl S, de-Madaria E. Recurrence patterns and outcomes of symptomatic gallstone disease in the elderly. World J Gastroenterol 2026; 32(21): 117971

"Clarifying Survival Estimates After Adrenal Metastasectomy Following Liver Transplantation for Hepatocellular Carcinoma Manuscript ..." [Read more]

Ramia JM, Franco M, Alcázar C, Carbonell-Morote S, Rubio-García JJ, Rodríguez M, Pascual S, Melgar P, Villodre Tudela C. Adrenal metastasis of hepatocellular carcinoma after liver transplantation: Case report and systematic review of literature. World J Transplant 2026; 16(2): 116999

"Cell-cell fusion is a fundamental process during development, tissue regeneration, or reconstruction. This review extended this ..." [Read more]

"Cell-cell fusion is a fundamental process during development, tissue regeneration, or reconstruction. This review extended this concept, and the authors discussed the pros and cons of stem cell fusion. Overall, it is a concise and timely review. Since cell-cell fusion is a conserved phenomenon during the development of most organisms, it would be beneficial to introduce eukaryotic fusogens in the nematode Caenorhabditis elegans, the Fusion Family (FF) proteins, which are responsible for fusing approximately one-third of all somatic cells during development. In addition, macrophage fusion can result in the formation of osteoclasts or multinucleated giant cells; the latter one should be discussed in the paper. In the section “STEM CELL-DRIVEN CELL FUSION IN INJURED TISSUES”, it is better to specify the kind of stem cells used in each cited study. For example, BMDCs, HSCs, CD34+ progenitors, and MSCs are mentioned in different studies of cell fusion in the heart, whereas the authors simply refer to them as stem cells. " [Collapse]

Kim JS, Hwang IS, Kim SJ, Moon MH, Park HD, Jin BH, Kim DY, Lee MJ, Eum SY, Yoo SJ, Cha BH. Cell-cell fusion and stem cell plasticity: Emerging paradigms in tissue regeneration. World J Stem Cells 2026; 18(5): 118307

"Dear Editor, We carefully reviewed the recent study by Li et al. published in the World Journal of Gastroenterology and reflected ..." [Read more]

"Dear Editor, We carefully reviewed the recent study by Li et al. published in the World Journal of Gastroenterology and reflected on its potential clinical implications. The study innovatively demonstrated that salidroside can attenuate intestinal inflammation and promote mucosal repair by activating the cAMP/PKA/CREB signaling pathway and suppressing the abnormal activation of enteric glial cells. These findings suggest that the pathogenesis of ulcerative colitis may involve not only conventional immune-inflammatory dysregulation but also dysfunction of the neuro–glia–immune regulatory network.Given the persistent clinical challenges in UC management, including limited long-term therapeutic efficacy, high relapse rates, and treatment-related adverse effects, the development of multitarget therapeutic strategies with anti-inflammatory, mucosal-protective, and neuroimmune-modulating properties is of considerable importance. In light of these findings, further studies may focus on the current therapeutic landscape of UC, systematically evaluating the pharmacological characteristics and potential clinical value of salidroside. Moreover, exploring its mechanisms of action and translational potential from the perspective of neuro-glia-immune regulation may provide novel insights into the pathogenesis of UC and contribute to the development of more effective therapeutic strategies. " [Collapse]

Li Y, Tao SS, Wang Y, Sun Q, Li MY, Zhang H, Li YQ. Salidroside mitigates experimental colitis through cyclic adenosine monophosphate pathway activation and suppression of enteric glial cell responses. World J Gastroenterol 2026; 32(21): 116337

"As a pathologist, I find this study directly addresses the familiar disconnect between endoscopic biopsy and surgical resection—a ..." [Read more]

"As a pathologist, I find this study directly addresses the familiar disconnect between endoscopic biopsy and surgical resection—a discrepancy rooted in sampling bias rather than diagnostic error. The AI-assisted system compensates for this by guiding targeted biopsies: 95.1% of the detection gain came from precise recognition and localization of subtle lesions, not from simply taking more biopsies. The rigorous double-reading with blinded pathology review strongly supports the findings. Grouping low-grade, high-grade intraepithelial neoplasia, and early gastric cancer as endpoints is clinically pragmatic, and the marked AI advantage at blind spots like the gastric angle aligns with everyday practice. To deepen the evidence, future work could add positive predictive value, compare biopsy-to-surgery upgrade rates between groups, and characterize the pathology of false-positive AI detections (e.g., reactive changes). Correlating endoscopic morphology with histopathology would further transform AI from a detection tool into a diagnostic aid. Overall, this high-quality study offers a promising means to reduce sampling error and bridge the gap between endoscopic detection and pathological confirmation. " [Collapse]

Ying JX, Yan SY, Fu XY, Zhou YJ, Zhou JJ, Yang Y, Zhou XB, Wang ZZ, Li SW, Fang LN, Mao XL. Artificial intelligence-assisted endoscopists improve the detection rate of high-risk gastric lesions: A propensity score-matched retrospective study. World J Gastroenterol 2026; 32(21): 117299

"it is better to investigate the role of other factors as diabetes; hypertension; body mass index ; fatty liver disease in gall stone ..." [Read more]

"it is better to investigate the role of other factors as diabetes; hypertension; body mass index ; fatty liver disease in gall stone complications. dietary habits have a significant impact on pathogenesis of gall stone complications. so that a questionnaire of diet intake should be done to investigate the effect of different food staff on symptoms and complications of gall stone disease. " [Collapse]

"How far the research is from the precise mechanism of Yang 1-associated protein 1 in gastric adenocarcinoma? Dina Johar* Department ..." [Read more]

"How far the research is from the precise mechanism of Yang 1-associated protein 1 in gastric adenocarcinoma? Dina Johar* Department of Biochemistry and Nutrition, Faculty of Women for Arts, Sciences and Education, Heliopolis, Cairo, Egypt *Dina Johar, PhD Department of Biochemistry and Nutrition Faculty of Women for Arts, Sciences, and Education Ain Shams University, Cairo, Egypt Phone:+2 01060782045 Email: dinajohar@gu.edu.eg • To whom correspondence should be addressed Abstract The Yang 1-associated protein 1 (YY1AP1) is frequently overexpressed or activated in gastric cancer and is linked to more aggressive disease, poorer prognosis, and metastasis. Although YY1AP1 signaling contributes to pathways that promote proliferation, epithelial–mesenchymal transition, stemness, and drug resistance, the precise mechanism of YY1AP1 in gastric cancer has not been precisely defined. In this commentary, we focus on recent findings on the functional mechanisms of YY1AP1 in gastric adenocarcinoma. The commentary is a significant step forward in understanding the nuanced approach to managing mortality rate in gastric cancer patients, offering valuable insights for clinical decision-making. Keywords: Yang 1-associated protein 1, Gastric adenocarcinoma, Prognosis, Mortality. Core tip YY1AP1 is best understood as both a prognostic biomarker and a functional oncogenic driver in gastric cancer, with evidence pointing to its role in tumor growth, invasion, metastasis, stemness, and treatment resistance. Background YY1AP1 overexpression has been associated with progression, lymph node metastasis, and poor prognosis in gastric carcinoma [1]. Studies found that YY1AP1 activation or high expression predicts worse survival and, in some cohorts, chemoresistance to adjuvant therapy [2-4]. In peritoneal metastatic gastric adenocarcinoma, YY1AP1-high tumor cells showed stem-cell-like properties and were clinically relevant as metastatic drivers [5]. YY1AP1 appears to drive gastric cancer biology through canonical Hippo pathway dysregulation and downstream transcriptional programs that support growth and invasion [6, 7]. Mechanistic studies show YY1AP1 can enhance proliferation, migration, invasion, EMT, and metastasis through signaling changes involving ERK, β-catenin, E-cadherin, vimentin, and lncRNA networks (Sun et al., 2016). Several upstream regulators and interacting partners contribute to YY1AP1 activation in gastric cancer, including H. pylori CagA, NUSAP1, SLC35B4, and CPNE3[7-11]. In gastric adenocarcinoma metastasis, YY1AP1 also linked with altered fatty-acid oxidation and cancer stem cell phenotypes [12]. The recent study of Gu et al. (2026)[13] investigates the clinical significance and functional mechanisms of YY1AP1 in gastric adenocarcinoma, finding its upregulation correlates with poor prognosis and aggressive tumor behavior. It critically assesss the argumentation within the article, focusing on the clarity of the research gap, the strength of the contribution claims, the justification of methods, the alignment of results with the discussion, and the thoroughness of the stated limitations. It also clearly articulates its perceived novelty regarding YY1AP1's role as an independent prognostic factor in gastric adenocarcinoma and its comprehensive investigation. Particularly, YY1AP1’s expression patterns, clinical relevance, biological functions, i.e. in proliferation, migration, gene modulation, and its status as an independent prognostic factor of gastric cancer. The stated aims are highly testable, as evidenced by the detailed methods employed, i.e. immunohistochemistry, RT-qPCR, survival analysis, or in vitro experiments. The authors’ argumentation generally establishes a clear research gap and strong contribution claims, supported by a combination of clinical, in vitro, and bioinformatic data. However, as compared to the aforementioned extensive literature on the specific mechanism/signaling of YY1AP1 in gastric cancer, there are opportunities to enhance methodological justification, ensure stricter alignment between results and discussion, and deepen the analysis of limitations. The Gu et al.[13] study provides sufficient detail for most experimental procedures and statistical analyses. However, specific justifications for certain choices, such as the selection of the MKN45 cell line or the specific online datasets, could be strengthened to enhance the methodological rigor and transparency. For example, “MKN45 is a well-characterized...mechanisms of gastric cancer." This provides a good, albeit brief, justification for using the MKN45 cell line, linking its characteristics to the study's aims. To further strengthen, it worth it to mention if this cell line accurately represents specific subtypes of gastric cancer relevant to the study. Another example, "A semi-quantitative scoring system...combined assessment." The description of the Immunohistochemistry as a scoring system is somewhat vague, lacking specific criteria for how "combined assessment" was performed or how the cutoff for high/low expression was determined. Providing a more precise description of the scoring system and the methodology for categorizing samples is so important. A third example, "The normality of data distribution...Shapiro-Wilk test." While stating the use of the Shapiro-Wilk test, the consequences of non-normal distribution (i.e., use of non-parametric tests) are not explicitly mentioned for cellular assays, which could impact the choice of t-test/ANOVA. It is important to clarify how non-normal data was handled, or confirm that all cellular assay data met normality assumptions for parametric tests. Further, "To further validate and extend...and GSE62254." The choice of these specific online datasets is not justified. It is unclear why these particular datasets were selected and if they represent a diverse or comprehensive set of gastric cancer patient cohorts. Elaborating on the criteria used for selecting these online datasets (i.e., sample size, type of data available, clinical annotation, specific gastric cancer subtypes if applicable) helps the reader. While many of the study claims are correlational, the in vitro experiments aim to establish more direct functional roles. Distinction between correlation and causation more precisely, especially when discussing clinical observations versus experimental manipulations is key. For example, "YY1AP1 significantly influences the pathogenesis... by modulating key cancer-related pathways." This statement implies a direct causal influence, which is partially supported by in vitro modulation of p21, c-myc, and snail, but the broader "pathogenesis" is complex and likely involves multiple factors. While in vitro data supports modulation of some pathways, the term "significantly influences the pathogenesis" might be too strong for the overall conclusion without more comprehensive mechanistic studies. Another example, "Our multivariate analysis identified high YY1AP1 expression... a novel finding in gastric adenocarcinoma." While multivariate analysis identifies independent prognostic factors, the wording implies a direct causal "role" in progression, which is an inference from prognostic value. It worth clarifying that high YY1AP1 expression is associated with poor outcomes and serves as an independent prognostic factor, rather than implying it causes the poor outcome in the context of clinical correlation. The in vitro data strengthens the causal link for proliferation/invasion, but this specific statement is about clinical correlation. The study acknowledges several important limitations, particularly regarding its retrospective design and generalizability, and points to the need for causal relationship studies. However, some limitations, such as the sample size for fresh tissue analysis or the lack of mechanistic studies beyond gene expression changes, could be elaborated or more explicitly stated. I.e., "The retrospective design and the specific patient cohort limit the generalizability of the results." The limitation is stated, but the extent of this limitation on the current conclusions is not fully elaborated. Discussing how this limitation might affect the confidence in YY1AP1 as a prognostic biomarker until prospective validation is inevitable. Accordingly, this suggests while promising, that the prognostic value of YY1AP1 requires validation in larger, prospective, and multi-center cohorts before clinical application. Also, while acknowledged, “The exact molecular mechanisms through which YY1AP1 affects tumor biology... require further elucidation." The discussion could briefly connect this to how the current findings should be interpreted, i.e., as strong associations and initial functional insights, but not definitive mechanistic pathways yet. Therefore, their study provides strong correlational and initial functional evidence, but the precise molecular cascade remains to be fully mapped. This points out the need for more in-depth mechanistic studies (e.g., rescue experiments) to establish direct causality, which is a significant limitation for a study proposing functional roles. Further, "A total of 118 paraffin-embedded and 29 fresh gastric adenocarcinoma samples were analyzed." and "Fresh gastric adenocarcinoma and adjacent nontumor tissues were snap-frozen..." Clearly, the number of fresh samples (29) for RT-qPCR is relatively small compared to the FFPE samples (118) for immunohistochemistry. This smaller sample size for mRNA analysis could be a limitation, especially if there were discrepancies or if it impacts the robustness of mRNA findings. This is not explicitly discussed in the limitations. Adding the smaller sample size for fresh tissue analysis (RT-qPCR) as a limitation, acknowledging its potential impact on the generalizability or statistical power of mRNA-level findings. Declarations Funding This commentary did not receive any speciﬁc grant from funding agencies in the public, commercial, or not-for-proﬁt sectors. The author declare that no honorarium, grant, or other form of payment was given to anyone to produce the manuscript. Conflict of interest The author declares no conflict of interest exists. Consent to publish Not applicable. Availability of data and materials All data generated or analyzed during this study are included in this published article. Acknowledgment N/A References [1] Hu X, Xin Y, Xiao Y, Zhao J. Overexpression of YAP1 is correlated with progression, metastasis and poor prognosis in patients with gastric carcinoma. Pathol Oncol Res. 2014;20:805-11. [2] Yu D, Chen Y, Luo M, Peng Y, S. Y. Upregulated Solute Carrier SLC39A1 Promotes Gastric Cancer Proliferation and Indicates Unfavorable Prognosis. Genet Res (Camb) 2022. [3] Geng ZH, Du JX, Chen YD, Fu PY, Zhou PH, Qin WZ, et al. YY1: a key regulator inhibits gastric cancer ferroptosis and mediating apatinib-resistance. Cancer Cell Int. 2024;12:71. [4] Lee KW, Lee SS, Hwang JE, Jang HJ, Lee HS, Oh SC, et al. [5] Ajani JA, Xu Y, Huo L, Wang R, Li Y, Wang Y, et al. YAP1 mediates gastric adenocarcinoma peritoneal metastases that are attenuated by YAP1 inhibition. Gut. 2021;70:55-66. [6] Messina B, Lo Sardo F, Scalera S, Memeo L, Colarossi C, Mare M, et al. Hippo pathway dysregulation in gastric cancer: from Helicobacter pylori infection to tumor promotion and progression. Cell Death Dis. 2023;14:21. [7] Guo H, Zou J, Zhou L, Zhong M, He Y, Huang S, et al. NUSAP1 Promotes Gastric Cancer Tumorigenesis and Progression by Stabilizing the YAP1 Protein. Front Oncol 2021. [8] Liu Z, Huang S, Cao Y, Yao Y, Li J, Chen J. YAP1 inhibits circRNA-000425 expression and thus promotes oncogenic activities of miR-17 and miR-106. Biochem Biophys Res Commun 2018;4:2370–75. [9] Liu H, Qiu Y, Pei X. Endothelial specific YY1 deletion restricts tumor angiogenesis and tumor growth. Sci Rep. 2020; 10. [10] Liu J ZX, Wang K, Zhang X, Yu Y, Lv Y, Zhang S, Zhang L, Guo Y, Li Y, Yang A, Zhang R, Li J. A novel YAP1/SLC35B4 regulatory axis contributes to proliferation and progression of gastric carcinoma. Cell Death Dis. 2019 Jun 7;10(6):452. doi: 10.1038/s41419-019-1674-2. PMID: 31175271; PMCID: PMC6555804. [11] Li X, Zhong, H., Shi, Q. et al. YAP1-CPNE3 positive feedback pathway promotes gastric cancer cell progression. Cell. Mol. Life Sci. 81, 143 (2024). https://doi.org/10.1007/s00018-024-05178-3. [12] Wang W YY, Zhang RH, Deng JY, Sun Z, Seeruttun SR, Wang ZN, Xu HM, Liang H, Zhou ZW. Standardizing the classification of gastric cancer patients with limited and adequate number of retrieved lymph nodes: an externally validated approach using real-world data. Mil Med Res 2022; 9: 15 [RCA] [PMID: 35387671 DOI: 10.1186/s40779-022-00375-2] [FullText] [Full Text(PDF)]. [13] Gu YC, Li X, Zhao YJ, Wu T, Zhou CG, Hu WL, et al. Yin Yang 1-associated protein 1: Clinical significance and underlying functional mechanisms in gastric cancer. World J Gastroenterol 2026;32:URL: https://www.wjgnet.com/1007-9327/full/v32/i21/116527.htm DOI: https://dx.doi.org/10.3748/wjg.v32.i21. " [Collapse]

Gu YC, Li X, Zhao YJ, Wu T, Zhou CG, Hu WL, Fu ZW, Huang JH, Ren ZY. Yin Yang 1-associated protein 1: Clinical significance and underlying functional mechanisms in gastric cancer. World J Gastroenterol 2026; 32(21): 116527

"This is a well-designed study on biomarkers for early detection of pancreatic cancer with clear clinical value. It addresses key ..." [Read more]

"This is a well-designed study on biomarkers for early detection of pancreatic cancer with clear clinical value. It addresses key clinical challenges and is highly readable and practical. Its major highlight lies in being the first large-scale research to verify that serum S100A6 serves as an effective complement to CA19-9. It performs well in differentiating early pancreatic cancer from chronic pancreatitis and compensating for false-negative results of CA19-9. The combined three-biomarker panel markedly improves diagnostic efficiency, offering valuable guidance for early diagnosis, timely treatment and higher surgical resection rates. The study also objectively acknowledges its limitations including single-center design, absence of external validation and missing Lewis antigen typing, presenting rigorous and prudent conclusions. Overall, this is a clinically oriented and solid translational study. It proposes a new panel strategy for serological screening of pancreatic cancer, and merits further multi-center validation and clinical application. " [Collapse]

Bae GE, Kim SM, Lee JK, Lee SY. First large-scale prospective evaluation of serum S100A6 as a complementary biomarker for early pancreatic cancer detection. World J Gastroenterol 2026; 32(21): 116581

"This study focused on the problem of postoperative recurrence of hepatocellular carcinoma and detected four liver cancer stem cell ..." [Read more]

"This study focused on the problem of postoperative recurrence of hepatocellular carcinoma and detected four liver cancer stem cell markers. It features a rigorous design and reliable data. The results confirmed that CK19 and CD133 are key indicators for evaluating patient prognosis. Combined detection of these markers can substantially improve the predictive efficacy of conventional assessment models, offering practical references for postoperative risk stratification, individualized follow-up and treatment of hepatocellular carcinoma. However, this is a single-center retrospective study with a relatively short follow-up period, so its conclusions need to be further validated by multi-center and long-term researches. " [Collapse]

Jia XQ, Han S, Shang YS, Kong FG, Qi L, Wang CL, Xiong WJ. Expression of liver cancer stem cell markers and association with recurrence and survival in hepatocellular carcinoma. World J Stem Cells 2026; 18(5): 119123

"This systematic review by Gadour et al. provides a well-conducted and clinically valuable analysis of serum bile acid (SBA) as a ..." [Read more]

"This systematic review by Gadour et al. provides a well-conducted and clinically valuable analysis of serum bile acid (SBA) as a biomarker in liver transplant recipients. Following PRISMA guidelines and using the QUIPS tool to assess study quality, the authors performed a rigorous quantitative synthesis, clearly demonstrating that elevated SBA is significantly associated with increased risks of early graft dysfunction, acute rejection, biliary complications, and poor long-term survival. These findings are highly meaningful for clinical practice, as the study confirms that SBA outperforms conventional liver function tests in the early prediction of adverse post-transplant events, with the potential to refine surveillance strategies and enable timely intervention. The manuscript is well-structured, with clear presentation of results, appropriate use of biostatistics, and a balanced discussion of strengths and limitations. While the study represents an important contribution to the field, some key points deserve consideration. Significant heterogeneity across included studies in SBA assay methods, detection time points, and cut-off values limits direct clinical standardization. Additionally, most analyses focused only on total SBA, and the prognostic roles of individual bile acid subtypes remain underexplored. Future large-scale, multicenter prospective studies are needed to address these gaps and validate the clinical utility of SBA monitoring. " [Collapse]

Gadour E, Kuriry H, Miutescu B, Raheem B, Gardezi SA, AlQahtani MS. Diagnostic and prognostic utility of serum bile acid in liver transplant recipients: A systematic review and quantitative synthesis. World J Hepatol 2026; 18(5): 119408

"This study has presented a relationship between MASLD and adjustment of insulin resistance as well as inflammatory factors in patients ..." [Read more]

"This study has presented a relationship between MASLD and adjustment of insulin resistance as well as inflammatory factors in patients using reduced odds ratio which can display the critical role of sleep management. There is a phenomenon hardly to understand where the improper cases is excluded in specific step with corresponding numbers in the flowchart of figure 1. " [Collapse]

Yu QT, Lin YY, Gui ZH, Duan HL, Yang JJ, Meng Y, Peng XT, Liu L, Wan H, Shen J. Mediating roles of insulin resistance and inflammatory markers between healthy sleep scores and metabolic dysfunction-associated steatotic liver disease. World J Gastroenterol 2026; 32(21): 118057

"This multicenter study provides valuable real-world data on eosinophilic gastroenteritis (EGE) in 73 Korean patients. Strengths ..." [Read more]

"This multicenter study provides valuable real-world data on eosinophilic gastroenteritis (EGE) in 73 Korean patients. Strengths include detailed site-specific treatment analysis, showing high response rates to PPI monotherapy in gastroduodenitis (88.9%), and identifying colonic involvement as a key relapse predictor (43.3%). These findings offer practical clinical guidance. A minor suggestion: adopting the updated 2022 international consensus nomenclature (e.g., non-EoE EGIDs, EoG, EoN, EoC) would further enhance cross-study communication. Overall, a clinically useful study with robust regional data. " [Collapse]

Lee J, Kim SE, Cha RR, Lee BE, Choi CW, Jee SR. Presentation and treatment of eosinophilic gastroenteritis in Busan and Gyeongnam, Korea: A multicenter study. World J Gastroenterol 2026; 32(19): 117166

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