Baishideng Publishing Group

Lu DX, Wang ZX, Liu XM, Wu H, Ji LJ, Yan J. Wumei Pills enhance intestinal stem cell - mediated repair in chemotherapy-induced mucositis via Lactobacillus reuteri - dependent modulation of the gut microbiota. World J Stem Cells 2025; 17(9): 107025

"I am thoroughly satisfied with the entire process from submission to acceptance and final publication. WJSC is a remarkable journal, ..." [Read more]

"I am thoroughly satisfied with the entire process from submission to acceptance and final publication. WJSC is a remarkable journal, and I would not hesitate to submit my future work here again. My sincere gratitude to the editor and all the peer reviewers for their valuable time and insightful comments. " [Collapse]

Lv H, Zheng CF, Chen XY, Wei JH, Tao YZ, Feng L, Feng Z, Lu SJ. Sclerostin-silenced human umbilical cord mesenchymal stem cells ameliorate bone metabolism in steroid-induced femoral head necrosis. World J Stem Cells 2025; 17(10): 110190

"It was a rewarding submission experience. World Journal of Gastrointestinal Surgery is very formal and efficient. I can get timely ..." [Read more]

"It was a rewarding submission experience. World Journal of Gastrointestinal Surgery is very formal and efficient. I can get timely answers to my questions, and the whole submission process is very smooth and efficient. Thank you very much for your comments and suggestions, so that the article has been further improved. Thank you very much. " [Collapse]

Zhou QY, Zheng ZH, Lv XL, Guo JQ, Zhang K, Xu HT. Advancement in the diagnosis and treatment of hepatic portal venous gas. World J Gastrointest Surg 2025; 17(10): 109062

"We sincerely thank the editors and reviewers for their valuable feedback and constructive suggestions, which have greatly improved ..." [Read more]

"We sincerely thank the editors and reviewers for their valuable feedback and constructive suggestions, which have greatly improved the quality of our manuscript. All comments have been carefully addressed, and necessary revisions were incorporated into the text, figures, and references. We believe the revised version better reflects the scientific rigor and clarity expected for publication. " [Collapse]

Mahajan AA, Rajendran RL, Gangadaran P, Ahn BC. Engineering ligament tissues: Synergistic power of aligned nanofibers and cyclic stretch. World J Stem Cells 2025; 17(10): 112397

"Over the years, the World Journal has streamlined its process and expanded its horizon with quality publications. The author's site ..." [Read more]

"Over the years, the World Journal has streamlined its process and expanded its horizon with quality publications. The author's site is updated and informative, and one can monitor the progress of the manuscript as it proceeds via the review and publication process. The staff are helpful, and the turnaround time for the staff is excellent. The reviewers are very well versed and there to help improve the quality of your manuscript. " [Collapse]

Parsi S, Shirsat PD, Mahali LP, Surani S, Kashyap R. Sodium-glucose cotransporter 2 inhibitor in heart failure patients and their outcomes: A meta-analysis of randomized controlled trials. World J Cardiol 2025; 17(10): 109731

"Thank you for high standard peer review and editorial processes. Blinded review process and other editorial processes like improving ..." [Read more]

"Thank you for high standard peer review and editorial processes. Blinded review process and other editorial processes like improving language and structure of the article. I advise authors to submit their studies to this publisher having high tech infrasturcture and user friendly interface. This journal will reach to a better place by means of indexing in mean time I think. Thank you. Best regards. " [Collapse]

Sağsöz ME. Comprehensive study comparing different machine learning methods in computed tomography imaging. Artif Intell Med Imaging 2025; 6(1): 101264

"I do believe that the review process made improvements in the manuscript. We could delivery our message with more clarity. The ..." [Read more]

"I do believe that the review process made improvements in the manuscript. We could delivery our message with more clarity. The reviewers made good contribution to improve the quality of manuscript even adding references and different perspective to our discussion. We appreciated it. Also we have received great support from the editorial board. Thank you all for your outstanding support. " [Collapse]

de Camargo AV, de Mattos MD, Kawasaki MK, Gomes DNS, Borges ABB, Vazquez VL, Araujo RLC. Treatment of patients with multiple brain metastases by isolated radiosurgery: Toxicity and survival. World J Clin Oncol 2023; 14(10): 400-408

"Thank you sincerely for the thorough review and valuable feedback. Your insights help us improve and ensure the highest quality. We ..." [Read more]

"Thank you sincerely for the thorough review and valuable feedback. Your insights help us improve and ensure the highest quality. We appreciate the time and effort you dedicated to evaluating our work, and we're grateful for your constructive suggestions. Your support and expertise are truly appreciated as we strive to enhance our project. " [Collapse]

Teixeira MF, Borad M, Serrano Uson Junior PL. Circulating tumor DNA in biliary tract cancers: A review of current applications. World J Clin Oncol 2025; 16(10): 107875

"Thank you for the unique chance to publish our work in this prestigious journal. We would also like to thank the entire staff and ..." [Read more]

"Thank you for the unique chance to publish our work in this prestigious journal. We would also like to thank the entire staff and the reviewers taking timpe in order to provide the useful suggestions and constructive advice that made a significant improvement to the manuscript. We are looking forward to further collaborations. " [Collapse]

Minea H, Singeap AM, Minea M, Chiriac S, Stanciu C, Trifan A. Artificial intelligence in inflammatory bowel disease: Current applications and future directions. World J Gastroenterol 2025; 31(39): 111353

"Excellent experience with the World Journal of Clinical Oncology (WJCO). The publication process was remarkably fast, efficient, and ..." [Read more]

"Excellent experience with the World Journal of Clinical Oncology (WJCO). The publication process was remarkably fast, efficient, and transparent, with a thorough yet agile peer-review system. The submission platform is intuitive and user-friendly, and communication with the editorial team was clear and professional throughout. A truly smooth and positive experience for authors. " [Collapse]

González-Montero J, Valenzuela G, Rojas CI, Burotto M. Sidedness matters: Colon cancer outcomes in low-resource settings. World J Clin Oncol 2025; 16(10): 108937

"We are very satisfied with the overall process of manuscript review and editing, however, the publishing cost of your journal is too ..." [Read more]

"We are very satisfied with the overall process of manuscript review and editing, however, the publishing cost of your journal is too expensive. Many scholars may be hesitant to submit to your journal due to the high publication fees. If the publishing cost can be reduced, it would be a good thing for us scholars. I suggest that your journal reduce its publication costs appropriately, so that more scholars can submit articles to your journal. " [Collapse]

Qiu J, Wu JZ, Gu ZG, Qian JW, Shen T. Influencing factors and predictive model of the early postoperative recurrence of colorectal cancer with obstruction. World J Gastrointest Surg 2025; 17(10): 110695

"Many thanks for the opportunity to publish in a prestigious journal in the field of stem cell-based therapy and Regenerative Medicine. ..." [Read more]

"Many thanks for the opportunity to publish in a prestigious journal in the field of stem cell-based therapy and Regenerative Medicine. It is an honor for us to have our publication. The whole process, encompassing the submission of the manuscript for review, review, editing, and online publication, has been very professional. My group would be happy to contribute to WJSC in the future. " [Collapse]

Safwan M, Bourgleh MS, Al-Ruqi A, Shrebaty O, Almujaydil F, AlOthaim B, AlRashidi N, Haider KH. Living bio-drug therapies using mesenchymal stem cells and exosomes for mechanically ventilated patients with acute respiratory distress syndrome: A systematic review and meta-analysis. World J Stem Cells 2025; 17(10): 111978

"We are deeply grateful to the editors who handled our manuscript. We also thank the reviewers for their careful consideration. Their ..." [Read more]

"We are deeply grateful to the editors who handled our manuscript. We also thank the reviewers for their careful consideration. Their comments greatly helped improve the quality of this manuscript. The editors were prompt and fair in their process. I am very satisfied with this journal and plan to continue submitting our manuscripts to it in the future. Thank you again. Greetings, " [Collapse]

Byeon H. Structural brain correlates of neuropsychomotor performance in older adults with early cognitive decline. World J Psychiatry 2025; 15(10): 109273

"We are deeply grateful to the editors who handled our manuscript. We also thank the reviewers for their careful consideration. Their ..." [Read more]

Akpoveta ED, Okpete UE, Byeon H. Unraveling the gut-liver axis in autoimmune liver disease overlap syndrome: A multi-omics perspective. World J Gastroenterol 2025; 31(37): 112298

"Thank you for the efficient publication process and the professional guidance provided during the review and editing stages. I truly ..." [Read more]

"Thank you for the efficient publication process and the professional guidance provided during the review and editing stages. I truly appreciate the journal’s commitment to maintaining high academic standards and ensuring a smooth experience for authors. I am very satisfied with the overall process and look forward to future opportunities to publish more research in this journal. " [Collapse]

Latsios G, Ktenopoulos N, Koliastasis L, Apostolos A, Kachrimanidis I, Mantzouranis E, Tolis E, Mantziaris V, Skalidis I, Tsalamandris S, Drakopoulou M, Synetos A, Aggeli C, Tsioufis C, Toutouzas K. Role of catheter-based interventions in treating pulmonary embolism. World J Cardiol 2025; 17(10): 111598

"We are deeply grateful to the World Journal of Clinical Oncology for their invaluable support in refining our manuscript from its ..." [Read more]

"We are deeply grateful to the World Journal of Clinical Oncology for their invaluable support in refining our manuscript from its initial submitted draft to the final accepted version. The insightful and constructive comments provided by the esteemed reviewers, together with the professional editorial assistance and meticulous oversight from the Chief Editor and the Editorial Board, substantially enhanced the scientific rigor and overall presentation of our work. We sincerely appreciate their time, expertise, efforts and commitment throughout the peer-review and publication process. We are truly honored to have our manuscript published in the World Journal of Clinical Oncology. " [Collapse]

Rather RA. Oncogenic B-Raf proto-oncogene, serine/threonine kinase-mediated hedgehog signalling in the pathogenesis and targeted therapy of melanoma. World J Clin Oncol 2025; 16(10): 105117

"I encountered some difficulties in adding the references and uploading the supporting documents in the portal, which could be ..." [Read more]

"I encountered some difficulties in adding the references and uploading the supporting documents in the portal, which could be simplified. While the peer review process was very quick, the post-review period for the second decision and the time from acceptance to publication were relatively long. The production editors provided excellent proofreading and support. " [Collapse]

Sekhar A, Kandasamy M. Heart-brain axis, gliotransmitters and peripheral neurogenesis: Emerging regenerative roles of cardiac nexus glia in health and disease. World J Cardiol 2025; 17(10): 109174

"I would like to express my gratitude to all the teachers in the editorial department for their support and assistance. Your journal ..." [Read more]

"I would like to express my gratitude to all the teachers in the editorial department for their support and assistance. Your journal has a fast review process and the review comments are very fair and helpful in improving the quality of the manuscripts. If there are any more manuscripts, I plan to continue submitting them to your publication. " [Collapse]

Pan J, Zhang RS, Chen Y, Cao XH, Yang ZH, Lu L, Chen YT, Chu XY. Long-term survival after multimodality treatment of metastatic mixed adenoneuroendocrine carcinoma of colon: A case report. World J Gastrointest Surg 2025; 17(10): 111975

"We would like to express our gratitude to the assistant editor, scientific editor, peer reviewers, editorial office director, journal ..." [Read more]

"We would like to express our gratitude to the assistant editor, scientific editor, peer reviewers, editorial office director, journal editor-in-chief, company editor-in-chief, language editor, production editor, and the entire World Journal of Gastrointestinal Surgery team for their dedicated efforts throughout the publication process of our manuscript. The World Journal of Gastrointestinal Surgery is beautifully produced, featuring clear images and visually appealing pages. My colleagues and I are deeply honored to have our work published in this esteemed journal. The journal operates with remarkable speed in its review of manuscripts, maintaining an open and transparent peer review process that delivers highly professional and thorough evaluations. The entire editorial team demonstrates exceptional diligence, a consistently friendly attitude, and outstanding expertise. We look forward to submitting further work to the World Journal of Gastrointestinal Surgery. " [Collapse]

He YF, He QT. Single-port laparoscopic hernia needle therapy: New hope for the treatment of inguinal hernia in children. World J Gastrointest Surg 2025; 17(10): 106800

"Dear Editor I would like to express my sincere gratitude to you and the editorial team of the World Journal of Gastrointestinal Surgery ..." [Read more]

"Dear Editor I would like to express my sincere gratitude to you and the editorial team of the World Journal of Gastrointestinal Surgery for publishing my article, I deeply appreciate the time, effort, and constructive feedback provided during the peer review and editing process.It is an honor to have my work featured in such a respected journal, and I am grateful for the opportunity to contribute to the field. Please extend my thanks to the reviewers and the entire publication team for their professionalism and support throughout the process. Thank you once again for your valuable guidance and assistance. With warm regards Dr Ankit Shukla " [Collapse]

Shukla A, Kalayarasan R, Gochhait D, Harichandrakumar KT, Pottakkat B. Assessment of the status of micrometastasis and tumor spillage among the patients undergoing thoracoscopic esophagectomy for carcinoma esophagus. World J Gastrointest Surg 2025; 17(10): 107741

19752 items Read more >>

Article Quality Tracking-Peer-Review

"Artificial intelligence has brought about a real revolution in various areas of human activities, including medical science. In recent ..." [Read more]

"Artificial intelligence has brought about a real revolution in various areas of human activities, including medical science. In recent years, AI has also emerged as a method to support the correct diagnosis and treatment of acute pancreatitis. Some elements of AI, such as machine learning, deep learning, natural language processing, and network pharmacology, seem to significantly facilitate diagnostic and therapeutic decisions in the treatment of patients with acute pancreatitis, through the analysis of clinical records, medical images, laboratory values, genomic data, and physiological signals in real time. AI functions as advanced decision support, enhancing clinical judgment with intelligence derived from diagnostic data, assessing risks to the patient from potential complications, and helping safely predict the disease. The authors also discuss future directions for AI development in the treatment of acute pancreatitis. As emphasized by the authors of this review, today's practical medicine often requires an interdisciplinary approach that integrates clinical experience, computational modeling, and ethical design. These largely theoretical data currently have limited application, especially in developing countries worldwide. For all health systems and in any country where AI is applied, its assistance should consist of improving decision-making through hybrid human-artificial intelligence models. The future looks excellent, although it causes concern and fear to the undersigned." [Collapse]

Zhang XY, Hu MD, Maimaitijiang D, Wang T, Wang L. Artificial intelligence in pancreatitis: A narrative review on advancing precision diagnosis, prognosis, and therapeutic strategies. World J Gastroenterol 2025; 31(39): 110971

"This review explores the bidirectional regulation between the gut microbiome and the immune system within the colorectal cancer (CRC) ..." [Read more]

"This review explores the bidirectional regulation between the gut microbiome and the immune system within the colorectal cancer (CRC) microenvironment. It highlights how microbial metabolites and immune signaling pathways influence tumor progression, immune evasion, and therapeutic response. Key mechanisms include TLR4 and NLRP3 activation, SCFA modulation, and PD-1 pathway interactions. The authors discuss emerging interventions such as engineered probiotics, FMT, and metabolic vaccines targeting the microbiota-immune axis. Overall, the study provides a comprehensive framework for developing personalized CRC therapies through microbiome modulation." [Collapse]

Liu XX, Yang B, Tang DX. Bidirectional regulation of the gut microbiome-immune axis in the immune microenvironment of colorectal cancer and targeted interventions. World J Gastrointest Oncol 2025; 17(10): 109503

"This retrospective two-center study investigates ultrasound features of primary intestinal lymphoma in children and their correlation ..." [Read more]

"This retrospective two-center study investigates ultrasound features of primary intestinal lymphoma in children and their correlation with prognosis. Twenty-eight pediatric cases were classified into focal segmental and extensive types based on sonographic findings. Extensive-type lymphoma was associated with significantly elevated LDH levels and poorer outcomes compared to the segmental type. Ultrasound classification and LDH levels showed strong prognostic relevance, while pathological type, age, and treatment modality did not. The study concludes that ultrasound is a valuable tool for diagnosis, classification, and prognosis prediction in pediatric intestinal lymphoma." [Collapse]

Huang SF, Yang F, Chen WJ, Zhang XH. Ultrasound features of primary intestinal lymphoma in children and their correlation with prognosis: A two-center experiment. World J Gastrointest Oncol 2025; 17(10): 109450

"This review highlights how lipid metabolic reprogramming drives colorectal cancer (CRC) progression, immune evasion, and therapy ..." [Read more]

"This review highlights how lipid metabolic reprogramming drives colorectal cancer (CRC) progression, immune evasion, and therapy resistance. It discusses key alterations in fatty acid synthesis, oxidation, and cholesterol metabolism, as well as the impact of high-fat diets and gut microbiota on the tumor microenvironment. The authors emphasize the role of lipid metabolism in shaping immunosuppressive dynamics and promoting cancer stemness and metastasis. By identifying actionable lipid-related pathways and enzymes, the review proposes novel therapeutic strategies, including combinations with immunotherapy. Overall, it offers a comprehensive and timely framework for advancing precision oncology in CRC." [Collapse]

Wang CD, Zhang BX, Song J. Lipid metabolic reprogramming in colorectal cancer: Insights to mechanisms and therapeutics. World J Gastrointest Oncol 2025; 17(10): 109398

"This multicenter retrospective study analyzed 189 colorectal cancer (CRC) patients admitted to intensive care units (ICUs) across ..." [Read more]

"This multicenter retrospective study analyzed 189 colorectal cancer (CRC) patients admitted to intensive care units (ICUs) across 37 cancer-specialized hospitals in China. The 90-day mortality rate was relatively low at 12.2%, with elective surgery and conventional oxygen therapy associated with better outcomes. Chemotherapy history and unplanned ICU transfers were linked to higher mortality, while severity scores like SOFA and APACHE II showed only moderate predictive value. This study is commendable for its large-scale, multicenter design and its focus on a clinically important yet underexplored patient population. By identifying key prognostic factors and highlighting the limitations of current scoring systems, the authors provide valuable insights that can inform ICU admission decisions and personalized care strategies for CRC patients." [Collapse]

Dong Q, Xia R, Xing XZ, Wang CS, Ma G, Wang HZ, Zhu B, Zhao JH, Zhou DM, Zhang L, Huang MG, Quan RX, Ye Y, Zhang GX, Jiang ZY, Huang B, Xu SL, Xiao Y, Zhang LL, Lin RY, Ma SL, Qiu YA, Zheng Z, Sun N, Xian LW, Li J, Zhang M, Guo ZJ, Tao Y, Zhou XZ, Chen W, Wang DX, Chi JY, Wang DH, Liu KZ. Intensive care unit outcomes and prognostic factors of colorectal cancer. World J Gastrointest Oncol 2025; 17(10): 108539

"This review highlights the link between ulcerative colitis (UC) and colitis-associated colorectal cancer (caCRC), emphasizing how ..." [Read more]

"This review highlights the link between ulcerative colitis (UC) and colitis-associated colorectal cancer (caCRC), emphasizing how chronic inflammation drives cancer development. It outlines key molecular pathways, immune responses, and microbiota changes involved in this process, and discusses current strategies for surveillance, chemoprevention, and surgical management. The authors advocate for precision medicine approaches to improve early detection and personalized care. The manuscript is commendable for its comprehensive integration of molecular and clinical insights. By combining updated surveillance guidelines with emerging biomarker research, it offers a forward-thinking framework that can guide more effective prevention and treatment strategies for caCRC in UC patients." [Collapse]

Catalano M, Mini E, Nobili S, Vascotto IA, Ravizza D, Amorosi A, Tonelli F, Roviello F, Roviello G, Nesi G. Ulcerative colitis and colorectal cancer: Pathogenic insights and precision strategies for prevention and treatment. World J Gastrointest Oncol 2025; 17(10): 108514

"1 Ethics: Not applicable 2 Methods: Case report that the manuscript was prepared and revised according to the CARE Checklist ..." [Read more]

"1 Ethics: Not applicable 2 Methods: Case report that the manuscript was prepared and revised according to the CARE Checklist (2016). 3 Results: case sharing of case presentation, findings and images. 4 Figures and tables: The author provides perfect images which is good quality and easily understandable plus interesting findings. 5 Biostatistics: Not applicable 6 References: Record the latest references which are important in this field and related to the scientific problems and case addressed in the study. 7 Language: The language in article correctly, clearly and concisely express the information. No grammatical and language mistakes. 8 Caveats or drawbacks: Not detected" [Collapse]

Wang WQ, Yang JP, Dong JW, Chen YB. Misdiagnosis of Crohn’s disease as appendicitis: A case report. World J Gastrointest Surg 2025; 17(9): 108348

"1 Ethics: Not applicable 2 Methods: Case report that the manuscript was prepared and revised according to the CARE Checklist ..." [Read more]

"1 Ethics: Not applicable 2 Methods: Case report that the manuscript was prepared and revised according to the CARE Checklist (2016). 3 Results: case sharing of case presentation, findings and images. 4 Figures and tables: The author provides good images which is good quality and easily understandable. Can be better figures intra-operative 5 Biostatistics: Not applicable 6 References: Record the latest references which are important in this field and related to the scientific problems and case addressed in the study. 7 Language: The language in article correctly, clearly and concisely express the information. No grammatical and language mistakes. 8 Caveats or drawbacks: Not detected" [Collapse]

Zhang J, Sun S, Zheng S, Ma YY, Chen G. Gastric adenomyoma in children: A case report. World J Gastrointest Surg 2025; 17(9): 107297

"1 Ethics: Not applicable 2 Methods: Case report that the manuscript was prepared and revised according to the CARE Checklist ..." [Read more]

"1 Ethics: Not applicable 2 Methods: Case report that the manuscript was prepared and revised according to the CARE Checklist (2016). 3 Results: case sharing of case presentation, findings and images. 4 Figures and tables: The author provides perfect images which is good quality and easily understandable. 5 Biostatistics: Not applicable 6 References: Record the latest references which are important in this field and related to the scientific problems and case addressed in the study. 7 Language: The language in article correctly, clearly and concisely express the information. No grammatical and language mistakes. 8 Caveats or drawbacks: Not detected" [Collapse]

Moon YJ, Lee SH. Inferior mesenteric arteriovenous fistula: Two case reports. World J Gastrointest Surg 2025; 17(9): 107139

"1 Ethics: Not applicable 2 Methods: Case report that the manuscript was prepared and revised according to the CARE Checklist ..." [Read more]

"1 Ethics: Not applicable 2 Methods: Case report that the manuscript was prepared and revised according to the CARE Checklist (2016). 3 Results: case sharing of case presentation, findings and images. 4 Figures and tables: The author provides good images which is good quality and easily understandable. need arrow in intra-operative image 5 Biostatistics: Not applicable 6 References: Record the latest references which are important in this field and related to the scientific problems and case addressed in the study. 7 Language: The language in article correctly, clearly and concisely express the information. No grammatical and language mistakes. 8 Caveats or drawbacks: Not detected" [Collapse]

Ahunayizhi A, Zhang XL, Chen Q, Wang H, Ding G, Akumuo S, Wang XX, Ruan XJ. Laparoscopic management of gallstones in a duplicate gallbladder with double cystic ducts: A case report. World J Gastrointest Surg 2025; 17(9): 110796

"1 Ethics: Not applicable 2 Methods: Case report that the manuscript was prepared and revised according to the CARE Checklist ..." [Read more]

"1 Ethics: Not applicable 2 Methods: Case report that the manuscript was prepared and revised according to the CARE Checklist (2016). 3 Results: case sharing of case presentation, findings and images. 4 Figures and tables: The author provides not medical photograph especially resected specimens photo. 5 Biostatistics: Not applicable 6 References: Record the latest references which are important in this field and related to the scientific problems and case addressed in the study. 7 Language: The language in article correctly, clearly and concisely express the information. No grammatical and language mistakes. 8 Caveats or drawbacks: Not detected" [Collapse]

Guo Q, Lu HY, Lyu H, Tian H, Zhao Q, Zheng YC. Complete appendiceal intussusception and appendiceal mucinous tumor: A case report and review of literature. World J Gastrointest Surg 2025; 17(9): 109320

"This is a very interesting analysis and "observational" association between BMI and ALF. This work supports the knowledge about obesity ..." [Read more]

"This is a very interesting analysis and "observational" association between BMI and ALF. This work supports the knowledge about obesity and the worldwide problem it represents as a health problem. With all due respect, this work lacks further analysis (hypothesis) on how this increased BMI contributes to organ failure. Further analysis should focus not only on organ (liver in this case) failure but on gastrointestinal symptomatology (effects) in general." [Collapse]

Krishnan A, Khan S, Gips J, Alqahtani SA, Vaidya D, Liu YS, Kim A, Su A, Gurakar A, Hamilton JP, Woreta TA. Body mass index and its association with clinical outcomes in acute liver failure. World J Clin Cases 2025; 13(30): 109212

"1 Ethics: Ethical approval is stated as obtained from a relevant committee, meeting requirements. 2 Methods: Experimental methods ..." [Read more]

"1 Ethics: Ethical approval is stated as obtained from a relevant committee, meeting requirements. 2 Methods: Experimental methods (cell culture, molecular/functional assays, microscopy) are standard, well-described, and repeatable via established protocols/citations. 3 Results: Results are authentic (consistent dose-effects, clear molecular data). The hypothesis that Prdx1 inhibits CRC via pyroptosis is partially validated (robust in vitro support, but lacks in vivo/clinical evidence for universal significance). Notably, the loading control (β-actin) appears uneven between N17 and T17 samples, which may raise minor concerns about sample loading consistency. While the study uses three cell lines to validate findings—enhancing data volume and credibility—it would further strengthen translational relevance if the authors validated Prdx1’s effects using patient-derived organoids (PDOs), which better recapitulate in vivo tumor biology. 4 Figures and tables: Figures are well-constructed with clear annotations, and tables present data effectively. However, most images rely heavily on black-and-white visuals, which could be aesthetically enhanced (e.g., using color coding for different groups or molecular targets) to improve readability and visual communication of key results. 5 Biostatistics: Statistical analyses are appropriately applied, with accurate p-values and data visualization (error bars, sample sizes). 6 References: Citations include key recent works on pyroptosis, inflammasomes, and CRC; citations are scientific, relevant, and not overly self-referential. 7 Language: Language is clear, concise, and grammatically correct. 8 Caveats or drawbacks: Animal-level experimental validation is insufficient; currently, only tumor size is assessed. Supplementing with detection of relevant proteins (e.g., NLRP3, GSDMD, caspase-1) or gene expression in tumor tissues from animal models would more be much better. In summary, this study is well-conducted, utilizing paired tumor and adjacent non-tumor tissues from 20 patients, which enhances its clinical relevance. To further extend the current findings, it would be valuable for the authors to employ clinical specimens for establishing patient-derived organoids (PDOs) or patient-derived xenograft (PDX) models in future work, thereby validating the results in an in vivo context. Additionally, given the involvement of immunogenic cell death (ICD) discussed in the study, subsequent research could also explore the efficacy and underlying mechanisms related to tumor immunity. " [Collapse]

He Y, Liu J, Zhou N, Xie LX, Jiang YF, Chen CL. Peroxiredoxin 1 inhibits tumorigenesis by activating the NLRP3/GSDMD pathway to induce pyroptosis of colorectal cancer cells. World J Gastroenterol 2025; 31(36): 111557

"This large-scale, 20-year retrospective study by Huang et al. is a significant achievement, successfully establishing the first ..." [Read more]

"This large-scale, 20-year retrospective study by Huang et al. is a significant achievement, successfully establishing the first genome-wide polygenic risk score (PRS) for diabetic retinopathy (DR) in a Taiwanese Han population. The study's key contribution is demonstrating that a high PRS is strongly associated not just with DR incidence, but more critically, with disease severity requiring interventions like laser treatment or surgery. This suggests the PRS could be a valuable tool for identifying patients needing more intensive monitoring. Despite these strengths, the study highlights a crucial unresolved issue: the clinical utility of the PRS beyond existing risk factors. The central question remaining is whether this genetic information provides actionable predictive power over and above standard clinical data such as HbA1c and diabetes duration. Furthermore, the findings' generalizability to other ethnicities is yet to be determined, as the study was confined to a specific Asian population. Therefore, the essential next step is to conduct prospective validation studies aimed at creating an integrated risk model. Such a model would combine the PRS with established clinical variables to definitively quantify its added value in personalizing DR screening strategies and improving patient outcomes." [Collapse]

Huang YC, Liao WL, Lin HJ, Huang YT, Chang YW, Yang JS, Weng AL, Tsai FJ. Polygenic risk score for predicting diabetic retinopathy in patients with type 2 diabetes: A twenty-year follow-up study. World J Diabetes 2025; 16(10): 110138

"This is a thoughtful and well-executed study that provides a valuable, quantitative analysis of the interplay between type 2 diabetes ..." [Read more]

"This is a thoughtful and well-executed study that provides a valuable, quantitative analysis of the interplay between type 2 diabetes (T2D), dry eye syndrome (DES), and corneal neuropathy. A significant strength of this paper lies in its robust methodology, which combines standardized subjective questionnaires (SPEED) with objective clinical measures (NIBUT, SIt) and advanced imaging through corneal confocal microscopy. Despite these strengths, the study's contributions are constrained by limitations inherent in its design, which the authors commendably acknowledge. The primary issue is the retrospective, single-center nature of the research and the relatively small sample size of the DES group (n=27). This framework, while excellent for identifying strong associations, cannot establish causality. A critical unanswered question remains: does poor glycemic control directly cause corneal neuropathy which then leads to DES, or do these pathologies develop in parallel? The cross-sectional data cannot delineate this temporal sequence. Another unresolved problem is the potential confounding influence of systemic diabetic peripheral neuropathy. The study does not differentiate whether the observed corneal neuropathy is an isolated ocular pathology or a manifestation of a wider systemic nerve degeneration. This distinction is vital, as it carries different implications for both prognosis and treatment. To build upon this solid foundation, the next logical step would be to conduct a large-scale, prospective, multicenter cohort study. Following patients over several years would allow for the establishment of a causal sequence between fluctuations in glycemic control, the onset and progression of corneal nerve damage, and the emergence of clinical DES. Such a study should also incorporate comprehensive neurological examinations to contextualize the corneal findings within the patient's overall systemic neuropathy status. Further investigation into the underlying biological mechanisms, perhaps by analyzing inflammatory biomarkers in the tear film of these patients, could also illuminate the pathway from hyperglycemia to nerve damage, potentially revealing new therapeutic targets beyond blood sugar management." [Collapse]

Han WT, Zhao J, Feng WL, Ma WT. Type 2 diabetes complicated by dry eye syndrome: Analysis of dry eye symptoms, corneal neuropathy, and influencing factors. World J Diabetes 2025; 16(10): 109080

"In the 1970s and 1980s, vagotomy was widely used for duodenal ulcers. However, with the widespread use of PPIs and high rates of ..." [Read more]

"In the 1970s and 1980s, vagotomy was widely used for duodenal ulcers. However, with the widespread use of PPIs and high rates of recurrence, vagotomy soon fell out of favor. However, it has now been reported that patients who have undergone vagotomy have a lower incidence of Parkinson's disease, based on the brain-gut axis. The authors report a high incidence of IBD 10 years after vagotomy. I believe this paper is an excellent theoretical explanation of the relationship between vagotomy and organs such as gut flora." [Collapse]

da Silva ACA, Severo JS, dos Santos BLB, Soares HS, Martins JA, Lima RSP, Gadelha KKL, Torres-Leal FL, Correia-de-Sá P, Magalhães PJC, Santos AA, da Silva MTB. Role of physical exercise, vagal nerve stimulation, and vagotomy in inflammatory bowel disease. World J Gastroenterol 2025; 31(38): 111252

"This retrospective cohort study from Johns Hopkins University provides important evidence linking body mass index (BMI) to adverse ..." [Read more]

"This retrospective cohort study from Johns Hopkins University provides important evidence linking body mass index (BMI) to adverse outcomes in acute liver failure (ALF). Analyzing 196 patients over two decades, the authors found that both overweight and obesity independently doubled the risk of death or liver transplantation. Given the rarity of ALF, this well-characterized cohort and rigorous statistical analysis make the findings clinically meaningful. The study’s strengths include clear case definition using AASLD criteria, comprehensive data collection, and appropriate use of multivariable Cox regression and Kaplan–Meier analysis. The results are consistent with prior evidence from the Acute Liver Failure Study Group, reinforcing obesity as a significant prognostic factor. Importantly, overweight and obese patients showed higher rates of advanced hepatic encephalopathy and renal dysfunction, emphasizing the metabolic and inflammatory burden in this population. However, BMI alone may not accurately represent metabolic health. Future studies incorporating waist circumference, hepatic fat indices, or noninvasive imaging markers could improve risk stratification. Moreover, temporal changes in critical care and transplant practices warrant consideration across the 20-year study period. Overall, this well-designed and clinically valuable study strengthens the link between metabolic dysfunction and ALF outcomes. Incorporating BMI or related measures into existing prognostic models could further refine risk prediction and guide early intervention." [Collapse]

"This article offers an in-depth overview of current adjuvant strategies and their challenges in treating HCC. The authors note that ..." [Read more]

"This article offers an in-depth overview of current adjuvant strategies and their challenges in treating HCC. The authors note that China represents nearly half of global HCC cases. Despite surgical resection, recurrence rates remain high and five-year survival rates low. The article reviews nine adjuvant approaches, but their effectiveness is still uncertain. While the review is concise, it would benefit from clearer organization—such as using subsections for each therapy focusing on efficacy, challenges, and prospects for future research. Including a comparative table summarizing the therapies could also enhance understanding. The review lacks a critical evaluation of the referenced studies. Expanding on emerging therapies, their mechanisms, and potential advantages would strengthen the analysis. Additionally, incorporating data from other regions would offer a more comprehensive perspective on global HCC management. " [Collapse]

Liu F, Zhang J, Li K. Postoperative adjuvant management in hepatocellular carcinoma: A review of therapeutic efficacy and prognostic outcomes. World J Hepatol 2025; 17(9): 107631

" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..." [Read more]

" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied." [Collapse]

Barbosa OA. Small bowel ulcers and bleeding: An overlooked yet critical clinical challenge. World J Clin Cases 2025; 13(30): 109445

" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..." [Read more]

Curto A, Iamello RG, Lynch EN, Galli A. Advancing the management of primary biliary cholangitis: From pathogenesis to emerging therapies. World J Clin Cases 2025; 13(30): 109028

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Peer-Reviewers and Manuscript Statistics

Editorial board members: 2264

Peer-reviewers: 34237

Manuscripts received today: 4

Manuscript reviews today: 9

Unhandled manuscripts today: 163

Active peer-reviewers today: 843

Reviewer acceptance today: 11

Reviewer refusals today: 10

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Total rejected manuscripts: 43421

Total peer-reviewers: 4442493

Total submissions: 36326